期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到33,503篇文章
< 1 2 … 250 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Establishing a role of the insulin receptor in microglia 认领 引用
1
作者 William A.Banks Elizabeth M.Rhea 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3517-3518,共2页
Brain insulin resistance(BIR)is a prevalent detrimental feature of Alzheimer’s disease(AD)and all-cause dementia.Therapies designed to activate insulin signaling and enhance insulin receptor sensitivity have proven b... Brain insulin resistance(BIR)is a prevalent detrimental feature of Alzheimer’s disease(AD)and all-cause dementia.Therapies designed to activate insulin signaling and enhance insulin receptor sensitivity have proven beneficial for cognitive enhancement in pre-clinical models,non-human primates,and humans.BIR encompasses dysregulated brain insulin signaling,which is either due to insulin receptor resistance,reduced insulin receptor levels,or reduced levels of insulin in the brain,affecting processes involved in AD development and progression. 展开更多
关键词 brain insulin resistance bir dysregulated brain insulin signalingwhich enhance insulin receptor sensitivity brain insulin resistance activate insulin signaling insulin receptor microglia cognitive enhancement
暂未订购 下载PDF
Brain insulin resistance and neuropsychiatric symptoms in Alzheimer's disease:A role for dopamine signaling 认领 引用
2
作者 Anastasia Kontogianni Hongbin Yang Wenqiang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1995-1996,共2页
Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central com... Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central complications.Type 2 diabetes mellitus(T2DM),the most prevalent type of diabetes,affects more than 38 million individuals in the United States(approximately 1 in 10)and is defined by chronic hyperglycemia and insulin resistance,which refers to a reduced cellular response to insulin. 展开更多
关键词 reduced cellular response insulin dopamine signaling insulin resistancewhich metabolic disorder type diabetes mellitus brain insulin resistance Alzheimers disease neuropsychiatric symptoms
暂未订购 下载PDF
Overview of insulin: more than a hormone for controlling glucose level 认领 引用
3
作者 Izmailova Regina Fang Tong 《Biomedical Engineering Communications》 CAS 2025年第2期29-39,共11页
Insulin is a peptide hormone secreted by pancreaticβ-cells,which plays a key role in regulating glucose metabolism and is the only hormone in the body capable of lowering blood glucose level.The development of insuli... Insulin is a peptide hormone secreted by pancreaticβ-cells,which plays a key role in regulating glucose metabolism and is the only hormone in the body capable of lowering blood glucose level.The development of insulin preparations has undergone nearly 100 years of history,from early animal insulin extraction to modern synthetic insulin and insulin analogs,which have greatly advanced the treatment of diabetes.The insulin receptor has a wide distribution in the body,and its activation leads to intracellular signaling mainly through two pathways,PI3K/Akt and Ras/MAPK.Clinically,insulin is crucial in the treatment and management of diabetes and its complications,especially in the cases where oral medications fail to control blood glucose.The role of insulin is not limited to the regulation of blood glucose but has a wide range of functions throughout the body,such as regulation of mitochondrial function and metabolism,the promotion of protein synthesis,adipogenesis,and cellular proliferation.However,insulin overdose may lead to severe hypoglycemia,which,if left untreated,poses the risk of irreversible neurological damage or even fatality.In this paper,we review the history of the development of insulin preparations,the molecular structure of insulin,the biological processes initiated by insulin and insulin deficiencyesistance.The overview of side effects from insulin is also included in this review.We assume that future research could focus on refining insulin analogs for greater therapeutic precision,minimizing side effects,and extending benefits beyond glycemic control.Exploring insulin’s additional effects may unlock potential applications in treating multiple diseases. 展开更多
关键词 insulin insulin preparation insulin receptor biological process of insulin functions of insulin insulin deficiency and resistance side effects of insulin
暂未订购 下载PDF
Duplicated paralog of insulin receptor functions distinctively in locust reproduction for high fecundity 认领 引用
4
作者 Libin Yang Yan Liu +1 位作者 Zhongxia Wu Shutang Zhou 《Insect Science》 SCIE CAS CSCD 2026年第4期1383-1395,共13页
