Deep tight sandstone reservoirs,which are characterized by complex features including compaction,consolidation,superposition of multi-stage channel sand bodies,and differential sedimentary infill,usually present diffe...Deep tight sandstone reservoirs,which are characterized by complex features including compaction,consolidation,superposition of multi-stage channel sand bodies,and differential sedimentary infill,usually present different pore-permeability characteristics and evident heterogeneity.Tight sandstone reservoirs exhibiting low to ultra-low permeability can be categorized into various types of effective reservoirs according to porosity and permeability parameters as key assessment indicators.Therefore,within the macro background of low permeability,the development areas presenting relatively high porosity and permeability(sweet spots)are the primary targets for investigation.However,distinguishing these types of effective reservoirs remains difficult due to the inadequate discriminative power of single elastic parameters,which introduces challenges for direct pre-stack seismic prediction.To address this concern,we propose a method for defining effective reservoir indicators by integrating reservoir physical parameters and establishing a statistical rock physical relationship between the indicators and elastic impedance.This technique constructs a seismic prediction framework for multiple types of effective reservoirs in deep tight sandstones on the basis of the Bayesian probabilistic inversion strategy.Results from model testing and field data applications validate the strong potential of the method for exploration practice.展开更多
To calculate the biological zero and the effective accumulated temperature(EAT)for gonadal development in one-and two-year-old diploid and tetraploid Pacific oysters(Crassostrea gigas),four indoor heating experiments ...To calculate the biological zero and the effective accumulated temperature(EAT)for gonadal development in one-and two-year-old diploid and tetraploid Pacific oysters(Crassostrea gigas),four indoor heating experiments were carried out in2022-2024.The biological zeros of diploids and tetraploids were 7.84℃and 7.45℃,respectively.The EAT in diploids was lower than that in tetraploids,at 389.05℃×d and 546.95℃×d,respectively.Histological analysis indicated that gonadal development was more rapid in diploids than in tetraploids.Simultaneously,one-and two-year-old diploid and tetraploid oysters had the same EAT.The proportion of females dominated all four study groups,especially the tetraploids.Age and ploidy did not significantly influence the cumulative survival rate(CSR).Gonadal development and warm temperatures may be the primary causes of mortality.The incremental survival rate(ISR)during the first half of the entire experimental cycle(ISR1)was markedly higher than that of the second half(ISR2)in both the diploid and tetraploid groups.These results suggest that one-and two-year-old tetraploid oysters could be used for the large-scale production of triploids by providing indoor heating.展开更多
The effective density(ρeff)is a key parameter of black carbon-containing(BCc)particles and is related to their morphologies,deposition processes,and optical properties.In this study,a tandem system was established...The effective density(ρeff)is a key parameter of black carbon-containing(BCc)particles and is related to their morphologies,deposition processes,and optical properties.In this study,a tandem system was established and used to determine theρeffof ambient BCc particles.The results showed that theρeffdistribution of ambient BCc particles exhibited a bimodal pattern with a left peak located at 0.69 g cm-3and a right peak at 1.45 g cm-3.The averageρeffof BCc particles over the entire observation period was 1.38 g cm-3.Theρeffof BCc particles showed a clear diurnal pattern with a relatively stable distribution at night and large variations during the daytime.Theρeffvalue was demonstrated to be a good indicator of BCc particle morphology.BCc particles became more regular with increasingρeffrelated to the increasing coating thickness.More coating led to morphological restructuring of BCc particles.The restructuring could be more efficient under high relative humidity conditions.The observed data were further used in a dry deposition scheme,and it was found that the dry deposition velocity of fresh emitted BCc could be largely influenced by its irregular shape.This study reveals the presence of a significant amount of low-density/irregularly shaped black carbon in the environment with rapid morphological changes occurring during the daytime and highlights the need to consider morphological influences in future research on the physicochemical properties of BCc.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
Modern battlefields exhibit high dynamism,where traditional static weighting methods in combat effectiveness assessment fail to capture real-time changes in indicator values,leading to limited assessment accuracy—esp...Modern battlefields exhibit high dynamism,where traditional static weighting methods in combat effectiveness assessment fail to capture real-time changes in indicator values,leading to limited assessment accuracy—especially critical in scenarios like sudden electronic warfare or degraded command,where static weights cannot reflect the operational value decay or surge of key indicators.To address this issue,this study proposes a dynamic adaptive weightingmethod for evaluation indicators based onG1-CRITIC-PIVW.First,theG1(Sequential Relationship Analysis Method)subjective weighting method—translates expert knowledge into indicator importance rankings—leverages expert knowledge to quantify the relative importance of indicators via sequential relationship ranking,while the CRITIC(Criteria Importance Through Intercriteria Correlation)objective weighting method—derives weights from data characteristics by integrating variability and inter-correlations—calculates weights by integrating indicator variability and inter-indicator correlations,ensuring data-driven objectivity.These two sets of weights are then fused using a deviation coefficient optimization model,minimizing the squared deviation from a reference weight and adjusting the fusion coefficient via Spearman’s rank correlation to resolve potential conflicts between subjective and objective judgments.Subsequently,the PIVW(Punishment-Incentive VariableWeight)theory—adapts weights to realtime indicator performance via penalty/incentive rules—is applied for dynamic adjustment.Scenario-specific penalty λ1 and incentive λ2 thresholds are set based on operational priorities and indicator volatility,penalizing indicators with values below λ1 and incentivizing those exceeding λ2 to reflect real-time indicator performance.Experimental validation was conducted using an Air Defense and Anti-Missile(ADAM)system effectiveness assessment framework,with data covering 7 indicators across 3 combat scenarios.Results show that compared to static weighting methods,the proposed method reduces MAE(Mean Absolute Error)by 15%-20% and weighted decision error rate by 84.2%,effectively reducing overestimation/underestimation of combat effectiveness in dynamic scenarios;compared to Entropy-TOPSIS,it lowers MAE by 12% while achieving a weighted Kendall’sτconsistency coefficient of 0.85,ensuring higher alignment with expert judgment.This method enhances the accuracy and scenario adaptability of effectiveness assessment,providing reliable decision support for dynamic battlefield environments.展开更多
The eff ective elastic thickness(Te)of the lithosphere serves as a critical parameter for characterizing the mechanical strength and structural response of the lithosphere.In this study,Te and the initial load r...The eff ective elastic thickness(Te)of the lithosphere serves as a critical parameter for characterizing the mechanical strength and structural response of the lithosphere.In this study,Te and the initial load ratio(F)were jointly estimated for the North China Craton and its surrounding regions using a combined admittance–coherence inversion approach within a Bayesian framework,incorporating Markov Chain Monte Carlo(MCMC)sampling to quantify parameter uncertainties.The results reveal signifi cant lateral variations in Te across the study area,ranging from 5 to 66 km.High Te values(30–66 km)are observed beneath the Ordos Block,indicating a stable and mechanically strong lithosphere.In contrast,the North China Block exhibits low Te values(5–25 km),suggesting lithospheric thinning and mechanical weakening.These fi ndings are further supported by seismicity patterns,lithosphere–asthenosphere boundary(LAB)depth,and mantle composition(Mg#),all of which demonstrate a strong correlation between Te and lithospheric structure and dynamic processes.Low-Te regions are associated with high seismic activity and a“thin–hot–weak”lithospheric signature,whereas high-Te regions exhibit a“thick–cold–strong”stable configuration.It is proposed that the destruction of the North China Craton has been primarily driven by asthenospheric thermal perturbation,following a geodynamic evolution involving“thermal disturbance–lithospheric thinning–compositional modification–mechanical weakening.”This study provides new mechanical constraints on the geodynamic processes responsible for craton destruction.展开更多
