A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,conf...A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca3(PO4)2,and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.展开更多
Liver is the most common site of metastases of colorectal cancer,and liver metastases present with distinct histopathological growth patterns(HGPs),including desmoplastic,pushing and replacement HGPs and two rare HGPs...Liver is the most common site of metastases of colorectal cancer,and liver metastases present with distinct histopathological growth patterns(HGPs),including desmoplastic,pushing and replacement HGPs and two rare HGPs.HGP is a miniature of tumor-host reaction and reflects tumor biology and pathological features as well as host immune dynamics.Many studies have revealed the association of HGPs with carcinogenesis,angiogenesis,and clinical outcomes and indicates HGP functions as bond between microscopic characteristics and clinical implications.These findings make HGP a candidate marker in risk stratification and guiding treatment decision-making,and a target of imaging observation for patient screening.Of note,it is crucial to determine the underlying mechanism shaping HGP,for instance,immune infiltration and extracellular matrix remodeling in desmoplastic HGP,and aggressive characteristics and special vascularization in replacement HGP(rHGP).We highlight the importance of aggressive features,vascularization,host immune and organ structure in formation of HGP,hence propose a novel"advance under camouflage"hypothesis to explain the formation of rHGP.展开更多
With the rapid development of private higher education,the construction of counselor teams in private universities has become increasingly important.This paper focuses on outstanding counselors in private universities...With the rapid development of private higher education,the construction of counselor teams in private universities has become increasingly important.This paper focuses on outstanding counselors in private universities,delving into their growth patterns and proposing targeted training paths based on this analysis.By reviewing relevant theories and analyzing case studies of excellent counselors,it is found that outstanding counselors in private universities exhibit stage-specific characteristics during their development,influenced by personal traits,school environment,career progression,and other factors.In terms of training approaches,efforts should be made to improve selection mechanisms,strengthen training systems,provide career development support,and create a positive work atmosphere,all aimed at enhancing the overall quality of the counselor team in private universities and better serving student growth and institutional development.展开更多
Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.Methods:Forty-five patients with normal o...Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.Methods:Forty-five patients with normal occlusion(23 males,22 females) were included in this study.Among these patients,20 displayed the vertical growth pattern,and 20 had the horizontal growth pattern,while the remaining patients displayed the average growth pattern.All of the patients underwent dental cone beam computed tomography(CBCT),which included the region of the mandibular posterior teeth and the alveolar.A linear regression analysis and a correlation analysis between the facial height index(FHI) and the alveolar bone morphology were performed.Results:The inclination of the molars,the thickness of the cortical bone,and the height of the mandibular bone differed significantly between patients with the horizontal growth pattern and those with the vertical growth pattern(P<0.05).Significant positive correlations were found between:the FHI and the inclination of the molars;the FHI and the thickness of the cortical bone;and the FHI and the height of the mandibular bone.Conclusions:The mandibular posterior tooth-alveolar bone complex morphology may be affected by growth patterns.展开更多
The Baiyunpu deposit lies in the southwest plunging Dachengshan anticline in central Hunan, which is a large Pb-Zn polymetallic deposit. The orebodies were surrounded by the Qiziqiao Formation limestone in the Middle ...The Baiyunpu deposit lies in the southwest plunging Dachengshan anticline in central Hunan, which is a large Pb-Zn polymetallic deposit. The orebodies were surrounded by the Qiziqiao Formation limestone in the Middle Devonian, and its geological occurrence is consistent with the wall rocks. A large number of spheroidal pyrite aggregates are found unevenly distributed in the ores. The spheroidal aggregates are made up of kernels and concentric rings. The kernels are composed of approximately epigranular pyrite nanocrystals, while the rings are composed of accumulated pyrite microcrystals growing along the radial direction. The spheroidal pyrite aggregate and its outer zones can be divided into five areas(A–E). The results of electron probe micro analysis(EPMA) show that from the zone A1 to B, Co/Ni 〈1, the sum of Co and Ni is 0.08%–0.26%, S/Fe increases from 2.06 to 2.15. While from the zone C to E, Ni cannot be detected and S/Fe decreases from 2.22 to 2.08. Powder X-ray diffraction(XRD) analysis in the micro zone shows obvious crystalline characteristics in the aggregates. Moving from the inside outwards, the maximum diffraction peak intensity of the(111) and(220) crystal planes of pyrite increases, and the crystallinity improves. The degree of change in the(111) plane is the most prominent. Considering the theory of crystal growth along with the geologic features of the depositional environment where the spheroidal pyrite aggregates developed, we confirm that the spheroidal aggregates are the result of nano-micro crystalline gathering and growth occurring by the following sequence of processes:nano-crystalline nucleation and growth, gathering into a ball, oriented growth of microcrystals, continuous accumulation, and adjustment of grain boundaries. The formation of the spheroidal pyrite aggregates in the late Qiziqiao Formation of the Middle Devonian occurred in a neutral to weak alkaline and reductive sedimentary environment in the normal oxygen-rich shallowwater carbonate platform edge. The variations in the S/Fe ratio and crystallisation characteristics indicate that during pyrite crystal growth, the sulphur fugacity was high locally and rose constantly, the degree of supersaturation decreased locally and the growth environment was stable relatively.展开更多
