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Atramacronins A-P,eudesmane-type sesquiterpenoid dimers from Atractylodes macrocephala with anti-hepatocellular carcinoma activities 认领 引用
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作者 Ganggang Zhou Xinru Li +10 位作者 Jiajia Liu Jiqiong Wang Zhaoyue Dong Ammara Khalid Yinda Qiu Zhihua Liao Guowei Wang Hui Liu Qingwen Zhang Min Chen Fancheng Meng 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期119-128,共10页
Atractylodes macrocephala Koidz.(A.macrocephala)is a medicinal and edible plant species belonging to the Compositae family.Its rhizome serves both therapeutic and nutritional purposes in China.This investigation led t... Atractylodes macrocephala Koidz.(A.macrocephala)is a medicinal and edible plant species belonging to the Compositae family.Its rhizome serves both therapeutic and nutritional purposes in China.This investigation led to the isolation of thirteen novel rearranged 9(8→7)-abeo-eudesmane-type sesquiterpenoid dimers(SDs),atramacronins A-M(1-13),three eudesmane-type SDs,atramacronins N-P(14-16),and two previously identified meroterpenoids,atrachinenin G(17)and atrachineninΙ(18),from Atractylodes macrocephala.Structure elucidation was accomplished through comprehensive spectroscopic analysis and single-crystal X-ray diffraction.Compounds 1,4-7,9,and 10 exhibited notable cytotoxicity against Hep3B,HepG2,and Huh7 cell lines,with half maximal inhibitory concentration(IC50)values ranging from 3.71 to 13.99μmol·L-1. 展开更多
关键词 Atractylodes macrocephala Sesquiterpenoid Cytotoxic activity Hepatocellular carcinoma
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Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma herbal pair restores intestinal mucosal barrier function in ulcerative colitis via activating Epac1/Rap1 pathway and inhibiting PI3K/AKT pathway 认领 引用
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作者 Xuecheng Yu Wenlong Su +7 位作者 Peng Huang Zengxiang Gao Yunya Lin Jiyuan Tu Yan Cao Yanju Liu Linlin Chen Guosheng Cao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期313-325,共13页
Ulcerative colitis (UC) is a persistent,diffuse intestinal inflammation and ranks among the most challenging chronic diseases worldwide.Atractylodes lancea (Thunb.) DC.and Atractylodis macrocephala Koidz.are tradition... Ulcerative colitis (UC) is a persistent,diffuse intestinal inflammation and ranks among the most challenging chronic diseases worldwide.Atractylodes lancea (Thunb.) DC.and Atractylodis macrocephala Koidz.are traditional Chinese medicines (TCMs) with a long history of clinical application,particularly for gastrointestinal disorders.Both Atractylodis Rhizoma (AR)and Atractylodis Macrocephala Rhizoma (AM) have shown significant efficacy in managing UC;however,the underlying mechanism by which the AR-AM herbal pair promotes intestinal mucosal healing remains poorly understood.The therapeutic effects of the ethanolic extract of AR-AM (EEAR-AM) were evaluated in a murine UC model induced by dextran sodium sulfate(DSS).A network pharmacology approach was employed to explore the anti-UC properties of EEAR-AM,including identification of active compounds,prediction of potential targets,and construction of a protein-protein interaction (PPI) network.Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were subsequently performed to preliminarily elucidate the mechanisms of EEAR-AM in UC treatment.Finally,the proposed molecular mechanisms were validated in both DSS-induced UC mice and Caco-2 cells.In vivo results demonstrated that EEAR-AM significantly attenuated DSS-induced weight loss,reduced colon shortening,lowered the disease activity index (DAI) score,and modulated the spleen coefficient.Moreover,EEAR-AM improved colonic tissue architecture,reduced inflammatory infiltration,restored goblet cell density,enhanced mucin MUC2 expression,and elevated levels of tight junction (TJ) proteins.Additionally,EEAR-AM suppressed the expression of matrix metalloproteinase 2 (MMP-2) and MMP-9.Network pharmacology analyses indicated that EEAR-AM may ameliorate intestinal mucosal dysfunction through modulation of the exchange protein directly activated by cAMP 1 (Epac1)/Ras-associated protein 1 (Rap1) pathway and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathways.These actions potentially enhance cellular barrier integrity and reduce the release of inflammatory mediators.Western blotting results confirmed that EEAR-AM activated the Epac1/Rap1 pathway while downregulating the PI3K/AKT pathway in both DSS-induced UC mice and Caco-2cells,consistent with predictions from network pharmacology.This study represents the first evidence that the EEAR-AM herbal pair improves intestinal mucosal barrier function in UC,with therapeutic effects likely mediated by activation of the Epac1/Rap1 pathway and inhibition of the PI3K/AKT pathway. 展开更多
关键词 Ulcerative colitis Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma Epac1/Rap1 PI3K/AKT Intestinal barrier
