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A survey of panel aeroelasticity in shock-dominated flow:Perspectives from fluid-structure interactions and shock wave-boundary layer interactions 认领 引用 被引量：1
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作者 Aiming SHI Yiwen HE 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第1期210-229,共20页
As a multidisciplinary phenomenon,panel aeroelasticity in shock-dominated flow is featured by two primary interactions:Fluid-Structure Interactions(FSIs)and Shock-Boundary Layer Interactions(SBLIs).The former raises s... As a multidisciplinary phenomenon,panel aeroelasticity in shock-dominated flow is featured by two primary interactions:Fluid-Structure Interactions(FSIs)and Shock-Boundary Layer Interactions(SBLIs).The former raises structural concerns,and the latter is of aerodynamic interest.Thus,panel aeroelasticity in shock-dominated flow represents a vital topic for the development and optimization of supersonic vehicles and propulsion systems.This review systematically summarizes recent advances in the methodologies applied to capture structural and fluid dynamics,including theoretical models,numerical simulations,and wind tunnel experiments.The application of data-driven modal decomposition,an advanced technique to extract physically crucial features,on the topic is introduced.From the perspective of FSIs,the distinctive aeroelastic behaviors in shock-dominated flow,including hysteresis phenomena and nonlinear responses,are highlighted.From the perspective of SBLIs,the modifications in their spatial and temporal characteristics imposed by the aeroelastic responses are emphasized.Motivated by the interaction between the shock waves and structural response,different strategies have been proposed to implement aeroelastic suppression and shock control,which have the potential to enhance structural safety and aerodynamic performance in the next generation of high-speed flight vehicles. 展开更多
关键词 Aeroelasticity Fluid structure interaction Modal decomposition Shock boundary layer interactions Shock waves
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Studies and analysis of drug-target interactions by affinity chromatography and related techniques:A review 认领 引用 被引量：1
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作者 David S.Hage Sadia Sharmeen +5 位作者 B.K.Sajeeb Harshana Olupathage Md Masudur Rahman Isaac Kyei Samiul Alim Nigar Sultana Pinky 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期330-346,共17页
The characterization of drug-target interactions is a key component of drug discovery,testing,and development.Affinity chromatography is one approach that can be used for this type of analysis.For instance,this may be... The characterization of drug-target interactions is a key component of drug discovery,testing,and development.Affinity chromatography is one approach that can be used for this type of analysis.For instance,this may be done by using an immobilized target as a stationary phase and a drug as the applied solute.This review will discuss the various ways in which affinity chromatographic methods have been used to examine drug-target interactions,with an emphasis on high-performance methods.The general principles of this approach and factors to consider in its use for drug-target interaction analysis will first be examined.Methods based on zonal elution or frontal analysis for binding and competition studies will then be discussed.Various techniques for kinetic studies will next be considered,along with approaches that employ secondary binding agents and hybrid techniques.In each case,the general principles and theory of an approach will be given along with examples of its use in drug-target interaction studies.Advantages or limitations of each approach will be provided as well.This information should make it possible in the future to extend these techniques to other drug-target systems of interest in biomedical research and drug testing or development. 展开更多
关键词 Affinity chromatography High-performance affinity chromatography Drug-target interactions Drug-protein binding Kinetic analysis Biointeraction analysis
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Breaking the boundaries of affinity selection-mass spectrometry:From ligand screening to target-ligand interaction insights 认领 引用 被引量：1
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作者 Pamella Christina Ortega de Oliveira Bruno Sergio do Amaral +2 位作者 Carmen Lucia Cardoso Quezia Bezerra Cass Marcela Cristina De Moraes 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期347-358,共12页
