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The role of immune cells in mediating the effects and prognosis of lipidome in ER+breast cancer:A mendelian randomization study 认领 引用
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作者 Fenyan Chen Congting Hu +6 位作者 Pingping Peng Ziming Cai Suyan Liu Jia Liu Jiaqin Cai Xiaoxia Wei Hong Sun 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2026年第6期560-573,共14页
Previous studies have suggested a potential interplay between the lipidome and immune cell dynamics in the development of estrogen receptor-positive(ER+)breast cancer(BC);however,the causal contribution of specific li... Previous studies have suggested a potential interplay between the lipidome and immune cell dynamics in the development of estrogen receptor-positive(ER+)breast cancer(BC);however,the causal contribution of specific lipid species and their potential mediation through immune cells remain poorly defined.To address this gap,the present study leveraged large-scale genome-wide association study(GWAS)data covering 179 lipid species.Two-sample Mendelian randomization(TSMR)was employed as the primary analytical framework to systematically evaluate the causal effects of diverse molecular lipid subtypes on ER+BC risk,as well as on short-term(5-year)and long-term(15-year)survival outcomes.The robustness of the primary causal estimates was further examined using Bayesian weighted Mendelian randomization(BWMR),alongside comprehensive sensitivity analyses,including formal assessments of heterogeneity and horizontal pleiotropy.Our analyses revealed that several lipid classes,most notably diacylglycerol,phosphatidylcholine,phosphatidylethanolamine,phosphatidylinositol,and triacylglycerol,exerted significant causal effects on both ER+BC susceptibility and patient survival.In addition,29 immune cell phenotypes were identified as being associated with prognosis,among which five emerged as potential key mediators linking lipid metabolism to ER+BC survival.Collectively,these findings provided robust genetic evidence supporting a causal role of the lipidome in the pathogenesis and progression of ER+BC,with this effect appearing to be partially mediated by specific immune cell populations. 展开更多
关键词 ER+BC Lipidome Immune cell Mendelian randomization
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Immune cells:potential carriers or agents for drug delivery to the central nervous system 认领 引用 被引量：7
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作者 Shan-Shan Zhang Ruo-Qi Li +3 位作者 Zhong Chen Xiao-Ying Wang Aaron S.Dumont Xiang Fan 《Military Medical Research》 SCIE CAS CSCD 2025年第1期121-153,共33页
Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery.However,the access of nanoparticles/drugs to the central nervous system(CNS)re... Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery.However,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain barriers.Immune cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug delivery.Herein,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain barrier.We subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS diseases.Finally,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development. 展开更多
关键词 Drug delivery systems Immune cells Blood-brain barrier Central nervous system
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Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration 认领 引用 被引量：1
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作者 Hui Xu Lining Cao +6 位作者 Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第12期3635-3648,共14页
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investiga... Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate the cell heterogeneity and interactions of MG and immune cells in the regenerating zebrafish retina.We first showed that two types of quiescent MG(resting MG1 and MG2)reside in the uninjured retina.Following retinal injury,resting MG1 transitioned into an activated state expressing known reprogramming genes,while resting MG2 gave rise to rod progenitors.We further showed that retinal microglia can be categorized into three subtypes(microglia-1,microglia-2,and proliferative)and pseudotime analysis demonstrated dynamic changes in microglial status following retinal injury.Analysis of cell–cell interactions indicated extensive crosstalk between immune cells and MG,with many interactions shared among different immune cell types.Finally,we showed that inflammation activated Jak1–Stat3 signaling in MG,promoting their transition from a resting to an activated state.Our study reveals the cell heterogeneity and crosstalk of immune cells and MG in zebrafish retinal repair,and may provide valuable insights into future mammalian retina regeneration. 展开更多
关键词 immune cells inflammation Jak1-Stat3 signaling microglia Müller glia regeneration reprogramming retina single-cell RNAseq zebrafish
