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Human leukemia antigen-A0201-restricted epitopes of humanendogenous retrovirus W family envelope(HERV-W env)inducestrong cytotoxic T lymphocyte responses 认领 引用 被引量：5
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作者 Xiaoning Tu Shan Li +3 位作者 Lijuan Zhao Ran Xiao Xiuling Wang Fan Zhu 《Virologica Sinica》 SCIE CAS CSCD 2017年第4期280-289,共10页
Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports... Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports investigating whether human leukemia antigen(HLA)-A~*0201^+restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. In the present study, HERV-W env-derived epitopes presented by HLA-A~*0201 are described with the potential for use in adoptive immunotherapy. Five peptides displaying HLAA~*0201-binding motifs were predicted using SYFEPITHI and BIMAS, and synthesized. A CCK-8 assay showed peptides W, Q and T promoted lymphocyte proliferation. Stimulation of peripheral blood mononuclear cells from HLA-A~*0201^+ donors with each of these peptides induced peptidespecific CD8^+ T cells. High numbers of IFN-γ-secreting T cells were also detectable after several weekly stimulations with W, Q and T. Besides lysis of HERV-W env-loaded target cells, specific apoptosis was also observed. These data demonstrate that human T cells can be sensitized toward HERV-W env peptides(W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. In conclusion, peptides W Q and T, which are HERV-W env antigenic epitopes, have both antigenicity and immunogenicity, and can cause strong T cell immune responses. Our data strengthen the view that HERV-W env should be considered as an autoantigen that can induce autoimmunity in neuropsychiatric diseases, such as multiple sclerosis and schizophrenia. These data might provide an experimental foundation for a HERV-W env peptide vaccine and new insight into the treatment of neuropsychiatric diseases. 展开更多
关键词 Human endogenous retrovirus W (HERV-W) env peptide HLA CTL
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The Religious and Humane Significance of the Death of Two Heroes in Scarlet Letter 认领 引用
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作者 邴照宇 《海外英语》 2014年第17期180-180,191,共1页
Most of Nathaniel Hawthorne's masterpieces are created with the theme of morality,and are used to analysis and reveal"good and evil human nature"through the methods of profound symbolism and delicate psy... Most of Nathaniel Hawthorne's masterpieces are created with the theme of morality,and are used to analysis and reveal"good and evil human nature"through the methods of profound symbolism and delicate psychological description. To reemerge the spirit of The Scarlet Letter,Which is considered as Hawthorne's religious view and humanistic feeling,the death of two heroes in this novel should be analyzed in the aspects of religion and human nature,and even in the aspects of the vocabulary,theme and mental world of main characters. 展开更多
关键词 religion death humanistic feeling human nature
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Charting bioethical frontiers:China’s human organoid guidelines in a global context 认领 引用 被引量：2
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作者 Liang-Bin Zhou Yi-Ting Lei Xin-Xin Han 《Military Medical Research》 SCIE CAS CSCD 2026年第2期340-344,共5页
The rapid progress of human organoid toolkits presents unprecedented opportunities in disease modeling,drug discovery,and personalized therapy,alongside profound bioethical challenges and concerns.On April 29th,2025,C... The rapid progress of human organoid toolkits presents unprecedented opportunities in disease modeling,drug discovery,and personalized therapy,alongside profound bioethical challenges and concerns.On April 29th,2025,China’s National Science and Technology Ethics Committee(Life Science Ethics Subcommittee)issued the Human Organoid Research Ethical Guidelines[1],establishing the world’s first comprehensive governance framework,especially focusing on brain organoids,embryo models,and chimeric research.This Guidelines represent a pioneering governance model in emerging biotechnology.This commentary offers an in-depth analysis to examine the policy’s innovative three-tiered structure,contrast it with current global regulatory standards,evaluate its domestic impacts as well as potential implications for international biotechnology governance,and provide recommendations for future directions. 展开更多
关键词 Human organoids Regulatory policy Ethical guidelines Brain organoids Embryo models Organoid chimeras