Affinity selection mass spectrometry(AS-MS)has emerged as a powerful label-free technique for identifying and characterizing ligand-target interactions.This review explores the diverse applications of AS-MS in drug di... Affinity selection mass spectrometry(AS-MS)has emerged as a powerful label-free technique for identifying and characterizing ligand-target interactions.This review explores the diverse applications of AS-MS in drug discovery,including its role in selective screening,binding site characterization,and quantitative affinity determination.We discuss the use of AS-MS for determining equilibrium dissociation constants(KD)and competitive binding parameters(affinity competition experiment 50%(ACE50)),highlighting its ability to rank ligand affinities efficiently.The review also examines AS-MS applications in fragment-based drug discovery(FBDD),screening for molecular glues,and investigating interactions with membrane proteins.Moreover,we address key technical challenges,including competitive binding effects,protein stability,and ligand dissociation kinetics,along with recent advancements in automation and artificial intelligence(AI)integration.Rather than providing a comprehensive literature review,this work aims to broaden the applicability of AS-MS assays and encourage researchers to explore its use in underutilized contexts.By providing rapid and high-sensitivity affinity measurements,AS-MS continues to expand its role in drug discovery and structural biology,complementing conventional biophysical techniques. 展开更多
关键词 Affinity selection mass spectrometry Competition assays Drug discovery Fragment screening KD determination Ligand-target interactions Molecular glues
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Human‑robot interaction design with augmented reality in construction:A systematic review of frameworks,applications,and future directions 认领 引用
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作者 Tan TAN Xin LIU +2 位作者 Alexander N.WALZER Ming Shan NG Daniel M.HALL 《ENGINEERING Management》 CSCD 2026年第1期85-104,共20页
Research in human‑robot Interaction(HRI)has increasingly demonstrated how Augmented Reality(AR)enables better interactions between humans and robots.However,the design of HRI remains less understood.Through a systemat... Research in human‑robot Interaction(HRI)has increasingly demonstrated how Augmented Reality(AR)enables better interactions between humans and robots.However,the design of HRI remains less understood.Through a systematic literature review of 53 related papers,this research provides an overview of the emerging applications and trends for AR and identifies three types of AR interfaces as follows:1)remote modular interface,2)proximal modular interface,and 3)proximal integral interface.The review indicates potential future directions of construction‑oriented and human‑centric interaction design studies,leading to four pairs of subsystems,which are frequently modularised or integrated,and three conceptual frameworks for HRI interfaces are proposed.Moreover,this research contributes to the theoretical exploration of interaction design.Future applications can adapt to various tasks by using the proposed three conceptual frameworks for interfaces,as well as combining the four proposed subsystem pairs to suit specific task requirements in the construction sector. 展开更多
关键词 augmented reality human‑robot interaction interaction design human‑computer interaction literature review
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A Review on Circumferential Crack Method Used for Simulating Ice-Structure Interaction 认领 引用 被引量：3
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作者 ZHOU Li 《China Ocean Engineering》 SCIE EI CSCD 2026年第1期1-14,共14页
Structure-ice interaction problems have attracted increasing attention,yet accurately predicting the loads exerted by sea ice on ship hulls remains a significant challenge.Over the past few decades,various numerical m... Structure-ice interaction problems have attracted increasing attention,yet accurately predicting the loads exerted by sea ice on ship hulls remains a significant challenge.Over the past few decades,various numerical methods have been employed to simulate ice resistance on ships and evaluate their manoeuvrability during ice-structure interaction.Among these approaches,the circumferential crack method has demonstrated both high efficiency and accuracy.This paper provides a detailed introduction to the fundamental theory of this method,including the numerical modeling of different failure modes and the dynamic ice motion responses.Furthermore,it reviews existing studies on predicting ice resistance and assessing the manoeuvrability of icebreakers navigating through ice-covered regions using the circumferential crack method.Several recommendations for future research in this field are also presented. 展开更多
