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Inhibition research of double protection on flame propagations of hydrogen doped methane explosions 认领 引用
1
作者 Xingyan Cao Min Zhang +3 位作者 Yue Wang Xiang Zhou Zhirong Wang Shaochen Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第4期170-182,共13页
This experiment aimed at the synergy effect of ripple flame arrester and water mist on hydrogen doped methane explosions.By comparing the dynamic flame resistance process and changes in explosion parameters,the mechan... This experiment aimed at the synergy effect of ripple flame arrester and water mist on hydrogen doped methane explosions.By comparing the dynamic flame resistance process and changes in explosion parameters,the mechanism of synergy inhibition was clarified.Result explains that both synergies enhanced the protection efficiency of gas explosions.Spray conditions could greatly affect the propagation velocity of flames entering narrow channels,thus affecting its stagnation time inside the ripple hole and quenching probability.The synergy was attributed to the combined action of mist parameters on weakening and enhancing effects.As the nozzle type enlarged,the increase in mist parameter promoted a decrease in pressures at both ends,even the complete inhibition was achieved.Inhibition effect was gradually enhanced as the spray time prolonged,and explosion-resistance parameters were also greatly decreased.But the inhibition result showed a variation process of“failure-success-failure”as the spray pressure enlarged,and explosion-resistance parameters also displayed a change of first reducing and then rising.Under the synergy effect,the inhibition could be achieved as the generation rate of free radicals was lower than the destruction rate and flame temperature at the ripple hole outlet was lower than the critical flame resistance temperature. 展开更多
关键词 Hydrogen doped methane Explosions Synergy inhibition Microscale Heat transfer
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Pan-KRAS inhibition:unlocking broad-spectrum targeted therapy for KRAS-mutant cancers 认领 引用
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作者 Juanjuan Feng Xuanzheng Xiao +2 位作者 Zhengke Lian Ao Zhang Xiufeng Pang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第2期162-168,共7页
KRAS is a critical proto-oncogene and molecular switch that is frequently mutated in human cancers.Oncogenic mutations,primarily at codons 12,13,and 61,lock KRAS into a GTPbound active state,thus resulting in constitu... KRAS is a critical proto-oncogene and molecular switch that is frequently mutated in human cancers.Oncogenic mutations,primarily at codons 12,13,and 61,lock KRAS into a GTPbound active state,thus resulting in constitutive signaling through downstream effectors such as RAF and phosphoinositide 3-kinase(PI3K)1.These alterations are highly prevalent in pancreatic cancer,colorectal cancer(CRC),and non-small cell lung cancer(NSCLC),and they drive tumor initiation,progression,and therapy resistance. 展开更多
关键词 constitutive signaling downstream effectors broad spectrum targeted therapy proto oncogene pan kras inhibition kras mutant cancers molecular switch therapy resistance
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Metagenomic-based observations regarding the inhibition effect of viruses on resistance genes in aquaculture system 认领 引用
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作者 Jun Wu Jian Lu +1 位作者 Jianhua Wang Brian J.Boman 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第6期79-92,共14页
Viruses widely existing in the nature play important role in the various ecosystem.However,rare information is available regarding the quantitative effect of viruses on resistance genes in recirculating aquaculture sy... Viruses widely existing in the nature play important role in the various ecosystem.However,rare information is available regarding the quantitative effect of viruses on resistance genes in recirculating aquaculture system(RAS)which is an artificially-regulated advanced aquaculture mode.This study investigated the potential effect of viral community on both antibiotic resistance genes(ARGs)and metal resistance genes(MRGs)in a typical RAS based on metagenomic analysis.The results showed that viruses averagely accounted for 24.6%/0.1%of microbial community in wateresidues of RAS operational units.Caudovirales were the predominant annotated order covering 32.5%of viral orders while Ligamenvirales and Picornavirales were not detected in residue samples.The total relative abundances of ARGs in the wateresidue samples of RAS were in the range of(0.044-0.144)/(0.029-0.162)copies/16S rRNA copy while those ofMRGs in thewateresidue samples ofRAS were in the range of(1058.6-2020.0)/(2263.2-3744.7)copies/16S rRNA copy.Caudovirales and Herpesvirales were frequently negatively related with ARGs in residue samples while Herpesvirales were often negatively related with MRGs in water.Viruses showed inhibition effect on ARGs and MRGs in RAS according to both the network analysis and pathway analysis.This study provided new insight on the relationship between viruses and resistance genes,regarding inhibition effect of viruses on resistance genes. 展开更多
