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Protein post-translational modification in plants:regulation and beyond 认领 引用 被引量：1
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作者 Zhenxiang Li Liqian Qin +7 位作者 Dongjiao Wang Tianzhen Cui Yanlan Liang Shoujian Zang Tingting Sun Wanying Zhao Qibin Wu Youxiong Que 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第5期969-984,共16页
Post-translational modification(PTM)of proteins is a crucial regulatory mechanism in plant cells,enabling rapid and purposeful regulation of their functions.Modified proteins play various roles in signaling pathways,i... Post-translational modification(PTM)of proteins is a crucial regulatory mechanism in plant cells,enabling rapid and purposeful regulation of their functions.Modified proteins play various roles in signaling pathways,including plant growth and development,plant metabolism,and the response to adversity stress.In recent years,there has been an increase in the number of studies focusing on plant PTM maps and functional analysis.Here we aim to review the PTM types in plants,especially in horticultural plants and tropical crops,the interactions between and among PTMs,and more importantly,the underlying pathways and functions.Additionally,the potential application of PTMs in breeding is briefly discussed.This paper focuses on plant PTMs and provides a foundation for further investigation into the functions and regulatory mechanisms of PTMs in plant proteins as well as for crop improvement. 展开更多
关键词 Protein post-translational modification PTM types Pathways and functions Crosstalk Regulatory mechanism Crop improvement
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Lactate and lactylation modifications in neurological disorders 认领 引用 被引量：1
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作者 Yu Gu Keyang Chen +5 位作者 Chunyan Lei Xinglong Yang Lu Wang Linhu Zhao Wen Jiang Qionghua Deng 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1681-1697,共17页
Research into lactylation modifications across various target organs in both health and disease has gained significant attention.Many essential life processes and the onset of diseases are not only related to protein ... Research into lactylation modifications across various target organs in both health and disease has gained significant attention.Many essential life processes and the onset of diseases are not only related to protein abundance but are also primarily regulated by various post-translational protein modifications.Lactate,once considered merely a byproduct of anaerobic metabolism,has emerged as a crucial energy substrate and signaling molecule involved in both physiological and pathological processes within the nervous system.Furthermore,recent studies have emphasized the significant role of lactate in numerous neurological diseases,including Alzheimer's disease,Parkinson's disease,acute cerebral ischemic stroke,multiple sclerosis,Huntington's disease,and myasthenia gravis.The purpose of this review is to synthesize the current research on lactate and lactylation modifications in neurological diseases,aiming to clarify their mechanisms of action and identify potential therapeutic targets.As such,this work provides an overview of the metabolic regulatory roles of lactate in various disorders,emphasizing its involvement in the regulation of brain function.Additionally,the specific mechanisms of brain lactate metabolism are discussed,suggesting the unique roles of lactate in modulating brain function.As a critical aspect of lactate function,lactylation modifications,including both histone and non-histone lactylation,are explored,with an emphasis on recent advancements in identifying the key regulatory enzymes of such modifications,such as lactylation writers and erasers.The effects and specific mechanisms of abnormal lactate metabolism in diverse neurological diseases are summarized,revealing that lactate acts as a signaling molecule in the regulation of brain functions and that abnormal lactate metabolism is implicated in the progression of various neurological disorders.Future research should focus on further elucidating the molecular mechanisms underlying lactate and lactylation modifications and exploring their potential as therapeutic targets for neurological diseases. 展开更多
关键词 astrocyte-neuron lactate shuttle theory brain functions brain lactate metabolism central nervous system histone lysine lactylation monocarboxylate transporters nervous system neurodegenerative diseases non-histone lysine lactylation post-translational modifications
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Anion modification for enhanced anode catalyst performance in seawater electrolysis 认领 引用
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作者 Wei Wei Ruize Ma +7 位作者 Ruguang Wang Jisi Li Quanlu Wang Zheng Lv Hui Jin Jinshuai Xu Jiaxin Guo Tao Ling 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第6期1768-1784,共17页
