Maize yield is critically endangered by diseases throughout its growth cycle,posing significant risks to food security.The spatial and temporal dynamics of maize yield loss and the rate of yield loss attributable to t...Maize yield is critically endangered by diseases throughout its growth cycle,posing significant risks to food security.The spatial and temporal dynamics of maize yield loss and the rate of yield loss attributable to these threats on a regional scale have been challenging to ascertain due to scarce continuous observation data.This study compiled county-level data on maize yield and yield loss across China's six primary cropping regions over twenty years from 1999 to 2018.These include the Spring-sown area of Northern China(1-NC),the Summer-sown Huang-Huai-Hai Plain(2-HHP),the Southwest Mountain(3-SM),the Southern Hilly(4-SH),the Northwest Irrigated(5-NI),and the Qinghai-Tibet Plateau Maize Regions(6-QTP).We identified 15 major diseases affecting these regions.The annual average yield loss due to maize diseases in the regions 1-NC,2-HHP,3-SM,4-SH,5-NI,and 6-QTP were 0.40,0.58,0.12,0.05,0.04 and<0.01 million tons,respectively,and the corresponding average yield loss rate(the ratio of yield loss to total yield)in these regions was 0.63,0.90,0.65,0.63,0.44,and 0.05.The yield loss due to all diseases increased for three regions in 3-SM,4-SH and 5-NI.The yield loss rate due to diseases significantly increased in region 4-SH and 5-NI.Predominantly,maize leaf blight has become the most significant threats.In region 1-NC,maize head smut(D1)and maize leaf blight(D2)were the primary diseases.In region 2-HHP,maize leaf blight(D2),maize rust(D3),maize brown spot(D5),Curvularia leaf spot(D7),and maize virus disease(D14)were the key pathogens.Bivariate trend analysis(joint analysis of yield loss and loss rate trends)indicated that maize head smut(D1)decreased significantly in 1-NC,while in 2-HHP,six diseases showed a significant decrease in both yield loss and loss rate,namely sheath blight(D4),brown spot(D5),root rot(D11),downy mildew(D12)and virus disease(D14).By providing a long-term,national-scale perspective,this study not only supports the development of broad management strategies but also guides the creation of precise,region-specific control protocols to safeguard maize production.展开更多
The lateral transport of labile organic carbon represents a critical pathway for soil organic carbon(SOC) loss,reducing organic carbon sequestration and increasing the risk of waterbody pollution.Livestock manure appl...The lateral transport of labile organic carbon represents a critical pathway for soil organic carbon(SOC) loss,reducing organic carbon sequestration and increasing the risk of waterbody pollution.Livestock manure application on croplands serves as a common fertilizer reduction practice to sustain crop yields,enhance SOC sequestration,and reduce water erosion.However,limited quantitative assessments have examined the effects of livestock manure substitution on labile organic carbon lateral loss and fluxes in long-term experiments.This study conducted a three-year field investigation on subtropical sloping croplands to assess the impact of livestock manure substitution on dissolved organic carbon(DOC) and particulate organic carbon(POC) loss via surface runoff,interflow and eroded sediments.There are four treatments:no fertilization(CK);chemical nitrogen fertilizer(SF),40% nitrogen substitution with pig manure(PMF),and 100% nitrogen substitution from pig manure(PM).Compared to SF treatment,long-term livestock manure substitution in PMF and PM treatments significantly(P<0.05) reduced annual cumulative surface runoff fluxes by 13.5 and 21.6%,respectively.Manure applications decreased annual sediment fluxes by 12.9 and 19.1%,respectively.Soil water stable aggregates for mean weight diameter(MWD) increased significantly by 37.7 and 73.6%.Annual cumulative POC loss flux via eroded sediment under PMF and PM treatments increased significantly(P<0.05) by 61.1 and 47.9%,respectively.The labile organic carbon loss fluxes,including DOC and POC losses,under PMF and PM treatments increased significantly(P<0.05) by 11.9 and 31.4%,respectively.These results demonstrate that while water erosion intensity decreases due to enhanced soil aggregate stability,the risk of labile organic carbon loss increases after long-term livestock manure substitution in subtropical sloping croplands.Future research should examine labile organic carbon lateral migration under various soil types and slope gradients for livestock manure application in subtropical agricultural ecosystem croplands to better understand extreme rainfall effects.展开更多
Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation...Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation contributes to pathological conditions such as osteoporosis,rheumatoid arthritis,and periodontitis.Periodontitis is a highly prevalent chronic inflammatory disease driven by dysbiotic biofilms that disrupt the oral microbiome,leading to the progressive breakdown of the periodontal ligament,cementum,and alveolar bone and ultimately resulting in tooth loss.This review outlines the molecular and cellular mechanisms underlying periodontitis,focusing on osteoclastogenesis,the differentiation and activation of osteoclasts,the primary mediators of bone resorption.Key transcriptional regulators,including NFATc1,c-Fos,and c-Src are discussed alongside major signaling pathways such as Mitogen Activated Protein Kinase(MAPK),Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription(JAK/STAT),Nuclear Factor Kappa B(NF-κB),and Phosphoinositide 3-kinase(PI3K)/Akt,to elucidate their roles in the initiation and progression of periodontal bone loss.These pathways orchestrate the inflammatory response and osteoclast activity,underscoring their relevance in periodontitis and other osteolytic conditions.Hallmark features of periodontitis,including chronic inflammation,immune dysregulation,and tissue destruction are highlighted,with emphasis on current and emerging therapeutic strategies targeting these molecular pathways.Special attention is given to small molecules,biologics,and natural compounds that have the potential to modulate key signaling pathways.Although advances in understanding these mechanisms have identified promising therapeutic targets,translation into effective clinical interventions remains challenging.Continued research into regulating bone-resorptive signaling pathways is essential for developing more effective treatments for periodontitis and related inflammatory bone diseases.展开更多
The emerging connection:As populations age,the link between age-related hearing loss(ARHL)and Alzheimer's disease(AD) is emerging as one of the most urgent public health challenges of our time.Recent research anal...The emerging connection:As populations age,the link between age-related hearing loss(ARHL)and Alzheimer's disease(AD) is emerging as one of the most urgent public health challenges of our time.Recent research analyzing 2946 communitydwelling adults revealed that hearing loss may contribute to nearly one-third of all new dementia cases—significantly higher than previous estimates(Ishak et al.,2025).This epidemiological evidence suggests a mechanistic rather than coincidental relationship.Longitudinal studies show hearing loss precedes cognitive decline by5-10 years.The implications are demographically profound.The yearly costs related to dementia are over $1.3 trillion,and untreated hearing loss adds another $133 billion in lost productivity.展开更多
Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genet...Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genetic abnormalities,infectious diseases,uterine anomalies,sperm DNA fragmentation,and epigenetics.Among genetic causes,chromosomal abnormalities are the most frequent etiological factor of early miscarriage,accounting for 50%–60%of first trimester abortions.Numerical or structural chromosomal changes may result in spontaneous miscarriages.These anomalies arise as a result of chromosomal translocation,non-disjunction,or mutations[1].Transmission of parental chromosomal abnormalities may be one of the chances for a recurrence of miscarriage in the first trimester of pregnancy,albeit the cause is unknown[2,3].展开更多
Global crises like climate change and food insecurity demand sustainable food systems.A major contributor to these issues is food loss and waste(FLW),which generates greenhouse gases,worsens hunger,and causes massive ...Global crises like climate change and food insecurity demand sustainable food systems.A major contributor to these issues is food loss and waste(FLW),which generates greenhouse gases,worsens hunger,and causes massive economic loss.High-Pressure Processing(HPP)is a promising non-thermal technology that can address this problem.This review explores how HPP contributes towards reducing food waste and its environmental footprint,aligning with the principles of Carbon-Winnable Innovative Solutions for the Environment(WISE)agriculture.By using high pressure instead of heat,HPP extends product shelf-life,reduces the need for chemical additives,and maintains food quality.We evaluate its environmental benefits,including lower energy use compared to traditional thermal methods,and its role in creating a more circular,low-carbon food economy.The article specifically analyses the adoption of HPP in ASEAN(Association of Southeast Asian Nations)countries.While nations such as Singapore,Thailand,Malaysia,and Indonesia have begun using HPP,its wider adoption remains limited due to the high initial costs.We highlight the opportunities and challenges for expanding HPP in the region,considering local markets and regulatory frameworks.Collectively,this review highlights that HPP is a key strategy for improving food security by reducing waste sustainably,directly supporting the goals of Carbon-WISE agriculture in ASEAN.展开更多
With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challe...With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.展开更多
Thermal energy systems(TES)are an essential part of industries that have evolved over time through the engagement of managers and researchers.The development of digital twin(DT)technology has enabled accurate predicti...Thermal energy systems(TES)are an essential part of industries that have evolved over time through the engagement of managers and researchers.The development of digital twin(DT)technology has enabled accurate prediction of their performance.The inherent limitations of complex thermal systems,such as noisy input data and occasional lack of measurement data or boundary conditions,have recently created opportunities to apply physics-based problem-solving alongside DT technology.This paper aims to systematically review the novel physics-informed neural network-digital twin(PINN-DT)methodology as a potential solution to these challenges,and to present a taxonomy for problem-solving.The outcome of this study provides valuable guidance in selecting PINN-DT technology in thermal energy system(TES)modeling.A review of the proposed loss functions demonstrates that their design is critical for achieving precise outcomes in this technology,effectively serving as the foundational core of PINN-DT.As a result,it is recommended that the construction of the loss function be fundamentally guided by two principal considerations:forecasting accuracy and compliance with physical principles,which serve as foundational pillars in the surrogate model design framework.A significant gap exists in applying this technology to industries that use discrete sampling for quality control.Implementing the PINN-DT framework could address this issue by determining optimal sampling intervals,thereby offering vital decision-making support.Moreover,the absence of exergy analysis in formulating the physical loss component of the loss function represents a significant research gap.Future studies should therefore incorporate the exergy concept into the design of the loss function.展开更多
Sensorineural hearing loss(SNHL)is a prevalent global health issue,primarily caused by excessive generation of reactive oxygen species(ROs)due to acoustic trauma,aging,and ototoxic drugs.Naturalantioxidant enzymes,suc...Sensorineural hearing loss(SNHL)is a prevalent global health issue,primarily caused by excessive generation of reactive oxygen species(ROs)due to acoustic trauma,aging,and ototoxic drugs.Naturalantioxidant enzymes,such as catalase(CAT),possess remarkable ROS scavenging capabilities and hold significant potential for SNHL treatment.However,their clinical application is hindered byinefficient delivery and limited stability.Here,we introduce a novel peptide-oligosaccharide conjugate,sELP-ON,which forms coacervate microdroplets via liquid-liquid phase separation.These microdroplets efficiently encapsulate and stably carry CAT,releasing it in a glutathione-triggered,redox-responsive manner.The CATloaded sELP-ON(sELP-ON@CAT)enhanced cellular uptake through direct cytoplasmic internalization and demonstrates a more robust ROS scavenging activity than naked CAT treatment.Local administration of sELP-ON@CAT in an acoustic injury mouse model effectively rescues hearing loss by reducing cochlear ROS levels,thereby mitigating hair cell loss,ribbon synapse depletion,stria vascularis shrinkage and spiral ganglion neuron degeneration.In summary,our innovative coacervate microdroplet system enables targeted,redox-responsive cytoplasmic delivery of macromolecular antioxidants,offering a novel and effective strategy for treating SNHL.展开更多
Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte ...Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte engineering currently relies on conventional evaluation criteria of reducing coulombic consumption,which implicitly presume its equivalence to irreversible capacity loss and complicates battery development.We introduce the detrimental ratioρto quantify the fraction of parasitic species that permanently degrades active material.This metric is independent and crucially complements total coulombic consumption for accurate performance evaluation.We systematically investigate multiple electrolyte formulations using high-precision leakage current measurements,open-circuit-voltage experiments,and post-mortem characterizations.Although some electrolytes exhibit similarly low coulombic consumption,they diverge significantly in capacity retention andρ.Especially,dimethyl-carbonate-based localized-high concentration electrolyte can synergically achieve low coulombic consumption and detrimental ratioρduring calendar aging,owing to its chemically inert and structurally resilient solidelectrolyte interface with minimal isolated Si material.By contrast,increasing fluoroethylene carbonate(FEC)additive content suppresses electrolyte breakdown but suffers aggravated chemical degradation of more LixSi isolation for irreversible capacity loss with a risingρ.This study critically reveals that the chemistry-characteristic detrimental ratioρestablishes physically informed performance evaluation to pave the way for accelerating battery development.展开更多
