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Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study 认领 引用 被引量：1
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作者 FENG Sisi XIAO Xiaomin +2 位作者 ZHOU Manli HUANG Zixin ZHONG Baiyun 《中南大学学报（医学版）》 CAS CSCD 北大核心 2026年第1期118-128,共11页
Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrat... Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC. 展开更多
关键词 inflammatory cytokines serum metabolites colorectal carcinoma Mendelian randomization genome-wide association study metabolomics analysis
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Integrated multi-omics analysis unveils metabolites-mediated microbial interactions:dynamic regulation and metabolic division of A.flavus SU-16 and S.cerevisiae HJ during co-fermentation 认领 引用
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作者 Shuangping Liu Mingliang Li +5 位作者 Hailong Sun Zhuoyue Zheng Yuezheng Xu Xiao Han Zhilei Zhou Jian Mao 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1757-1773,共17页
This study aimed to gain insight into the interaction and metabolic mechanism between Aspergillus flavus U-16 and Saccharomyces cerevisiae HJ during co-fermentation.Despite the suppressed transcriptional activity of S... This study aimed to gain insight into the interaction and metabolic mechanism between Aspergillus flavus U-16 and Saccharomyces cerevisiae HJ during co-fermentation.Despite the suppressed transcriptional activity of SU-16,its metabolites exerted a pivotal regulatory influence.The metabolites produced by SU-16 significantly increased the ethanol content to 17.0%.They also significantly increased the contents of crucial flavor substances,including amino acids(at least 5 times)and esters(up to 1100 mg/L).SU-16 produced 130 metabolites that may affect flavor compounds,while HJ mainly controlled the synthesis of 161 compounds.Metabolites of SU-16 with different molecular weights were observed to exert differential regulatory effects on the fermentation process and the metabolic pathway of HJ.The small molecule metabolites of SU-16 promoted the growth of HJ significantly.In contrast,its macromolecular metabolites were found to mainly affect the expression of genes related to carbohydrate and amino acid metabolism in the HJ genome. 展开更多
关键词 Co-fermentation Metabolites Interaction Dual RNA-seq Transcriptomic Metabolomics
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Benzyl sulfide, sulfoxide and sulfinate metabolites from Gastrodia elata and their synthesis, derivatization and anti-inflammatory activity 认领 引用
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作者 Chengbo Xu Lei Wang +7 位作者 Xue Zhou Shuai Shao Chengjuan Chen Xiaoqiang Lei Tiantai Zhang Jiachen Zi Jiangong Shi Qinglan Guo 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期365-372,共8页
Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were ... Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were isolated from the aqueous extracts of Gastrodia elata.Compounds 1 and 4 are 4-hydroxy-3-(4′-hydroxybenzyl)benzyl-substituted sulfoxide and sulfide, respectively, which are unprecedented in natural products. Compound 3 represents a rare sulfinate. Several isolates and their sulfone and disulfide analogs(10-13) were synthesized to evaluate their anti-inflammatory activity. Notably, the synthesized sulfone 10 demonstrated significant alleviation of symptoms in multiple in vivo inflammatory models. 展开更多
关键词 Gastrodia elata Sulfur-bearing benzyl metabolites Synthesis Anti-inflammatory activity
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Characterizing the regulation mechanism of microbial community and metabolites in multi-layer vinegar starter(Cuqu)via Muqu fortification strategy 认领 引用
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作者 Qiuxiang Tang Nan Zhou +4 位作者 Jun Huang Jian Guo Xuemei Kang Wen Luo Rongqing Zhou 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2115-2126,共12页
Improving the quality of Cuqu is one of the necessary strategies increasing the quality and yield of fresh vinegar.Enhancing the consistency and characteristics of Cuqu is currently a prominent area of research.Here,w... Improving the quality of Cuqu is one of the necessary strategies increasing the quality and yield of fresh vinegar.Enhancing the consistency and characteristics of Cuqu is currently a prominent area of research.Here,we investigated the impact of fortified Muqu(FM)consisting of Bacillus velezensis and Bacillus subtilis on enhancing the quality of Cuqu compared to conventional Muqu(CM).Our results demonstrated that FM significantly increased the abundance of Bacillus by 1.85-8.19 times,as well as substantially elevated Kroppenstedtia abundance in Cuqu.Source Tracker analysis revealed a higher proportion of bacteria originating from FM in Cuqu compared to those derived from CM,indicating superior environmental adaptability for bacteria in the FM.Additionally,upregulation in expression levels of pyrazine-related key enzymes within Cuqu microbial communities was observed due to FM,resulting in a remarkable 39.70-fold increase in pyrazine compounds production.Multiphase detection technology confirmed that FM improved similarity in microbial community structure and function at different spatial positions within Cuqu.These results elucidated the regulatory function of FM in forming microbial communities and metabolic mechanisms within Cuqu,providing valuable insights for optimizing and predicting traditional fermentation processes in industrial production. 展开更多