Direct seawater electrolysis presents a promising pathway for sustainable“green hydrogen”production.However,the complex composition of seawater,particularly the presence of chloride ions(Cl−),poses significant ch... Direct seawater electrolysis presents a promising pathway for sustainable“green hydrogen”production.However,the complex composition of seawater,particularly the presence of chloride ions(Cl−),poses significant challenges to the structural stability and electrocatalytic performance of oxygen evolution reaction(OER)catalysts.Although recent studies have demonstrated that anion modification can improve the stability and activity of catalysts,the extent of these improvements varies considerably across different anions,and the underlying mechanisms remain poorly understood.This review examines the electrochemical behavior of anions related to their physicochemical properties and provides a comprehensive overview of recent advances and remaining challenges in anion-oriented strategies for seawater electrolysis.First,we propose a novel framework for determining anion properties based on adsorption energy,ionic potential,and acid-base character,which evaluates the physicochemical properties of anions from three dimensions and serves as a guideline for selecting modification materials for catalysts.Second,we critically discuss the underlying mechanisms by which anion modification enhances OER stability and activity in seawater,with a focus on chlorine chemistry and oxygen evolution dynamics.Classical approaches for stability improvement,such as the introduction of external anions and the regulation of Cl−and hydroxide ions(OH−),are discussed.We also summarize mechanisms for activity enhancement,including electronic structure modulation,active species engineering,and mass transfer optimization.Finally,we outline future research directions for anion modification strategies and highlight persistent challenges. 展开更多
关键词 seawater electrolysis anion modification green hydrogen oxygen evolution reaction catalyst stability chloride corrosion
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Effect of modification treatment on microstructure and properties of Fe-B-C alloy 认领 引用
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作者 Li-qiong Zhong Qiang Xiao +2 位作者 Feng-shuo Jin Wei-ji Lai Yan-liang Yi 《China Foundry》 SCIE EI CAS CSCD 2026年第2期215-222,共8页
The network structure of M2B in Fe-B-C alloy readily leads to the failure of material.In this work,by adding K2_SO4,the morphology of the M2B was successfully regulated through a synergistic treatment combining ... The network structure of M2B in Fe-B-C alloy readily leads to the failure of material.In this work,by adding K2_SO4,the morphology of the M2B was successfully regulated through a synergistic treatment combining active element modification and heterogeneous nucleation modification.The results show that after the addition of K2SO4,a new phaseα-MnS forms in the alloy,and the active element K enriches at the M2B/matrix interface.This inhibits the growth of the network M2B and promotes its transformation from a continuous network structure to an isolated blocky structure.As the K2SO4 addition increases from 0wt.%to 4.46wt.%,the shape factor value of M2B increases from 0.067 to 0.353,with an increase of 426%.The impact toughness of the alloy increases from 5.9 J·cm-2to 14.2 J·cm-2,and the fracture mode transitions from cleavage fracture to ductile-cleavage mixed fracture.Three-body abrasion tests indicate that with increasing K2SO4 addition,the wear weight loss of the alloy gradually decreases.The alloy with 4.46wt.%K2SO4 addition exhibits the least wear damage and the best wear resistance.This work provides an effective approach for regulating the microstructure and improving the wear resistance of wear-resistant Fe-B-C alloys. 展开更多
关键词 Fe-B-C alloy borides modification three-body abrasion
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Fat mass and obesity-mediated N6-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury 认领 引用
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作者 Xiangrong Chen Jinqing Lai +4 位作者 Zhe Wu Jianlong Chen Baoya Yang Chunnuan Chen Chenyu Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期730-741,共12页
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N6-methyladenosine is ubiqui... The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N6-methyladenosine is ubiquitous in the immune response of the central nervous system.The fat mass and obesity-related protein catalyzes the demethylation of N6-methyladenosine modifications on mRNA and is widely expressed in various tissues,participating in the regulation of multiple diseases’biological processes.However,the role of fat mass and obesity in microglial activation and the subsequent neuroinflammatory response after traumatic brain injury is unclear.In this study,we found that the expression of fat mass and obesity was significantly down-regulated in both lipopolysaccharide-treated BV2 cells and a traumatic brain injury mouse model.After fat mass and obesity interference,BV2 cells exhibited a pro-inflammatory phenotype as shown by the increased proportion of CD11b+/CD86+cells and the secretion of pro-inflammatory cytokines.Fat mass and obesity-mediated N6-methyladenosine demethylation accelerated the degradation of ADAM17 mRNA,while silencing of fat mass and obesity enhanced the stability of ADAM17 mRNA.Therefore,down-regulation of fat mass and obesity expression leads to the abnormally high expression of ADAM17 in microglia.These results indicate that the activation of microglia and neuroinflammatory response regulated by fat mass and obesity-related N6-methyladenosine modification plays an important role in the pro-inflammatory process of secondary injury following traumatic brain injury. 展开更多
