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Corrigendum to“Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation”[J.Pharm.Anal.13(2023)11–23] 认领 引用
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作者 Ningning Wang Entao Li +9 位作者 Huifang Deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期309-311,共3页
The authors regret the unintentional error in the use of the GAPDH band in the original Fig.5C.The corrected figure is provided as the new Fig.5C below.This change does not affect the conclusions of the paper.
关键词 corrected figure inosine anti inflammatory TBK phosphorylation SARS CoV GAPDH acute lung injury gapdh band
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The novel gene BrYL1,encoding an inosine monophosphate dehydrogenase,is involved in chloroplast development in Chinese cabbage 认领 引用
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作者 Shuangjuan Yang Wenhua Zhao +9 位作者 Zhaojun Wang Xiaochun Wei Yanyan Zhao Zhiyong Wang Henan Su Wenjing Zhang Haohui Yang Lin Li Yuxiang Yuan Xiaowei Zhang 《Horticultural Plant Journal》 SCIE CAS CSCD 2025年第6期2281-2284,共4页
Purines are building blocks for DNA and RNA,found as the energy currency of cells(ATP and GTP),used as signaling molecules(cGMP,cAMP and ATP),and served as precursors for synthesizing primary products such as polysacc... Purines are building blocks for DNA and RNA,found as the energy currency of cells(ATP and GTP),used as signaling molecules(cGMP,cAMP and ATP),and served as precursors for synthesizing primary products such as polysaccharides,sucrose,and phospholipids as well as secondary products(Stasolla et al.,2003;Pareek et al.,2020).Thus,the synthesis of purines is a critical pathway in the cells of all living organisms.Purines can be synthesized through two pathways:de novo and salvage(Stasolla et al.,2003).Recent investigations revealed that purine synthesis is vital for the proper development of chloroplasts in plants.In Arabidopsis,CIA1 encodes the enzyme glutamine phosphoribosyl pyrophosphate amidotransferase,which catalyzes the first committed step of purine de novo biosynthesis,the loss-of-function mutant cia1 shows small,pale-green mosaic leaves(Hung et al.,2004).In rice,both VAL1 and GARS encode glycinamide ribonucleotide synthetase that mediates the second step in purine biosynthesis. 展开更多
关键词 inosine monophosphate dehydrogenase signaling molecules cgmpcamp gene chloroplast development secondary products stasolla Chinese cabbage Bryl primary products
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Sensitive determination of inosine RNA modification in single cell by chemical derivatization coupled with mass spectrometry analysis 认领 引用 被引量：6
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作者 Wan-Bing Tao Neng-Bin Xie +2 位作者 Qing-Yun Cheng Yu-Qi Feng Bi-Feng Yuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第10期98-101,共4页
Inosine is a vital RNA modification across three kingdoms of life.It has been demonstrated that inosine plays important roles in modulation of the fate of RNAs.In the current study,we developed a highly sensitive meth... Inosine is a vital RNA modification across three kingdoms of life.It has been demonstrated that inosine plays important roles in modulation of the fate of RNAs.In the current study,we developed a highly sensitive method to determine inosine in a single cell by N-cyclohexyl-N’-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate(CMCT)derivatization in combination with mass spectrometry analysis.The results showed that the detection sensitivity of inosine was increased by 556-fold after CMCT derivatization,with the limit of detection(LOD)being 4.5 amol.With the established method,we could detect inosine from 13.0 pg of total RNA of HEK293T cells.Meanwhile,inosine in RNA from a single cell could also be clearly detected due to the improved detection sensitivity.Moreover,we found the level of inosine in RNA of sleep-deprived mice was significantly increased compared to the control mice,indicating that inosine is associated with sleep behavior and might be a potential indicator of sleep disorder.Taken together,the chemical derivatization coupled with mass spectrometry analysis offers a valuable tool in determination of endogenous RNA modifications in a single cell,which should benefit the functional study of RNA modification in rare clinical samples. 展开更多