Insulin receptor(InR)mediates the highly conserved insulin/insulin-like growth factor signaling pathway that regulates a broad range of life-history traits.Most insects encode 2 InR paralogs,but their functional diver... Insulin receptor(InR)mediates the highly conserved insulin/insulin-like growth factor signaling pathway that regulates a broad range of life-history traits.Most insects encode 2 InR paralogs,but their functional divergence and redundancy remain to be explored.Here,we pursued the functionality of 2 InRs,LmInR1,and LmInR2,in the migratory locust Locusta migratoria.LmInRl is clustered into the clade of ancestral InR,and LmInR2 belongs to the clade of InR gene duplication.While LmInRl expression was at the highest levels in nymphal stage and adult ovary,LmInR2 was predominantly expressed in adult fat body.Loss of LmInR1 function led to defective nymph-adult transition and reproduction.LmInR2 depletion had little effect on metamorphosis,but caused severe defects in female reproduction,including remarkable reduction of Vitellogenin(Vg)expression and arrested egg development.Interestingly,LmInR1 expression responded to lower levels of glucose,whereas LmInR2 was expressed in response to increasing concentrations of glucose.Moreover,the expression of LmInR2 but not LmInRl was responsive to juvenile hormone(JH)and its receptor.The results suggest that LmInR2 has evolved neofunctionalization for massive Vg synthesis required for synchronous maturation of dozens of oocytes in a high-fecundity insect.This study reveals a novel aspect of differential functions of InR paralogs and provides new insights into understanding of the insulin signaling cascade in insects. 展开更多
关键词 glucose insulin insulin receptor juvenile hormone metamorphosis reproduction
暂未订购 下载PDF
Nuciferine ameliorates cognitive impairment and insulin resistance in T2DM by targeting the insulin receptor and activating PI3K/AKT signaling 认领 引用
5
作者 Miao Zheng Can Wang +3 位作者 Jiayi Liu Yi Xia Xinyue Zhang Lili Gu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第7期819-831,共13页
Insulin resistance is a hallmark of type 2 diabetes(T2DM)and can increase the risk of cognitive impairment,including Alzheimer’s disease.Nuciferine,an alkaloid derived from lotus leaves,shows neuroprotective effects.... Insulin resistance is a hallmark of type 2 diabetes(T2DM)and can increase the risk of cognitive impairment,including Alzheimer’s disease.Nuciferine,an alkaloid derived from lotus leaves,shows neuroprotective effects.This study investigated nuciferine’s protective role in T2DM-induced cognitive impairment(T2DM-CI)and its mechanisms.Mouse models were created using high-fat diets and streptozotocin,along with high glucose-induced HT-22 cells.Nuciferine reduced blood glucose,improved cognitive function,and mitigated glial cell activation,neuron and synapse loss in T2DM mice.It enhanced insulin signaling by increasing protein levels of IR,IRS1,and IGF-1R,reversing PI3K and AKT phosphorylation,inhibiting GSK3βactivity,and reducing hyperphosphorylated Tau in HT-22 cells and T2DM mice.mRNA levels of these molecules matched their protein levels.Further studies revealed that nuciferine directly interacts with IR,knocking out IR abolished its effects on the PI3K/AKT pathway.Thus,nuciferine activates the PI3K/AKT pathway via IR,improving insulin resistance and slowing T2DM-CI progression. 展开更多
关键词 Nuciferine T2DM-CI PI3K/AKT pathway Insulin receptor Neuroprotection Insulin resistance
暂未订购 下载PDF
Trans-activator of transcription-pre-B-cell leukemia transcription factor 1 alleviates Alzheimer's disease by reducing neuronal insulin resistance and restoring energy homeostasis 认领 引用
6
作者 Xiangyuan Meng Zinan Liu +14 位作者 Zhenhu Zhao Lei Chen Siyao Li Qi Song Ruihan Guo Xin Zhang Fanlei Meng Hui Zhang Li Tan Xinpeng Liu Yujie Wang Feng Zhong Run Liu Tianlin Gao Jinyu Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4390-4405,共16页
Alzheimer's disease is characterized by hippocampal neuronal apoptosis,which leads to cognitive decline.The pathophysiology of Alzheimer's disease is largely driven by disrupted cellular metabolism and insuffi... Alzheimer's disease is characterized by hippocampal neuronal apoptosis,which leads to cognitive decline.The pathophysiology of Alzheimer's disease is largely driven by disrupted cellular metabolism and insufficient neuronal energy supply.However,current treatments for Alzheimer's disease remain limited because of side effects and disease complexity.Increasing evidence suggests that amyloid-βoligomer-induced neuronal insulin resistance and metabolic dysfunction play key roles in Alzheimer's disease progression,yet their underlying mechanisms and therapeutic strategies remain unclear.In this translational preclinical study,we combined a case-control analysis,in vitro cell assays,and in vivo experiments using amyloid precursor protein/presenilin 1 transgenic mice to investigate whether transcriptional regulation of key regulatory factors restores neuronal energy supply and improves Alzheimer's disease-induced pathology.The case-control analysis identified pre-B-cell leukemia transcription factor 1 as a crucial regulator of brain metabolic homeostasis in Alzheimer's disease.We developed a blood-brain barrier-permeable trans-activator of transcription-pre-B-cell leukemia transcription factor 1 fusion protein to enhance pre-B-cell leukemia transcription factor 1 expression,with the aim of restoring neuronal energy supply and reducing apoptosis.Mechanistic investigations using Alzheimer's disease models revealed that pre-B-cell leukemia transcription factor 1 transcriptionally upregulates insulin receptor substrate 1 by interacting with its promoter,which resulted in augmented insulin signaling.Trans-activator of