关键词 ADAM17 epigenetic modification fat mass and obesity N6-methyladenosine microglia mRNA nerve injury neuroinflammation traumatic brain injury tumor necrosis factorα
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Effects of(Al-Ti-La+Nd)modification and heat treatment on microstructure and properties of Al-7Si alloy 认领 引用
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作者 Wan-wu DING Jian-chao CHEN +4 位作者 Xu-dong TIAN Jia-zhi AN Hai-cun YU Hai-xia ZHANG Guo-li WEI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第4期1026-1038,共13页
The effects of adding a novel Al-3Ti-4.35La master alloy and Nd and heat treatment on the microstructure and mechanical properties of Al-7Si alloy were investigated.The results showed that the secondary dendrite arm s... The effects of adding a novel Al-3Ti-4.35La master alloy and Nd and heat treatment on the microstructure and mechanical properties of Al-7Si alloy were investigated.The results showed that the secondary dendrite arm spacing ofα-Al in the as-cast Al-7Si alloy was refined from 18.3 to 11.9μm after modification with 0.2 wt.%Al-Ti-La and 0.03 wt.%Nd,and the length of eutectic Si was reduced from 8.6 to 5.0μm.After heat treatment at 535°C for 3 h followed by 165°C for 3 h,the morphology of the eutectic Si became more rounded,and the size decreased.The microhardness,ultimate tensile strength,and elongation were HV 66.1,184.9 MPa,and 24.4%,respectively,which increased by 24.2%,11.6%,and 194.0%compared to the as-cast state.The addition of Al-3Ti-4.35La master alloy and Nd can reduce the nucleation temperature of eutectic Si in Al-7Si,thereby suppressing its growth.Notably,the Ti2(Al,Si)20(La,Nd)phase formed in the Al-7Si alloy after the addition of Al-Ti-La and Nd adhered to or coexisted near the eutectic Si particles,inhibiting their growth. 展开更多
关键词 Al-7Si alloy Al-Ti-La master alloy Nd modification heat treatment
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m6A-RegBase enables regulatory investigation of m6A RNA modification in plants 认领 引用
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作者 Beilei Lei Pengjun Ding +9 位作者 Minggui Song Yuhang Ma Tingrui Shi Wen Sun Jing Yang Chengchao Jia Chujun Zhang Mengmeng Yuan Zenglin Li Chuang Ma 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第5期954-957,共4页
N6-methyladenosine(m6A)is a prevalent mRNA modification that is essential for diverse biological processes.Recent advances in high-throughput sequencing,including RNA immunoprecipitation sequencing(RIP-seq)and n... N6-methyladenosine(m6A)is a prevalent mRNA modification that is essential for diverse biological processes.Recent advances in high-throughput sequencing,including RNA immunoprecipitation sequencing(RIP-seq)and nanopore direct RNA sequencing(dRNA-seq),have enabled comprehensive profiling of m6A methylomes across tissues,conditions,and species.Correspondingly,numerous bioinformatics tools and databases have been developed to mine these datasets. 展开更多
关键词 rip seq nanopore direct rna sequencing drna seq methylome bioinformatics tools mrna modification rna immunoprecipitation sequencing rip seq m drna seq
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Structural Modification and Deformable Design of Electrospun Sn@C Nanofiber Anodes Through Oxide Doping for Flexible Lithium-Ion Batteries 认领 引用
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作者 Yu Xin Jiaxiang Li +4 位作者 Zhiyan Wang Chang Miao Shi Pan Chengjin Liu Wei Xiao 《Rare Metals》 SCIE EI CAS CSCD 2026年第5期655-666,共12页
Size-controllable Sn nanoparticles are designed in this work via oxide doping to be uniformly embedded into flexible N-doped carbon nanofibers,in which the agglomeration and migration of Sn are effectively restrained ... Size-controllable Sn nanoparticles are designed in this work via oxide doping to be uniformly embedded into flexible N-doped carbon nanofibers,in which the agglomeration and migration of Sn are effectively restrained due to the suppressive effect of selected oxides,including SiO2,TiO2,and ZnO.Benefiting from unique merits of the embedment structure,such as ultrahigh aspect ratio,superior adhesion,and ideal stability,the flexible freestanding and highly robust electrode(Sn/TiO2@C,STC)is fabricated and exhibits a reversible specific capacity of 968.4 mAh g-1after 100 cycles at 0.1 A g-1.Moreover,the STC electrode contributes to a cycle lifespan of over 1000 cycles with a high specific capacity of 519.7 mAh g-1at 1.0 A g-1and a capacity decay as low as 0.00185%per cycle.Remarkably,practical application potential of the STC electrode was demonstrated by being assembled into a pouch cell,which not only works stably under bending states but also presents a specific capacity of 954.8 mAh g-1after 150 cycles at 0.1 A g-1.This composite fiber anode avoids extra use of polymer binder,current collector,and conductive additive,and exhibits a great potential in the practical application of flexible energy storage devices. 展开更多