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Atractylodes macrocephala water extract exerts a protective effect against high fat and high sugar diet-induced NAFLD by inhibiting the TRAF1/ASK1/JNK pathway 认领 引用
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作者 Kejian Wei Binhui Pan +7 位作者 Jing Liu Wenlong Zhang Jie Su Hengpu Zhou Zimo Dong Jingjing Yu Suhong Chen Guiyuan Lyu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3195-3210,共16页
Non-alcoholic fatty liver disease(NAFL D)has emerged as a global health issue,making early prevention and treatment are crucial.Atractylodes macrocephala,as a functional food,holds potential in improving liver metabol... Non-alcoholic fatty liver disease(NAFL D)has emerged as a global health issue,making early prevention and treatment are crucial.Atractylodes macrocephala,as a functional food,holds potential in improving liver metabolic diseases.The aim of this study was to investigate whether A.macrocephala water extract(AMW)has a preventive effect on NAFLD induced by high-fat,high-sugar(HSHF)diet.Initially,the components of AMW were analyzed,revealing the high content of polysaccharides and lactones as its main constituents.Mice were then subjected to HSHF diet and administered AMW for 12 weeks to observe its effects on glucose and lipid metabolism,hepatic lipid accumulation,oxidative damage,inflammatory injury,and apoptosis.The results indicated that AMW significantly improved glucose and lipid metabolism disorders in mice,reduced hepatic lipid accumulation,oxidative damage,and inflammatory injury.Specifically,AMW notably decreased the release of tumor necrosis factor-alpha(TNF-α),thereby inhibiting the activation of the hepatic TRAF1/ASK1/JNK pathway,which alleviated the progression of inflammatory responses.Additionally,c-Jun N-terminal kinase(JNK)phosphorylation was reduced,inhibiting the activation of downstream factor activates protein kinase B(AKT),which in turn led to decreased expression of apoptosis-related factors such as Bcl-2-associated X protein(Bax),cytochrome C(Cyt C),and Cleaved Caspase-3,while increasing B-cell lymphoma-2(Bcl-2)expression.These findings suggest that AMW may protect against HSHF-induced NAFLD by reducing hepatic oxidative damage,inhibiting inflammation,and preventing apoptosis,potentially through inhibition of the TRAF1/ASK1/JNK pathway. 展开更多
关键词 Atractylodes macrocephala High-sugar and high-fat diet Non-alcoholic fatty liver disease Infl ammation Apoptosis TRAF1/ASK1/JNK
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Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra-performance liquid chromatography 认领 引用 被引量：2
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作者 Xiaoting Wang Xiaojun Li +2 位作者 Rui Zhang Yin Hong Jiaqi Guan 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第5期874-885,共12页
Background:In a previous study,we found that Atractylodes macrocephala and Paeoniae radix(AM-PR)was useful for the alleviation of functional constipation(FC).However,the precise mechanism underlying the compatibility ... Background:In a previous study,we found that Atractylodes macrocephala and Paeoniae radix(AM-PR)was useful for the alleviation of functional constipation(FC).However,the precise mechanism underlying the compatibility between AM and PR in the treatment of FC remains uncertain.This study aims to analyze the pharmacokinetic differences in the active ingredients in the blood of rat models with FC when applied individually and in combination with AM-PR.It also seeks to compare the changes in the content of the active ingredient when applied individually and in combination with in vitro AM-PR,further in-depth investigation into its material foundation in terms of pharmacokinetics,as well as the composition of the substance.Methods:Blood microdialysis samples were collected using microdialysis technology.These samples from rats with FC were compared after administration of AM,PR,and AM-PR.The concentration of the main active ingredients was determined using the Ultra Performance Liquid Chromatography-Tunable Ultraviolet(UPLC-TUV)method.The concentration of the main active ingredients of the decoction compatibility before and after combining AM-PR was also determined using the UPLC-TUV method.Results:Our findings reveal that upon combination,the time to maximum concentration(Tmax)of isochlorogenic acid A(ICA-A)and ataridolide Ⅱ(ATR-Ⅱ)Tmaxwas prolonged,terminal elimination half-life(T1/2)was reduced,and maximum plasma concentrations(Cmax)increased.The Tmaxof ataridolide Ⅲ(ATR-Ⅲ)remained consistent,whereas its T1/2and Cmaxwere significantly reduced.Conversely,for peoniflorin(PAE),Tmaxoccurred sooner,T1/2was shortened,and Cmaxincreased.The Tmaxfor albiflorin(ALB)remained consistent,whereas T1/2and Cmaxwitnessed significant increases.The area under the moment curve(AUMC)(0-t)and AUMC(0-∞)of PAE,ALB,ICA-A,ATR-Ⅱ experienced an increase after AM-PR administration in rats,attributable to the heightened Cmax.In comparison to individual herb administration,the Tmaxof ALB was advanced in combination,the Tmaxof PAE remained unchanged,and the Tmaxof ICA-A and ART-Ⅱ was delayed,with an increased area under the concentration-time curve(AUC)(0-t),indicating enhanced Cmaxand bioavailability.Furthermore,the dissolution rates of PAE,ICA-A,and ATR-Ⅱ significantly improved after compatibility.Conclusions:This study partially clarifies the rationale and compatibility of AM-PR in treating FC and offers a new perspective on the pharmacokinetic interactions of AM-PR in FC treatment. 展开更多
