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Rapid retinal functional testing 认领 引用
1
作者 Sarah A.Weitzman Vivienne Greenstein +2 位作者 Alauddin Bhuiyan Albert Hofeldt Steven Kane 《Annals of Eye Science》 2021年第3期37-44,共8页
The most prominent causes of loss of vision in individuals over 50 years include age-related macular degeneration(AMD),glaucoma,and diabetic retinopathy(DR).While it is important to screen for these diseases effective... The most prominent causes of loss of vision in individuals over 50 years include age-related macular degeneration(AMD),glaucoma,and diabetic retinopathy(DR).While it is important to screen for these diseases effectively,current eye care is not properly doing so for much of the population,resulting in unfortunate visual disability and high costs for patients.Innovative functional testing can be unified with other screening methods for a more robust and safer screening and prediction of disease.The goal in the creation of functional testing modalities is to develop highly sensitive screening tests that are easy to use,accessible to all users,and inexpensive.The tests herein are deployed on an iPad with easily understood and intuitive instructions for rapid,streamlined,and automatic administration.These testing modalities could become highly sensitive screenings for early detection of potentially blinding diseases.The applications from our collaborators at AMA Optics include a cone photostress recovery test for detection of AMD and diabetic macular edema(DME),brightness balance perception for optic nerve dysfunction and especially glaucoma,color vision testing which is a broad screening tool,and visual acuity test.Machine learning with the combined structural and functional data will optimize identification of disease and prediction of outcomes.Here,we review and assess various tests of visual function that are easily administered on a tablet for screening in primary care.These user-friendly and simple screening tests allow patients to be identified in the early stages of disease for referral to specialists,proper assessment and treatment. 展开更多
关键词 Age-related macular degeneration(AMD) glaucoma diabetic retinopathy screening functional testing photostress recovery dark adaptation brightness balance color vision visual acuity iPad
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Outcomes of anatomical versus functional testing for coronary artery disease 认领 引用
2
《South China Journal of Cardiology》 CAS 2015年第1期59-60,共2页
Background Many patients have symptoms suggestive of coronary artery disease （CAD） and are often eval- uated with the use of diagnostic testing, although there are limited data from randomized trials to guide care.
关键词 CAD CTA Outcomes of anatomical versus functional testing for coronary artery disease
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Radiologic progression with minimal functional decline in cystic fibrosis:Insights from a prospective study 认领 引用
3
作者 Jan Mohd Suhail Mohmed Imran Wagay +3 位作者 Arshed Hussain Parry Irshad Mohiuddin Bhat Riaz Rasool Sheikh Mushtaq Ahmad Bhat 《World Journal of Radiology》 2026年第5期52-59,共8页
BACKGROUND Timely identification and monitoring of lung disease progression are key components of effective management in patients with cystic fibrosis(CF).Pulmonary function tests(PFTs)and high-resolution computed to... BACKGROUND Timely identification and monitoring of lung disease progression are key components of effective management in patients with cystic fibrosis(CF).Pulmonary function tests(PFTs)and high-resolution computed tomography(HRCT)scans are commonly used to assess disease progression in these patients.Determining which modality provides the most sensitive and reliable assessment is crucial for establishing effective disease monitoring guidelines,particularly in India,where national guidelines are lacking.AIM To assess the progression of lung disease in patients with CF using a combination of HRCT and PFTs.METHODS A total of 32 patients with CF were prospectively enrolled from the outpatient clinic and followed longitudinally.Clinical and physiological parameters,including age,spirometric indices,and HRCT based Bhalla scores,were evaluated at baseline and after one-year followup.Paired comparisons between baseline and follow-up HRCT scores,as well as baseline and follow-up PFT parameters,were performed using a two-tailed paired t-test to assess statistically significant changes over the follow-up period.Pearson correlation coefficient(r)was used to evaluate the relationship between HRCT scores and spirometric parameters at each individual time point(baseline and follow-up).A P value0.05).CONCLUSION Despite significant radiological progression of structural lung damage detected by HRCT,pulmonary function parameters remained relatively stable.These findings suggest that PFTs may be less sensitive in detecting progressive structural deterioration in CF,underscoring the value of HRCT as a sensitive tool for disease monitoring and early detection of worsening lung disease. 展开更多