Anaerobic ammonium oxidation(anammox)plays a vital role in the global nitrogen cycle by mitigating reactive nitrogen.In recent years,its ecological importance has drawn increasing attention.Despite its widespread occu...Anaerobic ammonium oxidation(anammox)plays a vital role in the global nitrogen cycle by mitigating reactive nitrogen.In recent years,its ecological importance has drawn increasing attention.Despite its widespread occurrence,the distribution and quantitative contribution of anammox to global nitrogen loss remain unclear.We collected 390 reported anammox activity measurements which were obtained using 15N isotope tracing techniques and analyzed anammox rate and environmental factors including soil/sediment and water property using generalized additive models(GAMs).Moreover,based on the division of the anammox activity region,we estimated anammox-driven nitrogen loss across different ecosystems including wetlands and oxygen minimum zones(OMZs)ecosystems.Our findings revealed that soil moisture content was the most significant predictor of anammox activity in wetlands ecosystems.Paddy fields contributed 51%of anammox-driven nitrogen loss(32.0 Tg N/yr),followed by rivers/lakes(29%)and wetlands(20%).Asia emerged as the dominant region for anammoxdriven nitrogen loss(30.7 Tg N/yr),with paddy fields making a substantial contribution.North America was the second-largest contributor(25.4 Tg N/yr),with rivers/lakes being the main sources of nitrogen loss.In OMZs ecosystems,nitrate and dissolved oxygen were key factors influencing anammox rates.OMZs were hotspots for anammox,with peak activity at 300 m depth and nitrogen loss totaling 68.6 Tg N/yr,mostly between 100 and 500 m depths.This study underscores the critical role of anammox in global nitrogen cycling and offers a basis for environmental nitrogen management through predictive anammox modeling.展开更多
The rapid advancement of 6G communication has drawn significant attention to non-terrestrial networks(NTN),where accurate modeling of clutter loss(CL)is essential for efficient deployment and system optimization.This ...The rapid advancement of 6G communication has drawn significant attention to non-terrestrial networks(NTN),where accurate modeling of clutter loss(CL)is essential for efficient deployment and system optimization.This paper conducts multi-band channel measurements at 6.5 GHz,10.2 GHz,11.8 GHz,and 14.2 GHz to investigate the frequency and elevation angle dependencies of CL.To address the limited physical interpretability of existing standard models,a semi-deterministic approach is proposed based on the single knife-edge diffraction theory.The modeling results and analysis show that the proposed model has lower prediction errors than the standard model in complex environments with building and vegetation obstructions,with a simple formula that effectively captures the variations in CL with frequency and elevation angle.This contributes valuable insights for the design and implementation of NTN communication systems.展开更多
Electromagnetic wave absorption materials require high dielectric loss and excellent impedance matching performance.However,current conventional biomass‐derived electromagnetic wave absorption materials are still lim...Electromagnetic wave absorption materials require high dielectric loss and excellent impedance matching performance.However,current conventional biomass‐derived electromagnetic wave absorption materials are still limited by low electrical conductivity and a single structure.In this work,a“sphereetwork”hierarchical attenuation electromagnetic wave absorption material,which combines weakly conductive biomass‐derived carbon spheres and highly conductive cantaloupe‐like textured polypyrrole,was synthesized using Fe3+and methyl orange as template‐directing agents.Under the guiding effect of methyl orange,polypyrrole does not undergo disordered agglomeration on the surface of carbon spheres;instead,tubular polypyrrole grows orderly along the sphere surface and assembles to form a continuous conductive network.Conduction loss,dipole polarization,and interfacial polarization loss-acting as cooperative loss mechanisms-enable OJ‐MO‐PPy‐2.5 to achieve broadband effective absorption,with an effective absorption bandwidth of 7.2 GHz and a minimum reflection loss of−48.82 dB.Meanwhile,computer simulation technology(CST)simulation results indicate that after coating OJ‐MO‐PPy‐2.5,the reflection intensity of the electromagnetic wave is reduced by approximately three times when the wave is incident normally.The successful fabrication of OJ‐MO‐PPy furnishes novel insights for biomass‐derived electromagnetic wave absorption materials with broadband absorption capabilities.展开更多
Understanding the evaporative loss of shale oil is critical for the shale oil resources assessment.However,previous studies have largely neglected the rapid evaporative loss of shale oil that occurs immediately after ...Understanding the evaporative loss of shale oil is critical for the shale oil resources assessment.However,previous studies have largely neglected the rapid evaporative loss of shale oil that occurs immediately after drill cores are retrieved to the surface at the well site.Thus,the factors influencing the evaporative loss of shale oil during thermal evolution remain inadequately explored.In this study,closed-system pyrolysis experiments were carried out to the artificially mature Qingshankou Formation shales.Subsequently,low-field nuclear magnetic resonance(LF-NMR)techniques were utilized to monitor the variations in oil content of the shales under different exposure times.Our experimental approach successfully reconstructed the entire evaporative loss process of shale oil,spanning from its original subsurface location to the well site,from the well site to the laboratory,and ultimately to long-term core storage.We find that the maximum loss of shale oil reaches approximately 10%within the first 10 h following the retrieval of drill cores from the subsurface to the ground,followed by a gradual deceleration,and the maximum loss ranges from 11%to 89%.As thermal maturity increases to a range of Ro=0.89%–1.20%,the loss proportion of shale oil shows a decreasing trend,which can be attributed to the reduction in total organic carbon(TOC)content.It is worth mentioning that the loss proportion of shale oil exhibits a continuous increasing trend at the thermal range of 1.20%–1.75%.At this stage,the hydrocarbon composition(C6–C14/C15+ratio)may be the mainly controlling factors for the shale oil loss proportion,while TOC content and nanopore volume serve as secondary factors.Our analyses reveal that hydrocarbon evaporative loss of shale oil is complex and involves various factors,especially the first 10 h during the transfer of the shale from its in-situ reservoir to the surface at the well site,which is critical to the understanding of shale oil occurrence and accurate resource assessment.展开更多
The increasing overall pressure ratio of aero-engines has led to considerable windage losses in the Rear Drum Cavity(RDC)of the secondary air system.These losses convert turbine power into thermal energy,resulting in ...The increasing overall pressure ratio of aero-engines has led to considerable windage losses in the Rear Drum Cavity(RDC)of the secondary air system.These losses convert turbine power into thermal energy,resulting in both energy consumption and a reduction in the rotor's operational lifetime.To expand the experimental database to engine-representative nondimensional conditions,a comprehensive experimental study was conducted,with the mass flow coefficient Cwranging from 3.54×104to 7.59×104and the rotational Reynolds number Reφranging from 3.31×106to 1.02×107.The effects of Cwand Reφon windage characteristics and swirl ratio distribution are analyzed.Furthermore,a theoretical model incorporating core swirl ratio modification and an empirical model are derived to predict windage losses.The experimental results indicate that windage losses are intensified by increasing Cwand Reф,leading to a maximum power consumption of 8 kW and a temperature rise of 54.6 K.Significant windage losses are predominantly driven by a weakened swirl ratio,which arises from the disturbance induced by the stator-mounted bolts.Particularly in the rear region of the RDC,the swirl ratio declines monotonically along the radial direction,showing minimal variation across all operating conditions,while the core swirl ratio remains consistently low,at approximately 0.2.Compared to the experimental data,the theoretical model exhibits an average error of 11%and the empirical model achieves a lower average error of 3%.These findings hold significant implications for enhancing the performance analysis of aero-engines.展开更多
