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Fast step heterodyne light-induced thermoelastic spectroscopy gas sensing based on a quartz tuning fork with high-frequency of 100 kHz 认领 引用 被引量：4
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作者 Yuanzhi Wang Ying He +4 位作者 Shunda Qiao Xiaonan Liu Chu Zhang Xiaoming Duan Yufei Ma 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2026年第1期36-48,共13页
In this paper,a fast step heterodyne light-induced thermoelastic spectroscopy(SH-LITES)sensor using a high-frequency quartz tuning fork(QTF)with resonant frequency of~100 kHz is reported for the first time.The theoret... In this paper,a fast step heterodyne light-induced thermoelastic spectroscopy(SH-LITES)sensor using a high-frequency quartz tuning fork(QTF)with resonant frequency of~100 kHz is reported for the first time.The theoretical principle of heterodyne LITES(H-LITES)signal generation is analyzed firstly,and an acetylene(C2H2)H-LITES sensor is established to verify its performance.Experimental comparisons between the high-frequency QTF and a standard commercial QTF with resonant frequency of~32.768 kHz reveal that the high-frequency QTF exhibits a tenfold faster response time.Specifically,the H-LITES sensor with this QTF achieves a 33 ms measurement cycle,90%shorter than commercial counterparts.Furthermore,The SH-LITES technique is proposed to further shorten the scanning time to 15 ms,which achieves the shortest LITES measurement time known to date.To demonstrate its advantages in dynamic gas detection,an H2O-LITES system integrating both QTF types is constructed for real-time monitoring of H2O concentration during different respiration patterns.Comparative measurements show that the SH-LITES more accurately captures dynamic H2O concentration fluctuations during respiration,outperforming the commercial QTF-based H-LITES sensor in rapid response scenarios. 展开更多
关键词 fast heterodyne light-induced thermoelastic spectroscopy(H-LITES) high-frequency quartz tuning fork(QTF) step heterodyne light-induced thermoelastic spectroscopy(SH-LITES) respiration detection
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High-Frequency Signal Recovery via the Constraint of Refl ection Structure in f-x Domain 认领 引用
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作者 Sun Chong Lan Nan-ying +5 位作者 Zheng Duo-ming Tian Hao-nan Jian Shi-kai Yang Lang Ran Zhi-fang Liu Rui-dong 《Applied Geophysics》 SCIE CSCD 2026年第2期765-773,871,872,共9页
The intrinsic absorption of seismic waves in viscoelastic media attenuates high-frequency components,thereby reducing resolution in thin-layer structures.Although deconvolution is the most common approach to resolutio... The intrinsic absorption of seismic waves in viscoelastic media attenuates high-frequency components,thereby reducing resolution in thin-layer structures.Although deconvolution is the most common approach to resolution enhancement,conventional algorithms amplify both signal and noise,degrading the signal-to-noise ratio(SNR).To address this,we introduce a structure-constrained method for high-frequency recovery in the frequency–space(f–x)domain.First,we exploit the statistical predictability of seismic records in the f–x domain by fitting an autoregressive–moving-average(ARMA)model,from which we derive a prediction operator and its associated prediction-error fi lter(PEF).This operator characterizes spatial coherence in seismic signals and distinguishes seismic signals from random noise.We then embed this operator as a structural constraint within a multichannel sparse-inversion framework.By enforcing spatially adaptive regularization guided by predicted structural trends,our approach suppresses noise amplifi cation during highfrequency recovery and enhances the fi delity of the reconstructed signal.Extensive tests on both synthetic and fi eld datasets demonstrate that the proposed method signifi cantly improves seismic resolution while preserving a high SNR. 展开更多
关键词 Refl ection structures Resolution High-frequency recovery Sparse inversion
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Effect of high-frequency microseismicity on shear strength of interlayer structural planes of bedding rock landslides 认领 引用
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作者 Shan Dong Xi Hu +2 位作者 Tingting Shi Qihua Zhang Zhijie Mai 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第3期1719-1735,共17页
Water storage in the Three Gorges Reservoir in China has increased the regional microseismicity.Bedding-rock landslides,one of the most common slope structures in the Three Gorges Reservoir,are highly prone to sliding... Water storage in the Three Gorges Reservoir in China has increased the regional microseismicity.Bedding-rock landslides,one of the most common slope structures in the Three Gorges Reservoir,are highly prone to sliding under seismic loading.Existing research primarily focuses on the stability of bedding rock landslides under strong earthquakes,while studies on the cumulative damage and long-term stability of bedding rock landslides under high-frequency microseismicity remain immature.In this study,we considered bedding rock landslides under high-frequency microseismicity in the Three