transcription-pre-B-cell leukemia transcription factor 1 downregulated PDK4,significantly upregulated the expression of pyruvate dehydrogenase,and promoted mitochondrial oxidative phosphorylation activity,which inhibited the abnormally enhanced glycolytic flux,increased adenosine triphosphate production,and ultimately helped restore neuronal energy homeostasis.Therapeutic administration of trans-activator of transcription-pre-B-cell leukemia transcription factor 1 in amyloid precursor protein/presenilin 1 transgenic mice significantly enhanced cognitive performance,diminished hippocampal neuronal apoptosis,and mitigated amyloid-βdeposition.No significant hepatotoxicity,nephrotoxicity,or other detectable adverse effects were observed within the dose ranges and time windows of administration.Taken together,we identified pre-B-cell leukemia transcription factor 1 as a crucial transcriptional regulator of neuronal energy metabolism in Alzheimer's disease.Moreover,we elucidated the molecular mechanism through which the pre-B-cell leukemia transcription factor 1-insulin receptor substrate 1 signaling axis sustains metabolic homeostasis.Furthermore,we demonstrated that the blood-brain barrier-permeable trans-activator of transcription-pre-B-cell leukemia transcription factor 1 fusion protein constitutes a mechanistically innovative and highly translatable therapeutic strategy for Alzheimer's disease. 展开更多
关键词 Alzheimer’s disease amyloid-beta oligomers amyloid precursor protein/presenilin 1 insulin receptor substrate 1 insulin resistance metabolic reprogramming molecular medicine neuron oxidative phosphorylation pre-B-cell leukemia transcription factor 1
暂未订购 下载PDF
Rabson-Mendenhall syndrome caused by a novel splice-site mutation(c.1123+2 T>C)of insulin receptor:A case report and review of literature 认领 引用
7
作者 Kun Wang Juan Zheng +4 位作者 Long-Chao Gu Rong-Rong Li Xu-Dong Su Jie Bai Lin Liao 《World Journal of Diabetes》 SCIE 2026年第1期211-220,共10页
BACKGROUND Rabson-Mendenhall syndrome(RMS)is an extremely rare monogenic form of diabetes caused by mutations in the insulin receptor(INSR)gene,with only about 50 cases reported worldwide to date.Here,we report a case... BACKGROUND Rabson-Mendenhall syndrome(RMS)is an extremely rare monogenic form of diabetes caused by mutations in the insulin receptor(INSR)gene,with only about 50 cases reported worldwide to date.Here,we report a case of RMS caused by a previously unreported c.1123+2 T>C splice mutation.CASE SUMMARY The patient was diagnosed with acanthosis nigricans and hypertrichosis at birth,and the growth rate was slower than that of normal children.At age 5,the patient had severe hyperinsulinemia,congenital heart abnormalities,and pineal cysts.At age 13,he was diagnosed with diabetes and exhibited symptoms of hyperinsulinemia,low body weight,growth retardation,acanthosis nigricans,dental anomalies,an oversized penis,and a pineal cyst.Sequencing results indicated an INSR c.1123+2 T>C mutation,and bioinformatic analysis suggested that this mutation led to splicing abnormalities,thereby affecting INSR function.Both parents carried the mutated gene,whereas his brother had a normal genotype.CONCLUSION Genetic diagnosis is vital in RMS;c.1123+2 T>C mutation of INSR causes pancreatic decline;current treatments show limited effectiveness. 展开更多
关键词 Rabson-Mendenhall syndrome Insulin receptor gene Splice mutation Hyperinsulinemia Case report
暂未订购 下载PDF
Lipid-related Insulin Resistance Indices for the Diagnosis of Non-alcoholic Fatty Liver Disease in Chinese Adults 认领 引用 被引量：1
8
作者 Weihua Cao Yaqin Zhang +15 位作者 Ziyu Zhang Xinxin Li Wen Deng Shiyu Wang Xin Wei Linmei Yao Zixuan Gao Shuojie Wang Lu Zhang Yao Lu Ruyu Liu Shuling Wu Yuanjiao Gao Hongxiao Hao Yao Xie Minghui Li 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期171-182,共12页
Objective To analyze the diagnostic efficacy of lipid-related insulin resistance(IR)markers in patients with non-alcoholic fatty liver disease(NAFLD)and metabolic abnormalities(MA).Method Patients with NAFLD with MA,n... Objective To analyze the diagnostic efficacy of lipid-related insulin resistance(IR)markers in patients with non-alcoholic fatty liver disease(NAFLD)and metabolic abnormalities(MA).Method Patients with NAFLD with MA,non-NAFLD patients with MA,and patients with NAFLD without MA underwent liver biopsy.Homeostasis model assessment of insulin resistance(HOMA-IR),triglyceride/high-density lipoprotein cholesterol(TG/HDL-C),visceral obesity index(VAI),lipid accumulation product(LAP),and triglyceride glucose(TyG)index were analyzed.The diagnostic efficacy of these indicators of NAFLD was also evaluated.Results In the NAFLD-MA group,BMI,HOMA-IR,LAP,VAI,TyG index,and TG/HDL-C ratio were higher than those in the non-NAFLD-MA group(P<0.001).Logistic regression indicated that BMI and TyG index were independent risk factors for NAFLD.Receiver Operating Characteristic(ROC)curves analysis revealed that the Area Under the ROC Curve(AUC)for TyG-BMI was 0.819,and the optimal cutoff for NAFLD was TyG-BMI 39.77.For patients with NAFLD with or without MA,logistic regression analysis suggested that age,TG level,and TyG index were independent risk factors.The area under the ROC curve showed that AUC for the TyG index was 0.724.The optimal cutoff for NAFLD-non MA was a TyG index of 1.580.Conclusion TyG index has diagnostic value in both types of NAFLD;however,TyG-BMI is better in patients with NAFLD with MA and may be an effective screening indicator alone in patients with NAFLD without MA. 展开更多