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Immune cells in metabolic associated fatty liver disease:Global trends and hotspots(2004-2024) 认领 引用 被引量：1
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作者 Wen-Ying Qi Shi-Hao Zheng +8 位作者 Si-Ze Li Wei Wang Qiu-Yue Wang Qi-Yao Liu Xiao-Ke Li Jia-Xin Zhang Da-Nan Gan Yong-An Ye Xiao-Bin Zao 《World Journal of Hepatology》 2025年第3期208-224,共17页
BACKGROUND The interplay between immune cells and metabolic associated fatty liver disease(MAFLD)is a critical research frontier,bridging immunology and hepatology.The bibliometric findings can guide future research a... BACKGROUND The interplay between immune cells and metabolic associated fatty liver disease(MAFLD)is a critical research frontier,bridging immunology and hepatology.The bibliometric findings can guide future research and funding priorities in the field by highlighting key areas of focus and potential therapeutic targets.AIM To analyze the literature on immune cells and MAFLD,identifying research trends and future hotspots.METHODS A systematic search in the Web of Science Core Collection from January 1,2004 to May 20,2024,yielded 1936 articles on immune cells and MAFLD.Excluding nonresearch documents,the data were analyzed using R packages Cluster profiler,enrichplot,ggplot2,VOSviewer and CiteSpace.Visualizations were created for countries,institutions,authors,journals,fields,co-cited references,keywords,genes,and diseases,with gene a disease data from Citexs.RESULTS The field gained momentum in 2006,with the United States of America and China as leading contributors.Key research themes included oxidative stress,metabolic syndrome,liver fibrosis,and the role of Kupffer cells.Bioinformatics identified interleukin-6,tumor necrosis factor and signal transducer and activator of transcription 3 as central proteins in immune responses and inflammation,suggesting potential therapeutic targets for MAFLD.Clinically,these hub genes play pivotal roles in the pathogenesis of MAFLD.For instance,targeting the tumor necrosis factor signaling pathway could reduce inflammation,while modulating interleukin-6 and signal transducer and activator of transcription 3 expression may improve metabolic function,offering new strategies for MAFLD therapy.CONCLUSION This bibliometric analysis reports on the research hotspots and emerging trends in the field of immune cells and MAFLD,highlighting key proteins and potential therapeutic strategies through bioinformatics. 展开更多
关键词 Bibliometrics Global research effort Immune cells Metabolic associated fatty liver disease Research trends
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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance 认领 引用 被引量：3
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作者 Xiaojie Gan Jian Gu +1 位作者 Zheng Ju Ling Lu 《Engineering》 SCIE EI CAS CSCD 2022年第3期44-56,共13页
Organ transplant rejection(OTR)is a complex immune reaction involving multiple cells,and it determines graft survival and patient prognosis.At present,most transplant recipients are administered a combination of immun... Organ transplant rejection(OTR)is a complex immune reaction involving multiple cells,and it determines graft survival and patient prognosis.At present,most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from OTR.However,immunosuppressive agents negatively impact the immune system of the patients,causing them to suffer from serious complications,such as chronic infection and malignant tumors.Therefore,a thorough understanding of the mechanisms involved in immune tolerance and immune rejection with regard to organ transplant(OT)is essential for developing better treatment options and improving patient outcomes.This article reviews the role of immune cells in OTR and organ transplant tolerance(OTT),including the novel cell therapies that are currently under clinical trials for transplant recipients. 展开更多
关键词 Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance
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Exploring and validating genetic associations between immune cells and breast cancer 认领 引用
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作者 Jian-Ying Pei Chun Zhang +3 位作者 Jing-Ting Liu Chong Zhang Yi Wang Yan Li 《Cancer Advances》 2025年第24期1-13,共13页
