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Inflammatory bone loss and signaling pathways in periodontitis:mechanistic insights and emerging therapeutic strategies 认领 引用 被引量：1
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作者 Rafael Scaf de Molon Rolando Vernal +5 位作者 Gabriela Ezequiel Oliveira Joao Paulo Steffens Edilson Ervolino Leticia Helena Theodoro Jeroen J.J.Pvan den Beucken Sotirios Tetradis 《Bone Research》 SCIE CAS CSCD 2026年第1期1-27,共27页
Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation... Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation contributes to pathological conditions such as osteoporosis,rheumatoid arthritis,and periodontitis.Periodontitis is a highly prevalent chronic inflammatory disease driven by dysbiotic biofilms that disrupt the oral microbiome,leading to the progressive breakdown of the periodontal ligament,cementum,and alveolar bone and ultimately resulting in tooth loss.This review outlines the molecular and cellular mechanisms underlying periodontitis,focusing on osteoclastogenesis,the differentiation and activation of osteoclasts,the primary mediators of bone resorption.Key transcriptional regulators,including NFATc1,c-Fos,and c-Src are discussed alongside major signaling pathways such as Mitogen Activated Protein Kinase(MAPK),Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription(JAK/STAT),Nuclear Factor Kappa B(NF-κB),and Phosphoinositide 3-kinase(PI3K)/Akt,to elucidate their roles in the initiation and progression of periodontal bone loss.These pathways orchestrate the inflammatory response and osteoclast activity,underscoring their relevance in periodontitis and other osteolytic conditions.Hallmark features of periodontitis,including chronic inflammation,immune dysregulation,and tissue destruction are highlighted,with emphasis on current and emerging therapeutic strategies targeting these molecular pathways.Special attention is given to small molecules,biologics,and natural compounds that have the potential to modulate key signaling pathways.Although advances in understanding these mechanisms have identified promising therapeutic targets,translation into effective clinical interventions remains challenging.Continued research into regulating bone-resorptive signaling pathways is essential for developing more effective treatments for periodontitis and related inflammatory bone diseases. 展开更多
关键词 NFATc chronic inflammatory disease bone resorption inflammatory bone loss signaling pathways osteoclastogenesis periodontal ligamentcemen dysbiotic biofilms
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Decoding cellular communication networks and signaling pathways in bone,skeletal muscle,and bone-muscle crosstalk through spatial transcriptomics in a young male mouse 认领 引用 被引量：1
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作者 Chuan Qiu Yisu Li +16 位作者 Yun Gong William Sherman Di Tian Weiqiang Lin Zehui Pan Boluwatife Afolabi Vivek Thumbigere Kuanjui Su Jeffrey Deng Yuwei Hou Shashank Mungasavalli Gnanesh Zhe Luo Qing Tian Fernando Sanchez Yiping Chen Hui Shen Hong-Wen Deng 《Bone Research》 SCIE CAS CSCD 2026年第3期920-934,共15页
Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines... Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines,growth factors,and extracellular-matrix(ECM)proteins.The spatial organization of these mediators is critical for maintaining tissue integrity,and its disruption contributes to diseases,such as osteoporosis,sarcopenia,and metabolic syndrome.Despite this importance,spatial transcriptomics(ST)studies of bone-muscle interactions remain limited.Here,we applied 10x Genomics Visium ST with computational tools,e.g.,SMART and CellChat,to deconvolute cell-type composition and characterize cell-cell communication networks and ligand-receptor(L-R)interactions in mouse femur and adjacent skeletal muscle.We identified eight major cell types(erythroid cells,endothelial cells,skeletal muscle cells,osteoblasts,myeloid cells,monocytes/macrophages,mesenchymal stem cells,and adipocytes)with distinct spatial transcriptional profiles and thirteen CellChat-inferred pathways,such as ECM-receptor related(e.g.,COLLAGEN,TENASCIN,THBS)and secreted-signaling involved(e.g.,VEGF)pathways.Representative L-R pairs include Col1a1/Col1a2-Sdc4,mediating osteoblast-to-muscle interactions,and Col4a1-Sdc4,facilitating muscle-to-osteoblast interactions in COLLAGEN,Tnxb-Sdc4 in TENASCIN,supporting muscle-to-osteoblast/muscle/myeloid/endothelial communication,Comp-Sdc4 in THBS,driving monocyte/macrophage-to-osteoblast/muscle signaling,and Vegfa-Vegfr1/Vegfr2 in VEGF,mediating muscle-toendothelial/myeloid signaling.Immunostaining validated colocalization of several representative L-R pairs with their corresponding cells.Additionally,independent mouse and human bone scRNA-seq datasets reproduced most of the pathways and L-R pairs identified in ST,underscoring the robustness and cross-species relevance of our findings.Together,we present an initial spatially resolved transcriptome-wide map of bone-muscle intercellular communication,providing novel insights into molecular crosstalk and establishing groundwork for future studies in musculoskeletal disorders. 展开更多
关键词 skeletal muscle cells bone muscle crosstalk spatial transcriptomics osteoblasts signaling pathways young male mouse musculoskeletal systemenabling bone skeletal muscle
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Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways 认领 引用
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作者 Yu-Jiao Li Xi Chen +9 位作者 Yong-Yin Luo Jun Chang Shu-Zhen Liu Xiao-Qian Shan Jing-Jing Song Nan Hao Xu-He Yan Wei-Li Gao Jian-Wei Liu Lan Zhao 《World Journal of Stem Cells》 SCIE 2026年第3期93-115,共23页