关键词 Microbial communities Metabolites pattern Spatial distributions Pyrazine content
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Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue 认领 引用
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作者 Zi-Xuan Liu Xiao-Yan Liu +4 位作者 Wei-Wei Tan Wei-Bing Zhang Ya-Li Zhang Lie Zheng Yan-Cheng Dai 《World Journal of Gastroenterology》 SCIE CAS 2026年第3期103-127,共25页
BACKGROUND Ulcerative colitis(UC)is a chronic,non-specific inflammatory bowel disease.The gut microbiome undergoes significant changes in UC.Fatigue is a highly prevalent and debilitating extraintestinal symptom of UC... BACKGROUND Ulcerative colitis(UC)is a chronic,non-specific inflammatory bowel disease.The gut microbiome undergoes significant changes in UC.Fatigue is a highly prevalent and debilitating extraintestinal symptom of UC,which negatively affects quality of life.However,its relationship with gut microbes and metabolites remains unclear.AIM To assess the gut microbiota and metabolomic characteristics of patients with UC with fatigue(HUCF).METHODS A total of 120 participants were recruited and divided into four groups(n=30 per group)based on the diagnosis of UC and Fatigue Scale-14 scores:HUCF,UC without fatigue(HUCN),healthy with fatigue(HHF),and healthy without fatigue(HHN).Fresh stool samples were collected for 16S rRNA sequencing and untargeted metabolomic analysis.RESULTS Metabolomic analysis revealed significant differences among the four groups(principal component analysis/partial least squares discriminant analysis,P=0.001),with differential expression of metabolites such as linoleoyl ethanolamide,arachidonoyl ethanolamide,glycocholic acid,and thromboxane(TX).Notably,TX was detected only in the HUCF group.Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed alterations in eicosanoid,tryptophan,and tyrosine metabolism in the HUCF group.Microbial richness and diversity were significantly lower in the HUCF group than in the other three groups.The HUCF group showed enrichment of Hyphomicrobiales,Brucella,Eisenbergiella,Pediococcus,and Sellimonas.The HUCN group showed enrichment of Campylobacter-related taxa.The HHF group showed enrichment of Fusobacterium,Desulfovibrionaceae,and Bilophila.The HHN group showed enrichment of beneficial genera such as Adlercreutzia.Notably,Anaerococcus,a beneficial genus,was enriched in the HUCF group.Correlation analysis indicated that specific microbes(e.g.,Faecalibacterium and Escherichia-Shigella)were associated with the severity of UC and fatigue.CONCLUSION Patients with HUCF exhibit a distinct gut microbial structure and metabolomic profile.The pro-inflammatory metabolite TX and the genus Anaerococcus are uniquely enriched in patients with HUCF,suggesting their potential roles in the development of HUCF.These findings provide novel insights and a theoretical basis for improving the clinical management of HUCF. 展开更多
关键词 Ulcerative colitis Fatigue Gut Microbiota Metabolites Thromboxane Anaerococcus
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Minimalistic metabolite piezoelectric self-assembly for the development of implantable bioelectronics for in vivo monitoring 认领 引用
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作者 Zengfeng Qiu Ruiqi Liu +10 位作者 Haoye Jiang Xiaoyue Ma Lujing Gao Zixuan Liu Jiahao Zhang Yancheng Wang Jiqian Wang Syed A.M.Tofail Deqing Mei Hai Xu Kai Tao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2026年第3期563-578,I0012-I0035,共16页
Amino acid non-centrosymmetric self-assemblies,possessing inherent polarization as well as biocompatibility,can be employed as bioinspired alternatives for the development of implantable piezoelectric bioelectronics.T... Amino acid non-centrosymmetric self-assemblies,possessing inherent polarization as well as biocompatibility,can be employed as bioinspired alternatives for the development of implantable piezoelectric bioelectronics.This could enable the harvesting of biomechanical energy for in situ in vivo monitoring and avoid the need for secondary surgeries,potentially overcoming the trade-off between high-efficiency sensing and the biosafety limitations of traditional inorganic or polymeric piezoelectric counterparts.In this regard,the electromechanical coupling behaviors of the minimalistic metabolite self-assemblies are reported.Experimental tests reveal that compared to other natural amino acid crystals,threonine(T)crystals exhibit a high Young’s modulus of up to approximately 80 GPa by forming a denser three-dimensional hydrogen-bonding network,with each molecule interacting with seven adjacent ones.Computational analysis reveals that side-chain entities dramatically affect crystal packing,with polar hydroxyl moieties accounting for the distinct piezoelectric features underlying the macroscopic performance.This highlights the potential of exploiting T crystals to develop biodegradable piezoelectric bioelectronics that exhibit highly sensitive linear responses for tactile sensing and post-implantation in vivo motion monitoring.This study demonstrates the feasibility of exploiting minimalistic metabolite self-assemblies for piezoelectric bioelectronics in bio-machine interface and biomedical engineering applications. 展开更多