关键词 Atractylodes macrocephala microdialysis Paeoniae radix pharmacokinetics UPLC-TUV
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Atractylodimers A-D,unprecedented sesquiterpenoid dimers with cage-like skeletons from Atractylodes macrocephala and their neuroprotective activities 认领 引用
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作者 Bei Li Shiqi Zhou +7 位作者 Wei Wu Yulu Tian Yating Ren Jie Ma Yingda Zang Yuhe Yuan Dongming Zhang Chuangjun Li 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第12期122-128,共7页
Atractylodimers A-D(1-4),sesquiterpenoid dimers(SDs)featuring a unique cage-like structure,were isolated from the rhizomes of Atractylodes macrocephala.The most distinctive characteristic of these isolates was the hig... Atractylodimers A-D(1-4),sesquiterpenoid dimers(SDs)featuring a unique cage-like structure,were isolated from the rhizomes of Atractylodes macrocephala.The most distinctive characteristic of these isolates was the highly twisted“cap”structure based on highly twisted five-membered oxygen heterocyclic rings.Notably,compound 1 contained a furo[2,3b]furan ring,a caged 3,10-oxa-tricyclo[5.2.1.04,9]decane moiety,and 6/6/5/5/5/5/6/6 octocyclic skeleton.Compounds 2-3 exhibited a spiro-tetrahydrofuran ring,while compound 4 incorporated a caged spiro-2,5,9-oxa-tricyclo[5.2.1.04,10]decane scaffold for unit linkage.Their structures were definitively established through spectroscopic methods and X-ray diffraction experiments.Plausible biosynthetic pathways of compounds 1-4 were proposed.Compounds 1 and 2 demonstrated significant neuroprotective effects against serum deprivationinduced PC12 cell damage. 展开更多
关键词 Sesquiterpenoid dimers Caged polycyclic skeleton Atractylodes macrocephala X-ray diffraction Neuroprotective activities
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Current progress of Atractylodes macrocephala Koidz.:A review of its biogeography,PAO-ZHI processing,biological activities,biosynthesis pathways,and technology applications 认领 引用 被引量：1
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作者 Ruiwen Yang Huiyan Fan +6 位作者 Beihui He Qingyan Ruan Baoyu Wei Bing Han Xiaolong Hao Itay Maoz Guoyin Kai 《Medicinal Plant Biology》 2023年第1期173-190,共18页
The Atractylodes macrocephala Koidz.is a traditional Chinese rhizome herb,consumed for its well-known medicinal value.This review summarizes the recent research findings on biological activities,main biosynthesis path... The Atractylodes macrocephala Koidz.is a traditional Chinese rhizome herb,consumed for its well-known medicinal value.This review summarizes the recent research findings on biological activities,main biosynthesis pathways,PAO-ZHI processing,and technology application.The impact of biogeography led to significant differences in phenotypes and chemotypes.The PAO-ZHI processing also significantly affected A.macrocephala rhizome(AMR)bioactivity.A further systemic mechanistic investigation is required.Besides,new AMR polysaccharides with immunomodulatory effects,improving gastrointestinal function,and antitumor activity are constantly being isolated and characterized.Also,the discovery of novel families of compounds,such as the atractylenolides possessing antitumor,neuroprotective,immunomodulatory,and antiinflammatory activities,is still ongoing work.Advanced genetics tools,such as in-depth transcriptomics,provide the basis for exploring A.macrocephala resources'functional genetic and molecular regulatory mechanisms.Still,some pathways are more elusive than others,and the biosynthetic pathways of sesquiterpenes,one of the prominent active families,still present a challenge in AMR and other plants.We propose here new directions and opportunities to advance current research in AMR.This review lays the theoretical foundation for fully developing and utilizing A.macrocephala resources. 展开更多
关键词 pao zhi processing atractylodes macrocephala koidzis biogeography Atractylodes macrocephala koidz systemic mechanistic investigation biological activities biosynthesis pathways technology applications
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Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K^+ channel 认领 引用 被引量：17
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作者 ZENG Dan HU Can +6 位作者 LI Ru-Liu LIN Chuan-Quan CAI Jia-Zhong WU Ting-Ting SUI Jing-Jing LU Wen-Biao CHEN Wei-Wen 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2018年第9期674-682,共9页