关键词 Lipid-related insulin resistance marker Nonalcoholic fatty liver disease Triglyceride glucose index Metabolic abnormalities
暂未订购 下载PDF
Metabolic breakdown:Linking insulin resistance and mitochondrial dysfunction to neurodegeneration in Alzheimer’s disease 认领 引用
9
作者 Simona Lanzillotta Lucrezia Romana Rolfi +1 位作者 Barbara Zulli Eugenio Barone 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2227-2237,共11页
The increasing prevalence of metabolic disorders and neurodegenerative diseases has uncovered shared pathophysiological pathways,with insulin resistance and mitochondrial dysfunction emerging as critical contributors ... The increasing prevalence of metabolic disorders and neurodegenerative diseases has uncovered shared pathophysiological pathways,with insulin resistance and mitochondrial dysfunction emerging as critical contributors to cognitive decline.Insulin resistance impairs neuronal metabolism and synaptic function,fostering neurodegeneration as observed in Alzheimer’s disease and Down syndrome.Indeed,Down syndrome,characterized by the triplication of the APP gene,represents a valuable genetic model for studying early-onset Alzheimer’s disease and accelerated aging.Building on the link between metabolic dysfunctions and neurodegeneration,innovative strategies addressed brain insulin resistance as a key driver of cognitive decline.Intranasal insulin has shown promise in improving cognition in early Alzheimer’s disease and type 2 diabetes,supporting the concept that restoring insulin sensitivity can mitigate neurodegeneration.However,insulin-based therapies risk desensitizing insulin signaling,potentially worsening the disease.Incretins,particularly glucagon-like peptide 1 receptor agonists,offer neuroprotective benefits by enhancing insulin sensitivity,metabolism,and synaptic plasticity while reducing oxidative distress and neuroinflammation.This review focuses on current knowledge on the metabolic and molecular interactions between insulin resistance,mitochondrial dynamics(including their roles in energy metabolism),and oxidative distress regulation,as these are pivotal in both Alzheimer’s disease and Down syndrome.By addressing these interconnected mechanisms,innovative treatments may emerge for both metabolic and neurodegenerative disorders. 展开更多
关键词 aging Alzheimer’s disease brain insulin resistance Down syndrome energy metabolism glucagon-like peptide 1 incretins insulin mitochondria neurodegeneration
暂未订购 下载PDF
From lipodystrophy to subcutaneous insulin depots:Overlooked mechanisms of glycemic variability in patients with diabetes 认领 引用
10
作者 Nhi Thi Y Nguyen Hau Phuc Tran +5 位作者 Dat Xuan Nguyen Duong Hung Tran Phuong Ho Thi Hoai Thang Viet Luong Hai Nguyen Ngoc Dang Meng-Chi Lee 《World Journal of Diabetes》 SCIE 2026年第5期86-94,共9页
Lipohypertrophy(LH)is the most common complication of insulin injection therapy but remains underrecognized in routine care.Repeated injections into the same area promote subcutaneous fat hypertrophy and fibrosis,whic... Lipohypertrophy(LH)is the most common complication of insulin injection therapy but remains underrecognized in routine care.Repeated injections into the same area promote subcutaneous fat hypertrophy and fibrosis,which can create insulin depot behavior and lead to delayed,blunted,and highly variable insulin absorption.As a result,patients may develop unexplained glycemic instability,including persistent postprandial hyperglycemia and late,unpredictable hypoglycemia that complicates insulin titration.Clinical inspection and palpation detect only a proportion of lesions,whereas high-frequency ultrasound can improve detection and lesion mapping,particularly when lesions are subtle or deep.This review synthesizes current evidence linking injection-site tissue remodeling to altered insulin pharmacokinetics and clinically meaningful glycemic variability and provides a practical pathway for diagnosis and management.Key elements include systematic injection-site assessment,structured technique education with site rotation,and intensified glucose monitoring with individualized dose adjustment when injections are switched away from the LH,as absorption may become faster and more predictable.Recognizing LH as a modifiable driver of insulin depot-related variability shifts clinical focus from repeated dose escalation to correcting injection-site factors,thereby improving the safety and effectiveness of insulin therapy. 展开更多
关键词 Insulin depot Lipohypertrophy Lipodystrophy Insulin absorption Injection technique Ultrasound Diabetes
暂未订购 下载PDF
Peanut skin procyanidins regulate insulin signaling and hepatic metabolism in diabetic mice 认领 引用
11
作者 Min Liu Huifang Zhang +5 位作者 Tingting Ju Benjamin P.Willing Wanbing Chen Jun Liu Qun Lu Rui Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期879-891,共13页