A study on seasonal abundance,morphometric and meristic data,growth pattern,condition fector,sex ratio and gonadosomatic index of Liza falcip-innis(Wlenciennes,1836)from the Ojo axis of Badagry creek,Nigeria was condu...A study on seasonal abundance,morphometric and meristic data,growth pattern,condition fector,sex ratio and gonadosomatic index of Liza falcip-innis(Wlenciennes,1836)from the Ojo axis of Badagry creek,Nigeria was conducted from May 2019 to March 2020.A total of 1012 species were randomly selected,having 499 females and 513 males.The length frequency analysis and length-weight relationships(LWR)were determined.Sex ratio was determined by Chi-square analysis.The results showed that morphometric data are:0.5-2.5 mm for ED,2.1-12 mm for HL,1.7-8.1 mm for HD,2.5-11.7 for BD,2.6-233.3 mm for TL and 9.23-1006 g for BW for the combined sexes.The slope(b)shows an allometric growth pattern.The intercept'a'and slope'b'of the LWR(LogW=a+bLogL)were Log W=15.39+0.34 LogL(r=0.54)for combined sexes,Log W=12.49+0.02 log L(r=0.38)for males and Log W=18.23+0.01 log L(r=0.16)for females.The length frequency distribution indicated that species were dominated by two year classes(Ages 1 and 2).Condition factors were generally low.The values ranged between 0.68-0.85 for combined sexes.The gonadosomatic index for female was highest in August,2019(17.77%)with Mean±SD of 2.88±0.75;which indicated the peak of spawning period in the study area.Sex ratio difference was significant(P<0.05).Sexual differences were significant;the females are phenotypically larger than the male.展开更多
The clonal growth pattern of Sabina vulgaris, a coniferous clonal plant in Mu Us sandland, Inner Mongolia Autonomous Region was surveyed. The results showed that with the stolon extending, internode length and branchi...The clonal growth pattern of Sabina vulgaris, a coniferous clonal plant in Mu Us sandland, Inner Mongolia Autonomous Region was surveyed. The results showed that with the stolon extending, internode length and branching angle decreased, the branching intensity increased gradually within the 3 m range from the edge of the shrub to its center along the stolon. Internode length, branching intensity and branching angle were 5.9 cm, 4.4 and 55.3°in the shrub, and 1.6 cm, 13.7 and 38.3°at the edge of the shrub, respectively. The clonal architecture exhibited plasticity. The internode length, branching intensity and ramet length changed with an exponential model with extention of the stolon. The stolon of S. vulgaris was monopodial branching, and each ramet should possess more than 3 adventitious roots. Ramets could take on the phenomenon of 搒elf-thinning?with clonal growth. There was a prior grade in allocation of the nutrients gained from heterogeneous space. The clonal architecture of S. vulgaris was the 搈ixed?type.展开更多
Tree growth is affected by environmental factors, climate condition and tree age. The objective of this study was to evaluate the growth patterns of Chamaecyparis obtusa (C. obtusa) stand in the Gyeongnam province. Da...Tree growth is affected by environmental factors, climate condition and tree age. The objective of this study was to evaluate the growth patterns of Chamaecyparis obtusa (C. obtusa) stand in the Gyeongnam province. Data was collected from two cities and one county by using sample quadrats of 20 * 20 m. A total of 11 quadrats were used to collect tree height, diameter at the breast height (DBH), annual growth rings and soil data. The data analysis of soil moisture content, pH, organic matter (%), EC (cmol + /kg of soil), and available phosphorous was conducted. Growth ring was analyzed by using computer based software and the ages of the trees were identified. Average growth of height and DBH was computed from the surveyed data and annual growth of each tree was assessed by computer based reading of annual growth rings. The results of the study revealed that tree growth showed a reducing trend along the longevity. It was identified that soil pH, age, variation in annual average temperature, and altitude were the main factors related with growth of C. obtusa trees along the life of the stand.展开更多
The BRICS (Brazil, Russia, India, China and South Africa) and other emerging economies have become a driving global force for the past twenty years. However, their growth patterns are obsolete, impeding the quality ...The BRICS (Brazil, Russia, India, China and South Africa) and other emerging economies have become a driving global force for the past twenty years. However, their growth patterns are obsolete, impeding the quality and competitiveness of their economic growth, while simultaneously threatening the sustainability of their economic convergence with developed nations. Transforming the domestic growth pattern-the solution to the middle-income trap-has therefore become a key priority for each of these economies. This paper presents a comparative analysis of how to transform the pattern of economic growth in BRICS and achieve sustainable economic convergence with a comparative analysis of the pattern of economic growth and problems among BRICS countries.展开更多
Using Cobb-Douglas production function and Solow Residual, this study establishes a discriminant index to measure the intensive index of coal-production at the section-level, so as to analyze the transfer trend of the...Using Cobb-Douglas production function and Solow Residual, this study establishes a discriminant index to measure the intensive index of coal-production at the section-level, so as to analyze the transfer trend of the growth pattern of Jiangsu's coal-production since 1990s. The research shows that the transition of coal production in Jiangsu Province has mainly experienced three phases, which are the quick transition phase from extensive growth to intensive growth (from 1990 to 1994), the fluctuation phase (from 1995 to 1999), and the transition back phase from intensive growth to extensive growth (from 2000 to 2003). On the whole, the coal production in Jiangsu Province nowadays is still featured by extensive growth pattern and largely dependent upon capital inputs. Finally, from the aspect of the technology progress, improving the qualities of labor, changing product structures and improving enterprise management, this study puts forward suggestions on how to transfer the growth pattern of Jiangsu's coal-production into intensive type.展开更多