Astragalus membranaceus(Radix Astragali, RA) and Atractylodes macrocephala(Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of... Astragalus membranaceus(Radix Astragali, RA) and Atractylodes macrocephala(Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on IEC-6 cell migration and explored the potential underlying mechanisms. A migration model with IEC-6 cells was induced using a single-edged razor blade along the diameter of cell layers in six-well polystyrene plates. The cells were grown in control--media or media containing spermidine(5 μmol·L-1, SPD), alpha-difluoromethylornithine(2.5 mmol·L-1, DFMO), 4-Aminopyridine-(40 μ-mol·L-1, 4-AP), the polysaccharide extracts of RA or RAM(50, 100, or 200 mg·L-1), DFMO plus SPD, or DFMO plus polysaccharide extracts of RA or RAM for 12 or 24 h. Next, cytosolic free Ca2+([Ca2+]cyt) was measured using laser confocal microscopy, and cellular polyamine content was quantified with HPLC. Kv1.1 mRNA expression was assessed using RT-qPCR and Kv1.1 and RhoA protein expressions were measured with Western blotting analysis. A cell migration assay was carried out using Image-Pro Plus software. In addition, GC-MS was introduced to analyze the monosaccharide composition of both polysaccharide extracts. The resutls showed that treatment with polysaccharide extracts of RA or RAM significantly increased cellular polyamine content, elevated [Ca2+]cyt and accelerated migration of IEC-6 cells, compared with the controls(P < 0.01). Polysaccharide extracts not only reversed the inhibitory effects of DFMO on cellular polyamine content and [Ca2+]cyt, but also restored IEC-6 cell migration to control level(P < 0.01 or < 0.05). Kv1.1 mRNA and protein expressions were increased(P < 0.05) after polysaccharide extract treatment in polyamine-deficient IEC-6 cells and RhoA protein expression was increased. Molar ratios of D-ribose, D-arabinose, L-rhamnose, D-mannose, D-glucose, and D-galactose was 1.0:14.1:0.3:19.9:181.3:6.3 in RA and 1.0:4.3:0.1:5.7:2.8:2.2 in RAM. In conclusion, treatment with RA and RAM polysaccharide extracts stimulated migration of intestinal epithelial cells via a polyamine-Kv1.1 channel activated signaling pathway, which facilitated intestinal injury healing. 展开更多
关键词 Intestinal epithelial cell (IEC-6) Cell migration Polysaccharide extracts Astragalus membranaceus Atractylodes macrocephala Polyamines K^+ channel
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Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala 认领 引用 被引量：5
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作者 Haixin Zhang Jingrong Li +8 位作者 Jinguang Si Chengya Dong Qi Li Meng Yu Lingling Qin Lingyu Li Chenxu Zhao Tao Zhang Zhongmei Zou 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第1期284-288,共5页
Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes macro... Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes macrocephala.Their structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray diffractions.The plausible biosynthetic pathways for compounds 1-3 are proposed.Surprisingly,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase. 展开更多
关键词 Atractylodes macrocephala Compositae Sesquiterpene-phenol hybrids Anti-cancer Neutrophil elastase
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Impacts of domestication on population genetics of a traditional Chinese medicinal herb,Atractylodes macrocephala(Asteraceae) 认领 引用 被引量：2
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作者 Chuan Chen Li zheng +4 位作者 Qing Ma Wen-Bin Zhou Yin Lu Yun-Peng Zhao Cheng-Xin Fu 《Journal of Systematics and Evolution》 SCIE CAS CSCD 2019年第3期222-233,共12页
As a medicinal herb,Atractylodes macrocephala Koidz.experienced centuries of cultivation in China,and germplasm resources of all cultivated populations have degraded over time as a consequence of domestication process... As a medicinal herb,Atractylodes macrocephala Koidz.experienced centuries of cultivation in China,and germplasm resources of all cultivated populations have degraded over time as a consequence of domestication processes.This study used chloroplast DNA and microsatellites to clarify not only the effects of domestication on population genetics,but also determine the geographic origins of landraces.The results revealed that cultivated populations(except the"Pingzhu"landrace)showed higher genetic diversity than their wild counterparts and lowlevels of genetic differentiation occurred between cultivated and wild groups.Furthermore,STRUCTURE and UPGMA analyses grouped all wild populations into three genotypic clusters,two of which(in Shaanxi and Hunan Province)shared the same gene pool with cultivated A.macrocephala,suggesting that wild populations in Central China have been involved in the origin of cultivated A.macrocephala.Moreover,the wild population from Qimen,Anhui Province and the cultivated"Pingzhu"landrace harbor unique gene pools and rare alleles that could be useful in future breeding efforts.This large-scale analysis of population genetics on a medicinal herb that has a centuries-long history of human-mediated selection will facilitate utilization and conservation of the valuable genetic resources of medicinal species. 展开更多
关键词 Atractylodes macrocephala cpDNA nSSR population genetics traditional Chinese medicine.