Gorges Reservoir area as the research subject and equivalent microseismicity as pre-peak cyclic loading.First,we analyzed the shear strength deterioration of rock mass structural planes under pre-peak cyclic loading conditions and found that the deformation and failure of structural planes involve contact and damage effects.The shear strength of the rock mass structural planes under pre-peak cyclic loading conditions is affected by the confining pressure,loading rate,loading amplitude,and number of loading cycles.Among these factors,the shear strength of the structural planes was the most sensitive to the number of loading cycles.As the number of cycles increased,the rock mass structural planes underwent three stages:stress adjustment(increase in shear strength),fatigue damage(gradual decrease in shear strength),and structural failure(rapid decrease in shear strength).The stability of bedding rock landslides under high-frequency microseismicity was analyzed,revealing that the stability of bedding rock landslides under high-frequency microseismicity can be divided into three stages:short-term enhancement,gradual degradation,and rapid deterioration,exhibiting characteristics of gradual and sudden changes. 展开更多
关键词 High-frequency microseismicity Rock mass structural plane Shear strength deterioration Bedding rock landslides Stability analysis
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High-frequency irreversible electroporation synergizes with PD-1/PDL1 inhibitor BMS-1 and TLR7/8 agonist R848 to potentiate liver cancer antitumor immunity 认领 引用
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作者 Shi-Ming Huang Xiao-Bo Zhang +10 位作者 Jing Li Guo-Hui Zhang Xiao Zhang Ying-Tian Wei Hui Sun Li Ma Zhen-Jun Wang Di-Xiao Yao Hong-Jian Shi Ti Wang Yue-Yong Xiao 《World Journal of Gastroenterology》 SCIE CAS 2026年第15期102-123,共22页
BACKGROUND High-frequency irreversible electroporation(H-FIRE),a second-generation tumor ablation therapy,has demonstrated efficacy and safety in treating liver cancer.However,its clinical application is hindered by t... BACKGROUND High-frequency irreversible electroporation(H-FIRE),a second-generation tumor ablation therapy,has demonstrated efficacy and safety in treating liver cancer.However,its clinical application is hindered by the risk of residual disease and metastasis resulting from incomplete ablation,while H-FIRE’s inherent capacity to induce immunogenic cell death(ICD)provides a potential direction for optimizing its efficacy.AIM To leverage H-FIRE’s ICD capacity,and investigate the efficacy and safety of H-FIRE combined with immunotherapy in the treatment of liver cancer.METHODS A murine subcutaneous hepatocellular carcinoma model was established using hepatoma 22 cells.Mice were randomized into eight groups:Control,BMS-1,R848,BMS-1+R848,H-FIRE,H-FIRE+BMS-1,H-FIRE+R848,and H-FIRE+BMS-1+R848.Treatments comprised:Intraperitoneal BMS-1 and intratumoral R848 administered every 2 days(4 total doses);H-FIRE ablation performed once when tumors reached 7-8 mm in long diameter.Efficacy was assessed by monitoring survival,primary tumor volume,primary tumor cell proliferation and damageassociated molecular patterns expression,immune microenvironment alterations in primary tumors and spleens,distant secondary tumor apoptosis,and treatment safety.RESULTS H-FIRE robustly induced ICD in primary liver tumors.Notably,the triple-combination therapy(H-FIRE+BMS-1+R848)exerted the most potent antitumor efficacy:It significantly reduced primary tumor burden relative to all other monotherapy or dual-combination groups,with a mean tumor volume of 305.3±35.0 mm3 in the triplecombination group.This therapeutic benefit was further confirmed by markedly extended overall survival,with median survival times of 17,24.5,25,28.5,28.5,33.5,37.5,and 53 days,respectively.Mechanistically,the triplecombination strategy was accompanied by enhanced tumor cell apoptosis and suppressed cell proliferation,underscoring its multi-faceted antitumor effects.In primary tumors and spleens,this combination markedly increased proportions of CD3+CD4+T cells,CD3+CD8+T cells,CD11c+CD80+CD86+dendritic cells,F4/80+CD11b+CD86+M1 macrophages,and the M1/M2 macrophage ratio.Conversely,it reduced proportions of CD4+CD25+FOXP3+regulatory T cells and F4/80+CD11b+CD206+M2 macrophages,with no significant toxicity observed.Furthermore,the triple therapy effectively promoted apoptosis and inhibited growth in distant secondary tumors.CONCLUSION The triple therapy synergistically reverses local and systemic immune tolerance,eliciting robust anti-tumor immunity.This strategy not only effectively inhibits primary and secondary tumor progression but also exhibits favorable safety,underscoring its potential as a novel combinatorial cancer treatment. 展开更多
关键词 Liver cancer High-frequency irreversible electroporation Programmed death-1/programmed death-ligand 1 inhibitor Toll-like receptor 7/8 agonist Antitumor immunity
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Genetic diversity and population structure of the Fujian oyster Crassostrea angulata revealed by mitochondrial COI gene and nuclear gene ITS2 sequences 认领 引用