关键词 deformable design lithium-ion battery nanofiber anode oxide doping structural modification
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Advancements in design,surface modification,and spinal applications of biomedical metallic materials for bone repair 认领 引用
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作者 Shiqiang Song Lizhu Tang +3 位作者 Longjian Huang Yuanli Luo Huiqing Yang Chengliang Yang 《Metals Advances》 SCIE EI CAS CSCD 2026年第4期49-65,共17页
Bone defect repair imposes stringent requirements on biomaterials,including mechanical compatibility,biocompatibility,osteoinduction/osteoconduction,and biodegradability.Biomedicalmetallic materials serve as core solu... Bone defect repair imposes stringent requirements on biomaterials,including mechanical compatibility,biocompatibility,osteoinduction/osteoconduction,and biodegradability.Biomedicalmetallic materials serve as core solutions for bone reconstruction due to their exceptional mechanical strength,particularly in high-loadbearing regions such as the spine.To address metallic surface bioinertness,various surface modification technologies are widely employed to significantly enhance osseointegration,antibacterial efficacy,and corrosion resistance through microano-structuring and bioactive coatings.3D printing enables customized fabrication of porous metallic implants,optimizing mechanical compatibility and imaging compatibility.In spinal applications,metallic materials are extensively utilized in internal fixation systems,interbody cages,artificial discs/vertebrae,correction systems,and tumor prostheses.Their design and modification directly impact fusion success rates,anti-subsidence capability,and long-term stability.Despite significant progress,challenges remain in degradation rate matching,long-term biosafety,multifunctional synergy,and stability in complex physiological environments.Future efforts should focus on smart materials,precision surface engineering,AI-assisted personalized design,and long-term clinical evaluation to advance metallic bone-repair materials toward superior performance. 展开更多
关键词 Biomedical metallic materials Bone repair Surface modification Spinal implants 3D printing Osseointegration
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Stability enhancement of MnOx-CeO2via hydrophobic modification for NO reduction by NH3 认领 引用
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作者 Boyu Wu Shengen Zhang +2 位作者 Shengyang Zhang Bo Liu Bolin Zhang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第1期357-368,共12页
MnOx-CeO2catalysts for the low-temperature selective catalytic reduction(SCR)of NO remain vulnerable to water and sulfur poisoning,limting their practical applications.Herein,we report a hydrophobic-modified MnO... MnOx-CeO2catalysts for the low-temperature selective catalytic reduction(SCR)of NO remain vulnerable to water and sulfur poisoning,limting their practical applications.Herein,we report a hydrophobic-modified MnOx-CeO2catalyst that achieves enhanced NO conversion rate and stability under harsh conditions.The catalyst was synthesized by decorating MnOx crystals with amorphous CeO2,followed by loading hydrophobic silica on the external surfaces.The hydrophobic silica allowed the adsorption of NH3and NO and diffusion of H,suppressed the adsorption of H2O,and prevented SO2interaction with the Mn active sites,achieving selective molecular discrimination at the catalyst surface.At 120℃,under H2O and SO2exposure,the optimal hydrophobic catalyst maintains 82%NO conversion rate compared with 69%for the unmodified catalyst.The average adsorption energies of NH3,H2O,and SO2decreased by 0.05,0.43,and 0.52 eV,respectively.The NO reduction pathway follows the Eley-Rideal mechanism,NH3*+*→NH2*+H*followed by NH2*+NO*→N2*+H2O*,with NH3dehydrogenation being the rate determining step.Hydrophobic modification increased the activation energy for H atom transfer,leading to a minor decrease in the NO conversion rate at 120℃.This work demonstrates a viable strategy for developing robust NH3-S CR catalysts capable of efficient operation in water-and sulfur-rich environments. 展开更多
关键词 Mn-Ce catalyst NH3-SCR hydrophobic modification enhanced stability
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Enhanced SO2resistance of the Pd/Silicate-1 catalyst by rare earth oxide modification in methane combustion 认领 引用
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作者 Jinxiong Tao Hongxia Lin +8 位作者 Yuxi Liu Jiguang Deng Lin Jing Zhiwei Wang Lu Wei Zhen Wei Zhiquan Hou Zexu Zhang Hongxing Dai 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第3期647-657,共11页
