Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnec...Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.展开更多
Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Red...Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.In all phases of disaster risk management including forecasting,emergency response and post-disaster reconstruction,the need for interconnected multidisciplinary open data for collaborative reporting as well as study and analysis are apparent,in order to determine disaster impact data in timely and reportable manner.The extraordinary progress in computing and information technology in the past decade,such as broad local and wide-area network connectivity(e.g.Internet),highperformance computing,service and cloud computing,big data methods and mobile devices,provides the technical foundation for connecting open data to support disaster risk research.A new generation of disaster data infrastructure based on interconnected open data is evolving rapidly.There are two levels in the conceptual model of Linked Open Data for Global Disaster Risk Research(LODGD)Working Group of the Committee on Data for Science and Technology(CODATA),which is the Committee on Data of the International Council for Science(ICSU):data characterization and data connection.In data characterization,the knowledge about disaster taxonomy and data dependency on disaster events requires specific scientific study as it aims to understand and present the correlation between specific disaster events and scientific data through the integration of literature analysis and semantic knowledge discovery.Data connection concepts deal with technical methods to connect distributed data resources identified by data characterization of disaster type.In the science community,interconnected open data for disaster risk impact assessment are beginning to influence how disaster data are shared,and this will need to extend data coverage and provide better ways of utilizing data across domains where innovation and integration are now necessarily needed.展开更多
Porous hydroxyapatite (HA)-tricalcium phosphate (TCP) ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates (DCPD) were added at various ra...Porous hydroxyapatite (HA)-tricalcium phosphate (TCP) ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates (DCPD) were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity (- 85%) was observed in the Ca-P scaffold with the lowest HA (-7%) content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content ( - 85%). X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.展开更多
The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they ...The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.展开更多
The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic...The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.展开更多
We demonstrate a fully integrated eight-channel dense wavelength-division multiplexing silicon photonic transceiver supporting 200-Gbps per-channel PAM4 operation,enabling a total chip-to-chip data rate of 1.6 Tbps.Th...We demonstrate a fully integrated eight-channel dense wavelength-division multiplexing silicon photonic transceiver supporting 200-Gbps per-channel PAM4 operation,enabling a total chip-to-chip data rate of 1.6 Tbps.The transmitter employs compact single-bus microring modulators,whereas the receiver adopts a polarization diversity architecture based on cascaded dual-ring filters and integrates a bidirectionally incident photodetector,maintaining stable performance under arbitrary input polarization.A unified multichannel thermo-optic feedback architecture is implemented at both the transmitter and receiver,enabling cooperative link-level wavelength alignment without pre-calibration.This multi-channel parallel control scheme reduces wavelength locking time by~30×while achieving fine wavelength-tracking accuracy of 2.74 pm with negligible thermal overhead.Comprehensive device-and system-level experiments validate the robustness and scalability of the proposed architecture.We uniquely address the critical bottlenecks of high polarization sensitivity and latency in wavelength alignment through a highly integrated silicon photonic architecture.By implementing polarization-splitting grating couplers and synchronized wavelengthlocking schemes,we provide a transformative solution for high-density co-packaged optics.Our approach significantly reduces system footprint,enhances operational reliability,and improves power efficiency,thereby bridging the gap between laboratory demonstrations and practical 1.6-Tbps scale chip-to-chip interconnects.展开更多
The IUGG Associations for Atmosphere,Oceans and Cryosphere—IAMAS,IAPSO and IACS—held a Joint Scientific Assembly in Busan,South Korea,from 20 to 25 July 2025.This was the first joint assembly of all three associatio...The IUGG Associations for Atmosphere,Oceans and Cryosphere—IAMAS,IAPSO and IACS—held a Joint Scientific Assembly in Busan,South Korea,from 20 to 25 July 2025.This was the first joint assembly of all three associations since 2009,when they met in Montreal,Canada.It was the first time any of the associations had been hosted in Korea,and it had been two decades since any of them had met in Asia.The choice of Busan as the venue supported high levels of participation and smooth conference operations.The Local Organizing Committee,chaired by Prof.Kyung-Ja Ha of Pusan National University,oversaw the successful organization of the event.The assembly brought together 1725 participants in total,including 1282 researchers and 443 invited participants and individuals involved in side events,exhibitions,media coverage,and volunteer work.Participants came from 46 countries across Asia,Europe,North America,South America,Africa,and Oceania.IAMAS had 736 participants,IAPSO 321,and IACS 225.Survey data from 951 respondents revealed that Early Career Scientists,defined as those within 10 years of receiving their PhD,accounted for approximately 25%of participants.The demographic profile skewed young,with 66%of attendees in their 20s and 30s.The scientific program was organized by Prof.Seon-Ki Park(Chair),the Secretaries General from all three Associations,and the Local Organizing Committee.Reflecting the theme“Our Interconnected Earth,”the scientific program emphasized integrated approaches to climate systems,addressing climate change and environmental challenges through collaborative,transdisciplinary research.展开更多