BACKGROUND Neural stem cells(NSCs)transplantation is a promising clinical therapy for Alzheimer’s disease(AD).The Notch and Wnt signaling pathways play important roles in the biological functions of NSCs,and microRNA... BACKGROUND Neural stem cells(NSCs)transplantation is a promising clinical therapy for Alzheimer’s disease(AD).The Notch and Wnt signaling pathways play important roles in the biological functions of NSCs,and microRNA-124(miR-124)regulates these pathways through its regulatory effects.AIM To explore the mechanism of acupuncture in enhancing the function of transplanted NSCs and their therapeutic potential in AD.METHODS This study utilized enzyme-linked immunosorbent assay,western blotting,and real-time fluorescent quantitative polymerase chain reaction,to investigate the effects of acupuncture on the role of miR-124 in regulating the Notch and Wnt signaling pathways,in NSCs transplantation therapy in a mouse model of AD-senescence-accelerated mouse prone 8 mice.An in vitro coculture model of mouse hippocampal brain slices and NSCs was established,and flow cytometry was used to examine the effects of acupuncture on the regulation of cyclin D1,an interactive protein in the Notch and Wnt signaling pathways,and on NSCs proliferation and differentiation.RESULTS Acupuncture significantly improved cognitive impairment in AD mice after NSCs transplantation(P<0.05);inhibited expression of characteristic pathological biomarkers of AD(P<0.05);and upregulated expression of NSCs-specific neuroproliferation and differentiation biomarkers(P<0.05).Upregulation of miR-124 modulated the key target genes Notch homolog 1,hairy and enhancer of split 5,and glycogen synthase kinase 3βin the Notch and Wnt signaling pathways(P<0.05);regulated the Notch and Wnt dual signaling pathways and achieved interaction(P<0.05);promoted NSCs proliferation and differentiation(P<0.05);restored damaged cells;and slowed the progression of AD.CONCLUSION Acupuncture may improve the hippocampal microenvironment by upregulating miR-124 to regulate the Notch and Wnt dual signaling pathways,promote NSCs proliferation and differentiation,facilitate the repair of damaged neurons,integrate neural circuits,restore biological functions,and improve cognitive impairment in AD mice. 展开更多
关键词 Neural stem cells Hippocampal microenvironment Acupuncture MicroRNA-124 Notch signaling pathway Wnt signaling pathway Alzheimer’s disease
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Research progress on synthetic pyrethroid biodegradation:Current status,pathways,mechanisms and enzyme enhancement strategies 认领 引用
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作者 Jiarong QIU Jinzhi WU +2 位作者 Liangqing ZHANG Yaofa LUO Jianfeng CHEN 《Pedosphere》 SCIE CAS CSCD 2026年第1期25-38,共14页
Pyrethroids are a class of novel broad-spectrum pesticides synthesized to mimic natural pyrethrins.Due to their high efficiency,low toxicity,and safety,pyrethroids have been widely used as alternatives to organophosph... Pyrethroids are a class of novel broad-spectrum pesticides synthesized to mimic natural pyrethrins.Due to their high efficiency,low toxicity,and safety,pyrethroids have been widely used as alternatives to organophosphate and carbamate insecticides in the control of agricultural and sanitary pests.However,with the increasing use of pyrethroid pesticides,the resulting pesticide residues have posed threats to both the environment and human health.Biodegradation is considered one of the most promising methods for the removal of pyrethroids,and significant research has been conducted in this area.This review summarizes recent advances in the biodegradation of pyrethroids,including degradation by single strains,microbial consortia,and enzymes.It provides an in-depth analysis of the biodegradation pathways and catalytic mechanisms involved in the degradation of pyrethroids and outlines enhancement strategies for improving the activity of pyrethroid-degrading enzymes.The review also identifies current challenges in pyrethroid biodegradation and offers perspectives for future research.This review serves as a valuable reference for subsequent studies on pyrethroid biodegradation. 展开更多
关键词 catalytic mechanism degradation pathway insecticide microbial consortia pesticide pyrethroid-degrading enzyme
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Changes of bone remodeling,cartilage damage and apoptosis-related pathways in broilers with femoral head necrosis 认领 引用
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作者 Yaling Yu Hongfan Ge +3 位作者 Hang Gao Yanyan Zhang Kangping Liu Zhenlei Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期788-802,共15页
Femoral head necrosis(FHN) is a common leg disorder in the poultry industry often leads to significant cartilage damage.The mechanism behind abnormal apoptosis in FHN broilers,leading to cartilage damage,remains uncle... Femoral head necrosis(FHN) is a common leg disorder in the poultry industry often leads to significant cartilage damage.The mechanism behind abnormal apoptosis in FHN broilers,leading to cartilage damage,remains unclear;although endoplasmic reticulum stress(ERS) has been found to play a role in glucocorticoid-induced FHN broilers.In this study,we collected samples from broilers with femoral head separation(FHS) and femoral head separation accompanied with growth plate lacerations(FHSL) in a broiler farm.The aim was to investigate the potential association between the severity of FHN,bone remodeling and cartilage damage.Additionally,primary