Fe-based nanocrystalline powders are ideal soft magnetic materials for matching the wide bandgap semiconductors.Previously developed Fe-based nanocrystalline alloys are difficult to produce high-quality precursor powd...Fe-based nanocrystalline powders are ideal soft magnetic materials for matching the wide bandgap semiconductors.Previously developed Fe-based nanocrystalline alloys are difficult to produce high-quality precursor powder by gas atomization due to their poor amorphous forming ability,and their following nanocrystallizations also require high temperatures or heating rates.In present work,we invented novel high-performance Fe-based nanocrystalline powders that can be directly manufactured by gas atomization without annealing.The as-atomized Fe73.3Si12B13Cu1.7nanocrystalline powders exhibit fine α-Fe(Si)crystals with an average size of 15.1 nm and high saturation magnetization(Ms)of 156.2 emu/g.The Fe73.3Si12B13Cu1.7soft magnetic powder cores annealed at 480℃for 60 min process high effective permeability of 35.9 and low core losses(50 mT/100 kHz)of 310.1 mW/cm3.These outstanding magnetic properties and good processability make the developed Fe73.3Si12B13Cu1.7nanocrystalline powders highly promising for high-performance inductors and transformers.展开更多
Correction to:Nuclear Science and Techniques(2025)36:111 http://gffzzd3cc09b8251d45dfspuo5v9v9wu0b6kvn.ffgz.tsg.suse.edu.cn/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have ...Correction to:Nuclear Science and Techniques(2025)36:111 http://gffzzd3cc09b8251d45dfspuo5v9v9wu0b6kvn.ffgz.tsg.suse.edu.cn/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have read‘SCRs’.In Table 7 of this article,the column header ρ_fuel was incorrect and should have read CPv_fuel.For completeness and transparency,the old incorrect version and the corrected version of Table 7 are displayed below.展开更多
Amphibious vehicles are more prone to attitude instability compared to ships,making it crucial to develop effective methods for monitoring instability risks.However,large inclination events,which can lead to instabili...Amphibious vehicles are more prone to attitude instability compared to ships,making it crucial to develop effective methods for monitoring instability risks.However,large inclination events,which can lead to instability,occur frequently in both experimental and operational data.This infrequency causes events to be overlooked by existing prediction models,which lack the precision to accurately predict inclination attitudes in amphibious vehicles.To address this gap in predicting attitudes near extreme inclination points,this study introduces a novel loss function,termed generalized extreme value loss.Subsequently,a deep learning model for improved waterborne attitude prediction,termed iInformer,was developed using a Transformer-based approach.During the embedding phase,a text prototype is created based on the vehicle’s operation log data is constructed to help the model better understand the vehicle’s operating environment.Data segmentation techniques are used to highlight local data variation features.Furthermore,to mitigate issues related to poor convergence and slow training speeds caused by the extreme value loss function,a teacher forcing mechanism is integrated into the model,enhancing its convergence capabilities.Experimental results validate the effectiveness of the proposed method,demonstrating its ability to handle data imbalance challenges.Specifically,the model achieves over a 60%improvement in root mean square error under extreme value conditions,with significant improvements observed across additional metrics.展开更多
Description of the correction:The authors wish to make the following corrections to improve clarity and ensure appropriate attribution of related prior work.These corrections do not affect the results,analyses,or conc...Description of the correction:The authors wish to make the following corrections to improve clarity and ensure appropriate attribution of related prior work.These corrections do not affect the results,analyses,or conclusions of the original article.1.Addition of relevant prior work in the Introduction section:After the sentence:“Schroff et al.[15]developed a triplet-based loss function for this problem to help the model go to a better learning representation,achieving better results and new record accuracy on multiple datasets.”The following text should be added:“Shen et al.[37,38]first proposed activity-cliff awareness loss and ACANet,which explicitly defined activity-cliff triplets based on activity differences and extended the triplet loss framework to regression tasks by adaptively adjusting the margin.In their formulation,the margin is dynamically modulated to pull samples closer or push them farther apart according to their label differences,enabling effective awareness of activity cliffs in molecular activity prediction.”展开更多
Background:Stem cell therapy offers promise for the neurodegenerative diseases and has been explored for sensorineural hearing loss(SNHL).However,effective cell delivery strategies remain a critical challenge for SNHL...Background:Stem cell therapy offers promise for the neurodegenerative diseases and has been explored for sensorineural hearing loss(SNHL).However,effective cell delivery strategies remain a critical challenge for SNHL treatment.Methods:To address this need,we established an ouabain-induced SGN injured hearing loss model in rat and evaluated a novel transplantation strategy targeting the cochlear nerve surface via posterior occipital approach,designed to minimize cochlear structural damage and facilitate targeted cell delivery to Rosenthal's canal(RC).The temporal changes in glial cell densities within RC revealed a progressively deteriorating neural microenvironment,supporting early-stage intervention.Accordingly,hair follicle-derived neural crest stem cell(HFNCSC)transplantation was performed 3 or 4 days after modeling via two approaches:cochlear nerve surface transplantation(CNT)and round window transplantation(RWT).Results:CNT resulted in significant improvements in auditory function,as evidenced by reduced auditory brainstem response(ABR)thresholds,shortened waveⅠlatencies,and preserved waveⅠamplitudes post-transplantation.Transplanted cells were distributed along the nerve trunk and within RC.In contrast,RWT failed to improve auditory function and caused cochlear structural damage,with widespread cell dispersion in cochlear fluids.Notably,the CNT group exhibited significantly higher densities of TUJ1-positive neuron-like cells and glial cells in the RC,accompanied by enhanced myelin basic protein expression suggestive of remyelination.No such improvements were observed in the RWT group.Conclusions:These findings suggest that cochlear nerve surface transplantation enhances stem cell survival and auditory function recovery,and represents a promising delivery approach for stem cell-based therapy of SGN-related hearing loss.展开更多
基金supported by the National Key Research and Development Program of China,China(2022YFF1301801)Agricultural scientific and technological innovation project of Shandong Academy of Agricultural Sciences,China(333 Project)(06202214442066)+1 种基金Beijing Natural Science Foundation,China(5232018)Technology Innovation Project of Shandong Academy of Agricultural Sciences,China(06202214442062).