Background:Observational epidemiology studies suggested the crucial role of immune cells in breast cancer(BC)development.The causalities of immunophenotypes with BC remain ambiguous.Methods:We performed a two-sample M... Background:Observational epidemiology studies suggested the crucial role of immune cells in breast cancer(BC)development.The causalities of immunophenotypes with BC remain ambiguous.Methods:We performed a two-sample Mendelian randomization(MR)analysis to investigate the potential causalities between immunophenotype traits and BC,and validated the findings using the flow-cytometry data of lymphocytes from a case-control study.The genome-wide association studies(GWAS)data on immunological traits were taken from a public catalog for 731 immunophenotypes,and the GWAS data in 6 cohorts of BC,which included malignant neoplasm of breast and carcinoma in situ of breast,were retrieved from the FinnGen database.The case-control study was conducted at Gansu Provincial Maternity and Child Care Hospital from January 2024 to May 2025,and included 123 BC patients and 109 healthy controls.Results:After investigating genetically predicted immunophenotype biomarkers,we discovered 24 highly correlated immunophenotypes and 83 suggestive possible factors.The case-control study effectively confirmed the differences in absolute count,relative count,and MFI in some highly correlated lymphocytes between BC patients and healthy controls.The study underscored that the absolute counts of lymphocytes,T cells,and CD45RA+CD8br are related to a reduced risk of BC,but CCR7 on naive CD8br showed a promoting effect on the pathogenesis of BC.Conclusion:Our findings demonstrate a complex genetic predisposition linking immunophenotypes to BC and provide preliminary experimental support.This study highlights potential avenues for immunotherapy but warrants further validation in larger,multi-ethnic cohorts. 展开更多
关键词 breast cancer immune cells mendelian randomization case-control study causality
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Liver infiltration of multiple immune cells during the process of acute liver injury and repair 认领 引用 被引量：7
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作者 Yuan Xie Ke-Bo Zhong +7 位作者 Yang Hu Yong-Lun Xi Shi-Xing Guan Meng Xu Yuan Lin Feng-Yong Liu Wei-Jie Zhou Yi Gao 《World Journal of Gastroenterology》 SCIE CAS 2022年第46期6537-6550,共14页
BACKGROUND Immune cells,including neutrophils,natural killer(NK)cells,T cells,NKT cells and macrophages,participate in the progression of acute liver injury and hepatic recovery.To date,there has been no systematic st... BACKGROUND Immune cells,including neutrophils,natural killer(NK)cells,T cells,NKT cells and macrophages,participate in the progression of acute liver injury and hepatic recovery.To date,there has been no systematic study on the quantitative changes in these different immune cells from initial injury to subsequent recovery.AIM To investigate the infiltration changes of various immune cells in acute liver injury models over time,and to study the relationship between the changes in leukocyte cellderived chemotaxin 2(LECT2)and the infiltration of several immune cells.METHODS Carbon tetrachloride-and concanavalin A-induced acute liver injury models were employed to mimic toxin-induced and autoimmune-mediated liver injury respectively.The quantitative changes in various immune cells were monitored at different time points.Serum samples were collected,and liver tissues were harvested.Ly6G,CD161,CD4,CD8 and F4/80 staining were used to indicate neutrophils,NK/NKT cells,CD4+T cells,CD8+T cells and macrophages,respectively.Lect2-KO mice were used to detect the function of LECT2.RESULTS During the injury and repair process,different types of immune cells began to increase,reached their peaks and fell into decline at different time points.Furthermore,when the serum alanine transaminase(ALT)and aspartate transaminase(AST)indices reverted to normal levels 7 d after the injury,the infiltration of immune cells still existed even 14 d after the injury,showing an obvious lag effect.We found that the expression of LECT2 was upregulated in acute liver injury mouse models,and the liver injuries of Lect2-KO mice were less severe than those of wild-type mice.Compared with wild-type mice,Lect2-KO mice had different immune cell infiltration.CONCLUSION The recovery time of immune cells was far behind that of serum ALT and AST during the process of liver repair.LECT2 could regulate monocyte/macrophage chemotaxis and might be used as a therapeutic target for acute liver injury. 展开更多
关键词 Immune cells Liver injury Liver repair Leukocyte cell-derived chemotaxin 2
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Roles of liver innate immune cells in nonalcoholic fatty liver disease 认领 引用 被引量：37
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作者 Yu-Tao Zhan Wei An 《World Journal of Gastroenterology》 SCIE CAS 2010年第37期4652-4660,共9页