The development of lightweight,high‐attenuation,and broadband carbon‐based electromagnetic wave absorbers is hindered by the intrinsic trade‐off between impedance matching and dielectric dissipation.Herein,we repor...The development of lightweight,high‐attenuation,and broadband carbon‐based electromagnetic wave absorbers is hindered by the intrinsic trade‐off between impedance matching and dielectric dissipation.Herein,we report a facile and scalable synthesis of N‐doped lignin‐derived interconnected porous carbon(Nx‐LIPC)via hydrogen‐bond self‐assembly and subsequent pyrolysis.The synergistic integration of the interconnected porous architecture with multi‐configurational N doping substantially boosts the absorption performance.At an exceptionally low filler loading of 3 wt%,the optimized N0.5‐LIPC achieves a minimum reflection loss of−48.07 dB with a thin matching thickness of 1.9 mm.This performance represents a 350%and 130%enhancement in attenuation intensity compared with the counterparts with only nitrogen doping(N0.5‐LC)or only structural regulation(N0‐LIPC),respectively.Furthermore,N0.5‐LIPC exhibits a broad effective absorption bandwidth of 6.17 GHz at a thickness of 1.7 mm.Mechanistic studies reveal that the three‐dimensional(3D)interconnected network not only facilitates multiple internal reflections and optimizes impedance matching but also strengthens conductive and interfacial polarization losses.Critically,density functional theory calculations corroborate that N incorporation,particularly pyrrolic and pyridinic N,generates strong localized dipoles,introducing additional dipolar polarization loss.This work offers an innovative and sustainable strategy for fabricating high‐performance carbon‐based absorbers from biomass resources.展开更多
The existing studies on spacecraft focus on improving the networked,intelligent,and autonomous level of avionics systems.This paper reviews the research status of spacecraft avionics system architecture and typical sp...The existing studies on spacecraft focus on improving the networked,intelligent,and autonomous level of avionics systems.This paper reviews the research status of spacecraft avionics system architecture and typical spacecraft avionics system,as well as the technical features and potential trends of key technologies,such as network interconnection,high-speed bus,onboard computing,autonomous operation,and software-defined technology.A development roadmap,a novel kind of intelligent system architecture and application scenarios of avionics systems are then proposed.To tackle the challenges faced in the development of spacecraft avionics systems,suggestions are made from the aspects of system architecture,heterogeneous network interconnection,on-orbit intelligent information processing,Commercial Off-The-Shelf(COTS)products application,and intelligent autonomous management.This provides a guide for the related studies on the development of spacecraft avionics technology.展开更多
The advent of artificial intelligence,cloud services,and big data applications has propelled the evolution of next-generation high-capacity datacenters.It is highly anticipated that coherent detection will penetrate f...The advent of artificial intelligence,cloud services,and big data applications has propelled the evolution of next-generation high-capacity datacenters.It is highly anticipated that coherent detection will penetrate further into datacenters in the next decade.However,the large number of tunable lasers in data centers makes the optical module structure complex and adds additional thermal power consumption.Meanwhile,optical frequency combs serve as high-precision frequency resolution and wide spectral coverage lasers,holding tremendous potential for the field of wavelength division multiplexing optical communication.Here,we present an innovative global frequency-synchronous optical network(globalFSON)architecture for coherent short-reach optical interconnects by synchronizing optical frequency combs to a global positioning system disciplined oscillator(GPSDO)and distributing them.The globalFSON architecture can share GPS-referenced optical frequency combs as master lasers among different servers,which eliminates the need for a massive number of tunable lasers in datacenter optical interconnects.On this basis,we achieve a reset-free carrier phase recovery analog coherent receiver in the optical domain and demonstrate dual-polarization coherent signals demultiplexing without coherent silicon applicationspecific integrated circuits.We introduce the global-FSON architecture that provides a laser source with absolute stability for all transponders in datacenter coherent optical interconnects.Its implementation would bolster the potential applicability of coherent optical communication in next-generation datacenter coherent optical interconnects.展开更多
Load frequency control(LFC)in interconnected power systems has always been a challenging task in the presence of uncertainty and variability in the power systems arising primarily due to the integration of renewable e...Load frequency control(LFC)in interconnected power systems has always been a challenging task in the presence of uncertainty and variability in the power systems arising primarily due to the integration of renewable energy sources and the impact of electric vehicles on the power system.Although various PI/PID and other advanced control strategies have been employed for LFC in power systems,the existing methods have shown some limitations in terms of dynamic flexibility and robustness in the presence of nonlinearities and couplings in the power systems.Moreover,the optimization methods employed for the tuning of the controllers have shown some limitations in terms of the balance between global and local search abilities of the optimization functions.To overcome the limitations of the existing methods and optimization functions,a hybrid Modified Zebra Optimization Algorithm-Particle Swarm Optimization(MZOA-PSO)is presented in this paper for the optimization of a cascaded PI(1+DD)-PI-PID controller for LFC in power systems.The MZOA enhances the original ZOA by chaotic initialization,adaptive parameter control,and Lévy-flight foraging to improve the global search ability,while PSO ensures efficient local search ability.The optimizer is first validated using four benchmark functions,achieving the global optimum for the Booth and Zakharov functions,a mean value of 2.13×10−28 with a 98%success rate for Rosenbrock,and 3.21×10−81 for Schwefel 2.22.Under a 1%step load perturbation,the proposed controller achieves a 13 s settling time,zero negative deviation in Area 2,a maximum positive excursion of 0.10 Hz,and tie-line undershoot limited to−0.10 p.u.Under random load variations,deviations remain within±0.03 Hz and±0.02 p.u.Under RES and EV integration,the peak frequency deviation is reduced to 0.46 Hz in Area 1.These results confirm that the proposed hybrid MZOA-PSO tuned cascaded controller provides improved damping,faster stabilization,and stronger robustness for modern interconnected LFC systems.展开更多
