Purpose-With the continuous expansion of railway hubs,increasing functional complexity and growing capacity constraints,the coordinated and efficient utilization of transportation resources-such as stations,lines and ...Purpose-With the continuous expansion of railway hubs,increasing functional complexity and growing capacity constraints,the coordinated and efficient utilization of transportation resources-such as stations,lines and maintenance facilities-has become a critical issue for improving hub operational efficiency.This study focuses on the division of functions within railway hubs that incorporate shared stations operating under mixed high-speed and conventional train services.Design/methodology/approach-An optimization model for hub functional allocation is developed to achieve efficient resource utilization in hubs containing mixed-operation stations.A node-arc network representation combined with an improved multi-commodity flow model is employed,taking train dwell and operation time within the hub as the optimization objective.A case study is conducted to derive optimized solutions,followed by both qualitative and quantitative analyses.Findings-The results indicate that optimizing train operation routes and station assignments within the hub can effectively reduce the total occupation time of train flows and significantly improve resource utilization efficiency.Originality/value-The proposed model demonstrates both scientific rigor and practical effectiveness.In realworld operations,it can provide operators with preliminary and proactive functional allocation schemes,help identify key constraints limiting hub capacity utilization and offer decision support for transport plan adjustments or infrastructure and facility upgrades.展开更多
This paper investigates an aggregated design and optimization method for permanent magnet hub(PMH)motors,guided by permeance harmonics,to meet low-speed,high-torque requirements.The key lies in establishing the correl...This paper investigates an aggregated design and optimization method for permanent magnet hub(PMH)motors,guided by permeance harmonics,to meet low-speed,high-torque requirements.The key lies in establishing the correlation between stator and rotor permeance harmonics and torque.Firstly,contribution equations describing the influence of stator and rotor permeance harmonics on torque are derived.It reveals that the contribution degree is affected by harmonic amplitude and phase.Then,the selection criteria for stator and rotor topology are formulated.The amplitude and phase characteristics of the permeance harmonic group are considered in criteria,which aim to achieve the aggregated design from a permeance harmonic perspective.Furthermore,based on the identified aggregated permeance harmonics,the airgap flux density harmonics directly linked to permeance harmonics are determined.Taking these harmonics as the goal,they are involved in the optimization process for high torque density.Sensitivity analysis and response surface analysis are adopted,respectively,to lock the design variables and their parameter ranges.Then,the motor topology with characteristics of high torque density is obtained through multi-objective optimization.Finally,a prototype experiment is conducted on the optimized PMH motor.展开更多
Background:Alzheimer's disease(AD)represents the most prevalent neurodegenerative disorder,with mitochondrial dysfunction being observed in both AD patients and mouse models.Nonetheless,further investigation is re...Background:Alzheimer's disease(AD)represents the most prevalent neurodegenerative disorder,with mitochondrial dysfunction being observed in both AD patients and mouse models.Nonetheless,further investigation is required to elucidate the pathogenic genes associated with AD and to develop early diagnostic methodologies centered on mitochondrial function.Methods:In this study,the dataset GSE132903 was retrieved from the GEO database,encompassing both non-demented(ND)control and AD samples.Through the combination of differential expression gene analysis,weighted gene co-expression network analysis,and intersection with mitochondrial database gene sets,four hub genes associated with AD were identified.These four hub genes were subsequently validated in APP/PS1 and 5xFAD mouse models using molecular biology techniques.Results:The hub genes identified through bioinformatics analysis include SYNJ2BP,VDAC1,NUBPL,and COX19.Within the GSE132903 dataset,the expression levels of SYNJ2BP,NUBPL,and COX19 were significantly elevated in the AD group compared to the non-demented(ND)group,whereas VDAC1 expression was reduced in the AD group relative to the ND group.Furthermore,in the hippocampus of APP/PS1 and 5xFAD mouse models,the expression patterns of SYNJ2BP and NUBPL were consistent with the bioinformatics analysis results.Conclusion:Hub genes identified here through bioinformatics and molecular biology may help early diagnosis of AD patients and may also help build new AD models to explore its pathogenesis.展开更多