关键词 Virus Resistance genes Recirculating aquaculture system Metagenetic analysis Inhibition effect
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Fluorescent probes reveal the differential impact of ferroptosis inhibition on drug-induced liver and kidney injury 认领 引用
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作者 Wei Zhang Lei Yang +4 位作者 Zhihang Jin Shusheng Zhang Fawei Zhu Zhanxian Li Mingming Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期603-608,共6页
Ferroptosis has emerged as a significant pathway in various pathological conditions.Studying the effects of inhibiting ferroptosis on liver injury is instrumental in gaining a deeper understanding of the mechanisms.Th... Ferroptosis has emerged as a significant pathway in various pathological conditions.Studying the effects of inhibiting ferroptosis on liver injury is instrumental in gaining a deeper understanding of the mechanisms.This study the design and synthesis of a multi-channel near-infrared emitting fluorescent probe TXVQ.When the probe TXVQ responds to HSO3-,the fluorescence intensity at 500 nm of TXVQ increases with the addition of HSO3-.As the concentration of H2O2 increases,the fluorescence intensity of TXVQ at 600 nm is enhanced.Concurrently,as viscosity rises,the fluorescence intensity of the probe TXVQ at 725 nm will gradually increase.The probe TXVQ,with its ability to monitor HSO3-,H2O2 and viscosity through three distinct fluorescent channels,is advantageous for its application in the biological field.Subsequently,cellular experiments have demonstrated that the probe TXVQ can monitor changes in intracellular HSO3-,H2O2 and viscosity.At the cellular level,it is found that inhibiting ferroptosis had no alleviating effect on drug-induced liver injury(DILI),but it had a certain alleviating effect on acute kidney injury(AKI).In a murine model,the effects of ferroptosis inhibition on DILI and AKI indicate that inhibiting ferroptosis reduced kidney injury but not liver injury,highlighting its potential in kidney therapeutics.TXVQ can detect various levels of HSO3-,H2O2 and viscosity through three different fluorescent channels,making it a powerful tool for diagnosing and treating kidney diseases,as well as deepening the understanding of the role of ferroptosis in liver and kidney pathologies. 展开更多
关键词 Ferroptosis inhibition Drug-induced liver injury Kidney injury HSO3- H2O2 Viscosity
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Plasmonic metallic Bi-modified defective Bi4Ti3O12nanosheets with upward migrating electrons for efficient photocatalytic NO removal and NO2inhibition 认领 引用
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作者 Wenjie He Lin Jing +9 位作者 Wendong Zhang Xing’an Dong Yan Zou Xin Liu Xin Lv Peng Chen Jiazhen Liao Xiao Zhang Rong Xiao Yuechang Wei 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期704-707,共4页
The limited redox capability of photocatalysts often leads to harmful NO2 byproduct formation during photocatalytic NO oxidation.Herein,Bi4Ti3O12 nanosheets modified with plasmonic metallic bismuth and abu... The limited redox capability of photocatalysts often leads to harmful NO2 byproduct formation during photocatalytic NO oxidation.Herein,Bi4Ti3O12 nanosheets modified with plasmonic metallic bismuth and abundant oxygen vacancies were synthesized via an in-situ reduction method.The optimized catalyst(BTOR2,with a molar ratio of 40%NaBH4 to Bi4Ti3O12)achieved a maximum NO removal efficiency of 62.3%,significantly higher than pristine Bi4Ti3O12(40.5%) while minimizing NO2 production.The results reveal that the synergistic effects of Bi’s plasmonic resonance and oxygen vacancies enhanced visible light absorption and charge separation.The density functional theory(DFT)analysis showed electrons can transfer from Bi4Ti3O12to Bi,promoting O2activation to·O2-radicals.In-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)confirmed that light-induced H2O adsorption was strengthened,improving·OH radical generation.These radicals promoted the selective conversion of activated NO- to NO3-,rather than NO2.This work provides valuable insights for advancing research into efficient photocatalysts for air pollution control. 展开更多
关键词 Plasmonic metallic bismuth Oxygen vacancy Bi4Ti3O12 NO2inhibition Photocatalysis mechanism
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Inhibition performance and mechanisms of methane hydrate inhibitors in oil and gas pipelines 认领 引用