The process of exploiting natural gas hydrates involves complex phase changes,multiphase seepage,and intricate heat transfer processes.A comprehensive understanding of the heat transfer characteristics in natural gas ...The process of exploiting natural gas hydrates involves complex phase changes,multiphase seepage,and intricate heat transfer processes.A comprehensive understanding of the heat transfer characteristics in natural gas hydrate reservoirs is crucial for enhancing their exploitation efficiency.However,at present,there is a limited amount of research on the effective thermal conductivity(ETC)of complex component systems in marine natural gas hydrate reservoirs,which directly restricts the optimization of natural gas hydrate exploitation technologies in marine sediments.This study proposes a method to predict the ETC of marine natural gas hydrate reservoirs based on machine learning(ML).This method constructed an ETC dataset under the conditions including reservoir environmental characteristics(temperature,pressure,salt concentration),reservoir physical property characteristics(quartz sand content,montmorillonite content,illite content),and reservoir structural characteristics(initial water saturation,hydrate saturation,component phase).In this work,a dataset containing 200 data points from various literature was compiled.Six ML models were employed to predict the ETC of the reservoirs based on this dataset with a high-precision ETC prediction model being derived through ML training.The SHapley Additive ex Planations(SHAP)method was subsequently applied to conduct interpretability analysis on the model prediction results.This has not only confirmed the model's reliability but also quantitatively highlighted the sensitivity of key reservoir characteristics to ETC.The research results show that the Gradient Boosting Decision Tree(GBDT)model is particularly effective for predicting the ETC of marine natural gas hydrate reservoirs,as evidenced by its coefficient of determination(R2)exceeding 0.95.Sensitivity analysis reveals that the reservoir's salt concentration and illite content are the primary determinants of its overall ETC.The prediction method established in this study can provide effective technical support for the real-time evaluation of reservoir ETC during the on-site exploitation of marine natural gas hydrate reservoirs.展开更多
A Moho topography admittance method with high-precision Moho depth inversion for calculating the effective elastic thickness(Te)of the oceanic lithosphere was established by comprehensively considering the effects ...A Moho topography admittance method with high-precision Moho depth inversion for calculating the effective elastic thickness(Te)of the oceanic lithosphere was established by comprehensively considering the effects of surface and subsurface loading.The accuracy of the method was verified through model testing and applied to the Northeast Pacific region.Te values in the study area range from 5 to 60 km,showing distinct spatial variations:regions with fracture zones such as Sedna,Surveyor,and Mendocino exhibit Te values generally<20 km.In thermally anomalous regions,the predictive capability of the standard thermal cooling model is significantly limited.Mantle plume-induced thermal anomalies disrupt the expected correlation between current heat flow and lithospheric age,resulting in a minimal correlation between Te and contemporary heat flow measurements.Earthquake distribution analysis shows that seismic events(M≥4)in the study area are concentrated within a Te of 10-60 km,of which 20% occur at Te values of 25-30 km.The Te-loading-age relationship along the Hawaii-Emperor Seamount Chain shows partial consistency with the standard thermal cooling model:in the Hawaii Ridge region,a synchronous decrease of Te with loading age;in the Emperor Seamount region,Te decreases from 47 to 10 km as the loading age decreases from 90 to 30 Ma,with a considerably lower slope than that of the Hawaii Ridge.However,the central seamounts exhibit an anomalous increase in Te(1-22 km),significantly deviating from the standard model.This study reveals that Te values cannot be predicted solely based on loading age,but are jointly influenced by multiple physical mechanisms including regional tectonic history,thermotectonic age,and crust-mantle decoupling induced by mantle plume thermal anomalies.In thermally anomalous regions,the applicability of the standard thermal cooling model is significantly limited,and predictions of lithospheric strength require region-specific corrections based on the regional tectonic background.展开更多
A primitive problem of predicting effective properties of composites is open boundary conditions.In this paper,Eshelby's transformation field method(TFM)is developed to solve the open boundary problem of two-phase...A primitive problem of predicting effective properties of composites is open boundary conditions.In this paper,Eshelby's transformation field method(TFM)is developed to solve the open boundary problem of two-phase composites having an arbitrary geometry of inclusion.The inhomogenous transformation fields are introduced in the composite system to cope with the complex interface boundary-value problem.Furthermore,the open boundary problem is solved by a Hermite polynomial,which is used to express the transformation fields and the perturbation fields.As an example,the formulas of calculating effective dielectric property of two-dimensional isotropic dielectric composites having open boundary conditions are derived by TFM.The validity is verified by comparing the effective responses estimated by TFM with the exact solutions of the dilute limit,and good agreements are obtained.The results show that TFM is valid to solve the open boundary problem of composites having complex geometric inclusions.展开更多
Offshore thin interbedded reservoirs are characterized by frequent alternation of sandstone and mudstone,strong vertical heterogeneity,and complex fracture cross-layer propagation mechanisms,which constitute a key cha...Offshore thin interbedded reservoirs are characterized by frequent alternation of sandstone and mudstone,strong vertical heterogeneity,and complex fracture cross-layer propagation mechanisms,which constitute a key challenge constraining efficient hydraulic fracturing stimulation.This study investigates a typical thin interbedded sandstone reservoir,quantitatively classifying the reservoir into three representative models based on adjacent layer thickness ratio:homogeneous-dominated,sand-dominated,and mudstone-dominated types.Using the Planar Three-Dimensional(PL3D)fracture propagation model,235 simulation scenarios were systematically analyzed to reveal the controlling effects of interlayer stress difference and pumping rate on fracture cross-layer propagation capability.Results indicate that interlayer stress difference is the dominant controlling factor for fracture cross-layer propagation,with 8 MPa identified as the critical threshold for thin interbedded cross-layer propagation.When the stress contrast exceeds this value,fractures transition from three-dimensional penetration to single-layer horizontal propagation.Increasing pumping rate primarily drives horizontal fracture extension,constrained by the diminishing marginal effect of net pressure,and an optimal pumping rate range exists for fracture conductivity.Under high stress contrast conditions,simply increasing pumping rate cannot overcome the stress barrier.A quantitative mapping relationship between thin interbedded reservoir models and fracture geometries was systematically established,where fracture geometry evolution controls the spatial distribution characteristics of conductivity and constrains long-term productivity.A multi-dimensional evaluation chart integrating vertical fracture connectivity and stimulated reservoir area efficiency was constructed,delineating the quantitative boundaries of fracture cross-layer propagation capability under different geological and engineering conditions.Long-term development simulation demonstrates that three-dimensional cross-layer stimulation increases cumulative oil production by 2.7 times compared to single-layer stimulation.The research findings provide a theoretical basis and technical support for hydraulic fracturing parameter optimization and three-dimensional stimulation design in offshore thin interbedded reservoirs.展开更多