Analysis of the influence of processing of bran stir-baking on the main components of Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair by high-performance liquid chromatography 认领 引用 被引量：6
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作者 方新华 吴鑫 +2 位作者 曹岗 蔡皓 蔡宝昌 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第4期231-235,共5页
The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and pr... The crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pairs, originated from Bai-zhu-shao-yao-san, are used to treat different diseases clinically. In order to evaluate the crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs, a simple, easy, and sensitive high-performance liquid chromatography coupled with diode array detectors was developed for simultaneous determination of nine bioactive components in the herbal pairs. The calibration curve exhibited good linearity（r2≥0.9992）. The LODs and LOQs were ≤7.30 and 11.53 μg/m L, respectively. The intra-, inter-day and repeatability RSD values of the nine compounds were less than 3.86%, 2.71%, and 4.29%, respectively. The RSD stability values were less than 3.64%. The recovery of the method was in the range of 96.70%–102.10%, with RSD values less than 3.52%. The developed method can be applied to the intrinsic quality control of crude and processed Paeoniae Radix-Atractylodis Macrocephalae Rhizoma herbal pairs. 展开更多
关键词 High-performance liquid chromatography Processing Quantification Paeoniae Radix Alba Atractylodis Macrocephalae Rhizoma
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Analysis of the Causes of Continuous Cropping Obstacles for Atractylodes macrocephala Koidz in Pingjiang County and Its Control Methods 认领 引用 被引量：2
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作者 宋荣 邓凯 +2 位作者 朱校奇 周佳民 曹亮 《Agricultural Science & Technology》 CAS 2015年第3期462-466,共5页
First at all, it introduced the concept and the damages of continuous cropping obstacle. Then, it analyzed the causes of continuous cropping obstacles for Atractylodes macrocephala Koidz. In the end, in order to provi... First at all, it introduced the concept and the damages of continuous cropping obstacle. Then, it analyzed the causes of continuous cropping obstacles for Atractylodes macrocephala Koidz. In the end, in order to provide guidance for pro- moting sustainable development of Atractylodes macrocephala Koidz industry in Pingjiang County, it put forward some control methods for eliminating continuous cropping obstacles of Atractylodes macrocephala Koidz, including breeding varieties with high resistance; applying rotation cropping and intercropping reasonable; rational fertilization and soil disinfection; introducing antagonistic bacterial and eliminating au- tointoxication. 展开更多
关键词 Atractylodes macrocephala Koidz Continuous cropping obstacles Cause Damage Control method Pingjiang County
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Effect of Baizhu(Rhizoma Atractylodis Macrocephalae)extract on intestinal absorption of brucine and strychnine in vitro and in situ 认领 引用 被引量：4
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作者 Lu Dan Jiang Qieying +3 位作者 Zhang Jing Zeng Ronggui Liao Zhenggen Liang Xinli 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2020年第4期562-570,共9页
OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mech... OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mechanism of these effects.METHODS:The apparent permeability value(Papp)and absorption rate constant(Ka)were chosen as indices.The everted intestinal sac model and in situ single-pass intestinal perfusion model were used to study the effects of the RAM extract on the absorption of brucine and strychnine.To confirm the results,the brucine and strychnine concentrations in hepatic portal venous blood were determined.Western blotting was used to study P-glycoprotein(P-gp)expression in the Caco-2 cell line.RESULTS:Papp and Ka of brucine and strychnine were significantly increased in the presence of a P-gp inhibitor,but no significant increase was noted in the presence of a tight junction regulator.The RAM extract inhibited the absorption of brucine and strychnine and enhanced P-gp expression.CONCLUSION:The primary absorption mechanism for brucine and strychnine is passive transport,which is affected by P-gp. 展开更多
关键词 Strychnos nux-vomica Brucine Strychnine ATP binding cassette transporter,subfamily B,member 1 Baizhu(Rhizoma Atractylodis Macrocephalae)
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Effects of Atractylodes Macrocephala on the Cytomembrane Ca2+-activated K^+ Currents in Cells of Human Pregnant Myometrial Smooth Muscles 认领 引用 被引量：2
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作者 章小莉 汪琳 +1 位作者 徐龙 邹丽 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2008年第2期200-203,共4页
