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Interferon regulatory factor 1 enhances T cell differentiation in patients with myasthenia gravis 认领 引用 被引量：1
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作者 Yuebei Luo Yijun Ren +3 位作者 Zeyi Wen Zhaohui Luo Huan Yang Liqun Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3267-3280,共14页
Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of... Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of interferon regulatory factor 1 in myasthenia gravis,with an aim to understand the underlying mechanisms.Patients with myasthenia gravis who had acetylcholine receptor antibodies were included in the study.Peripheral blood lymphocytes were extracted from the included patients,and B lymphocyte subsets were isolated.Next,T and B cells from peripheral blood were co-cultured to explore the interferon regulatory factor 1-related mechanisms in myasthenia gravis.Chromatin immunoprecipitation experiments confirmed an interaction between interferon regulatory factor 1 and the CD180 promoter region.Dual-luciferase reporter gene confirmed the transcriptional activity of interferon regulatory factor 1 on CD180 promoter.In vitro results further indicated that interferon regulatory factor 1 promoted B cell activation and T cell differentiation via the inhibition of CD180.Interferon regulatory factor 1 recruited histone deacetylase 1 to inhibit CD180 transcription.Additionally,histone deacetylase 1 promoted B cell activation and T cell differentiation.Finally,in vitro experiments demonstrated that CD180 inhibited B cell activation and T cell differentiation by inhibiting the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Collectively,our results suggest that interferon regulatory factor 1 enhances T cell differentiation by recruiting histone deacetylase 1 to block B cell CD180 transcription in myasthenia gravis via the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Together,these findings indicate the important role of interferon regulatory factor 1 in myasthenia gravis and suggest its molecular mechanisms.They also provide new ideas and targets for diagnosing and treating myasthenia gravis,which will be both scientifically and clinically valuable. 展开更多
关键词 autoimmune condition B cell CD180 histone deacetylase 1 interferon regulatory factor 1 mitogen-activated protein kinase myasthenia gravis nuclear factor-kappa B T cell Toll-like receptor 4
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Interferon regulatory factor 4-releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization 认领 引用 被引量：1
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作者 Jianhao Wang Jiawei Du +5 位作者 Tuo Fang Di Zhang Yigang Lv Zhongju Shi Hengxing Zhou Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3706-3716,共11页
Three-dimensional(3D)-printed hydrogel scaffolds are widely used in spinal cord injury repair,with gelatin methacrylate being particularly favored owing to its excellent biocompatibility.However,traditional scaffolds ... Three-dimensional(3D)-printed hydrogel scaffolds are widely used in spinal cord injury repair,with gelatin methacrylate being particularly favored owing to its excellent biocompatibility.However,traditional scaffolds have a small contact area with tissues and lack the ability to regulate the inflammatory microenvironment.Therefore,there is a need to develop smart scaffolds with drug delivery and immune regulation functions.In this study,a 3D-printed gelatin methacrylate scaffold was developed to deliver interferon regulatory factor 4 in a targeted and sustained manner.The scaffold showed good mechanical properties,biocompatibility,and sustained interferon regulatory factor 4 release.The sustained-release interferon regulatory factor 4 competitively bound to myeloid differentiation factor 88 to inhibit the pro-inflammatory effects of interferon regulatory factor 5,and activated the signal transducer and activator of transcription 6 pathway to promote M2 macrophage polarization,thereby facilitating neural regeneration and recovery of spinal cord function.This indicates that the constructed interferon regulatory factor 4-loaded 3D-printed methyl acrylate-modified gelatin scaffold can regulate macrophage polarization through the interferon regulatory factor 4/5 axis,improve the inflammatory microenvironment after spinal cord injury,and thus provide a new target for promoting neural regeneration. 展开更多
关键词 3D-printed scaffold inflammatory microenvironment interferon regulatory factor 4 JAK1/STAT6 signaling pathway macrophage polarization microglia nerve regeneration spinal cord injury
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Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B 认领 引用