The inherent irreducibility and limited sulfur dioxide tolerance of zeolites constrain oxygen exchange efficiency in palladium/zeolite catalysts,which can adversely affect their performance in methane combustion.Herei... The inherent irreducibility and limited sulfur dioxide tolerance of zeolites constrain oxygen exchange efficiency in palladium/zeolite catalysts,which can adversely affect their performance in methane combustion.Herein,a novel molecular sieve(Silicate-1,denoted as S-1)catalyst functionalized with rare earth oxide sites was developed for catalytic methane combustion.Although both Pd/S-1@CeO2-30(in which CeO2content was 30 wt.%)and Pd/S-1 catalysts demonstrated comparable initial catalytic activities,the Pd/S-1@CeO2-30 sample achieved a methane reaction rate of 114.0μmol/(gPd·s)and the highest TOFPd(0.033s-1),with a 90%methane conversion at 424℃ at a space velocity of 20,000 mL/(g h).The CeO2shell in Pd/S-1@CeO2-30 exhibited the superior longterm stability that was attributed to the redox property of CeO2,which could facilitate the provision of abundant oxygen species.As a result,the Pd/S-1@CeO2-30 catalyst maintained stable performance in 10,000-ppm CH4methane combustion at 400℃ and retained a high CH4conversion efficiency even under exposure to 50 ppm SO2.Similarly,Ce0.6Zr0.4O2or Sm2O3shell also demonstrated comparable SO2resistance.Detailed characterization results revealed that CeO2acted as an exceptional redox center,significantly enhanced SO2adsorption,and effectively inhibited the poisoning of the active PdO sites by SO2,leading to a notable improvement in sulfur dioxide tolerance.These findings highlighted the critical role of the core-shell structure in enhancing catalyst resistance to SO2poisoning during methane combustion.The present work provides valuable insights into the appropriate designing of advanced core-shell catalysts with improved durability and performance in the sulfur dioxide-containing environments. 展开更多
关键词 Methane combustion,core-shell structure Rare earth oxide modification Sulicate-1-supported pd catalyst SO2resistance
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Phosphorus modification-induced dense crystalline-amorphous heterostructured P-Sn6O4(OH)4@RGO for high-rate and ultra-stable lithium storage 认领 引用
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作者 Zhen Kong Chaoyang Sun +9 位作者 Mingyuan Pang Wei Liu Haohao Zhang Min Yang Jiajia Ye Juan An Yijie Wang Yen Leng Pak Xing Gao Jibin Song 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期637-643,共7页
The large volume expansion and rapid capacity attenuation of tin-based electrodes are the main factors limiting their commercial application.The reasonable design of electrode material structure is particularly import... The large volume expansion and rapid capacity attenuation of tin-based electrodes are the main factors limiting their commercial application.The reasonable design of electrode material structure is particularly important for improving its electrochemical performance.Herein,phosphorus-modified graphene encapsulated Sn6O4(OH)4nanoparticles composite(P-Sn6O4(OH)4@RGO)with crystalline-amorphous heterostructure has been successfully designed and prepared.The design of crystalline-amorphous structure has largely enhanced the active sites,and the construction of a graphene encapsulation structure has greatly alleviated volume expansion.Notably,P-Sn6O4(OH)4@RGO obtained an excellent high-rate longterm cycling performance for lithium-ion batteries anode,reaching a high specific capacity of 970 m Ah/g at 1.0 A/g after 1450 cycles.This work demonstrates that restructuring the electrode material's structure and phase through phosphorus modification can effectively improve the electrochemical performance of tin-based electrode materials. 展开更多
关键词 Phosphorus modification P-Sn6O4(OH)4@RGO Crystalline-amorphous heterostructure Graphene encapsulation structure Lithium-ion batteries
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Corrigendum to “Enhancing the stability of 68Ga-labeled RNA aptamers for pancreatic β-cell and insulinoma imaging through nucleoside modifications” [Chinese Chemical Letters 36 (2025) 110804] 认领 引用
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作者 Zhe Li Haozhi Lei +3 位作者 Zhiqiang Ren Cheng Wang Qian Xia Weihong Tan 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期800-802,共3页
The authors regret that during reviewing the published data,we identified an inadvertent image misplacement in Fig.2.Fig.2b presents the serum stability electrophoresis result of the RNA aptamer 1-717,whereas Fig.2d s... The authors regret that during reviewing the published data,we identified an inadvertent image misplacement in Fig.2.Fig.2b presents the serum stability electrophoresis result of the RNA aptamer 1-717,whereas Fig.2d shows the corresponding result for the RNA aptamer m12-3773.Because the two aptamers have similar lengths(1-717 contains 40 bases and m12-3773 contains 44 bases)and exhibited highly comparable serum stability profiles,resulting in the erroneous reuse of the Fig.2d image in Fig.2b. 展开更多