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作者 Jie Wang Yong Cheng +3 位作者 Yuan Li Pan Ma Hualei Xu Houshun Jiang 《Natural Gas Industry B》 2026年第2期239-255,共17页
During winter natural gas transportation,hydrate formation under low-temperature and high-pressure conditions frequently results in pipeline blockage and severe low assurance challenges.Although conventional thermodyn... During winter natural gas transportation,hydrate formation under low-temperature and high-pressure conditions frequently results in pipeline blockage and severe low assurance challenges.Although conventional thermodynamic hydrate inhibitors(THIs)are effective in shifting hydrate phase equilibrium,the application is constrained by high volumetric injection requirements and the associated operational costs,thereby driving research interest toward low-dosage hydrate inhibitors(LDHIs).This study integrates high-pressure pipeline flow simulations with molecular dynamics simulations to systematically evaluate the inhibition performance and elucidate the molecular-scale mechanisms of representative inhibitor classes in methane hydrates.Pipeline simulation results indicate that,at low additive concentrations:(1)the inhibition effectiveness of cations follows the order Al3+>Fe2+>Ca2+>Na+,suggesting a strong dependence on ionic charge density;(2)at identical mass fraction,methanol exhibits greater thermodynamic inhibition performance than ethylene glycol.Notably,5.0 wt% ethylene glycol accelerates hydrate formation kinetics,exhibiting an anomalous promotion effect.For kinetic inhibitors and their blends,the following observations were obtained:(3)PVP K30 exhibited optimal inhibition performance at 1.0 wt%,significantly extending the hydrate induction time;moreover,the combination of 1.0 wt%PVP K30 with 5.0 wt%methanol completely suppressed hydrate formation under the tested conditions while substantially reducing the required alcohol dosage;(4)molecular-scale analysis indicates that methanol and ethylene glycol primarily act by shifting the hydrate phase equilibrium and perturbing the hydrogen-bond network of water.In contrast,PVP K30 inhibits hydrate formation by disrupting hydrogen-bond structures and decreasing methane-water association through steric hindrance and interfacial adsorption.The blended system exhibits a clear synergistic effect between thermodynamic and kinetic inhibition,combining a phase equilibrium shift with delayed hydrate formation kinetics.This THI-focused investigation systematically clarifies the inhibition of mechanisms of representative additives and provides a scientific basis for selecting costeffective LDHIs strategies for hydrate control in oil and gas pipelines,with direct relevance to mitigating hydrate blockage in field operations. 展开更多
关键词 Methane hydrates Pipeline transport Hydrate inhibitors Molecular dynamics simulation Synergistic inhibition effect
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Self-assembly of disassemblable supramolecular organic frameworks for doxorubicin delivery,photofrin posttreatment phototoxicity inhibition and heparin neutralization 认领 引用
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作者 Ya-Jie Zhu Zhi-Min Lv +5 位作者 Hao-Feng Zhu Qi-Yan Qi Shang-Bo Yu Jia Tian Wei Zhou Zhan-Ting Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期320-326,共7页
Two supramolecular organic frameworks(SOFs)have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water.Dynamic light scattering and 1H NMR experiments re... Two supramolecular organic frameworks(SOFs)have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water.Dynamic light scattering and 1H NMR experiments reveal that both SOFs can undergo reversible assembly and disassembly at room temperature.One of the SOFs displays unprecedently high maximum tolerated dose of 120 mg/kg with mice,which improves by 40%compared with the highest value of the reported SOFs.In vitro and in vivo tests show that the SOF can adsorb doxorubicin and overcome the resistance of multidrugresistant MDR A549/ADR tumor cells to realize intracellular delivery,leading to enhanced antitumor efficacy.Moreover,it can also completely inhibit the posttreatment phototoxicity of photofrin and fully neutralize the anticoagulation of both unfractionated heparin and low molecular weight heparins through efficient inclusion and elimination or sequestration mechanism.As the first examples that undergo roomtemperature reversible assembly and disassembly,the new SOFs in principle allow for quantitative analysis of the molecular components in the body that is prerequisite for preclinical evaluation in the future. 展开更多
关键词 Supramolecular organic framework Self-assembly and disassembly Biosafety Drug delivery Porphyrin phototoxicity inhibition Heparin antagonism
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Secretase inhibition in Alzheimer's disease therapeutics reveals functional roles of amyloid-beta42 认领 引用