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作者 Xiang-Yang Ye Xiong-Zhi He +6 位作者 Zhen-Ting Hu Feng-Feng Zheng Xiao-Gang Huang Xue-Mei Xie Fei-Hua Chen Han-Bing Ou Rong-Xian Qiu 《World Journal of Hepatology》 2026年第4期172-189,共18页
BACKGROUND Chronic hepatitis B(CHB)is a significant global health issue,and interferon(IFN)is one of the main first-line therapies for CHB.AIM To investigate the altered transcriptome,metabolites,and their correlation... BACKGROUND Chronic hepatitis B(CHB)is a significant global health issue,and interferon(IFN)is one of the main first-line therapies for CHB.AIM To investigate the altered transcriptome,metabolites,and their correlations,as well as the effects and mechanisms of IFN treatment for CHB.METHODS The patients received peginterferon alfa-2b at a dose of 180μg for 0,1,3,and 6 months and serum samples were collected for clinical biological assays,transcriptomics,and metabolomics analyses.RESULTS The results showed that IFN-related immune pathways and neutrophil extracellular traps(NETs)were the most significantly altered pathways following IFN treatment.Correlation analysis revealed a strong link between immune system-related genes in the transcriptome and dipeptides in the metabolome during IFN-αtreatment.Notably,core components of NETs,including histones H2A clustered histone 14,H2B clustered histone 5,H3 clustered histone 1,and H4 clustered histone 4,were significantly increased after IFN treatment.The positively charged histones may bind to the negatively charged viral envelope,potentially enhancing the antiviral effect.CONCLUSION Integrated non-targeted transcriptomic and metabolomic analyses to CHB patients undergoing IFN-αtreatment revealed that IFN-related immune pathways and NETs were the most significantly affected pathways during IFN treatment.These findings provide a deeper understanding of the role of NETs and dipeptides in the antiviral response to IFN treatment for CHB. 展开更多
关键词 Interferon Neutrophil extracellular trap Chronic hepatitis B Hepatitis B virus Transcriptomic and metabolomic
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Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B:A retrospective study 认领 引用
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作者 Fei Yan Xiu-Lan Xue +20 位作者 Ying Guo Qi-Ran Zhang Rui-Rui You Jia Shang Xiao-Ping Wu Jia-Wei Geng Xiao-Hong Gao Qing Ye Jing Liang Xiao-Yan Wang Jian-Yong Zeng Jing Chen Yi-Cheng Lin Xin-Yu Chen Qin Du Wei-Li Yin Lei Liu Fang Wang Bai-Guo Xu Wen-Hong Zhang Hui-Ling Xiang 《World Journal of Gastroenterology》 SCIE CAS 2026年第12期62-76,共15页
BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.Wh... BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.While a 48-week interferon course is standard,extended therapy may improve HBsAg clearance rates.However,there exists a notable gap in predictive modeling studies concerning extended treatment courses(≥48 weeks).AIM To develop a predictive model for identifying patients who require extended interferon therapy(≥48 weeks)for HBsAg clearance.METHODS This multicenter retrospective study included CHB patients,including those with compensated cirrhosis,who achieved HBsAg clearance(HBsAg<0.05 IU/mL)following treatment with pegylated interferon alpha-2b,either alone or in combination with nucleoside analogs.After propensity score matching,we employed least absolute shrinkage and selection operator(LASSO)regression and multivariate regression to identify independent predictors.RESULTS A total of 688 eligible patients with CHB were enrolled in this study.After propensity score matching at a 1:1 ratio,375 patients remained,including 196 in the training cohort.Among the training cohort,36(18.37%)were classified in the extended course(≥48 weeks)and 160(81.63%)in the regular course(<48 weeks).LASSO and multivariate regression analyses identified baseline HBsAg and cirrhosis as significant risk factors for extended interferon therapy.The model demonstrated strong discriminatory ability,with the area under the curve of 0.83[95%confidence interval(CI):0.76-0.91]for the training cohort and 0.81(95%CI:0.71-0.90)for the externally validated cohort.The model’s predictive efficacy was not influenced by subgroup characteristics.CONCLUSION This study successfully constructed and validated a prediction model based on baseline HBsAg and cirrhosis to identify potential populations that may benefit from extended interferon therapy(≥48 weeks). 展开更多
关键词 Chronic hepatitis B Clinical cure Extended course of interferon Hepatitis B surface antigen Prediction model
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Two orthobunyaviruses:OYAV and EBIV co-opt the AhR-CYP1A1 axis to suppress type I interferon responses 认领 引用