关键词 Metabolites Piezoelectricity Implantable bioelectronics Self-assembly
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Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages 认领 引用
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作者 Jie Yang Wen-Li Sai +5 位作者 Xiao-Xiao Xia Hao Tang Min Xu Qun Xie Deng-Fu Yao Min Yao 《World Journal of Gastroenterology》 SCIE CAS 2026年第24期97-116,共20页
BACKGROUND Differential metabolites(DMs)are associated with metabolic dysfunction-associated fatty liver disease(MAFLD)malignant transformation.However,their underlying mechanisms remain to be identified.AIM To invest... BACKGROUND Differential metabolites(DMs)are associated with metabolic dysfunction-associated fatty liver disease(MAFLD)malignant transformation.However,their underlying mechanisms remain to be identified.AIM To investigate the dynamic alterations of DMs,carnitine palmitoyl transferase-II(CPT-II)and immune cells during MAFLD malignancy.METHODS A rat model was constructed with high fat diet plus 2-fluorenylacetamide to induce hepatocyte malignancy.Livers were divided into MAFLD,metabolic dysfunction-associated steatohepatitis,liver cirrhosis(LC)and hepatocellular carcinoma(HCC)groups based on hematoxylin and eosin staining,with normal rats as control.DMs were identified via RNA transcriptomics or metabolomics.Proteins were detected by western blotting,and immune cells were analyzed by single-cell sequencing.RESULTS Model livers with obvious lipid accumulation and cells were examined during MAFLD malignancy from inflammation or necrosis to LC or HCC and exhibited a pathological alteration of nuclear pleomorphism,disordered arrangement and a progressive decrease in CPT-II activity.The number of DMs was 131 in MAFLD,134 in metabolic dysfunction-associated steatohepatitis,27 in liver fibrosis/LC,and 130 in HCC,respectively.Cyclin B1 and cyclin-dependent kinase 1 were involved in the P53 pathway and cell cycle,and they held key positions in the protein interaction network,which involved metabolic regulation of cell response to stimuli.DMs,such as phosphatidylcholine or sphingomyelin in steroid biosynthesis,were significantly related to MAFLD malignancy.Mechanistically,liver immune cells undergo dynamic changes in a fat-rich microenvironment,with decreased T cell abundance and increased programmed death ligand 1 expression and M2-polarized macrophages.CONCLUSION Downregulated CPT-II aggravates the accumulation of metabolites associated with MAFLD malignancy via immune evasion and M2-polarized macrophages. 展开更多
关键词 Differential metabolites Carnitine palmitoyl transferase-II Immune escape Differentially expressed genes M2-polarized macrophages Hepatocarcinogenesis
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Lipid metabolism and metabolites:emerging roles in systemic physiology and metabolic diseases 认领 引用
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作者 Jiesi Xu Dongliang Lu Xun Huang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第7期1143-1158,共16页
Lipids function as central regulators of cellular and systemic physiology through their roles in energy storage,membrane architecture,signaling,and nutrient transport.Maintaining lipid metabolic balance is essential,a... Lipids function as central regulators of cellular and systemic physiology through their roles in energy storage,membrane architecture,signaling,and nutrient transport.Maintaining lipid metabolic balance is essential,as its disruption underlies a broad spectrum of metabolic and metabolic-related disorders,including fatty liver disease,obesity,cardiovascular disease,neurodegeneration,and infections.Recent studies have uncovered roles for phospholipids,sphingolipids,lipid-related metabolites,and lipoproteins as metabolic modulators in regulating disease development or mediating inter-organ communication.In this review,we summarize emerging insights into lipid metabolism and metabolite function,with an emphasis on their contribution to the pathogenesis of diseases.We further highlight how these discoveries reshape our understanding of lipid biology and open new avenues for therapeutic intervention. 展开更多
关键词 Lipids Lipid metabolism Metabolites Metabolic diseases Inter-organ crosstalk
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Microbiota–metabolite axis in endometriosis:Pathogenic mechanisms and clinical implications 认领 引用 被引量：1
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作者 Moyuan Li Aiyuan Yue +6 位作者 Lingfeng Gu Feiyang Li Nuo Ye Sujuan Xu Zhen Gong Dake Li Pengfei Xu 《Journal of Biomedical Research》 CAS CSCD 2026年第4期347-363,共17页