摘要Maize yield is critically endangered by diseases throughout its growth cycle,posing significant risks to food security.The spatial and temporal dynamics of maize yield loss and the rate of yield loss attributable to these threats on a regional scale have been challenging to ascertain due to scarce continuous observation data.This study compiled county-level data on maize yield and yield loss across China's six primary cropping regions over twenty years from 1999 to 2018.These include the Spring-sown area of Northern China(1-NC),the Summer-sown Huang-Huai-Hai Plain(2-HHP),the Southwest Mountain(3-SM),the Southern Hilly(4-SH),the Northwest Irrigated(5-NI),and the Qinghai-Tibet Plateau Maize Regions(6-QTP).We identified 15 major diseases affecting these regions.The annual average yield loss due to maize diseases in the regions 1-NC,2-HHP,3-SM,4-SH,5-NI,and 6-QTP were 0.40,0.58,0.12,0.05,0.04 and<0.01 million tons,respectively,and the corresponding average yield loss rate(the ratio of yield loss to total yield)in these regions was 0.63,0.90,0.65,0.63,0.44,and 0.05.The yield loss due to all diseases increased for three regions in 3-SM,4-SH and 5-NI.The yield loss rate due to diseases significantly increased in region 4-SH and 5-NI.Predominantly,maize leaf blight has become the most significant threats.In region 1-NC,maize head smut(D1)and maize leaf blight(D2)were the primary diseases.In region 2-HHP,maize leaf blight(D2),maize rust(D3),maize brown spot(D5),Curvularia leaf spot(D7),and maize virus disease(D14)were the key pathogens.Bivariate trend analysis(joint analysis of yield loss and loss rate trends)indicated that maize head smut(D1)decreased significantly in 1-NC,while in 2-HHP,six diseases showed a significant decrease in both yield loss and loss rate,namely sheath blight(D4),brown spot(D5),root rot(D11),downy mildew(D12)and virus disease(D14).By providing a long-term,national-scale perspective,this study not only supports the development of broad management strategies but also guides the creation of precise,region-specific control protocols to safeguard maize production.
基金funded by the Joint Funds of the National Natural Science Foundation of China (U20A20107 and U22A20562)the National Key Research and Development Program of China (2023YFD1900201-3)the International Cooperation Project,Ministry of Science and Technology of China (G2023019005L)。
摘要The lateral transport of labile organic carbon represents a critical pathway for soil organic carbon(SOC) loss,reducing organic carbon sequestration and increasing the risk of waterbody pollution.Livestock manure application on croplands serves as a common fertilizer reduction practice to sustain crop yields,enhance SOC sequestration,and reduce water erosion.However,limited quantitative assessments have examined the effects of livestock manure substitution on labile organic carbon lateral loss and fluxes in long-term experiments.This study conducted a three-year field investigation on subtropical sloping croplands to assess the impact of livestock manure substitution on dissolved organic carbon(DOC) and particulate organic carbon(POC) loss via surface runoff,interflow and eroded sediments.There are four treatments:no fertilization(CK);chemical nitrogen fertilizer(SF),40% nitrogen substitution with pig manure(PMF),and 100% nitrogen substitution from pig manure(PM).Compared to SF treatment,long-term livestock manure substitution in PMF and PM treatments significantly(P<0.05) reduced annual cumulative surface runoff fluxes by 13.5 and 21.6%,respectively.Manure applications decreased annual sediment fluxes by 12.9 and 19.1%,respectively.Soil water stable aggregates for mean weight diameter(MWD) increased significantly by 37.7 and 73.6%.Annual cumulative POC loss flux via eroded sediment under PMF and PM treatments increased significantly(P<0.05) by 61.1 and 47.9%,respectively.The labile organic carbon loss fluxes,including DOC and POC losses,under PMF and PM treatments increased significantly(P<0.05) by 11.9 and 31.4%,respectively.These results demonstrate that while water erosion intensity decreases due to enhanced soil aggregate stability,the risk of labile organic carbon loss increases after long-term livestock manure substitution in subtropical sloping croplands.Future research should examine labile organic carbon lateral migration under various soil types and slope gradients for livestock manure application in subtropical agricultural ecosystem croplands to better understand extreme rainfall effects.
基金supported by grant provided by the Sao Paulo Research Foundation-FAPESP.Grant#2023/15750-7。
摘要Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation contributes to pathological conditions such as osteoporosis,rheumatoid arthritis,and periodontitis.Periodontitis is a highly prevalent chronic inflammatory disease driven by dysbiotic biofilms that disrupt the oral microbiome,leading to the progressive breakdown of the periodontal ligament,cementum,and alveolar bone and ultimately resulting in tooth loss.This review outlines the molecular and cellular mechanisms underlying periodontitis,focusing on osteoclastogenesis,the differentiation and activation of osteoclasts,the primary mediators of bone resorption.Key transcriptional regulators,including NFATc1,c-Fos,and c-Src are discussed alongside major signaling pathways such as Mitogen Activated Protein Kinase(MAPK),Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription(JAK/STAT),Nuclear Factor Kappa B(NF-κB),and Phosphoinositide 3-kinase(PI3K)/Akt,to elucidate their roles in the initiation and progression of periodontal bone loss.These pathways orchestrate the inflammatory response and osteoclast activity,underscoring their relevance in periodontitis and other osteolytic conditions.Hallmark features of periodontitis,including chronic inflammation,immune dysregulation,and tissue destruction are highlighted,with emphasis on current and emerging therapeutic strategies targeting these molecular pathways.Special attention is given to small molecules,biologics,and natural compounds that have the potential to modulate key signaling pathways.Although advances in understanding these mechanisms have identified promising therapeutic targets,translation into effective clinical interventions remains challenging.Continued research into regulating bone-resorptive signaling pathways is essential for developing more effective treatments for periodontitis and related inflammatory bone diseases.
摘要The emerging connection:As populations age,the link between age-related hearing loss(ARHL)and Alzheimer's disease(AD) is emerging as one of the most urgent public health challenges of our time.Recent research analyzing 2946 communitydwelling adults revealed that hearing loss may contribute to nearly one-third of all new dementia cases—significantly higher than previous estimates(Ishak et al.,2025).This epidemiological evidence suggests a mechanistic rather than coincidental relationship.Longitudinal studies show hearing loss precedes cognitive decline by5-10 years.The implications are demographically profound.The yearly costs related to dementia are over $1.3 trillion,and untreated hearing loss adds another $133 billion in lost productivity.
摘要Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genetic abnormalities,infectious diseases,uterine anomalies,sperm DNA fragmentation,and epigenetics.Among genetic causes,chromosomal abnormalities are the most frequent etiological factor of early miscarriage,accounting for 50%–60%of first trimester abortions.Numerical or structural chromosomal changes may result in spontaneous miscarriages.These anomalies arise as a result of chromosomal translocation,non-disjunction,or mutations[1].Transmission of parental chromosomal abnormalities may be one of the chances for a recurrence of miscarriage in the first trimester of pregnancy,albeit the cause is unknown[2,3].