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作者 Timothy Daly Bruno P.Imbimbo 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2003-2004,共2页
In the words of the late Sir Colin Blakemore,neurologists have historically sought to infer brain functions in a manner akin to to king a hammer to a computeranalyzing localized anatomical lesions caused by trauma,tum... In the words of the late Sir Colin Blakemore,neurologists have historically sought to infer brain functions in a manner akin to to king a hammer to a computeranalyzing localized anatomical lesions caused by trauma,tumors,or strokes,noting deficits,and inferring what functions certain brain regions may be responsible for.This approach exemplifies a deletion heuristic,where the absence of a specific function reveals insights about the underlying structures or mechanisms responsible for it.By observing what is lost when a particular brain region is damaged,throughout the history of the field,neurologists have pieced together the intricate relationship between anatomy and function. 展开更多
关键词 infer brain functions secretase inhibition Alzheimers disease therapeutics king hammer deletion heuristic amyloid beta deletion heuristicwhere observing what l
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Surface-engineered magnetic nanoparticles with carboxymethyl inulin coating for interface-controlled mineral scale inhibition 认领 引用
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作者 Abdelrahman T.Abdelaal Farah M.El-Makaty +1 位作者 Malcolm A.Kelland Mohamed F.Mady 《Particuology》 SCIE EI CAS CSCD 2026年第8期15-24,共10页
In this study,magnetite nanoparticles(Fe3O4)were surface-engineered with a biobased carboxymethyl inulin(CMI)coating to develop a recyclable inhibitor for controlling mineral scale formation through interfacial in-ter... In this study,magnetite nanoparticles(Fe3O4)were surface-engineered with a biobased carboxymethyl inulin(CMI)coating to develop a recyclable inhibitor for controlling mineral scale formation through interfacial in-teractions.The Fe3O4@CMI nanocomposite was synthesized via co-precipitation,achieving a uniform~59 wt%polymer layer without altering the cubic spinel structure of magnetite.Comprehensive surface and interface characterization by XRD,FTIR,TGA,VSM,and SEM confirmed the preservation of superparamagnetic properties and effective polymer anchoring via carboxylate-iron interactions.The coated nanoparticles exhibited strong affinity for scaling ions,disrupting crystal nucleation and growth at the solid-liquid interface,as evidenced by morphological transformations of gypsum,calcite,and barite deposits.Under both static and high-pressure-high-temperature dynamic conditions,Fe3O4@CMI achieved complete gypsum inhibition at concentrations as low as 1-5 ppm and maintained full efficiency over multiple magnetic recovery cycles.Enhanced calcium compatibility in saline brines further underscores the stability of the modified surface,preventing secondary precipitation and enabling reliable reuse.These results highlight the critical role of interface engineering in tailoring nano-particle-scale crystal interactions for sustainable and low-discharge chemicals for oilfield scale management. 展开更多
关键词 Magnetic nanoparticles Carboxymethyl inulin Scale inhibition Recycling Oilfield management
Reshaping“Cerebellar Inhibition”:Mechanistic Insights and Precision Medicine Perspectives for rTMS in Machado-Joseph Disease 认领 引用
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作者 HAN Ya-Zhen ZHOU Jie +2 位作者 CHEN Yu-Chao GAO Zhong-Ming CHE Xian-Wei 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2026年第2期505-510,共6页
Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remai... Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remain elusive.Repetitive transcranial magnetic stimulation(rTMS)has emerged as a promising non-invasive intervention;however,its clinical application has been hindered by inconsistent protocols and a lack of mechanistic understanding.A recent landmark study published in Brain Stimulation by Chen et al.addressed these challenges by combining a high-dose intermittent theta-burst stimulation(iTBS)protocol with concurrent transcranial magnetic stimulation-electroencephalography(TMS-EEG).This commentary provides an in-depth analysis of their findings,highlighting the restoration of cerebello-cortical inhibition(CBI)as a key therapeutic mechanism.Furthermore,we discuss the broader implications of this work,proposing that future translational research should integrate accelerated iTBS(aiTBS)paradigms,cortical response measurements(CRM),and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia. 展开更多
关键词 Machado-Joseph disease(spinocerebellar ataxia type 3,SCA3) transcranial magnetic stimulationelectroencephalography(TMS-EEG) cerebello-cortical inhibition neuromodulation precision medicine