关键词 Inosine RNA modification CMCT Derivatization Mass spectrometry Single cell
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Highly-sensitive electrochemiluminescence biosensor for detection of inosine monophosphate in meat based on graphdiyne/AuNPs/luminol nanocomposites 认领 引用 被引量：3
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作者 Jing Liu Yizhong Shen +4 位作者 Guangxian Wang Yaodong Xiang Yemin Guo Xia Sun Yuan Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第4期1149-1156,共8页
Inosine monophosphate(IMP),as a critical umami substance,is one of the most important indicators for evaluating the quality of meat products.Here,a sensitive electrochemiluminescence(ECL)biosensor based on graphdiyne(... Inosine monophosphate(IMP),as a critical umami substance,is one of the most important indicators for evaluating the quality of meat products.Here,a sensitive electrochemiluminescence(ECL)biosensor based on graphdiyne(GDY)/AuNPs/luminol nanocomposites was constructed to detect IMP.The GDY/AuNPs/luminol nanocomposites were synthesized by using simple one-pot method.GDY utilized its 2D framework to disperse and fix gold nanoparticles,which inhibited the agglomeration of gold nanoparticles and greatly improved its stability and catalytic properties.Importantly,GDY/AuNPs/luminol nanocomposites showed excellent catalytic ability and superior ECL activity towards luminol-H2O2 systems due to the synergistic effect of GDY and AuNPs.Under optimal conditions,the prepared biosensor exhibited a wide linear range from 0.01 g/L to 20 g/L,a satisfactory limit detection of 0.0013 g/L,as well as an excellent specificity.Moreover,we carried out the precise analysis of IMP in actual meat samples with acceptable results compared to the liquid chromatography.We believe that this work could offer an efficient ECL platform for accurate and reliable report of IMP levels,which is significant for maintaining food quality and safety. 展开更多
关键词 Inosine monophosphate(IMP) Electrochemiluminescence Graphdiyne(GDY)/AuNPs/luminol Bienzyme
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Characteristics of Deposition of Inosine Monophosphate(IMP) and Intramuscular Fat(IMF) in Muscles of Jinghai Yellow Chicken and Its Crossbreeds 认领 引用 被引量：4
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作者 谢恺舟 李爱华 +7 位作者 孙瑛瑛 陈学森 黄玉萍 张小杰 赵敏 张跟喜 戴国俊 王金玉 《Agricultural Science & Technology》 CAS 2013年第1期144-148,154,共5页
[Objective] This study aimed to investigate the characteristics of deposition of inosine monophosphate （IMP） and intramuscular fat （IMF） in muscles of Jinghai yellow chickens and its crossbred.[Method] The charact... [Objective] This study aimed to investigate the characteristics of deposition of inosine monophosphate （IMP） and intramuscular fat （IMF） in muscles of Jinghai yellow chickens and its crossbred.[Method] The characteristics of IMP and IMF deposition of 112-day-old Jinghai yellow chickens （J×J） and its two different 70-day- old crossbreeds （J×B and B×B） were analyzed. The IMP content in breast muscle and leg muscle were determined by HPLC. [Result] The contents of IMP and cor- rected inosine monophosphate （IMPc） in breast muscle were significantly or ex- tremely significantly higher than that in leg muscle of the chickens in the three groups whether in male or female chickens （P〈0.05 or P〈0.01）. There were no sig- nificant difference in the contents of IMP and IMPc between hens and roosters （P〉 0.05）. The fresh degree of breast muscle and leg muscle was 96,11%-98.16% and 87.22%-93.07%, respectively. And the fresh degree of breast muscle was higher than that of leg muscle. In the three groups, the IMF content in leg muscle was significantly higher than that in breast muscle whether in male or female chickens （P〈0.05）. The contents of IMF in breast muscle and leg muscle were 0.36%-0.75% and 1.84%-2.38%, respectively. The iMP content in breast muscle of chickens in Bx J group was extremely significantly higher than that in breast muscle of chickens in JxJ group （P〈0.01）, but the contents of IMPc and iMF of breast muscle and leg muscle of the chickens in the three groups had no significant difference （P〉0.05）. [Conclusion] To sum up, the freshness and flavor significantly differ between the breast muscle and leg muscle of chickens, but show no significant difference among the three groups. 展开更多
