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Physics-Informed Surrogate Modelling of Concrete Self-Healing via Coupled FEM-ML with Active Learning 认领 引用
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作者 Ajitanshu Vedrtnam KishorKalauni +2 位作者 Shashikant Chaturvedi Peter Czirak Martin T.Palou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第2期316-344,共29页
This study presents a physics-informed modelling framework that combines finite element method(FEM)simulations and supervised machine learning(ML)to predict the self-healing performance of microbial concrete.A FEniCS-... This study presents a physics-informed modelling framework that combines finite element method(FEM)simulations and supervised machine learning(ML)to predict the self-healing performance of microbial concrete.A FEniCS-based FEM platform resolves multiphysics phenomena including nutrient diffusion,microbial CaCO3 precipitation,and stiffness recovery.These simulations,together with experimental data,are used to train ML models(Random Forest yielding normalized RMSE≈0.10)capable of predicting performance over a wide range of design parameters.Feature importance analysis identifies curing temperature,calcium carbonate precipitation rate,crack width,bacterial strain,and encapsulation method as the most influential parameters.The coupled FEM-ML approach enables sensitivity analysis,design optimization,and prediction beyond the training dataset(consistently exceeding 90%healing efficiency).Experimental validation confirms model robustness in both crack closure and strength recovery.This FEM–ML pipeline thus offers a generalizable,interpretable,and scalable strategy for the design of intelligent,self-adaptive construction materials. 展开更多
关键词 Self-healing concrete finite element modelling machine learning bio-concrete healing optimization microbial calcium carbonate precipitation
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Self-healing of asphalt materials–part 1:Mechanisms,influencing factors,and evaluation methods 认领 引用
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作者 Carlos D.A.Loureiro Hugo M.R.D.Silva Joel R.M.Oliveira 《Journal of Road Engineering》 EI CAS 2026年第2期201-231,共31页
The self-healing behavior of asphalt materials is increasingly recognized as a promising strategy to extend pavement life and reduce maintenance costs.However,research in this area remains fragmented,lacking a unified... The self-healing behavior of asphalt materials is increasingly recognized as a promising strategy to extend pavement life and reduce maintenance costs.However,research in this area remains fragmented,lacking a unified,critical synthesis of fundamental mechanisms and evaluation methods.This review paper,the first part of a two-part study,addresses this gap by consolidating current knowledge on self-healing in asphalt materials.The article first explores the theoretical principles that govern healing phenomena,including capillary flow and molecular diffusion,as well as viscoelastic phenomena(thixotropic recovery and steric hardening)that can inflate apparent healing if not controlled.It then examines how internal factors(e.g.,binder chemistry,oxidative aging,and air-void content)and external factors(e.g.,temperature,rest periods,and traffic loading)influence the healing potential.Special focus is given to multiscale evaluation methods,ranging from rheological recovery tests at the binder level to assessments of stiffness recovery,fatigue resistance,and fracture at higher scales.Emerging nondestructive methods,including computed tomography and acoustic emission,are also reviewed.By integrating dispersed findings into a coherent framework,this work contributes to the development of more reliable and standardized healing assessment methods,laying the scientific groundwork for Part 2,which will address advanced self-healing strategies,practical implementation,and environmental and economic evaluation. 展开更多
关键词 Self-healing asphalt Healing mechanism Influencing factor Multiscale evaluation Assessment method Pavement durability
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Healing efficiency and mechanical properties of repeatable self-healing carbon fiber reinforced polymer composites 认领 引用
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作者 Zhen Wang Yan Li 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第3期393-403,共11页