Growing evidence highlights the gut,reproductive tract,and endometrial microbiota as important functional contributors in the pathogenesis of endometriosis(EM).Studies have revealed a characteristic microbial imbalanc... Growing evidence highlights the gut,reproductive tract,and endometrial microbiota as important functional contributors in the pathogenesis of endometriosis(EM).Studies have revealed a characteristic microbial imbalance in patients with EM,marked by a reduced abundance of beneficial bacteria and an enrichment of opportunistic pathogens.These microbial communities are thought to influence disease progression primarily through metabolic activity,as demonstrated by metabolomic studies showing their capacity to modulate host immune and endocrine responses.This imbalance may contribute to several key metabolic disturbances,including decreased levels of short-chain fatty acids,particularly butyrate;a shift in tryptophan metabolism toward the kynurenine pathway;elevated β-glucuronidase activity;increased lipopolysaccharide production;and altered secondary bile acid profiles.Functionally,these metabolic alterations are thought to contribute to EM by disrupting immune homeostasis,enhancing estrogen signaling,and driving systemic inflammation,thereby creating a permissive microenvironment for ectopic lesion growth and invasion.Targeted interventions,such as probiotics,high-fiber dietary strategies,fecal microbiota transplantation,and selective modulation of microbial or host metabolic enzymes,are emerging as promising non-hormonal therapeutic approaches.Nonetheless,further studies incorporating longitudinal cohort designs and integrative multi-omics approaches are essential to establish causality and facilitate the development of precise diagnostic and personalized treatment strategies. 展开更多
关键词 endometriosis microbiota metabolite
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Metabolite-mediated crosstalk:unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens 认领 引用 被引量：1
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作者 Shaobo Zhang Xinghua Zhao +2 位作者 Xin He Wanyu Shi Ning Ma 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期655-674,共20页
Fatty liver hemorrhagic syndrome(FLHS)in laying hens is a metabolic disorder characterized by excessive hepatic lipid accumulation,inflammation,and hemorrhage,bearing pathological similarities to human non-alcoholic f... Fatty liver hemorrhagic syndrome(FLHS)in laying hens is a metabolic disorder characterized by excessive hepatic lipid accumulation,inflammation,and hemorrhage,bearing pathological similarities to human non-alcoholic fatty liver disease.With the rise of intensive poultry farming,the incidence of FLHS has markedly increased,resulting in significant economic losses in the poultry industry.The gut microbiota plays a crucial role in host digestion,metabolism,and immune regulation,particularly in liver diseases.Gut microbiota and its metabolites influence liver health via the gut-liver axis.This review aims to explore metabolite-mediated interactions between the laying hens and the gut microbiota,elucidating their role in the pathogenesis of FLHS.Host-derived metabolites,such as lipids,bile acids,amino acids,and carbohydrates,regulate the structure and function of the gut microbiota through the gut-liver axis,playing a role in FLHS progression.Concurrently,microbial metabolites,including short-chain fatty acids,bile acids,and amino acid derivatives,influence hepatic lipid metabolism,inflammation,and oxidative stress,driving the development of FLHS.Key microbes,such as Bacteroides,Lactobacillus,and Akkermansia muciniphila,are considered potential therapeutic targets due to their involvement in metabolite production.By integrating multi-omics data and mechanistic studies,this review highlights the central role of host–gut microbiota communication in FLHS and provides a theoretical basis and research direction for the development of microbiota-based intervention strategies. 展开更多
关键词 Fatty liver hemorrhagic syndrome Gut-liver axis Gut microbiota Metabolites Non-alcoholic fatty liver disease
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Secondary metabolite profiling deciphers the phenolic and volatile organic compound diversity within an interspecific Malus collection 认领 引用
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作者 Genny Zambiasi Marta Degasperi +8 位作者 Iuliia Khomenko Franco Biasioli Domenico Masuero Urska Vrhovsek Nicola Busatto Walter Guerra Michela Troggio Fabrizio Costa Brian Farneti 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第7期1554-1566,共13页