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作者 Qianyun Hu Fei Wang +4 位作者 Xiaoyu Wang Xiaokui Li Zhiming Yuan Maohua Zhong Han Xia 《Virologica Sinica》 SCIE CAS CSCD 2026年第2期329-342,共14页
The type I interferon(IFN-I)system serves as a frontline defense against viral infection,yet how orthobunyaviruses counteract this pathway remains poorly defined.Here,we identify cytochrome P4501A1(CYP1A1)as a crucial... The type I interferon(IFN-I)system serves as a frontline defense against viral infection,yet how orthobunyaviruses counteract this pathway remains poorly defined.Here,we identify cytochrome P4501A1(CYP1A1)as a crucial host factor promoting infection by two emerging orthobunyaviruses-Oya virus(OYAV)and Ebinur Lake virus(EBIV).Transcriptomic and functional analyses demonstrate that CYP1A1 overexpression enhances viral RNA synthesis,whereas its CRISPR-Cas9mediated knockout attenuates infection.Mechanistically,OYAV and EBIV activate the aryl hydrocarbon receptor(AhR),driving its nuclear translocation and subsequent upregulation of CYP1A1.Deficiency of CYP1A1 potentiates IFN-βproduction and interferon-stimulated gene(ISG)expression,while its overexpression suppressed antiviral signaling,revealing an immunomodulatory role that is distinct from its canonical metabolic function.Collectively,this work defines the AhR-CYP1A1 axis as a conserved immune-evasion module exploited by emerging orthobunyaviruses and highlights the innate immune pathway as a potential therapeutic target against these emerging threats. 展开更多
关键词 Orthobunyavirus Cytochrome P4501A1(CYP1A1) Type I interferon(IFN-I) Aryl hydrocarbon receptor(AhR) Immune evasion
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Effects of pegylated interferon on T cell receptor fingerprints in chronic hepatitis B patients with/without surface antigen clearance 认领 引用
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作者 Kun-Yan Hao Lei Tang +4 位作者 Guo-Bing Chen Wei Guo Zhan-Hui Wang Li-Peng Mao Yue-Cheng Yu 《World Journal of Hepatology》 2026年第7期73-84,共12页
BACKGROUND Chronic hepatitis B(CHB)remains a critical global health challenge,with few patients achieving spontaneous clearance of hepatitis B surface antigen(HBsAg),which is a key indicator of functional cure.T cell ... BACKGROUND Chronic hepatitis B(CHB)remains a critical global health challenge,with few patients achieving spontaneous clearance of hepatitis B surface antigen(HBsAg),which is a key indicator of functional cure.T cell plays an important role in HBsAg clearance.AIM To compare T cell receptor(TCR)fingerprints between patients with or without HBsAg clearance after pegylated interferon alpha-2b(PegIFNα-2b)added on nucleos(t)ide analogues(NAs).METHODS In this observational study,peripheral blood mononuclear cells(PBMCs)were isolated from six comparable CHB patients who achieved HBsAg clearance(Group-C)or not(Group-NC)after 48 weeks of PegIFNα-2b added to NA therapy.Patients in Group-C and Group-NC had comparable age,gender,baseline hepatitis B virus(HBV)DNA,HBsAg,hepatitis B envelop antigen(HBeAg),total bilirubin,alanine aminotransferase(ALT)and cirrhosis status.All patients had received at least one year of NA before PegIFNα-2b therapy.TCR repertoire profiles(fingerprints)were screened and compared by RNA sequencing and bioinformation analysis between the two groups.RESULTS Six male patients without cirrhosis were enrolled in this study,with three patients in each group.200 ng of RNA from each PBMC sample was extracted for standard RNA sequencing for construction of a complementary DNA library.Baseline levels of HBsAg,HBeAg,HBV DNA(0.05).It was found that compared to Group-NC,Group-C had significantly higher TCR diversity in bothαandβchain,including more unique clonotypes(P=0.017,P=0.038 respectively),more repertoire overlap(P=0.002,P=0.002 respectively),a broader complementarity-determining region3 length distribution,and higher Chao1 index(P=0.016,P=0.048 respectively).CONCLUSION Patients with HBsAg clearance had a more diverse and robust T cell response,which may correlate with HBsAg clearance status.These immune signatures may serve as potential reference indicators for PegIFNα-2b treatment response in CHB patients. 展开更多
关键词 Hepatitis B surface antigen clearance Pegylated interferonα-2b T cell receptor diversity Complementaritydetermining region 3 RNA sequencing Fingerprints
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease 认领 引用 被引量：3
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作者 Shengyang Zhou Ting Li +8 位作者 Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第8期2361-2372,共12页
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report... Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease. 展开更多