Diabetes is accompanied by oxidative damage,inflammation,and disorder of metabolic profiles.Dietary procyanidins have been reported to alleviate symptoms of diabetes,however,the underlying mechanism through which proc... Diabetes is accompanied by oxidative damage,inflammation,and disorder of metabolic profiles.Dietary procyanidins have been reported to alleviate symptoms of diabetes,however,the underlying mechanism through which procyanidins impact liver metabolic function remains unclear.Here,the effects of p eanut skin procyanidins(PSP)on oxidative stress,inflammatory injury,and dysregulated metabolism in the liver of diabetic mice were evaluated.The results showed that PSP r educed the accumulation of cholesterol and alleviated oxidative stress and inflammatory response in the liver.Moreover,PSP enhanced i nsulin signaling by increasing hepatic protein expression of insulin receptor substrate 1/phosphatidylinositol-3-kinase/protein kinase B.Untargeted metabolomics revealed that PSP altered bile acid biosynthesis,alpha linolenic acid and linoleic acid,arachidonic acid,and glycolipid metabolism in the liver.This study reveals positive effects of PSP in alleviating liver dysfunction in diabetic mice. 展开更多
关键词 Peanut skin procyanidins Insulin signaling Infl ammatory response Hepatic metabolism
暂未订购 下载PDF
Neurodegenerative processes of aging: A perspective of restoration through insulin-like growth factor-1 认领 引用
12
作者 Rosana Crespo Claudia Herenu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1562-1563,共2页
The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurode... The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurodegenerative diseases are characterized by the progressive loss of neuronal structure and function. 展开更多
关键词 neurodegenerative diseases neurodegenerative processes cognitive impairments progressive loss neuronal structure function develo ping neurological dysfunctions insulin growth factor restoration aging process
暂未订购 下载PDF
Ultrasound hepatic elastography:A non-invasive indicator of insulin resistance in the pediatric population:A systematic review 认领 引用
13
作者 Reem M Elbeltagi Nermin K Saeed +1 位作者 Adel S Bediwy Mohammed Al-Beltagi 《World Journal of Clinical Pediatrics》 2026年第2期353-368,共16页
BACKGROUND Insulin resistance(IR)plays a pivotal role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.While non-invasive imaging methods are increasingly used in pediatrics,the extent t... BACKGROUND Insulin resistance(IR)plays a pivotal role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.While non-invasive imaging methods are increasingly used in pediatrics,the extent to which hepatic elastography reflects IR in children remains unclear.AIM To evaluate the association between ultrasound-based hepatic elastography parameters and clinical indices of IR in the pediatric population.METHODS A systematic search of PubMed,Scopus,and Web of Science databases was conducted through October 2025.Studies assessing correlations between elastography parameters-controlled attenuation parameter(CAP)and liver stiffness measurement(LSM)-and IR indices were included.Data were pooled using random-effects meta-analysis with correlation coefficients(r)as the primary effect size.Subgroup and sensitivity analyses examined differences by IR index,cohort characteristics,and elastography modality.RESULTS Sixteen studies,encompassing 2,032 children and adolescents,were included.The pooled correlation between hepatic elastography(CAP/LSM)and IR indices was r=0.44(95%confidence interval:0.38-0.50;I2=72%),indicating a moderate positive association.The strongest correlations were observed for adipose tissue IR(r=0.65)and the metabolic score for IR(r=0.49),surpassing simpler indices such as homeostatic model assessment of IR.CAP correlated moderately with early steatosis(r=0.30-0.40),whereas LSM showed stronger associations with advanced fibrosis and systemic IR(r=0.50-0.65).Heterogeneity was mainly attributed to differences in disease severity and measurement methods.CONCLUSION Ultrasound-based hepatic elastography provides a reliable,non-invasive surrogate for systemic metabolic dysfunction in pediatric metabolic dysfunction-associated steatotic liver disease.CAP reflects early,reversible hepatic fat accumulation,while LSM reflects more advanced fibrosis and systemic IR,and identifies fibrotic progression driven by chronic IR.The strongest associations with adipose tissue-IR and metabolic score-IR highlight the systemic,multisite nature of pediatric IR.Elastography thus holds promise as an integrated biomarker for IR severity,early risk stratification,and therapeutic monitoring in children and adolescents with metabolic risk factors. 展开更多
关键词 Pediatric metabolic dysfunction-associated steatotic liver disease Insulin resistance Liver stiffness measurement Controlled attenuation parameter Transient elastography Metabolic syndrome Non-invasive biomarkers
暂未订购 下载PDF
Association of Helicobacter pylori infection with insulin resistance,tumor necrosis factor-alpha,and dyslipidemia in obese children with metabolic syndrome 认领 引用
14