Repeatable self-healing composites have attracted attention for their ability to extend the service life and reduce overall life cycle costs in long-term applications.In this study,repeatable self-healing carbon fiber... Repeatable self-healing composites have attracted attention for their ability to extend the service life and reduce overall life cycle costs in long-term applications.In this study,repeatable self-healing carbon fiber reinforced polymer composites(RSH-CFRPs)were produced by dispersing microcapsules containing hardener and hollow glass fibers containing two types of microcapsules and self-healing resin(HGFs-Ms)into the matrix.The repeated self-healing efficiency and mechanical properties were studied using tensile,three-point flexure,short-beam shear,and double-cantilever beam tests.The results showed that both the first and second self-healing efficiencies in mode I interlaminar fracture toughness of the RSH-CFRPs exceeded 75%.Moreover,the incorporation of HGFs-Ms and microcapsules containing hardener enhanced the interlaminar fracture toughness and interlaminar shear strength by 28.36%and 26.19%,respectively.However,the RSH-CFRPs exhibited lower tensile and flexural properties compared to laminates without HGFs-Ms and microcapsules.Furthermore,the failure mechanisms of the RSH-CFRPs were extensively analyzed through macroscopic and microscopic observations of the fracture surfaces.The outcomes of this study offer valuable insights for the design and optimization of RSH-CFRPs. 展开更多
关键词 Repeatable self-healing Carbon fiber reinforced polymer composites Mechanical properties Healing mechanism Fracture mechanism
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Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing 认领 引用 被引量：1
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作者 Lijuan Zong Chong Liu +11 位作者 Li Zhang Xueyou Tao Qingyan Tian Xiaokai Zhou Yu Wang Na Shen Jiaming Gong Qingyuan Zhuang Tong Wang Wentao Liu Ying Shen Liang Hu 《Journal of Biomedical Research》 CAS CSCD 2026年第2期120-133,共14页
Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited ... Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited by the need for wound exposure and by increased pain.Our preliminary study demonstrated the innovative application of remote NMES(rNMES)to the skeletal muscle of the distal calf,which showed the potential to accelerate wound healing in remote areas.rNMES was effective in human clinical trials in our previous work,although the underlying mechanisms remain unclear.As rNMES is often used to stimulate muscle contraction in long-term bedridden patients,we analyzed data from the Gene Expression Omnibus(GEO)database and found that exercise promotes midkine(MDK)expression in muscle.MDK is a small secreted heparin-binding protein that interacts with multiple cell surface receptors to promote growth.In the present study,we found that MDK significantly enhanced macrophage efferocytosis in a low-density lipoprotein receptor-related protein 1(LRP1)-dependent manner.Our findings demonstrate that rNMES upregulates MDK expression in skeletal muscles through the AMPK-ERK axis,facilitating its delivery to wounds through the circulatory system and promoting LRP1-mediated efferocytosis of apoptotic cells,thereby expediting wound healing. 展开更多
关键词 wound healing remote neuromuscular electrical stimulation efferocytosis MDK LRP1
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Exosome-me diate d regulation of macrophage polarization:A novel therapeutic strategy for diabetic wound healing 认领 引用
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作者 Jia-Le Ma Ling-Xiao Wang +4 位作者 Hao Yu Zhi-Kang Zhu Jia-Hong Xu Jia-Qi Lou Shou-Jie Wang 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2026年第1期115-118,共4页
Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic woun... Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic wound,a significant complication,is characterized by delayed healing,high disability rates,and elevated mortality[2].The challenges of wound healing in diabetic patients,compounded by their high morbidity and mortality rates,have drawn growing attention in biomedical research. 展开更多
关键词 wound healing diabetes mellitus exosome mediated regulation diabetic wound healing biomedical research macrophage polarization
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Bacterial biosurfactant-reinforced chitooligosaccharide/polyvinyl alcohol hydrogels accelerate methicillin-resistant Staphylococcus aureus-infected wound healing by attenuating its virulence factors 认领 引用
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作者 Geum-Jae Jeong Dong-Joo Park +6 位作者 Ju-Hong Kang Se-Chang Kim Yu-Jin Ahn Kyung-Jin Cho Fazlurrahman Khan Won-Kyo Jung Young-Mog Kim 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2026年第1期125-149,共25页