关键词 cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon
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Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B 认领 引用 被引量：1
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作者 Yan-Chao Fu Jun Li +8 位作者 Jia-Yin Wang Yi-Wen Zhang Fei Yan Jing Chen Qin Du Chao Yang Jing Liang Qing Ye Hui-Ling Xiang 《World Journal of Gastroenterology》 SCIE CAS 2025年第44期94-106,共13页
BACKGROUND Chronic hepatitis B(CHB)patients rarely achieve functional cure with initial pegylated interferon alpha-2b(Peg-IFNα-2b)therapy.Validated tools to guide retreatment candidates are lacking.We hypothesized th... BACKGROUND Chronic hepatitis B(CHB)patients rarely achieve functional cure with initial pegylated interferon alpha-2b(Peg-IFNα-2b)therapy.Validated tools to guide retreatment candidates are lacking.We hypothesized that clinical indicators predict hepatitis B surface antigen(HBsAg)clearance during retreatment.AIM To develop a prediction model for HBsAg clearance in Peg-IFNα-2b retreatment.METHODS In this retrospective cohort study,we enrolled 135 CHB/compensated cirrhosis patients receiving Peg-IFNα-2b retreatment after initial non-clearance at Tianjin University Central Hospital(2017-2025).Predictors were identified through univariate Cox,least absolute shrinkage and selection operator,and multivariate Cox regression.Model performance was assessed via receiver operating characteristic analysis and Harrell’s C-index,with risk stratification by X-tile optimization.RESULTS HBsAg clearance rate was 20.74%(28/135).Independent predictors included:Combination nucleos(t)ide analogue(NA)therapy during initial treatment[hazard ratio(HR)=0.276,95%confidence interval(CI):0.092-0.833],baseline HBsAg at retreatment(HR=0.571,95%CI:0.410-0.795),HBsAg decline after initial treatment(HR=2.050,95%CI:1.108-3.793),and treatment interval(HR=1.013/week,95%CI:1.008-1.018).The retreatment HBsAg clearance prediction score(RHCP-S)demonstrated area under the curve of 0.920(95%CI:0.863-0.946),sensitivity of 92.3%,specificity of 79.3%.Clearance rates differed significantly:RHCP-S challenge group(≤74 points):3.45%,RHCP-S probable group(74-110 points):29.63%,RHCP-S dominant group(≥110 points):80.95%(P<0.001).CONCLUSION The overall HBsAg clearance rate with Peg-IFNα-2b retreatment was 20.74%(28/135).The RHCP-S model identifies optimal retreatment candidates(≥110 points)with 80.95%clearance probability,associated with the absence of combination NA therapy during initial treatment,greater initial HBsAg decline,longer intervals,and lower retreatment HBsAg. 展开更多
关键词 Chronic hepatitis B Retreatment Pegylated interferon alpha Hepatitis B surface antigen clearance Prediction model
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Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma 认领 引用 被引量：1
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作者 Ai-Yu Nie Zhong-Hui Xiao +4 位作者 Jia-Li Deng Na Li Li-Yuan Hao Sheng-Hao Li Xiao-Yu Hu 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第2期246-261,共16页
BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS... BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune responses.As a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in HCC.However,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor cells.AIM To investigate the dual-regulation mechanism of cGAS-STING in HCC.METHODS This review was conducted according to the PRISMA guidelines.The study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science databases.Through rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC tumors.RESULTS All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 studies.After removing duplicates,remaining 964 records were screened.Ultimately,55 articles met the inclusion criteria and were included in this review.CONCLUSION Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its progression.Extended cGAS-STING pathway activation will result in a suppressive tumor microenvironment. 展开更多
关键词 Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology
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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration 认领 引用 被引量：1
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作者 Bryan Sun Lulin Li Jian Luo 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第7期2005-2007,共3页
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of neuroinflammation.While current studies primarily attribute its effects to neurons and glial ce... The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of neuroinflammation.While current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial cells.Therefore,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic interventions.Here,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells. 展开更多