关键词 Crossbred combinations Muscles Inosine monophosphate （IMP） lintra- muscular fat （IMF） Deposition Jinghai yellow chicken
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6-Thioguanine incorporates into RNA and induces adenosine-to-inosine editing in acute lymphoblastic leukemia cells 认领 引用 被引量：3
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作者 Xue-Jiao You Lin Li +3 位作者 Tong-Tong Ji Neng-Bin Xie Bi-Feng Yuan Yu-Qi Feng 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第1期539-543,共5页
6-Thioguanine(6TG)is a widely used chemotherapeutic agent for the treatment of a variety of human diseases including acute lymphoblastic leukemia.After entry into cells,6TG is metabolically converted into 6-thioguanos... 6-Thioguanine(6TG)is a widely used chemotherapeutic agent for the treatment of a variety of human diseases including acute lymphoblastic leukemia.After entry into cells,6TG is metabolically converted into 6-thioguanosine(SG)nucleotide that can be incorporated into the genome during DNA replication.SG in genomic DNA could induce cell death by triggering the post-replicative mismatch repair(MMR)pathway.Meanwhile,incorporation of 6TG into the Cp G sites could perturb the global DNA methylation and gene regulation.However,the effect of 6TG on RNA modifications is still unknown.Adenosine-toinosine(A-to-I)editing in RNA is one of the most common post-transcriptional modifications in mammals and there is growing evidence showing the significant alteration of A-to-I RNA editing in tumor tissues compared to normal tissues.In the current study,we examined the incorporation of 6TG into RNA and investigated its effect on A-to-I editing of bladder cancer-associated protein(BLCAP)transcript in acute lymphoblastic leukemia cells.The results demonstrated that SG could be incorporated into various RNA species,with m RNA having the most abundant SG.In addition,the results showed 6TG treatment elevated A-to-I editing in BLCAP transcript through upregulating adenosine deaminase 2 acting on RNA(ADAR2),which eventually contributes to the decreased cell viability.This study highlights a new mechanism of the cytotoxicity of 6TG in inducing cell death. 展开更多
关键词 6-Thioguanine RNA modification Inosine Leukemia Mass spectrometry
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Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients 认领 引用 被引量：2
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作者 Walaa H Ahmed Norihiro Furusyo +5 位作者 Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi 《World Journal of Gastroenterology》 SCIE CAS 2013年第9期1387-1395,共9页
AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all pati... AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. 展开更多
关键词 Anemia Dose reduction Hepatitis C Inosine triphosphate Ribavirin Rs1127354
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ADSL, AMPD1, and ATIC Expression Levels in Muscle and Their Correlations with Muscle Inosine Monophosphate Content in Dapulian and Hybridized Pig Species 认领 引用 被引量：3
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作者 Rongsheng Zhu Yanping Wang +4 位作者 Huaizhong Wang Song Lin Shouli Sun Baohua Huang Hongmei Hu 《Open Journal of Animal Sciences》 2017年第4期393-404,共12页
We investigated the relationship between muscle inosine monophosphate (IMP) content and mRNA levels of ADSL, AMPD1, and ATIC in Dapulian (DPL), Landrace × Dapulian (LDPL), and Duroc × Landrace × Dapulia... We investigated the relationship between muscle inosine monophosphate (IMP) content and mRNA levels of ADSL, AMPD1, and ATIC in Dapulian (DPL), Landrace × Dapulian (LDPL), and Duroc × Landrace × Dapulian (DLDPL) hybridized pigs. Methods: The total RNA in longissimus dorsi was isolated from Dapulian (DPL), Landrace × Dapulian (LDPL) and Duroc × Landrace × Dapulian (DLDPL) hybridized pigs, weighed about 95.0 kg, n = 8/species. The internal genes with highest stability (YWHAZ and RPL4) were chosen from 11 common internal genes using Quantitative real-time PCR (qPCR) and geNorm software. The mRNA levels of ADSL, AMPD1 and ATIC genes were corrected with YWHAZ and RPL4 genes. The muscular IMP content was determined by HPLC. The muscular IMP content in DPL was higher