Multiferroic composites hold great promise in electronic devices because of their exceptional magnetoelectric coupling effects,and multilayer core-shell nanofibers are considered as ideal carriers for achieving high-p...Multiferroic composites hold great promise in electronic devices because of their exceptional magnetoelectric coupling effects,and multilayer core-shell nanofibers are considered as ideal carriers for achieving high-performance responses.However,existing theories often assume perfectly circular fiber cross-sections while neglecting the interfacial effects.This makes it difficult to accurately characterize the elliptical cross-sections and nanoscale interface properties commonly observed in practical fabrication.To address this issue,this study establishes a theoretical model for multilayer multiferroic nanofiber composites.The model simultaneously accounts for both the fiber shape and interfacial effects.Using the generalized self-consistency method and complex function approach,this work further derives analytical solutions for the effective magneto-electric-elastic(MEE)moduli.Based on this model,the study systematically investigates the influence of the coated fiber shape,fiber size,coated fiber volume fraction,and inner-to-outer coating thickness ratio on the composite's effective MEE moduli.The findings reveal the synergistic mechanism,by which the elliptical fiber shape and multiple interfacial effects regulate the magnetoelectric anisotropy,thereby providing crucial theoretical guidance for designing the structure of high-performance multiferroic nanocomposites and optimizing their performance.展开更多
The variation of the effective mass m*of carrier is often overlooked in experimental studies on quantum oscillations and Kohler's rule.Here,we report the magnetotransport properties of La3Sc Bi5and reveal...The variation of the effective mass m*of carrier is often overlooked in experimental studies on quantum oscillations and Kohler's rule.Here,we report the magnetotransport properties of La3Sc Bi5and reveal the changing m*in it.The temperature and magnetic field dependence of m*follows the power-law scaling behavior at low temperature and leads to the failure of conventional analysis,which should not be ignored.In the analysis of the thermal factor and Dingle plot of de Haas-van Alphen oscillation in La3ScBi5,satisfactory fitting results can be obtained after considering the correction of m*.We have also applied this method to Sr1-yMn1-zSb2,solving the remaining fitting problem in previous reports.Moreover,the magnetoresistance(MR)of La3ScBi5has been found to violate Kohler's rule.Although the extended Kohler's rule is applicable to high-temperature MR data,it does not scale the low-temperature data well.We further modified the extended Kohler's rule by introducing m*,and subsequently scaled the low-temperature MR data well.Our study emphasizes the importance of considering the variation of m*in the analysis of quantum oscillations and Kohler's rule,and provides a method for extracting the temperature and magnetic field dependence of m*through quantum oscillations,which is very beneficial for the data analysis of other materials in the future.展开更多
Objective:To evaluate the clinical efficacy of albendazole in pediatric toxocariasis.Methods:This interventional study was conducted over a 6-month period,enrolling 117 children aged 3-15 years between 2023 and 2024 i...Objective:To evaluate the clinical efficacy of albendazole in pediatric toxocariasis.Methods:This interventional study was conducted over a 6-month period,enrolling 117 children aged 3-15 years between 2023 and 2024 in Ho Chi Minh City,Vietnam.All patients received oral albendazole at a dosage of 15 mg/kg/day,divided into two daily doses,for five consecutive days.Treatment efficacy was assessed at 6 months based on the following criteria:(1)resolution or marked improvement of clinical symptoms;(2)negative ELISA serology;(3)normalization or significant reduction of eosinophil(EOS)counts to within the normal range;and(4)normalization or significant reduction of total IgE levels.Results:After six months,significant reductions were observed in white blood cell(WBC)count,neutrophil(NEU)count,mean corpuscular hemoglobin(MCH),mean corpuscular volume(MCV),mean corpuscular hemoglobin concentration(MCHC),platelet(PLT)count,EOS count,ELISA optical density(OD),aspartate aminotransferase(AST),alanine aminotransferase(ALT),and creatinine levels(all P<0.05).Age-stratified analysis revealed that children aged 3-11 years showed statistically significant improvements in OD levels and EOS counts compared to baseline(P<0.05).The overall treatment recovery rate was 28%.Conclusions:The cure rate for pediatric toxocariasis following a five-day albendazole regimen remains modest.Further research is required to optimize treatment durations and regimens to improve clinical outcomes in children.展开更多
The effective stress of marine sediments frequently shifts owing to natural or anthropogenic factors,and a broad spectrum of processes fundamentally require accounting for sediment responses to such changes.Marine sed...The effective stress of marine sediments frequently shifts owing to natural or anthropogenic factors,and a broad spectrum of processes fundamentally require accounting for sediment responses to such changes.Marine sediments hosting natural gas hydrates have been regarded as a prospective energy reservoir,and depressurization-driven production efficiency hinges largely on the effective absolute permeability of hydrate-bearing strata.Yet,how this permeability evolves during depressurization remains unresolved,and whether pore-hosted hydrates impede or enhance it remains ambiguous.This study probes the permeability response of hydrate-bearing sands to cyclic loading through isotropic compression/swelling and water flow tests.Results reveal that methane hydrate presence curbs the void-ratio decline yet amplifies the effective-void-ratio reduction during isotropic loading.The effective absolute permeability of hydrate-bearing sands declines with rising hydrate saturation and increasing mean effective stress,and permeability stress sensitivity intensifies at higher hydrate saturations and lower mean effective stresses.The introduced model accurately predicts void-ratio changes during isotropic loading and unloading.Coefficients for strengthening,normal filling,and enhanced filling effects are introduced and quantified to disentangle the positive and negative influences of methane hydrate,with the negative filling effect exceeding the positive strengthening effect by one order of magnitude for quartz sands.展开更多
Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenv...Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.展开更多
The evaluation of air combat decision-making has garnered significant attention due to its potential to effectively mitigate losses resulting from erroneous decisions.However,existing research primarily focuses on sta...The evaluation of air combat decision-making has garnered significant attention due to its potential to effectively mitigate losses resulting from erroneous decisions.However,existing research primarily focuses on static evaluation methods.Therefore,this paper proposes a dynamic multi-round decision evaluation method based on the characteristics of multi-round unmanned aerial vehicle air combat under opponent’s optimal strategy.In order to determine objective weights,an improved multi-attribute decision making method is proposed,which incorporates the proximity as a correction coefficient for evaluation indicators,utilizing the cosine similarity instead of Euclidean distance,and incorporating both actual and theoretical objective weights to prevent data mutations.Subsequently,the game theory is employed to reasonably adjust subjective and objective weights to obtain comprehensive weights.To address the issues related to the ambiguity and randomness during the evaluation process,a reverse cloud generator is utilized to determine the center of gravity of the cloud model using comprehensive weights while employing the weighted deviation degree for evaluating air combat decision-making effectiveness.By activating the cloud generator through the cloud model,the optimal strategies for each round of air combat are determined,thereby completing the dynamic evaluations for multi-round sequential decision-making processes.Finally,the feasibility and effectiveness of the proposed method are verified through simulations.展开更多