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作者 Shiqi YU Ziqiang HAN Huayong QUE 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第1期419-432,共14页
The Fujian oyster(Crassostrea angulata) is an economically significant shellfish species distributed mainly along the Fujian coast, Southeast China. However, its genetic diversity and structure remain unclear. The mai... The Fujian oyster(Crassostrea angulata) is an economically significant shellfish species distributed mainly along the Fujian coast, Southeast China. However, its genetic diversity and structure remain unclear. The main distribution area of the C. angulata is located in Fujian, South China. In total, 420 C. angulata were collected from 14 natural habitats(populations) along the Fujian coast, and their genetic diversity and structure were analyzed in the mitochondrial COI and nuclear gene ITS2 sequences. Results reveal that all the 14 populations of C. angulata exhibited high levels of genetic diversity, with a total of 57(haplotype diversity: 0.811±0.016) and 124(haplotype diversity: 0.912±0.007) haplotypes revealed by COI and ITS2, respectively. Notably, significant intermediate level of genetic differentiations between the Ningde Zhujiang(ZJ) population(FS T by COI: 0.035–0.142, P<0.05;FS T by ITS2: 0.078–0.123, P<0.05) with other populations were observed for the first time, which is also supported by the results of molecular variance analysis(FC T by COI: 0.105, P<0.05;FC T by ITS2: 0.086, P<0.05) and the clustering of the ZJ population into distinct branches in the interpopulation genetic differentiation tree. Furthermore, the evolutionary tree and haplotype network analyses do not support the formation of a clear geographical genealogical structure among these 14 populations. In addition, the population dynamics analysis suggests that the C. angulata may have undergone expansion during the third ice age of the Pleistocene. These results provide a reference for the preservation and further genetic improvement of C. angulata. 展开更多
关键词 Crassostrea angulata genetic diversity population structure mitochondrial COⅠgene nuclear gene ITS2 sequence
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Higher-Order Expansions of Powered Order Statistics of Maxwell Sequences 认领 引用
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作者 HUANG Jian-wen LIU Xin-ling +1 位作者 JIA Jin-ping WANG Run-ke 《Chinese Quarterly Journal of Mathematics》 2026年第2期162-173,共12页
Under the optimal norming constants, this paper studies the higher-order expansions of the distributions and densities of the powered order statistics of Maxwell sequence. As auxiliary results, the corresponding conve... Under the optimal norming constants, this paper studies the higher-order expansions of the distributions and densities of the powered order statistics of Maxwell sequence. As auxiliary results, the corresponding convergence rates are obtained. The results show that the convergence rates of distributions and densities of normalized power order statistics are related to power index in principle. Finally, we compared the accuracy of each approximations with its true values through numerical experiments. 展开更多
关键词 Maxwell sequences Powered order statistics Higher-order expansion Convergence rate
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High-frequency emphasized neural network reconstruction method for in situ synchrotron radiation ultrafast computed tomography characterization 认领 引用
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作者 Jing-Wei Li Yu Xiao +3 位作者 Yong-Cun Li Xiao-Fang Hu Guo-Hao Du Feng Xu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2026年第3期5-17,共13页
There is a contradiction between the evolution rate of materials and the time resolution of SR-CT characterization in the in situ synchrotron radiation computed tomography(SR-CT)characterization of ultrafast evolution... There is a contradiction between the evolution rate of materials and the time resolution of SR-CT characterization in the in situ synchrotron radiation computed tomography(SR-CT)characterization of ultrafast evolution process.The sampling strategy of the ultra-sparse angle is an effective method for improving time resolution.Accurate reconstruction under sparse sampling conditions has always been a bottleneck problem.In recent years,convolutional neural networks have shown outstanding advantages in sparse-angle CT reconstruction given the development of deep learning.However,existing ideas did not consider the expression of high-frequency details in neural networks,limiting their application in accurate SR-CT characterization.A novel high-frequency information-constrained deep learning network(HFIC-Net)is proposed in response to this problem.Additional high-frequency information constraints are added to improve the accuracy of the reconstruction results.Further,a series of numerical reconstruction experiments are conducted to verify this new method,and the results indicate that the reconstruction results of HFIC-Net method effectively improve reconstruction quality.This new method uses only eight-angle projections to achieve the reconstruction effect of the filtered backprojection method(FBP)method in 360 projections.The results of the HFIC-Net method demonstrate clear boundaries and accurate detailed structures,correcting the misinformation caused by using other methods.For quantitative evaluation,the SSIM used to evaluate image structure similarity is increased from 0.1951,0.9212,and 0.9308 for FBP,FBP-Conv,and DDC-Net,respectively,to 0.9620 for HFIC-Net.Finally,the results of actual SR-CT experimental data indicate that the new method can suppress artifacts and achieve accurate reconstruction,and it is suitable for the in situ SR-CT accurate characterization of ultxafast evolution process. 展开更多