than that in LDPL and DLDPL, 25.00% (p 0.05) and 15.56% (p > 0.05), respectively. The muscular mRNA level of ADSL gene in DPL and LDPL was higher than that in DLDPL, 24.14% and 12.07%, respectively (p 0.05). The muscular mRNA level of ATIC gene in DPL and LDPL was higher than that in DLDPL, 66.67% and 33.33%, respectively (p 0.05). The muscular mRNA level of AMPD1 gene in DPL and LDPL was higher than that in DLDPL, 14.49% and 33.26%, respectively. Furthermore, the IMP content was positively correlated with the mRNA level of ADSL, AMPD1 and ATIC genes, respectively (p 0.05). The mRNA level of ADSL gene was highly related to that of AMPD1 and ATIC gene, respectively (p 0.01), while that of AMPD1 gene was not strongly correlated with that of ATIC gene (p > 0.05). The muscular mRNA level of AMPD1, ADSL and ATIC genes and the muscular IMP content in DPL were highest, followed by those in LDPL and DLDPL. The muscular IMP content was positively correlated with the muscular mRNA level of ADSL, AMPD1 and ATIC genes, respectively. 展开更多
关键词 Pigs ADSL Gene AMPD1 Gene ATIC Gene Correlation Inosine Monophosphate
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CHEMICAL CONVERSION OF INOSINE INTO 6-(2-METHYL PHENOXY)-PURLNENUCLEOSIDE DERIVATIVES 认领 引用
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作者 Li Ya ZHU Qi Dong ZHANG Zi Yun LIN Institute of Materia Medica,Chinese Academy of Medical Sciences Beijing 100050 《Chinese Chemical Letters》 SCIE EI CAS 1993年第10期851-852,共2页
A 6-pyridinium salt(2)was obtalned from 2',3',5'-tri-O-acetyhnosine by use of phosphoryl chloride as the condensmg agent.The conversion of salt(2)into 6-(2- methylphenoxy)-purinenucleoside(3)denvatives und... A 6-pyridinium salt(2)was obtalned from 2',3',5'-tri-O-acetyhnosine by use of phosphoryl chloride as the condensmg agent.The conversion of salt(2)into 6-(2- methylphenoxy)-purinenucleoside(3)denvatives under mild condition is also described. 展开更多
关键词 OH CHEMICAL CONVERSION OF INOSINE INTO 6 METHYL PHENOXY PURLNENUCLEOSIDE DERIVATIVES
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Deposition Pattern of Inosine Monophosphate( IMP) in Pig Muscle during Cold Storage 认领 引用
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作者 Zhu Rongsheng Wang Huaizhong +2 位作者 Lin Song Wang Yanping Hu Hongmei 《Animal Husbandry and Feed Science》 CAS 2017年第4期197-199,218,共3页
[ Objective] The paper was to investigate the degradation and deposition changes of inosine monophosphate （IMP） and its metabolites in muscle of lean pigs and crossbreeding pigs under cold storage condition at 4℃. ... [ Objective] The paper was to investigate the degradation and deposition changes of inosine monophosphate （IMP） and its metabolites in muscle of lean pigs and crossbreeding pigs under cold storage condition at 4℃. [ Method] The contents of IMP and its metabolites in longissimus dorsi of lean pigs and crossbreeding pigs were determined by HPLC method. [ Result] Duroc, Landrace, Yorkshire and DLY pigs shared the same degradation and deposition pattern on IMP, inosine and hypoxanthine. On the second day of cold storage, the content of IMP reached the maximum value, which increased by 0.4% - 15.32% compared with the first day, and then it started to decline. On the fourth day of cold storage, the content of IMP significantly reduced by 23.81% - 39.06% than that on the second day. On the fifth and sixth day of cold storage, the content of IMP kept on falling down slowly and maintained around 1.0 mg/g. While the contents of inosine and hypoxanthine showed an increasing tendency with the extension of cold storage time. [ Conclusion ] Lean pigs Duroc, Landraee and Yorkshire and DLY three- way crossbreeding pigs shared the same degradation and deposition pattern on IMP and its metabolites. With the extension of cold storage, the content of IMP first increased then gradually decreased; while inosine and hypoxanthine gradually increased, and the difference among breeds was not significant. 展开更多
关键词 Pig muscle IMP Inosine Hypoxanthine Deposition pattern
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STUDIES ON INOSINE EXTRACTION BY ION EXCHANGE METHOD 认领 引用
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作者 Huang Xiwen Shi Fang +1 位作者 Zhao Lin Sun He 《Chinese Journal of Reactive Polymers》 1998年第1期39-48,共10页