Over the past 20 years, China has made spectacular achievements in economic growth as well as in thetransformation of economic growth pattern. Industrial structure is being updated, and technology is playing a more an...Over the past 20 years, China has made spectacular achievements in economic growth as well as in thetransformation of economic growth pattern. Industrial structure is being updated, and technology is playing a more andmore important role in economic development. The energy and resource consumption in many industries and enterprisesare reducing. However, we should realize that there are still many problems in changing the economic growth pattern,such as high input, high consumption, high discharge, inharmony, recycling difficulty, and low efficiency, which havegreatly impaired and restrict Chinese economic development. Therefore, the fundamental change of the economic growthpattern is inevitable. Based on the analysis on the status quo and the exploit of resources, this paper suggests that thetransformation from unsustainable to sustainable growth is the only choice in changing the economic growth pattern. Inaddition, the transformation should not completely rely on the fundamental effects of market mechanism. We should makefull use of the power of governments to speed up the transformation of economic system.展开更多
Intra-annual climatic variability plays a critical role in regulating wood formation dynamics during the growing season,particularly in seasonally arid regions—such as the Qinling Mountains,China,and Mediterranean fo...Intra-annual climatic variability plays a critical role in regulating wood formation dynamics during the growing season,particularly in seasonally arid regions—such as the Qinling Mountains,China,and Mediterranean forests—where trees exhibit bimodal radial growth patterns as an adaptive response to water stress.While these growth patterns reflect immediate climatic conditions,the role of ecological memory,specifically vegetation growth carryover(VGC)and lagged climate effects(LCEs),remains poorly quantified.We employed the Vaganov–Shashkin(VS)model to analyze intra-annual bimodal growth patterns in two regions and used a vector autoregressive model with impulse response functions to assess the duration and intensity of VGC and LCE on tree-ring growth and remote sensing vegetation indices(leaf area index(LAI)and gross primary productivity(GPP)).Our results revealed bimodal growth patterns with spring and autumn peaks,but the autumn peak occurred earlier in the Qinling Mountains(August–October)than in Mediterranean forests(late September–October).VGC exerted the strongest influence on tree-ring growth in the first year,diminishing significantly after eight years in both regions(p<0.01).Tree-ring growth exhibited positive LCE responses to precipitation and soil moisture but negative responses to temperature(p<0.05).Remote sensing indices(LAI and GPP)displayed stronger VGC effects in the Qinling Mountains than in Mediterranean forests.While both LAI and GPP responded positively to soil moisture,temperature-induced LCE was positive in the Qinling Mountains but negative in the Mediterranean forests(p<0.05).Overall,VGC was the dominant ecological memory effect in both regions.Our results suggest that coupling the VGC and LCE of multiple vegetation growth indicators at multiple scales has the potential to improve the accuracy of global dynamic vegetation models.展开更多
Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and i...Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and increment deposition.In this study,the gladius growth patterns with somatic growth and gonad development were evaluated for two geographic stocks of the jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean.The microstructure and periodicity of the gladius growth increments were also investigated.Results showed varied correlations between four gladius morphometric characteristics with dorsal mantle length,while growth in body weight almost followed a power model.Sexual gladius growth patterns occurred with gonad development,possibly due to different biological functions of these gladius parts and sex-specific energetic allocations.Gladius increments were observed formation in the stem and lateral plate and could be consistently enumerated.The daily periodicity of increment deposition,at least over 144 days old,was validated by comparing gladius increments with the ages obtained from the statoliths.The different oceanographic conditions between two areas likely influence the gladius growth and increment deposition and promote higher increment counts in squid from equatorial waters.Above all,these results provided new information on gladius microstructures and growth increment in different stocks of D.gigas and confirmed the use of this tissue for size-specific growth and age determination.展开更多
Achieving dual goals of economic growth and carbon emission reduction is a major issue in China. In this paper we deifne three economic growth patterns (green growth, brown growth and black growth) according to the ...Achieving dual goals of economic growth and carbon emission reduction is a major issue in China. In this paper we deifne three economic growth patterns (green growth, brown growth and black growth) according to the relationship between economic scale and carbon emissions, and then trace the historical trajectory of economic growth over the last 40 years. Granger causality is used to test China’s economic growth and carbon emission linkage. We argue that green growth means that the rate of carbon emission reduction is faster than the increase in GDP. When carbon intensity reduction is slower than GDP growth, brown growth occurs. Black growth occurs when both carbon intensity and economic scale increase. For China, we denote the four periods of black growth (1971–1977), brown growth (1978–2001), black growth (2002–2004), and brown growth (2004–2010). Granger causality tests indicate that mutual causality between carbon emissions and economic growth exists in the short term, but not the long term. In order to achieve the goals of economic growth and carbon intensity reduction, it is necessary for China to actively participate in global carbon reduction activities, technological innovation and ecological civilization construction.展开更多
Despite the fast progress in our understanding of the complex functions of gut microbiota,it is still challenging to directly investigate the in vivo microbial activities and processes on an individual cell basis.To g...Despite the fast progress in our understanding of the complex functions of gut microbiota,it is still challenging to directly investigate the in vivo microbial activities and processes on an individual cell basis.To gain knowledge of the indigenous growth/division patterns of the diverse mouse gut bacteria with a relatively high throughput,here,we propose an integrative strategy,which combines the use of fluorescent probe labeling,confocal imaging with single‐cell sorting,and sequencing.Mouse gut bacteria sequentially labeled by two fluorescent D‐amino acid probes in vivo were first imaged by confocal microscopy to visualize their growth patterns,which can be unveiled by the distribution of the two fluorescence signals on each bacterium.Bacterial cells of interest on the imaging slide were then sorted using a laser ejection equipment,and the collected cells were then sequenced individually to identify their taxa.Our strategy allows integrated acquirement of the growth pattern knowledge of a variety of gut bacteria and their genomic information on a single‐cell basis,which should also have great potential in studying many other complex bacterial systems.展开更多