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Methods of preparation,structural characteristics of resistant starch and its relation to human health:a review 认领 引用 被引量：1
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作者 Weiyi Zhang Yang Yang +6 位作者 Chunmin Ma Bing Wang Xiaofei Liu Yan Wang Xin Bian Guang Zhang Na Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1503-1519,共17页
Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromo... Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromoting ingredients that can regulate blood glucose and lipid levels,prevent cancer,and enhance the quality of life.Consequently,new technologies for the preparation of RS are continually being developed to support its industrial production.This review describes the structural and nutritional properties of RS and examines recent advancements in RS preparation methods.Emphasis is placed on how RS structure influences its properties and the physiological mechanisms in vivo.This review aims to stimulate further research into the preparation methods,functional characteristics,and utilization of RS,thereby supporting ongoing developments in the food industry. 展开更多
关键词 Resistant starch Preparation methods Characterization Function Human health
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Development of nontarget method based on GC-QTOF-HRMS for analyzing organic pollutants in human serum 认领 引用 被引量：1
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作者 Congcong Yue Chang He +5 位作者 Hailing Li Zhiquan Yuan Guiying Li Shengtao Ma Xin Zhang Taicheng An 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期379-386,共8页
Traditional targeted analyses often overlook unknown or emerging contaminants,highlighting the significance of nontarget and suspect screening approaches.A novel and high-sensitivity methodology for nontarget analysis... Traditional targeted analyses often overlook unknown or emerging contaminants,highlighting the significance of nontarget and suspect screening approaches.A novel and high-sensitivity methodology for nontarget analysis of organic pollutants in human serum was newly-developed based on gas chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry.The extraction protocol employing an acetonitrile-ethyl acetate(9:1,V:V)mixture significantly improved the extraction efficiency while minimizing matrix effect.A hybridized analytical strategy integrating nontarget and suspect screening was developed to achieve comprehensive identification and classification of pollutants,employing the National Institute of Standards and Technology(NIST)20 library and Agilent Technologies Personal Compound Database and Library(PCDL).This approach successfully characterized 273 organic contaminants spanning 12 categories,including polycyclic aromatic hydrocarbons(PAHs)and their derivatives,esters,and phenolic compounds in human serum,with a significant increase in detection specificity compared to conventional workflows.The methodology used serum samples of the workers from coking industry,revealing widespread contamination dominated by PAHs and PAH derivatives.Among the target analytes,three were identified solely by NIST and six solely by PCDL,indicating the complementary benefits of combining these different databases.Notably,this work reported the first confirmed detection of 2-naphthalenamine in human serum.This optimized approach demonstrates enhanced sensitivity and reliability in serum analysis,advancing biomonitoring capabilities and providing a deep understanding of human exposure to environmental pollutants. 展开更多
关键词 Nontarget analysis Biomonitoring method Human serum sample Organic pollutants GC-QTOF-HRMS
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Patterns,synergies,and interactions between human activities and living environment on the Qinghai-Xizang Plateau 认领 引用 被引量：1
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作者 GUO Changqing ZHANG Haiyan +2 位作者 DOU Yinyin KUANG Wenhui BAO Wenxuan 《Journal of Geographical Sciences》 SCIE CSCD 2026年第2期341-362,共22页
Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic inte... Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic interactions between human activities and the living environment on the Qinghai-Xizang Plateau(QXP)remain limited,with a paucity of quantitative relationship analyses.This study established an assessment framework to evaluate human influences on the living environment in QXP,using data on typical human activities,ecological conditions,and human settlements.Within this framework,the spatial analysis methods and the coupling coordination model were used to examine the spatio-temporal characteristics and relationship of human activities and living environment on the QXP from 2000 to 2020.The geographical detector model was then applied to identify the key factors influencing the plateau’s human living environment.Subsequently,the four-quadrant analysis model was adopted to assess human influences on the living environment.The results indicate that the human activity intensity(HAI)on the QXP remained relatively low yet increased by 15.41%from 2000 to 2020.Spatially,the human living environment quality(LEQ)improved from northwest to southeast,with 61.14%of the areas remaining stable and 18.47%experiencing slight improvement.The analysis of coupling coordination revealed a continuous improvement between the HAI and LEQ,with the areas of high and relatively high coordinated types increasing by more than 9%.Precipitation and urban-rural construction were identified as the primary factors influencing changes in the LEQ.The interaction between the HAI and LEQ was strengthening,with 40.44%classified as coordinated development type and 38.35%as development-environment conflict type.These findings provide valuable insights for enhancing the resilience of human settlements and promoting green development across the plateau. 展开更多
关键词 human activities living environment spatio-temporal characteristics coupling coordination influencing factor Qinghai-Xizang Plateau
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Deep Learning-Enhanced Human Sensing with Channel State Information: A Survey 认领 引用 被引量：1
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作者 Binglei Yue Aili Jiang +3 位作者 Chun Yang Junwei Lei Heng Liu Yin Zhang 《Computers, Materials & Continua》 SCIE EI 2026年第1期1-28,共28页
With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State I... With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing. 展开更多
关键词 Channel State Information(CSI) human sensing human activity recognition deep learning
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ALDH2 in autophagy and cell death:molecular mechanisms and implications for diseases 认领 引用 被引量：1
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作者 Yu Duan Ze-Chen Shan +1 位作者 Jiao-Jiao Pang Yu-Guo Chen 《Military Medical Research》 SCIE CAS CSCD 2026年第2期239-266,共28页
Aldehyde dehydrogenase 2(ALDH2),a mitochondrial enzyme,is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes.The ALDH2rs671mutation affects 560 m... Aldehyde dehydrogenase 2(ALDH2),a mitochondrial enzyme,is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes.The ALDH2rs671mutation affects 560 million East Asians and is closely related to an increased risk of various human diseases.In addition to its well-known function in detoxifying alcohol-derived acetaldehyde and endogenous aldehydes,ALDH2 is implicated in human health through its regulation of autophagic machinery and multiple cell death pathways(e.g.,apoptosis,necroptosis,pyroptosis,ferroptosis,and NETosis).This review summarizes the current knowledge of ALDH2 and the regulatory mechanism through which ALDH2 regulates autophagy and cell death.In addition,we outline the potential role of ALDH2 in the regulation of autophagy and cell death during the occurrence and progression of human diseases,aiming to provide a novel theoretical framework for human disease treatment. 展开更多
关键词 Aldehyde dehydrogenase 2(ALDH2) Autophagy Cell death Human diseases
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Disservices in terrestrial and freshwater ecosystems.The negative side of the ecosystems 认领 引用 被引量：1
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作者 Paulo Pereira Emoke Dalma Kovacs +2 位作者 Melinda Haydee Kovacs Miguel Inácio Wenwu Zhao 《Geography and Sustainability》 CSCD 2026年第2期1-6,共6页
1.Background Ecosystems supply a wide range of goods and services.This has been an important research topic for decades,and numerous works have argued that ecosystems are key to human wellbeing(Pinto et al.,2022).The ... 1.Background Ecosystems supply a wide range of goods and services.This has been an important research topic for decades,and numerous works have argued that ecosystems are key to human wellbeing(Pinto et al.,2022).The ecosystem services(ES)concept emerged from the idea that humans depend on the environment and is defined as the bene fits people obtain from ecosystems(MEA,2005).Although there are different classifications,ES are normally divided into Regulating,Pro visioning,and Cultural. 展开更多
关键词 human wellbeing goods services terrestrial ecosystems bene fits people obtain ecosystem services concept freshwater ecosystems ecosystem services negative impacts