To investigate transient flow instabilities in parallel-channel regenerative cooling systems subjected to nonuniform heat flux,a three-dimensional transient numerical model was developed to couple variations in superc...To investigate transient flow instabilities in parallel-channel regenerative cooling systems subjected to nonuniform heat flux,a three-dimensional transient numerical model was developed to couple variations in supercritical fluid thermophysical properties with endothermic pyrolysis kinetics.The spatiotemporal evolution of RP-3 fuel within parallel channels was analyzed,and the role of a midstream interconnection structure in mitigating flow maldistribution was clarified.During the initial heating stage,the viscosity reduction of the supercritical fuel produced a drag-reduction effect that temporarily maintained a nearly uniform flow distribution.As the wall temperature increased and the pseudocritical region approached,the sharp decrease in density markedly increased the acceleration pressure drop,disrupting the pressure balance between channels.In combination with the progressive accumulation of pyrolysis products,this process led to a positive feedback loop characterized by flow rate reduction,insufficient heat absorption,and increasing flow resistance.The introduction of a midstream interconnection enabled pressure-driven lateral mass transfer between channels.The resulting crossflow was directed predominantly from the high-heat-flux channel toward the low-heat-flux channel,providing a release path for overheated,low-density,and strongly cracked fluid in the high-heat-flux channel and thereby weakening the downstream accumulation of thermal and compositional nonuniformities as well as the associated resistance amplification.Compared with the configuration without interconnection,the stage-averaged maximum flow-deviation coefficient decreased by 17.4%during the pseudocritical transition stage and by 48.3%during the deep-pyrolysis stage.展开更多
This paper presents an optimal operation method for embedded DC interconnections based on low-voltage AC/DC distribution areas(EDC-LVDA)under three-phase unbalanced compensation conditions.It can optimally determine t...This paper presents an optimal operation method for embedded DC interconnections based on low-voltage AC/DC distribution areas(EDC-LVDA)under three-phase unbalanced compensation conditions.It can optimally determine the transmission power of the DC and AC paths to simultaneously improve voltage quality and reduce losses.First,considering the embedded interconnected,unbalanced power structure of the distribution area,a power flow calculation method for EDC-LVDA that accounts for three-phase unbalanced compensation is introduced.This method accurately describes the power flow distribution characteristics under both AC and DC power allocation scenarios.Second,an optimization scheduling model for EDC-LVDA under three-phase unbalanced conditions is developed,incorporating network losses,voltage quality,DC link losses,and unbalance levels.The proposed model employs an improved particle swarm optimization(IPSO)two-layer algorithm to autonomously select different power allocation coefficients for the DC link and AC section under various operating conditions.This enables embedded economic optimization scheduling while maintaining compensation for unbalanced conditions.Finally,a case study based on the IEEE 13-node system for EDC-LVDA is conducted and tested.The results show that the proposed optimal operation method achieves a 100%voltage compliance rate and reduces network losses by 13.8%,while ensuring three-phase power balance compensation.This provides a practical solution for the modernization and upgrading of low-voltage power grids.展开更多
This article evaluates the connectivity with energy sharing in low-voltage distribution areas.Indicators like wind-solar complementing effectiveness,source-load energy sharing possibility,or transformer capacity inter...This article evaluates the connectivity with energy sharing in low-voltage distribution areas.Indicators like wind-solar complementing effectiveness,source-load energy sharing possibility,or transformer capacity interconnection measurements are part of the assessment index framework for interconnection capacity that is established after an analysis of the features of linked scenarios.Radial and inflexible,conventional distribution systems can’t handle bidirectional power flow,fluctuating demand,or grid disruptions.Using real-world examples,we can see that the suggested strategy improves power supply efficiency across zones and increases the usage of distributed energy resources,proving the method’s validity.With the help of Flexible Interconnection Devices(FIDs),MV/LV networks may be reconfigured,power quality is improved,DERs are supported,and reliability is increased.With so many distributed PVs connected to distribution substations,managing low-and medium-voltage distribution networks is a real challenge.One novel kind of power gadget that permits adaptable connections between distribution substation segments is the soft open point(SOP).This article presents learning algorithm for low and medium voltage networks for power optimization,which takes into consideration the dynamic connectivity of different areas of substation.The next stage is to construct a multi-agent deep reinforcement learning(DRL)suitable for low and medium voltage distribution networks using Deep Q Network(DQN)model in DRL.The low and medium voltage distribution network employs flexible interconnection device for power loss reduction.Finally,the case studies show that the proposed approach has a good operating strategy for distribution networks with medium and low voltages,and it may lessen voltage fluctuations caused by high PV integration.展开更多