基金funded by the Southeast Asian Regional Center for Graduate Study and Research in Agriculture(SEARCA)through the Regional Professorial Chair Award for Academic Year 2025-2026。
摘要Global crises like climate change and food insecurity demand sustainable food systems.A major contributor to these issues is food loss and waste(FLW),which generates greenhouse gases,worsens hunger,and causes massive economic loss.High-Pressure Processing(HPP)is a promising non-thermal technology that can address this problem.This review explores how HPP contributes towards reducing food waste and its environmental footprint,aligning with the principles of Carbon-Winnable Innovative Solutions for the Environment(WISE)agriculture.By using high pressure instead of heat,HPP extends product shelf-life,reduces the need for chemical additives,and maintains food quality.We evaluate its environmental benefits,including lower energy use compared to traditional thermal methods,and its role in creating a more circular,low-carbon food economy.The article specifically analyses the adoption of HPP in ASEAN(Association of Southeast Asian Nations)countries.While nations such as Singapore,Thailand,Malaysia,and Indonesia have begun using HPP,its wider adoption remains limited due to the high initial costs.We highlight the opportunities and challenges for expanding HPP in the region,considering local markets and regulatory frameworks.Collectively,this review highlights that HPP is a key strategy for improving food security by reducing waste sustainably,directly supporting the goals of Carbon-WISE agriculture in ASEAN.
基金supported by the Science and Technology Development Project of Jilin Province(Project No.YDZJ202301ZYTS284).
摘要With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.
摘要Thermal energy systems(TES)are an essential part of industries that have evolved over time through the engagement of managers and researchers.The development of digital twin(DT)technology has enabled accurate prediction of their performance.The inherent limitations of complex thermal systems,such as noisy input data and occasional lack of measurement data or boundary conditions,have recently created opportunities to apply physics-based problem-solving alongside DT technology.This paper aims to systematically review the novel physics-informed neural network-digital twin(PINN-DT)methodology as a potential solution to these challenges,and to present a taxonomy for problem-solving.The outcome of this study provides valuable guidance in selecting PINN-DT technology in thermal energy system(TES)modeling.A review of the proposed loss functions demonstrates that their design is critical for achieving precise outcomes in this technology,effectively serving as the foundational core of PINN-DT.As a result,it is recommended that the construction of the loss function be fundamentally guided by two principal considerations:forecasting accuracy and compliance with physical principles,which serve as foundational pillars in the surrogate model design framework.A significant gap exists in applying this technology to industries that use discrete sampling for quality control.Implementing the PINN-DT framework could address this issue by determining optimal sampling intervals,thereby offering vital decision-making support.Moreover,the absence of exergy analysis in formulating the physical loss component of the loss function represents a significant research gap.Future studies should therefore incorporate the exergy concept into the design of the loss function.
基金supported by grants from National Key R&D Program of China(Nos.2024YFC2511100 and 2024YFC2511105 to J.Yang)National Natural Science Foundation of China(Nos.82230035 and 82271179 to J.Yang,82000977 and 82371150 to S.Hou,82000989 to P.Chen)Shanghai SailingProgram(Nos.20YF1428800 to P.Chen,20YF1428900 to S.Hou).
摘要Sensorineural hearing loss(SNHL)is a prevalent global health issue,primarily caused by excessive generation of reactive oxygen species(ROs)due to acoustic trauma,aging,and ototoxic drugs.Naturalantioxidant enzymes,such as catalase(CAT),possess remarkable ROS scavenging capabilities and hold significant potential for SNHL treatment.However,their clinical application is hindered byinefficient delivery and limited stability.Here,we introduce a novel peptide-oligosaccharide conjugate,sELP-ON,which forms coacervate microdroplets via liquid-liquid phase separation.These microdroplets efficiently encapsulate and stably carry CAT,releasing it in a glutathione-triggered,redox-responsive manner.The CATloaded sELP-ON(sELP-ON@CAT)enhanced cellular uptake through direct cytoplasmic internalization and demonstrates a more robust ROS scavenging activity than naked CAT treatment.Local administration of sELP-ON@CAT in an acoustic injury mouse model effectively rescues hearing loss by reducing cochlear ROS levels,thereby mitigating hair cell loss,ribbon synapse depletion,stria vascularis shrinkage and spiral ganglion neuron degeneration.In summary,our innovative coacervate microdroplet system enables targeted,redox-responsive cytoplasmic delivery of macromolecular antioxidants,offering a novel and effective strategy for treating SNHL.
基金supported by the U.S.Department of Energy(DOE),Office of Energy Efficiency and Renewable Energy(EERE),Vehicle Technologies Office(VTO)under the Silicon Consortium Seedling project received by Z.H.Coperated for the DOE Office of Science by UChicago Argonne,LLC,under Contract DE-AC02-06CH11357+2 种基金Pacific Northwest National Laboratory(PNNL)was supported by the U.S.DOE,Office of Advanced Research Projects Agency-Energy(ARPA-E)under the EVs4ALL Program with the contract number DE-AC05-76RL01830operated by Battelle for the DOE under Contract DE-AC0576RL01830performed at the Oak Ridge National Laboratory(GMV)and supported by U.S.DOE’s VTO under the Silicon Consortium Program received by G.M.V.and directed by Carine Steinway,Nicolas Eidson Thomas,Thomas Do。
摘要Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte engineering currently relies on conventional evaluation criteria of reducing coulombic consumption,which implicitly presume its equivalence to irreversible capacity loss and complicates battery development.We introduce the detrimental ratioρto quantify the fraction of parasitic species that permanently degrades active material.This metric is independent and crucially complements total coulombic consumption for accurate performance evaluation.We systematically investigate multiple electrolyte formulations using high-precision leakage current measurements,open-circuit-voltage experiments,and post-mortem characterizations.Although some electrolytes exhibit similarly low coulombic consumption,they diverge significantly in capacity retention andρ.Especially,dimethyl-carbonate-based localized-high concentration electrolyte can synergically achieve low coulombic consumption and detrimental ratioρduring calendar aging,owing to its chemically inert and structurally resilient solidelectrolyte interface with minimal isolated Si material.By contrast,increasing fluoroethylene carbonate(FEC)additive content suppresses electrolyte breakdown but suffers aggravated chemical degradation of more LixSi isolation for irreversible capacity loss with a risingρ.This study critically reveals that the chemistry-characteristic detrimental ratioρestablishes physically informed performance evaluation to pave the way for accelerating battery development.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750400)the National Natural Science Foundation of China(Nos.91851204,42177063,and 52370185)+1 种基金the Special project of eco-environmental technology for peak carbon dioxide emissions and carbon neutrality(No.RCEES-TDZ-2021-20)the State Key Joint Laboratory of Environmental Simulation and Pollution Control(Research Center for Eco-environmental Sciences,Chinese Academy of Sciences)(No.24Z01ESPCR).