This article provides an in-depth commentary on the study by Wang et al,which elucidates that the hypoxia-inducible factor-1α(HIF-1α)/β-catenin axis serves as a core hub regulating the function of peripheral blood ...This article provides an in-depth commentary on the study by Wang et al,which elucidates that the hypoxia-inducible factor-1α(HIF-1α)/β-catenin axis serves as a core hub regulating the function of peripheral blood mesenchymal stem cells(PBMSCs)under hypoxic conditions.The research confirms that in a hypoxic environment,HIF-1αacts as an upstream regulator by directly binding to and activating the transcription ofβ-catenin,a relationship that is unidirectional and irreversible.This axis enhances the therapeutic potential of PBMSCs through a dual mechanism:On one hand,it regulates anti-apoptotic proteins while inhibiting pro-apoptotic molecules,significantly improving cell survival and self-renewal capacity;on the other hand,it promotes the secretion of factors such as vascular endothelial growth factor,thereby enhancing angiogenic activity.In a rat myocardial infarction model,PBMSCs overexpressing HIF-1αshowed significantly improved retention in the infarcted area,reduced infarct size,and promoted neovascularization-effects that were abolished upon knockdown ofβ-catenin.This discovery provides a key target for optimizing stem cell therapy for myocardial infarction.By pre-activating this axis in vitro(e.g.,via lentiviral vectors or small-molecule regulators),it is possible to standardize and enhance the survival and reparative capacity of PBMSCs in ischemic tissues,holding important translational medical value.展开更多
The parking order of non-motor vehicles at a comprehensive transportation hub is a critical factor affecting transfer efficiency and travel experience.In this paper,the parking conditions of nonmotor vehicles at all e...The parking order of non-motor vehicles at a comprehensive transportation hub is a critical factor affecting transfer efficiency and travel experience.In this paper,the parking conditions of nonmotor vehicles at all entrances and exits of Pingguoyuan Comprehensive Transportation Hub were studied through field observation and photographic documentation,and the parking issues and root causes at three typical access points(E,H,and B)were thoroughly discussed.It is found that non-motor vehicle parking at the hub faces three universal constraints,such as unbalanced supply and demand,uneven provision of supporting facilities,and weak parking order management.Each of the three entrances shows distinct challenges.Entrance E suffers from insufficient parking space and inadequate signage;entrance H lacks overhead shelters despite adequate basic supporting facilities;entrance B faces overloaded parking capacity and deficient on-site management.In response to these issues,differentiated improvement schemes were put forward,including expanding parking zones,installing overhead shelters,tapping underutilized space to increase parking capacity,and establishing standardized regular management mechanisms.The research findings can serve as a reference for improving the parking management of non-motor vehicles at Pingguoyuan Hub and other analogous comprehensive transportation hubs.展开更多
Over the past months,a southern Chinese harbor serving as a pivotal gateway to regions around the world has come into the spotlight after the launching of special customs operations on Hainan Island.LOCATED on the nor...Over the past months,a southern Chinese harbor serving as a pivotal gateway to regions around the world has come into the spotlight after the launching of special customs operations on Hainan Island.LOCATED on the northwest tip of HainanIsland,the Yangpu Port is a scene ofbustling activity with towering gantrycranes busily loading containers on andoff large cargo vessels.Port orders here have surgedas a result of a slew of special customs policiesthat went into force last December.展开更多
AS the global innovation landscape undergoes rapid changes,Beijing is redefining China’s technological frontier with the steadiness and ambition of true innovation.The city’s society-wide R&D investment intensit...AS the global innovation landscape undergoes rapid changes,Beijing is redefining China’s technological frontier with the steadiness and ambition of true innovation.The city’s society-wide R&D investment intensity has remained above six percent for many years.Its investment in basic research has ranked first on the Nature Index Science Cities for nine consecutive years,and nearly 30 percent of China’s national key laboratories are based in Beijing.展开更多
As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Gua...As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Guanyinshan Showroom,the brand's second and largest comprehensive showroom,was officially inaugurated.This showroom is more than a product display window,it is an"Inspiration Hub"integrating exhibition,co-creation,and service.Its launch signifies YKK's progression in the Chinese market from“building an efficient product proposal system”to a new stage of“deep collaborative co-creation.”展开更多