chondrocytes were treated with methylprednisolone(MP) to construct an in vitro FHN model,followed by inhibition or activation of ERS or hypoxia inducible factor-1α(HIF-1α) to further investigate the mechanism of apoptosis in cartilage.The results suggested that cartilage appeared to be the appropriate tissue to investigate the potential mechanisms of FHN,as the degree of cartilage damage was found to be closely related to the severity of the disease.Bone quality was only affected in FHSL broilers,although factors related to bone metabolism were significantly altered among FHN-affected broilers.In addition,cartilage in FHN-affected broilers exhibited high levels of apoptosis and upregulated expression of ERS-related and HIF-1α,which was consistent with both in vivo and in vitro findings after MP treatment.The results were further supported by treatment with HIF-1α or ERS inhibition or activation.In conclusion,bone remodeling and cartilage homeostasis were affected in FHN broilers,but only cartilage damage was significantly exacerbated with FHN development.Moreover,activation of ERS or HIF-1α resulted in apoptosis in cartilage,thus exhibiting a significant correlation with FHN severity. 展开更多
关键词 femoral head necrosis bone remodeling cartilage homeostasis apoptosis-related pathways
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Kaempferol protects against dexamethasone-induced muscle atrophy in mice by increasing PI3K/AKT/mTOR and NRF2/HO-1/KEAP1 signaling pathways:network pharmacology,molecular docking,and experimental validation studies 认领 引用
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作者 Ming Zhang Guofei Chang +6 位作者 Shouzheng Gao Jiuying Wei Minmin Chen Ling Song Juan Lu Jun Sheng Xiao Ma 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期851-868,共18页
Muscle atrophy can be induced by high doses or prolonged use of glucocorticoids.Kaempferol(Kae)is a naturally occurring flavonoid with a variety of biological activities and the effect of Kae on dexamethasone(Dex)indu... Muscle atrophy can be induced by high doses or prolonged use of glucocorticoids.Kaempferol(Kae)is a naturally occurring flavonoid with a variety of biological activities and the effect of Kae on dexamethasone(Dex)induced muscle atrophy in animals has not been elucidated.To explore this issue,the present experiments used a computationally assisted drug design scheme combining network pharmacology,molecular docking and in vivo experiments to investigate the mechanism of Kae against muscle atrophy.Network pharmacological analyses revealed 275 potential targets for Kae and 12294 potential targets for muscle atrophy,with a total of 228 crosstargets for Kae and muscle atrophy.GO and KEGG analyses were performed based on the protein-protein interaction(PPI)network of muscle atrophy and Kae component targets.The GO results showed that the biological processes were mainly related to the metabolic process of reactive oxygen species,and the response to oxidative stress;the cellular components were mainly focused on membrane microdomains,and membrane regions;the molecular functions mainly worked on phosphatase binding;and the KEGG pathway enrichment analyses identified the pathways of interaction between Kae and muscle atrophy.Finally,as verified by in vivo experiments,Kae may reduce the onset of muscle atrophy by activating the PI3K/AKT/m TOR/signalling pathway,inhibiting Foxo1/Foxo3 activity,and inhibiting downstream production of the ubiquitination 3 ligases Atrogin1 and Mu RF1;Kae also promotes the expression of NRF2/HO-1/KEAP1 signalling pathway,enhances muscle antioxidant capacity,inhibits the release of COX-2 and TNF-αinflammatory factors,and reduces the damage caused by oxidative stress and inflammatory factors to muscles.Therefore,there may be a synergistic effect of PI3K/AKT/m TOR and NRF2/HO-1/KEAP1 in Kae working together to prevent muscle atrophy.The binding energy and stability of Kae to potential targets were examined by molecular docking and molecular dynamics simulations,implying that Kae could be used for the prevention and treatment of muscle atrophy in patients. 展开更多
关键词 Kaempferol Dexamethasone Muscle atrophy PI3K/AKT/mTOR signaling pathway NRF2/HO-1/KEAP1 signaling pathway
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Port sustainability:Synergistic pathways and perspectives for air pollution control and carbon mitigation 认领 引用
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作者 Yu Zhang Chenran Li +2 位作者 Tianjiao Dai Zheng Wang Shaojie Song 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期318-330,共13页
As pivotal interfaces of maritime trade and urban-industrial systems,ports are increasingly challenged by their dual roles in enabling economic activity and generating air pollution and carbon emissions.This review pr... As pivotal interfaces of maritime trade and urban-industrial systems,ports are increasingly challenged by their dual roles in enabling economic activity and generating air pollution and carbon emissions.This review provides a structured assessment of emission characteristics,mitigation technologies,and governance strategies aimed at port sustainability.It first delineates the primary emission sources—ships,cargo handling equipment,land transport,and on-site energy systems—focusing on key pollutants such as NOx,SO2,PM2.5,VOCs,and CO2.Synergistic technological pathways are then examined,including ship-based alternatives such as shore power,low-carbon fuels,and carbon capture and storage,along with port-side electrification,operational optimization,and integration of renewables.The review further assesses how regulatory frameworks—encompassing mandatory rules,market-based incentives,and international cooperation—govern the adoption and scaling of these technologies.Drawing on case studies from both developed and developing economies,the review identifies enabling factors including institutional coordination and technological readiness,alongside persistent barriers such as fragmented governance and limited financing.It concludes by outlining four strategic imperatives:accelerating scalable technologies diffusion,enhancing multilevel governance alignment,embedding port transitions within broader urban and industrial systems,and promoting equity through just transition frameworks.By integrating technical and institutional dimensions,the review provides a forward-looking roadmap for low-carbon,clean,and resilient port development. 展开更多