In recent years,much attention has been given to the increase in the Earth-Sun distance,with the modern rate reported as 5-15 m/cy on the basis of astronomical measurements.However,traditional methods cannot measure t...In recent years,much attention has been given to the increase in the Earth-Sun distance,with the modern rate reported as 5-15 m/cy on the basis of astronomical measurements.However,traditional methods cannot measure the ancient leaving rates,so a myriad of research attempting to provide explanations were met with unmatched magnitudes.In this paper we consider that the growth patterns on fossils could reflect the ancient Earth-Sun relationships.Through mechanical analysis of both the Earth-Sun and Earth-Moon systems,these patterns confirmed an increase in the Earth-Sun distance.With a large number of well-preserved specimens and new technology available,both the modern and ancient leaving rates could be measured with high precision,and it was found that the Earth has been leaving the Sun over the past 0.53 billion years.The Earth's semi-major axis was 146 million kilometers at the beginning of the Phanerozoic Eon,equating to 97.6%of its current value.Measured modern leaving rates are 5-14 m/cy,whereas the ancient rates were much higher.Experimental results indicate a special expansion with an average expansion coefficient of 0.57H0 and deceleration in the form of Hubble drag.On the basis of experimental results,the Earth's semi-major axis could be represented by a simple formula that matches fossil measurements.展开更多
Solar-blind deep-ultraviolet(DUV)photodetectors based on Ga2O3have attracted great attention due to their potential applications for many military and civil purposes.However,the development of device integration...Solar-blind deep-ultraviolet(DUV)photodetectors based on Ga2O3have attracted great attention due to their potential applications for many military and civil purposes.However,the development of device integration for optoelectronic system applications remains a huge challenge.Herein,we report a facile method for patterned-growth of high-qualityβ-Ga2O3thin films,which are assembled into a photodetectors array comprising 8×8 device units.A representative detector exhibits outstanding photoresponse performance,in terms of an ultra-low dark current of 0.62 pA,a large Ilight/Idark ratio exceeding 104,a high responsivity of 0.72 A W-1 and a decent specific detectivity of 4.18×1011Jones,upon 265 nm DUV illumination.What is more,the DUV/visible(250/400 nm)rejection ratio is as high as 103 with a sharp response cut-off wave length at 280 nm.Further optoelectronic analysis reveals that the photodetectors array has good uniformity and repeatability,endowing it the capability to serve as a reliable DUV light image sensor with a decent spatial resolution.These results suggest that the proposed technique offers an effective avenue for patterned growth ofβ-Ga2O3thin films for multifunctional DUV optoelectronic applications.展开更多
By using digitized land use maps of Beijing in 1982, 1992 and 1997 and employing GIS spatial analysis techniques, this paper conducts an empirical study on the spatial differentiation and spatial patterns of urban lan...By using digitized land use maps of Beijing in 1982, 1992 and 1997 and employing GIS spatial analysis techniques, this paper conducts an empirical study on the spatial differentiation and spatial patterns of urban land use growth in Beijing in the period of 1982–1997. It is observed that urban land use growth in Beijing went beyond the control of urban planning, in terms of the extraordinary high growth rate and undesired spatial pattern. The rate of urban expansion after 1982, which was predominated by growth of industrial land, was extraordinary high compared to its historical period. While its growth centers have been actively shifting toward the northern part, rather than toward the southern and eastern parts as designated by the latest General Plan (1991–2010) of Beijing, its spatial pattern of urban land use growth in general was in distinct concentric sprawl, which seriously violated the General Plan of Beijing.展开更多
Myogenic regulatory factors(MRFs)serve as crucial transcription factors that regulate muscle development and differentiation.Although MRFs have been extensively studied across various species,their specific role in th...Myogenic regulatory factors(MRFs)serve as crucial transcription factors that regulate muscle development and differentiation.Although MRFs have been extensively studied across various species,their specific role in the muscle development of silver pomfret(Pampus argenteus)has not been fully understood.To elucidate the role of MRFs in the muscle development of silver pomfret,we characterized the muscle growth pattern during the rapid growth phase of this organism(60–120 days post-hatching,Dph).The analysis revealed a distinct transition in growth mechanisms:Hyperplasia dominated muscle development before 90 Dph,whereas hypertrophy became predominant thereafter.The period between 80–90 Dph was a critical transition stage in the muscle growth pattern.Subsequently,five MRF family members,namely,myogenic determination 1(MyoD1),MyoD2,myogenic factor 5(Myf5),Myf6,and myogenin(MyoG),were initially identified in silver pomfret.MRFs exhibited evolutionary conservation and were specifically expressed in the muscle of the silver pomfret.Differential expressions of MRFs were observed across various stages of rapid growth and among individuals with differing growth rates.Upon the addition of exogenous regulatory factors,insulin-like growth factor 1(IGF)-1 and transforming growth factor beta 1(TGF-β1)in vitro,MRFs exhibited the most significant upregulation in response to 100 ng/mL of IGF-1.Conversely,Myf5 demonstrated the most pronounced down-regulation at 100 ng/mL of TGF-β1.For the remaining genes,the most effective suppression was achieved with 1 ng/mL of TGF-β1.These findings indicate the crucial role played by MRFs in the regulation of muscle growth and development.This study not only provides new insights into the functional roles of MRFs in fish muscle development but also establishes a foundation for the optimization of silver pomfret aquaculture strategies through the modulation of these factors.展开更多
摘要A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca3(PO4)2,and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.