Methicillin-resistant Staphylococcus aureus(MRSA) causes widespread infections and poses serious public health concerns. Its high level of resistance to multiple antibiotics has garnered growing interest in identifyin... Methicillin-resistant Staphylococcus aureus(MRSA) causes widespread infections and poses serious public health concerns. Its high level of resistance to multiple antibiotics has garnered growing interest in identifying and applying novel antibacterial compounds derived from natural sources. In this study, we purified a biosurfactant(BS) from Bacillus rugosus HH2 to develop a natural antibacterial agent. This agent was then reinforced with chitooligosaccharide(COS) and polyvinyl alcohol(PVA) to create a hydrogel that promoted healing in MRSA-infected wounds. The COS/PVA/BS hydrogel was readily fabricated via the freeze-thaw method and demonstrated excellent mechanical strength, biological activity,and biocompatibility. In vitro assays confirmed that the hydrogel significantly enhanced the proliferation, migration, angiogenesis, and extracellular matrix deposition of fibroblasts,keratinocytes, and endothelial cells. Moreover, it exhibited strong bacteriostatic and bactericidal activities against MRSA, along with potent antibiofilm activity and inhibition of virulence factors relevant to MRSA-induced wound infections. Its anti-virulence effects have been linked to the downregulation of quorum sensing and virulence-related genes in MRSA. In an in vivo model of MRSA-induced infection, the COS/PVA/BS hydrogel significantly accelerated wound healing and markedly reduced the MRSA burden. Immunofluorescence staining confirmed enhanced neovascularization and regulated macrophage responses,underscoring the angiogenic and immunomodulatory effects of the hydrogel. Overall,the COS/PVA/BS hydrogel represents a promising therapeutic strategy for addressing antibiotic-resistant bacterial infections and promoting wound repair, supported by the use of common raw materials, a simple fabrication process, and high-yield production of natural antibacterial agents. 展开更多
关键词 Hydrogel Biosurfactant Methicillin-resistant Staphylococcus aureus Bacterial infection Wound healing Virulence factor
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Controlled release of berberine modulates the wound microbiome to accelerate wound healing 认领 引用
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作者 Zeyu Xu Lixiang Zhang +8 位作者 Juntong Guo Qing Xia Zhengping Ge Ziyu Wang Ruoyu Mu Jie Dong Zhiguo Qin Jun Chen Yiwei Wang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2026年第2期209-225,共17页
The wound microbiome has been shown to play a significant role in influencing the wound healing process.Coptis chinensis,a traditional Chinese medicine(TCM)known for its heat-clearing properties,contains berberine(BER... The wound microbiome has been shown to play a significant role in influencing the wound healing process.Coptis chinensis,a traditional Chinese medicine(TCM)known for its heat-clearing properties,contains berberine(BER)as major active ingredient,which exhibits notable antibacterial activity.In this study,we investigated the effect of BER on wound healing and wound microbiome through three distinct delivery strategies,including solution form,burst-release scaffolds(PCL/BER),and sustained-release scaffolds(PCL/PLGA/BER),compared with an untreated negative control(NC)group.Drug release studies confirmed that PCL/BER caused a pronounced burst release,while the incorporation of PLGA enabled sustained release of BER for up to 120 h.Further in vivo studies showed that the sustained BER release from the PCL/PLGA/BER resulted in the most effective improvement in wound healing.Microbiome analysis using 16S rRNA sequencing identified Staphylococcus xylosus(S.xylosus)as the key species influencing wound healing outcomes in response to BER delivery.S.xylosus overabundance in the NC group and its depletion in the BER solution and burst BER release groups impaired wound healing.In contrast,sustained BER delivery maintained an optimal S.xylosus abundance that promoted a favorable immune microenvironment by modulating CXCL10 and(IFN-α)expression.Our findings emphasize the importance of coordinating drug release kinetics with microbiome dynamics for optimal wound healing outcomes and provide valuable insights for developing future delivery systems for heat-clearing TCMs,with a focus on microbiome-modulation therapeutic strategies. 展开更多
关键词 Wound microbiome Wound healing Berberine Controlled release Staphylococcus xylosus
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Hybrid Probiotic Hydrogel With Curcumin-Loaded MnO2Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation 认领 引用
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作者 Xianfeng Wang Yuwen Shangguan +4 位作者 Hao Nan Lingze Chen Chencheng Gu Litao Yan Huan Li 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期407-421,共15页