The study examined the inhibitory effect of Atractylodes macrocephala （AM） on the uterine contraction during premature delivery and explored its electrophysiological mechanism by studying the effects of AM on the C... The study examined the inhibitory effect of Atractylodes macrocephala （AM） on the uterine contraction during premature delivery and explored its electrophysiological mechanism by studying the effects of AM on the Ca^2＋-activated K^＋ currents of pregnant human myometrial smooth muscle cells with or without the treatment with intedeukin-6. Single cells were acutely isolated from pregnant human myometrial smooth muscles. Whole-cell Ca^2＋-activated K^＋ currents were recorded by using an Axopatchl-D amplifier. The cells were divided into three groups： group A in which AM was added into perfusate, group B, in which interleukin-6 was added into perfusate） and group C in which AM was added into perfusate after addition of interleukin-6. IL-6 10 ng/mL inhibited BKca by 36.9%±13.7% as compared with control （P〈0.01）. AM at 2 mg/mL raised BKca by 36.7%±22.6% or 45.2%±13.7% with or without the treatment of IL-6, respectively （P〈0.01）. It is concluded that AM was able to enhance the BKca of pregnant human myometrial smooth muscle cells treated or untreated with interleukin-6 and its effect on the BKca IL-treated cells was stronger that its effect on BKca of untreated cells. Our results suggested that AM can help to maintain the membrane potentials and the resting status of pregnant human myometrial smooth muscle cells. 展开更多
关键词 atractylodes macrocephala interleukin-6 patch clamp, Ca^2＋-activated K^＋ currents myometrial smooth muscle cells premature delivery
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Advances in research on chemical constituents,pharmacological actions and processing of atractylodes macrocephala 认领 引用
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作者 Ying ZHOU Jing-jing LI +1 位作者 Bao-xiang JIANG Xiao-yu XU 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2017年第10期1012-1012,共1页
Rhizome atractylodes macrocephalae is the dry roots of Atractylodes macrocephala Koidz.It is one of commonly used Chinese medicine.In the "Shennong′s Herbal",it was listed as the top grade.It mainly contain... Rhizome atractylodes macrocephalae is the dry roots of Atractylodes macrocephala Koidz.It is one of commonly used Chinese medicine.In the "Shennong′s Herbal",it was listed as the top grade.It mainly contains volatile oil,atractylenolides,atractylodes polysaccharides,glycosides and amino acids.And it has the medical functions of good for spleen and intestine,diuretic and dehumidification,hidroschesis,miscarriage prevention and soon.In order to provide references for further development and utilization,this paper systematic arranged the Chinese medicine atractylodes chemical composition,pharmacological effects,processing technology and effect of processing technology on chemical composition and pharmacological action. 展开更多
关键词 atractylodes macrocephala Koidz chemical constituents pharmacological effects processing technology
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Pharmacodynamic Substance and Mechanism of Atractylodes macrocephala in Treating PD Based on LC-MS and Network Pharmacology Technology 认领 引用
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作者 Zhe LI Lanqingqing ZHAO +3 位作者 Na LI Zi LIU Chunying ZHAO Hui XIONG 《Medicinal Plant》 2022年第6期1-6,13,共6页
[Objectives]The paper was to explore the pharmacodynamic substances and mechanism of Atractylodes macrocephala in treating primary dysmenorrhea(PD).[Methods]The components of A.macrocephala were qualitatively identifi... [Objectives]The paper was to explore the pharmacodynamic substances and mechanism of Atractylodes macrocephala in treating primary dysmenorrhea(PD).[Methods]The components of A.macrocephala were qualitatively identified by ultra high performance liquid chromatography quadrupole-time of flight mass spectrometry(UPLC-MS)combined with analyst TF 1.7.1 and peakview 2.2 software with reference to internal databases and literatures.The chemical components of A.macrocephala and the target of PD were collected by using network pharmacological data.The common genes were analyzed by Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)of genes and genomes with the help of String database and Metascape platform,and the affinity between core molecules and key targets was verified.