关键词 ice forces circumferential crack method ice resistance ice-structure interaction ice failure modes polar ship
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Host-guest interaction mediated low-shrinkage photosensitive positioning adhesive 认领 引用
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作者 Zhao Liu Junjian Xie +3 位作者 Xiaoming Ren Muhammad Tahir Shixin Fa Qiuyu Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期501-504,共4页
As a common electronic adhesive,ultraviolet(UV)curing polyurethane acrylate adhesive has both flexibility and wear resistance of polyurethane,excellent weather resistance and optical properties of acrylate.Despite the... As a common electronic adhesive,ultraviolet(UV)curing polyurethane acrylate adhesive has both flexibility and wear resistance of polyurethane,excellent weather resistance and optical properties of acrylate.Despite the extensive applications,it is still difficult to solve the problems caused by the shrinkage of adhesive.Here,a new type of photosensitive adhesive for bonding electronic components based on supramolecular interaction was designed and synthesized.The supramolecular interaction of cyclodextrin and adamantane moieties introduced into the adhesive polymer entitles the viscosity of the adhesive to rise rapidly during use,thereby preventing adhesive loss and dislocation of electronic components.UV light could further cure the adhesive and position the electronic components.The adhesive shrunk<2%when cured by UV light,so it can be used for electronic packaging and high-resolution,defect-free lithography. 展开更多
关键词 Adhesive Host-guest interaction UV-curing Low-shrinkage Lithography
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Integrated multi-omics analysis unveils metabolites-mediated microbial interactions:dynamic regulation and metabolic division of A.flavus SU-16 and S.cerevisiae HJ during co-fermentation 认领 引用
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作者 Shuangping Liu Mingliang Li +5 位作者 Hailong Sun Zhuoyue Zheng Yuezheng Xu Xiao Han Zhilei Zhou Jian Mao 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1757-1773,共17页
This study aimed to gain insight into the interaction and metabolic mechanism between Aspergillus flavus U-16 and Saccharomyces cerevisiae HJ during co-fermentation.Despite the suppressed transcriptional activity of S... This study aimed to gain insight into the interaction and metabolic mechanism between Aspergillus flavus U-16 and Saccharomyces cerevisiae HJ during co-fermentation.Despite the suppressed transcriptional activity of SU-16,its metabolites exerted a pivotal regulatory influence.The metabolites produced by SU-16 significantly increased the ethanol content to 17.0%.They also significantly increased the contents of crucial flavor substances,including amino acids(at least 5 times)and esters(up to 1100 mg/L).SU-16 produced 130 metabolites that may affect flavor compounds,while HJ mainly controlled the synthesis of 161 compounds.Metabolites of SU-16 with different molecular weights were observed to exert differential regulatory effects on the fermentation process and the metabolic pathway of HJ.The small molecule metabolites of SU-16 promoted the growth of HJ significantly.In contrast,its macromolecular metabolites were found to mainly affect the expression of genes related to carbohydrate and amino acid metabolism in the HJ genome. 展开更多
关键词 Co-fermentation Metabolites Interaction Dual RNA-seq Transcriptomic Metabolomics
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Polypharmacy in Elderly Patients Receiving First-Line Treatment for Pancreatic Adenocarcinoma:Analysis of Potential Drug–Drug Interactions and Outcome 认领 引用
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作者 Stefano Vecchia Rebecca Chinelli +3 位作者 Arianna Orcesi Chiara Citterio Alessandra Riva Elena Orlandi 《Oncology Research》 SCIE 2026年第6期444-456,共13页