作者 Noura M Ibrahim Elbakry Mohamed S Hemeda +9 位作者 Ayat Mostafa Mohamed Ahmed Hager Adel Zaky Aya Nabil Gamil Abd Elmoaty Arafat Abd Elmoaty Mahmoud M Khafagi Ashraf Mohamed Alkabeer Aldosoky Abd Elaziz Alsaid Ahmed A Elhagary Walid Mohammed Aboassy Ahmed Nabil Gamil Mohammed 《World Journal of Clinical Pediatrics》 2026年第3期279-291,共13页
BACKGROUND Previous studies have suggested a link between Helicobacter pylori(H.pylori)and metabolic complications outside the gastrointestinal tract,but the relationship with pediatric obesity remains unclear.We aim ... BACKGROUND Previous studies have suggested a link between Helicobacter pylori(H.pylori)and metabolic complications outside the gastrointestinal tract,but the relationship with pediatric obesity remains unclear.We aim to study the correlation between H.pylori infection and components of insulin resistance(IR),inflammation[tumor necrosis factor-alpha(TNF-α)],and cardiometabolic parameters in obese children/adolescents with a metabolic syndrome(MetS)phenotype.AIM To elucidate the association between H.pylori infection and metabolic disturbances in children with obesity and MetS,focusing on homeostasis model assessment of IR(HOMA-IR),inflammatory markers(TNF-α),and the lipid profile.METHODS The study recruited 70 obese children/adolescents with MetS phenotype from the pediatric units of Minia University Hospital from September 2023 to October 2024.H.pylori stool antigen quantitative enzyme-linked immunosorbent assay was used to classify participants into H.pylori-negative(n=35)and H.pylori-positive(n=35).Assessment of fasting glucose,glycated hemoglobin(HbA1c),fasting insulin,lipid profile,liver enzymes,TNF-α,adiponectin,and leptin,as well as other parameters,was done.IR was calculated in detail using the HOMA-IR formula(fasting insulin×fasting glucose/405).Various statistical analyses,including intergroup comparisons,correlation analyses,and receiver operating characteristic curve analyses,were also performed.RESULTS Groups were similar in age,sex,and standardized body mass index(BMI)value.Elevated blood pressure(65.7%vs 31.4%,P=0.004)and hepatomegaly(62.9%vs 28.6%,P=0.004)were more common in H.pylori-positive participants.The infected group had higher alanine aminotransferase and aspartate aminotransferase(AST)levels(both P1.67 had excellent sensitivity and specificity for detecting H.pylori positivity[area under the curve(AUC):0.954;sensitivity 88.6%,specificity 97.1%],and TNF-αhad moderate sen-sitivity(AUC:0.677).CONCLUSION H.pylori positivity was linked to elevated IR,TNF-α,atherogenic dyslipidemia,and a greater hepatic/clinical metabolic burden in the MetS phenotype of obesity in children and adolescents.More longitudinal studies that will help control socioeconomic and lifestyle confounding are warranted. 展开更多
关键词 Helicobacter pylori Childhood obesity Metabolic syndrome phenotype Insulin resistance Homeostasis model assessment of insulin resistance Tumor necrosis factor-alpha Dyslipidemia
暂未订购 下载PDF
Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance 认领 引用 被引量：1
15
作者 Oscar E Casillas César A Hernández-Aguirre +2 位作者 Ana Gabriela Leija-Montoya J Gustavo Vázquez-Jiménez Tatiana Romero-García 《World Journal of Diabetes》 SCIE 2026年第5期169-177,共9页
BACKGROUND In our search to unravel the pathophysiological mechanisms underlying the development of insulin resistance(IR)in the young population,we evaluated the waist-to-height ratio(WtHR)in 39 participants,setting ... BACKGROUND In our search to unravel the pathophysiological mechanisms underlying the development of insulin resistance(IR)in the young population,we evaluated the waist-to-height ratio(WtHR)in 39 participants,setting 0.5 as the cut-off value.A high WtHR has been associated with metabolic alterations and increased risk of developing IR.AIM To explore the relationship between WtHR and IR in young individuals with endoplasmic reticulum(ER)stress molecular mechanisms.METHODS This was a cross-sectional study conducted at the Faculty of Medicine of the Autonomous University of Baja California(Mexico).A total of 39 young participants(18-25 years old,both sexes)were recruited from the general community.All measurements and sample analyses were performed in a single study visit per participant.According to their WtHR,0.5 is used as the threshold to define high or low WtHR.The degree of IR was estimated using the Homeostatic Model Assessment of Insulin Resistance(HOMA-IR)index.Additionally,we analyzed ER stress markers in platelets,including SERCA protein expression and phosphorylation levels of PERK and JNK.Data were analyzed using one-way ANOVA followed by Dunn’s post-hoc test.RESULTS Young individuals with high WtHR showed greater body weight,body mass index,and visceral fat area percentage;additionally,high-density lipoprotein cholesterol(HDL-C)levels were lower,and the triglyceride/HDL-C ratio was higher(P<0.05).Fasting insulin was higher in the high-WtHR group(18.76±2.35μU/mL vs 13.54±1.5μU/mL;P<0.05),resulting in elevated HOMA-IR(4.34±0.54 vs 2.90±0.3;P<0.05).Moreover,platelets from participants with high WtHR exhibited elevated SERCA protein expression(297.3±39.4 vs 98.8±14.9;P<0.0002)and increased PERK phosphorylation(532.0±98.9 vs 127.8±29.6;P<0.001),indicating activation of the unfolded protein response.These platelets also showed greater JNK phosphorylation than those from individuals with low WtHR(604.9±216.3 vs 126.7±25;P<0.04),confirming JNK activation,a negative regulator of the insulin signaling pathway.CONCLUSION High-WtHR in young people is associated with IR and ER stress,driven by JNK activation in platelets,suggesting molecular alterations in early metabolic dysfunction. 展开更多