The exponential growth of artificial intelligence(AI),large language models,and hyperscale data centers is rapidly reshaping the requirements for data communication infrastructure.As electrical interconnects approach ...The exponential growth of artificial intelligence(AI),large language models,and hyperscale data centers is rapidly reshaping the requirements for data communication infrastructure.As electrical interconnects approach their fundamental limits in bandwidth density and energy efficiency,co-packaged optics(CPO)has emerged as a compelling paradigm to overcome these bottlenecks.By integrating photonic engines in close proximity to application-specific integrated circuits(ASICs),CPO minimizes electrical link lengths,reduces power consumption,and enables unprecedented bandwidth scaling.At the same time,this tight integration introduces new challenges spanning materials,device design,packaging,thermal management,and system architecture.展开更多
With the large-scale deployment of satellite constellations and the rapid advancement of technologies including artificial intelligence(AI)and non-terrestrial networks(NTNs),the integration of high,medium,and low Eart...With the large-scale deployment of satellite constellations and the rapid advancement of technologies including artificial intelligence(AI)and non-terrestrial networks(NTNs),the integration of high,medium,and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies.The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services,facilitating intelligent interconnection and collaborative symbiosis among humans,machines,and objects.This integration has become a central focus of global technological innovation.展开更多
The explosive growth of artificial intelligence(AI)computing,particularly large-scale model training and inference in GPU and accelerator clusters,is driving unprecedented demand for interconnects that deliver high ba...The explosive growth of artificial intelligence(AI)computing,particularly large-scale model training and inference in GPU and accelerator clusters,is driving unprecedented demand for interconnects that deliver high bandwidth,low latency,and strong energy efficiency.As electrical links increasingly run into limits in bandwidth density,power consumption,and signal integrity,optical interconnects have emerged as a key enabling technology for next-generation AI systems.In this context,continued scaling of co-packaged optics and wafer-level photonic integration will require not only high-speed photodetectors,but also manufacturable packaging solutions that can support massive parallel optical input/output(I/O)at lower cost and power.展开更多
Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency devia...Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency deviations,voltage fluctuations,and poor reactive power coordination,posing serious challenges to grid stability.Conventional Interconnection FlowControllers(IFCs)primarily regulate active power flowand fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks.To overcome these limitations,this study proposes an enhanced Interconnection Flow Controller(e-IFC)that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller(IRFC)within a unified adaptive control structure.The proposed e-IFC is implemented and analyzed in DIgSILENT PowerFactory to evaluate its performance under various grid disturbances,including frequency drops,load changes,and reactive power fluctuations.Simulation results reveal that the e-IFC achieves 27.4% higher active power sharing accuracy,19.6% lower reactive power deviation,and 18.2% improved frequency stability compared to the conventional IFC.The adaptive controller ensures seamless transitions between grid-connected and islanded modes and maintains stable operation even under communication delays and data noise.Overall,the proposed e-IFCsignificantly enhances active-reactive power coordination and dynamic stability in renewable-integrated multi-microgrid systems.Future research will focus on coupling the e-IFC with tertiary-level optimization frameworks and conducting hardware-in-the-loop validation to enable its application in large-scale smart microgrid environments.展开更多
Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system th...Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system that overcomes these challenges by combining electrospun SEBS nanofiber mats,high-resolution liquid metal conductors patterned via thermal imprinting(50μm),and a strain isolators(SIL)that protects vertical interconnects(VIAs)from stress concentration.This architecture achieves ultrahigh air permeability(>5.09 m L cm-2min-1),exceptional stretchability(750%fracture strain),and reliable conductivity maintained through more than 32,500 strain cycles.Leveraging these advances,we have integrated multilayer circuits,strain sensors,and a three-axis accelerometer to achieve a fully integrated,stretchable,permeable wireless real-time gesture recognition glove.The system enables accurate sign language interpretation(98%)and seamless robotic hand control,demonstrating its potential for assistive technologies.By uniting comfort,durability,and high-density integration,this work establishes a versatile platform for nextgeneration wearable electronics and interactive human-robot interfaces.展开更多
Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet ...Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as sintering.Herein,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal growth.The calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO3Ap)through dissolution–precipitation reactions.Thus,CO3Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO3Ap-15 and CO3Ap-30,respectively.At 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO3Ap-30,whereas little bone was formed in the center region of CO3Ap-15.At 12 weeks after implantation,a large portion of CO3Ap-30 was replaced with new bone and the boundary with the host bone became blurred.In contrast,CO3Ap-15 remained in the defect and the boundary with the host bone was still clear.Thus,the interconnected pores promote bone ingrowth,followed by replacement of the material with new bone.These findings provide a useful guide for designing bone substitutes for rapid bone regeneration.展开更多
基金supported by grants from Shenzhen Key Medical Subject(No.SZXK023)Shenzhen“SanMing”Project of Medicine(No.SZSM201612092)+3 种基金Shenzhen Research and Development Projects(No.JCYJ20170307111755218)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011290)National Key Research and Development Program of China(No.2016YFC1102103)China Postdoctoral Science Foundation(No.2020M672756)
摘要Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences[grant number XDA19020201].