Secondary metabolites play fundamental roles in apple,influencing the interaction with pollinators and frugivores for seed dispersal,contributing to fruit quality and promoting human health through their antioxidant p... Secondary metabolites play fundamental roles in apple,influencing the interaction with pollinators and frugivores for seed dispersal,contributing to fruit quality and promoting human health through their antioxidant property.Domestication and breeding have significantly re-shaped the apple metabolism,altering both aromatic profiles and nutritional properties.This study assessed the secondary metabolite variation in a comprehensive Malus spp.collection comprising 163 accessions belonging to 44 species.The profiling of phenolic and volatile organic compounds(VOCs),performed with Ultra-Performance Liquid Chromatography(UPLC)and Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry(PTR-ToF-MS)instruments respectively,in both skin and pulp tissues,uncovered distinct metabolic patterns between wild and domesticated apples.This investigation underlined the higher concentration of these metabolites in the skin tissue and revealed a clear metabolic divergence between the two groups of Malus accessions.Wild Malus spp.accessions resulted particularly rich in specific polyphenols characterized by antioxidant activity,including catechin and procyanidins.Conversely,apples of Malus domestica accessions exhibited a more abundant VOC profile,particularly represented by esters associated with fruity aroma,enhancing sensory appeal.These findings provide a foundation for leveraging wild germplasm in breeding programs,and the identification of accessions with high polyphenolic concentration and desirable aromatic profiles offers valuable opportunities to improve the aromatic and nutraceutical properties of apple. 展开更多
关键词 Apple Diversity Secondary metabolites Polyphenols VOCs Domestication Quality
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Metabolite Profiling and Skin Anti-Aging Potential of Astragalus sarcocolla:Antioxidant,Enzyme Inhibitory,and Computational Insights 认领 引用
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作者 Shaimaa R.Ahmed Omnia M.Hendawy +2 位作者 Sumera Qasim Hanan Khojah Ambreen Malik Uttra 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第2期119-138,共20页
The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract(ASE)by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase(MMP),collagenase,elastase,hyaluronid... The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract(ASE)by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase(MMP),collagenase,elastase,hyaluronidase,and tyrosinase in relation to its chemical composition.Ultra Performance Liquid Chromatography-Mass Spectrometry(UPLC-MS)identified 27 metabolites(15 flavonoids,8 phenolic acids and their derivatives,and 4 coumarins).ASE showed strong antioxidant capacity in DPPH(IC50value of 26.05μg/mL)and FRAP(2433μM FeSO4/g extract)assays.The extract inhibited MMP-1 and MMP-9 in a concentration-dependent manner and suppressed collagenase,elastase,hyaluronidase,and tyrosinase activities(IC50=35.038,40.748,61.389,and 30.980μg/mL,respectively).A network pharmacology study was conducted to uncover the mechanisms responsible for skin anti-aging effects,and molecular docking further evaluated interactions of key metabolites with hub targets.Twenty-one bioactive metabolites,selected based on oral bioavailability and drug-likeness,highlighted cinnamic acid,acacetin,luteolin,kaempferol,and apigenin as key compounds.MMP-9,ESR1,PTGS-2,and EGFR were identified as main targets.Docking studies revealed that acacetin and apigenin have stronger binding affinities to MMP-9,PTGS-2,and EGFR than other constituents.These findings suggest that ASE may serve as a natural multi-target skin anti-aging remedy with potential cosmetic applications. 展开更多
关键词 Astragalus sarcocolla metabolite profiling aging metalloproteinase network pharmacology
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Research on Secondary Metabolites from a Mangrove-Derived Fungus Penicillium janthinellum XLN32122 and Their Biological Activities 认领 引用
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作者 Shi Jueying Qiu Yikang +6 位作者 Lan Jing Xu Zhenyang Wang Yi Li Jiaxiang Luo Youping Huang Guolei Zheng Caijuan 《有机化学》 SCIE CAS CSCD 北大核心 2026年第2期678-683,共6页
new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core,named trichodermamide H(1),and three known analogues,along with three known polyketides,were isolated from the fermentation extract of the... new heterocyclic dipeptide with a highly functionalized 1,2-oxazadecaline core,named trichodermamide H(1),and three known analogues,along with three known polyketides,were isolated from the fermentation extract of the mangrovederived fungus Penicillium janthinellum XLN32122.The structure of 1 was elucidated on the basis of extensive 1D and 2D NMR spectra data analysis,HR-ESI-MS,electronic circular dichroism(ECD)calculations.Trichodermamide B(3)exhibited better inhibitory effect on nitric oxide(NO)production in lipopolysaccharide(LPS)induced RAW 264.7 cells with an IC50value of(13.13±0.005)μmol/L than that of the positive control dexamethasone[IC50=(136.84±1.33)μmol/L].Compound 3 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus(MRSA)with an IC50value of 12.5μg/mL,while the positive control vancomycin showed an IC50value of 1.563μg/mL. 展开更多
关键词 mangrove-derived fungi secondary metabolites anti-inflammatory activity antibacterial activity