关键词 RNA aptamers nucleoside modifications pancreatic cell imaging serum stability profilesresulting image misplacement insulinoma imaging serum stability electrophoresis serum stability
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Phytomedicine-mediated time-dependent inactivation of CYP3A4 by chemical modification 认领 引用
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作者 Xu Mao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期656-667,共12页
Cytochromes P450(CYP)3A4 as the richest P450 enzyme is responsible for the metabolism of about 50%drugs.However,severe drug-drug interactions(DDIs)frequently occur when CYP3A4 is strongly inhibited by xenobiotics,whic... Cytochromes P450(CYP)3A4 as the richest P450 enzyme is responsible for the metabolism of about 50%drugs.However,severe drug-drug interactions(DDIs)frequently occur when CYP3A4 is strongly inhibited by xenobiotics,which is one of the major reasons for the withdrawal of already marketed drugs.Compared to reversible inhibition,time-dependent inactivation(TDI),including mechanismbased inactivation(MBI),quasi-irreversible inactivation,and affinity-labeling inactivation,results from chemical modification of the host enzyme by electrophilic inactivators or electrophilic intermediates and is more likely to result in adverse clinical consequences.Increasing phytomedicines have been identified as time-dependent inactivators of CYP3A4 with the rapid growth of global consumption of natural products.According to vast experimental and theoretical studies,functional groups with chemical reactivity existing in phytomedicines are mainly involved in TDI of CYP3A4.For better understanding of the structure-activity relationship between phytomedicine and CYP3A4,we systematically summarize chemical mechanisms of TDI,including furan,thiophene,acetylenes,and methylenedioxyphenyl(MDP)-containing phytomedicine-induced MBI,MDP,alkylamine,and hydrazine-containing phytomedicineinduced quasi-irreversible inactivation,and iminium-containing phytomedicine-induced affinitylabeling inactivation,and comprehensively classify known natural CYP3A4 time-dependent inactivators,including polyphenols,alkaloids,terpenoids,and coumarins,which will offer the guidance and evidence for rational drug combinations and avoid TDI-based DDIs in clinics. 展开更多
关键词 Time-dependent inactivation CYP3A4 Phytomedicine Chemical modification
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An empirical study on cross-phase code modification behaviors in incremental programming projects 认领 引用
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作者 Jing Jiang Chenhong Ji +1 位作者 Li Zhang Haiyan Yang 《计算机教育》 2026年第6期280-291,共12页
This paper conducts an empirical study on students'code modification behaviors in incremental programming projects by analyzing 40771 code submissions from 371 students through abstract syntax tree(AST)difference ... This paper conducts an empirical study on students'code modification behaviors in incremental programming projects by analyzing 40771 code submissions from 371 students through abstract syntax tree(AST)difference analysis and manual annotation.The study investigates the distribution of code modification types to prior-phase code during iterative development,identifies cross-phase error types,and analyzes refactoring strategies.The findings reveal that error correction and code refactoring constitute the primary types of cross-phase code modifications.Among cross-phase latent errors,special case neglect represents the dominant error type,indicating insufficient coverage of special scenarios in existing test suites.Variable renaming emerges as the most prevalent refactoring behavior,reflecting students'emphasis on code readability.These research findings provide empirical evidence for optimizing incremental curriculum design,improving test cases,and cultivating students'code maintenance capabilities in programming education. 展开更多
关键词 Incremental projects Code modification Error correction Code refactoring Computer science education
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Mass spectrometry analysis reveals changes in patterns and correlations of nucleic acid epigenetic modifications in mouse tissues exposed to polystyrene microplastics 认领 引用 被引量：1
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作者 Tian Feng Shu-Yi Gu +2 位作者 Lu-Fei Shi Yao-Hua Gu Bi-Feng Yuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期418-423,共6页