关键词 Accurate SR-CT characterization CT reconstruction Sparse-angle CT reconstruction problem High-frequency information constrained Deep learning
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Neural boundary shape functions in physics-informed neural networks for discontinuous and high-frequency problems 认领 引用
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作者 P.T.NGUYEN K.A.LUONG J.H.LEE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第2期423-442,共20页
Physics-informed neural networks(PINNs)have been shown as powerful tools for solving partial differential equations(PDEs)by embedding physical laws into the network training.Despite their remarkable results,complicate... Physics-informed neural networks(PINNs)have been shown as powerful tools for solving partial differential equations(PDEs)by embedding physical laws into the network training.Despite their remarkable results,complicated problems such as irregular boundary conditions(BCs)and discontinuous or high-frequency behaviors remain persistent challenges for PINNs.For these reasons,we propose a novel two-phase framework,where a neural network is first trained to represent shape functions that can capture the irregularity of BCs in the first phase,and then these neural network-based shape functions are used to construct boundary shape functions(BSFs)that exactly satisfy both essential and natural BCs in PINNs in the second phase.This scheme is integrated into both the strong-form and energy PINN approaches,thereby improving the quality of solution prediction in the cases of irregular BCs.In addition,this study examines the benefits and limitations of these approaches in handling discontinuous and high-frequency problems.Overall,our method offers a unified and flexible solution framework that addresses key limitations of existing PINN methods with higher accuracy and stability for general PDE problems in solid mechanics. 展开更多
关键词 physics-informed neural network(PINN) boundary shape function(BSF) strong-form approach energy approach discontinuity high-frequency problem
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Seismic Response of Offshore Reinforced Concrete Bridges Under Main-Aftershock Sequences 认领 引用
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作者 CAO Jing LI Yue +1 位作者 ZHANG Changyong LI Chong 《吉首大学学报（自然科学版）》 CAS 2026年第2期62-71,共10页
To investigate the seismic response evolution of offshore bridges under the coupled effects of main-aftershock sequences and chloride-induced erosion,a time-dependent damage finite element model of a three-span,three-... To investigate the seismic response evolution of offshore bridges under the coupled effects of main-aftershock sequences and chloride-induced erosion,a time-dependent damage finite element model of a three-span,three-column simply supported bridge was established based on energy dissipation theory and static pushover analysis.Seismic time-history analysis was conducted to obtain key response indicators,including the maximum displacement and residual displacement at the pier top,as well as the proportion of cumulative hysteretic energy generated at the pier bottom during aftershocks.The results show that structural durability degradation significantly affected the seismic responses:under the same seismic excitation,the maximum pier-top displacement of long-term service bridges increased by at least 10%,with a maximum increase of up to 43%,compared with newly built bridges.When subjected to high-intensity earthquakes,the residual displacement at the pier top continuously increased with service time,rising by 66%,121%,and 163%after 50,75,and 100 a of service,respectively,compared with new bridges.Aftershocks induced noticeable cumulative damage at critical locations such as the pier bottom,with the cumulative hysteretic energy accounting for an average of 14.08%of the total energy dissipation during the main-aftershock sequence,reaching a maximum of 25.3%.Therefore,it is recommended that both the energy contribution of aftershocks and the effect of durability degradation be considered in the seismic design of offshore bridges. 展开更多
关键词 main-aftershock sequences chloride ion erosion simply-supported bridge maximum displacement residual displacement hysteresis curve
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Effects of welding sequences and filler metals on microstructure and mechanical properties of N08825/L360 nickel-based alloy clad plate welded joints 认领 引用
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作者 ZHU Min 《Baosteel Technical Research》 CAS 2026年第2期33-46,共14页