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Human spinal cord organoids:A powerful tool to redefine gray matter and lower motor neuron pathophysiology in spinal cord injury 认领 引用 被引量：1
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作者 Maria Jose Quezada Colin K.Franz 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2001-2002,共2页
Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and geneti... Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI). 展开更多
关键词 human spinal cord organoids study neurotrauma spinal cord injury human spinal cord organoids hscos offer somatic cells egblood spinal cord traditional research modelsthese neurotrauma
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Human exposure to neonicotinoid insecticides:Safe or not? 认领 引用
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作者 Yishuang Duan Zhen Sun +4 位作者 Xiaoran Zhang Pu Wang Yong Liang Qunfang Zhou Guibin Jiang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期348-375,共28页
Neonicotinoid insecticides(NEOs)are a group of widely used insecticides in agriculture,livestock,and pest control for pets.However,increasing reports on their adverse effects on non-target organisms have aroused growi... Neonicotinoid insecticides(NEOs)are a group of widely used insecticides in agriculture,livestock,and pest control for pets.However,increasing reports on their adverse effects on non-target organisms have aroused growing public concerns.Therefore,it is necessary to evaluate NEO exposure and the related human health.This review summarized the human biomonitoring studies on NEOs,and the epidemiological,in vitro,and in vivo toxicological investigations on the health effects of NEOs.Human biomonitoring studies revealed significant changes in NEO detection frequencies,concentrations,and profiles across different human populations,suggesting potential variances in exposure patterns or metabolic processes.Certain metabolites may be more sensitive biomarkers than their parent molecules,as evidenced by higher levels of some NEO metabolites than those of their parent compounds.Although human epidemiological data has revealed associations between NEO exposure and diverse detrimental health outcomes including reproductive and developmental abnormalities,oxidative damage,etc.,the cross-sectional design of most studies cannot elucidate causality,necessitating further prospective research.In vitro and in vivo studies have shown various toxic effects of NEOs,including neurotoxicity,hepatotoxicity,reproductive toxicity,genotoxicity,etc.Further research on the molecular mechanisms beyond oxidative stress is worthwhile.Given metabolic activation,additional metabolites of both conventional and new generation NEOs as well as NEO-like compounds need to be determined,and their toxicities should be evaluated.This review can be contributed to the comprehensive understanding of the threat from extensive exposure to NEOs and proposed future research directions can aid to improve studies on health effects of NEOs. 展开更多
关键词 Neonicotinoid insecticides Human exposure Toxicity Human health
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Anogenital human papillomavirus infection patterns by anatomical site and sexual orientation in Chinese men:a national multi-center study 认领 引用
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作者 Shangying Hu Huan Yang +8 位作者 Jinyu Zhang Hongyang Yu Yutong Li Douhong Li Qiaoyun Du Yu Cui Xuelian Zhao Yongjiang Liu Fanghui Zhao 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第7期1044-1050,共7页
Human papillomavirus(HPV)is the most prevalent sexually transmitted infection worldwide1.More than 200 HPV genotypes have been identified and are classified as high-risk HPV(HR-HPV)or low-risk HPV(LR-HPV)according to ... Human papillomavirus(HPV)is the most prevalent sexually transmitted infection worldwide1.More than 200 HPV genotypes have been identified and are classified as high-risk HPV(HR-HPV)or low-risk HPV(LR-HPV)according to their oncogenic potential.Persistent infection with HR-HPV is associated with cancers of the cervix,vagina,vulva,anus,penis,and oropharynx.In contrast,LR-HPV infections cause benign lesions,such as genital warts and recurrent respiratory papillomatosis. 展开更多
关键词 genital warts anatomical site sexual orientation sexually transmitted infection human papillomavirus infection benign lesionssuch human papillomavirus hpv recurrent respiratory papillomatosis
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Directional effects of blast waves on human thorax:Dynamic response and injury mechanisms 认领 引用