Large scale reservoir hubs are key control projects in the flood control system and water resource allocation pattern of the basin. Their safe operation and scientific scheduling are directly related to the safety of ...Large scale reservoir hubs are key control projects in the flood control system and water resource allocation pattern of the basin. Their safe operation and scientific scheduling are directly related to the safety of millions of people's lives and property downstream, as well as regional economic and social development. The digital twin technology is driving a profound transformation in reservoir management from "experience driven" to "data-driven" and from "passive response" to "active prediction" by constructing a "digital avatar" that maps and interacts with physical reservoirs in real-time. This article systematically analyzes the core value of the construction of a digital twin platform for large-scale reservoir hubs, and summarizes the key technical systems from three aspects: integrated monitoring and perception of "sky ground water engineering", construction of data base and model platform, and development of intelligent business applications. Typical projects such as Datongxia, Miyun Reservoir, and Danjiangkou are used as cases to analyze the practical experience of implementation. On this basis, in response to the current bottlenecks such as insufficient perception coverage, difficulties in data fusion, need for improvement in model accuracy, and inconsistent standards and specifications, promotion strategies have been proposed from four dimensions: consolidating the perception base, tackling data fusion, deepening model research and development, and improving the standard system. The aim is to provide theoretical reference and practical path for the digital twin platform of large-scale reservoir hubs to move from "demonstration exploration" to "large-scale implementation".展开更多
To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to mi...To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to minimize total time expenditure is constructed.It incorporates parking search time,walking time,and departure time,focusing on short-term parking features.Then,the information dimensions that the parking lot can obtain are evaluated,and three assignment strategies based on three types of regression models-linear regression(LR),extreme gradient boosting(XGBoost),and multilayer perceptron(MLP)-are proposed.A parking process simulation model is built using the traffic simulation package SUMO to facilitate data collection,model training,and case studies.Finally,the performance of the three strategies is com-pared,revealing that the XGBoost-based strategy performs the best in case parking lots,which reduces time expendi-ture by 29.3%and 37.2%,respectively,compared with the MLP-based strategy and LR-based strategy.This method offers diverse options for practical parking manage-ment.展开更多
The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diff...The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diffraction,transmission electron microscopy,and finite element simulation revealed that continuous dynamic recrystallization(CDRX)and grain boundary bulging occurred simultaneously throughout the spinning process,leading to an increased proportion of DRXed grain areas.The newly formed DRXed grains largely retained the orientations of their deformed parent grains.The spinning process had two stages:initially,deformation was driven by basalslip as the roller contacted the alloy and descended to its lowest point.In the later stage,pyramidalslips became predominant as additional force was applied along the spinning direction(SD),forming a final texture with the c-axis tilting±15°towards the SD.This texture development led to discernible anisotropy in tensile properties along the SD and the tangential direction(TD).展开更多
Objective Sepsis-induced acute lung injury(ALI)poses a critical challenge in critical care,yet its immunoregulatory mechanisms remain poorly defined.This study aimed to delineate immune dysregulation networks and iden...Objective Sepsis-induced acute lung injury(ALI)poses a critical challenge in critical care,yet its immunoregulatory mechanisms remain poorly defined.This study aimed to delineate immune dysregulation networks and identify therapeutic targets through multiomics data integration.Methods Transcriptomic datasets(GSE40180 and GSE165226)were analyzed through a multiphase bioinformatics workflow,including gene set enrichment analysis(GSEA),immune cell deconvolution(CIBERSORT),differential gene expression profiling(|log2FC|>1.5,P.adj0.85,P<0.001).Conclusion Innate adaptive immune crosstalk,particularly dysregulated immune cell infiltration,drives sepsis-induced ALI pathogenesis.The 7 hub genes mechanistically connect immune dyshomeostasis to tissue injury,suggesting novel targets for precision immunomodulation and biomarker development in critical care.展开更多
This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar ...This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.展开更多
To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characte...To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characteristics of each floor vibration were obtained through the time domain and frequency domain analyses.Based on the vibration characteristic under multiple-source excitations,the proposed attenuation model was derived.In addition,a vibration comfort evaluation on the Wuhan Railway Station was conducted.The results show that the effect of the number of vibration sources on horizontal acceleration is more significant than that regarding vertical acceleration.When the structure is under the effects two vibration sources with different frequencies,a high-frequency vibration can amplify a low-frequency vibration.The derived attenuation model can precisely predict the vibration attenuation and reduce the subsequent vibration test workload.Based on the annoyance rate model result,the annoyance rate of Wuhan Railway Station is high,which is harmful to the staff of the station.展开更多
Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this sys...Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.展开更多
基金China Academy of Railway Sciences Research Fund(award number:2024YJ50).