Skin wound injuries are often accompanied by bacterial infections and severe inflammation.Especially,M1-type macrophages at the wound site can trigger a cascade of inflammatory responses,mediating a vicious cycle of i... Skin wound injuries are often accompanied by bacterial infections and severe inflammation.Especially,M1-type macrophages at the wound site can trigger a cascade of inflammatory responses,mediating a vicious cycle of inflammation.Meanwhile,hypoxia further exacerbates vascular damage and constriction in the wound microenvironment,thereby impeding the healing process of infected wounds.To address this,we propose a"trinity"strategy integrating skin microbiota homeostasis regulation,immune microenvironment remodeling,and oxygen generation to promote blood flow for wound repair.A thermos-sensitive hydrogel was utilized to deliver nano-hybridized probiotics(LGG@NP-Gel).The hybrid probiotics were constructed by modifying Lactobacillus rhamnosus GG(LGG)with curcumin-loaded manganese dioxide.LGG exerts antibacterial effects through acid secretion and bioantagonism while promoting M2 macrophage polarization.The HMnO2component releases curcumin,further enhancing M2 macrophage polarization.Additionally,HMnO2scavenges reactive oxygen species(ROS)and generates oxygen,improving local oxygenation and blood supply to accelerate wound healing.In a murine wound model,LGG@NP-Gel significantly enhanced the healing efficacy. 展开更多
关键词 macrophage polarization nano-hybridized probiotics reactive oxygen species skin microbiota wound healing
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Synergistic antibacterial and anti-inflammatory potentials of dual-loaded self-healing hydrogel for methicillin-resistant Staphylococcus aureus-infected wound healing 认领 引用
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作者 Sangyu Hu Weigang Zhong +5 位作者 Yuzhu Pei Yutong Zhou Jianfeng Wang Xuming Deng Zihao Teng Lei Xu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期242-256,共15页
The emergence of drug-resistant bacterial infection and persistent biofilm colonization pose a rigorous challenge to effective wound healing and regeneration,necessitating the innovative therapeutic strategies to comb... The emergence of drug-resistant bacterial infection and persistent biofilm colonization pose a rigorous challenge to effective wound healing and regeneration,necessitating the innovative therapeutic strategies to combat these pressing clinical crises.Herein,nortriptyline,a novel United States Food and Drug Administration(FDA)-approved tricyclic antidepressant was uncovered to effectively potentiate bactericidal activities ofβ-lactam antibiotics against methicillin-resistant Staphylococcus aureus(MRSA).Mechanistically,nortriptyline functions by disrupting the microbial iron homeostasis and potentiation of Fenton chemistry-mediated oxidative stress,concomitant with metabolic reprogramming via tricarboxylic acid(TCA)cycle dysregulation and membrane destabilization.To enhance combination therapy-mediated therapeutic potential in wound management,the dual-loaded self-healing hydrogel OHA-PLL@AN was engineered to exhibit excellent biocompatibility and antibacterial potentials through molecular cross-linking of oxidized hyaluronic acid(OHA)andε-polylysine(PPL).The therapeutic efficacy of OHA-PLL@AN was further validated in a murine model with MRSA-infected cutaneous wounds.OHA-PLL@AN therapy significantly attenuated the inflammatory response,concurrently promoting angiogenesis and accelerating the cutaneous wounds healing.Collectively,these findings underscore the dual drug-loaded self-healing hydrogel OHA-PLL@AN with anti-infection and anti-inflammatory properties as a novel therapeutic strategy for drug-resistant bacterial infected wounds therapy. 展开更多
关键词 MRSA Antibacterial Nortriptyline β-lactam antibiotics Hydrogel Wound healing
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Precision Imaging for Optimized Crohn's Disease Management:Navigating the Evolution of Objective Healing Goals 认领 引用
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作者 Ziman Xiong Yufan Wang +2 位作者 Shuxin Luo Zhen Li Yaqi Shen 《iRADIOLOGY》 CSCD 2026年第2期113-126,共14页
As the management of Crohn's disease(CD)shifts from symptom control toward objective healing targets,the limitations of conventional assessments underscore the need for imaging to transcend detection and guide per... As the management of Crohn's disease(CD)shifts from symptom control toward objective healing targets,the limitations of conventional assessments underscore the need for imaging to transcend detection and guide personalized therapy.Although endoscopy remains central for the evaluation of CD,its limitations in the assessment of submucosal lesions and penetrating complications necessitate advanced imaging solutions.Noninvasive multimodal imaging techniques,including computed tomography enterography,magnetic resonance enterography,and intestinal ultrasound,have emerged as indispensable tools in the management of CD.These modalities enable a comprehensive evaluation of transmural inflammation and extramural complications while also providing prognostic information to guide therapeutic decisions.This review focuses on the transformative role of multimodal imaging in the modern management landscape for CD.We discuss how imaging facilitates baseline risk stratification,quantification of transmural healing as a deep therapeutic endpoint,and differentiation of inflammatory from fibrotic strictures to guide medical versus surgical decision-making.Furthermore,we examine the integration of artificial intelligence and body composition analysis,providing tools enabling personalized prognostication.By aligning imaging innovations with evolving clinical goals,we propose a clinically oriented framework for integrating imaging-defined transmural healing into precision-based CD management. 展开更多