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作者 Meng Zhou Minzu Liang +4 位作者 Yuliang Lin Jiaqiang Wu Zizhen Qi Yuwu Zhang Rong Chen 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第7期173-185,共13页
Blast injury is a leading cause of military casualties,and the thorax,which houses the lungs and heart,is particularly vulnerable to blast waves.While previous studies have primarily examined anterior ex-posures,the m... Blast injury is a leading cause of military casualties,and the thorax,which houses the lungs and heart,is particularly vulnerable to blast waves.While previous studies have primarily examined anterior ex-posures,the mechanisms of thoracic response and organ injury under multi-directional blasts remain poorly understood.In this study,a validated human finite element model was employed to investigate the effects of blast wave incident direction on thoracic injury.Results indicate that interaction between blast and the thorax consistently involves reflection,diffraction,and convergence,with pressures on the loaded side dominating the overall response.Strong direction-dependent effects were observed in pressure transmission and energy distribution:under anterior loading,the heart experienced pressure amplitudes 4.2 times higher than the lungs due to density contrasts;under posterior loading,organ energy absorption decreased to 5.39%owing to chest wall constraints;and under lateral loading,impedance mismatch of the heart attenuated contralateral lung pressures by more than 90%.Lung in-juries were concentrated in the inferior lobes due to weak constraints of the lower thoracic cage,while asymmetry between left and right lung damage was attributed to organ arrangement and cage defor-mation.These findings elucidate the directional dependence of thoracic blast injury mechanisms,of-fering new insights for injury assessment and the design of protective equipment. 展开更多
关键词 Blast injury Dynamic response Human thorax Directional dependence
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Advancement in bioremediation of heavy metals in sustainable way:A critical evaluation on current findings and future prospects 认领 引用
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作者 Sudhir K.Upadhyay Prabhat K.Chauhan +4 位作者 Vishnu D.Rajput Wenjing Dong Saglara S.Mandzhieva Yufei Zhao Tatiana Minkina 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期771-791,共21页
Hyperaccumulation of toxic heavy metals(THMs)by plants are extensively examined at the global level and considered a bioremediation strategy.The ability of hyperaccumulator plants(HPs)heavily depends on phytoextractio... Hyperaccumulation of toxic heavy metals(THMs)by plants are extensively examined at the global level and considered a bioremediation strategy.The ability of hyperaccumulator plants(HPs)heavily depends on phytoextraction,rhizofiltration,phytodegradation and rhizoremediation.The efficacy of HPs is significantly enhanced by their association with rhizospheric microbes.HPs utilizes the unique characteristics of root-associated microbes including secondary metabolites,siderophores,exopolysaccharides,phytochelatins and other substances.Despite this potential,field scale bioremediation strategies are still not effective in removing THMs from contaminated sites.The plant’s root exudates and microbe-based secondary metabolites have the capacity to remove THMs through specific gene expression.The advent of Clustered-Regularly-Interspaced-Short-Palindromic-Repeats(CRISPR)technology enables the targeted editing of genes in both plants and root-associated microbes.This allows researchers to investigate and optimize hyperaccumulator mechanisms,manipulate the production of key biochemical compound and induce HP mechanisms.The genetic advances in manipulating microbes,regulation of root exudates,factors and soil additive agents integrates in maintaining rhizospheric engineering to increase THM removal.This synergistic approach helps to restore soil health,food and nutritional quality to effectively reclaim THM sites.The present review comprehensively addressed the outcomes of extensive research on bioremediation and highlights the advancement in THM removal through advance genetic editing and nanobiotechnology.This article introduces the“Bioremediation 1.0-3.0″paradigm,which combines traditional phytoremediation with new methods including omics,CRISPR and nanobiotechnology.Key opportunities include deploying gene-edited plants,microbe-nanomaterial complexes and integrated rhizospheric engineering for sustainable clean-up,soil restoration and food security.These initiatives will provide adaptable,sustainable and successful solutions for reducing hazardous heavy metals,improving soil health,safeguarding food systems and protecting ecosystems. 展开更多