Objectives:Pancreatic ductal adenocarcinoma(PDAC)is a leading cause of cancer-related mortality and mainly affects older adults,who frequently experience polypharmacy.While systemic therapy may improve outcomes in sel... Objectives:Pancreatic ductal adenocarcinoma(PDAC)is a leading cause of cancer-related mortality and mainly affects older adults,who frequently experience polypharmacy.While systemic therapy may improve outcomes in selected older patients,the use of multiple drugs increases the risk of potential drug–drug interactions(pDDIs).This study aimed to evaluate the prevalence and characteristics of pDDIs in older patients with PDAC receiving first-line systemic therapy and their potential impact on clinical outcomes.Methods:We conducted a retrospective single-center study including patients aged≥75 years with PDAC who initiated first-line systemic therapy between December 2011 and January 2023.Prescription data were retrieved from institutional and outpatient pharmacy databases,and all concomitant medications were recorded.pDDIs were assessed using Intercheck Web and classified as A(minor),B(moderate),C(major but manageable),or D(contraindicated).Patients(n=140)were stratified according to the number of active pharmaceutical ingredients(APIs)at treatment initiation:20(n=44).Results:A higher number of APIs was significantly associated with an increased burden of pDDIs,including A,B,C,and D interactions(all p20 APIs showing the highest prevalence of clinically relevant interactions.Overall,70%of patients had at least one pDDI,but no significant differences were observed in 1-year overall survival,access to second-line therapy,or chemotherapy type across API groups.Conclusion:Polypharmacy significantly increases the risk of pDDIs in older patients with PDAC,but this did not translate into differences in 1-year survival or access to subsequent therapy. 展开更多
关键词 Drug-drug interaction pancreatic adenocarcinoma pharmacology oncology
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Gene-Environment Interaction of Rims1 and Adolescent Social Isolation on Schizophrenia-Like Behaviors in Mice 认领 引用
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作者 Lian-Hong Lin Wei-Min Li +6 位作者 Qian-Yun Wu Shuang-Yan Li Xu-Xuan Ma Yuan Xu Si-Fu Deng Bin Zhang Ji-Hong Liu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第5期1021-1037,共17页
Schizophrenia(SCZ)is a severe mental illness influenced by gene-environment interactions(GEI).However,little is known about how GEI mediates SCZ.The present study aimed to examine the underlying mechanism of SCZ media... Schizophrenia(SCZ)is a severe mental illness influenced by gene-environment interactions(GEI).However,little is known about how GEI mediates SCZ.The present study aimed to examine the underlying mechanism of SCZ mediated by GEI.We found that a single environmental factor(two-week adolescent social isolation)or genetic factor(the heterozygous Rims1 knockout mice)did not induce SCZ-like behaviors.Interestingly,two-week adolescent social isolation successfully caused SCZ-like behaviors in heterozygous Rims1 knockout mice,which can be rescued by anti-SCZ drugs.RNA-seq analysis further revealed that synaptic vesicle-related biological processes and target genes were enriched in the hippocampus of GEI animal model mice,which was accompanied by disturbed excitatory synaptic neurotransmission.Finally,the Nrg1 gene was decreased in our RNA-seq analysis,and supplementation of Nrg1 ameliorated SCZ-like behaviors in heterozygous Rims1 socially isolated mice.Our findings establish a novel GEI animal model and offer a potential therapeutic target in the treatment of SCZ. 展开更多
关键词 Schizophrenia Gene-environment interactions Animal model RNA-seq Nrg1
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“Dual sweet”supramolecular glycosyl-nanoproteins based on carbohydrate-protein interaction for targeted drug delivery in vivo 认领 引用
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作者 Kun Shang Yinghua Lv +8 位作者 Yibo Yang Senyu Yang Zelong Chen Ke Yang Cong Li Shuang Chao Yuchao Lu Yuxin Pei Zhichao Pei 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期371-379,共9页
Biomolecular self-assembly systems form the cornerstone of biological structures,in which the interactions between carbohydrates and proteins play a crucial role in many life processes.This has driven the development ... Biomolecular self-assembly systems form the cornerstone of biological structures,in which the interactions between carbohydrates and proteins play a crucial role in many life processes.This has driven the development of biomimetic carbohydrate-protein supramolecular assemblies(BCPSAs),which show great potential in biomedical research.We successfully constructed a novel supramolecular hybrid nanocarrier with pH responsiveness and targeting capabilities based on specific interactions between carbohydrates and proteins.This system self-assembles into nanoparticles CA@MP5 in water through the specific binding of mannose clusters on glycosylated pillar[5]arene MP5 with lectin