关键词 Endoplasmic reticulum stress Insulin resistance Waist-to-height ratio Unfolded protein response Adiposity
暂未订购 下载PDF
Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance 认领 引用 被引量：2
16
作者 Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第11期3113-3123,共11页
Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close rel... Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms.Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological processes.The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed. 展开更多
关键词 brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling neurodegeneration Parkinson's disease targeted therapy
暂未订购 下载PDF
Isoleucine and valine regulate the BCAA antagonism by influencing insulin function in broiler chickens 认领 引用
17
作者 Bin Wang Xiaodan Zhang +4 位作者 Guang Li Mingkun Gao Yuqing Feng Yong He Yuming Guo 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期867-882,共16页
Background The phenomenon where excessive activation of branched-chain amino acid(BCAA)degrading enzymes caused by high concentrations of leucine(Leu)leads to a decrease in the overall concentration of BCAA[including ... Background The phenomenon where excessive activation of branched-chain amino acid(BCAA)degrading enzymes caused by high concentrations of leucine(Leu)leads to a decrease in the overall concentration of BCAA[including isoleucine(Ile)and valine(Val)]is called BCAA antagonism.Although this phenomenon has long been widely studied,the specific mechanism of its occurrence is still poorly understood.In this study,we investigated the specific mechanism by which Val and Ile alleviate the antagonistic effect caused by high concentrations of Leu through influencing insulin function.First,the ratios of Ile and Val in the low-protein diet were adjusted up and down by 15%to observe the metabolic status of broilers at the end of the experiment(the experiment period was from 0 to 42 d).Subsequently,the physiological and biochemical changes related to antagonism were determined using transcriptome and lipid metabolome analyses.Results When fed with a high concentration of Leu,restricting Ile or supplementing Val can effectively alleviate antagonism.Under conditions of excessive dietary Val supplementation,insulin levels remained stable,whereas blood glucose levels increased(P<0.05),and liver fat accumulated predominantly as ceramides rather than triglycerides,thereby disrupting the insulin-mediated phosphatidylinositol 3-kinase/protein kinase B signaling pathway(P<0.05).Excessive dietary Ile promoted liver inflammation and interleukin-6 release(P<0.05),which acted on the pancreas to enhance insulin secretion.Additionally,the glucagon content in the pancreas decreased(P<0.05),while insulin and glucagon-like peptide-1 levels increased(P<0.05).Conclusion Supplementation of Val or restriction of Ile in low-protein diets could alleviate the BCAA antagonism caused by high Leu,which mainly achieved by influencing insulin function.These findings provide new insights in revealing the BCAA antagonism. 展开更多
关键词 Antagonism Branched-chain amino acids Broiler chicken Inflammatory factors Insulin
暂未订购 下载PDF
Fat deposition and growth performance in broiler chickens are diversely influenced by maize or wheat following dietary crude protein reductions plausibly involving insulin 认领 引用
18
作者 Mengzhu Wang Shemil P.Macelline +1 位作者 Sonia Yun Liu Peter H.Selle 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期675-695,共21页
There is increasing interest in developing reduced-crude protein(CP)diets for broiler chickens because their commercial adoption would generate a diverse range of advantages that would enhance the sustainability of th... There is increasing interest in developing reduced-crude protein(CP)diets for broiler chickens because their commercial adoption would generate a diverse range of advantages that would enhance the sustainability of the chickenmeat industry.However,the development of reduced-CP broiler diets is proving to be not straightforward,particularly when dietary CP reductions exceed 30 g/kg.The capacity of broilers to accommodate dietary CP reductions when offered maize-based diets is superior to their counterparts offered wheat-based diets.Numerous factors could be contributing to this difference but have yet to be identified with certainty.Maize-based,reduced-CP diets characteristically support better weight gains and efficiencies of feed conversion than wheat-based diets,but this better growth performance is associated with increased fat deposition,monitored as heavier relative abdominal fat-pad weights.This is an intriguing dichotomy.Insulin is a powerful anabolic hormone in mammalian species capable of promoting fat deposition,protein accretion and growth,but the importance of insulin in avian species is usually dismissed.This is