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Metabolite-QTL analysis reveals genetic basis of phenolic acid metabolism in barley grains 认领 引用
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作者 Ruilian Song Siyu Zhang +7 位作者 Yixiang Wang Yuhan Liu Likun Liu Chen Zhang Yanjun Li Qifei Wang Genlou Sun Xifeng Ren 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第5期879-893,共15页
Phenolic acid metabolites play important physiological roles,and many genetic loci affecting phenolic acid metabolism traits have been identified in several crops.Although barley is one of the important cereal crops,r... Phenolic acid metabolites play important physiological roles,and many genetic loci affecting phenolic acid metabolism traits have been identified in several crops.Although barley is one of the important cereal crops,research on the genetic basis of phenolic acid synthesis in barley grains remains limited.Here,we analyze the 39 phenolic acid metabolites detected in mature grains of barley double haploid(DH)population and further identify 154 metabolite quantitative trait loci(mQTLs)related to 36 phenolic acids using four mapping methods.Subsequently,we identify 12 candidate genes that affect the content of phenolic acid metabolites,and overexpression of one candidate gene,HvCOMT-1,in barley reveals its involvement in the synthesis of phenolic acids.Moreover,we show that the transcription factor HvMYB-1 regulates the expression of HvCOMT-1.Functional analysis in Arabidopsis shows that HvCOMT-1 increases stem diameter and lignin deposition.Further analysis reveals that the expression level of HvCOMT-1 is closely related to the barley lodging-related traits.Overall,our findings enhance the understanding of the genetic basis for phenolic acid variations in mature barley grains and provide valuable reference for genetic improvement of barley nutritional quality. 展开更多
关键词 Barley Mature grains Phenolic acid metabolites mQTL HvCOMT-1
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Metabolite-derived fluorescence signals track decay of biochemical oxygen demand throughout dissolved organic matter biodegradation 认领 引用
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作者 Hehe Wang Yinghui Mo +6 位作者 Kang Xiao Yichen Tian Yizhe Lai Xin Zhao Jianqing Du Jihua Tan Xia Huang 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第6期1-14,共14页
Monitoring biochemical oxygen demand(BOD)decay offers critical insights into the aerobic biodegradation of dissolved organic matter(DOM).Focusing on the accumulated metabolites generated during DOM biodegradation,this... Monitoring biochemical oxygen demand(BOD)decay offers critical insights into the aerobic biodegradation of dissolved organic matter(DOM).Focusing on the accumulated metabolites generated during DOM biodegradation,this study introduces novel fluorescence parameters that facilitate the rapid monitoring of BOD decay throughout the entire DOM degradation process until BOD is depleted.BOD decay during degradation of four synthetic DOM samples was first investigated(initial BOD0.93;p0.8;p<0.001).The findings present a promising approach for rapid tracking and early warning of BOD decay during DOM degradation,potentially contributing to water quality management. 展开更多
关键词 Biochemical oxygen demand Dissolved organic matter Fluorescence spectroscopy Kinetic modeling Metabolites
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Plasma Metabolites Mediate the Associations of Gut Microbial Diversity with Ambulatory Blood Pressure and Its Variability 认领 引用
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作者 Zhenghao Tang Zhennan Lin +9 位作者 Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Keyong Huang Hongfan Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第1期26-35,共10页
Objective Evidence suggests that depleted gut microbialα-diversity is associated with hypertension;however,whether metabolic markers affect this relationship remains unknown.We aimed to determine the potential metabo... Objective Evidence suggests that depleted gut microbialα-diversity is associated with hypertension;however,whether metabolic markers affect this relationship remains unknown.We aimed to determine the potential metabolites mediating the associations ofα-diversity with blood pressure(BP)and BP variability(BPV).Methods Metagenomics and plasma targeted metabolomics were conducted on 523 Chinese participants from the MetaSalt study.The 24-hour,daytime,and nighttime BP and BPV were calculated based on ambulatory BP measurements.Linear mixed models were used to characterize the relationships betweenα-diversity(Shannon and Chao1 index)and BP indices.Mediation analyses were performed to assess the contribution of metabolites to the observed associations.The influence of key metabolites on hypertension was further evaluated in a prospective cohort of 2,169 participants.Results Gut microbial richness(Chao1)was negatively associated with 24-hour systolic BP,daytime systolic BP,daytime diastolic BP,24-hour systolic BPV,and nighttime systolic BPV(P<0.05).Moreover,26 metabolites were strongly associated with richness(Bonferroni P<0.05).Among them,four key metabolites(imidazole propionate,2-hydroxy-3-methylbutyric acid,homovanillic acid,and hydrocinnamic acid)mediated the associations between richness and BP indices(proportions of mediating effects:14.1%–67.4%).These key metabolites were also associated with hypertension in the prospective cohort.For example,each 1-standard deviation unit increase in hydrocinnamic acid significantly reduced the risk of prevalent(OR[95%CI]=0.90[0.82,0.99];P=0.03)and incident hypertension(HR[95%CI]=0.83[0.71,0.96];P=0.01).Conclusion Our results suggest that gut microbial richness correlates with lower BP and BPV,and that certain metabolites mediate these associations.These findings provide novel insights into the pathogenesis and prevention of hypertension. 展开更多