关键词 artificial intelligence Crohn's disease disease management multimodal imaging transmural healing
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Recent Advances in Natural Polysaccharide-Based Materials for Wound Healing:Chitosan,Konjac Glucomannan and Cellulose 认领 引用
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作者 Jin Shang Weimin Zhang +4 位作者 Landuo Zhang Xiangwen Li Qi Wang Peng Zhao Liangliang Duan 《Journal of Renewable Materials》 EI CAS 2026年第4期49-98,共50页
Wound healing is a complex and dynamic process essential for restoring the integrity of damaged skin.It requires wound dressings that actively regulate the wound microenvironment by preventing infection,maintaining mo... Wound healing is a complex and dynamic process essential for restoring the integrity of damaged skin.It requires wound dressings that actively regulate the wound microenvironment by preventing infection,maintaining moisture balance,allowing gas exchange,and managing exudate.Natural polysaccharides,such as konjac glucomannan(KGM),chitosan,and cellulose,are well suited to this role because of their biocompatibility,biodegradability,and intrinsic bioactivity.Extensive research has focused on developing polysaccharide-based wound dressings with enhanced functionality to promote healing.This review examines recent scientific research published mostly in the past five years on the development and application of chitosan,KGM and cellulose-based macromolecules for wound dressing fabrication,including hydrogels,sponges,fibers,and other forms.It explores how their structure-propertyfunction relationships connect primary composition and inter-component interactions(e.g.,hydrogen bonding,ionic complexation,covalent crosslinking)to key performance metrics(antibacterial efficacy,hemostatic activity,moisture management such as swelling and water vapor transmission rate,and mechanical robustness).The advantages and disadvantages of various methods for preparing materials of the same type using the same polysaccharide are also discussed with quantitative comparisons across studies to provide clear insights into the healing effects of different wound dressings.For relatively mature cellulose-based wound dressings,we integrate their therapeutic efficacy,functional mechanisms,clinical evidence and marketed products with typical indications.Additionally,we summarize the advantages and limitations of these polysaccharides inwound healing,while identifying future trends and challenges that should guide the rational design of polysaccharide-based wound dressings. 展开更多
关键词 Wound healing polysaccharide chitosan konjac glucomannan wound dressing cellulose
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Piceatannol-loaded self-nanoemulsifying drug delivery system accelerates wound healing in diabetic rats 认领 引用
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作者 Maha H.Jamal Rawan S.AlRashdi +4 位作者 Duaa M.Bakhshwin Basma G.Eid Ashraf B.Abdel-Naim Dalal Alfawaz Rania Magadmi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2026年第2期68-76,I0003,共9页
Objective:To evaluate the effects of a piceatannol-loaded self-nanoemulsifying drug delivery system(PIC-SNEDDS)on wound healing in diabetic rats and its mechanisms of wound healing action.Methods:Diabetes was induced ... Objective:To evaluate the effects of a piceatannol-loaded self-nanoemulsifying drug delivery system(PIC-SNEDDS)on wound healing in diabetic rats and its mechanisms of wound healing action.Methods:Diabetes was induced in rats using streptozotocin,after which full-thickness excisional wounds were created.Piceatannol was administered topically either as a raw hydrogel or formulated into a PIC-SNEDDS,which was prepared using an optimized oil-surfactant mixture and incorporated into a hydrogel for application.Wound healing activity was assessed through measurements of wound contraction,oxidative stress biomarkers,and collagen content,along with histological and immunohistochemical evaluation of inflammatory,angiogenic,and remodeling markers.Results:PIC-SNEDDS markedly enhanced diabetic wound healing by promoting epithelial regeneration,granulation tissue formation,epidermal proliferation,and keratinization.The formulation also reduced the expression of pro-inflammatory markers(interleukin-6,nuclear factor-kappa B,and tumor necrosis factor-α)while increasingα-smooth muscle actin,transforming growth factor-β1,vascular endothelial growth factor-A,and hydroxyproline levels.Additionally,it improved antioxidant status by lowering malondialdehyde levels and boosting superoxide dismutase and catalase activity,along with upregulation of COL1A1 mRNA expression.Conclusions:PIC-SNEDDS promotes the healing of diabetic wounds and exhibits anti-inflammatory,antioxidant,pro-collagen,and angiogenic properties. 展开更多