The adsorption characteristics of inosine from fermentation solution on anion exchange resin under the condition of different PH, resin type are investigated. Besides 3 the desorption conditions are studied under diff... The adsorption characteristics of inosine from fermentation solution on anion exchange resin under the condition of different PH, resin type are investigated. Besides 3 the desorption conditions are studied under different temperature.The adsorption and desorption mechanism are described to obtain the optimumtechnological condition of inosine extraction. 展开更多
关键词 Inosine Ion - exchange Extraction
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Ruminal microbiota-derived inosine alleviates metabolic disorders in dairy cows supplemented with grape seed extract 认领 引用
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作者 Qi Shao Xinwei Li +11 位作者 Guojin Li Lin Cai Muhammad Usman Juan J.Loor Zhiyuan Fang Meng Chen Chenxu Li Lingxue Ju Cai Zhang Yuanxiao Li Haihua Feng Xiliang Du 《Animal Nutrition》 SCIE CAS CSCD 2025年第4期1-16,共16页
Ruminal microbiota and their metabolites can shape host metabolic responses.Grape seed extract(GSE)can modulate ruminal microbiota profiles and metabolites in vitro,thus,underscoring their potential benefits on energy... Ruminal microbiota and their metabolites can shape host metabolic responses.Grape seed extract(GSE)can modulate ruminal microbiota profiles and metabolites in vitro,thus,underscoring their potential benefits on energy metabolism in dairy cows.In this study,Chinese Holstein cows were randomly divided into two groups(n=10 per group)with or without dietary supplementation of GSE(15 g/d per cow)from3 to 3 wk relative to calving.The results showed that GSE supplementation led to increased fat corrected milk yield(P=0.003),feed efficiency(P=0.045)and reduced milk somatic cell count(P=0.031).In addition,GSE resulted in greater overall serum glucose(P=0.011)and lower nonesterified fatty acids(P0.5,P<0.05).Furthermore,just as GSE in vivo,exogenous inosine treatment elicited similar effects on energy metabolism and inflammation both in vitro(1μmol/L,hepatocytes and adipocytes)and in dairy cows with ketosis(8 mg/kg per day,n=5)(P<0.05).Overall,results underscore a beneficial effect of ruminal microbiota-derived inosine in maintaining metabolic homeostasis postcalving.Thus,dietary GSE supplementation may improve energy metabolism and inflammatory state in dairy cows by enhancing ruminal-derived inosine production.Feeding GSE and inosine can be a potential strategy to alleviate health problems and optimize productivity in dairy cows during the transition period. 展开更多
关键词 Ruminal microbiota Grape seed extract Inosine Metabolic disorder Ketosis
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Microbial metabolite facilitates virus control:inosine and T cells curb early-life influenza infection 认领 引用
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作者 Lisa Sevenich Thi Trang Le Lukas F.Mager 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2025年第10期5378-5380,共3页
In a recent publication in Cell,Stevens et al.uncovered that microbiota disruptions reduced inosine levels and impaired CD8+T cell immunity against influenza infection in early life.Treatment with inosine-producing... In a recent publication in Cell,Stevens et al.uncovered that microbiota disruptions reduced inosine levels and impaired CD8+T cell immunity against influenza infection in early life.Treatment with inosine-producing bacteria or inosine alone restored T cell responsiveness through a nuclear factor interleukin 3(NFIL3)-dependent mechanism. 展开更多
关键词 microbiota disruptions t cells influenza infection microbial metabolite nfil dependent mechanism t cell responsiveness inosine
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Correction to:Adenosine-to-inosine RNA editing in cancer:molecular mechanisms and downstream targets 认领 引用
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《Protein & Cell》 SCIE CAS CSCD 2025年第9期835-836,共2页