关键词 stimulator interferon inflammation
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Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren’s syndrome 认领 引用 被引量：1
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作者 Jiao Wang Guang-Hong Chu +4 位作者 Zi-Huan Wang Xiao-Yu Cai Si-Yuan Shi Qi-Ping Qing Qi Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2025年第8期1456-1463,共8页
AIM:To investigate the expression of interferon regulatory factors(IRFs)in peripheral blood mononuclear cells(PBMCs)of patients with Sjögren’s syndrome-related dry eye(SSDE)and to explore their correlation with ... AIM:To investigate the expression of interferon regulatory factors(IRFs)in peripheral blood mononuclear cells(PBMCs)of patients with Sjögren’s syndrome-related dry eye(SSDE)and to explore their correlation with clinical features,dendritic cell activation,and serological indicators.METHODS:A total of 53 SSDE patients and 62 non-Sjögren’s syndrome dry eye(NSSDE)patients were enrolled.Demographic and clinical data were collected,and comprehensive ophthalmic examinations were performed,including the ocular surface disease index(OSDI)questionnaires,Schirmer I test(SIT),tear break-up time(TBUT),corneal fluorescein staining score(CFS),and in vivo confocal microscopy(IVCM).PBMCs were isolated,and IRFs expression levels were analyzed using Western blotting(WB)and quantitative real-time polymerase chain reaction(qRT-PCR).Serological indicators,including antinuclear antibodies(ANA)and anti-Ro60,anti-Ro52,and anti-La autoantibodies,were detected.Statistical analyses evaluated correlations between IRFs expression and clinical parameters.RESULTS:Compared to NSSDE,the relative mRNA and protein expression of the IRF-8 was significantly upregulated in patients with SSDE(P<0.001),whereas no significant differences were observed in IRF-1,IRF-3,IRF-5,and IRF-7(P=0.12,P=0.10,P=0.66,P=0.96).Correlation analysis revealed that IRF-8 expression was positively associated with CFS and OSDI scores(r=0.57,r=0.38,both P<0.05).Moreover,IRF-8 expression correlated with corneal dendritic cell(DC)density and size,and the number of dendrites(r=0.43,r=0.40,r=0.65,all P<0.05).IRF-8 expression was significantly elevated in patients positive for anti-Ro60,anti-Ro52 and anti-La autoantibodies(P<0.05).CONCLUSION:In SSDE,IRF-8 is upregulated and associated with clinical features,DC activation,and serological indicators.These findings suggest that IRF-8 plays a critical role in SSDE pathogenesis and may serve as a potential therapeutic target for diagnosis and treatment. 展开更多
关键词 interferon regulatory factors Sjögren’s syndrome dry eye
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Jianpi Yifei Tongluo recipe(健脾益肺通络方剂)attenuates inflammation by promoting the expression of interferon regulatory factor 4 in the rat model of chronic obstructive pulmonary disease 认领 引用
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作者 WANG Wei LONG Qi +1 位作者 FU Ling WU Haiqiao 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第5期1048-1058,共11页
OBJECTIVE:To examine the effects of the Jianpi Yifei Tongluo recipe(健脾益肺通络方剂,JYTR)on chronic obstructive pulmonary disease(COPD)within an animal model and to elucidate its anti-inflammatory mechanisms.METHODS:... OBJECTIVE:To examine the effects of the Jianpi Yifei Tongluo recipe(健脾益肺通络方剂,JYTR)on chronic obstructive pulmonary disease(COPD)within an animal model and to elucidate its anti-inflammatory mechanisms.METHODS:In this study,we utilized cigarette smoke(CS)exposure and lipopolysaccharide(LPS)-induced models of COPD in rats to evaluate the effects of the JYTR on airway inflammation.Sprague-Dawley rats were randomly assigned to various groups:control,model,budesonide,synbiotics,and low,medium,and high JYTR.Pulmonary function was gauged using an animal volumetric tracer.Pathological alterations in lung tissue were examined under a light microscope.To ascertain cytokine production,we conducted enzyme-linked immunosorbent assay tests,and we employed Western blotting to measure the expression levels of interferon regulatory factor 4(IRF4),arginase 1(Arg1),inducible nitric oxide synthase(iNOS),nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha(IKB-α),and P65.RESULTS:Compared to the control group,rats in the COPD model group exhibited significantly compromised pulmonary function and severe inflammatory pathology in the lungs.Treatment with budesonide,synbiotics,and the JYTR markedly improved pulmonary function and diminished the production of inflammatory cytokines transforming growth factor-beta(TGF-β),tumor necrosis factor-alpha(TNF-α),and interleukin-6(IL-6).These improvements were particularly notable in the budesonide group and the high-dose JYTR group.Additionally,the JYTR increased the expression of IRF4 and upregulated the protein expression of Arg1,while concurrently downregulating the protein expression of iNOS,phosphorylated IKB-α,and phosphorylated P65.CONCLUSION:Our current study reveals that JYTR can mitigate inflammatory lung injury,enhance lung function,and lower levels of inflammatory cytokines induced by CS or LPS exposure in COPD model rats.The mechanism behind its anti-inflammatory effect likely involves the regulation of IRF4 expression and M2 polarization through the nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway. 展开更多