关键词 Cystic fibrosis High-resolution computed tomography chest Pulmonary function test Bhalla scoring system Bronchiectasis
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Modelling and Optimizing Motherboard Functional Testing in Laptop Manufacturing 认领 引用
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作者 BAI Peng KANG Yu +2 位作者 WANG Kangcheng ZHAO Yunbo DONG Shaojie 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2024年第6期2406-2423,共18页
Functional testing is key to fulfill quality control in laptop manufacturing and is of great economic value.However,due to the unavailability of practical data,mathematical model and systematic perspective,it has bare... Functional testing is key to fulfill quality control in laptop manufacturing and is of great economic value.However,due to the unavailability of practical data,mathematical model and systematic perspective,it has barely been touched from the academic community to date.For the first time,this work provides technical understanding of the key principles of functional testing,mathematically models the general framework,elucidates existing testing strategy under the proposed framework and model,and finally proposes a specified optimization strategy which outperforms existing strategies.This work lays the model foundation for the further optimization of functional testing,and can be regarded as a good example of how a systematic approach can solve practical industrial challenges. 展开更多
关键词 Laptop manufacturing modelling motherboard functional testing optimization
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Blow-up results for the weakly coupled system of semilinear wave equations with weak dampings 认领 引用
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作者 MING Sen FAN Xiong-mei +1 位作者 REN Cui XIE Jin 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2026年第1期1-20,共20页
This work is devoted to the study of initial boundary value problem for k-component system of semilinear wave equations with several fundamental boundary conditions(namely,the Dirichlet,Neumann,and Robin boundary cond... This work is devoted to the study of initial boundary value problem for k-component system of semilinear wave equations with several fundamental boundary conditions(namely,the Dirichlet,Neumann,and Robin boundary conditions).Blow-up results and lifespan estimates of solutions to the problem with two different types of weak damping terms and power nonlinearities in the sub-critical and critical cases on exterior domain are obtained.The test function technique is performed in the proofs.It is worth observing that our results in Theorem 1.1 in this article contain the results in[6]as a special case whenθ=0.To the best of our knowledge,the results in Theorems 1.1-1.2 are new. 展开更多
关键词 initial boundary value problem semilinear wave equations weak damping terms lifespan estimates test function technique
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Risk Factors for Postoperative Pulmonary Complications Following Posterior Spinal Fusion in Adolescent Scoliosis:A Retrospective Cohort Study 认领 引用
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作者 Jing Zhan Ai Hu +2 位作者 Huai-Yuan Wang Yue-Lun Zhang Wei-Yun Chen 《Chinese Medical Sciences Journal》 CAS CSCD 2026年第1期1-9,I0001,共9页
Objective Scoliosis is a prevalent spinal deformity that severely impacts the physical and psychological well being of adolescents and often requires surgical correction.This study aimed to investigate the risk factor... Objective Scoliosis is a prevalent spinal deformity that severely impacts the physical and psychological well being of adolescents and often requires surgical correction.This study aimed to investigate the risk factors for postoperative pulmonary complications(PPCs)following posterior spinal fusion in adolescent scoliosis,with a specific focus on evaluating the predictive value of preoperative forced vital capacity(FVC)and etiological classification.Methods This retrospective cohort study enrolled adolescents who underwent posterior spinal fusion for scoliosis correction at Peking Union Medical College Hospital between January 2018 and December 2022.The baseline demographic,clinical,and perioperative variables were collected.The primary endpoint was the occurrence of PPCs prior to hospital discharge.Univariate and multivariable binary logistic regression analyses were conducted to identify independent risk factors.Results A total of 1,234 patients were included,of whom 29(2.35%)developed PPCs and 1,205 did not.Univariate analysis revealed that 12 variables,including non-idiopathic scoliosis,a larger main thoracic curve,a decreased FVC%predicted,and increased perioperative blood transfusions,were significantly associated with PPCs(P<0.05).Multivariable logistic regression model showed that non-idiopathic scoliosis emerged as the sole independent risk factor for PPCs[adjusted odds ratio(OR)=5.478,95%confidence interval:2.017-19.148,P=0.002].Preoperative FVC%predicted(adjusted OR=0.993,P=0.497)and main thoracic curve(adjusted OR=1.002,P=0.736)did not demonstrate independent predictive value.Conclusions Non-idiopathic scoliosis,rather than preoperative pulmonary function or curve severity,is an independent risk factor for PPCs following posterior spinal fusion in adolescents.During perioperative respiratory risk assessment,particular emphasis should be placed on the etiological classification of these patients. 展开更多