关键词 Green port GHGs mitigation Air pollution control Synergistic pathways Multilevel governance
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The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction 认领 引用
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作者 Kaijie Yan Sihe Gong +4 位作者 Yanni Li Zhonghong Shi Yimin Bao Jing Leng Ke Ning 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期279-288,共10页
Taohong Siwu Decoction(THSWD), a traditional Chinese medicinal formulation, has been demonstrated to significantly modulate key signaling pathways implicated in atherosclerosis(AS). This review examines the complex me... Taohong Siwu Decoction(THSWD), a traditional Chinese medicinal formulation, has been demonstrated to significantly modulate key signaling pathways implicated in atherosclerosis(AS). This review examines the complex mechanisms through which THSWD influences critical pathways, including nuclear factor kappa-B(NF-κB), phosphatidylinositol 3-kinase(PI3K)/serine-threonine kinase(AKT), Toll-like receptor 4(TLR4), mitogen-activated protein kinase(MAPK), and mammalian target of rapamycin(mTOR), that play pivotal roles in AS pathogenesis. By synthesizing experimental evidence and existing literature, the review summarizes how THSWD and its bioactive constituents regulate these signaling cascades to ameliorate AS. Furthermore, it highlights the distinctive therapeutic advantages of traditional Chinese medicine(TCM) compounds in managing chronic diseases driven by multi-target and multifactorial mechanisms. Analyzing disease targets from the perspective of signaling pathways enhances the scientific validation of clinical efficacy for such formulations, thereby offering novel insights for future research. 展开更多
关键词 Atherosclerosis Traditional Chinese medicine Taohong Siwu Decoction Signaling pathways
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Salvia miltiorrhiza-derived carbon dots enhance heat and cold stress tolerance through BrSPL11.1-mediated ascorbic acid biosynthesis and recycling pathways in flowering Chinese cabbage 认领 引用
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作者 Jiajing Zeng Juan Li +5 位作者 Pengli Wang Dalian Lu Min Zhong Yunyan Kang Juxian Guo Xian Yang 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期881-904,共24页
Salvia miltiorrhiza-derived carbon dots(SmCDs)have a potent antioxidant capacity.Squamosa promoter-binding protein-like(SPL)transcription factors respond to both heat and cold stress.However,the molecular mechanisms u... Salvia miltiorrhiza-derived carbon dots(SmCDs)have a potent antioxidant capacity.Squamosa promoter-binding protein-like(SPL)transcription factors respond to both heat and cold stress.However,the molecular mechanisms underlying the regulation of both high temperature(HT)and low temperature(LT)stress by SmCDs through SPL-mediated ascorbate(AsA)biosynthesis and recycling pathways remain unexplored.Therefore,we systematically identified 29 BrSPLs and 16 genes related to AsA biosynthesis and recycling pathways in flowering Chinese cabbage.BrSPL11.1 and three genes(BrGalDH,BrAPX,and BrDHAR1)involved in AsA biosynthesis and recycling pathways were induced by both HT and LT,and their expression patterns were modulated by SmCDs.Functional analyses revealed that the expression of BrGalDH,BrAPX,and BrDHAR1 was suppressed in BrSPL11.1 over expressing(BrSPL11.1-OE)plants,leading to reduced AsA content and reactive oxygen species(ROS)accumulation,as well as enhanced sensitivity to thermal extremes.Conversely,atspl11.1 showed inverse phenotypic and biochemical trends.BrSPL11.1 directly bound to the promoters of BrGalDH,BrAPX,or BrDHAR1 and suppressed their transcription.Silencing BrGalDH,BrAPX,or BrDHAR1 decreased the AsA content and increased ROS accumulation,decreasing HT and LT resistance.SmCDs application effectively elevated the AsA content and attenuated ROS accumulation,alleviating oxidative damage under both stress conditions.Our results established that BrSPL11.1 acts as a dual-temperature stress repressor and that SmCDs enhance HT and LT resistance by regulating BrSPL11.1-mediated AsA biosynthesis and recycling pathways. 展开更多
关键词 Flowering Chinese cabbage Carbon dots SPL transcription factors Temperature stress AsA-GSH pathways
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Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways 认领 引用
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作者 Yi Luo Xiao-Cui Liu +2 位作者 Yu-Jie Li Ming-Hua Qiu Xing-Rong Peng 《Natural Products and Bioprospecting》 CSCD 2026年第1期93-108,共16页