关键词 Ambulatory blood pressure monitoring Gut microbial richness Plasma metabolites Mediation Hypertension
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Physicochemical Properties of Quinoa RS3 Resistant Starch and Its Effects on Intestinal Flora and Metabolites during in Vitro Fermentation 认领 引用
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作者 WANG Hui MU Xindi +5 位作者 SU Tingting YANG Xiyuan XU Lei YAO Di WANG Changyuan ZHANG Liyuan 《食品工业科技》 EI CAS 北大核心 2026年第12期12-26,共15页
To understand the physicochemical properties of quinoa RS3-type resistant starch(RS3-type QRS)and the effects of its in vitro fermentation on the intestinal flora and short-chain fatty acids(SCFAs),quinoa starch(QS)wa... To understand the physicochemical properties of quinoa RS3-type resistant starch(RS3-type QRS)and the effects of its in vitro fermentation on the intestinal flora and short-chain fatty acids(SCFAs),quinoa starch(QS)was prepared via alkali extraction and then autoclaved to obtain RS3-type QRS,and the amylose content,transmittancy,pasting properties,and thermal properties of both starches were analyzed.The in vitro fermentation characteristics of the two and their effects on intestinal metabolites were further explored using an in vitro fecal simulation fermentation system,16S rRNA sequencing,liquid chromatography-mass spectrometry,and non-targeted metabolomics.Compared with QS,RS3-type QRS had significantly higher contents of resistant starch and amylose(P<0.05),significantly improved transmittancy and solubility(P<0.05),possessed more stable thermodynamic properties,and was better in quality and easier to cook.After adding RS3-type QRS to the in vitro fermentation matrix,the abundance of Faecalibacterium increased whereas that of Escherichia-Shigella decreased.Members of the Firmicutes,including Blautia and Lactococcus,formed the core community in RS3-type QRS and were significantly positively correlated with butyric acid enrichment(P<0.01 or P<0.05).In metabolic pathways of bile secretion,the bile acid levels were significantly increased(P<0.05).SCFAs produced by the intestinal flora,together with the differential metabolites,maintained intestinal homeostasis.The findings from this study provide a reference for exploring the impact of RS3-type QRS on intestinal health and a theoretical basis for its application. 展开更多
关键词 quinoa RS3 resistant starch in vitro fermentation intestinal flora metabolites bile acids
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Gut Associated Metabolites Enhance PD-L1 Blockade Efficacy in Prostate Cancer 认领 引用
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作者 Ke Liu Xia Xue +11 位作者 Haiming Qin Jiaying Zhu Meng Jin Die Dai Youcai Tang Ihtisham Bukhari Hangfan Liu Chunjing Qiu Feifei Ren Pengyuan Zheng Yang Mi Weihua Chen 《Oncology Research》 SCIE 2026年第2期550-569,共20页
Background:The gut microbiome has emerged as a critical modulator of cancer immunotherapy response.However,the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer(P... Background:The gut microbiome has emerged as a critical modulator of cancer immunotherapy response.However,the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer(PC)remain not fully explored.The study aimed to explore how gut metabolites regulate death-ligand 1(PD-L1)blockade via exosomes and boost immune checkpoint inhibitors(ICIs)in PC.Methods:We recruited 70 PC patients to set up into five subgroups.The integrated multi-omics analysis was performed.In parallel,we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines and transgenic adenocarcinoma of the mouse prostate(TRAMP)models.Results:We identified two metabolites,16(R)-Hydroxyeicosatetraenoic acid(16(R)-HETE)and 6-Keto-Prostaglandin E1(6-Keto-PGE1),that positively correlated with the plasma exosomal PD-L1 levels.The in vitro experiments found that both 16(R)-HETE and 6-Keto-PGE1 can enhance PD-L1 expression at the mRNA,protein,and exosome levels in both human and mouse PC cell lines,which were also validated in vivo based on subcutaneous mouse models.Both metabolites significantly promoted the anti-PD-L1 efficacy against PC in situ on a TRAMP mouse model.Conclusions:Targeting the“gut-tumor metabolic axis”is a promising strategy to improve the efficacy of immune checkpoint inhibitors in tumors. 展开更多
关键词 Gut microbiome metabolites prostate cancer programmed death-ligand 1 immunotherapy gut-tumor metabolic axis