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Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition 认领 引用
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作者 Raphaela Goldbach-Mansky 《四川生理科学杂志》 2026年第2期277-277,共1页
Background:Neonatal-onset multisystem inflammatory disease is characterized by fever,urticarial rash,aseptic meningitis,deforming arthropathy,hearing loss,and mental retardation.Many patients have mutations in the col... Background:Neonatal-onset multisystem inflammatory disease is characterized by fever,urticarial rash,aseptic meningitis,deforming arthropathy,hearing loss,and mental retardation.Many patients have mutations in the cold-induced autoinflammatory syndrome 1(CIAS1)gene,encoding cryopyrin,a protein that regulates inflammation. 展开更多
关键词 interleukin beta inhibition cryopyrin inflammation cold induced autoinflammatory syndrome neonatal onset multisystem inflammatory disease rashaseptic meningitisdeforming arthropathyhearing
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Oxytocin ameliorates cognitive impairments by attenuating excitation/inhibition imbalance of neurotransmitters acting on parvalbumin interneurons in a mouse model of sepsisassociated encephalopathy 认领 引用 被引量：1
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作者 Renqi Li Qiuting Zeng +5 位作者 Muhuo Ji Yue Zhang Mingjie Mao Shanwu Feng Manlin Duan Zhiqiang Zhou 《Journal of Biomedical Research》 CAS CSCD 2025年第2期132-145,共14页
Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parval... Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parvalbumin(PV) interneurons are pivotal contributors to cognitive processes and have been implicated in various central nervous system dysfunctions, including SAE. Oxytocin, known for its ability to augment the firing rate of gamma-aminobutyric acid(GABA)-ergic interneurons and directly stimulate inhibitory interneurons to enhance the tonic inhibition of pyramidal neurons, has prompted an investigation into its potential therapeutic effects on cognitive dysfunction in SAE. In the current study, we administered intranasal oxytocin to SAE mice induced by lipopolysaccharide. Behavioral assessments, including open field, Y-maze, and fear conditioning, were used to evaluate cognitive performance. Golgi staining revealed hippocampal synaptic deterioration, local field potential recordings showed weakened gamma oscillations, and immunofluorescence staining demonstrated decreased PV expression in the cornu ammonis 1(CA1) region of the hippocampus following lipopolysaccharide treatment, all of which were alleviated by oxytocin administration. Furthermore, immunofluorescence staining of PV co-localization with vesicular glutamate transporter 1 or vesicular GABA transporter indicated a balanced excitation/inhibition effect of neurotransmitters on PV interneurons after oxytocin administration in the SAE mice, leading to an improved cognitive function. In conclusion, oxytocin treatment improved cognitive function by increasing the number of PV+ neurons in the hippocampal CA1 region, restoring the balance of excitatory/inhibitory synaptic transmission on PV interneurons, and enhancing hippocampal CA1 local field potential gamma oscillations. These findings suggest a potential mechanism underlying the beneficial effects of oxytocin in SAE. 展开更多
关键词 excitation/inhibition balance oxytocin cognitive sepsis-associated encephalopathy
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Enhanced glutamine inhibition and photothermal therapy for breast cancer using Janus mesoporous organosilica-coated platinum nanomotors 认领 引用
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作者 Xiao-Feng Chen Zhi-Hui Chen +8 位作者 Nan Zhong Yang Liu Xuan Sha Yang Li Zi-Qing Xu Jie Zhang Shou-Ju Wang Cui-Ying Li Yu-Xia Tang 《Rare Metals》 SCIE EI CAS CSCD 2025年第10期7576-7586,共11页
In the treatment of breast cancer,the combination of glutamine metabolism inhibition and photothermal therapy(PTT)is gaining increasing attention.This study developed a Janus nanomotor to enhance permeability in tumor... In the treatment of breast cancer,the combination of glutamine metabolism inhibition and photothermal therapy(PTT)is gaining increasing attention.This study developed a Janus nanomotor to enhance permeability in tumor tissues for nanomedicine applications by using mesoporous organic silica(PMO)anisotropic ally grown on the surface of the platinum(Pt)nanoparticles(PMO@Pt).The prepared PMO@Pt had unique Janus structure with an average size of approximately 236 nm.The loading capacity of V9302 was evaluated to be 44.37%when the mass ratio of V9302 to PMO@Pt was maintained at 2.0 and in vitro release studies demonstrated that acidic environments significantly enhanced the drug release.Then this nanomotor was loaded with perfluorohexane(PFH),a phase-change material,and the glutamine inhibitor V9302(denoted as Janus