摘要Anaerobic ammonium oxidation(anammox)plays a vital role in the global nitrogen cycle by mitigating reactive nitrogen.In recent years,its ecological importance has drawn increasing attention.Despite its widespread occurrence,the distribution and quantitative contribution of anammox to global nitrogen loss remain unclear.We collected 390 reported anammox activity measurements which were obtained using 15N isotope tracing techniques and analyzed anammox rate and environmental factors including soil/sediment and water property using generalized additive models(GAMs).Moreover,based on the division of the anammox activity region,we estimated anammox-driven nitrogen loss across different ecosystems including wetlands and oxygen minimum zones(OMZs)ecosystems.Our findings revealed that soil moisture content was the most significant predictor of anammox activity in wetlands ecosystems.Paddy fields contributed 51%of anammox-driven nitrogen loss(32.0 Tg N/yr),followed by rivers/lakes(29%)and wetlands(20%).Asia emerged as the dominant region for anammoxdriven nitrogen loss(30.7 Tg N/yr),with paddy fields making a substantial contribution.North America was the second-largest contributor(25.4 Tg N/yr),with rivers/lakes being the main sources of nitrogen loss.In OMZs ecosystems,nitrate and dissolved oxygen were key factors influencing anammox rates.OMZs were hotspots for anammox,with peak activity at 300 m depth and nitrogen loss totaling 68.6 Tg N/yr,mostly between 100 and 500 m depths.This study underscores the critical role of anammox in global nitrogen cycling and offers a basis for environmental nitrogen management through predictive anammox modeling.
基金supported by the National Natural Science Foundation of China(No.62341128)National Natural Science Foundation of China under Grant 62525101,National Natural Science Foundation of China(No.62571059)+1 种基金Natural Science Foundation of Beijing-Xiaomi Innovation Joint Foundation(L243002)Beijing University of Posts and Telecommunications China Mobile Research Institute Joint Innovation Institute.
摘要The rapid advancement of 6G communication has drawn significant attention to non-terrestrial networks(NTN),where accurate modeling of clutter loss(CL)is essential for efficient deployment and system optimization.This paper conducts multi-band channel measurements at 6.5 GHz,10.2 GHz,11.8 GHz,and 14.2 GHz to investigate the frequency and elevation angle dependencies of CL.To address the limited physical interpretability of existing standard models,a semi-deterministic approach is proposed based on the single knife-edge diffraction theory.The modeling results and analysis show that the proposed model has lower prediction errors than the standard model in complex environments with building and vegetation obstructions,with a simple formula that effectively captures the variations in CL with frequency and elevation angle.This contributes valuable insights for the design and implementation of NTN communication systems.
基金financially supported by the project of the Key‐Area Research and Development Program of Dongguan(Grant No.20241201300022)the Advanced Materials‐National Science and Technology Major Project(Grant No.2025ZD0619202)the Natural Science Foundation Project of Chongqing Research Institute,Harbin Institute of Technology(Grant No.CSTB2022NSCQ‐MSX1572).
摘要Electromagnetic wave absorption materials require high dielectric loss and excellent impedance matching performance.However,current conventional biomass‐derived electromagnetic wave absorption materials are still limited by low electrical conductivity and a single structure.In this work,a“sphereetwork”hierarchical attenuation electromagnetic wave absorption material,which combines weakly conductive biomass‐derived carbon spheres and highly conductive cantaloupe‐like textured polypyrrole,was synthesized using Fe3+and methyl orange as template‐directing agents.Under the guiding effect of methyl orange,polypyrrole does not undergo disordered agglomeration on the surface of carbon spheres;instead,tubular polypyrrole grows orderly along the sphere surface and assembles to form a continuous conductive network.Conduction loss,dipole polarization,and interfacial polarization loss-acting as cooperative loss mechanisms-enable OJ‐MO‐PPy‐2.5 to achieve broadband effective absorption,with an effective absorption bandwidth of 7.2 GHz and a minimum reflection loss of−48.82 dB.Meanwhile,computer simulation technology(CST)simulation results indicate that after coating OJ‐MO‐PPy‐2.5,the reflection intensity of the electromagnetic wave is reduced by approximately three times when the wave is incident normally.The successful fabrication of OJ‐MO‐PPy furnishes novel insights for biomass‐derived electromagnetic wave absorption materials with broadband absorption capabilities.
基金supported by the National Natural Science Foundation of China(Grants U22B6004)PetroChina R&D Program(Grants 2021DJ0104,2022-KFKT-09).
摘要Understanding the evaporative loss of shale oil is critical for the shale oil resources assessment.However,previous studies have largely neglected the rapid evaporative loss of shale oil that occurs immediately after drill cores are retrieved to the surface at the well site.Thus,the factors influencing the evaporative loss of shale oil during thermal evolution remain inadequately explored.In this study,closed-system pyrolysis experiments were carried out to the artificially mature Qingshankou Formation shales.Subsequently,low-field nuclear magnetic resonance(LF-NMR)techniques were utilized to monitor the variations in oil content of the shales under different exposure times.Our experimental approach successfully reconstructed the entire evaporative loss process of shale oil,spanning from its original subsurface location to the well site,from the well site to the laboratory,and ultimately to long-term core storage.We find that the maximum loss of shale oil reaches approximately 10%within the first 10 h following the retrieval of drill cores from the subsurface to the ground,followed by a gradual deceleration,and the maximum loss ranges from 11%to 89%.As thermal maturity increases to a range of Ro=0.89%–1.20%,the loss proportion of shale oil shows a decreasing trend,which can be attributed to the reduction in total organic carbon(TOC)content.It is worth mentioning that the loss proportion of shale oil exhibits a continuous increasing trend at the thermal range of 1.20%–1.75%.At this stage,the hydrocarbon composition(C6–C14/C15+ratio)may be the mainly controlling factors for the shale oil loss proportion,while TOC content and nanopore volume serve as secondary factors.Our analyses reveal that hydrocarbon evaporative loss of shale oil is complex and involves various factors,especially the first 10 h during the transfer of the shale from its in-situ reservoir to the surface at the well site,which is critical to the understanding of shale oil occurrence and accurate resource assessment.