关键词 Angiogenic activities Diabetic wound healing Piceatannol Self-nanoemulsifying drug delivery system
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Does ice affect healing after muscle injury?Ask me again next century 认领 引用
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作者 Chris Bleakley 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第4期325-328,共4页
Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academic... Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academics,call for more high-quality randomized controlled trials(RCTs)to resolve the issue.This viewpoint reframes the debate around 3 key points:first,although ice produces analgesia,evidence for sustained pain relief,beyond the immediate post-treatment period. 展开更多
关键词 cryotherapy icing acute muscle injuries analgesia muscle injury randomized controlled trials ice healing randomized controlled
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A bio-healing method for underground long rock fractures with high bridging rate 认领 引用 被引量：2
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作者 Qi-Chen Dai Xiao-Hua Pan +1 位作者 Chao-Sheng Tang Bin Shi 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第2期1359-1367,共9页
One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation... One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO3precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO3precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO3precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO3precipitation.In stage II,concentrated BS is utilized to produce looser CaCO3flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO3crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance. 展开更多
关键词 Microbial-induced calcium carbonate precipitation(MICP)healing Meter-scale fracture Three-stage injection strategy High bridging rate
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Theoretical Innovation of“Natural Healing”from a Practical Perspective and Its Educational Application in Vocational Schools:Empowering Landscape School Students with the Wellness Concept to Develop Brand Construction 认领 引用
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作者 XUE Lin GU Qiang 《Journal of Landscape Research》 2026年第3期56-60,共5页
The landscaping and wellness industry is in a critical stage of standardized and high-quality development,with vast room for improvement.Based on the three major national strategies represented by Healthy China,the th... The landscaping and wellness industry is in a critical stage of standardized and high-quality development,with vast room for improvement.Based on the three major national strategies represented by Healthy China,the theoretical system of“natural healing”is innovated.Grounded in systems theory and other theoretical foundations,a practical system consisting of four elements:experiencer,healing environment,standardized activity carrier,and guide is constructed,and the ten healing pathways of intervention for“natural healing”are clarified.The integration between theory and the cultural,commercial,and sports industries,as well as the compatibility of holistic development in vocational education,are demonstrated.The“1-3-4-10”universal model has been extracted to provide theoretical support and practical solutions for industry standardization,vocational education quality improvement,and industry integration. 展开更多
关键词 Natural healing Integrated education and healing Garden health and wellness Integration of culture commerce and sports Vocational education Holistic development
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Promoting skin regeneration:research progress on hydrogel wound dressings related to scarless healing 认领 引用
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作者 Xian HU Fawei XU +5 位作者 Minxia ZHANG Yiqing CHEN Jiaqin CAI Jingjing MA Weiqiang TAN Qingqing FANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2026年第8期832-855,I0003,共24页
This review summarizes progress made in research on hydrogel wound dressings in promoting scarless skin healing.Wound healing is a complex biological process that involves four stages:hemostasis,inflammation,prolifera... This review summarizes progress made in research on hydrogel wound dressings in promoting scarless skin healing.Wound healing is a complex biological process that involves four stages:hemostasis,inflammation,proliferation,and remodeling.Scar formation is a common issue during this process,especially pathological scars such as hypertrophic scars and keloids,which severely affect aesthetics and function.In recent years,hydrogel dressings have become a research hotspot for promoting scarless healing due to their unique physicochemical and biological properties.Hydrogels promote wound healing and reduce scar