BACKGROUND Real-world data remain limited on the effectiveness of magnesium isoglycyrrhizinate(MgIG)for post hepatectomy liver injury.We hypothesize that perioperative MgIG is effective as a management strategy agains...BACKGROUND Real-world data remain limited on the effectiveness of magnesium isoglycyrrhizinate(MgIG)for post hepatectomy liver injury.We hypothesize that perioperative MgIG is effective as a management strategy against hepatic injury in patients undergoing hepatectomy.AIM To evaluate the prophylactic and therapeutic effectiveness of MgIG for hepatic injury in patients undergoing hepatectomy in a real-world setting.METHODS We retrospectively reviewed the clinical data of consecutive Chinese patients who underwent hepatectomy between March 2020 and March 2023 at two tertiary care hospitals in China.The cohorts were balanced using propensity score matching(PSM).The primary outcome was the prevalence of postoperative liver injury,defined as≥3×upper limit of normal of the serum levels of alanine aminotransferase(ALT)or aspartate aminotransferase.RESULTS The rate of postoperative liver injury was 76.9%among 1711 eligible patients.After PSM,patients who received perioperative MgIG had a significantly greater reduction in the prevalence of liver injuries than those who only received postoperative MgIG on postoperative day(POD)3(53.3%vs 69.1%;P=0.006)and POD 7(14.2%vs 23.6%;P=0.027).The proportions of patients with≥50%reduction in ALT were significantly higher in patients treated with MgIG plus other liver protectants than those treated with other liver protectants on POD 3 and 7,and upon hospital discharge.Multivariable analysis indicated an independent protective role of prophylactic MgIG in postoperative liver injury.CONCLUSION This study indicates that the addition of preoperative prophylaxis to postoperative treatment with MgIG can mitigate of the rise of aminotransferases and enhance postoperative liver function recovery,conferring benefits on more surgical patients.展开更多
Asymmetric dual-atom site catalysts(ADASCs)inherit the high atomic utilization of single-atom site catalysts and synergistic effects of symmetric dual-atom site catalysts,while uniquely integrating the asymmetry of he...Asymmetric dual-atom site catalysts(ADASCs)inherit the high atomic utilization of single-atom site catalysts and synergistic effects of symmetric dual-atom site catalysts,while uniquely integrating the asymmetry of heteronuclear metal centers and asymmetric coordination environments.This structural merit endows them with tunable electronic configurations and optimized reaction kinetics,breaking conventional catalysts'inherent limitations to boost catalytic performance significantly.Despite existing reviews on dual-atom site catalysts for electrocatalysis,a comprehensive asymmetry-focused framework to elucidate ADASCs'catalytic behaviors remains elusive.This review summarizes the multi-dimensional regulation mechanisms of ADASCs.Structurally,heteronuclear metal synergy and bridging ligand co-anchoring suppress single-atom agglomeration.Electronically,d-band center modulation,spin coupling,and orbital hybridization optimize intermediate adsorption energies.Subsequently,the strategies for constructing asymmetric structures are elaborated,including the design of heteronuclear metal centers and the regulation of asymmetric coordination environments via nonmetallic atom engineering.Furthermore,the prominent advantages of ADASCs in oxygen electrocatalysis are highlighted as their asymmetric configurations can break the linear scaling relationship of intermediate adsorption,and optimize the reaction pathway as well as the adsorption behaviors of key intermediates.Finally,the current challenges and opportunities of ADASCs are discussed,providing valuable insights for the development of high-performance energy conversion devices.展开更多
The permeability of methane hydrate-bearing sediments(MHBS)is a key parameter for evaluating reservoir exploitation potential and formulating efficient production strategies.In actual field development,MHBS exists in ...The permeability of methane hydrate-bearing sediments(MHBS)is a key parameter for evaluating reservoir exploitation potential and formulating efficient production strategies.In actual field development,MHBS exists in a complex environment characterized by stress-seepage coupling.Research on the permeability model of methane hydrate-bearing sediments under multi-factor coupling conditions remains scarce,limiting the assessment of methane hydrate(MH)reservoir hydrocarbon production potential and efficient development.This study used quartz sand and deep-sea clay from the South China Sea as matrix materials to generate MH,simulating MHBS.Systematic triaxial seepage experiments were conducted to assess the influence of multiple factors,including triaxial shear process,effective confining pressure,and hydrate saturation,on the permeability characteristics of MHBS.The results demonstrate the following:(1)During triaxial compression,permeability exhibits a nonlinear variation—first decreasing and then stabilizing or rebounding—with increasing shear strain,reflecting stress-induced pore structure evolution;(2)the permeability of MHBS decreases nonlinearly with increasing effective confining pressure,showing higher sensitivity in the low-pressure range.Effective confining pressure reduces sample permeability by compressing seepage channels,and this effect is more significant at the initial stages of stress growth;(3)hydrate saturation is negatively correlated with permeability,with the cementing effect of hydrates being the primary cause for the decrease in permeability of MHBS,also reducing the impact of effective confining pressure;(4)effective confining pressure,hydrate saturation,and shear strain have a coupled effect,jointly influencing the permeability of MHBS,but their relative weights vary and require specific consideration;(5)based on experimental data,a permeability prediction model considering the coupling effects of shear strain,effective confining pressure,and hydrate saturation was established.This model demonstrates excellent predictive accuracy and can be applied to forecast the hydrocarbon yield potential of MHBS under varying geological and engineering conditions,providing quantitative basis for reservoir evaluation and gas production prediction.This study bridges the gap between laboratory permeability characterization and field production capacity forecasting,offering critical theoretical and technical support for the sustainable development of marine gas hydrate resources.展开更多
This study evaluated the cost‑effectiveness of bevifibatide versus eptifibatide for acute coronary syndrome(ACS)patients undergoing percutaneous coronary intervention(PCI)in China.A 30‑day decision tree and 15‑year Ma...This study evaluated the cost‑effectiveness of bevifibatide versus eptifibatide for acute coronary syndrome(ACS)patients undergoing percutaneous coronary intervention(PCI)in China.A 30‑day decision tree and 15‑year Markov model simulated outcomes using matching‑adjusted indirect comparison data.Base‑case analysis used the current listed price of bevifibatide(¥1290/vial).Costs and quality‑adjusted life‑years(QALYs)were evaluated against willingness‑to‑pay(WTP)thresholds based on China's per capita gross domestic product(GDP).Base‑case results showed bevifibatide added¥12,909.24 and 0.0595 QALYs,yielding an incremental cost‑effectiveness ratio(ICER)of¥216,899/QALY.This significantly exceeds the¥76,599 WTP threshold(0.8 times GDP),indicating it is not cost‑effective.Lifetime analysis confirmed these results(ICER:¥159,541/QALY).Threshold analysis indicated a price reduction to approximately¥595/vial is required to achieve cost‑effectiveness.In conclusion,bevifibatide is not cost‑effective for ACS patients undergoing PCI in China at its current price.A substantial price reduction is necessary to align cost with clinical value,providing an evidence‑based threshold for future reimbursement negotiations.展开更多
基金jointly funded by the Laoshan Laboratory Self-Initiated Scientific and Technological Innovation Project(No.LSKJ202204803)the Major Science and Technology Project of China National Offshore Oil Corporation(CNOOC)during the‘14th Five-Year Plan’(No.KJGG2022-0104)+1 种基金the National Natural Science Foundation of China(Nos.42074138,42206195)the Research on Noise Attenuation and Imaging Processing of Shallow Profile Data(No.2022DY03)。
摘要Deep tight sandstone reservoirs,which are characterized by complex features including compaction,consolidation,superposition of multi-stage channel sand bodies,and differential sedimentary infill,usually present different pore-permeability characteristics and evident heterogeneity.Tight sandstone reservoirs exhibiting low to ultra-low permeability can be categorized into various types of effective reservoirs according to porosity and permeability parameters as key assessment indicators.Therefore,within the macro background of low permeability,the development areas presenting relatively high porosity and permeability(sweet spots)are the primary targets for investigation.However,distinguishing these types of effective reservoirs remains difficult due to the inadequate discriminative power of single elastic parameters,which introduces challenges for direct pre-stack seismic prediction.To address this concern,we propose a method for defining effective reservoir indicators by integrating reservoir physical parameters and establishing a statistical rock physical relationship between the indicators and elastic impedance.This technique constructs a seismic prediction framework for multiple types of effective reservoirs in deep tight sandstones on the basis of the Bayesian probabilistic inversion strategy.Results from model testing and field data applications validate the strong potential of the method for exploration practice.