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the United States and other developed countries and is expected to increase in the next few years. Emerging data suggest that some p... Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the United States and other developed countries and is expected to increase in the next few years. Emerging data suggest that some patients with NAFLD may progress to nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. NAFLD can also promote the development and progression of disease in other organ systems, such as the cardiovascular and endocrine (i.e. diabetes) systems. Thus, understanding the pathogenesis of NAFLD is of great clinical importance and is critical for the prevention and treatment of the disease. Although the "two-hit hypothesis" is generally accepted, the exact pathogenesis of NAFLD has not been clearly established. The liver is an important innate immune organ with large numbers of innate immune cells, including Kupffer cells (KCs), natural killer T (NKT) cells and natural killer (NK) cells. Recent data show that an imbalance in liver cytokines may be implicated in the development of fatty liver disease. For example, Th1 cytokine excess may be a common pathogenic mechanism for hepatic insulin resistance and NASH. Innate immune cells in the liver play important roles in the excessive production of hepatic Th1 cytokines in NAFLD. In addition, liver innate immune cells participate in the pathogenesis of NAFLD in other ways. For example, activated KCs can generate reactive oxygen species, which induce liver injury. This review will focus primarily on the possible effect and mechanism of KCs, NKT cells and NK cells in the development of NAFLD. 展开更多
关键词 Innate immune cells Nonalcoholic fatty liver disease Kupffer cell Natural killer T cell Natural killer cell
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The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma 认领 引用 被引量：3
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作者 Jian Wang Fan Yang +9 位作者 Qian Sun Ziqing Zeng Min Liu Wenwen Yu Peng Zhang Jinpu Yu Lili Yang Xinwei Zhang Xiubao Ren Feng Wei 《Cancer Biology & Medicine》 SCIE CAS CSCD 2021年第4期1134-1147,共14页
Objective:Patients with non–small cell lung cancer(NSCLC)respond differently to cytokine-induced killer cell(CIK)treatment.Therefore,potential prognostic markers to identify patients who would benefit from CIK treatm... Objective:Patients with non–small cell lung cancer(NSCLC)respond differently to cytokine-induced killer cell(CIK)treatment.Therefore,potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated.The current research aimed at identifying predictive prognostic markers for efficient CIK treatment of patients with NSCLC.Methods:Patients histologically diagnosed with NSCLC were enrolled from the Tianjin Medical University Cancer Institute and Hospital.We performed whole-exome sequencing(WES)on the tumor tissues and paired adjacent benign tissues collected from 50 patients with NSCLC,and RNA-seq on tumor tissues of 17 patients with NSCLC before CIK immunotherapy treatment.Multivariate Cox proportional hazard regression analysis was used to analyze the association between clinical parameters and prognostic relevance.WES and RNA-seq data between lung squamous cell carcinoma(SCC)and adenocarcinoma(Aden)were analyzed and compared.Results:The pathology subtype of lung cancer was the most significantly relevant clinical parameter associated with DFS,as analyzed by multivariate Cox proportional hazard regression(P=0.031).The patients with lung SCC showed better CIK treatment efficacy and extended DFS after CIK treatment.Relatively low expression of HLA class II genes and checkpoint molecules,and less immunosuppressive immune cell infiltration were identified in the patients with lung SCC.Conclusions:Coordinated suppression of the expression of HLA class II genes and checkpoint molecules,as well as less immune suppressive cell infiltration together contributed to the better CIK treatment efficacy in lung SCC than lung Aden. 展开更多
关键词 NSCLC CIK treatment DFS HLA class II infiltrating immune cells
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Atherosclerosis and the role of immune cells 认领 引用 被引量：15
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作者 Fulya Ilhan Sevgi Tas Kalkanli 《World Journal of Clinical Cases》 SCIE 2015年第4期345-352,共8页
Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monoc... Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis. 展开更多
关键词 Atherosclerosis Inflammatory cytokines Pro-inflammatory mediators Immune cells Adhesion molecules
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Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate 认领 引用 被引量：2
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作者 Qi-Liang Teng Xin-Rui Yang +6 位作者 Shuang Wen Zhi-Hong Dai Hong-Long Wang Tian-Qing Liu Liang Wang Bo Fan Zhi-Yu Liu 《Asian Journal of Andrology》 SCIE CAS CSCD 2022年第5期525-532,共8页