关键词 cigarette smoking inflammation pulmonary disease chronic obstructive interferon regulatory factors Jianpi Yifei Tongluo recipe
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Interferon-gamma signaling pathway:Modulation of key genes in the progression of glioblastoma 认领 引用
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作者 Enrique Oropeza-Martínez Eva G Palacios Serrato +4 位作者 Sayra X Zamora-Salas Norma A Lira-Rodríguez Sianka’an HZ López-Mignon Maximo B Martinez-Benitez Angeles C Tecalco-Cruz 《World Journal of Biological Chemistry》 2025年第4期52-64,共13页
The canonical signaling of interferon gamma(IFN-γ)through the Janus kinase 1 and 2–signal transducer and activator of transcription 1(STAT1)axis leads to the expression of several interferon-stimulated genes(ISGs),w... The canonical signaling of interferon gamma(IFN-γ)through the Janus kinase 1 and 2–signal transducer and activator of transcription 1(STAT1)axis leads to the expression of several interferon-stimulated genes(ISGs),which have diverse effects depending on the cellular context.In glioblastoma,a highly aggressive primary brain tumor in adults,elements of IFN-γcanonical signaling are deregulated,resulting in the overexpression of STAT1-target ISGs associated with tumor progression.This mini-review highlights key ISGs,including STAT1,interferon regulatory factor 1,programmed death-ligand 1,indoleamine 2,3-dioxygenase 1,and interferon-stimulated gene 15,involved in the pathology of glioblastoma.These genes may serve as valuable biomarkers and have therapeutic potential for targeting IFN-γsignaling in this malignancy. 展开更多
关键词 Glioblastoma Interferon gamma Janus kinases Interferon-stimulated genes Signal transducer and activator of transcription 1 Interferon regulatory factor 1 B7-H1 antigen Indoleamine-2,3-dioxygenase Interferon-stimulated gene 15 Signal transduction
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Ropeginterferonα-2b治疗骨髓增殖性肿瘤的研究进展 认领 引用
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作者 屠玲榕 黄健 《中国实验血液学杂志》 CAS CSCD 北大核心 2025年第1期306-310,共5页
Ropeginterferonα-2b是新上市的一种长效聚乙二醇脯氨酸α干扰素,是第一种专门批准用于治疗真性红细胞增多症的干扰素,临床试验和经验发现其可以诱导骨髓增殖性肿瘤患者血液学缓解,控制疾病相关症状,降低JAK2V617F基因突变负荷。与聚... Ropeginterferonα-2b是新上市的一种长效聚乙二醇脯氨酸α干扰素,是第一种专门批准用于治疗真性红细胞增多症的干扰素,临床试验和经验发现其可以诱导骨髓增殖性肿瘤患者血液学缓解,控制疾病相关症状,降低JAK2V617F基因突变负荷。与聚乙二醇干扰素α和羟基脲相比,其药物不良反应发生率和严重程度较低,且给药间隔时间更长,部分低危真性红细胞增多症和骨髓纤维化患者也能从中获益。本文就Ropeginterferonα-2b在骨髓增殖性肿瘤中的最新研究进展作一综述。 展开更多
关键词 骨髓增殖性肿瘤 Ropeginterferonα-2b α干扰素 治疗
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3D printing of interferonγ-preconditioned NSC-derived exosomes/collagen/chitosan biological scaffolds for neurological recovery after TBI 认领 引用 被引量：7
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作者 Chong Chen Zhe-Han Chang +8 位作者 Bin Yao Xiao-Yin Liu Xiao-Wang Zhang Jun Liang Jing-Jing Wang Shuang-Qing Bao Meng-Meng Chen Ping Zhu Xiao-Hong Li 《Bioactive Materials》 SCIE CSCD 2024年第9期375-391,共17页
The reconstruction of neural function and recovery of chronic damage following traumatic brain injury(TBI)remain significant clinical challenges.Exosomes derived from neural stem cells(NSCs)offer various benefits inTB... The reconstruction of neural function and recovery of chronic damage following traumatic brain injury(TBI)remain significant clinical challenges.Exosomes derived from neural stem cells(NSCs)offer various benefits inTBI treatment.Numerous studies confirmed that appropriate preconditioning methods enhanced the targetedefficacy of exosome therapy.Interferon-gamma(IFN-γ)possesses immunomodulatory capabilities and is widelyinvolved in neurological disorders.In this study,IFN-γwas employed for preconditioning NSCs to enhance theefficacy of exosome(IFN-Exo,IE)for TBI.miRNA sequencing revealed the potential of IFN-Exo in promotingneural differentiation and modulating inflammatory responses.Through low-temperature 3D printing,IFN-Exowas combined with collagen/chitosan(3D-CC-IE)to preserve the biological activity of the exosome.The deliveryof exosomes via biomaterial scaffolds benefited the retention and therapeutic potential of