基金supported by grants from the National Natural Science Foundation of China(Nos.W2411019 and 32373115)the Blue Seed Industry Innovation Project of Qingdao Institute of Blue Seed Industry(No.QDLYY-2024001)the Taishan Industrial Experts Program,and the Laoshan Laboratory。
摘要To calculate the biological zero and the effective accumulated temperature(EAT)for gonadal development in one-and two-year-old diploid and tetraploid Pacific oysters(Crassostrea gigas),four indoor heating experiments were carried out in2022-2024.The biological zeros of diploids and tetraploids were 7.84℃and 7.45℃,respectively.The EAT in diploids was lower than that in tetraploids,at 389.05℃×d and 546.95℃×d,respectively.Histological analysis indicated that gonadal development was more rapid in diploids than in tetraploids.Simultaneously,one-and two-year-old diploid and tetraploid oysters had the same EAT.The proportion of females dominated all four study groups,especially the tetraploids.Age and ploidy did not significantly influence the cumulative survival rate(CSR).Gonadal development and warm temperatures may be the primary causes of mortality.The incremental survival rate(ISR)during the first half of the entire experimental cycle(ISR1)was markedly higher than that of the second half(ISR2)in both the diploid and tetraploid groups.These results suggest that one-and two-year-old tetraploid oysters could be used for the large-scale production of triploids by providing indoor heating.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3701000,Task 4)the National Natural Science Foundation of China(Grant Nos.42207126 and 41877314)。
摘要The effective density(ρeff)is a key parameter of black carbon-containing(BCc)particles and is related to their morphologies,deposition processes,and optical properties.In this study,a tandem system was established and used to determine theρeffof ambient BCc particles.The results showed that theρeffdistribution of ambient BCc particles exhibited a bimodal pattern with a left peak located at 0.69 g cm-3and a right peak at 1.45 g cm-3.The averageρeffof BCc particles over the entire observation period was 1.38 g cm-3.Theρeffof BCc particles showed a clear diurnal pattern with a relatively stable distribution at night and large variations during the daytime.Theρeffvalue was demonstrated to be a good indicator of BCc particle morphology.BCc particles became more regular with increasingρeffrelated to the increasing coating thickness.More coating led to morphological restructuring of BCc particles.The restructuring could be more efficient under high relative humidity conditions.The observed data were further used in a dry deposition scheme,and it was found that the dry deposition velocity of fresh emitted BCc could be largely influenced by its irregular shape.This study reveals the presence of a significant amount of low-density/irregularly shaped black carbon in the environment with rapid morphological changes occurring during the daytime and highlights the need to consider morphological influences in future research on the physicochemical properties of BCc.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
摘要AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
基金funded by the National Natural Science Foundation of China(NSFC)under Grant Number 72071209.
摘要Modern battlefields exhibit high dynamism,where traditional static weighting methods in combat effectiveness assessment fail to capture real-time changes in indicator values,leading to limited assessment accuracy—especially critical in scenarios like sudden electronic warfare or degraded command,where static weights cannot reflect the operational value decay or surge of key indicators.To address this issue,this study proposes a dynamic adaptive weightingmethod for evaluation indicators based onG1-CRITIC-PIVW.First,theG1(Sequential Relationship Analysis Method)subjective weighting method—translates expert knowledge into indicator importance rankings—leverages expert knowledge to quantify the relative importance of indicators via sequential relationship ranking,while the CRITIC(Criteria Importance Through Intercriteria Correlation)objective weighting method—derives weights from data characteristics by integrating variability and inter-correlations—calculates weights by integrating indicator variability and inter-indicator correlations,ensuring data-driven objectivity.These two sets of weights are then fused using a deviation coefficient optimization model,minimizing the squared deviation from a reference weight and adjusting the fusion coefficient via Spearman’s rank correlation to resolve potential conflicts between subjective and objective judgments.Subsequently,the PIVW(Punishment-Incentive VariableWeight)theory—adapts weights to realtime indicator performance via penalty/incentive rules—is applied for dynamic adjustment.Scenario-specific penalty λ1 and incentive λ2 thresholds are set based on operational priorities and indicator volatility,penalizing indicators with values below λ1 and incentivizing those exceeding λ2 to reflect real-time indicator performance.Experimental validation was conducted using an Air Defense and Anti-Missile(ADAM)system effectiveness assessment framework,with data covering 7 indicators across 3 combat scenarios.Results show that compared to static weighting methods,the proposed method reduces MAE(Mean Absolute Error)by 15%-20% and weighted decision error rate by 84.2%,effectively reducing overestimation/underestimation of combat effectiveness in dynamic scenarios;compared to Entropy-TOPSIS,it lowers MAE by 12% while achieving a weighted Kendall’sτconsistency coefficient of 0.85,ensuring higher alignment with expert judgment.This method enhances the accuracy and scenario adaptability of effectiveness assessment,providing reliable decision support for dynamic battlefield environments.
基金supported by Research Program of the Tianjin Natural Science Foundation Project(Grant No.25JCQNJC00540,25JCYBJC00590)。
摘要The eff ective elastic thickness(Te)of the lithosphere serves as a critical parameter for characterizing the mechanical strength and structural response of the lithosphere.In this study,Te and the initial load ratio(F)were jointly estimated for the North China Craton and its surrounding regions using a combined admittance–coherence inversion approach within a Bayesian framework,incorporating Markov Chain Monte Carlo(MCMC)sampling to quantify parameter uncertainties.The results reveal signifi cant lateral variations in Te across the study area,ranging from 5 to 66 km.High Te values(30–66 km)are observed beneath the Ordos Block,indicating a stable and mechanically strong lithosphere.In contrast,the North China Block exhibits low Te values(5–25 km),suggesting lithospheric thinning and mechanical weakening.These fi ndings are further supported by seismicity patterns,lithosphere–asthenosphere boundary(LAB)depth,and mantle composition(Mg#),all of which demonstrate a strong correlation between Te and lithospheric structure and dynamic processes.Low-Te regions are associated with high seismic activity and a“thin–hot–weak”lithospheric signature,whereas high-Te regions exhibit a“thick–cold–strong”stable configuration.It is proposed that the destruction of the North China Craton has been primarily driven by asthenospheric thermal perturbation,following a geodynamic evolution involving“thermal disturbance–lithospheric thinning–compositional modification–mechanical weakening.”This study provides new mechanical constraints on the geodynamic processes responsible for craton destruction.