Con A.Additionally,through a host-guest assembly strategy with the synthesized β-D-galactopyranosyl pyridine derivative G,it complexes within the MP5 cavity to form a"double-sweet"supramolecular glyco-nanoprotein(CA@MP5⊃G).This system shows high affinity for the asialoglycoprotein receptor(ASGPR)on HepG2 liver cancer cells.In vitro,the doxorubicin(DOX)-loaded micelles(DCA@MP5⊃G)release drug effectively in acidic environments and significantly inhibit HepG2 cell growth,with reduced toxicity toward normal cells.In vivo,the nanocarrier targets tumors effectively,reducing systemic toxicity and inhibiting tumor growth.This study offers a novel construction strategy for drug delivery systems based on carbohydrate-protein interactions in anti-tumor applications,which is significant for enhancing therapeutic efficacy. 展开更多
关键词 Carbohydrate-protein interactions Glycosyl-nanoproteins Supramolecular self-assembly Drug-targeted delivery Chemotherapy
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Bibliometric review of human-flood interaction:Geospatial disconnects between hazard patterns and scientific knowledge 认领 引用
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作者 Zhiyang Lan Wenbin Liu +5 位作者 Xinli Bai Tingting Wang Hong Wang Yao Feng Yusen Yang Fubao Sun 《Geography and Sustainability》 CSCD 2026年第2期19-29,共11页
Amid accelerating climate change and intensifying human activities,flood risks have been accumulating,rein forcing the bidirectional interplay between humans and floods.Within this context,human-flood interaction has ... Amid accelerating climate change and intensifying human activities,flood risks have been accumulating,rein forcing the bidirectional interplay between humans and floods.Within this context,human-flood interaction has emerged as a rapidly expanding research frontier that is attracting growing attention.Here,we review 78 rep resentative studies to examine publication trends,research hotspot shifts,and persistent challenges in this field,combining bibliometric analyses with flood disaster records.We found that,over the past three decades,publica tions on human-flood interaction have increased exponentially,with their focus shifting from one-way impacts towards two-way human-flood coupling.The global collaboration network displays a“dual-core”structure,with transcontinental collaboration between China and the United States and regional collaborations within Europe,whereas participation from Global South countries remains marginal.In addition,a spatial disconnect persists between the geographic distribution of research hotspot regions and that of flood records.Based on bibliometric mapping,we further highlight three enduring challenges:(i)scale mismatches,(ii)spatiotemporal coupling gaps,and(iii)deficits in behavioral modeling.The insights gained from this study will help guide future research and investment in human-flood interaction,with practical implications for enhancing resilience to flood disasters and promoting sustainable human-water coexistence. 展开更多
关键词 Human-flood interaction Bibliometric analysis Coupling gap
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Molecular interactions and dynamics of microplastics in indoor dust with lung-inflammatory receptors:A study in academic settings 认领 引用
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作者 Aswin Kuttykattil Shiv Basant Kumar +5 位作者 Jey Kumar Pachiyappan Sudharsanavasan Chandrasekar Sudhakaran Raja Rajendran Selvakumar Gowthamarajan Kuppusamy Thava Palanisami 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第3期384-390,共7页
Airborne microplastics(MPs)are prevalent indoors,and due to their low aerodynamic diameter,they can be inhaled,posing potential health risks.Although the toxic effects of airborne MPs have been explored using in vivo ... Airborne microplastics(MPs)are prevalent indoors,and due to their low aerodynamic diameter,they can be inhaled,posing potential health risks.Although the toxic effects of airborne MPs have been explored using in vivo and in vitro models,the interactions between MPs and cellular receptors remain understudied.In this research,dust samples from a confined space within an academic setting were investigated for microplastics(MPs)and their abundance.Further,the most prevalent microplastics were used to study receptor binding and competition interaction studies using the In-Silico method against natural agonists and antagonists of major inflammatory receptors,including the human platelet-activating factor receptor(PAFR),C-X-C motif chemokine receptor 1(CXCR1),β2-adrenergic receptor(β2-AR),and toll-like receptor 