关键词 scoliosis adolescent spinal fusion postoperative complications respiratory function tests risk factors
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Predictors of mortality and liver transplant requirement in patients with hepatitis A virus:A case series from Mexico 认领 引用
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作者 Cristian Alejandro Bautista-Mondragón Alejandra Madeleine Mijangos-Trejo +2 位作者 Octavio González-Chon Pablo Mondragón-Ratkovich Norberto Carlos Chávez-Tapia 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期135-142,共8页
BACKGROUND Hepatitis A virus(HAV)infection remains a significant cause of acute viral hepatitis globally,and the endemicity pattern is intermediate in Mexico.Although most cases follow a benign and self-limited course... BACKGROUND Hepatitis A virus(HAV)infection remains a significant cause of acute viral hepatitis globally,and the endemicity pattern is intermediate in Mexico.Although most cases follow a benign and self-limited course,less than 5%of patients with HAV infection progress to acute liver failure,which carries mortality rates of 13%-33%depending on access to liver transplantation(LT).The identification of clinical and biochemical predictors of adverse outcomes is crucial to improve early risk stratification,optimize patient management,and guide timely referral to transplant centers.AIM To assess the utility of clinical and biochemical variables and prognostic scores in predicting mortality and the need for LT in patients with acute HAV infection.METHODS We conducted a retrospective case series of all patients hospitalized at Medica Sur Clinic between 2018 and 2024 who were positive for immunoglobulin M antibodies for HAV.Clinical and laboratory data were collected from patients’electronic medical records.Continuous variables were summarized as the means±SD or median and interquartile range and compared using Student’s t-test or the Mann-Whitney U test,as appropriate.Categorical variables were expressed as frequencies and percentages and compared using the χ2 test or Fisher’s exact test.RESULTS A total of 69 patients with HAV infection(mean age,38±11 years;65%male)were included.14%of patients had a history of hepatic steatosis,10%had type 2 diabetes,and 45%were smokers.Acute liver injury was observed in 47 patients(68%),acute liver failure was detected in five patients(7.2%),and mortality or LT occurred in three patients(4.3%;two deaths and one transplant).Patients who died or required orthotopic LT were older,and they had higher heart and respiratory rates at admission.These patients additionally exhibited greater liver dysfunction,including higher bilirubin and transaminase levels,prolonged coagulation times,lower sodium and albumin levels,and worse albumin-bilirubin scores.Severity scores[model for end-stage liver disease(MELD),MELD with sodium,MELD version 3.0]were significantly higher in patients with complications than in those without complications.CONCLUSION Advanced age,elevated severity,and higher albumin-bilirubin scores emerged as predictors of adverse outcomes in patients with HAV infection,and consideration of these factors could guide the need for more intensive monitoring strategies.These findings highlight the importance of incorporating prognostic scoring systems into routine clinical evaluation to improve outcomes in high-risk patients. 展开更多
关键词 Hepatitis A virus Acute liver failure Liver transplantation Mortality risk factors Predictors Risk stratification Mexico Prognostic scoring systems Liver function tests
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Uncovering silent carriers:Hematological insights and viral burden in incidentally detected hepatitis B virus infection 认领 引用
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作者 Manisha M Ratnaparkhi Chanda R Vyawahare +2 位作者 Parag J Ratnakar Nageswari R Gandham Poonam V Suryawanshi 《World Journal of Hepatology》 2026年第1期152-161,共10页