Microplastics(MPs),which originate from plastic degradation,are becoming a significant environmental pollutant,and their prevalence is increasing rapidly.Humans can ingest MPs through various pathways and their presen... Microplastics(MPs),which originate from plastic degradation,are becoming a significant environmental pollutant,and their prevalence is increasing rapidly.Humans can ingest MPs through various pathways and their presence has been detected in multiple human organs,raising concerns about the potential toxic effects associated with plastic consumption.Epigenetic modifications of nucleic acids play crucial roles in various biological processes,including gene expression and tumorigenesis.Previous studies have demonstrated that exposure to certain environmental pollutants can influence disease pathogenesis by affecting epigenetic factors,including modifications of nucleic acids.However,the impact of MPs on epigenetic modifications of nucleic acids remains largely unexplored.In this study,we systematically investigated the alterations in epigenetic modifications of DNA and RNA following exposure to polystyrene microplastics(PS-MPs).We utilized liquid chromatography-tandem mass spectrometry(LCMS/MS)to simultaneously analyze two DNA epigenetic modifications of 5-methylcytosine(5m C)and 5-hydroxymethylcytosine(5hm C),along with twenty RNA epigenetic modifications from small RNA and nine epigenetic modifications from m RNA.We measured changes in the levels of DNA and RNA modifications across six tissues(heart,liver,spleen,lung,kidney,and intestine)in mice after PS-MPs exposure.The results indicated that exposure to PS-MPs significantly altered the landscape of epigenetic modifications in nucleic acids.Furthermore,we observed tissue-specific effects,suggesting that different organs respond uniquely to PS-MPs exposure.Additionally,the correlation patterns between DNA and RNA modifications changed following PS-MPs exposure.These findings provide valuable insights suggesting that PS-MPs exposure may alter the patterns of epigenetic modifications in nucleic acids,potentially leading to adverse health effects. 展开更多
关键词 Polystyrene microplastics Exposure Epigenetics Mass spectrometry DNA modification RNA modification
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A high-energy powder with excellent combustion reaction performance:Surface modification strategy of boron powder based on non-thermal plasma 认领 引用 被引量：1
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作者 Kangkang Li Jianyong Xu +9 位作者 Xiaoting Lei Mengzhe Yang Jing Liu Luqi Guo Pengfei Cui Dihua Ouyang Chunpei Yu He Cheng Jiahai Ye Wenchao Zhang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第1期289-300,共12页
The presence of a surface oxide film(B2O3)on boron(B)particles significantly compromises their combustion efficiency and kinetic performance in fuel-rich solid propellants.This study proposes an innovative conti... The presence of a surface oxide film(B2O3)on boron(B)particles significantly compromises their combustion efficiency and kinetic performance in fuel-rich solid propellants.This study proposes an innovative continuous modification strategy combining non-thermal plasma(NTP)etching with fluorocarbon passivation.Characterization and kinetic analysis revealed that reactive plasma species—including atomic hydrogen(H),electronically excited molecular hydrogen(H2*),vibrationally excited molecular hydrogen(H2v),and hydrogen ions(H+)—dominate the reduction of B2O3through lowering the transition energy barrier and shifting the reaction spontaneity.Subsequent argon plasma fragmentation of C8F18generates fluorocarbon radicals that form conformal passivation coatings(thickness:7 nm)on purified boron surfaces.The modified boron particles exhibit 37.5℃lower exothermic peak temperature and 27.2%higher heat release(14.8 kJ/g vs.11.6 kJ/g)compared to untreated counterparts.Combustion diagnostics reveal 194%increase in maximum flame height(135.10 mm vs.46.03 mm)and 134%enhancement in flame propagation rate(4.44 cm/s vs.1.90 cm/s).This NTP-based surface engineering approach establishes a scalable pathway for developing highperformance boron-based energetic composites. 展开更多
关键词 Oxide film materials Surface modification Boron powder Non-thermal plasma Combustion performance
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Research Progress on Halide Solid-State Electrolytes:Synthesis,Mechanism,and Modification 认领 引用
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作者 Weifeng Shen Ping Liu +18 位作者 Long Wang Haijun Yang Jiawen Chen Fengxiang Chen Shenghui Shen Guoxiang Pan Zhong Qiu Xinqi Liang Yongqi Zhang Jiayuan Xiang Ming Song Wei Wen Ruyi Fang Hui Huang Jun Zhang Qi Liu Yang Xia Wenkui Zhang Xinhui Xia 《Carbon Energy》 SCIE EI CAS CSCD 2026年第4期167-194,共28页
Halide solid-state electrolytes(HSSEs)have gained significant attention as key components for all-solid-state lithium ion batteries due to their notable advantages,including high ionic conductivity(>1 m S cm-1),... Halide solid-state electrolytes(HSSEs)have gained significant attention as key components for all-solid-state lithium ion batteries due to their notable advantages,including high ionic conductivity(>1 m S cm-1),wide electrochemical window(>4 V vs.Li/Li+),and good compatibility with high-voltage cathodes.Despite progress,major challenges such as ionic conductivity,air stability,and interface compatibility still remain.This review systematically summarizes their representative classifications(e.g.,Lia-M-X8,Lia-M-X6,Lia-M-X4,LiaMbOcXd,M=In,Y,Al…;X=Cl,F,Br…),synthesis methods(e.g.,solid