摘要Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.In all phases of disaster risk management including forecasting,emergency response and post-disaster reconstruction,the need for interconnected multidisciplinary open data for collaborative reporting as well as study and analysis are apparent,in order to determine disaster impact data in timely and reportable manner.The extraordinary progress in computing and information technology in the past decade,such as broad local and wide-area network connectivity(e.g.Internet),highperformance computing,service and cloud computing,big data methods and mobile devices,provides the technical foundation for connecting open data to support disaster risk research.A new generation of disaster data infrastructure based on interconnected open data is evolving rapidly.There are two levels in the conceptual model of Linked Open Data for Global Disaster Risk Research(LODGD)Working Group of the Committee on Data for Science and Technology(CODATA),which is the Committee on Data of the International Council for Science(ICSU):data characterization and data connection.In data characterization,the knowledge about disaster taxonomy and data dependency on disaster events requires specific scientific study as it aims to understand and present the correlation between specific disaster events and scientific data through the integration of literature analysis and semantic knowledge discovery.Data connection concepts deal with technical methods to connect distributed data resources identified by data characterization of disaster type.In the science community,interconnected open data for disaster risk impact assessment are beginning to influence how disaster data are shared,and this will need to extend data coverage and provide better ways of utilizing data across domains where innovation and integration are now necessarily needed.
基金supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A4A01014136)
摘要Porous hydroxyapatite (HA)-tricalcium phosphate (TCP) ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates (DCPD) were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity (- 85%) was observed in the Ca-P scaffold with the lowest HA (-7%) content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content ( - 85%). X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.
基金supported in part by the Rosetrees Trust(#CF-2023-I-2_113)by the Israel Ministry of Innovation,Science,and Technology(#7393)(to ES).
摘要The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.
基金financial support from the National Natural Science Foundation of China (Nos.82473887 and 21927808)the Scientific and Technological Innovation Program of Shanghai (No.23DZ2202500)the CAMS Innovation Fund for Medical Sciences (No.2021-1-I2M-026)。
摘要The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFB2803100)。
摘要We demonstrate a fully integrated eight-channel dense wavelength-division multiplexing silicon photonic transceiver supporting 200-Gbps per-channel PAM4 operation,enabling a total chip-to-chip data rate of 1.6 Tbps.The transmitter employs compact single-bus microring modulators,whereas the receiver adopts a polarization diversity architecture based on cascaded dual-ring filters and integrates a bidirectionally incident photodetector,maintaining stable performance under arbitrary input polarization.A unified multichannel thermo-optic feedback architecture is implemented at both the transmitter and receiver,enabling cooperative link-level wavelength alignment without pre-calibration.This multi-channel parallel control scheme reduces wavelength locking time by~30×while achieving fine wavelength-tracking accuracy of 2.74 pm with negligible thermal overhead.Comprehensive device-and system-level experiments validate the robustness and scalability of the proposed architecture.We uniquely address the critical bottlenecks of high polarization sensitivity and latency in wavelength alignment through a highly integrated silicon photonic architecture.By implementing polarization-splitting grating couplers and synchronized wavelengthlocking schemes,we provide a transformative solution for high-density co-packaged optics.Our approach significantly reduces system footprint,enhances operational reliability,and improves power efficiency,thereby bridging the gap between laboratory demonstrations and practical 1.6-Tbps scale chip-to-chip interconnects.
基金support from USA NSF(Grant No.OPP2213875)NASA(Grant No.80NSSC22K1707).
摘要The IUGG Associations for Atmosphere,Oceans and Cryosphere—IAMAS,IAPSO and IACS—held a Joint Scientific Assembly in Busan,South Korea,from 20 to 25 July 2025.This was the first joint assembly of all three associations since 2009,when they met in Montreal,Canada.It was the first time any of the associations had been hosted in Korea,and it had been two decades since any of them had met in Asia.The choice of Busan as the venue supported high levels of participation and smooth conference operations.The Local Organizing Committee,chaired by Prof.Kyung-Ja Ha of Pusan National University,oversaw the successful organization of the event.The assembly brought together 1725 participants in total,including 1282 researchers and 443 invited participants and individuals involved in side events,exhibitions,media coverage,and volunteer work.Participants came from 46 countries across Asia,Europe,North America,South America,Africa,and Oceania.IAMAS had 736 participants,IAPSO 321,and IACS 225.Survey data from 951 respondents revealed that Early Career Scientists,defined as those within 10 years of receiving their PhD,accounted for approximately 25%of participants.The demographic profile skewed young,with 66%of attendees in their 20s and 30s.The scientific program was organized by Prof.Seon-Ki Park(Chair),the Secretaries General from all three Associations,and the Local Organizing Committee.Reflecting the theme“Our Interconnected Earth,”the scientific program emphasized integrated approaches to climate systems,addressing climate change and environmental challenges through collaborative,transdisciplinary research.