This is a correction to:Hao Cheng,Jun Yu,Chi Chun Wong,Adenosine-to-inosine RNA editing in cancer:molecular mechanisms and downstream targets,Protein&Cell,2024;http://gffzzd3cc09b8251d45dfswb6vcbpwkp6w6xb6.ffgz.tsg.suse.edu.cn/10.1093/procel/pwae039 In the origina... This is a correction to:Hao Cheng,Jun Yu,Chi Chun Wong,Adenosine-to-inosine RNA editing in cancer:molecular mechanisms and downstream targets,Protein&Cell,2024;http://gffzzd3cc09b8251d45dfswb6vcbpwkp6w6xb6.ffgz.tsg.suse.edu.cn/10.1093/procel/pwae039 In the originally published version of the manuscript there were errors in Figure 2.In panel H,text should read:"Loses capacity"instead of:"oses capacity";a redundant letter"I"that was highlighted should be removed. 展开更多
关键词 adenosine inosine RNA editing molecular mechanisms downstream targets cancer
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism 认领 引用 被引量：1
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作者 Akiko Ogawa 《四川生理科学杂志》 2025年第8期1719-1719,共1页
RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RN... RNA contains diverse post-transcriptional modifications,and its catabolic breakdown yields numerous modified nucleosides requiring correct processing,but the mechanisms remain unknown.Here,we demonstrate that three RNA-derived modified adenosines,N6-methyladenosine(m6A),N6,N6-dimethyladenosine(m6,6A),and N6-isopentenyladenosine(i6A),are sequentially metabolized into inosine monophosphate(IMP)to mitigate their intrinsic cytotoxicity. 展开更多
关键词 adenosine kinase modified adenosines modified adenosinesn methyladenosine m n n dimethyladenosine m catabolic breakdown modified nucleosides detoxification inosine monophosphate imp adal
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Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia 认领 引用 被引量：5
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作者 Hongyuan Zhao Xiaoyu Chen +4 位作者 Fanqiang Meng Libang Zhou Xinyi Pang Zhaoxin Lu Yingjian Lu 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第4期1379-1390,共12页
Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of it.Lacticaseibacillus rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine de... Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of it.Lacticaseibacillus rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine degradation rate reached 36.3%at 109 CFU/mL for 24 h.LC-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of L.rhamnosus Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and riboflavin.The contents of folic acid and riboflavin were 6.0 and 4.3 fold increased after inosine treatment in the cell-free extracts(CFE).L.rhamnosus Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase(XOD)inhibition and ATP-binding cassette subfamily G member 2(ABCG2)promotion,both of which are responsible for uric acid(UA)synthesis and secretion in HepG2 and Caco2 cells,respectively.The in vivo results showed that the serum UA level decreased from 236.28 to 149.28μmol/L after 8 weeks of oral administration of L.rhamnosus Fmb14 in inosine-induced hyperuricemia model mice.Our results revealed that L.rhamnosus Fmb14 has a potential as a biological therapeutic agent in hyperuricemia prevention. 展开更多
关键词 Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Inosine degradation Uric acid metabolism
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Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products 认领 引用 被引量：3
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作者 QIAN Zheng-Ming WU Zi +6 位作者 HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2021年第12期954-960,共7页
An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali... An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali). The sample was ultrasonically extracted using 0.5% phosphoric acid solutions for 2.5 min. Sample separation was performed on a Poroshell SB-Aq column(50 mm × 4.6 mm, 2.7 μm) using eco-friendly mobile phase consisting of formic acid and ammonium formate aqueous solution at a flow rate of 1.0 m L·min;. The detection wavelength was 260 nm. The developed HPLC method showed good linearity with correlation coefficients of 1.0000 in the test range. Good precision, repeatability and stability of this method were also observed(RSD ≤ 2.81%).The recovery ranged from 91.84%-105.19%(RSD ≤ 2.59%). Compared with reported methods, the current method did not use harmful organic solvent and took only 10.5 min. It obtained a high eco-score of 91 by the "Analytical Eco-Scale" tool. The developed method is eco-friendly and fast, which is suitable for the quality evaluation of Cordyceps and related products. 展开更多