As a dual-purpose medicinal and edible mushroom,Ganoderma species have garnered significant interest in both the food,cosmetics and pharmaceutical industries.To further substantiate its traditional and functional uses... As a dual-purpose medicinal and edible mushroom,Ganoderma species have garnered significant interest in both the food,cosmetics and pharmaceutical industries.To further substantiate its traditional and functional uses,we conducted a systematic phytochemical study of Ganoderma resinaceum fruiting bodies,isolating 43 lanostane-type triterpenoids.Among these,16 were identified as new compounds(1-11,15,31,35,37,and 42).Compound 1 represents the first reported C29 lanostane triterpenoid featuring a 21,24-cyclo five membered carbon ring fraction.The spectroscopic(1D/2D NMR,ESIMS)and X-ray crystallographic analyses confirmed their structures.Among these,compounds 2-4,13,17,35,36,and 42 exhibited potent antioxidant activity by suppressing UV-induced ROS in skin keratinocytes.The most active compound,42,reduced ROS and malondialdehyde(MDA)levels,enhanced antioxidant defenses(superoxide dismutase,SOD;hydroxyproline),and suppressed matrix metalloproteinases(MMPs)through activating Nrf2 pathway and suppressing MAPK signaling.These results position G.resinaceum triterpenoids,particularly compound 42,as multifunctional natural antioxidants with applications in functional foods for oxidative stress management or skin-protective formulations. 展开更多
关键词 Ganoderma resinaceum Lanostane-type triterpenoids Nrf2 MAPK signaling pathway Skin photoaging
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Zhizi-Bopi decoction ameliorates ANIT-induced cholestatic liver injury in mice through IL-17/NF-κB inflammatory pathways 认领 引用
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作者 Wei Cui Tian Chen +7 位作者 Jie-Yao Huang Xiao-Fei Bi Wen-Jin Zhang Yan-Jun Hu Li-Juan Deng Wei Fang Chang-Hui Liu Ya-Ping Xiao 《Traditional Medicine Research》 2026年第1期47-59,共13页
Background:ZhiZi-BoPi Decoction(ZZBPD),a traditional prescription for liver and gallbladder protection,has garnered significant clinical interest due to its hepatoprotective properties.Despite its proven efficacy in m... Background:ZhiZi-BoPi Decoction(ZZBPD),a traditional prescription for liver and gallbladder protection,has garnered significant clinical interest due to its hepatoprotective properties.Despite its proven efficacy in mitigating intrahepatic cholestasis,the precise mechanisms underlying its therapeutic effects remain inadequately understood.This study aims to comprehensively investigate the pharmacological mechanisms underlying the therapeutic effects of ZZBPD in cholestatic liver injury(CLI).Methods:Firstly,we evaluated the hepatoprotective effects of ZZBPD on mice with CLI induced byα-naphthylisothiocyanate(ANIT),by measuring biochemical markers,inflammatory factors,and bile acid levels.Subsequently,we employed network pharmacology and single-cell RNA sequencing(scRNA-seq)to identify key targets and potential signaling pathways for the prevention and treatment of CLI.Finally,we further validated the mechanism of action of ZZBPD on these key targets through molecular docking,western blotting,and immunofluorescence techniques.Results:ZZBPD notably improved serum liver function,reduced hepatic inflammation,and restored bile acid balance.Through network pharmacology and scRNA-seq analysis,48 core targets were identified,including TNF,IL-6,and NFKB1,all of which are linked to the IL-17 and NF-κB signaling pathways,as shown by KEGG enrichment analysis.Molecular docking further confirmed stable interactions between ZZBPD’s key active components and molecules such as IL-6,IL-17,and NF-κB.Additionally,western blotting and immunofluorescence validated the downregulation of IL-17 and NF-κB protein expression in liver tissue.Conclusion:ZZBPD effectively treats CLI by activating pathways related to the bile acid receptor FXR,while also modulating the IL-17/NF-κB signaling pathway.This dual action enhances bile secretion and alleviates liver inflammation.These findings offer important insights into the pharmacological mechanisms of ZZBPD and underscore its potential as a promising therapeutic for CLI. 展开更多
关键词 Zhizi-Bopi decoction cholestatic liver injury network pharmacology single-cell RNA sequencing IL-17/NF-κB signaling pathway
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Integrative catalytic pairs:Four functional pathways toward next-generation multi-intermediate catalysis 认领 引用
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作者 Li Li Yongfu Sun Yi Xie 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第5期494-495,I0012,共2页
Single-atom catalysts(SACs)have long served as ideal platforms for establishing precise structure-activity relationships in heterogeneous catalysis[1,2].Their atomically dispersed active centers maximize metal utiliza... Single-atom catalysts(SACs)have long served as ideal platforms for establishing precise structure-activity relationships in heterogeneous catalysis[1,2].Their atomically dispersed active centers maximize metal utilization and enable fundamental insights into CO/CO2reduction,oxygen and nitrate reduction,methane activation,and selective hydrogenation[3-8]. 展开更多
关键词 single atom catalysts atomically dispersed active centers heterogeneous catalysis their functional pathways structure activity relationships heterogeneous catalysis next generation multi intermediate catalysis selective hydrogenation
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The Ideological System,Development Architecture,and Advancement Pathways of the China-ASEAN Community With a Shared Future 认领 引用
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作者 Xu Liping 《Contemporary World》 2026年第3期13-20,共8页