基金Supported by National Nature Science Foundation,No.81873111,No.82174454,and No.82074182Natural Science Foundation of Beijing,No.7202066。
摘要Liver is the most common site of metastases of colorectal cancer,and liver metastases present with distinct histopathological growth patterns(HGPs),including desmoplastic,pushing and replacement HGPs and two rare HGPs.HGP is a miniature of tumor-host reaction and reflects tumor biology and pathological features as well as host immune dynamics.Many studies have revealed the association of HGPs with carcinogenesis,angiogenesis,and clinical outcomes and indicates HGP functions as bond between microscopic characteristics and clinical implications.These findings make HGP a candidate marker in risk stratification and guiding treatment decision-making,and a target of imaging observation for patient screening.Of note,it is crucial to determine the underlying mechanism shaping HGP,for instance,immune infiltration and extracellular matrix remodeling in desmoplastic HGP,and aggressive characteristics and special vascularization in replacement HGP(rHGP).We highlight the importance of aggressive features,vascularization,host immune and organ structure in formation of HGP,hence propose a novel"advance under camouflage"hypothesis to explain the formation of rHGP.
基金The Second Batch of Comprehensive Reform and Quality Construction Projects of Party Building and Ideological and Political Education in 2024“Research on the Growth Patterns and Training Path of Excellent Counselors in Private Colleges”(HKDS2024YB11)。
摘要With the rapid development of private higher education,the construction of counselor teams in private universities has become increasingly important.This paper focuses on outstanding counselors in private universities,delving into their growth patterns and proposing targeted training paths based on this analysis.By reviewing relevant theories and analyzing case studies of excellent counselors,it is found that outstanding counselors in private universities exhibit stage-specific characteristics during their development,influenced by personal traits,school environment,career progression,and other factors.In terms of training approaches,efforts should be made to improve selection mechanisms,strengthen training systems,provide career development support,and create a positive work atmosphere,all aimed at enhancing the overall quality of the counselor team in private universities and better serving student growth and institutional development.
基金Project supported by the Shandong Science and Technology Planning Project (Nos.2010G0020232,2010HM053,and 2010GSF10269)the Shandong Provincial Natural Science Foundation (No.ZR2012HM087)+1 种基金the Jinan Science and Technology Planning Project(No.JN201202042)the Shandong University Project(Nos.2011JC009 and 2012JC031),China
摘要Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.Methods:Forty-five patients with normal occlusion(23 males,22 females) were included in this study.Among these patients,20 displayed the vertical growth pattern,and 20 had the horizontal growth pattern,while the remaining patients displayed the average growth pattern.All of the patients underwent dental cone beam computed tomography(CBCT),which included the region of the mandibular posterior teeth and the alveolar.A linear regression analysis and a correlation analysis between the facial height index(FHI) and the alveolar bone morphology were performed.Results:The inclination of the molars,the thickness of the cortical bone,and the height of the mandibular bone differed significantly between patients with the horizontal growth pattern and those with the vertical growth pattern(P<0.05).Significant positive correlations were found between:the FHI and the inclination of the molars;the FHI and the thickness of the cortical bone;and the FHI and the height of the mandibular bone.Conclusions:The mandibular posterior tooth-alveolar bone complex morphology may be affected by growth patterns.
基金granted by the National Natural Science Foundation of China (Grant No. 41172047, 41272062)the Open Fund of the State Key Laboratory of Ore Deposit Geochemistry (Institute of Geochemistry, Chinese Academy of Sciences, Guiyang) (Grant No. 201308)
摘要The Baiyunpu deposit lies in the southwest plunging Dachengshan anticline in central Hunan, which is a large Pb-Zn polymetallic deposit. The orebodies were surrounded by the Qiziqiao Formation limestone in the Middle Devonian, and its geological occurrence is consistent with the wall rocks. A large number of spheroidal pyrite aggregates are found unevenly distributed in the ores. The spheroidal aggregates are made up of kernels and concentric rings. The kernels are composed of approximately epigranular pyrite nanocrystals, while the rings are composed of accumulated pyrite microcrystals growing along the radial direction. The spheroidal pyrite aggregate and its outer zones can be divided into five areas(A–E). The results of electron probe micro analysis(EPMA) show that from the zone A1 to B, Co/Ni 〈1, the sum of Co and Ni is 0.08%–0.26%, S/Fe increases from 2.06 to 2.15. While from the zone C to E, Ni cannot be detected and S/Fe decreases from 2.22 to 2.08. Powder X-ray diffraction(XRD) analysis in the micro zone shows obvious crystalline characteristics in the aggregates. Moving from the inside outwards, the maximum diffraction peak intensity of the(111) and(220) crystal planes of pyrite increases, and the crystallinity improves. The degree of change in the(111) plane is the most prominent. Considering the theory of crystal growth along with the geologic features of the depositional environment where the spheroidal pyrite aggregates developed, we confirm that the spheroidal aggregates are the result of nano-micro crystalline gathering and growth occurring by the following sequence of processes:nano-crystalline nucleation and growth, gathering into a ball, oriented growth of microcrystals, continuous accumulation, and adjustment of grain boundaries. The formation of the spheroidal pyrite aggregates in the late Qiziqiao Formation of the Middle Devonian occurred in a neutral to weak alkaline and reductive sedimentary environment in the normal oxygen-rich shallowwater carbonate platform edge. The variations in the S/Fe ratio and crystallisation characteristics indicate that during pyrite crystal growth, the sulphur fugacity was high locally and rose constantly, the degree of supersaturation decreased locally and the growth environment was stable relatively.