exosomes,ensuring that they could exert long-term effects at the injury site.The 3D-CC-IE scaffold exhibited excellentbiocompatibility and mechanical properties.Subsequently,3D-CC-IE scaffold significantly improved impairedmotor and cognitive functions after TBI in rat.Histological results showed that 3D-CC-IE scaffold markedlyfacilitated the reconstruction of damaged neural tissue and promoted endogenous neurogenesis.Furthermechanistic validation suggested that IFN-Exo alleviated neuroinflammation by modulating the MAPK/mTORsignaling pathway.In summary,the results of this study indicated that 3D-CC-IE scaffold engaged in long-termpathophysiological processes,fostering neural function recovery after TBI,offering a promising regenerativetherapy avenue. 展开更多
关键词 Exosomes Traumatic brain injury Interferonγ 3D printing Neural reconstruction
Dual regulation of antiviral IFN response by Scutellariae Radix:Therapeutic implications for influenza 认领 引用
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作者 Li Li Manjing Jiang +9 位作者 Hong Wei Linpan Liang Yunlong Song Dongni Xia Qiang Luo Huimin Huang Xu Li Haisheng Yang Lijun Ning Ying Wu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期756-774,共19页
Scutellariae Radix(SR)is widely used in Chinese medicine for influenza treatment;however,the mechanisms underlying its effect remain unknown.Here,we report,for the first time,that the therapeutic effects of SR on infl... Scutellariae Radix(SR)is widely used in Chinese medicine for influenza treatment;however,the mechanisms underlying its effect remain unknown.Here,we report,for the first time,that the therapeutic effects of SR on influenza involve regulation of antiviral interferons(IFNs),typeⅠand typeⅢIFNs(IFN-Is and IFN-Ⅲs,respectively),particularly through the modulation of IFN-I production and its downstream effects in a cell type-specific manner.SR treatment resulted in symptomatic improvement in A/Puerto Rico/8/34(H1N1)virus(PR8)-infected mice.It exhibited direct antiviral activity in the early stages of virus infection in A/WSN/33(H1N1)(WSN)-infected Madin-Darby canine kidney(MDCK)cells.Next,we investigated the effects of SR on the upstream antiviral IFN pathways and downstream effects in human lung adenocarcinoma(A549)cells,human monocytic leukemia(THP-1)cells,and neutrophils(Neu).SR exhibited dual regulatory roles,enhancing the production and activity of antiviral IFNs via the nuclear factor-kappaB(NF-κB)/IFN regulatory factor 3(IRF3)and Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathways.It also reduced IFN-I-induced neutrophil inflammation by inhibiting reactive oxygen species(ROS)and neutrophil extracellular trap(NET)production,and alleviated inflammation in A549 and THP-1 cells via NF-κB/cFOS or mitogen-activated protein kinase(MAPK)/c-Jun signaling.Subsequently,the importance of IFN-Ⅰ/IFN-Ⅲwas verified using IFN alpha receptor 1(Ifnar1)-/-and IFN lambda receptor 1(Ifnlr1)-/-mice.The absence of IFNAR or IFNLR significantly diminished the therapeutic effect of SR against influenza,highlighting its dependence on the IFN-Ⅰ/IFN-Ⅲsystems.Finally,a delayed drug administration experiment in PR8-infected mice revealed that the therapeutic effect of SR heavily relies on early induction of IFN.Overall,our findings offer valuable insights for the clinical utilization of SR,as well as for further exploration of antiviral treatments. 展开更多
关键词 Scutellariae Radix Dual regulation TypeⅠinterferon TypeⅢinterferon Influenza
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Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndrome 认领 引用
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作者 Jiajin Chen Ruili Hou +9 位作者 Xiaowen Xu Ning Xie Jiaqi Tang Yi Li Xiaoqing Nie Nuala J.Meyer Li Su David C.Christiani Feng Chen Ruyang Zhang 《Journal of Biomedical Research》 CAS CSCD 2026年第1期11-22,共12页
Interferon-related genes are involved in antiviral responses,inflammation,and immunity,which are closely related to sepsis-associated acute respiratory distress syndrome(ARDS).We analyzed 1972 participants with genoty... Interferon-related genes are involved in antiviral responses,inflammation,and immunity,which are closely related to sepsis-associated acute respiratory distress syndrome(ARDS).We analyzed 1972 participants with genotype data and 681 participants with gene expression data from the Molecular Epidemiology of ARDS(MEARDS),the Molecular Epidemiology of Sepsis in the ICU(MESSI),and the Molecular Diagnosis and Risk Stratification of Sepsis(MARS)cohorts in a three-step study focusing on sepsis-associated ARDS and sepsis-only controls.First,we identified and validated interferon-related genes associated with sepsis-associated ARDS risk using genetically regulated gene