formation through multiple mechanisms,including providing a moist environment,antimicrobial activity,anti-inflammatory effects,promoting tissue regeneration,and regulating the wound microenvironment.This review details the concept and mechanisms of scarless healing and explores the application of hydrogel dressings loaded with anti-scarring drugs,stem cells,and extracellular vesicles(EVs)in scarless wound healing.Additionally,it summarizes progress in research on hydrogel dressings that regulate mechanical signals and innovative multifunctional hydrogel dressings,such as photo-responsive,organic biopolymer,and nanoparticle hydrogels.These hydrogel dressings show great potential for clinical application but still face challenges such as drug delivery efficiency,biocompatibility,and long-term safety.Future research needs to further optimize the composition and functionality of hydrogels and explore their potential applications in clinical settings. 展开更多
关键词 Hydrogel Wound dressings Scarless healing Tissue regeneration Scars
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g-C3N4/ZnO nano-reinforced polysulfonate-PVA dual-network hydrogels for enhanced antibacterial ability and breathable wound healing 认领 引用
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作者 Zhenyu Liu Hizbullah Malik +7 位作者 Muhammad Bilal Khan Niazi Umer Shahzad Malik Zaib Jahan Muhammad Salman Haider Suhaib Umer Ilyas Rayed S.Alshareef Honghao Hou Dong Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期415-419,共5页
Wound healing remains a significant challenge in medical science due to the complexity of the process.Hydrogels have emerged as promising materials for wound management,yet achieving non-cytotoxicity,biodegradability,... Wound healing remains a significant challenge in medical science due to the complexity of the process.Hydrogels have emerged as promising materials for wound management,yet achieving non-cytotoxicity,biodegradability,and mechanical robustness in a single formulation continues to be a research focus.This study aims to develop polysulfonate-polyvinyl alcohol(PVA)/poly(2-acrylamido-2-methyl-1-propanesulfonic acid)(PAMPs)membranes reinforced with ZnO nanoparticles(NPs)and g-C3N4to meet these requirements.The fabricated membranes were characterized using scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),and atomic force microscopy(AFM),and were subjected to various biological evaluations including swelling ratios,water vapor transmission rates(WVTR),antibacterial activity,cytotoxicity,and in-vivo wound healing in a mouse model.The membranes exhibited mechanical strengths of 42.6 MPa and strains up to 183.35%.XRD and FTIR confirmed the successful incorporation of ZnO NPs and g-CN4,while SEM and AFM revealed a rough surface morphology conducive to cell adhesion.The membranes achieved moisture retention rates over 90%,WVTR values up to 71.66 h g-1m-2,and swelling ratios as high as 116.06%.Cytotoxicity tests demonstrated cellular viability exceeding 84.37%,and antibacterial assays showed significant inhibition zones.In vivo studies indicated an 88.26%wound healing rate within 9 days,surpassing traditional dressings and saline treatments.These results suggest that PAMPs/PVA/g-CN4/ZnO membranes are found to be highly effective for wound dressing applications,combining superior mechanical properties,biocompatibility,and enhanced healing efficacy. 展开更多
关键词 Wound healing ZnO NPs Membrane Antibacterial activity Breathability
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Advances in magnesium-incorporated polymeric scaffolds:A next-generation strategy for enhanced wound healing 认领 引用
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作者 Sundaravadhanan Lekhavadhani Sushma Babu +1 位作者 Abinaya Shanmugavadivu Nagarajan Selvamurugan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2026年第1期96-116,共21页
Wound management continues to present major clinical challenges,often necessitating therapeutic strategies that extend beyond conventional dressings,which provide only passive protection.Magnesium(Mg),a biologically i... Wound management continues to present major clinical challenges,often necessitating therapeutic strategies that extend beyond conventional dressings,which provide only passive protection.Magnesium(Mg),a biologically indispensable element,has attracted considerable attention for its multifaceted role in wound repair,including modulation of inflammatory responses,stimulation of fibroblast and keratinocyte proliferation,promotion of angiogenesis,and enhancement of collagen synthesis.However,the direct application of Mg formulations is limited by uncontrolled Mg ion(Mg2+)release,localized cytotoxicity at elevated concentrations,and inadequate mechanical stability at the wound site.To address these challenges,Mg-incorporated polymeric scaffolds have been developed as advanced delivery platforms.These systems integrate the regenerative capacity of Mg