摘要A study on seasonal abundance,morphometric and meristic data,growth pattern,condition fector,sex ratio and gonadosomatic index of Liza falcip-innis(Wlenciennes,1836)from the Ojo axis of Badagry creek,Nigeria was conducted from May 2019 to March 2020.A total of 1012 species were randomly selected,having 499 females and 513 males.The length frequency analysis and length-weight relationships(LWR)were determined.Sex ratio was determined by Chi-square analysis.The results showed that morphometric data are:0.5-2.5 mm for ED,2.1-12 mm for HL,1.7-8.1 mm for HD,2.5-11.7 for BD,2.6-233.3 mm for TL and 9.23-1006 g for BW for the combined sexes.The slope(b)shows an allometric growth pattern.The intercept'a'and slope'b'of the LWR(LogW=a+bLogL)were Log W=15.39+0.34 LogL(r=0.54)for combined sexes,Log W=12.49+0.02 log L(r=0.38)for males and Log W=18.23+0.01 log L(r=0.16)for females.The length frequency distribution indicated that species were dominated by two year classes(Ages 1 and 2).Condition factors were generally low.The values ranged between 0.68-0.85 for combined sexes.The gonadosomatic index for female was highest in August,2019(17.77%)with Mean±SD of 2.88±0.75;which indicated the peak of spawning period in the study area.Sex ratio difference was significant(P<0.05).Sexual differences were significant;the females are phenotypically larger than the male.
基金the National Natural Science Foundation of China(Grant No.30060069)
摘要The clonal growth pattern of Sabina vulgaris, a coniferous clonal plant in Mu Us sandland, Inner Mongolia Autonomous Region was surveyed. The results showed that with the stolon extending, internode length and branching angle decreased, the branching intensity increased gradually within the 3 m range from the edge of the shrub to its center along the stolon. Internode length, branching intensity and branching angle were 5.9 cm, 4.4 and 55.3°in the shrub, and 1.6 cm, 13.7 and 38.3°at the edge of the shrub, respectively. The clonal architecture exhibited plasticity. The internode length, branching intensity and ramet length changed with an exponential model with extention of the stolon. The stolon of S. vulgaris was monopodial branching, and each ramet should possess more than 3 adventitious roots. Ramets could take on the phenomenon of 搒elf-thinning?with clonal growth. There was a prior grade in allocation of the nutrients gained from heterogeneous space. The clonal architecture of S. vulgaris was the 搈ixed?type.
摘要Tree growth is affected by environmental factors, climate condition and tree age. The objective of this study was to evaluate the growth patterns of Chamaecyparis obtusa (C. obtusa) stand in the Gyeongnam province. Data was collected from two cities and one county by using sample quadrats of 20 * 20 m. A total of 11 quadrats were used to collect tree height, diameter at the breast height (DBH), annual growth rings and soil data. The data analysis of soil moisture content, pH, organic matter (%), EC (cmol + /kg of soil), and available phosphorous was conducted. Growth ring was analyzed by using computer based software and the ages of the trees were identified. Average growth of height and DBH was computed from the surveyed data and annual growth of each tree was assessed by computer based reading of annual growth rings. The results of the study revealed that tree growth showed a reducing trend along the longevity. It was identified that soil pH, age, variation in annual average temperature, and altitude were the main factors related with growth of C. obtusa trees along the life of the stand.
基金Interim results for the state social science foundation key project "Raising Macro Regulation Level and Maintain Fast and Steady Economic Growth" (approve No. 09&ZD017) and "Funding Program for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality" (approve No. 00491162340 142).
摘要The BRICS (Brazil, Russia, India, China and South Africa) and other emerging economies have become a driving global force for the past twenty years. However, their growth patterns are obsolete, impeding the quality and competitiveness of their economic growth, while simultaneously threatening the sustainability of their economic convergence with developed nations. Transforming the domestic growth pattern-the solution to the middle-income trap-has therefore become a key priority for each of these economies. This paper presents a comparative analysis of how to transform the pattern of economic growth in BRICS and achieve sustainable economic convergence with a comparative analysis of the pattern of economic growth and problems among BRICS countries.
摘要Using Cobb-Douglas production function and Solow Residual, this study establishes a discriminant index to measure the intensive index of coal-production at the section-level, so as to analyze the transfer trend of the growth pattern of Jiangsu's coal-production since 1990s. The research shows that the transition of coal production in Jiangsu Province has mainly experienced three phases, which are the quick transition phase from extensive growth to intensive growth (from 1990 to 1994), the fluctuation phase (from 1995 to 1999), and the transition back phase from intensive growth to extensive growth (from 2000 to 2003). On the whole, the coal production in Jiangsu Province nowadays is still featured by extensive growth pattern and largely dependent upon capital inputs. Finally, from the aspect of the technology progress, improving the qualities of labor, changing product structures and improving enterprise management, this study puts forward suggestions on how to transfer the growth pattern of Jiangsu's coal-production into intensive type.
摘要Over the past 20 years, China has made spectacular achievements in economic growth as well as in thetransformation of economic growth pattern. Industrial structure is being updated, and technology is playing a more andmore important role in economic development. The energy and resource consumption in many industries and enterprisesare reducing. However, we should realize that there are still many problems in changing the economic growth pattern,such as high input, high consumption, high discharge, inharmony, recycling difficulty, and low efficiency, which havegreatly impaired and restrict Chinese economic development. Therefore, the fundamental change of the economic growthpattern is inevitable. Based on the analysis on the status quo and the exploit of resources, this paper suggests that thetransformation from unsustainable to sustainable growth is the only choice in changing the economic growth pattern. Inaddition, the transformation should not completely rely on the fundamental effects of market mechanism. We should makefull use of the power of governments to speed up the transformation of economic system.