基金financially supported by the Science and Technology Foundation of Henan Province(Grant No.252102320338)the Funding Plan of Key Scientific Research Projects in Colleges and Universities of Henan Province(Grant No.26A530001).
摘要The development of lightweight,high‐attenuation,and broadband carbon‐based electromagnetic wave absorbers is hindered by the intrinsic trade‐off between impedance matching and dielectric dissipation.Herein,we report a facile and scalable synthesis of N‐doped lignin‐derived interconnected porous carbon(Nx‐LIPC)via hydrogen‐bond self‐assembly and subsequent pyrolysis.The synergistic integration of the interconnected porous architecture with multi‐configurational N doping substantially boosts the absorption performance.At an exceptionally low filler loading of 3 wt%,the optimized N0.5‐LIPC achieves a minimum reflection loss of−48.07 dB with a thin matching thickness of 1.9 mm.This performance represents a 350%and 130%enhancement in attenuation intensity compared with the counterparts with only nitrogen doping(N0.5‐LC)or only structural regulation(N0‐LIPC),respectively.Furthermore,N0.5‐LIPC exhibits a broad effective absorption bandwidth of 6.17 GHz at a thickness of 1.7 mm.Mechanistic studies reveal that the three‐dimensional(3D)interconnected network not only facilitates multiple internal reflections and optimizes impedance matching but also strengthens conductive and interfacial polarization losses.Critically,density functional theory calculations corroborate that N incorporation,particularly pyrrolic and pyridinic N,generates strong localized dipoles,introducing additional dipolar polarization loss.This work offers an innovative and sustainable strategy for fabricating high‐performance carbon‐based absorbers from biomass resources.
基金co-supported by the civil aerospace foreign technical cooperation project of China(No.ZB02)the civil aerospace pre research project of China(Nos.D030102,D040102).
摘要The existing studies on spacecraft focus on improving the networked,intelligent,and autonomous level of avionics systems.This paper reviews the research status of spacecraft avionics system architecture and typical spacecraft avionics system,as well as the technical features and potential trends of key technologies,such as network interconnection,high-speed bus,onboard computing,autonomous operation,and software-defined technology.A development roadmap,a novel kind of intelligent system architecture and application scenarios of avionics systems are then proposed.To tackle the challenges faced in the development of spacecraft avionics systems,suggestions are made from the aspects of system architecture,heterogeneous network interconnection,on-orbit intelligent information processing,Commercial Off-The-Shelf(COTS)products application,and intelligent autonomous management.This provides a guide for the related studies on the development of spacecraft avionics technology.
基金supported by the National Natural Science Foundation of China(Grant Nos.62405250 and 62471404)the China Postdoctoral Science Foundation(Grant No.2024M762955)+1 种基金the Key Project of Westlake Institute for Optoelectronics(Grant No.2023GD003)the Optical Communication and Sensing Laboratory,School of Engineering,Westlake University。
摘要The advent of artificial intelligence,cloud services,and big data applications has propelled the evolution of next-generation high-capacity datacenters.It is highly anticipated that coherent detection will penetrate further into datacenters in the next decade.However,the large number of tunable lasers in data centers makes the optical module structure complex and adds additional thermal power consumption.Meanwhile,optical frequency combs serve as high-precision frequency resolution and wide spectral coverage lasers,holding tremendous potential for the field of wavelength division multiplexing optical communication.Here,we present an innovative global frequency-synchronous optical network(globalFSON)architecture for coherent short-reach optical interconnects by synchronizing optical frequency combs to a global positioning system disciplined oscillator(GPSDO)and distributing them.The globalFSON architecture can share GPS-referenced optical frequency combs as master lasers among different servers,which eliminates the need for a massive number of tunable lasers in datacenter optical interconnects.On this basis,we achieve a reset-free carrier phase recovery analog coherent receiver in the optical domain and demonstrate dual-polarization coherent signals demultiplexing without coherent silicon applicationspecific integrated circuits.We introduce the global-FSON architecture that provides a laser source with absolute stability for all transponders in datacenter coherent optical interconnects.Its implementation would bolster the potential applicability of coherent optical communication in next-generation datacenter coherent optical interconnects.