Nickel-based alloy clad plate(NACP)is a promising composite structural material owing to its excellent mechanical and corrosion-resistant properties,as well as its low cost.However,the development of welding technolog... Nickel-based alloy clad plate(NACP)is a promising composite structural material owing to its excellent mechanical and corrosion-resistant properties,as well as its low cost.However,the development of welding technology for NACP has lagged behind.Herein,N08825/L360 NACP was used as the model material,and welded joints were prepared using tungsten inert gas welding to investigate the effects of different welding sequences and filler metals on the micro structure and mechanical properties of joints.The results showed that weld seams filled with mixed filler metals under the post-flyer welding seam welding sequence exhibited a uniform micro structure,and the joints performed well in tensile,bending,and impact tests.For joints filled with mixed filler metals under the post-base welding seam sequence(P-BWS)satisfactory face-bending,root-bending,and tensile properties were achieved;however,cracks formed in the side-bending specimens,and the impact toughness decreased greatly.Micro structural analysis shows that the deterioration in weld toughness is attributable to two factors:severe dimensional embrittlement and micro structural embrittlement,both caused by the formation of hardened welds in the welding seam.Under the P-BWS,using only nickel-based alloy filler metals effectively prevents the deterioration of the micro structure and properties of welding seams. 展开更多
关键词 N08825/L360 nickel-based alloy clad plate welding sequence welding filler metals microstructure mechanical property
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High-frequency gradient 1-3 piezoelectric composites and ultrasonic transducer for medical imaging 认领 引用
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作者 Hongchao Li Ziqi Li +9 位作者 Na Huang Mingze Sun Xiandi Jin Jiajun Chen Wei Chu Qi Zhou Wenwu Cao Jie Xu Chang Peng Xiaohua Jian 《Journal of Materiomics》 SCIE EI CSCD 2026年第5期81-90,共10页
High-frequency ultrasonic transducers are essential for high-resolution clinical diagnostics or industrial non-destructive testing.While 1-3 piezoelectric composites offer superior acoustic impedance matching and elec... High-frequency ultrasonic transducers are essential for high-resolution clinical diagnostics or industrial non-destructive testing.While 1-3 piezoelectric composites offer superior acoustic impedance matching and electromechanical coupling efficiency compared to traditional bulk ceramics,their high-frequency performance is often compromised by periodic lateral vibration modes.These parasitic res-onances significantly degrade sensitivity,bandwidth,and imaging quality.To overcome this limitation without increasing manufacturing complexity,this study proposes a gradient-structure piezoelectric composite that uses a non-periodic distribution of piezoelectric pillars to physically disrupts the phase coherence of lateral standing waves.The structural parameters of the piezocomposite were optimized and validated using theoretical derivation and Finite Element Analysis(FEA).Compared to conventional designs,our fabricated high-frequency gradient composite transducer showed significantly improved 6 dB bandwidth(73%),electromechanical coupling coefficient(0.74),and pulse-echo sensitivity.Furthermore,the imaging experiments performed on phantom,tungsten wire and ex vivo tissues indicated that the gradient transducer achieves superior resolution and Contrast-to-Noise Ratio(CNR).These findings indicate that the gradient structure design provides a practical solution to current performance bottlenecks of high-frequency transducers,offering substantial theoretical significance and broad application potential in precision medical ultrasound imaging. 展开更多
关键词 Piezoelectric composites Gradient structure Lateral vibration mode High-frequency ultrasonic transducer Medical ultrasound imaging
High-Frequency Sequence Stratigraphy and Fine-Scale Reservoir Characterization of the Devonian Sandstone, Donghe Formation, North Uplift of the Tarim Basin 认领 引用
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作者 WANG Ziyuan LIU Li +2 位作者 PAN Mao SHI Yongmin XIONG Fengyang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2018年第5期1917-1933,共17页
The Devonian Donghe Sandstone complex in North Uplift of the Tarim Basin comprises of a series of diachronous sandy intervals deposited from the Late Devonian to Early Mississippian. They are constrained by a Late Dev... The Devonian Donghe Sandstone complex in North Uplift of the Tarim Basin comprises of a series of diachronous sandy intervals deposited from the Late Devonian to Early Mississippian. They are constrained by a Late Devonian to Early Pennsylvanian 2 nd-order supersequence and can be subdivided into five 3 rd-order sequences, namely, S1, S2, S3, S4, and S5, from the oldest to youngest. Cores from four wells, 40 wireline logs, 410 thin sections, and porosity and permeability data from 639 spots from four wells were used to study the sediment provenance, build up the sequence-stratigraphic model of S5, and characterize the reservoirs at a feet scale. Detrital modes of sandstone from point counting indicate that Donghe Sandstone is directly sourced from recycled orogeny. The low content of feldspar and volcanic rock fragments suggests that Donghe Sandstone is recycled from sediment with a cratonic ultimate source. 