PMO@Pt@PFH@V9302,JPV).Janus PMO@Pt@PFH(JPP)nanomotors demonstrated enhanced fluorescence intensity and distribution within 3D tumor spheroids compared to Janus PMO@Pt nanomotors,attributed to the photothermal-induced phase change of PFH.The nanomotors exhibited high biocompatibility,with cell viability exceeding 98%at high concentrations.However,the incorporation of V9302 into the nanomotors(JPV)significantly reduced 4T1 cell viability under laser irradiation,indicating a cytotoxic effect resulting from the synergy between photothermal therapy and glutamine metabolism inhibition.In vivo,JPV nanomotors effectively inhibited tumor growth and induced apoptosis without causing significant systemic toxicity,showcasing their potential as a therapeutic agent for breast cancer.This integrated nanomotor offers a promising approach for enhanced ultrasound imaging and photothermal therapy in cancer treatment. 展开更多
关键词 Janus nanomotors Photothermal therapy Glutamine inhibition Drug delivery Ultrasound imaging
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Inhibition of KLK8 promotes pulmonary endothelial repair by restoring the VE-cadherin/Akt/FOXM1 pathway 认领 引用
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作者 Ying Zhao Hui Ji +10 位作者 Feng Han Qing-Feng Xu Hui Zhang Di Liu Juan Wei Dan-Hong Xu Lai Jiang Jian-Kui Du Ping-Bo Xu Yu-Jian Liu Xiao-Yan Zhu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第4期870-872,共3页
Repairing the endothelial barrier is essential for maintaining pulmonary fuid balance and regulating leukocyte infiltration during sepsis[1].Tissue kallikrein-related peptidases(KLKs)are secreted serine proteases invo... Repairing the endothelial barrier is essential for maintaining pulmonary fuid balance and regulating leukocyte infiltration during sepsis[1].Tissue kallikrein-related peptidases(KLKs)are secreted serine proteases involved in angiogenesis[2].However,their involvement in regulating endothelial regeneration remains largely unknown. 展开更多
关键词 repairing endothelial barrier regulating leukocyte infiltration pulmonary endothelial repair inhibition klk ve cadherin maintaining pulmonary fuid balance serine proteases
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Hole inhibition mechanisms of Mg/steel lap joint by pinless friction stir spot welding 认领 引用
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作者 Tao-tao Li Hong-de Ding +5 位作者 Rui-feng Li Kai Qi Zhen-guang Liu Xiao-qiang Zhang Yue Zhao Lei Qiao 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第4期1085-1101,共17页
Pinless friction stir spot welding(P-FSSW)was performed to manufacture Mg/steel lap joints.Orthogonal tests for P-FSSW of Mg/steel were investigated,and the main factors affecting the properties of Mg/steel lap joints... Pinless friction stir spot welding(P-FSSW)was performed to manufacture Mg/steel lap joints.Orthogonal tests for P-FSSW of Mg/steel were investigated,and the main factors affecting the properties of Mg/steel lap joints were derived.The shear force of the Mg/steel lap joints gradually increased and then decreased as the welding time increased.Maximum shear force was 5.3 kN.Fe-Al intermetallic compound(IMC)was formed at the Mg/steel interface near the steel side,and Mg-Al IMCs were formed at the Mg/steel interface near the Mg alloy side.Mg/steel lap joint was transformed from an initial solid-state welding to fusion-brazing welding as the welding time increased.No hole defects were formed in Mg/steel solid-state welding joints,whereas hole defects appeared in Mg/steel fusion-brazing welding joints.The temperature field of Mg/steel lap joints was simulated to analyze hole defects generated during the welding process.Hole defects can be eliminated by changing the spindle deflection angle,and the shear force decreased.Excessive spindle deflection can also lead to failure to form a stable joint.Hole defects were removed because the spindle deflection angle reduced the interfacial reaction temperature,and a solid-state welding joint was formed,which resulted in an absence of fusion-brazing welding hole formation. 展开更多
关键词 Mg/steel Lap joint Pinless friction stir spot welding Hole inhibition Simulation
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Virulence arresting drug discovery by strategies targeting bacterial virulence:Mainly focusing on quorum-sensing interference and biofilm inhibition 认领 引用
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作者 Lan Lu Tianyang Yu +11 位作者 Hongping Wang Xingtong Zhu Li Liao Jie Zhu Xiaobo Wang Andi Yang Chen Yang Yuping Zhang Yulin Zhang Kun Zou Xiaorong Yang Mingxing Li 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第12期2764-2783,共20页