关键词 Phytoremediation Soil management Pollutants Toxicity Plants Human health
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Human‑robot interaction design with augmented reality in construction:A systematic review of frameworks,applications,and future directions 认领 引用
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作者 Tan TAN Xin LIU +2 位作者 Alexander N.WALZER Ming Shan NG Daniel M.HALL 《ENGINEERING Management》 CSCD 2026年第1期85-104,共20页
Research in human‑robot Interaction(HRI)has increasingly demonstrated how Augmented Reality(AR)enables better interactions between humans and robots.However,the design of HRI remains less understood.Through a systemat... Research in human‑robot Interaction(HRI)has increasingly demonstrated how Augmented Reality(AR)enables better interactions between humans and robots.However,the design of HRI remains less understood.Through a systematic literature review of 53 related papers,this research provides an overview of the emerging applications and trends for AR and identifies three types of AR interfaces as follows:1)remote modular interface,2)proximal modular interface,and 3)proximal integral interface.The review indicates potential future directions of construction‑oriented and human‑centric interaction design studies,leading to four pairs of subsystems,which are frequently modularised or integrated,and three conceptual frameworks for HRI interfaces are proposed.Moreover,this research contributes to the theoretical exploration of interaction design.Future applications can adapt to various tasks by using the proposed three conceptual frameworks for interfaces,as well as combining the four proposed subsystem pairs to suit specific task requirements in the construction sector. 展开更多
关键词 augmented reality human‑robot interaction interaction design human‑computer interaction literature review
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Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques 认领 引用
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作者 Qinyao Sun Shunli Zhu +6 位作者 Futing Yang Zhigang Chen Heling Li Heng Shao Hong Wang Sangma Xie Jiaojian Wang 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期91-106,共16页
The temporal pole(TP),one of the most expanded cortical regions in humans relative to other primates,plays a crucial role in human language processing.It is also one of the most structurally and functionally asymmetri... The temporal pole(TP),one of the most expanded cortical regions in humans relative to other primates,plays a crucial role in human language processing.It is also one of the most structurally and functionally asymmetric regions.However,whether the functional architecture of the TP is shared by humans and macaques is an open question.We used spectral clustering algorithms to define a cross-species fine-grained TP atlas with different anatomical connectivity patterns.We identified three similar subregions,two ventral and one dorsal,within the TP in both humans and macaques.The parcellation scheme for the TP was validated using functional gradient mapping,anatomical connectivity and resting-state functional connectivity pattern analysis,and functional characterization.Furthermore,in conjunction with the Allen Human Brain Atlas,we revealed the molecular basis for the functional connectivity patterns of each human TP subregion.In addition,we compared the hemispheric asymmetry in mean gray matter volume,anatomical connectivity fingerprints,and whole brain functional connectivity patterns to reveal the evolutionary differences in the TP and found different asymmetric patterns between humans and macaques.In conclusion,our findings reveal that the asymmetry in structure and connectivity may underpin the hemispheric functional specialization of the brain and provide a novel insight into understanding the evolutionary origin of the TP. 展开更多
关键词 Temporal pole Parcellation Asymmetry Evolution Human Macaque
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A robust nonfouling electrochemical biosensor with both filtering and antifouling strategies for cortisol detection in human blood 认领 引用
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作者 Xiujuan Qiao Rui Han +3 位作者 Xinru Xu Mingrui Lv Yiting Hou Xiliang Luo 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期456-461,共6页