1 D and 2 D chronostratigraphic correlation shows that at least 12 4 th-order highfrequency sequences（HFSs）, from the oldest HFS1 to the youngest HFS12, can be recognized in S5. Each HFS is characterized by a general trend of shallowing-upward facies assemblage. Sequence boundaries were defined at where regionally correlatable deep-water facies overlaying shallow-water facies. There is a general shallowing-upward trend in the S5 3 rd-order sequence, characterized by a systematically increasing proportion of shallow-water facies（foreshore and upper shoreface）, and a decreasing proportion of deep facies（offshore transition and lower shoreface）. The shallowing-upward trend within both 3 rd-and 4 th-order sequences is resulted from a combined effect of eustatic sea-level change, tectonic activity, and sediment supply. The sequence-stratigraphic model of Donghe Sandstone S5 is similar to the rift-basin sequence-stratigraphic model. Sweet spots were defined as porosity 〉15% and permeability 〉100 md intervals, and their distribution and lateral continuity were investigated. HFS is one of the primary controls on the distribution of sweet spots distribution and can be used to guide hydrocarbon exploration. 展开更多
关键词 high-frequency sequences shoreline systems reservoir heterogeneity Tarim Basin
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High-Frequency Trading:Deception and Consequences 认领 引用 被引量：1
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作者 Viktoria Dalko Michael H.Wang 《Journal of Modern Accounting and Auditing》 2018年第5期271-280,共10页
This commentary is based on the work of Cooper,Davis,and Van Vliet(2016)and the commentary focuses on what problem high-frequency trading poses.It lists key literature on high-frequency trading that is missing and poi... This commentary is based on the work of Cooper,Davis,and Van Vliet(2016)and the commentary focuses on what problem high-frequency trading poses.It lists key literature on high-frequency trading that is missing and points out that the poker analogy to defend deception in financial markets is weak and misleading.The article elaborates on the negative impact created by spoofing and quote stuffing,the two typical deceptive practices used by high-frequency traders.The recent regulations regarding high-frequency trading,in response to the“Flash Crash”of 2010,are preventive,computerized and more effective.They reflect ethical requirements to maintain fair and stable financial markets. 展开更多
关键词 high-frequency trading deception volatility instability ethics regulation
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High efficiency of thalassemia prevention by next-generation sequencing:a real-world cohort study in two centers of China 认领 引用 被引量：3
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作者 Jinman Zhang Wenqian Zhang +18 位作者 Haoqing Zhang Aiqi Cai Caiyun Li Ling Liu Jufang Tan Yang Yang Wen Yuan Jing He Shiping Chen Yingli Cao Yan Zhang Jie Zhang Rui Zhou Shuai Hou Dongqun Huang Danjing Chen Zhiyu Peng Dongzhu Lei Baosheng Zhu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第1期87-96,共10页
The occurrence of severe thalassemia,an inherited blood disorder that is either blood-transfusiondependent or fatal,can be mitigated through carrier screening.Here,we aim to evaluate the effectiveness and outcomes of ... The occurrence of severe thalassemia,an inherited blood disorder that is either blood-transfusiondependent or fatal,can be mitigated through carrier screening.Here,we aim to evaluate the effectiveness and outcomes of pre-conceptional and early pregnancy screening initiatives for severe thalassemia prevention in a diverse population of 28,043 women.Using next-generation sequencing(NGS),we identify 4,226(15.07%)thalassemia carriers across 29 ethnic groups and categorize them into high-(0.75%),low-(25.86%),and unknown-risk(69.19%)groups based on their spouses'screening results.Post-screening follow-up reveals 59 fetuses with severe thalassemia exclusively in high-risk couples,underscoring the efficacy of risk classification.Among 25,053 live births over 6 months of age,two severe thalassemia infants were born to unknown-risk couples,which was attributed to incomplete screening and late NGS-based testing for a rare variant.Notably,64 rare variants are identified in 287 individuals,highlighting the genetic heterogeneity of thalassemia.We also observe that migrant flow significantly impacts carrier rates,with 93.90%of migrants to Chenzhou originating from high-prevalence regions in southern China.Our study demonstrates that NGS-based screening during pre-conception and early pregnancy is effective for severe thalassemia prevention,emphasizing the need for continuous screening efforts in areas with high and underestimated prevalence. 展开更多
关键词 Thalassemia Carrier screening Next generation sequencing Rare thalassemia Clinical effectiveness Blood-transfusion-dependent
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A novel logging method for detecting highly resistive formations in oil-based mud using high-frequency electrodes 认领 引用