The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems,demanding urgent therapeutic interventions.Microorganisms exhibit diverse resistance mechanisms against va... The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems,demanding urgent therapeutic interventions.Microorganisms exhibit diverse resistance mechanisms against various classes of antibiotics,highlighting the urgent need to discover novel antimicrobial agents for combating bacterial infections.Anti-virulence therapy has emerged as a promising therapeutic strategy that neutralizes pathogens by targeting their virulence determinants.The strategies for screening virulence arresting drugs(VADs)in bacteria represent a multifaceted approach that involves elucidating molecular pathogenesis mechanisms of bacterial pathogenicity,identifying evolutionarily conserved virulence factors across different pathogens,and employing integrated approaches combining in silico prediction with experimental validation.Recent technological advancements have established standardized protocols for effective identification and validation of anti-virulence compounds.This review systematically examines contemporary screening methodologies,primarily focusing on quorum-sensing disruption and biofilm suppression strategies,including in silico screening,activity-based screening with bioassays,in vitro and in vivo models.Additionally,we emphasize the imperative for standardized preclinical validation through physiologically relevant animal models,while proposing framework recommendations for developing next-generation VAD screening platforms.This synthesis not only outlines current best practices but also proposes innovative avenues for future antimicrobial discovery research. 展开更多
关键词 Virulence arresting drugs Bacterial virulence factors Quorum-sensing interference Biofilm inhibition Anti-virulence therapy
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Solidification cracking inhibition mechanism of 2024 Al alloy during oscillating laser-arc hybrid welding based on Zr-core-Al-shell wire 认领 引用
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作者 Jun Jin Shaoning Geng +3 位作者 Ping Jiang Liangyuan Ren Chu Han Yuantai Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第14期153-168,共16页
Solidification cracking(SC)of 2024 high-strength aluminium alloy during fusion welding or additive manufacturing has been a long-term issue.In this work,crack-free weld could be obtained using a Zr-core-Alshell wire(Z... Solidification cracking(SC)of 2024 high-strength aluminium alloy during fusion welding or additive manufacturing has been a long-term issue.In this work,crack-free weld could be obtained using a Zr-core-Alshell wire(ZCASW filler material,a novel filler)coupled with an oscillating laser-arc hybrid welding process,and we investigated the solidification cracking susceptibility(SCS)and cracking behavior of AA2024 weld fabricated with different filler materials.The cracking inhibition mechanism of the weld fabricated with ZCASW filler material was elucidated by combined experiments and phase-field simulation.The results show that the effectiveness of filler materials in reducing the SC gradually improves in the order of ER2319 filler material<ER4043 filler material<ZCASW filler material.The main cracking(when using the ER2319 filler material)branches and the micro cracking branches interact with each other to produce cracking coalescence,which aggravates the cracking propagation.The formation of the Al3 Zr phase(when using the ZCASW filler material)promotes heterogeneous nucleation of α-Al,thereby resulting in finer and equiaxed non-dendrite structures,which shortens the liquid phase channels and decreases cracking susceptibility index|d T/d(fs)1/2|(T is temperature and fs is solidification fraction)at final solidification.A higher proportion(7.65%area fraction)of inter-dendrite phase with spherical distribution state,a shorter(8.6 mm liquid channel length)inter-dendrite phase coupled with round non-dendrite structure(6μm dendrite size)effectively inhibit the SC.The present study can be a useful database for welding and additive manufacturing of AA2024. 展开更多
关键词 2024 aluminium alloy Filler materials Solidification cracking susceptibility Cracking behavior Cracking inhibition mechanism
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Fluorescence sensor based on IFE between AEP@UCNPs and oxTMB for the determination of Cd2+in paddy rice combined with HRP enzyme inhibition mechanism 认领 引用
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作者 Haizhen Ding Shuai Hou +6 位作者 Siqi Zhao Liping Guo Ao Sun Qiuhui Hu Leiqing Pan Qiang Liu Chao Ding 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第1期154-160,共7页