The heavy biofouling on electrochemical sensor surface poses a formidable challenge for biosensing in human blood.Herein,we designed a multilayer filtering-sensing sandwich patch that served as a versatile platform to... The heavy biofouling on electrochemical sensor surface poses a formidable challenge for biosensing in human blood.Herein,we designed a multilayer filtering-sensing sandwich patch that served as a versatile platform to surmount the substantial fouling constraints for detection in human blood.The patch integrated two functional layers:(i) Inspired by dialysis phenomenon,a filtering-mass transfer hydrophilic membrane with heterogeneous nanostructure was used to filter large-size substances(like cells,bacteria and microorganisms,etc.) and continuously pass through the rest of the biological fluid(like proteins,metabolites and inorganic salts,etc.).(ii) the polypeptide composite hydrogel(r GO/PEPG) on the screenprinted electrode(SPE) surface,with the modulation of-COOH and-NH_2 groups,endowed a strong hydrophilic layer with electric neutrality to further facilitate the antifouling ability.Notably,the integration of the filtering porous membrane with the antifouling hydrogel ensures the strong antifouling ability of the electrochemical sensor in complex human blood.Furthermore,the self-healing property of the r GO/PEPG,relying on the physical π-π stacking forces,aligns the electrochemical sensor with practical needs.The constructed antifouling biosensor based on the filtering-sensing sandwich patch was successfully applied for the sensitive detection of cortisol in human blood,with an acceptable accuracy comparable to the enzyme-linked immunosorbent assay(ELISA) method.The strategy presented herein represent a promising advance along the road to construct effective antifouling biosensing devices with robust operation in diverse complex body fluids. 展开更多
关键词 Nonfouling Electrochemical biosensor Size-sieving Polypeptide complex hydrogel Cortisol Human blood
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Distribution and influencing factors of soil and groundwater pollution at pharmaceutical sites in China 认领 引用
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作者 Ying Hou Yi Shi +10 位作者 Weiguang Zhao Yifei Liu Nuchao Xu Hongxia Hu Haoyuan Wang Meng Yu Bochao Zhang Guizhen Hao Hongguang Zheng Juejun Yao Aizhong Ding 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期690-699,共10页
Owing to the rapid development of the pharmaceutical industry in China,contamination at legacy sites has become a major challenge that threatens the ecological environment and human health.Despite this growing concern... Owing to the rapid development of the pharmaceutical industry in China,contamination at legacy sites has become a major challenge that threatens the ecological environment and human health.Despite this growing concern,the distribution characteristics of contaminants at these legacy sites remain unclear.Therefore,we conducted a systematic analysis of the distribution characteristics,influencing factors,and health risks of soil and groundwater pollution at the legacy sites of 21 pharmaceutical enterprises.The results obtained identified heavy metals(As,Hg,and Pb),volatile organic compounds(VOCs)(benzene and trichloromethane),semi-volatile organic compounds(SVOCs)(benzo[a]pyrene),and inorganic salts(ammonia nitrogen and fluoride)as the major contaminants at the legacy sites.Heavy metals were primarily distributed in fill and clay layers,while the distribution of VOCs,which showed stronger vertical migration,was more diverse.Additionally,the vertical distribution pattern of the pollutants was primarily influenced by their production history,physicochemical properties,and site hydrogeological conditions.Via health risk assessment,As,Hg,and benzene were identified as major pollutants in terms of carcinogenic and non-carcinogenic risks,with the carcinogenic and non-carcinogenic(HI)risks of As(maximum value 2.97×10-3)and benzene(HI up to 10,200)significantly exceeding acceptable levels.Human exposure pathways included soil ingestion,air inhalation,and dermal contact.Overall,these findings serve as a reference for decision-making in risk identification and the development of pollution management and remediation strategies for legacy sites in the pharmaceutical industry. 展开更多
关键词 Pharmaceutical sites Soil-groundwater Vertical distribution Influencing factors Human health risks
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Land cover change and its influencing factors in the Southeast Xizang Autonomous Region,China 认领 引用
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作者 ZHANG Binghua LIU Linshan +5 位作者 ZHANG Yili WEI Bo QI Huxiao GONG Dianqing GU Changjun LI Lanhui 《Journal of Mountain Science》 SCIE CSCD 2026年第4期1702-1723,共22页