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作者 Kang-Kang Wu Lei Wang +1 位作者 Shao-Gui Deng Xue-Wen Kou 《Petroleum Science》 SCIE EI CAS CSCD 2025年第5期1946-1958,共13页
The oil-based mud(OBM) borehole measurement environment presents significant limitations on the application of existing electrical logging instruments in high-resistance formations. In this paper, we propose a novel l... The oil-based mud(OBM) borehole measurement environment presents significant limitations on the application of existing electrical logging instruments in high-resistance formations. In this paper, we propose a novel logging method for detection of high-resistance formations in OBM using highfrequency electrodes. The method addresses the issue of shallow depth of investigation(DOI) in existing electrical logging instruments, while simultaneously ensuring the vertical resolution. Based on the principle of current continuity, the total impedance of the loop is obtained by equating the measurement loop to the series form of a capacitively coupled circuit. and its validity is verified in a homogeneous formation model and a radial two-layer formation model with a mud standoff. Then, the instrument operating frequency and electrode system parameters were preferentially determined by numerical simulation, and the effect of mud gap on impedance measurement was investigated. Subsequently, the DOI of the instrument was investigated utilizing the pseudo-geometric factor defined by the real part of impedance. It was determined that the detection depth of the instrument is 8.74 cm, while the effective vertical resolution was not less than 2 cm. Finally, a focused high-frequency electrode-type instrument was designed by introducing a pair of focused electrodes, which effectively enhanced the DOI of the instrument and was successfully deployed in the Oklahoma formation model. The simulation results demonstrate that the novel method can achieve a detection depth of 17.40 cm in highly-resistive formations drilling with OBM, which is approximately twice the depth of detection of the existing oil-based mud microimager instruments. Furthermore, its effective vertical resolution remains at or above 2 cm,which is comparable to the resolution of the existing OBM electrical logging instrument. 展开更多
关键词 Oil-based mud Highly-resistive High-frequency electrode Bulking electrode Depth of investigation
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High-frequency enhanced ultrafast compressed active photography 认领 引用
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作者 Yizhao Meng Yu Lu +5 位作者 Pengfei Zhang Yi Liu Fei Yin Lin Kai Qing Yang Feng Chen 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2025年第1期32-43,共12页
Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the ra... Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame reconstruction.Here,a high-frequency enhanced compressed active photography(H-CAP)is proposed.By uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling mode.This sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image enhanced.The superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,respectively.We applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames. 展开更多
关键词 ultrafast compressed imaging high-frequency enhanced sampling spectral-temporal transform transient processes high-fidelity reconstruction
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Exploration of salience theory to deep learning:evidence from Chinese new energy market high-frequency trading 认领 引用
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作者 Qing Zhu Jinhong Du Yuze Li 《Data Science and Management》 EI CSCD 2025年第3期296-309,共14页
Salience theory has been proposed as a new stock trading strategy.To assess the validity of this proposal,a complex decision trading system was constructed based on salience theory,a variational mode decomposition(VMD... Salience theory has been proposed as a new stock trading strategy.To assess the validity of this proposal,a complex decision trading system was constructed based on salience theory,a variational mode decomposition(VMD)model,a bidirectional gated recurrent unit(BiGRU)model,and high-frequency trading.The system selected 30 Chinese new energy concept stocks,ranked the stocks using salience theory,and selected the top and bottom three stocks for two portfolios.Twelve stages were established,following which the VMD and BiGRU models were applied to the predictions.The final predicted annualized returns for the high ST(salience theory value)group A(GA)and low ST group B(GB)were 194.06%and 165.88%,respectively.This finding validates the powerful utility of salience theory and deep learning to analyze the Chinese new energy market.Moreover,it explains the theoretical practicality issues that the short selling restriction is the essential reason,or even perhaps the only reason,that leads to the strength of salience theory. 展开更多
关键词 Salience theory Portfolio Decision trading system High-frequency trading Deep learning
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Selection and application of wavelet transform in high-frequency sequence stratigraphy analysis of coarse-grained sediment in rift basin 认领 引用 被引量：5