关键词 Adenosine Inosine Guanosine Uridine Cordyceps
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Role of genetic polymorphisms in hepatitis C virus chronic infection 认领 引用 被引量：2
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作者 Nicola Coppola Mariantonietta Pisaturo +2 位作者 Caterina Sagnelli Lorenzo Onorato Evangelista Sagnelli 《World Journal of Clinical Cases》 SCIE 2015年第9期807-822,共16页
AIM: To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C(CHC).METHODS: We conducted an electronic search on the Pub Med and... AIM: To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C(CHC).METHODS: We conducted an electronic search on the Pub Med and MEDLINE(2000-2014) databases and Cochrane library(2000-2014). A total of 73 articles were retrieved and their data were extensively evaluated and discussed by the authors and then analyzed in this review article.RESULTS: Several studies associated polymorphisms in the interleukin 28 B gene on chromosome 19(19q13.13) with a spontaneous viral clearance in acute hepatitis C and with the response to pegylated interferon(PegIFN)-based treatment in chronic hepatitis C patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect hepatitis C virus-genotype-1 CHC patients from ribavirin-induced anemia, and other studies that a polymorphism in the patatin-like phospholipase domain-containing protein 3 was associated with hepatic steatosis in CHC patients. Although not conclusive, some investigations suggested that the vitamin D-associated polymorphisms play an important role in the achievement of sustained virologic response in CHC patients treated with Peg-IFN-based antiviral therapy. Several other polymorphisms have been investigated to ascertain their possible impact on the natural history and on the response to treatment in patients with CHC, but the data are preliminary and warrant confirmation. CONCLUSION: Several genetic polymorphisms seem to influence the clinical course and the response to antiviral treatment in patients with CHC, suggesting individualized follow up and treatment strategies. 展开更多
关键词 Single nucleotide polymorphism Hepatitis C virus infection Interleukin 28B Inosine triphosphate pyrophosphatase Patatin-like phospholipase domaincontaining protein 3
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Epitranscriptomics of cancer 认领 引用 被引量：3
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作者 Marina Tusup Thomas Kundig Steve Pascolo 《World Journal of Clinical Oncology》 2018年第3期42-55,共14页
The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opp... The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer. 展开更多
关键词 RNA modifications N6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine Pseudouridine Inosine
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Treatment of 104 Cases of Chemotherapy-Induced Leukopenia by Injection of Drugs into Zusanli 认领 引用
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作者 尹先哲 尹德印 +2 位作者 刘新群 丁旭萌 周永生 《Journal of Traditional Chinese Medicine》 2001年第1期27-28,共2页
From April 1992 to April 1998, 104 cases of chemotherapy-induced leukopenia were treated by injection into Zusanli (ST 36) with a mixture consisting of dexamethasone, 654-2, ATP and inosine. The therapeutic results we... From April 1992 to April 1998, 104 cases of chemotherapy-induced leukopenia were treated by injection into Zusanli (ST 36) with a mixture consisting of dexamethasone, 654-2, ATP and inosine. The therapeutic results were satisfactory as reported in the following.Clinical Data In this series, all the 127 cases were definitely diagnosed by pathological examination. Of them, 93 were male and 34 female, ranging in age from 12 to 75 years. 38 cases were carcinoma of esophagus, 22 carcinoma of cardia of stomach, 21 cancer of lung, 11 hepatic carcinoma, 8 lymphoma, 8 mammary cancer, 7 carcinoma of colon, and 12 other kinds of the tumors. Leukocyte count was below 4.0×109/L in all the patients after being treated by chemotherapy. 展开更多
关键词 Acupuncture Points Adenosine Triphosphate Adolescent Adult Aged Antineoplastic Agents Carcinoma, Squamous Cell Child Dexamethasone Esophageal Neoplasms Female Humans Injections Inosine Leukopenia Male Middle Aged Solanaceous Alkaloids Stomach Neoplasms
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