摘要Purpose-With the continuous expansion of railway hubs,increasing functional complexity and growing capacity constraints,the coordinated and efficient utilization of transportation resources-such as stations,lines and maintenance facilities-has become a critical issue for improving hub operational efficiency.This study focuses on the division of functions within railway hubs that incorporate shared stations operating under mixed high-speed and conventional train services.Design/methodology/approach-An optimization model for hub functional allocation is developed to achieve efficient resource utilization in hubs containing mixed-operation stations.A node-arc network representation combined with an improved multi-commodity flow model is employed,taking train dwell and operation time within the hub as the optimization objective.A case study is conducted to derive optimized solutions,followed by both qualitative and quantitative analyses.Findings-The results indicate that optimizing train operation routes and station assignments within the hub can effectively reduce the total occupation time of train flows and significantly improve resource utilization efficiency.Originality/value-The proposed model demonstrates both scientific rigor and practical effectiveness.In realworld operations,it can provide operators with preliminary and proactive functional allocation schemes,help identify key constraints limiting hub capacity utilization and offer decision support for transport plan adjustments or infrastructure and facility upgrades.
基金supported by the National Natural Science Foundation of China under Grant 52577056。
摘要This paper investigates an aggregated design and optimization method for permanent magnet hub(PMH)motors,guided by permeance harmonics,to meet low-speed,high-torque requirements.The key lies in establishing the correlation between stator and rotor permeance harmonics and torque.Firstly,contribution equations describing the influence of stator and rotor permeance harmonics on torque are derived.It reveals that the contribution degree is affected by harmonic amplitude and phase.Then,the selection criteria for stator and rotor topology are formulated.The amplitude and phase characteristics of the permeance harmonic group are considered in criteria,which aim to achieve the aggregated design from a permeance harmonic perspective.Furthermore,based on the identified aggregated permeance harmonics,the airgap flux density harmonics directly linked to permeance harmonics are determined.Taking these harmonics as the goal,they are involved in the optimization process for high torque density.Sensitivity analysis and response surface analysis are adopted,respectively,to lock the design variables and their parameter ranges.Then,the motor topology with characteristics of high torque density is obtained through multi-objective optimization.Finally,a prototype experiment is conducted on the optimized PMH motor.
基金Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,Grant/Award Number:2023-PT180-01 and 2023-PT330-01Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-034National Natural Science Foundation of China,Grant/Award Number:82161138027。
摘要Background:Alzheimer's disease(AD)represents the most prevalent neurodegenerative disorder,with mitochondrial dysfunction being observed in both AD patients and mouse models.Nonetheless,further investigation is required to elucidate the pathogenic genes associated with AD and to develop early diagnostic methodologies centered on mitochondrial function.Methods:In this study,the dataset GSE132903 was retrieved from the GEO database,encompassing both non-demented(ND)control and AD samples.Through the combination of differential expression gene analysis,weighted gene co-expression network analysis,and intersection with mitochondrial database gene sets,four hub genes associated with AD were identified.These four hub genes were subsequently validated in APP/PS1 and 5xFAD mouse models using molecular biology techniques.Results:The hub genes identified through bioinformatics analysis include SYNJ2BP,VDAC1,NUBPL,and COX19.Within the GSE132903 dataset,the expression levels of SYNJ2BP,NUBPL,and COX19 were significantly elevated in the AD group compared to the non-demented(ND)group,whereas VDAC1 expression was reduced in the AD group relative to the ND group.Furthermore,in the hippocampus of APP/PS1 and 5xFAD mouse models,the expression patterns of SYNJ2BP and NUBPL were consistent with the bioinformatics analysis results.Conclusion:Hub genes identified here through bioinformatics and molecular biology may help early diagnosis of AD patients and may also help build new AD models to explore its pathogenesis.