Persistent cloud cover and limited data availability hinder the understanding of land cover dynamics on the Southeast Xizang Autonomous Region,China.Existing studies often focus on subregions or specific land cover ty... Persistent cloud cover and limited data availability hinder the understanding of land cover dynamics on the Southeast Xizang Autonomous Region,China.Existing studies often focus on subregions or specific land cover types,lacking longterm,region-wide assessments of change and its influencing factors.To address this gap,we integrated dense Landsat time series with the Continuous Change Detection and Classification(CCDC)algorithm,to track land cover changes from 1990 to 2020.We further analyzed vegetation trends during 2000-2020 using Normalized Difference Vegetation Index(NDVI)in combination with Sen’s slope estimator.Subsequently,by integrating topographical(elevation,slope,aspect),climatic(precipitation,temperature,radiation),anthropogenic and other indicators,we employed the GeoDetector model to explore the influencing factors of land cover changes.The results showed that:(1)Land cover changed by 7.52%,with increases in cropland,forest,grassland,shrubland,and built-up land,and decreases in bareland,wetland,water bodies,and snow/ice.Bareland,cropland,and forest showed contrasting trends in the north and south;(2)NDVI increased overall(0.0008/a),with a higher growth rate in the south(0.0012/a)than in the north(0.0005/a);(3)For the three main land cover types(forest,shrubland,cropland),soil type and precipitation exhibited relatively higher explanatory power in the north,whereas in the south—with abundant moisture and strong elevation gradients—elevation and temperature played greater roles;(4)Human activities showed contrasting associations.In the north,areas with higher human activity(i.e.population density,light intensity)tended to coincide with forest expansion,and the proportion of significant NDVI increases was higher in these areas,which may largely reflect the effects of ecological restoration programs.The densely populated southern areas were more frequently associated with NDVI declines and forest degradation,driven by population growth and traditional farming practices.These findings highlight the spatial heterogeneity of land cover influencing factors and provide insights for sustainable land management and conservation in the region. 展开更多
关键词 Influencing factors GeoDetector Land cover change Himalaya Landsat Human activities
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Temperature and ethanol synergistically enhance microplastic release from disposable cups:mechanistic insights and health risk assessment of typical plastics 认领 引用
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作者 Simin Li Linzhen Yang +3 位作者 Xin Meng Wanchen Sun Hongzheng Zhang Jingru Yang 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第4期49-61,共13页
Disposable plastic cups used to hold beverages can release microplastics(MPs)that pose a potential risk to human health.In this study,the release of MPs from polypropylene(PP),polyethylene terephthalate(PET),and polys... Disposable plastic cups used to hold beverages can release microplastics(MPs)that pose a potential risk to human health.In this study,the release of MPs from polypropylene(PP),polyethylene terephthalate(PET),and polystyrene(PS)cups was systematically investigated under simulated realworld conditions by varying the temperature(20,40,and 70℃),contact time(30,60,and 120 min),and food simulants(4%acetic acid,10%ethanol,50%ethanol).The experimental results demonstrate that the highest temperature(70℃)and longest exposure(120 min)caused a significant increase in MPs release,with PS cups showing the highest level(1281.33±27.23 particles/L),particularly in 50%ethanol food simulant.Scanning electron microscopy(SEM)revealed the formation of surface cracks and protuberances after thermal treatment,while attenuated total reflectance fourier transform infrared spectroscopy(ATR-FTIR)indicates that the most pronounced chemical alterations in PS.Based on typical consumer behavior,we estimate that adults could ingest up to 6916–66612 MPs particles annually from disposable cups.These results indicating the interplay between cup material,usage conditions,and MPs release mechanisms suggest avoiding prolonged storage of hot liquids in PS containers to mitigate health risks. 展开更多
关键词 Disposable plastic cups Microplastics Food simulants Human health
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