expression(GReX).Second,we examined the association of the confirmed gene(interferon regulatory factor 1,IRF1)with ARDS risk and survival and conducted a mediation analysis.Through discovery and validation,we found that the GReX of IRF1 was associated with ARDS risk(odds ratio[ORMEARDS]=0.84,P=0.008;ORMESSI=0.83,P=0.034).Furthermore,individual-level measured IRF1 expression was associated with reduced ARDS risk(OR=0.58,P=8.67×10-4),and improved overall survival in ARDS patients(hazard ratio[HR28-day]=0.49,P=0.009)and sepsis patients(HR28-day=0.76,P=0.008).Mediation analysis revealed that IRF1 may enhance immune function by regulating the major histocompatibility complex,including HLA-F,which mediated more than 70%of protective effects of IRF1 on ARDS.The findings were validated by in vitro biological experiments including time-series infection dynamics,overexpression,knockout,and chromatin immunoprecipitation sequencing.Early prophylactic interventions to activate IRF1 in sepsis patients,thereby regulating HLA-F,may reduce the risk of ARDS and mortality,especially in severely ill patients. 展开更多
关键词 acute respiratory distress syndrome sepsis interferon regulatory factor 1 causal inference immunity
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表达γ干扰素的重组乳酸菌治疗猫瘟的效果评价 认领 引用
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作者 王威 王瑜琪 +6 位作者 郭飞 孙培文 王煜煜 庞坤 吕长荣 华进联 李娜 《动物医学进展》 北大核心 2026年第1期14-17,共4页
七月龄布偶猫,因近期出现精神沉郁,食欲减退,有轻微拒食和呕吐现象,拉黄色水样粪便,有轻微便血而送动物医院诊疗。经临床检查其基本生命体征未见异常,血常规检验发现病猫白细胞数量显著降低,结合临床症状和猫瘟热试纸检测结果,确诊其患... 七月龄布偶猫,因近期出现精神沉郁,食欲减退,有轻微拒食和呕吐现象,拉黄色水样粪便,有轻微便血而送动物医院诊疗。经临床检查其基本生命体征未见异常,血常规检验发现病猫白细胞数量显著降低,结合临床症状和猫瘟热试纸检测结果,确诊其患有猫瘟。通过每日灌服表达γ干扰素的乳酸菌配合常规药物进行治疗,治疗第3天后患猫的粪便由水样逐渐变为糊状,治疗第5天时,粪便成型,且血常规检测中各项指标基本恢复正常。 展开更多
关键词 猫瘟 γ干扰素 乳酸菌
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Metal‐Organized Nanoassemblies Redefine Systemic STING Immunotherapy 认领 引用
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作者 Zhusheng Huang Sen Liu Zhimin Luo 《Rare Metals》 SCIE EI CAS CSCD 2026年第6期1-4,共4页
1|From STING Promise to Translational Challenges The cyclic GMP‐AMP synthase‐stimulator of interferon genes(cGAS‐STING)pathway has emerged as a central innate immune‐sensing axis and a promising target for cancer ... 1|From STING Promise to Translational Challenges The cyclic GMP‐AMP synthase‐stimulator of interferon genes(cGAS‐STING)pathway has emerged as a central innate immune‐sensing axis and a promising target for cancer immunotherapy[1-3].Upon sensing cytosolic DNA derived from pathogens,damaged cells,or tumor cells,cGAS catalyzes the production of cyclic dinucleotides(CDNs),which subsequently bind to STING and activate downstream IRF3 and NF‐κB signaling pathways[1,2].This process induces type I interferons and proinflammatory cytokines,thereby linking innate immune activation with adaptive antitumor immunity[3,4].The ability of STING signaling to activate dendritic cells,promote antigen presentation,and stimulate cytotoxic T‐cell responses has made STING agonists attractive candidates for cancer therapy[4,5].Nevertheless,clinical translation has remained difficult.CDN‐based STING agonists usually suffer from rapid enzymatic degradation,poor membrane permeability,short circulation half‐lives,and inefficient tumor accumulation after systemic administration.As a result,many early‐generation STING agonists have relied on intratumoral injection,restricting their use to accessible lesions and limiting their impact on metastatic disease[6]. 展开更多
关键词 type i interferons cancer immunotherapy upon cyclic GMP AMP synthase cyclic gmp amp synthase stimulator cyclic dinucleotides cdns which stimulator interferon genes pathway metal organized nanoassemblies cytosolic dna
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基于IFN-γ/IL-15轴探讨老年急性心肌梗死并发恶性心律失常的机理 认领 引用
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作者 秦杰林 水一方 +1 位作者 陈雅丽 刘闯 《临床医学》 CAS 2026年第7期7-12,共6页
目的基于干扰素-γ(IFN-γ)/白细胞介素-15(IL-15)轴探讨老年急性心肌梗死(AMI)并发恶性心律失常的机理。方法选取2022年12月至2024年10月郑州大学第一附属医院收治的126例老年AMI患者。入院后均检测血清IFN-γ、IL-15水平,根据患者是... 目的基于干扰素-γ(IFN-γ)/白细胞介素-15(IL-15)轴探讨老年急性心肌梗死(AMI)并发恶性心律失常的机理。方法选取2022年12月至2024年10月郑州大学第一附属医院收治的126例老年AMI患者。入院后均检测血清IFN-γ、IL-15水平,根据患者是否并发恶性心律失常,分为失常组与非失常组。比较两组一般资料及血清IFN-γ、IL-15水平,分析血清IFN-γ、IL-15与老年AMI并发恶性心律失常的关系。结果126例老年AMI患者中81例未并发恶性心律失常;45例并发恶性心律失常。失常组前壁梗死、碎裂QRS波占比和白细胞计数、中性粒细胞计数、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、N末端-B型脑钠肽前体(NT-proBNP)、IFN-γ、IL-15水平均高于非失常组(P<0.05),QT间期变异度(QTV)低于非失常组(P<0.05)。多因素Logistic回归分析结果显示,前壁梗死、碎裂QRS波,以及中性粒细胞计数、CK-MB、cTnI、IFN-γ、IL-15高表达均是老年AMI并发恶性心律失常的危险因素(P<0.05),QTV是保护因素(P<0.05)。结论IFN-γ、IL-15水平高表达可增加老年AMI并发恶性心律失常的风险,推测可能与IFN-γ/IL-15轴调控炎症反应、影响心肌电生理活动有关。 展开更多
关键词 急性心肌梗死 恶性心律失常 干扰素-γ 白细胞介素-15
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