基金supported by State Key Laboratory of Offshore Natural Gas Hydrates Open Fund Project(KJQZ-2024-2102)。
摘要The process of exploiting natural gas hydrates involves complex phase changes,multiphase seepage,and intricate heat transfer processes.A comprehensive understanding of the heat transfer characteristics in natural gas hydrate reservoirs is crucial for enhancing their exploitation efficiency.However,at present,there is a limited amount of research on the effective thermal conductivity(ETC)of complex component systems in marine natural gas hydrate reservoirs,which directly restricts the optimization of natural gas hydrate exploitation technologies in marine sediments.This study proposes a method to predict the ETC of marine natural gas hydrate reservoirs based on machine learning(ML).This method constructed an ETC dataset under the conditions including reservoir environmental characteristics(temperature,pressure,salt concentration),reservoir physical property characteristics(quartz sand content,montmorillonite content,illite content),and reservoir structural characteristics(initial water saturation,hydrate saturation,component phase).In this work,a dataset containing 200 data points from various literature was compiled.Six ML models were employed to predict the ETC of the reservoirs based on this dataset with a high-precision ETC prediction model being derived through ML training.The SHapley Additive ex Planations(SHAP)method was subsequently applied to conduct interpretability analysis on the model prediction results.This has not only confirmed the model's reliability but also quantitatively highlighted the sensitivity of key reservoir characteristics to ETC.The research results show that the Gradient Boosting Decision Tree(GBDT)model is particularly effective for predicting the ETC of marine natural gas hydrate reservoirs,as evidenced by its coefficient of determination(R2)exceeding 0.95.Sensitivity analysis reveals that the reservoir's salt concentration and illite content are the primary determinants of its overall ETC.The prediction method established in this study can provide effective technical support for the real-time evaluation of reservoir ETC during the on-site exploitation of marine natural gas hydrate reservoirs.
基金Supported by the National Natural Science Foundation of China(No.42006198)the National Key Research and Development Program of China(No.2022YFC2808302)the Taishan Scholarship from Shandong Province(No.tstp20230643)。
摘要A Moho topography admittance method with high-precision Moho depth inversion for calculating the effective elastic thickness(Te)of the oceanic lithosphere was established by comprehensively considering the effects of surface and subsurface loading.The accuracy of the method was verified through model testing and applied to the Northeast Pacific region.Te values in the study area range from 5 to 60 km,showing distinct spatial variations:regions with fracture zones such as Sedna,Surveyor,and Mendocino exhibit Te values generally<20 km.In thermally anomalous regions,the predictive capability of the standard thermal cooling model is significantly limited.Mantle plume-induced thermal anomalies disrupt the expected correlation between current heat flow and lithospheric age,resulting in a minimal correlation between Te and contemporary heat flow measurements.Earthquake distribution analysis shows that seismic events(M≥4)in the study area are concentrated within a Te of 10-60 km,of which 20% occur at Te values of 25-30 km.The Te-loading-age relationship along the Hawaii-Emperor Seamount Chain shows partial consistency with the standard thermal cooling model:in the Hawaii Ridge region,a synchronous decrease of Te with loading age;in the Emperor Seamount region,Te decreases from 47 to 10 km as the loading age decreases from 90 to 30 Ma,with a considerably lower slope than that of the Hawaii Ridge.However,the central seamounts exhibit an anomalous increase in Te(1-22 km),significantly deviating from the standard model.This study reveals that Te values cannot be predicted solely based on loading age,but are jointly influenced by multiple physical mechanisms including regional tectonic history,thermotectonic age,and crust-mantle decoupling induced by mantle plume thermal anomalies.In thermally anomalous regions,the applicability of the standard thermal cooling model is significantly limited,and predictions of lithospheric strength require region-specific corrections based on the regional tectonic background.
基金supported by National Nature Science Foundation of China(Grant No.42276178)。
摘要A primitive problem of predicting effective properties of composites is open boundary conditions.In this paper,Eshelby's transformation field method(TFM)is developed to solve the open boundary problem of two-phase composites having an arbitrary geometry of inclusion.The inhomogenous transformation fields are introduced in the composite system to cope with the complex interface boundary-value problem.Furthermore,the open boundary problem is solved by a Hermite polynomial,which is used to express the transformation fields and the perturbation fields.As an example,the formulas of calculating effective dielectric property of two-dimensional isotropic dielectric composites having open boundary conditions are derived by TFM.The validity is verified by comparing the effective responses estimated by TFM with the exact solutions of the dilute limit,and good agreements are obtained.The results show that TFM is valid to solve the open boundary problem of composites having complex geometric inclusions.
摘要Offshore thin interbedded reservoirs are characterized by frequent alternation of sandstone and mudstone,strong vertical heterogeneity,and complex fracture cross-layer propagation mechanisms,which constitute a key challenge constraining efficient hydraulic fracturing stimulation.This study investigates a typical thin interbedded sandstone reservoir,quantitatively classifying the reservoir into three representative models based on adjacent layer thickness ratio:homogeneous-dominated,sand-dominated,and mudstone-dominated types.Using the Planar Three-Dimensional(PL3D)fracture propagation model,235 simulation scenarios were systematically analyzed to reveal the controlling effects of interlayer stress difference and pumping rate on fracture cross-layer propagation capability.Results indicate that interlayer stress difference is the dominant controlling factor for fracture cross-layer propagation,with 8 MPa identified as the critical threshold for thin interbedded cross-layer propagation.When the stress contrast exceeds this value,fractures transition from three-dimensional penetration to single-layer horizontal propagation.Increasing pumping rate primarily drives horizontal fracture extension,constrained by the diminishing marginal effect of net pressure,and an optimal pumping rate range exists for fracture conductivity.Under high stress contrast conditions,simply increasing pumping rate cannot overcome the stress barrier.A quantitative mapping relationship between thin interbedded reservoir models and fracture geometries was systematically established,where fracture geometry evolution controls the spatial distribution characteristics of conductivity and constrains long-term productivity.A multi-dimensional evaluation chart integrating vertical fracture connectivity and stimulated reservoir area efficiency was constructed,delineating the quantitative boundaries of fracture cross-layer propagation capability under different geological and engineering conditions.Long-term development simulation demonstrates that three-dimensional cross-layer stimulation increases cumulative oil production by 2.7 times compared to single-layer stimulation.The research findings provide a theoretical basis and technical support for hydraulic fracturing parameter optimization and three-dimensional stimulation design in offshore thin interbedded reservoirs.