基金supported by the National Natural Science Foundation of China(Nos.42277448,42330501,41971104,and 41807431)。
摘要Intra-annual climatic variability plays a critical role in regulating wood formation dynamics during the growing season,particularly in seasonally arid regions—such as the Qinling Mountains,China,and Mediterranean forests—where trees exhibit bimodal radial growth patterns as an adaptive response to water stress.While these growth patterns reflect immediate climatic conditions,the role of ecological memory,specifically vegetation growth carryover(VGC)and lagged climate effects(LCEs),remains poorly quantified.We employed the Vaganov–Shashkin(VS)model to analyze intra-annual bimodal growth patterns in two regions and used a vector autoregressive model with impulse response functions to assess the duration and intensity of VGC and LCE on tree-ring growth and remote sensing vegetation indices(leaf area index(LAI)and gross primary productivity(GPP)).Our results revealed bimodal growth patterns with spring and autumn peaks,but the autumn peak occurred earlier in the Qinling Mountains(August–October)than in Mediterranean forests(late September–October).VGC exerted the strongest influence on tree-ring growth in the first year,diminishing significantly after eight years in both regions(p<0.01).Tree-ring growth exhibited positive LCE responses to precipitation and soil moisture but negative responses to temperature(p<0.05).Remote sensing indices(LAI and GPP)displayed stronger VGC effects in the Qinling Mountains than in Mediterranean forests.While both LAI and GPP responded positively to soil moisture,temperature-induced LCE was positive in the Qinling Mountains but negative in the Mediterranean forests(p<0.05).Overall,VGC was the dominant ecological memory effect in both regions.Our results suggest that coupling the VGC and LCE of multiple vegetation growth indicators at multiple scales has the potential to improve the accuracy of global dynamic vegetation models.
基金This work was supported by National Natural Science Foundation of China(41541042)National Natural Science Foundation of Shanghai(17ZR1413000)Shanghai Leading Academic Discipline Project(Fisheries Discipline)and Laboratory for Marine Fisheries Science and Food Production Processes,Qingdao National Laboratory for Marine Science and Technology(2017-1A03).
摘要Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and increment deposition.In this study,the gladius growth patterns with somatic growth and gonad development were evaluated for two geographic stocks of the jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean.The microstructure and periodicity of the gladius growth increments were also investigated.Results showed varied correlations between four gladius morphometric characteristics with dorsal mantle length,while growth in body weight almost followed a power model.Sexual gladius growth patterns occurred with gonad development,possibly due to different biological functions of these gladius parts and sex-specific energetic allocations.Gladius increments were observed formation in the stem and lateral plate and could be consistently enumerated.The daily periodicity of increment deposition,at least over 144 days old,was validated by comparing gladius increments with the ages obtained from the statoliths.The different oceanographic conditions between two areas likely influence the gladius growth and increment deposition and promote higher increment counts in squid from equatorial waters.Above all,these results provided new information on gladius microstructures and growth increment in different stocks of D.gigas and confirmed the use of this tissue for size-specific growth and age determination.
基金National Social Sciences Foundation of China,Key Program(10ZD&016)National Natural Sciences Foundation of China(41371147,41401128)2014 Cultivation and Action Plan of Excellent Doctoral Dissertations,East China Normal University(PY2014002)
摘要Achieving dual goals of economic growth and carbon emission reduction is a major issue in China. In this paper we deifne three economic growth patterns (green growth, brown growth and black growth) according to the relationship between economic scale and carbon emissions, and then trace the historical trajectory of economic growth over the last 40 years. Granger causality is used to test China’s economic growth and carbon emission linkage. We argue that green growth means that the rate of carbon emission reduction is faster than the increase in GDP. When carbon intensity reduction is slower than GDP growth, brown growth occurs. Black growth occurs when both carbon intensity and economic scale increase. For China, we denote the four periods of black growth (1971–1977), brown growth (1978–2001), black growth (2002–2004), and brown growth (2004–2010). Granger causality tests indicate that mutual causality between carbon emissions and economic growth exists in the short term, but not the long term. In order to achieve the goals of economic growth and carbon intensity reduction, it is necessary for China to actively participate in global carbon reduction activities, technological innovation and ecological civilization construction.
基金We are grateful to the National Natural Science Foundation of China(Grants 22122702,21735004,and 21775128)Innovative research team of high‐level local universities in Shanghai(SHSMU‐ZLCX20212601).
摘要Despite the fast progress in our understanding of the complex functions of gut microbiota,it is still challenging to directly investigate the in vivo microbial activities and processes on an individual cell basis.To gain knowledge of the indigenous growth/division patterns of the diverse mouse gut bacteria with a relatively high throughput,here,we propose an integrative strategy,which combines the use of fluorescent probe labeling,confocal imaging with single‐cell sorting,and sequencing.Mouse gut bacteria sequentially labeled by two fluorescent D‐amino acid probes in vivo were first imaged by confocal microscopy to visualize their growth patterns,which can be unveiled by the distribution of the two fluorescence signals on each bacterium.Bacterial cells of interest on the imaging slide were then sorted using a laser ejection equipment,and the collected cells were then sequenced individually to identify their taxa.Our strategy allows integrated acquirement of the growth pattern knowledge of a variety of gut bacteria and their genomic information on a single‐cell basis,which should also have great potential in studying many other complex bacterial systems.