BACKGROUND Hepatitis B Virus(HBV)remains a global public health challenge,affecting over 296 million people,many of whom are asymptomatic.Incidentally diagnosed carriers provide a critical window for early interventio... BACKGROUND Hepatitis B Virus(HBV)remains a global public health challenge,affecting over 296 million people,many of whom are asymptomatic.Incidentally diagnosed carriers provide a critical window for early intervention and prevention.Understanding their hematological profile and viral burden can help inform risk assessment and clinical management.AIM To evaluate hematological parameters and HBV viral load in incidentally detected asymptomatic hepatitis B surface antigen positive patients during routine health screenings.METHODS A cross-sectional observational study was conducted from June 2024 to March 2025 at Dr.D.Y.Patil Medical College,Hospital and Research Centre a tertiary care hospital in Pune,Maharashtra,India,involving 100 hepatitis B surface antigen-positive patients and 20 healthy controls.Hematological and liver function parameters were assessed,and quantitative HBV DNA analysis was performed using real-time polymerase chain reaction.Statistical analysis was conducted using GraphPad Prism v8.0.RESULTS Marked variations were detected in hemoglobin levels(P2000 IU/mL was found in 17 patients,and<2000 IU/mL in 24 patients.Viral load positively correlated with conjugated bilirubin,serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,and alkaline phosphatase,and negatively with albumin and the albumin-globulin ratio.CONCLUSION Incidentally detected HBV infections present an opportunity for early disease detection.Hematological and viral markers can guide clinical decisions.Routine screening and contact tracing are essential strategies to control HBV transmission and progression. 展开更多
关键词 Hepatitis B Hepatitis B virus deoxyribonucleic acid quantification Hematological biomarkers Liver function tests Viral load Subclinical hepatic injury
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From morphology to function:Advances in multimodal imaging for pulmonary function prediction 认领 引用
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作者 Yaoting Zhu Shuhong Guan +9 位作者 Jianxiong Gao Yan Sun Jinbao Feng Yuhao Fan Mengyue Hu Yunmei Shi Yuetao Wang Rong Niu Jun Zhou Xiaonan Shao 《Intelligent Oncology》 CAS 2026年第2期66-77,共12页
Pulmonary function test(PFT)is a vital noninvasive method for evaluating respiratory system function and is widely used in the diagnosis,surgical risk assessment,and prognostic prediction of chronic airway diseases an... Pulmonary function test(PFT)is a vital noninvasive method for evaluating respiratory system function and is widely used in the diagnosis,surgical risk assessment,and prognostic prediction of chronic airway diseases and interstitial lung diseases.In 2021,the American Thoracic Society and the European Respiratory Society updated their pulmonary function interpretation guidelines,choosing to adopt z-scores instead of percentage of predicted forced expiratory volume in 1 second(FEV1),thereby significantly improving sensitivity and prognostic evaluation.However,conventional PFT relies on patient cooperation and is limited in its ability to effectively capture the heterogeneity of localized lesions.In recent years,the use of multimodal medical imaging in pulmonary function prediction has progressed rapidly.When combined with radiomics and deep learning techniques,these imaging methods enable more accurate and quantitative functional assessments.This review introduces that pulmonary function assessment should integrate multimodal imaging features with clinical functional indicators.This approach establishes cross-scale linkages between morphology and function and provides new perspectives for the early screening of high-risk individuals with accelerated pulmonary aging,evaluating the effectiveness of interventions,and enabling personalized intervention strategies.We review the classification systems and clinical value of PFT,discuss the advances and limitations of multimodal imaging in predicting lung function,and explore future directions in standardized data acquisition and multicenter validation to promote precise pulmonary function assessment and clinical application. 展开更多
关键词 Pulmonary function test Multimodal imaging Radiomics Deep learning Pulmonary function prediction
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Excessive dynamic airway collapse:A condition behind the veil 认领 引用
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作者 Vivek Paudyal Rubi Thapa +4 位作者 Asmita Itani Munish Sharma Rabindra Rayamajhi Iqbal Ratnani Salim Surani 《World Journal of Methodology》 2026年第1期80-91,共12页
Excessive dynamic airway collapse(EDAC)is characterized by weakness in the posterior membranous wall of the airway,which results in more than 50%narrowing of the central airway lumen during expiration.EDAC differs fro... Excessive dynamic airway collapse(EDAC)is characterized by weakness in the posterior membranous wall of the airway,which results in more than 50%narrowing of the central airway lumen during expiration.EDAC differs from tracheobronchomalacia,which involves the weakening of the cartilage rather than the membranous wall.EDAC poses a diagnostic challenge due to overlapping symptoms with chronic obstructive pulmonary disease and asthma,including dyspnea,cough,and wheezing.The diagnosis of EDAC relies on dynamic airway imaging techniques,including bronchoscopy,dynamic computed tomography,dynamic magnetic resonance imaging,and endobronchial ultrasound,to assess airway collapse during expiration.Pulmonary function testing helps in ruling out obstructive lung disease.Treatment includes medical management of underlying comorbidities,pulmonary rehabilitation,and,in severe cases,bronchoscopyguided stenting of the airway or tracheobronchoplasty.This mini-review discusses pathophysiology,diagnostic challenges,and evolving treatment strategies for EDAC,highlighting the need for increased clinical awareness and targeted therapies. 展开更多