摘要Load frequency control(LFC)in interconnected power systems has always been a challenging task in the presence of uncertainty and variability in the power systems arising primarily due to the integration of renewable energy sources and the impact of electric vehicles on the power system.Although various PI/PID and other advanced control strategies have been employed for LFC in power systems,the existing methods have shown some limitations in terms of dynamic flexibility and robustness in the presence of nonlinearities and couplings in the power systems.Moreover,the optimization methods employed for the tuning of the controllers have shown some limitations in terms of the balance between global and local search abilities of the optimization functions.To overcome the limitations of the existing methods and optimization functions,a hybrid Modified Zebra Optimization Algorithm-Particle Swarm Optimization(MZOA-PSO)is presented in this paper for the optimization of a cascaded PI(1+DD)-PI-PID controller for LFC in power systems.The MZOA enhances the original ZOA by chaotic initialization,adaptive parameter control,and Lévy-flight foraging to improve the global search ability,while PSO ensures efficient local search ability.The optimizer is first validated using four benchmark functions,achieving the global optimum for the Booth and Zakharov functions,a mean value of 2.13×10−28 with a 98%success rate for Rosenbrock,and 3.21×10−81 for Schwefel 2.22.Under a 1%step load perturbation,the proposed controller achieves a 13 s settling time,zero negative deviation in Area 2,a maximum positive excursion of 0.10 Hz,and tie-line undershoot limited to−0.10 p.u.Under random load variations,deviations remain within±0.03 Hz and±0.02 p.u.Under RES and EV integration,the peak frequency deviation is reduced to 0.46 Hz in Area 1.These results confirm that the proposed hybrid MZOA-PSO tuned cascaded controller provides improved damping,faster stabilization,and stronger robustness for modern interconnected LFC systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.52366009 and 52130607).
摘要To investigate transient flow instabilities in parallel-channel regenerative cooling systems subjected to nonuniform heat flux,a three-dimensional transient numerical model was developed to couple variations in supercritical fluid thermophysical properties with endothermic pyrolysis kinetics.The spatiotemporal evolution of RP-3 fuel within parallel channels was analyzed,and the role of a midstream interconnection structure in mitigating flow maldistribution was clarified.During the initial heating stage,the viscosity reduction of the supercritical fuel produced a drag-reduction effect that temporarily maintained a nearly uniform flow distribution.As the wall temperature increased and the pseudocritical region approached,the sharp decrease in density markedly increased the acceleration pressure drop,disrupting the pressure balance between channels.In combination with the progressive accumulation of pyrolysis products,this process led to a positive feedback loop characterized by flow rate reduction,insufficient heat absorption,and increasing flow resistance.The introduction of a midstream interconnection enabled pressure-driven lateral mass transfer between channels.The resulting crossflow was directed predominantly from the high-heat-flux channel toward the low-heat-flux channel,providing a release path for overheated,low-density,and strongly cracked fluid in the high-heat-flux channel and thereby weakening the downstream accumulation of thermal and compositional nonuniformities as well as the associated resistance amplification.Compared with the configuration without interconnection,the stage-averaged maximum flow-deviation coefficient decreased by 17.4%during the pseudocritical transition stage and by 48.3%during the deep-pyrolysis stage.
基金supported by the key technology project of China Southern Power Grid Corporation(GZKJXM20220041)partly by the National Key Research and Development Plan(2022YFE0205300).
摘要This paper presents an optimal operation method for embedded DC interconnections based on low-voltage AC/DC distribution areas(EDC-LVDA)under three-phase unbalanced compensation conditions.It can optimally determine the transmission power of the DC and AC paths to simultaneously improve voltage quality and reduce losses.First,considering the embedded interconnected,unbalanced power structure of the distribution area,a power flow calculation method for EDC-LVDA that accounts for three-phase unbalanced compensation is introduced.This method accurately describes the power flow distribution characteristics under both AC and DC power allocation scenarios.Second,an optimization scheduling model for EDC-LVDA under three-phase unbalanced conditions is developed,incorporating network losses,voltage quality,DC link losses,and unbalance levels.The proposed model employs an improved particle swarm optimization(IPSO)two-layer algorithm to autonomously select different power allocation coefficients for the DC link and AC section under various operating conditions.This enables embedded economic optimization scheduling while maintaining compensation for unbalanced conditions.Finally,a case study based on the IEEE 13-node system for EDC-LVDA is conducted and tested.The results show that the proposed optimal operation method achieves a 100%voltage compliance rate and reduces network losses by 13.8%,while ensuring three-phase power balance compensation.This provides a practical solution for the modernization and upgrading of low-voltage power grids.
基金State Grid Hebei Electric Power Co.,Ltd.(Hebei Huizhi Electric Power Engineering Design Co.,Ltd.)science and technology project funding(SGHEHZ00SJQT2400042)。
摘要This article evaluates the connectivity with energy sharing in low-voltage distribution areas.Indicators like wind-solar complementing effectiveness,source-load energy sharing possibility,or transformer capacity interconnection measurements are part of the assessment index framework for interconnection capacity that is established after an analysis of the features of linked scenarios.Radial and inflexible,conventional distribution systems can’t handle bidirectional power flow,fluctuating demand,or grid disruptions.Using real-world examples,we can see that the suggested strategy improves power supply efficiency across zones and increases the usage of distributed energy resources,proving the method’s validity.With the help of Flexible Interconnection Devices(FIDs),MV/LV networks may be reconfigured,power quality is improved,DERs are supported,and reliability is increased.With so many distributed PVs connected to distribution substations,managing low-and medium-voltage distribution networks is a real challenge.One novel kind of power gadget that permits adaptable connections between distribution substation segments is the soft open point(SOP).This article presents learning algorithm for low and medium voltage networks for power optimization,which takes into consideration the dynamic connectivity of different areas of substation.The next stage is to construct a multi-agent deep reinforcement learning(DRL)suitable for low and medium voltage distribution networks using Deep Q Network(DQN)model in DRL.The low and medium voltage distribution network employs flexible interconnection device for power loss reduction.Finally,the case studies show that the proposed approach has a good operating strategy for distribution networks with medium and low voltages,and it may lessen voltage fluctuations caused by high PV integration.