基金supported by the Natural Science Foundation of Ningxia Hui Autonomous Region(Nos.2026AAC030921 and 2025AAC030158)。
摘要Multiferroic composites hold great promise in electronic devices because of their exceptional magnetoelectric coupling effects,and multilayer core-shell nanofibers are considered as ideal carriers for achieving high-performance responses.However,existing theories often assume perfectly circular fiber cross-sections while neglecting the interfacial effects.This makes it difficult to accurately characterize the elliptical cross-sections and nanoscale interface properties commonly observed in practical fabrication.To address this issue,this study establishes a theoretical model for multilayer multiferroic nanofiber composites.The model simultaneously accounts for both the fiber shape and interfacial effects.Using the generalized self-consistency method and complex function approach,this work further derives analytical solutions for the effective magneto-electric-elastic(MEE)moduli.Based on this model,the study systematically investigates the influence of the coated fiber shape,fiber size,coated fiber volume fraction,and inner-to-outer coating thickness ratio on the composite's effective MEE moduli.The findings reveal the synergistic mechanism,by which the elliptical fiber shape and multiple interfacial effects regulate the magnetoelectric anisotropy,thereby providing crucial theoretical guidance for designing the structure of high-performance multiferroic nanocomposites and optimizing their performance.
基金supported by the National Key R&D Program of China(Grant Nos.2023YFA1406500,2024YFA1409002,and 2021YFA1400300)the National Natural Science Foundation of China(Grant Nos.12474098,12574042,12274388,12404043,12074425,and 12204004)+4 种基金the Natural Science Foundation of Anhui Province(Grant No.2408085QA024)the Science and Technology Projects in Guangzhou(Grant No.2023A04J1936)the Fundamental Research Funds for the Central Universities(Peking University)the Research Funds of Renmin University of China(Grant No.23XNKJ22)the Beijing National Laboratory for Condensed Matter Physics(Grant No.2023BNLCMPKF008)。
摘要The variation of the effective mass m*of carrier is often overlooked in experimental studies on quantum oscillations and Kohler's rule.Here,we report the magnetotransport properties of La3Sc Bi5and reveal the changing m*in it.The temperature and magnetic field dependence of m*follows the power-law scaling behavior at low temperature and leads to the failure of conventional analysis,which should not be ignored.In the analysis of the thermal factor and Dingle plot of de Haas-van Alphen oscillation in La3ScBi5,satisfactory fitting results can be obtained after considering the correction of m*.We have also applied this method to Sr1-yMn1-zSb2,solving the remaining fitting problem in previous reports.Moreover,the magnetoresistance(MR)of La3ScBi5has been found to violate Kohler's rule.Although the extended Kohler's rule is applicable to high-temperature MR data,it does not scale the low-temperature data well.We further modified the extended Kohler's rule by introducing m*,and subsequently scaled the low-temperature MR data well.Our study emphasizes the importance of considering the variation of m*in the analysis of quantum oscillations and Kohler's rule,and provides a method for extracting the temperature and magnetic field dependence of m*through quantum oscillations,which is very beneficial for the data analysis of other materials in the future.
摘要Objective:To evaluate the clinical efficacy of albendazole in pediatric toxocariasis.Methods:This interventional study was conducted over a 6-month period,enrolling 117 children aged 3-15 years between 2023 and 2024 in Ho Chi Minh City,Vietnam.All patients received oral albendazole at a dosage of 15 mg/kg/day,divided into two daily doses,for five consecutive days.Treatment efficacy was assessed at 6 months based on the following criteria:(1)resolution or marked improvement of clinical symptoms;(2)negative ELISA serology;(3)normalization or significant reduction of eosinophil(EOS)counts to within the normal range;and(4)normalization or significant reduction of total IgE levels.Results:After six months,significant reductions were observed in white blood cell(WBC)count,neutrophil(NEU)count,mean corpuscular hemoglobin(MCH),mean corpuscular volume(MCV),mean corpuscular hemoglobin concentration(MCHC),platelet(PLT)count,EOS count,ELISA optical density(OD),aspartate aminotransferase(AST),alanine aminotransferase(ALT),and creatinine levels(all P<0.05).Age-stratified analysis revealed that children aged 3-11 years showed statistically significant improvements in OD levels and EOS counts compared to baseline(P<0.05).The overall treatment recovery rate was 28%.Conclusions:The cure rate for pediatric toxocariasis following a five-day albendazole regimen remains modest.Further research is required to optimize treatment durations and regimens to improve clinical outcomes in children.
基金jointly supported by the National Natural Science Foundation of China(Grant 42025702)the Natural Science Foundation of Shandong Province(Grant ZR2022YQ54)the Taishan Scholars Program(No.tsqn202306297)。
摘要The effective stress of marine sediments frequently shifts owing to natural or anthropogenic factors,and a broad spectrum of processes fundamentally require accounting for sediment responses to such changes.Marine sediments hosting natural gas hydrates have been regarded as a prospective energy reservoir,and depressurization-driven production efficiency hinges largely on the effective absolute permeability of hydrate-bearing strata.Yet,how this permeability evolves during depressurization remains unresolved,and whether pore-hosted hydrates impede or enhance it remains ambiguous.This study probes the permeability response of hydrate-bearing sands to cyclic loading through isotropic compression/swelling and water flow tests.Results reveal that methane hydrate presence curbs the void-ratio decline yet amplifies the effective-void-ratio reduction during isotropic loading.The effective absolute permeability of hydrate-bearing sands declines with rising hydrate saturation and increasing mean effective stress,and permeability stress sensitivity intensifies at higher hydrate saturations and lower mean effective stresses.The introduced model accurately predicts void-ratio changes during isotropic loading and unloading.Coefficients for strengthening,normal filling,and enhanced filling effects are introduced and quantified to disentangle the positive and negative influences of methane hydrate,with the negative filling effect exceeding the positive strengthening effect by one order of magnitude for quartz sands.
摘要Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.
基金supported by the Major Projects for Science and Technology Innovation 2030(2018AAA0100805)National Natural Science Foundation of China(62373187).
摘要The evaluation of air combat decision-making has garnered significant attention due to its potential to effectively mitigate losses resulting from erroneous decisions.However,existing research primarily focuses on static evaluation methods.Therefore,this paper proposes a dynamic multi-round decision evaluation method based on the characteristics of multi-round unmanned aerial vehicle air combat under opponent’s optimal strategy.In order to determine objective weights,an improved multi-attribute decision making method is proposed,which incorporates the proximity as a correction coefficient for evaluation indicators,utilizing the cosine similarity instead of Euclidean distance,and incorporating both actual and theoretical objective weights to prevent data mutations.Subsequently,the game theory is employed to reasonably adjust subjective and objective weights to obtain comprehensive weights.To address the issues related to the ambiguity and randomness during the evaluation process,a reverse cloud generator is utilized to determine the center of gravity of the cloud model using comprehensive weights while employing the weighted deviation degree for evaluating air combat decision-making effectiveness.By activating the cloud generator through the cloud model,the optimal strategies for each round of air combat are determined,thereby completing the dynamic evaluations for multi-round sequential decision-making processes.Finally,the feasibility and effectiveness of the proposed method are verified through simulations.