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作者 Ling Li Zhi-Zhang Wang +4 位作者 Shun-De Yin Wei-Fang Wang Zhi-Chao Yu Wen-Tian Fan Zhi-Heng Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第5期3016-3028,共13页
Wavelet transformation is a widely used method in high-frequency sequence stratigraphic analysis.However, the application is problematic since different wavelets always return the same sequence analysis results. To ad... Wavelet transformation is a widely used method in high-frequency sequence stratigraphic analysis.However, the application is problematic since different wavelets always return the same sequence analysis results. To address this issue, we applied five commonly used wavelets to theoretical sequence models to document some application criteria. Five gradual scale-change sequence models were simplified from the glutenite succession deposition by gravity flows to form the fining-upwards cycle sequences(FUCS) and coarsening-upwards cycle sequences(CUCS). After conducting theoretical sequence model tests, the optimal wavelet(sym4) was selected and successfully used with actual data to identify the sequence boundaries. We also proposed a new method to optimize the scale of continuous wavelet transformation(CWT) for sequence boundary determination. We found that the balloon-like marks in scalograms of db4, sym4, and coif4 wavelet determine, respectively, the fourth-order sequence boundary, the thick succession sequence boundaries in FUCS, and the thick succession sequence in FUCS and CUCS. Comparing the sequence identification results shows that the asymmetric wavelets had an advantage in high-frequency sequence boundary determination and sedimentary cycle discrimination through the amplitude trend of the coefficient, in which the sym4 wavelet is the most effective. In conclusion, the asymmetry of wavelets is the first selection principle, of which asymmetric wavelets are more sensitive to sediment deposition by flood flows. The match of the wavelet between the sequence is the second selection principle, in which the correlation of time-frequency impacts the accuracy of sequence surface localization. However, the waveform of the wavelet is a visual and abstract parameter for sequence boundary detection. The appropriate wavelet for lacustrine sequence analysis is the asymmetric wavelet with a weak number of side lobes. The depositional flows, depositional process,and autogenic are three sedimentary factors that influence the sequence analysis results. 展开更多
关键词 Wavelet analysis High-resolution sequence Sedimentary cyclicity Asymmetric wavelets
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 认领 引用 被引量：2
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作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages clodronate hypoxia ischemia-reperfusion ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
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Fault Distance EstimationMethod for DC Distribution Networks Based on Sparse Measurement of High-Frequency Electrical Quantities 认领 引用
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作者 He Wang Shiqiang Li +1 位作者 Yiqi Liu Jing Bian 《Energy Engineering》 EI 2025年第11期4497-4521,共25页
With the evolution of DC distribution networks from traditional radial topologies to more complex multi-branch structures,the number of measurement points supporting synchronous communication remains relatively limite... With the evolution of DC distribution networks from traditional radial topologies to more complex multi-branch structures,the number of measurement points supporting synchronous communication remains relatively limited.This poses challenges for conventional fault distance estimation methods,which are often tailored to simple topologies and are thus difficult to apply to large-scale,multi-node DC networks.To address this,a fault distance estimation method based on sparse measurement of high-frequency electrical quantities is proposed in this paper.First,a preliminary fault line identification model based on compressed sensing is constructed to effectively narrow the fault search range and improve localization efficiency.Then,leveraging the high-frequency impedance characteristics and the voltage-current relationship of electrical quantities,a fault distance estimation approach based on high-frequency measurements from both ends of a line is designed.This enables accurate distance estimation even when the measurement devices are not directly placed at both ends of the faulted line,overcoming the dependence on specific sensor placement inherent in traditional methods.Finally,to further enhance accuracy,an optimization model based on minimizing the high-frequency voltage error at the fault point is introduced to reduce estimation error.Simulation results demonstrate that the proposed method achieves a fault distance estimation error of less than 1%under normal conditions,and maintains good performance even under adverse scenarios. 展开更多
关键词 DC distribution network fault location compressed sensing fault distance estimation high-frequency electrical quantities
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