[Results]A total of 23 chemical components of A.macrocephala were identified,and 301 gene targets of chemical components of A.macrocephala,614 targets of PD,and 25 intersection targets were obtained.GO analysis results obtained 505 biological processes,11 cellular components,and 33 molecular functions.KEGG pathway analysis showed that it mainly involved TNF signaling pathway,IL-17 signaling pathway,estrogen receptor signaling pathway and arachidonic acid metabolism.The top 4 targets of PPI network centrality and the top 5 compounds of A.macrocephala-component-target-disease network centrality were selected for docking.The docking results showed that atractylenolide I,Selinar-4(15),7(11)-dien-8-one,and atractylenolide II had strong binding ability.[Conclusions]A.macrocephala may exert a curative effect on PD by targeting atractylenolide I,Selinar-4(15),7(11)-dien-8-one,and atractylenolide II on key targets such as TNF,IL6,IL1β,PTGS2 to regulate cellular TNF signaling pathway,IL-17 signaling pathway,estrogen receptor signaling pathway,and arachidonic acid metabolism. 展开更多
关键词 Network pharmacology Atractylodes macrocephala Primary dysmenorrhea(PD) Mechanism of action Pharmacodynamic substance
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Control Effect of Validamycin against Seedling Blight of Atractylodes macrocephala 认领 引用
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作者 Huang Yajun Song Huiming Zhou Xiaojun 《Plant Diseases and Pests》 2018年第3期27-28,共2页
[Objective] The paper was to explore the effective agent against seedling blight of Atractylodes macrocephala. [Method] The control effects of 60% validamycin A SP against seeding blight of A. macrocephala were studie... [Objective] The paper was to explore the effective agent against seedling blight of Atractylodes macrocephala. [Method] The control effects of 60% validamycin A SP against seeding blight of A. macrocephala were studied in the field, and compared with that of control agent 20% bismerthiazol WP. [Result] At 14 d post the third spraying, the control effect of 60% validamycin A SP at the dose of 495-540 g/hm;was 76.9%,which was equivalent to that of control agent 20% bismerthiazol WP sprayed at the dose of 270 g/hm;（76.7%）. [Conclusion] 60% Validamycin A SP could be used as the ideal agent against seedling blight of A. macrocephala, with good prospects of application and popularization. 展开更多
关键词 Validamycin Atractylodes macrocephala Seedling blight Control effect
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Prescription and treatment rules for the prescriptions containing Poria cocos and Atractylodes macrocephala couplet medicine based on traditional Chinese Medicine inheritance support platform 认领 引用 被引量：1
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作者 Gan-Lin Sun Yun-Tong Wang +2 位作者 Yin-Zi Kong Hong Gui Lei Zhang 《TMR Theory and Hypothesis》 2020年第2期297-310,共14页
Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes... Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard·Traditional Chinese Medicine Set Prescription Preparation(called Traditional Chinese Medicine Set Prescription Preparation for short).After standardization,the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform(V2.5),and the relevant rules of the software were adopted.Data mining methods were used to analyze the frequency of drugs,main symptoms and diseases in prescriptions,and to analyze the regularity of prescriptions.The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed.Results:There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases.The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and stomach,and the high frequency syndromes were anorexia and irregular menstruation.Conclusion:The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases;it mostly takes tonifying deficiency efficat.It can treat different diseases being compatible with different medicinal materials.The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala. 展开更多
关键词 Couplet medicine of Poria cocos-Atractylodes macrocephala Trasitional Chinese Medicine set prescription preparation Syndrome and treatment rule Traditional Chinese Medicine Inheritance System
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Effects of Different Factors on the Contents of Atractylodes I, II and III in Atractylodes Macrocephala Koidz 认领 引用
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作者 LI Chun SU Yangyang +2 位作者 LI Hong JIA Wenjiang LI Peng 《外文科技期刊数据库（文摘版）医药卫生》 2021年第4期454-463,共10页