基金Supported by the Natural Science Research Project of Basic Research Program in Shanxi Province,No.202203021221268the National Natural Science Foundation of China,No.82305030the Special Fund from Medicinal Basic Research Innovation Center of Chronic Kidney Disease,Ministry of Education,Shanxi Medical University,No.CKD/SXMU-2024-04.
摘要This article provides an in-depth commentary on the study by Wang et al,which elucidates that the hypoxia-inducible factor-1α(HIF-1α)/β-catenin axis serves as a core hub regulating the function of peripheral blood mesenchymal stem cells(PBMSCs)under hypoxic conditions.The research confirms that in a hypoxic environment,HIF-1αacts as an upstream regulator by directly binding to and activating the transcription ofβ-catenin,a relationship that is unidirectional and irreversible.This axis enhances the therapeutic potential of PBMSCs through a dual mechanism:On one hand,it regulates anti-apoptotic proteins while inhibiting pro-apoptotic molecules,significantly improving cell survival and self-renewal capacity;on the other hand,it promotes the secretion of factors such as vascular endothelial growth factor,thereby enhancing angiogenic activity.In a rat myocardial infarction model,PBMSCs overexpressing HIF-1αshowed significantly improved retention in the infarcted area,reduced infarct size,and promoted neovascularization-effects that were abolished upon knockdown ofβ-catenin.This discovery provides a key target for optimizing stem cell therapy for myocardial infarction.By pre-activating this axis in vitro(e.g.,via lentiviral vectors or small-molecule regulators),it is possible to standardize and enhance the survival and reparative capacity of PBMSCs in ischemic tissues,holding important translational medical value.
基金Sponsored by the Special Program for Postgraduate Education and Teaching Reform of North China University of Technology in 2026.
摘要The parking order of non-motor vehicles at a comprehensive transportation hub is a critical factor affecting transfer efficiency and travel experience.In this paper,the parking conditions of nonmotor vehicles at all entrances and exits of Pingguoyuan Comprehensive Transportation Hub were studied through field observation and photographic documentation,and the parking issues and root causes at three typical access points(E,H,and B)were thoroughly discussed.It is found that non-motor vehicle parking at the hub faces three universal constraints,such as unbalanced supply and demand,uneven provision of supporting facilities,and weak parking order management.Each of the three entrances shows distinct challenges.Entrance E suffers from insufficient parking space and inadequate signage;entrance H lacks overhead shelters despite adequate basic supporting facilities;entrance B faces overloaded parking capacity and deficient on-site management.In response to these issues,differentiated improvement schemes were put forward,including expanding parking zones,installing overhead shelters,tapping underutilized space to increase parking capacity,and establishing standardized regular management mechanisms.The research findings can serve as a reference for improving the parking management of non-motor vehicles at Pingguoyuan Hub and other analogous comprehensive transportation hubs.
摘要Over the past months,a southern Chinese harbor serving as a pivotal gateway to regions around the world has come into the spotlight after the launching of special customs operations on Hainan Island.LOCATED on the northwest tip of HainanIsland,the Yangpu Port is a scene ofbustling activity with towering gantrycranes busily loading containers on andoff large cargo vessels.Port orders here have surgedas a result of a slew of special customs policiesthat went into force last December.
摘要AS the global innovation landscape undergoes rapid changes,Beijing is redefining China’s technological frontier with the steadiness and ambition of true innovation.The city’s society-wide R&D investment intensity has remained above six percent for many years.Its investment in basic research has ranked first on the Nature Index Science Cities for nine consecutive years,and nearly 30 percent of China’s national key laboratories are based in Beijing.
摘要As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Guanyinshan Showroom,the brand's second and largest comprehensive showroom,was officially inaugurated.This showroom is more than a product display window,it is an"Inspiration Hub"integrating exhibition,co-creation,and service.Its launch signifies YKK's progression in the Chinese market from“building an efficient product proposal system”to a new stage of“deep collaborative co-creation.”