phase,liquid phase,gas phase),and ion conduction mechanisms(e.g.,vacancy-driven transport).The merits and demerits of different synthesis methods are analyzed,and the factors affecting ion conductivity are also discussed.Moreover,various modification strategies(e.g.,structure optimization,doping,and surface coating)are analyzed to address the above issues.Meanwhile,research guidelines for developing advanced HSSEs are also proposed.Additionally,we provide a systematic outlook on HSSEs in terms of novel synthesis methods and interface modification technologies(such as plasma and supercritical fluid technologies),high-precision characterization methods for interface components(such as solid-state nuclear magnetic resonance),artificial intelligence(AI)-assisted mechanism analysis,and material synthesis.This review offers new research insights into the design and development of advanced solid-state electrolytes for energy storage. 展开更多
关键词 halides interface modification mechanism solid-state electrolyte synthesis
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Advances in modification approaches for Mg-based hydrogen storage materials 认领 引用
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作者 CHENG Shuang LI Fei +6 位作者 WANG Yuqi WANG Xiangyi GUAN Sinan WANG Yi WANG Yue OU Guancheng XU Ming 《燃料化学学报（中英文）》 EI CAS CSCD 北大核心 2026年第2期46-63,共18页
As one of the most promising new energy sources,hydrogen energy is expected to usher in a full-fledged“hydrogen economy”in the 21st century.Compared with traditional high-pressure gaseous and cryogenic liquid hydrog... As one of the most promising new energy sources,hydrogen energy is expected to usher in a full-fledged“hydrogen economy”in the 21st century.Compared with traditional high-pressure gaseous and cryogenic liquid hydrogen storage methods,solid-state chemical hydrogen storage shows significant advantages in safety,high efficiency,and cost-effectiveness.Magnesium-based lightweight hydrogen storage materials have attracted widespread attention due to their high gravimetric hydrogen storage density(7.6%)and favorable reversibility.However,their sluggish reaction kinetics and stringent operating conditions(with H2 release temperatures exceeding 350°C and H2 absorption pressures above 4 MPa)pose major challenges for practical applications.Domestic and international researchers have conducted in-depth studies to address these issues,achieving substantial progress in the modification of magnesium-based hydrogen storage alloys.This paper systematically elaborates on major modification techniques such as alloying,nanostructuring,and catalytic material doping,providing a comprehensive analysis of the strengths and limitations of each approach.Furthermore,it offers prospects for the future development of magnesium-based hydrogen storage materials by integrating current theoretical and experimental research findings. 展开更多
关键词 magnesium hydride solid-state hydrogen storage modification kinetics thermodynamics
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Reducing bentonite usage in iron ore pelletization through synergistic modification with mechanical force and DMSO:Effects and mechanisms 认领 引用
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作者 Yinrui Dong Yongbin Yang +4 位作者 Lin Wang Qianqian Duan Qian Li Yan Zhang Tao Jiang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第1期177-190,共14页
Bentonite is a necessary binder in producing pellets.Its excessive use reduces the iron grade of pellets and increases production costs.Minimizing bentonite dosage is essential for producing high-quality iron ore pell... Bentonite is a necessary binder in producing pellets.Its excessive use reduces the iron grade of pellets and increases production costs.Minimizing bentonite dosage is essential for producing high-quality iron ore pellets.Addressing the gap in the application of organically-intercalated modified bentonite in the pelletizing field,this study introduces an innovative modification process for bentonite that employs the synergistic effect of mechanical force and dimethyl sulfoxide to enhance the intercalation of organic compounds within bentonite,thus significantly enhancing its binding performance.The colloid value and swell capacity of modified bentonite(98.5 m L/3g and 55.0 m L/g)were much higher than the original bentonite(90.5 m L/3g and 17.5 m L/g).With the decrease of bentonite dosage from1.5wt%to 1.0wt%,the drop number of green pellets from a height of 0.5 m and the compressive strengths of roasted pellets using the modified bentonite(6.0 times and 2916 N per pellet)were significantly higher than those of the original bentonite(4.0 times and 2739 N per pellet).This study provides a comprehensive analysis of the intercalation modification mechanism of bentonite,offering crucial technical insights for the development of high-performance modified bentonite as iron ore pellet binders. 展开更多
关键词 pellets bentonite modification mechanical force dimethyl sulfoxide organic intercalation
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