The year 2026 marks the fifth anniversary of the establishment of the China-ASEAN Comprehensive Strategic Partnership.Since President Xi Jinping proposed jointly building a closer China-ASEAN community with a shared f... The year 2026 marks the fifth anniversary of the establishment of the China-ASEAN Comprehensive Strategic Partnership.Since President Xi Jinping proposed jointly building a closer China-ASEAN community with a shared future in 2013,the initiative has evolved in both substance and depth,growing from concept to practice and from bilateral cooperation to multilateral cooperation. 展开更多
关键词 development architecture comprehensive strategic partnership bilateral cooperation multilateral cooperation ideological system China asean community advancement pathways shared future
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Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury 认领 引用 被引量：6
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作者 Liping Shi Shuyi Liu +2 位作者 Jialing Chen Hong Wang Zhengbo Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期39-56,共18页
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl... Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microglia play an important role in secondary injury and can be activated in response to traumatic brain injury.In this article,we review the origin and classification of microglia as well as the dynamic changes of microglia in traumatic brain injury.We also clarify the microglial polarization pathways and the therapeutic drugs targeting activated microglia.We found that regulating the signaling pathways involved in pro-inflammatory and anti-inflammatory microglia,such as the Toll-like receptor 4uclear factor-kappa B,mitogen-activated protein kinase,Janus kinase/signal transducer and activator of transcription,phosphoinositide 3-kinase/protein kinase B,Notch,and high mobility group box 1 pathways,can alleviate the inflammatory response triggered by microglia in traumatic brain injury,thereby exerting neuroprotective effects.We also reviewed the strategies developed on the basis of these pathways,such as drug and cell replacement therapies.Drugs that modulate inflammatory factors,such as rosuvastatin,have been shown to promote the polarization of antiinflammatory microglia and reduce the inflammatory response caused by traumatic brain injury.Mesenchymal stem cells possess anti-inflammatory properties,and clinical studies have confirmed their significant efficacy and safety in patients with traumatic brain injury.Additionally,advancements in mesenchymal stem cell-delivery methods—such as combinations of novel biomaterials,genetic engineering,and mesenchymal stem cell exosome therapy—have greatly enhanced the efficiency and therapeutic effects of mesenchymal stem cells in animal models.However,numerous challenges in the application of drug and mesenchymal stem cell treatment strategies remain to be addressed.In the future,new technologies,such as single-cell RNA sequencing and transcriptome analysis,can facilitate further experimental studies.Moreover,research involving non-human primates can help translate these treatment strategies to clinical practice. 展开更多
关键词 animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell microglia neuroinflammation non-human primate signaling pathway traumatic brain injury
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Microwave assisted metal-free catalysts preparation from waste plastics for efficient pollutants degradation: Interesting relationship between plastic types and nonradical/radical pathways 认领 引用 被引量：1
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作者 Denghong Zhao Mingwei Yang +9 位作者 Yichuan Zhang Long Qin Hang Liu Hongji Chen Maoguo Tan Zhongyi Yin Bin Sun Yu Shen Haijiao Xie Heyan Jiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期371-378,共8页
To implement the principle of utilizing waste to address waste issues,porous carbon catalytic materials,prepared through a straightforward process involving NaOH-assisted microwave pyrolysis of ubiquitous waste plasti... To implement the principle of utilizing waste to address waste issues,porous carbon catalytic materials,prepared through a straightforward process involving NaOH-assisted microwave pyrolysis of ubiquitous waste plastics,were employed to degrade pollutants via peroxymonosulfate(PMS) activation.Polyethylene terephthalate(PET) derived P1S2 exhibited characteristics of defects enrichment and C=O formation,while H1S2,prepared by carbonization of high-density polyethylene(HDPE),possessed a large number of C-OH and defects.Metal-free catalysts P1S2 and H_i S2 exhibited excellent tetracycline(TC) degradation performance,with the rate constants up to 0.303 min-1 and 0.235 min-1.Interestingly,mechanism studies demonstrated that the types of waste plastic precursor had a significant impact on the pathways involved in TC degradation.Specifically,carbon defects in p1S2 dominated the electron transfer nonradial degradation pathway of TC;However,C-OH in H1S2 served as the reactive site for main active species SO4·-/·OH generation,initiating a free radical pathway.In addition,by combining Fukui function calculation and LC-MS test during the TC degradation process,the vulnerable sites attacked by active species were identified;different degradation routes of TC in nonradial and radial pathways were proposed and discussed.Furthermore,the toxicity of all intermediates was analyzed using the toxicity assessment software.This study offers fresh insights into the critical role of carbocatalysts derived from various waste plastics in both nonradical and radical activation processes of PMS. 展开更多
关键词 Waste plastic Porous carbon material Microwave pyrolysis Peroxymonosulfate Nonradicaladical pathways