摘要Large scale reservoir hubs are key control projects in the flood control system and water resource allocation pattern of the basin. Their safe operation and scientific scheduling are directly related to the safety of millions of people's lives and property downstream, as well as regional economic and social development. The digital twin technology is driving a profound transformation in reservoir management from "experience driven" to "data-driven" and from "passive response" to "active prediction" by constructing a "digital avatar" that maps and interacts with physical reservoirs in real-time. This article systematically analyzes the core value of the construction of a digital twin platform for large-scale reservoir hubs, and summarizes the key technical systems from three aspects: integrated monitoring and perception of "sky ground water engineering", construction of data base and model platform, and development of intelligent business applications. Typical projects such as Datongxia, Miyun Reservoir, and Danjiangkou are used as cases to analyze the practical experience of implementation. On this basis, in response to the current bottlenecks such as insufficient perception coverage, difficulties in data fusion, need for improvement in model accuracy, and inconsistent standards and specifications, promotion strategies have been proposed from four dimensions: consolidating the perception base, tackling data fusion, deepening model research and development, and improving the standard system. The aim is to provide theoretical reference and practical path for the digital twin platform of large-scale reservoir hubs to move from "demonstration exploration" to "large-scale implementation".
基金The National Natural Science Foundation of China(No.52302388)the Natural Science Foundation of Jiangsu Province(No.BK20230853).
摘要To adapt to the unique demand-supply features of accessory parking lots at passenger transport hubs,a mixed parking demand assignment method based on regression modeling is proposed.First,an optimal model aiming to minimize total time expenditure is constructed.It incorporates parking search time,walking time,and departure time,focusing on short-term parking features.Then,the information dimensions that the parking lot can obtain are evaluated,and three assignment strategies based on three types of regression models-linear regression(LR),extreme gradient boosting(XGBoost),and multilayer perceptron(MLP)-are proposed.A parking process simulation model is built using the traffic simulation package SUMO to facilitate data collection,model training,and case studies.Finally,the performance of the three strategies is com-pared,revealing that the XGBoost-based strategy performs the best in case parking lots,which reduces time expendi-ture by 29.3%and 37.2%,respectively,compared with the MLP-based strategy and LR-based strategy.This method offers diverse options for practical parking manage-ment.
基金funded by the National Natural Science Foundation of China(No.52204407)the Natural Science Foundation of Jiangsu Province,China(No.BK20220595)the China Postdoctoral Science Foundation(No.2022M723689)。
摘要The dynamic recrystallization(DRX)behavior and texture formation mechanism in an AZ31 magnesium alloy wheel hub during the spinning process were investigated.Analysis using optical microscopy,electron backscatter diffraction,transmission electron microscopy,and finite element simulation revealed that continuous dynamic recrystallization(CDRX)and grain boundary bulging occurred simultaneously throughout the spinning process,leading to an increased proportion of DRXed grain areas.The newly formed DRXed grains largely retained the orientations of their deformed parent grains.The spinning process had two stages:initially,deformation was driven by basalslip as the roller contacted the alloy and descended to its lowest point.In the later stage,pyramidalslips became predominant as additional force was applied along the spinning direction(SD),forming a final texture with the c-axis tilting±15°towards the SD.This texture development led to discernible anisotropy in tensile properties along the SD and the tangential direction(TD).
基金supported by the National Natural Science Foundation of China(No.82300114)the Natural Science Foundation of Hubei Province General Program(No.2023AFB684)the Natural Science Foundation of Hubei Province Youth Program(No.2022CFB671).
摘要Objective Sepsis-induced acute lung injury(ALI)poses a critical challenge in critical care,yet its immunoregulatory mechanisms remain poorly defined.This study aimed to delineate immune dysregulation networks and identify therapeutic targets through multiomics data integration.Methods Transcriptomic datasets(GSE40180 and GSE165226)were analyzed through a multiphase bioinformatics workflow,including gene set enrichment analysis(GSEA),immune cell deconvolution(CIBERSORT),differential gene expression profiling(|log2FC|>1.5,P.adj0.85,P<0.001).Conclusion Innate adaptive immune crosstalk,particularly dysregulated immune cell infiltration,drives sepsis-induced ALI pathogenesis.The 7 hub genes mechanistically connect immune dyshomeostasis to tissue injury,suggesting novel targets for precision immunomodulation and biomarker development in critical care.