关键词 Excessive dynamic airway collapse Tracheobronchomalacia Obstructive pulmonary disease Pulmonary function test Bronchoscopy Dynamic computed tomography Stenting Tracheobronchoplasty
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Pancreatic function testing: Here to stay for the 21st century 认领 引用 被引量：9
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作者 John G Lieb II Peter V Draganov 《World Journal of Gastroenterology》 SCIE CAS 2008年第20期3149-3158,共10页
The diagnosis of Chronic Pancreatitis （CP） is based on the detection of abnormal structure or function of the diseased pancreas. The pancreatic function tests more accurately determine the presence of CP than tests ... The diagnosis of Chronic Pancreatitis （CP） is based on the detection of abnormal structure or function of the diseased pancreas. The pancreatic function tests more accurately determine the presence of CP than tests of structure, especially for early stage disease. The function tests can be divided into two categories： non- invasive and invasive. The invasive ＂tube＂ tests can reliably detect mild, early CP, but are only available at a few referral centers and tend to be poorly tolerated by patients. The non-invasive tests are easy to obtain, but tend to perform poorly in patients with early, mild disease. Therefore, no one test is useful in all clinical situations, and a detailed understanding of the rational, pathophysiologic basis, strengths, and limitations of various tests is needed. This review highlights the role of various pancreatic function tests in the diagnosis of CP including fecal fat analysis, fecal elastase, fecal chymotrypsin, serum trypsin, the secretin stimulation test, the cholecystokinin （CCK） stimulation test, the combined secretin-CCK stimulation test, the intraductal and endoscopic secretin stimulation tests, and the functional magnetic resonance imaging of the pancreas after secretin stimulation. 展开更多
关键词 Pancreatic function testing Secretinstimulation test CCK stimulation test Fecal elastase Endsocopic secretin stimulation test Chronic pancreatitis
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Update on endoscopic pancreatic function testing 认领 引用 被引量：7
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作者 Tyler Stevens Mansour A Parsi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第35期3957-3961,共5页
Hormone-stimulated pancreatic function tests (PFTs) are considered the gold standard for measuring pancreatic exocrine function. PFTs involve the administration of intravenous secretin or cholecystokinin, followed by ... Hormone-stimulated pancreatic function tests (PFTs) are considered the gold standard for measuring pancreatic exocrine function. PFTs involve the administration of intravenous secretin or cholecystokinin, followed by collection and analysis of pancreatic secretions. Because exocrine function may decline in the earliest phase of pancreatic fibrosis, PFTs are considered accurate for diagnosing chronic pancreatitis. Unfortunately, these potentially valuable tests are infrequently performed except at specialized centers, because they are time consuming and complicated. To overcome these limitations, endoscopic PFT methods have been developed which include aspiration of pancreatic secretions through the suction channel of the endoscope. The secretin endoscopic pancreatic function test (ePFT) involves collection of duodenal aspirates at 15, 30, 45 and 60 min after secretin stimulation. A bicarbonate concentration greater than 80 mmol/L in any of the samples is considered a normal result. The secretin ePFT has demonstrated good sensitivity and specificity compared with various reference standards, including the "Dreiling tube" secretin PFT, endoscopic ultrasound, and surgical histology. Furthermore, a standard autoanalyzer can be used for bicarbonate analysis, which allows the secretin ePFT to be performed at any hospital. The secretin ePFT may complement imaging tests like endoscopic ultrasound (EUS) in the diagnosis of early chronic pancreatitis.This paper will review the literature validating the use of ePFT in the diagnosis of exocrine insufficiency and chronic pancreatitis. Newer developments will also be discussed, including the feasibility of combined EUS/ ePFT, the use of cholecystokinin alone or in combination with secretin, and the discovery of new protein and lipid pancreatic juice biomarkers which may complement traditional fluid analysis. 展开更多
关键词 Endoscopic pancreatic function test Pancreatic function testing Chronic pancreatitis Pancreatic exocrine insufficiency