with the tunable properties of polymers,enabling controlled degradation,mechanical reinforcement,and sustained Mg2+release to establish a favorable microenvironment for tissue repair.This review critically examines the role of Mg in wound healing and the effectiveness of polymeric matrices for controlled Mg2+delivery.It further provides a comprehensive evaluation of recent advances in Mg-incorporated polymeric scaffolds,including nanofibers,hydrogels,and sponges,with emphasis on fabrication strategies,structural characteristics,and therapeutic efficacy.Key challenges,such as optimizing ion release kinetics,enhancing scaffold stability,and facilitating clinical translation,are also discussed.Collectively,this work underscores the potential of Mg-polymeric scaffolds as a next-generation platform for advanced wound care and highlights perspectives for future research and development. 展开更多
关键词 Magnesium Polymeric scaffolds Wound healing Inflammation Angiogenesis Tissue regeneration
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Computer-aided discovery of peptidyl arginine deiminase 4 inhibitors to suppress NETosis and accelerate diabetic wound healing 认领 引用
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作者 Huijuan Luo Haiyue Zuo +8 位作者 Jianzhong Zhu Juanjuan Zhao Roufen Chen Xinle Yang Fangqi Cao Ruohan Lou Xiaowu Dong Yangyang Bian Ligen Lin 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期426-430,共5页
Neutrophil extracellular traps(NETs)are a significant unfavorable factor for wound healing in diabetes.Citrullination of histone by peptidyl arginine deiminase 4(PAD4)is the prerequisite for NETs formation.Therefore,P... Neutrophil extracellular traps(NETs)are a significant unfavorable factor for wound healing in diabetes.Citrullination of histone by peptidyl arginine deiminase 4(PAD4)is the prerequisite for NETs formation.Therefore,PAD4 inhibitors are a promising NETs-targeting strategy to accelerate diabetic wound healing.Herein,a virtual screening workflow incorporating molecular docking and molecular dynamics was performed on a library of U.S.Food and Drug Administration(FDA)-approved drugs,resulting in the identification of gliquidone as a new PAD4 inhibitor.Gliquidone binds directly to PAD4,inhibits its activity,and interrupts NETs formation in neutrophils,which in turn rescues functional impairment in fibroblasts.Furthermore,in streptozotocin-induced diabetic mice,gliquidone accelerates wound healing.Taken together,gliquidone was successfully identified as a new PAD4 inhibitor through a computer-aided virtual screening pipeline,which might be a therapeutic agent against diabetic foot ulcers. 展开更多
关键词 Peptidyl arginine deiminase 4 Molecular docking and molecular dynamics Neutrophil extracellular traps Gliquidone Diabetic wound healing
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Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing 认领 引用
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作者 Mingjian Huang Abhinav Reddy Balu +2 位作者 Kristin Happ Molitoris Akshay Bareja Gurpreet Singh Baht 《Bone Research》 SCIE CAS CSCD 2026年第1期210-221,共12页
Advanced age impairs bone fracture healing;the underlying mechanism of this phenomenon remains unknown.We determined that apolipoprotein E(ApoE)increases with age and causes poor fracture healing.After deletion of hep... Advanced age impairs bone fracture healing;the underlying mechanism of this phenomenon remains unknown.We determined that apolipoprotein E(ApoE)increases with age and causes poor fracture healing.After deletion of hepatic ApoE expression(ΔApoE),24-month-oldΔApoE mice displayed a 95%reduction in circulating ApoE levels and significantly improved fracture healing.ApoE treatment of aged BMSCs inhibited osteoblast differentiation in tissue culture models;RNA-seq,Western blot,immunofluorescence,and RT-PCR analyses indicated that the Wnt/β-catenin pathway is the target of this inhibition.Indeed,we showed that ApoE had no effect on cultures with stabilizedβ-catenin levels.Next,we determined that Lrp4 serves as the osteoblast cell surface receptor to ApoE,as expression of Lrp4 is required in ApoE-based inhibition of Wnt/β-catenin signaling and osteoblast differentiation.Importantly,we validated this ApoE-Lrp4-Wnt/β-catenin molecular mechanism in human osteoblast differentiation.Finally,we identified an ApoE-neutralizing antibody(NAb)and used it to treat aged,wildtype mice 3 days after fracture surgery resulting in fracture calluses with 35%more bone deposition.Our work here identifies novel liver-to-bone cross-talk and a noninvasive,translatable therapeutic intervention for aged bone regeneration. 展开更多
关键词 hepatic apolipoprotein E Wnt catenin pathway deletion hepatic apoe expression apoe month old apoe aged bmscs bone fracture healing LRP apolipoprotein E neutralizing antibody tissue culture modelsrna seqwestern blotimmunofluorescenceand
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