摘要The increasing overall pressure ratio of aero-engines has led to considerable windage losses in the Rear Drum Cavity(RDC)of the secondary air system.These losses convert turbine power into thermal energy,resulting in both energy consumption and a reduction in the rotor's operational lifetime.To expand the experimental database to engine-representative nondimensional conditions,a comprehensive experimental study was conducted,with the mass flow coefficient Cwranging from 3.54×104to 7.59×104and the rotational Reynolds number Reφranging from 3.31×106to 1.02×107.The effects of Cwand Reφon windage characteristics and swirl ratio distribution are analyzed.Furthermore,a theoretical model incorporating core swirl ratio modification and an empirical model are derived to predict windage losses.The experimental results indicate that windage losses are intensified by increasing Cwand Reф,leading to a maximum power consumption of 8 kW and a temperature rise of 54.6 K.Significant windage losses are predominantly driven by a weakened swirl ratio,which arises from the disturbance induced by the stator-mounted bolts.Particularly in the rear region of the RDC,the swirl ratio declines monotonically along the radial direction,showing minimal variation across all operating conditions,while the core swirl ratio remains consistently low,at approximately 0.2.Compared to the experimental data,the theoretical model exhibits an average error of 11%and the empirical model achieves a lower average error of 3%.These findings hold significant implications for enhancing the performance analysis of aero-engines.
基金financially supported by the National Key R&D Program of China(No.2023YFB3809200)the National Natural Science Foundation of China(No.52101239)+2 种基金the Ningbo Natural Science Foundation(No.2024J005)the Project of Leading Youth Talents for S&T Innovation in Ningbo(No.2024QL011)the"Pioneer"R&D Program of Zhejiang Province(No.2023C01075).
摘要Fe-based nanocrystalline powders are ideal soft magnetic materials for matching the wide bandgap semiconductors.Previously developed Fe-based nanocrystalline alloys are difficult to produce high-quality precursor powder by gas atomization due to their poor amorphous forming ability,and their following nanocrystallizations also require high temperatures or heating rates.In present work,we invented novel high-performance Fe-based nanocrystalline powders that can be directly manufactured by gas atomization without annealing.The as-atomized Fe73.3Si12B13Cu1.7nanocrystalline powders exhibit fine α-Fe(Si)crystals with an average size of 15.1 nm and high saturation magnetization(Ms)of 156.2 emu/g.The Fe73.3Si12B13Cu1.7soft magnetic powder cores annealed at 480℃for 60 min process high effective permeability of 35.9 and low core losses(50 mT/100 kHz)of 310.1 mW/cm3.These outstanding magnetic properties and good processability make the developed Fe73.3Si12B13Cu1.7nanocrystalline powders highly promising for high-performance inductors and transformers.
摘要Correction to:Nuclear Science and Techniques(2025)36:111 http://gffzzd3cc09b8251d45dfspuo5v9v9wu0b6kvn.ffgz.tsg.suse.edu.cn/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have read‘SCRs’.In Table 7 of this article,the column header ρ_fuel was incorrect and should have read CPv_fuel.For completeness and transparency,the old incorrect version and the corrected version of Table 7 are displayed below.
基金Supported by the National Defense Basic Scientific Research Program of China.
摘要Amphibious vehicles are more prone to attitude instability compared to ships,making it crucial to develop effective methods for monitoring instability risks.However,large inclination events,which can lead to instability,occur frequently in both experimental and operational data.This infrequency causes events to be overlooked by existing prediction models,which lack the precision to accurately predict inclination attitudes in amphibious vehicles.To address this gap in predicting attitudes near extreme inclination points,this study introduces a novel loss function,termed generalized extreme value loss.Subsequently,a deep learning model for improved waterborne attitude prediction,termed iInformer,was developed using a Transformer-based approach.During the embedding phase,a text prototype is created based on the vehicle’s operation log data is constructed to help the model better understand the vehicle’s operating environment.Data segmentation techniques are used to highlight local data variation features.Furthermore,to mitigate issues related to poor convergence and slow training speeds caused by the extreme value loss function,a teacher forcing mechanism is integrated into the model,enhancing its convergence capabilities.Experimental results validate the effectiveness of the proposed method,demonstrating its ability to handle data imbalance challenges.Specifically,the model achieves over a 60%improvement in root mean square error under extreme value conditions,with significant improvements observed across additional metrics.
摘要Description of the correction:The authors wish to make the following corrections to improve clarity and ensure appropriate attribution of related prior work.These corrections do not affect the results,analyses,or conclusions of the original article.1.Addition of relevant prior work in the Introduction section:After the sentence:“Schroff et al.[15]developed a triplet-based loss function for this problem to help the model go to a better learning representation,achieving better results and new record accuracy on multiple datasets.”The following text should be added:“Shen et al.[37,38]first proposed activity-cliff awareness loss and ACANet,which explicitly defined activity-cliff triplets based on activity differences and extended the triplet loss framework to regression tasks by adaptively adjusting the margin.In their formulation,the margin is dynamically modulated to pull samples closer or push them farther apart according to their label differences,enabling effective awareness of activity cliffs in molecular activity prediction.”
基金National Natural Science Foundation of China,Grant/Award Number:81271073。
摘要Background:Stem cell therapy offers promise for the neurodegenerative diseases and has been explored for sensorineural hearing loss(SNHL).However,effective cell delivery strategies remain a critical challenge for SNHL treatment.Methods:To address this need,we established an ouabain-induced SGN injured hearing loss model in rat and evaluated a novel transplantation strategy targeting the cochlear nerve surface via posterior occipital approach,designed to minimize cochlear structural damage and facilitate targeted cell delivery to Rosenthal's canal(RC).The temporal changes in glial cell densities within RC revealed a progressively deteriorating neural microenvironment,supporting early-stage intervention.Accordingly,hair follicle-derived neural crest stem cell(HFNCSC)transplantation was performed 3 or 4 days after modeling via two approaches:cochlear nerve surface transplantation(CNT)and round window transplantation(RWT).Results:CNT resulted in significant improvements in auditory function,as evidenced by reduced auditory brainstem response(ABR)thresholds,shortened waveⅠlatencies,and preserved waveⅠamplitudes post-transplantation.Transplanted cells were distributed along the nerve trunk and within RC.In contrast,RWT failed to improve auditory function and caused cochlear structural damage,with widespread cell dispersion in cochlear fluids.Notably,the CNT group exhibited significantly higher densities of TUJ1-positive neuron-like cells and glial cells in the RC,accompanied by enhanced myelin basic protein expression suggestive of remyelination.No such improvements were observed in the RWT group.Conclusions:These findings suggest that cochlear nerve surface transplantation enhances stem cell survival and auditory function recovery,and represents a promising delivery approach for stem cell-based therapy of SGN-related hearing loss.