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The influence of a changing Arctic on midlatitude climate and extremes:a review of pathways and uncertainties 认领 引用 被引量：1
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作者 GAO Yizhou YANG Zibo +6 位作者 ZHANG Ruonan LIU Jiping LEI Ruibo YOU Qinglong YE Kunhui HUA Wenjian ZOU Chuntao 《Advances in Polar Science》 CSCD 2026年第2期123-141,共19页
In the context of global warming,the ongoing reduction in Arctic sea ice and associated influences have become a focal point.Many studies have linked Arctic changes to extreme weather and climate events in the Norther... In the context of global warming,the ongoing reduction in Arctic sea ice and associated influences have become a focal point.Many studies have linked Arctic changes to extreme weather and climate events in the Northern Hemisphere midlatitudes,including cold spells,heatwaves,droughts,storms,and wildfires.However,the causality and physical pathways of the Arctic–midlatitude linkage remain controversial and highly uncertain,hindering the attribution of extremes to Arctic climate change.This study builds on extensive previous research and reviews recent progress in understanding the influence of Arctic amplification and sea ice loss on midlatitude climate variability,as well as the associated uncertainties.The impacts of Arctic changes on the midlatitude weather and climate are substantially mediated by the jet streams,Rossby waves,transient eddy-mean flow interactions,and the stratospheric polar vortex.Despite the enhanced comprehension of mechanisms and pathways,the aforementioned Arctic-midlatitude linkage remains debated.The ongoing prospection is attributed to the noise arising from intrinsic atmospheric variability,Arctic nonlinearities,lower latitude factors,and climate background state.The present study has sought to elucidate the intricacies of the Arctic-midlatitude linkage,with a particular focus on the ramifications for mean and extreme weather and climate conditions in Eurasia and North America.This study also specifically introduces discussions about the sources of uncertainty and possible underlying causes that need to be addressed. 展开更多
关键词 Arctic change Arctic-midlatitude linkage mechanisms pathways uncertainties
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Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways 认领 引用
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作者 Haiyang Sun Shuhuai Meng +10 位作者 He Cai Zhengyi Xu Kuo Gai Dan Meng Yixin Shi Feng Luo Xibo Pei Jian Wang Anjali P.Kusumbe Qianbing Wan Junyu Chen 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第2期241-257,共17页
Excessive lighting is integral to dentists’daily routines but can impair their vision,affecting personal and professional performance.Most studies focus on acute photodamage,neglecting chronic photo-injury from denta... Excessive lighting is integral to dentists’daily routines but can impair their vision,affecting personal and professional performance.Most studies focus on acute photodamage,neglecting chronic photo-injury from dental lighting and its impact on the blood-retinal barrier homeostasis.An epidemiological survey involving 14523 individuals showed dentists had 3.6 times higher odds of visionrelated issues compared to other occupations(OR=3.639,95%CI:3.064–4.323).Subsequently,chronic photodamage models in rats were created to accurately simulate dental working conditions.Using systematic imaging and gene analysis,including OCT,tissue clearing technology and RNA-sequencing,dental lighting was found to disrupted both inner and outer blood-retinal barriers,reduced retinal blood vessels,and promoted perivascular macrophage recruitment.Among them,the number of capillary branches decreased sharply.Moreover,the activation of inflammatory-related pathways such as NF-κB signaling resulted in the damage of vision-related functional structures in the retina.Notably,among three dental light sources,low-intensity halogen caused minimal retinal damage,whereas blue and white LEDs significantly disrupted blood-retinal barrier homeostasis.This study explored the potential mechanism of dental lighting environment inducing the disruption of blood-retinal barrier homeostasis,and provided essential guidance for dental professionals in selecting light sources,which is conducive to reducing the risk of occupational ocular diseases among dentists. 展开更多
关键词 vascular pathways inflammatory pathways photodamage models chronic dental lighting epidemiological survey dental lighting blood retinal barrier acute photodamageneglecting
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Preferential Lewis-basic ion pathways for accelerated Zn2+ diffusion and uniform deposition at zinc metal anodes 认领 引用
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作者 Linxia Yu Quan Zong +8 位作者 Xin Li Guoying Wei Qilong Zhang Qiaoling Kang Jingji Zhang Gongxun Bai Shuang Zhou Anqiang Pan Chengbin Jin 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期645-656,I0016,共12页