基金Supported by the National Natural Science Foundation of China,No.82573407Basic and Applied Basic Research Foundation of Guangdong Province,No.2023A1515220211the Furong Plan Health High Level Talent Project of Hunan Province,No.20250924-1015.
摘要BACKGROUND Real-world data remain limited on the effectiveness of magnesium isoglycyrrhizinate(MgIG)for post hepatectomy liver injury.We hypothesize that perioperative MgIG is effective as a management strategy against hepatic injury in patients undergoing hepatectomy.AIM To evaluate the prophylactic and therapeutic effectiveness of MgIG for hepatic injury in patients undergoing hepatectomy in a real-world setting.METHODS We retrospectively reviewed the clinical data of consecutive Chinese patients who underwent hepatectomy between March 2020 and March 2023 at two tertiary care hospitals in China.The cohorts were balanced using propensity score matching(PSM).The primary outcome was the prevalence of postoperative liver injury,defined as≥3×upper limit of normal of the serum levels of alanine aminotransferase(ALT)or aspartate aminotransferase.RESULTS The rate of postoperative liver injury was 76.9%among 1711 eligible patients.After PSM,patients who received perioperative MgIG had a significantly greater reduction in the prevalence of liver injuries than those who only received postoperative MgIG on postoperative day(POD)3(53.3%vs 69.1%;P=0.006)and POD 7(14.2%vs 23.6%;P=0.027).The proportions of patients with≥50%reduction in ALT were significantly higher in patients treated with MgIG plus other liver protectants than those treated with other liver protectants on POD 3 and 7,and upon hospital discharge.Multivariable analysis indicated an independent protective role of prophylactic MgIG in postoperative liver injury.CONCLUSION This study indicates that the addition of preoperative prophylaxis to postoperative treatment with MgIG can mitigate of the rise of aminotransferases and enhance postoperative liver function recovery,conferring benefits on more surgical patients.
基金supported by the National Natural Science Foundation of China(62273134)the Program for Science&Technology Innovative Research Team in the University of Henan Province(25IRTSTHN005)+5 种基金the Key R&D Special Project of Henan Province(241111322400)the Postdoctoral Fellowship Program of CPSF(GZB20250043)the China Postdoctoral Science Foundation(2025M770169)the Key Science and Technology Program of Henan Province(252102230077)the Fundamental Research Funds for the Universities of Henan Province(NSFRF2502050)the Key Research Projects of Higher Education Institutions in Henan Province(25A150004)。
摘要Asymmetric dual-atom site catalysts(ADASCs)inherit the high atomic utilization of single-atom site catalysts and synergistic effects of symmetric dual-atom site catalysts,while uniquely integrating the asymmetry of heteronuclear metal centers and asymmetric coordination environments.This structural merit endows them with tunable electronic configurations and optimized reaction kinetics,breaking conventional catalysts'inherent limitations to boost catalytic performance significantly.Despite existing reviews on dual-atom site catalysts for electrocatalysis,a comprehensive asymmetry-focused framework to elucidate ADASCs'catalytic behaviors remains elusive.This review summarizes the multi-dimensional regulation mechanisms of ADASCs.Structurally,heteronuclear metal synergy and bridging ligand co-anchoring suppress single-atom agglomeration.Electronically,d-band center modulation,spin coupling,and orbital hybridization optimize intermediate adsorption energies.Subsequently,the strategies for constructing asymmetric structures are elaborated,including the design of heteronuclear metal centers and the regulation of asymmetric coordination environments via nonmetallic atom engineering.Furthermore,the prominent advantages of ADASCs in oxygen electrocatalysis are highlighted as their asymmetric configurations can break the linear scaling relationship of intermediate adsorption,and optimize the reaction pathway as well as the adsorption behaviors of key intermediates.Finally,the current challenges and opportunities of ADASCs are discussed,providing valuable insights for the development of high-performance energy conversion devices.
基金financially supported by Shenzhen Science and Technology Program(RCJC20210706091948015,KJZD20231025152759002)the support provided by the National Natural Science Fund Foundation of China(52374357,52225403)。
摘要The permeability of methane hydrate-bearing sediments(MHBS)is a key parameter for evaluating reservoir exploitation potential and formulating efficient production strategies.In actual field development,MHBS exists in a complex environment characterized by stress-seepage coupling.Research on the permeability model of methane hydrate-bearing sediments under multi-factor coupling conditions remains scarce,limiting the assessment of methane hydrate(MH)reservoir hydrocarbon production potential and efficient development.This study used quartz sand and deep-sea clay from the South China Sea as matrix materials to generate MH,simulating MHBS.Systematic triaxial seepage experiments were conducted to assess the influence of multiple factors,including triaxial shear process,effective confining pressure,and hydrate saturation,on the permeability characteristics of MHBS.The results demonstrate the following:(1)During triaxial compression,permeability exhibits a nonlinear variation—first decreasing and then stabilizing or rebounding—with increasing shear strain,reflecting stress-induced pore structure evolution;(2)the permeability of MHBS decreases nonlinearly with increasing effective confining pressure,showing higher sensitivity in the low-pressure range.Effective confining pressure reduces sample permeability by compressing seepage channels,and this effect is more significant at the initial stages of stress growth;(3)hydrate saturation is negatively correlated with permeability,with the cementing effect of hydrates being the primary cause for the decrease in permeability of MHBS,also reducing the impact of effective confining pressure;(4)effective confining pressure,hydrate saturation,and shear strain have a coupled effect,jointly influencing the permeability of MHBS,but their relative weights vary and require specific consideration;(5)based on experimental data,a permeability prediction model considering the coupling effects of shear strain,effective confining pressure,and hydrate saturation was established.This model demonstrates excellent predictive accuracy and can be applied to forecast the hydrocarbon yield potential of MHBS under varying geological and engineering conditions,providing quantitative basis for reservoir evaluation and gas production prediction.This study bridges the gap between laboratory permeability characterization and field production capacity forecasting,offering critical theoretical and technical support for the sustainable development of marine gas hydrate resources.
摘要This study evaluated the cost‑effectiveness of bevifibatide versus eptifibatide for acute coronary syndrome(ACS)patients undergoing percutaneous coronary intervention(PCI)in China.A 30‑day decision tree and 15‑year Markov model simulated outcomes using matching‑adjusted indirect comparison data.Base‑case analysis used the current listed price of bevifibatide(¥1290/vial).Costs and quality‑adjusted life‑years(QALYs)were evaluated against willingness‑to‑pay(WTP)thresholds based on China's per capita gross domestic product(GDP).Base‑case results showed bevifibatide added¥12,909.24 and 0.0595 QALYs,yielding an incremental cost‑effectiveness ratio(ICER)of¥216,899/QALY.This significantly exceeds the¥76,599 WTP threshold(0.8 times GDP),indicating it is not cost‑effective.Lifetime analysis confirmed these results(ICER:¥159,541/QALY).Threshold analysis indicated a price reduction to approximately¥595/vial is required to achieve cost‑effectiveness.In conclusion,bevifibatide is not cost‑effective for ACS patients undergoing PCI in China at its current price.A substantial price reduction is necessary to align cost with clinical value,providing an evidence‑based threshold for future reimbursement negotiations.