Objective: to study the effect of different conditions on the content change and internal law of Atractylenolide I, II and III. Methods: the samples of Atractylodes macrocephala Koidz were treated with different bakin... Objective: to study the effect of different conditions on the content change and internal law of Atractylenolide I, II and III. Methods: the samples of Atractylodes macrocephala Koidz were treated with different baking temperatures, baking time, humidity, open space time, sample morphology and other conditions. The contents of Atractylodes macrocephala Koidz I, II and III were determined by HPLC, and the change rules were analyzed. Results: for the original medicinal materials and decoction pieces, temperature and heating time had a certain effect on the conversion amount, but the effect was limited. However, under the influence of the appropriate heating temperature and heating time, the content of pulverized sample powder changed significantly. In the case of Atractylodes macrocephala Koidz in the form of powder, with the increase of storage time, the content of Atractylenolide I, II and III changed significantly. Conclusion: comparison of the content change law of Atractylodes macrocephala Koidz lactone I, II, III is conducive to optimizing the processing method of Atractylodes macrocephala Koidz, and provides a reference for the quality control of Atractylodes macrocephala Koidz. 展开更多
关键词 Atractylodes macrocephala Koidz atractylenolide I, II, III HPLC method processing
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Rhizoma Atractylodis Macrocephalae reduces HFD-induced MAFLD in mice through activated AMPK-mediated inhibition of fatty acid synthesis 认领 引用 被引量：1
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作者 Ke Zheng Ruishuo Zhang +7 位作者 Yijing Xin Yuge Zhou Jiacheng Lin Weifan Huang Fang Wang Liu Yang Xuehua Sun Xiaoni Kong 《Liver Research》 CSCD 2025年第2期157-168,共12页
Background and aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a common chronic condition that can lead to cancer due to its complex pathogenesis.Therapeutic agents targeting AMPactivated protein ki... Background and aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a common chronic condition that can lead to cancer due to its complex pathogenesis.Therapeutic agents targeting AMPactivated protein kinase(AMPK)activation have been suggested as potential treatments for metabolic disorders such as metabolic dysfunction-associated steatohepatitis(MASH).Rhizoma Atractylodis Macrocephalae(RAM)has been clinically used to treat obesity-related health problems,but its therapeutic effects on MAFLD and the underlying mechanism remain unclear.Therefore,this study was conducted to evaluate the function and underlying mechanism of RAM in the treatment of MAFLD.Methods:The effect of RAM decoction on MAFLD was evaluated using a high-fat diet(HFD)-induced MAFLD mouse model.In vitro studies were conducted using a palmitic acid/oleic acid-induced lipid accumulation model in the alpha mouse liver 12 cells and RAM-containing serum.The underlying mechanisms were elucidated through a combination of network pharmacology analysis,immunohistochemistry,western blotting,and polymerase chain reaction analysis.Results:Administration of RAM decoction significantly reduced body weight gain in MAFLD mice without changing food intake.The weights of the liver and inguinal adipose tissues were also reduced after RAM treatment.Additionally,RAM administration decreased serum levels of alanine aminotransferase,aspartate transaminase,total cholesterol,triglyceride,low-density lipoprotein cholesterol,and glucose,while reducing lipid droplet accumulation in the liver tissues of MAFLD mice.The underlying mechanisms included the activation of the phosphorylation of AMPK and acetyl-CoA carboxylase(ACC),and inhibition of the expression of sterol regulatory element binding protein 1(SREBP1).However,RAM did not alter the protein expression levels of peroxisome proliferator-activated receptor a and carnitine palmitoyltransferase-1a.Furthermore,the RAM-induced upregulation of phosphorylated AMPK,phosphorylated ACC,and SREBP1 expression,as well as the downregulation of fatty acid synthase expression,were reversed by using an AMPK inhibitor.Conclusions:Through a combination of network pharmacology and experimental validation,we demonstrated that RAM may exert therapeutic effects on MAFLD by inhibiting lipid synthesis and activating phosphorylated AMPK pathways. 展开更多
关键词 Metabolic dysfunction-associated fatty liver disease(MAFLD) Rhizoma Atractylodis Macrocephalae(RAM) AMP-activated protein kinase(AMPK) Hepatic steatosis
白术有效成分及抗肿瘤机制研究进展 认领 引用 被引量：4
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作者 张玉梅 王敬毅 +4 位作者 崔思远 刘奎 郑伟 王振振 丁继元 《中华中医药学刊》 CAS CSCD 北大核心 2026年第3期169-174,共6页
中药白术为菊科植物白术Atractylodes macrocephala Rhizoma的根茎,具有健脾益气、燥湿利水、止汗、安胎之效,其有效成分主要包括内酯类、多糖类、挥发油类、黄酮类、苷类等。现代药理学研究显示,白术具有调节胃肠道、保护心血管和神经... 中药白术为菊科植物白术Atractylodes macrocephala Rhizoma的根茎,具有健脾益气、燥湿利水、止汗、安胎之效,其有效成分主要包括内酯类、多糖类、挥发油类、黄酮类、苷类等。现代药理学研究显示,白术具有调节胃肠道、保护心血管和神经系统、保肝、抗肿瘤、抗炎、抗菌、抗氧化、调节免疫等功效,可用于胃肠道、神经系统、肝脏、免疫系统、肿瘤等多种疾病的治疗与预防。将白术有效成分的抗肿瘤机制研究进行归纳,其可通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞迁移和侵袭、阻滞肿瘤细胞周期、抑制肿瘤新生血管生成和调节肿瘤微环境等多种途径发挥抗肿瘤作用。旨在为白术及其有效成分的抗肿瘤应用提供重要参考依据。 展开更多
关键词 白术 抗肿瘤 细胞增殖 细胞迁移和侵袭 细胞凋亡 细胞周期 肿瘤新生血管生成 肿瘤微环境
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