Primary signet ring cell carcinoma(SRCC)of the prostate is a rare neoplasm.However,its potential tumorigenic mechanism,clinicopathological features,and prognostic outcome have not been systematically described.To dete... Primary signet ring cell carcinoma(SRCC)of the prostate is a rare neoplasm.However,its potential tumorigenic mechanism,clinicopathological features,and prognostic outcome have not been systematically described.To determine the pathogenic mechanism,we detected distributions of programmed cell death-ligand 1(PD-L1),programmed death 1(PD-1),and cellular components in the tumor microenvironment,including tumor-infiltrating lymphocytes(CD4 and CD8),tumor-associated macrophages(TAMs;CD163 and CD68),and tumor-associated fibroblasts(vimentin and alpha-smooth muscle actin[α-SMA]),in tumor tissues from four patients with primary prostatic SRCC compared with corresponding adjacent tissues and tumor tissues from 30 patients with prostate adenocarcinoma(PCa)by immunohistochemical staining.We found higher expression of PD-L1,CD163,and CD68 in primary SRCC specimens than that in both corresponding adjacent nontumor specimens and PCa specimens with different Gleason scores,indicating that TAMs may participate in the malignant biological behavior of primary SRCC of the prostate.For further analysis,we searched electronic journal databases and Surveillance,Epidemiology,and End Results(SEER)to identify 200 eligible patients including our four cases.According to Kaplan–Meier survival curve analysis,patients<68 years old,with radical prostatectomy(RP),Gleason score of 7–8,and lower clinical stage had longer overall survival(OS).Moreover,Cox multivariate analysis indicated that race(hazard ratio[HR]=1.422),surgical approach(HR=1.654),and Gleason score(HR=2.162)were independent prognostic factors for OS.Therefore,primary SRCC of the prostate represents a distinct and aggressive subtype of prostate cancer associated with a higher distribution of PD-L1 and TAMs,which warrants further clinical investigation. 展开更多
关键词 clinical features immunohistochemistry infiltrating immune cells primary signet ring cell carcinoma of the prostate tumor microenvironment
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Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells,rather than tumor cells in the breast cancer microenvironment 认领 引用
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作者 Rui-Bin Wang Yu-Chen Li +6 位作者 Quan Zhou Shu-Zhen Lv Ke-Yu Yuan Jiang-Ping Wu Yan-Jie Zhao Qing-KunSong Bin Zhu 《World Journal of Clinical Cases》 SCIE 2020年第23期5935-5943,共9页
BACKGROUND CD155 is an immune checkpoint protein in cancers and interacts with ligands to regulate the immune microenvironment.The expression of CD155 is correlated with the prognosis and pathological features of brea... BACKGROUND CD155 is an immune checkpoint protein in cancers and interacts with ligands to regulate the immune microenvironment.The expression of CD155 is correlated with the prognosis and pathological features of breast cancer.AIM To investigate the expression status of CD155 and the association with exhausted CD4+helper and CD8+cytotoxic tumor infiltrating lymphocytes(TILs)and PD-L1 in the breast cancer microenvironment.METHODS One hundred and twenty-six breast cancer patients with invasive ductal breast cancer were consecutively recruited into this study.Immunohistochemistry was used to detect the expression CD155,PD-L1 and PD-1 on tumor-infiltrating immune cells and tumor cells in the microenvironment.RESULTS The proportion of patients with CD155 expression was higher in triple negative breast cancer(72.7%)than in Luminal A patients(22.2%,P<0.05).Patients with positive CD155 expression had a higher percentage of CD4+/PD-1+helper TILs(30%)than patients with negative CD155 expression(21%,P<0.05).Patients with positive CD155 expression also had higher cell counts of exhausted CD4+TILs[47 vs 20/high-power fields(HPF)]and unexhausted CD8+TILs(30 vs 17/HPF)than patients with negative expression(P<0.05).CD155 expression was correlated with increased PD-L1 expression in immune cells,0.8%and 0.02%immune cells expressed PD-L1 in patients with positive and negative CD155 expression,respectively(P<0.05).CONCLUSION CD155 was related to an inhibitory immune breast cancer microenvironment.CD155 was associated with a high proportion of exhausted CD4+and unexhausted CD8+TILs and high PD-L1 expression in immune cells. 展开更多
关键词 Breast cancer CD155 PD-1 PD-L1 Tumor-infiltrating lymphocytes Immune cells
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Facing challenges with hope:universal immune cells for hematologic malignancies 认领 引用 被引量：5
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作者 Yuqing Wang Ruihao Huang +3 位作者 Zheng Wang Jingkang Xiong Xiaoqi Wang Xi Zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2023年第4期229-247,共19页
Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host d... Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation(allo-HSCT)has been widely implemented to treat hematologic malignancies.However,graft-versus-host disease(GVHD)and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life.In addition,GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions(DLIs)and chimeric antigen receptor(CAR)T-cell therapy.Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells,universal immune cell therapy may strongly reduce GVHD,while simultaneously reducing tumor burden.Nevertheless,widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy.Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy,including the use of universal cell lines,signaling regulation and CAR technology.In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives. 展开更多
关键词 Universal immune cells graft-versus-host disease immune tolerance chimeric antigen receptor
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The role of innate immune cells as modulators of the tumor microenvironment in the metastasis and treatment of pancreatic cancer 认领 引用 被引量：2
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作者 Tianyi Zhu Xiuqi Wu +4 位作者 Yuan Liao Yidan Yan Minhao Yu Liwei Wang Qing Xia 《Clinical Cancer Bulletin》 2023年第1期26-42,共17页
Pancreatic cancer is a highly aggressive disease,which is often diagnosed late.Consequently,metastasis is common among newly diagnosed patients,leading to a poor prognosis and high mortality rates.The tumor microenvir... Pancreatic cancer is a highly aggressive disease,which is often diagnosed late.Consequently,metastasis is common among newly diagnosed patients,leading to a poor prognosis and high mortality rates.The tumor microenvironment of pancreatic cancer,which comprises pancreatic cancer cells,stromal cells,and immune cells,as well as a multitude of extracellular components,plays a pivotal role in cancer progression and metastasis.Conventional immunotherapies focused on targeting the adaptive immune response have achieved suboptimal outcomes in patients with pancreatic cancer.Thus,the focus has shifted toward targeting innate immune cells,which can infiltrate the pancreatic tumor and contribute to the development and maintenance of the immunosuppressive microenvironment to promote tumor growth and metastasis.This review focuses on the roles of innate immune cells and their interactions in the shaping of an immunosuppressive tumor microenvironment to promote the metastasis of pancreatic cancer.In addition,we review strategies that target innate immune cells to remodel the immunosuppressive tumor microenvironment and improve the prognosis of pancreatic cancer. 展开更多
关键词 Pancreatic cancer Tumor microenvironment Immune cells Metastasis
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Tail regeneration reduction in lizards after repetitive amputation or cauterization reflects an increase of immune cells in blastemas 认领 引用 被引量：2
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作者 Lorenzo Alibardi 《Zoological Research》 SCIE CSCD 2018年第6期413-423,共11页
Lizards are key amniote models for studying organ regeneration. During tail regeneration in lizards, blastemas contain sparse granulocytes, macrophages, and lymphocytes among the prevalent mesenchymal cells. Using tra... Lizards are key amniote models for studying organ regeneration. During tail regeneration in lizards, blastemas contain sparse granulocytes, macrophages, and lymphocytes among the prevalent mesenchymal cells. Using transmission electron microscopy to examine scarring blastemas after third and fourth sequential tail amputations, the number of granulocytes, macrophages, and lymphocytes increased at 3-4 weeks in comparison to the first regeneration. An increase in granulocytes and agranulocytes also occurred within a week after blastema cauterization during the process of scarring Blood at the third and fourth regeneration also showed a significant increase in white blood cells compared with that under normal conditions and at the first regeneration. The extracellular matrix of the scarring blastema, especially after cauterization, was denser than that in the normal blastema and numerous white blood cells and fibroblasts were surrounded by electron-pale, fine fibrinoid material mixed with variable collagen fibrils. In addition to previous studies, the present observations support the hypothesis that an increase in inflammation and immune reactions determine scarring rather than regeneration. These new findings verify that an immune reaction against mesenchymal and epidermal cells of the regenerative blastema is one of the main causes for the failure of organ regeneration in amniotes. 展开更多
关键词 Lizard Tail Repetitive regeneration Blood Immune cells Ultrastructure
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Metabolic Homeostasis of Immune Cells Modulates Cardiovascular Diseases 认领 引用 被引量：1
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作者 Mohan Li Xiaolei Sun +2 位作者 Linqi Zeng Aijun Sun Junbo Ge 《Research》 SCIE EI CSCD 2026年第1期385-396,共12页