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Technological insights:combined impedance manometry for esophageal motility testing-current results and further implications 认领 引用 被引量：2
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作者 Huan Nam Nguyen Gerson Ricardo Souza Domingues Frank Lammert 《World Journal of Gastroenterology》 SCIE CAS 2006年第39期6266-6273,共8页
This review focuses on current aspects of the novel technology of combined impedance manometry for esophageal motility testing. It presents methodological features, summarizes current results and discusses implication... This review focuses on current aspects of the novel technology of combined impedance manometry for esophageal motility testing. It presents methodological features, summarizes current results and discusses implications for further research. The combined technique assesses simultaneously bolus transport and associated peristalsis, thus allowing detailed analysis of the relationships between bolus transit and esophageal motility. Recent studies demonstrate that combined impedance manometry provides important additional information about esophageal motility as compared to conventional manometry: (1) monitoring of bolus transport patterns, (2) calculation of bolus transit parameters, (3) evaluation of bolus clearance, (4) monitoring of swallow associated events such as air movement and reflux, and (5) investigation of the relationships between bolus transit and LES relaxation. Studies with healthy subjects have identified several useful parameters for comprehensive assessment of eosphageal function. These parameters were found to be pathological in patients with classical achalasia, mild GERD, and ineffective esophageal motility. The technology of combined impedance manometry provides an important new tool for esophageal function testing, advancing both clinical and basic research. However, several important issues remain to be standardized to make the technique suitable for widely clinical use. 展开更多
关键词 Combined impedance manometry Esophageal function testing Review
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Semen analysis in 21st century medicine: the need for sperm function testing 认领 引用 被引量：27
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作者 Dolores J. Lamb 《Asian Journal of Andrology》 SCIE CAS 2010年第1期64-70,共7页
Sperm function testing, once commonly performed for the infertile couple before employing assisted reproductive technology （ART）, has fallen out of favour in many reproductive medicine centers throughout the world. ... Sperm function testing, once commonly performed for the infertile couple before employing assisted reproductive technology （ART）, has fallen out of favour in many reproductive medicine centers throughout the world. Indeed, the most recent addition of the ＇World Health Organisation （WHO） Laboratory Manual for the Examination and Processing of Hu- man Semen＇ now groups many of these procedures into a section termed Research Procedures. In large part, this reflects the current clinical practice of bypassing the in-depth evaluation of the male partner, while assuming that if a spermatozoon can be found for intracytoplasmic sperm injection （ICSI）, it must be a healthy cell capable of achieving fertilization. Never- theless, sperm function testing can provide valuable clinical insights into defects causing male infertility. Admittedly, in some cases, functional sperm deficiencies can be overcome using an ART. In other cases, couples will be empowered by the knowledge of the cause of their infertility, and for some couples, perhaps even the likelihood of ICSI success （relative to the spermatozoa）. The knowledge allows them to make truly informed reproductive decisions, including （perhaps） the de- cision to seek donor insemination, to adopt or to remain childless. Knowledge of the cause of their infertility may provide closure for couples and a sense of confidence regarding their choice of reproductive treatment. 展开更多
关键词 semen analysis sperm function tests
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Correlation of diaphragm thickness with pulmonary function test in Parkinson’s disease 认领 引用
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作者 Zeliha Cosgun Emine Afsin +3 位作者 Ramazan Kurul Sule Aydin Turkoglu Melike Elif Kalfaoglu Gulali Aktas 《World Journal of Methodology》 2026年第3期251-258,共8页