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Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome 认领 引用
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作者 Eita Toyoshi Masahiro Watanabe +21 位作者 Fu Namai Kenji Yamane Toma Kashima Wakako Ikeda-Ohtsubo Afifah Zahra Agista Ayu Yoshida Taiga Sakuma Itsuko Fukuda Kasumi Suzuki Gou Yoshioka Yuji Imai Sae Tsuchida Eri Nishiyama Hiroki Shinkai Yoshihiro Muneta Hirohide Uenishi Ryuta Tobe Hitoshi Shirakawa Masamitsu Maekawa Nariyasu Mano Haruki Kitazawa Keita Nishiyama 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第3期1404-1422,共19页
Background Food by-products,such as corn germ meal from starch processing,are increasingly used as sustainable feed supplements,reducing competition between food and feed and supporting the valorisation of food waste.... Background Food by-products,such as corn germ meal from starch processing,are increasingly used as sustainable feed supplements,reducing competition between food and feed and supporting the valorisation of food waste.However,their effects on gut microbial metabolism and host health remain unclear.This study aimed to determine how corn germ meal fermentation influences microbial community structure and metabolite production using an ex vivo pig faecal culture system.Results Corn germ meal supplementation significantly altered the microbial composition,increasing diversity and enriching fibre-degrading Prevotellaceae,a key bacterial family involved in complex carbohydrate metabolism.Metabolomic analysis revealed marked increases in tryptophan-derived metabolites,including indoleacrylic acid,indolepropionic acid,and indolelactic acid,which act as ligands for the aryl hydrocarbon receptor and have anti-inflammatory properties.Prevotella-mediated catabolite repression reduced Escherichia coli-derived indole formation,redirecting microbial tryptophan metabolism toward the production of these bioactive compounds.Microbial and metabolic responses differed among farms,reflecting farm-specific microbiome structures.Conclusions Corn germ meal supplementation reshapes gut microbial communities,enhances metabolic activity,and promotes the generation of bioactive tryptophan metabolites with potential immunomodulatory effects.These findings highlight the value of corn by-products as dietary fibres that can drive beneficial microbial cross-feeding and influence host intestinal homeostasis.Although demonstrated in an ex vivo setting,this study provides a mechanistic basis and preclinical evidence for future in vivo studies,supporting the sustainable utilisation of food industry by-products to improve gut health and resource efficiency in livestock production. 展开更多
关键词 Aromatic amino acid metabolism Aryl hydrocarbon receptor Corn germ meal Ex vivo fermentation Microbial metabolites Sustainable feed ingredients Swine nutrition
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Lifestyle behaviors,serum metabolites and high myopia:Mendelian randomization and mediation analysis 认领 引用
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作者 Nian-En Liu Xiao-Tong Xu Xiao-Bing Yu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第1期140-148,共9页
AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analy... AIM:To explore the causal relationship between several possible behavioral factors and high myopia(HM)using multivariable Mendelian randomization(MVMR)approach and to find the mediators among them with mediation analysis.METHODS:The causal effects of several behavioral factors,including screen time,education time,time spent outdoors,and physical activity,on the risk of HM using univariable Mendelian randomization(MR)and MVMR analyses were first assessed.Genome-wide association study summary statistics of serum metabolites were also used in mediation analysis to determine the extent to which serum metabolites mediate the effects of behavioral factors on HM.RESULTS:MR analyses indicated that both increased time spent outdoors and a higher frequency of moderate physical activity significantly reduced the risk of HM.Further MVMR analysis confirmed that moderate physical activity independently contributed to a lower risk of HM.Additionally,MR analyses identified 13 serum metabolites significantly associated with HM,of which 12 were lipids and one was an amino acid derivative.Mediation analysis revealed that six lipid metabolites mediated the protective effects of moderate physical activity on HM,with the highest mediation proportion observed for 1-(1-enyl-palmitoyl)-GPC(p-16:0;30.83%).CONCLUSION:This study suggests that in addition to outdoor time,moderate physical activity habits may have an independent protective effect against HM and pointed to lipid metabolites as priority targets for the prevention due to low physical activity.These results emphasize the importance of physical activity and metabolic health in HM and underscore the need for further study of these complex associations. 展开更多
关键词 high myopia physical activity serum metabolites multivariable Mendelian randomization mediation analysis
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