because broiler chickens are considered both hyperglycaemic and resistant to insulin.However,the likelihood is that young broiler chickens are more sensitive to insulin than is generally recognised and the anabolic properties of insulin may be contributing to the diverse responses observed between maize and wheat in the context of reduced-CP diets.Dietary CP reductions may trigger increased plasma ammonia concentrations and metabolic acidosis,but both factors can influence insulin secretion and insulin resistance.Maize has slower rates of starch digestion and glucose absorption than wheat and it has been suggested that this generates a more sustained insulin release resulting in increased weight gains and fat deposition.If so,this could be driving the differences generated by the feed grain selected as the basis of reduced-CP diets.The intention of this review is to explore this proposition because if the causal factors of the differences between maize and wheat can be identified the development and acceptance of reduced-CP broiler diets should be accelerated. 展开更多
关键词 Amino acids Broiler chickens Crude protein Fat Glucose Insulin Maize Starch Wheat
暂未订购 下载PDF
Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease 认领 引用
19
作者 Qing-Tao Yu Yun-Ying Lin +7 位作者 Zi-Hao Gui Hua-Lin Duan Jun-Jie Yang Yuan Meng Xue-Tao Peng Lan Liu Heng Wan Jie Shen 《World Journal of Gastroenterology》 SCIE CAS 2026年第21期76-88,共13页
BACKGROUND Suboptimal sleep quality is increasingly recognized as a potential modifiable risk factor for metabolic dysfunction-associated steatotic liver disease(MASLD).However,epidemiological evidence remains limited... BACKGROUND Suboptimal sleep quality is increasingly recognized as a potential modifiable risk factor for metabolic dysfunction-associated steatotic liver disease(MASLD).However,epidemiological evidence remains limited and inconsistent.Importantly,the underlying biological mechanisms,particularly the potential mediating pathways linking sleep to MASLD pathogenesis,are still poorly understood.To investigate the relationship between sleep quality and MASLD prevalence,along with its potential mechanisms,in a community-based Chinese population.METHODS A total of 7871 adults were enrolled from 10 communities in Foshan,Guangdong Province,China.Sleep health status over the preceding month was assessed using the healthy sleep scores(HSS).The associations between HSS and MASLD were analyzed using multivariable logistic regression models.Mediation analyses were conducted to quantify the mediating effects of homeostasis model assessment of insulin resistance(HOMA-IR),remnant cholesterol(RC),non-high-density lipoprotein cholesterol(non-HDL-C),and high-sensitivity C-reactive protein(hs-CRP)on the relationship between HSS and MASLD.RESULTS Participants with an optimal HSS of 5 exhibited a significantly reduced prevalence of MASLD compared to those with an HSS of 0-2,corresponding to a 35.5%reduction in risk(OR=0.65;95%CI:0.52-0.80,P<0.001).Among the five components of the HSSs,the absence of sleep apnea was most strongly associated with a decreased risk of MASLD,indicating a 31.8%reduction in risk(OR=0.68;95%CI:0.47-0.98,P=0.040).Mediation analyses revealed that the relationship between HSS and MASLD was partially mediated by HOMA-IR(mediation proportion 23.2%),hs-CRP(9.7%),RC(5.3%),and non-HDL-C(6.1%).CONCLUSION Higher HSS scores were associated with lower prevalence of MASLD,with HOMA-IR,hs-CRP,RC,and non-HDLC serving as partial mediators of this association. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Healthy sleep score Mediator Homeostasis model assessment of insulin resistance High-sensitivity C-reactive protein
暂未订购 下载PDF
Dysregulated insulin signaling and inflammation contribute to the pathogenesis of Alzheimer’s disease:From animal models to human cells 认领 引用
20
作者 Marcus Elo Rytter Cecilie Amalie Brøgger Svane +1 位作者 Joachim Størling Wenqiang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1126-1127,共2页
The shared links between Alzheimer’s disease and type 2 diabetes mellitus:Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two prevalent conditions that come with substantial daily struggles.Emerging evi... The shared links between Alzheimer’s disease and type 2 diabetes mellitus:Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two prevalent conditions that come with substantial daily struggles.Emerging evidence highlights that these diseases share similar pathophysiological features,including insulin resistance and chronic inflammation,which contribute to their rapid progression(Chen et al.,2022).Insulin resistance,a hallmark of T2DM,has been suggested to exacerbate neurodegeneration in AD.Similarly,chronic low-grade inflammation in T2DM parallels with neuroinflammation,which is observed in AD,suggesting overlapping pathophysiological mechanisms in T2DM and AD. 展开更多
关键词 alzheimer s disease chronic inflammationwhich type diabetes mellitus alzheimer s disease ad inflammation exacerbate neurodegeneration Alzheimers disease insulin resistance type diabetes mellitus t dm
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 250 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