基金supported by the National Basic Research Program of China(2010CB328201)the National High Technology Research and Development Program of China(2006AA12Z310)the National Natural Science Foundation of China(60772003)
摘要In recent years,much attention has been given to the increase in the Earth-Sun distance,with the modern rate reported as 5-15 m/cy on the basis of astronomical measurements.However,traditional methods cannot measure the ancient leaving rates,so a myriad of research attempting to provide explanations were met with unmatched magnitudes.In this paper we consider that the growth patterns on fossils could reflect the ancient Earth-Sun relationships.Through mechanical analysis of both the Earth-Sun and Earth-Moon systems,these patterns confirmed an increase in the Earth-Sun distance.With a large number of well-preserved specimens and new technology available,both the modern and ancient leaving rates could be measured with high precision,and it was found that the Earth has been leaving the Sun over the past 0.53 billion years.The Earth's semi-major axis was 146 million kilometers at the beginning of the Phanerozoic Eon,equating to 97.6%of its current value.Measured modern leaving rates are 5-14 m/cy,whereas the ancient rates were much higher.Experimental results indicate a special expansion with an average expansion coefficient of 0.57H0 and deceleration in the form of Hubble drag.On the basis of experimental results,the Earth's semi-major axis could be represented by a simple formula that matches fossil measurements.
基金supported by the National Natural Science Foundation of China(NSFC,Nos.51902078,62074048)the Fundamental Research Funds for the Central Universities(PA2020GDKC0014,JZ2020HGTB0051,JZ2018HGXC0001)the Anhui Provincial Natural Science Foundation(2008085MF205)。
摘要Solar-blind deep-ultraviolet(DUV)photodetectors based on Ga2O3have attracted great attention due to their potential applications for many military and civil purposes.However,the development of device integration for optoelectronic system applications remains a huge challenge.Herein,we report a facile method for patterned-growth of high-qualityβ-Ga2O3thin films,which are assembled into a photodetectors array comprising 8×8 device units.A representative detector exhibits outstanding photoresponse performance,in terms of an ultra-low dark current of 0.62 pA,a large Ilight/Idark ratio exceeding 104,a high responsivity of 0.72 A W-1 and a decent specific detectivity of 4.18×1011Jones,upon 265 nm DUV illumination.What is more,the DUV/visible(250/400 nm)rejection ratio is as high as 103 with a sharp response cut-off wave length at 280 nm.Further optoelectronic analysis reveals that the photodetectors array has good uniformity and repeatability,endowing it the capability to serve as a reliable DUV light image sensor with a decent spatial resolution.These results suggest that the proposed technique offers an effective avenue for patterned growth ofβ-Ga2O3thin films for multifunctional DUV optoelectronic applications.
基金The Knowledge Innovation Project of CAS, No.KZCX2-310-01, No.KZCX2-307 National Natural Science Foundation of China, No. 40101010
摘要By using digitized land use maps of Beijing in 1982, 1992 and 1997 and employing GIS spatial analysis techniques, this paper conducts an empirical study on the spatial differentiation and spatial patterns of urban land use growth in Beijing in the period of 1982–1997. It is observed that urban land use growth in Beijing went beyond the control of urban planning, in terms of the extraordinary high growth rate and undesired spatial pattern. The rate of urban expansion after 1982, which was predominated by growth of industrial land, was extraordinary high compared to its historical period. While its growth centers have been actively shifting toward the northern part, rather than toward the southern and eastern parts as designated by the latest General Plan (1991–2010) of Beijing, its spatial pattern of urban land use growth in general was in distinct concentric sprawl, which seriously violated the General Plan of Beijing.
基金the National Key R&D Program of China(No.2022YFD2400103)the Major Project of Science,Technology and Innovation 2025 in Ningbo City(No.2021Z003)+3 种基金the Public Welfare Program of Ningbo City(Science and Technology Special Commissioner Project)(No.2022S204)the General Scientific Research Projects of Zhejiang Provincial Department of Education(No.Y202249062)the National Natural Science Foundation of China(No.42306114)the KC Wong Magna Fund in Ningbo University。
摘要Myogenic regulatory factors(MRFs)serve as crucial transcription factors that regulate muscle development and differentiation.Although MRFs have been extensively studied across various species,their specific role in the muscle development of silver pomfret(Pampus argenteus)has not been fully understood.To elucidate the role of MRFs in the muscle development of silver pomfret,we characterized the muscle growth pattern during the rapid growth phase of this organism(60–120 days post-hatching,Dph).The analysis revealed a distinct transition in growth mechanisms:Hyperplasia dominated muscle development before 90 Dph,whereas hypertrophy became predominant thereafter.The period between 80–90 Dph was a critical transition stage in the muscle growth pattern.Subsequently,five MRF family members,namely,myogenic determination 1(MyoD1),MyoD2,myogenic factor 5(Myf5),Myf6,and myogenin(MyoG),were initially identified in silver pomfret.MRFs exhibited evolutionary conservation and were specifically expressed in the muscle of the silver pomfret.Differential expressions of MRFs were observed across various stages of rapid growth and among individuals with differing growth rates.Upon the addition of exogenous regulatory factors,insulin-like growth factor 1(IGF)-1 and transforming growth factor beta 1(TGF-β1)in vitro,MRFs exhibited the most significant upregulation in response to 100 ng/mL of IGF-1.Conversely,Myf5 demonstrated the most pronounced down-regulation at 100 ng/mL of TGF-β1.For the remaining genes,the most effective suppression was achieved with 1 ng/mL of TGF-β1.These findings indicate the crucial role played by MRFs in the regulation of muscle growth and development.This study not only provides new insights into the functional roles of MRFs in fish muscle development but also establishes a foundation for the optimization of silver pomfret aquaculture strategies through the modulation of these factors.