BACKGROUND Dopaminergic neurons are lost in Parkinson’s disease(PD),a degenerative neurological condition.While the effects of PD on motor functions are well understood,its impact on respiratory function is less clea... BACKGROUND Dopaminergic neurons are lost in Parkinson’s disease(PD),a degenerative neurological condition.While the effects of PD on motor functions are well understood,its impact on respiratory function is less clear.In PD patients with suspicious pulmonary symptoms,the presence and degree of impairment in lung function often cannot be optimally assessed through pulmonary function tests(PFTs)due to the patients'neurological symptoms.AIM To examine the relationship between diaphragmatic thickness as determined by ultrasonography(US)and conventional PFTs in PD patients.Additionally,we evaluated the potential use of diaphragmatic thickness as an alternative measure for assessing respiratory function in PD patients who are unable to perform PFTs.METHODS A total of 43 PD patients who presented to the clinics between June 15,2021,and June 30,2022,were included.Patients with coronavirus disease 2019 infection history,conditions affecting diaphragmatic motility,recent thoracic or abdominal surgery,or imaging showing restrictive masses were excluded.Demographic data,disease duration,Hoehn-Yahr stage,and medication use were recorded.PFTs were used to evaluate forced vital capacity,forced expiratory volume in the first second,and other parameters,while US was used to measure diaphragmatic thickness.Breathlessness was assessed using the modified medical research council dyspnea scale.RESULTS Significant correlations were found between peak expiratory flow(PEF)and diaphragm fraction(P=0.019),as well as between PEF percentage and diaphragmatic thickness during expiration(P=0.023).In early-stage PD,diaphragmatic thickness during inspiration correlated with oxygen saturation(P=0.048).In advanced-stage PD,PEF and PEF%were significantly correlated with diaphragm thickness during expiration[r=0.405,P=0.049(for PEF);r=0.463,P=0.023(for PEF%)]and diaphragm fraction[r=-0.476,P=0.019(for PEF);r=-0.617,P=0.001(for PEF%)].CONCLUSION Present study assessed the relationship between PFTs and diaphragmatic thickness in PD patients.Diaphragmatic thickness measured by US was found to correlate with certain PFT parameters,suggesting it could be used as an alternative measure for assessing respiratory function in Parkinson’s patients who have difficulty performing PFTs. 展开更多
关键词 Parkinson’s disease Ultrasonography Diaphragmatic thickness Pulmonary function test Respiratory function
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Lifespan Estimates of Solutions to the Tricomi Equation with Memory Terms 认领 引用
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作者 YANG Jie YAO Jiangyan 《应用数学》 北大核心 2026年第2期605-623,共19页
The main purpose of this paper is to investigate the singularities of solutions to the single Tricomi equation with derivative term and combined memory term.In addition,the blow-up of the solution to the weakly couple... The main purpose of this paper is to investigate the singularities of solutions to the single Tricomi equation with derivative term and combined memory term.In addition,the blow-up of the solution to the weakly coupled system with memory term is also considered,where one is a power nonlinear term and the other is a derivative nonlinear term.Upper bound lifespan estimates of solution are obtained in the sub-critical by utilizing the test function method and iteration technique.The innovation of this paper focuses on the lifespan estimates of the solutions,which extends the well-known Strauss and Glassey conjectures. 展开更多
关键词 Tricomi equation Memory term Semilinear weakly coupled system Test function method Iteration method
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THE SIGNIFICANCE OF TESTING PREOPERATIVE VISUAL FUNCTION IN CATARACT USING LASER INTERFEROMETRIC VISUAL ACUITY AND ERG 认领 引用 被引量：2
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作者 De-Zheng Wu Lezheng Wu Xijing Xu Hui Chen Taiqing Luo Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060, China 《眼科学报》 CAS 1991年第1期21-24,共4页
Tests of preoperative visual function and prediction of postoperative E chart visual acuity(ECVA) using laser interferometric visual acuity(LIVA) and electroretinogram(ERG) were performed in 16 cases(19 eyes) of catar... Tests of preoperative visual function and prediction of postoperative E chart visual acuity(ECVA) using laser interferometric visual acuity(LIVA) and electroretinogram(ERG) were performed in 16 cases(19 eyes) of cataract. The results showed that the coincident rate between preoperative LIVA and postoperative ECVA was 63.2%, and there was a parallel correlation between preoperative amplitude of photopic ERG b-wave and postoperative ECVA in 79.0% of the eyes. Comparing these two methods, the test of LIVA ... 展开更多
关键词 THE SIGNIFICANCE OF TESTING PREOPERATIVE VISUAL FUNCTION IN CATARACT USING LASER INTERFEROMETRIC VISUAL ACUITY AND ERG
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Leap Motion-based virtual reality training for improving motor functional recovery of upper limbs and neural reorganization in subacute stroke patients 认领 引用 被引量：26
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作者 Zun-rong Wang Ping Wang +3 位作者 Liang Xing Li-ping Mei Jun Zhao Tong Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第11期1823-1831,共9页
Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patien... Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs （arms） because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers. Therefore, the present study explored the effects of a Leap Motion-based virtual reality system on subacute stroke. Twenty-six subacute stroke patients were assigned to an experimental group that received virtual reality training along with conventional occupational rehabilitation, and a control group that only received conventional rehabilitation. The Wolf motor func- tion test （WMFT） was used to assess the motor function of the affected upper limb; functional magnetic resonance imaging was used to measure the cortical activation. After four weeks of treatment, the motor functions of the affected upper limbs were significantly improved in all the patients, with the improvement in the experimental group being significantly better than in the control group. The action perfor- mance time in the WMFT significantly decreased in the experimental group. Furthermore, the activation intensity and the laterality index of the contralateral primary sensorimotor cortex increased in both the experimental and control groups. These results confirmed that Leap Motion-based virtual reality training was a promising and feasible supplementary rehabilitation intervention, could facilitate the recovery of motor functions in subacute stroke patients. The study has been registered in the Chinese Clinical Trial Registry （registration number： ChiCTR-OCH- 12002238）. 展开更多
关键词 nerve regeneration virtual reality Wolf motor function test functional magnetic resonance imaging stroke Leap Motion rehabilitation upper limb neural reorganization neural regeneration
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Architecture and Methodology of Unit Testing Embedding Pair-Wise Mode for Small Team 认领 引用 被引量：3
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作者 Mengqing TanLi Ying Zhang Yulin Wang 《Journal of Software Engineering and Applications》 2022年第11期385-405,共21页
In this paper, the new organization for unit testing embedding pair-wise mode is proposed with the core thought focused on the cooperation of programmer and tester by “cross-testing”. The typical content of unit tes... In this paper, the new organization for unit testing embedding pair-wise mode is proposed with the core thought focused on the cooperation of programmer and tester by “cross-testing”. The typical content of unit testing for the new organizing mode should have three aspects, including self-checking, cross-testing and independent-testing. For cross-testing, executing “pair-wise” mode, mainly tackles data testing, function testing and state testing, which function testing must be done by details and state testing must be considered for completeness. With the specializing of independent-testing, it should be taken as more rigid testing without arbitrariness. Consequently, strategy and measure are addressed for data testing focusing on boundary testing and function/state testing. And organizing method of procedure and key points of tackling unit testing are investigated for the new organizing mode. In order to assess the validity of our study and approach, a series of actual examples are demonstrated for GUI software. The result indicates that the execution of unit testing for the new organizing mode is effective and applicable. 展开更多
关键词 Unit Testing Organizing Architecture Pair-Wise Mode Cross-Testing Data Testing Function/State Testing Boundary Testing Small Team
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Implementation of a Subjective Visual Vertical and Horizontal Testing System Using Virtual Reality 认领 引用
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作者 Sungjin Lee Min Hong +1 位作者 Hongly Va Ji-Yun Park 《Computers, Materials & Continua》 SCIE EI 2021年第6期3669-3679,共11页
Subjective visual vertical(SVV)and subjective visual horizontal(SVH)tests can be used to evaluate the perception of verticality and horizontality,respectively,and can aid the diagnosis of otolith dysfunction in clinic... Subjective visual vertical(SVV)and subjective visual horizontal(SVH)tests can be used to evaluate the perception of verticality and horizontality,respectively,and can aid the diagnosis of otolith dysfunction in clinical practice.In this study,SVV and SVH screen version tests are implemented using virtual reality(VR)equipment;the proposed test method promotes a more immersive feeling for the subject while using a simple equipment configuration and possessing excellent mobility.To verify the performance of the proposed VR-based SVV and SVH tests,a reliable comparison was made between the traditional screen-based SVV and SVH tests and the proposed method,based on 30 healthy subjects.The average results of our experimental tests on the VR-based binocular SVV and SVH equipment were−0.15◦±1.74 and 0.60◦±1.18,respectively.The proposed VR-based method satisfies the normal tolerance for horizontal or vertical lines,i.e.,a±3◦error,as defined in previous studies,and it can be used to replace existing test methods. 展开更多
关键词 Subjective visual vertical subjective visual horizontal virtual reality unity3D FOVE HMD vestibular function tests diagnostic equipment
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