摘要The exponential growth of artificial intelligence(AI),large language models,and hyperscale data centers is rapidly reshaping the requirements for data communication infrastructure.As electrical interconnects approach their fundamental limits in bandwidth density and energy efficiency,co-packaged optics(CPO)has emerged as a compelling paradigm to overcome these bottlenecks.By integrating photonic engines in close proximity to application-specific integrated circuits(ASICs),CPO minimizes electrical link lengths,reduces power consumption,and enables unprecedented bandwidth scaling.At the same time,this tight integration introduces new challenges spanning materials,device design,packaging,thermal management,and system architecture.
摘要With the large-scale deployment of satellite constellations and the rapid advancement of technologies including artificial intelligence(AI)and non-terrestrial networks(NTNs),the integration of high,medium,and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies.The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services,facilitating intelligent interconnection and collaborative symbiosis among humans,machines,and objects.This integration has become a central focus of global technological innovation.
摘要The explosive growth of artificial intelligence(AI)computing,particularly large-scale model training and inference in GPU and accelerator clusters,is driving unprecedented demand for interconnects that deliver high bandwidth,low latency,and strong energy efficiency.As electrical links increasingly run into limits in bandwidth density,power consumption,and signal integrity,optical interconnects have emerged as a key enabling technology for next-generation AI systems.In this context,continued scaling of co-packaged optics and wafer-level photonic integration will require not only high-speed photodetectors,but also manufacturable packaging solutions that can support massive parallel optical input/output(I/O)at lower cost and power.
基金the Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia,for funding this research work through the project number“NBU-FFR-2025-3623-11”.
摘要Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency deviations,voltage fluctuations,and poor reactive power coordination,posing serious challenges to grid stability.Conventional Interconnection FlowControllers(IFCs)primarily regulate active power flowand fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks.To overcome these limitations,this study proposes an enhanced Interconnection Flow Controller(e-IFC)that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller(IRFC)within a unified adaptive control structure.The proposed e-IFC is implemented and analyzed in DIgSILENT PowerFactory to evaluate its performance under various grid disturbances,including frequency drops,load changes,and reactive power fluctuations.Simulation results reveal that the e-IFC achieves 27.4% higher active power sharing accuracy,19.6% lower reactive power deviation,and 18.2% improved frequency stability compared to the conventional IFC.The adaptive controller ensures seamless transitions between grid-connected and islanded modes and maintains stable operation even under communication delays and data noise.Overall,the proposed e-IFCsignificantly enhances active-reactive power coordination and dynamic stability in renewable-integrated multi-microgrid systems.Future research will focus on coupling the e-IFC with tertiary-level optimization frameworks and conducting hardware-in-the-loop validation to enable its application in large-scale smart microgrid environments.
基金supported in part by the National Key R&D Program of China under Grant 2024YFB4405300 and 2022YFA1204300the Natural Science Foundation of Hunan Province under Grant 2023JJ20016+2 种基金the National Natural Science Foundation of China under Grants of 52221001 and 62090035the Key Research and Development Plan of Hunan Province under grants of 2022GK3002 and 2023GK2012the Key Program of Science and Technology Department of Hunan Province under grant of 2020XK2001。
摘要Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system that overcomes these challenges by combining electrospun SEBS nanofiber mats,high-resolution liquid metal conductors patterned via thermal imprinting(50μm),and a strain isolators(SIL)that protects vertical interconnects(VIAs)from stress concentration.This architecture achieves ultrahigh air permeability(>5.09 m L cm-2min-1),exceptional stretchability(750%fracture strain),and reliable conductivity maintained through more than 32,500 strain cycles.Leveraging these advances,we have integrated multilayer circuits,strain sensors,and a three-axis accelerometer to achieve a fully integrated,stretchable,permeable wireless real-time gesture recognition glove.The system enables accurate sign language interpretation(98%)and seamless robotic hand control,demonstrating its potential for assistive technologies.By uniting comfort,durability,and high-density integration,this work establishes a versatile platform for nextgeneration wearable electronics and interactive human-robot interfaces.
摘要Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as sintering.Herein,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal growth.The calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO3Ap)through dissolution–precipitation reactions.Thus,CO3Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO3Ap-15 and CO3Ap-30,respectively.At 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO3Ap-30,whereas little bone was formed in the center region of CO3Ap-15.At 12 weeks after implantation,a large portion of CO3Ap-30 was replaced with new bone and the boundary with the host bone became blurred.In contrast,CO3Ap-15 remained in the defect and the boundary with the host bone was still clear.Thus,the interconnected pores promote bone ingrowth,followed by replacement of the material with new bone.These findings provide a useful guide for designing bone substitutes for rapid bone regeneration.