基金supported in part by the National Nat-ural Science Foundation of China(No.51977012,No.52307080).
摘要This study proposes a method for analyzing the security distance of an Active Distribution Network(ADN)by incorporating the demand response of an Energy Hub(EH).Taking into account the impact of stochastic wind-solar power and flexible loads on the EH,an interactive power model was developed to represent the EH’s operation under these influences.Additionally,an ADN security distance model,integrating an EH with flexible loads,was constructed to evaluate the effect of flexible load variations on the ADN’s security distance.By considering scenarios such as air conditioning(AC)load reduction and base station(BS)load transfer,the security distances of phases A,B,and C increased by 17.1%,17.2%,and 17.7%,respectively.Furthermore,a multi-objective optimal power flow model was formulated and solved using the Forward-Backward Power Flow Algorithm,the NSGA-II multi-objective optimization algo-rithm,and the maximum satisfaction method.The simulation results of the IEEE33 node system example demonstrate that after opti-mization,the total energy cost for one day is reduced by 0.026%,and the total security distance limit of the ADN’s three phases is improved by 0.1 MVA.This method effectively enhances the security distance,facilitates BS load transfer and AC load reduction,and contributes to the energy-saving,economical,and safe operation of the power system.
基金Science Fund for Distinguished Young Scholars of Hubei Province under Grant No.2023AFA103National Natural Science Foundation of China under Grant No.52078395+1 种基金Open Projects Foundation of State Key Laboratory for Health and Safety of Bridge Structures under Grant No.BHSKL19-07-GFYoung Top-Notch Talent Cultivation Program of Hubei Province。
摘要To investigate the vibration response of the comprehensive transportation hub structure under multiple-source excitations,an on-site vibration measurement was carried out at Wuhan Railway Station in China.The characteristics of each floor vibration were obtained through the time domain and frequency domain analyses.Based on the vibration characteristic under multiple-source excitations,the proposed attenuation model was derived.In addition,a vibration comfort evaluation on the Wuhan Railway Station was conducted.The results show that the effect of the number of vibration sources on horizontal acceleration is more significant than that regarding vertical acceleration.When the structure is under the effects two vibration sources with different frequencies,a high-frequency vibration can amplify a low-frequency vibration.The derived attenuation model can precisely predict the vibration attenuation and reduce the subsequent vibration test workload.Based on the annoyance rate model result,the annoyance rate of Wuhan Railway Station is high,which is harmful to the staff of the station.
基金supported by the Natural Science Foundation of Hunan Province,China(Grant Nos.2023JJ50178 and 2023JJ50194)the Excellent Youth Project of Hunan Provincial Department of Education(Grant No.23B0542).
摘要Rack-level loop thermosyphons have been widely adopted as a solution to data centers’growing energy demands.While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system,its economic feasibility,water usage effectiveness(WUE),and carbon usage effectiveness(CUE)remain underexplored.This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes.The air wet bulb temperature Ta,w was identified as the most significant factor influencing the variability in the combination of PUE,CUE,and WUE values.The results indicate that the rack-level loop thermosyphon system achieves the highest score in Lanzhou(94.485)and the lowest in Beijing(89.261)based on the comprehensive evaluation index.The overall ranking of cities according to the comprehensive evaluation score is as follows:Gansu hub(Lanzhou)>Inner Mongolia hub(Hohhot)>Ningxia hub(Yinchuan)>Yangtze River Delta hub(Shanghai)>Chengdu Chongqing hub(Chongqing)>Guangdong-Hong Kong-Macao Greater Bay Area hub(Guangzhou)>Guizhou hub(Guiyang)>Beijing-Tianjin-Hebei hub(Beijing).Furthermore,Hohhot,Lanzhou,and Yinchuan consistently rank among the top three cities for comprehensive scores across all load rates,while Guiyang(at a 25%load rate),Guangzhou(at a 50%load rate),and Beijing(at 75%and 100%load rates)exhibited the lowest comprehensive scores.