Cadmium ion(Cd2+)detection technology plays a prominent role in food safety and human health.Herein,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescenc... Cadmium ion(Cd2+)detection technology plays a prominent role in food safety and human health.Herein,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescence sensor for quantitative detection of Cd2+in paddy rice based on inner filter effect(IFE)combined with enzyme inhibition mechanism.The AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine(oxTMB)catalyzed by horseradish peroxidase(HRP)enzymes.Without addition of Cd2+,the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and oxTMB.With addition of Cd2+,HRP enzyme activity was inhibited by Cd2+,leading to the decreased oxTMB,resulting in the enhance upconversion fluorescence intensity.As a result,the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd2+in a wide range from 0.5μmol/L to 6μmol/L and the limit of detection(LOD)was 24.6 n mol/L.In addition,our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd2+detection in paddy rice in 30 min. 展开更多
关键词 Paddy rice Cd2+ Enzyme inhibition Upconversion nanoparticles(UCNPs) Inner filter effect(IFE)
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Manganese-based nano-delivery system for sensitized anti-tumor immunotherapy via combined autophagy inhibition 认领 引用
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作者 Huijuan Zhang Chenglin Liang +3 位作者 Xinyi Ding Meng Zhang Siyu Lu Lin Hou 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第7期484-489,共6页
The stimulator of interferon genes(STING)agonists have been widely applied to active cyclic guanosine monophophate(GMP)-adenosine monophosphate(AMP)synthase(cGAS)-STING signaling for tumor immunotherapy.However,the th... The stimulator of interferon genes(STING)agonists have been widely applied to active cyclic guanosine monophophate(GMP)-adenosine monophosphate(AMP)synthase(cGAS)-STING signaling for tumor immunotherapy.However,the therapeutic effect will be limited by factors such as the rapid degradation of STING protein and the immunosuppressive tumor microenvironment(TME).In this study,we constructed a manganese-based nano drug delivery system(NDDS)loaded with hydroxychloroquine(HCQ)for synergistic autophagy inhibition and STING activation-based immunotherapy.Hyaluronic acid(HA)/MnOOH@HCQ system can be uptake by 4T1 tumor cells via the CD44 receptor-mediated endocytosis.Subsequently,it responded to the acidic and reducing lysosomal microenvironment degradation to release Mn2+and HCQ simultaneously.As a kind of STING agonist,Mn2+can bind to cGAS in tumor cells,activating the cGAS-STING pathway and generating typeⅠ-interferons(IFN-Ⅰ),which helped alleviate the immunosuppressive TME.Meanwhile,HCQ downregulated the autophagy level caused by cGAS-STING pathway to block STING degradation,further sensitizing the cGAS-STING signal.Benefiting from this synergistic mechanism,HA/MnOOH@HCQ demonstrated the best anti-tumor effect with the smallest tumor weight and volume after treatment.Moreover,HA/MnOOH@HCQ also exhibited a good inhibitory effect on lung metastasis.This study provided a new strategy for enhancing cGAS-STING pathway-mediated anti-tumor immunotherapy. 展开更多
关键词 Anti-tumor immunotherapy cGAS-STING signaling Mn2+and HCQ co-delivery Autophagy inhibition TME responsive
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COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+T cell infiltration in NSCLC 认领 引用
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作者 Lin Ma Menglin Bai +3 位作者 Yao Wang Xueying Zhai Jinming Yu Xiangjiao Meng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第12期1537-1543,共7页
Non-small cell lung cancer(NSCLC)is a leading cause of cancer-related mortality worldwide1-3.While radioimmuno-therapy shows promise in boosting antitumor immunity,the clinical outcomes have been inconsistent4 and are... Non-small cell lung cancer(NSCLC)is a leading cause of cancer-related mortality worldwide1-3.While radioimmuno-therapy shows promise in boosting antitumor immunity,the clinical outcomes have been inconsistent4 and are often lim-ited by the immunosuppressive tumor microenvironment(TME).Cyclooxygenase(COX)-2 and the COX-2 downstream product,prostaglandin E2(PGE2),are increasingly implicated in immune escape5,6 but the impact on radioimmunother-apy efficacy has not been explored.TCF1-expressing CD8+T cells demonstrate defining functional properties of progeni-tor-exhausted T cells,including clonal expansion through self-renewal capacity and multipotent differentiation toward terminal effector phenotypes,while maintaining long-term persistence critical for sustaining antitumor immunity7-9.Given the central role in anti-tumor immune maintenance,TCF1+CD8+T cells are likely critical to radioimmunotherapy efficacy10.The role of COX-2 inhibition in enhancing the effi-cacy of radioimmunotherapy efficacy in NSCLC was investi-gated in the current study. 展开更多
关键词 boosting antitumor immunitythe prostaglandin E non small cell lung cancer immune escape TCF CD T cells cox inhibition tumor microenvironment tme cyclooxygenase cox radioimmunotherapy
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