With advantages of high safety,low cost,and environmental friendliness,aqueous zinc metal batteries(ZMBs)are widely recognized as potential next-generation systems for grid-scale energy storage.However,their widesprea... With advantages of high safety,low cost,and environmental friendliness,aqueous zinc metal batteries(ZMBs)are widely recognized as potential next-generation systems for grid-scale energy storage.However,their widespread application suffers from unstable Zn/electrolyte interfaces induced by uncontrolled Zn2+desolvation,migration,and deposition.Herein,we propose a molecularly engineered interfacial layer,created through a hydrolysis-condensation molecular assembly,that couples hydrophobic exclusion,preferential Zn2+transport pathways,and Lewis-basic coordination centers within a single framework.The strong electronegativity and hydrophobic properties of the macromolecular layer effectively repel anions and exclude free water molecules from the Zn surface,thereby suppressing hydrogen evolution and byproduct accumulation.Meanwhile,the preferential ion channels enriched with Lewisbase sites provide favorable Zn2+coordination environments,accelerate desolvation kinetics,and promote preferential ion migration,ultimately lowering nucleation barriers and homogenizing Zn2+flux.Benefiting from this regulation of interfacial chemistry and transport kinetics,the modified Zn anode achieves dendrite-free and highly reversible Zn plating/stripping,delivering a long cycling lifespan(3600 h at 1 m A cm-2and 1 mAh cm-2),high Coulombic efficiency(99.7%after 1200 cycles),and excellent full-cell capacity retention(95%after 2000 cycles). 展开更多
关键词 Hydrophobicity Preferential ion pathways Lewis-base sites Dendrite-free
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Scytosiphon lomentaria fucoidan alleviates alcohol-induced liver injury in mice via the modulation of gut microbiota and bile acid-FXR/AMPK and NF-κB pathways 认领 引用
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作者 Yiyun Sun Qiuyue Men +3 位作者 Xiaomeng Ren Xiaoming Guo Shuang Song Chunqing Ai 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期650-661,共12页
Alcohol intake is associated with increased mortality worldwide,particularly liver diseases,making it imperative to explore innovative strategies for managing alcohol-related liver disease.In this study,t he efficacy ... Alcohol intake is associated with increased mortality worldwide,particularly liver diseases,making it imperative to explore innovative strategies for managing alcohol-related liver disease.In this study,t he efficacy of Scytosiphon lomentaria fucoidan(SLF)in alleviating alcohol-induced liver injury was evaluated in a mouse model.It showed that SLF increased body weight and colon length,while reducing liver index,serum lipid,alanine aminotransferase,and aspartate aminotransferase in alcohol-treated mice.SLF inhibited inflammatory response in the liver by reducing inflammatory infiltration and the levels of pro-inflammatory cytokines.It can be associated with the alleviation of oxidative stress and the inhibition of the nuclear factor-κB pathway.SLF modulated alcohol-induced dysbiosis of gut microbiota,including a reduction in Bacteroidetes and Proteobacteria,and improved metabolites profile,primarily affecting short chain fatty acids and amino acids metabolism.In addition,SLF reduced the level of total bile acids,regulated the profile of bile acids,and increased the levels of farnesoid X receptor(FXR)and AMP-activated protein kinase(AMPK),suggesting that SLF can alleviate alcohol-induced liver injury by regulating bile acid-FXR/AMPK pathway.This study suggests that SLF holds the potential to alleviate the adverse effect of alcohol on the liver via the gut-liver axis. 展开更多
关键词 Scytosiphon lomentaria fucoidan Alcoholic liver injury Gut microbiota Bile acid metabolism FXR/AMPK pathway NF-κB pathway Gut-liver axis
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Greenhouse gas emissions from construction machinery in China:Historical trends and prospective reduction pathways 认领 引用
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作者 Linzhen Qu Yangyang Cui +4 位作者 Guanghan Huang Huawei Yi Kaiyun Liu Yifeng Xue Lei Nie 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期852-861,共10页
China's rapid urbanization has driven extensive construction activities,leading to the widespread deployment of fuel-powered construction machinery and substantial greenhouse gas(GHG)emissions.We combined surveys ... China's rapid urbanization has driven extensive construction activities,leading to the widespread deployment of fuel-powered construction machinery and substantial greenhouse gas(GHG)emissions.We combined surveys on machinery units,operational hours,and load factors to quantify GHG emissions(CO2,CH4,and N2O)from construction machinery in China from 2013 to 2022.Emissions projections were modeled using the low emissions analysis platform(LEAP)under baseline,market-driven,policy-guided,and regulatory-driven scenarios,with parameters including machinery stock,electrification rate,and fuel consumption per hour.The results indicate that from 2013 to 2022,the number of machinery units increased significantly,driving parallel growth in CO2 and N2O emissions,whereas CH4 emissions demonstrated consistent annual decreases because of emission intensity.CO2 equivalent(CO2 eq)emissions increased by 17% from 2013 to 2021 and then decreased by 2.6% to 7.3×107t CO2 eq in 2022,with CO2 accounting for 98%-99% of total GHG emissions and N2O and CH4 accounting for1.2% and 0.1%,respectively.The primary emission sources were China StageⅢmachinery(69%),excavators(64%),and high-power equipment(>130 kW,contributing 30%-90%).Spatially,East China accounted for 47% of national emissions in 2022,followed by Central China(18%),which is related mainly to the advanced economic development and infrastructure construction demands.The scenario analysis showed that reducing machinery numbers,enhancing electrification,and improving fuel efficiency could yield substantial mitigation benefits,with the regulatory-driven scenario achieving up to 97% GHG reduction potential. 展开更多
关键词 Construction machinery Greenhouse gas Emission reduction pathway
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