Recent investigations into the mechanisms underlying inflammation have highlighted the pivotal role of immune cells in regulating cardiac pathophysiology.Notably,these immune cells modulate cardiac processes through a... Recent investigations into the mechanisms underlying inflammation have highlighted the pivotal role of immune cells in regulating cardiac pathophysiology.Notably,these immune cells modulate cardiac processes through alternations in intracellular metabolism,including glycolysis and oxidative phosphorylation,whereas the extracellular metabolic environment is changed during cardiovascular disease,influencing function of immune cells.This dynamic interaction between immune cells and their metabolic environment has given rise to the novel concept of“immune metabolism”.Consequently,both the extracellular and intracellular metabolic environment modulate the equilibrium between anti-and pro-inflammatory responses.This regulatory mechanism subsequently influences the processes of myocardial ischemia,cardiac fibrosis,and cardiac remodeling,ultimately leading to a series of cardiovascular events.This review examines how local microenvironmental and systemic environmental changes induce metabolic reprogramming in immune cells and explores the subsequent effects of aberrant activation or polarization of immune cells in the progression of cardiovascular disease.Finally,we discuss potential therapeutic strategies targeting metabolism to counteract abnormal immune activation. 展开更多
关键词 immune cellsthis metabolic homeostasis metabolic environment intracellular metabolismincluding extracellular metabolic environment immune cells cardiovascular diseases oxidative phosphorylationwhereas
Comprehensive insights into the effects and regulatory mechanisms of immune cells expressing programmed death-1/programmed death ligand 1 in solid tumors 认领 引用 被引量：11
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作者 Min Liu Qian Sun +1 位作者 Feng Wei Xiubao Ren 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第3期626-639,共14页
The programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)signaling pathway is an important mechanism in tumor immune escape,and expression of PD-L1 on tumor cells has been reported more frequently.Howeve... The programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)signaling pathway is an important mechanism in tumor immune escape,and expression of PD-L1 on tumor cells has been reported more frequently.However,accumulating evidence suggests that PD-1/PD-L1 is also widely expressed on immune cells,and that regulation is also critical for tumor immune responses.In this review,we emphasized that under solid tumor conditions,the immunoregulatory effects of immune cells expressing PD-1 or PD-L1,affected the prognoses of cancer patients.Therefore,a better understanding of the mechanisms that regulate PD-1 or PD-L1 expression on immune cells would provide clear insights into the increased efficacy of anti-PD antibodies and the development of novel tumor immunotherapy strategies. 展开更多
关键词 Immune cell immunotherapy programmed cell death ligand 1 programmed cell death-1 solid tumor
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Three-dimensional structure of liver vessels and spatial distribution of hepatic immune cells 认领 引用 被引量：2
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作者 Mengli Xu Zheng Liu +4 位作者 Xinlin Li Xinru Wang Xuenan Yuan Chenlu Han Zhihong Zhang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2023年第3期65-77,共13页
As the largest internal organ of the human body,the liver has an extremely complex vascularnetwork and multiple types of immune cells.It plays an important role in blood circulation,material metabolism,and immune resp... As the largest internal organ of the human body,the liver has an extremely complex vascularnetwork and multiple types of immune cells.It plays an important role in blood circulation,material metabolism,and immune response.Optical imaging is an effective tool for studying finevascular structure and immunocyte distribution of the liver.Here,we provide an overview of thestructure and composition of liver vessels,the threedimensional(3D)imaging of the liver,andthe spatial distribution and immune function of various cell components of the liver.Especially,we emphasize the 3D imaging methods for visualizing fine structure in the liver.Finally,wesummarize and prospect the development of 3D imaging of liver vesels and immune cells. 展开更多
关键词 Liver blood vessel,immune cell 3D imaging
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Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells 认领 引用
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作者 Zhuo-Ran Wang Cun-Zhen Zhang +3 位作者 Zhan Ding Yi-Zhuo Li Jian-Hua Yin Nan Li 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第10期4092-4103,共12页
BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ineffective.Tumor-associated immune ce... BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ineffective.Tumor-associated immune cells are critical for tumor development and progression.The main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for ICC.AIM To establish 1-year and 3-year prognostic models for ICC after surgical resection.METHODS Immunohistochemical staining was performed for CD4,CD8,CD20,pan-cytokeratin(CK),and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative surgery.Selection of variables was based on regression diagnostic procedures and goodness-of-fit tests(PH assumption).Clinical parameters and pathological diagnoses,combined with the distribution of immune cells in tumors and paired adjacent tissues,were utilized to establish 1-and 3-year prognostic models.RESULTS This is an important application of immune cells in the tumor microenvironment.CD4,CD8,CD20,and CK were included in the establishment of our prognostic model by stepwise selection,whereas CD68 was not significantly associated with the prognosis of ICC.By integrating clinical data associated with ICC,distinct prognostic models were derived for 1-and 3-year survival outcomes using variable selection.The 1-year prediction model yielded a C-index of 0.7695%confidence interval(95%CI):0.65-0.87 and the 3-year prediction model produced a C-index of 0.69(95%CI:0.65-0.73).Internal validation yielded a C-index of 0.761(95%CI:0.669-0.853)for the 1-year model and 0.693(95%CI:0.642-0.744)for the 3-year model.CONCLUSION We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection,which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment and immune cell changes in the future. 展开更多
关键词 Intrahepatic cholangiocarcinoma Tumor immune cells Biomarkers Prognosis Prediction models
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Comprehensive assessment of the association between tumorinfiltrating immune cells and the prognosis of renal cell carcinoma 认领 引用 被引量：1
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作者 Guo-Hao Wei Xi-Yi Wei +3 位作者 Ling-Yao Fan Wen-Zheng Zhou Ming Sun Chuan-Dong Zhu 《World Journal of Clinical Oncology》 2024年第10期1280-1292,共13页
BACKGROUND According to current statistics,renal cancer accounts for 3%of all cancers world-wide.Renal cell carcinoma(RCC)is the most common solid lesion in the kidney and accounts for approximately 90%of all renal ma... BACKGROUND According to current statistics,renal cancer accounts for 3%of all cancers world-wide.Renal cell carcinoma(RCC)is the most common solid lesion in the kidney and accounts for approximately 90%of all renal malignancies.Increasing evi-dence has shown an association between immune infiltration in RCC and clinical outcomes.To discover possible targets for the immune system,we investigated the link between tumor-infiltrating immune cells(TIICs)and the prognosis of RCC.AIM To investigate the effects of 22 TIICs on the prognosis of RCC patients and iden-tify potential therapeutic targets for RCC immunotherapy.METHODS The CIBERSORT algorithm partitioned the 22 TIICs from the Cancer Genome Atlas cohort into proportions.Cox regression analysis was employed to evaluate the impact of 22 TIICs on the probability of developing RCC.A predictive model for immunological risk was developed by analyzing the statistical relationship between the subpopulations of TIICs and survival outcomes.Furthermore,multi-variate Cox regression analysis was used to investigate independent factors for the prognostic prediction of RCC.A value of P<0.05 was regarded as statistically significant.RESULTS Compared to normal tissues,RCC tissues exhibited a distinct infiltration of im-mune cells.An immune risk score model was established and univariate Cox regression analysis revealed a significant association between four immune cell types and the survival risk connected to RCC.High-risk individuals were correlated to poorer outcomes according to the Kaplan-Meier survival curve(P=1E-05).The immunological risk score model was demonstrated to be a dependable predictor of survival risk(area under the curve=0.747)via the receiver operating characteristic curve.According to multivariate Cox regression analysis,the immune risk score model independently predicted RCC patients'prognosis(hazard ratio=1.550,95%CI:1.342–1.791;P<0.001).Finally,we established a nomogram that accurately and comprehensively forecast the survival of patients with RCC.CONCLUSION TIICs play various roles in RCC prognosis.The immunological risk score is an independent predictor of poor survival in kidney cancer cases. 展开更多
关键词 Renal cell carcinoma Tumor-infiltrating immune cells Prognosis Immune risk score model Nomogram
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