2(TLR-2).Results revealed that polyester(PE)was the predominant polymer,accounting for 23.96%of the samples.Analysis indicated that a monomer of PET,Ethylene Terephthalate(ET),exhibited a high binding affinity of-6.5 kcal/mol with the PAFR receptor.Additionally,the molecular dynamics and protein-ligand interaction study,which involves hydrogen bonding,explains the differential binding effect of ET and the control compound with the targeted receptor.The complex was formed between the ET and the receptors ofβ2-AR,CXCR1,and TLR-2,with a maximum of seven and a minimum of one hydrogen bond throughout the simulation.This research lays a foundation for understanding the potential health implications of MPs in confined office spaces,underscoring the need for further in vivo and in vitro examinations. 展开更多
关键词 Indoor dust Airborne Microplastics Polyester-receptor interaction In silico
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Boosting output performance in hydrogel-based moisture-electric generators via tunable solvent interactions 认领 引用
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作者 Xingyi Dai Jiaxin Han +5 位作者 Yifei Zhao Weng Fu Io Xuyang Zhang Biqin Dong Long-Biao Huang Jianhua Hao 《Science China Materials》 SCIE EI CAS CSCD 2026年第8期4756-4765,共10页
Hydrogels,with their hydrophilicity,flexibility,and environmental friendliness,are highly desirable for moisture-electric generators(MEGs)that harness ubiquitous moisture to generate electrical energy.As the active ma... Hydrogels,with their hydrophilicity,flexibility,and environmental friendliness,are highly desirable for moisture-electric generators(MEGs)that harness ubiquitous moisture to generate electrical energy.As the active material layer in MEGs,hydrogels play a crucial role in absorbing atmospheric moisture and converting chemical potential energy into electricity.However,the relatively low output current of the device and the instability of hydrogels pose challenges to the development of high-performance hydrogel-based MEGs.Herein,we introduce a straightforward,feasible,cost-effective,and versatile two-step solvent displacement strategy to overcome the barrier associated with the development of MEGs.Through tunable solvent interactions of glycerol and water,the moisture absorption capability and stability of the hydrogel can be improved,while promoting favorable ion migration.Such an effective processing route not only significantly boosts the output performances but also greatly improves the long-term durability of hydrogel-based MEGs.Notably,the current output and power density of the treated MEGs can increase by up to two orders of magnitude.The mechanisms behind the intriguing observation are investigated by various characterizations and theoretical calculations.This universal strategy holds promise to be extended to various hydrogel-based MEGs.Moreover,the MEGs can be used for energy harvesting,self-powered respiratory monitoring,and non-contact humidity detection.This work offers new opportunities for advancing green energy and self-powered technologies. 展开更多
关键词 moisture-electric generator hydrogel solvent interaction output enhancement self-powered sensor
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Dynamic Supramolecular Polymer Networks Constructed by Synergistic Dual Host-Guest Interactions 认领 引用
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作者 Hui Li Yan Dong +3 位作者 Sheng-Yong Liu Ju-An Zhang Zhe-Lin Zhang Wei Tian 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第7期2034-2042,共9页
The cross-linked structure plays a decisive role in determining the mechanical properties of polymer materials.Although various supramolecular polymer networks(SPNs)based on noncovalent bonds have been developed,few s... The cross-linked structure plays a decisive role in determining the mechanical properties of polymer materials.Although various supramolecular polymer networks(SPNs)based on noncovalent bonds have been developed,few studies have focused on constructing SPNs through dual host-guest interactions between macro-and small-molecular building blocks.Herein,we utilized these building blocks to prepare SPNs aimed at addressing this gap.Specifically,the supramolecular polymer network SPN-EF was prepared through crown ether and pillararenebased dual host-guest interactions.Compared to the control systems SPN-AC and SPN-BD,which incorporate only single type of host-guest interaction(based on either crown ether or pillararene),the SPN-EF integrate the advantages of both systems,exhibiting balanced and enhanced mechanical properties.Moreover,the resulting SPN gels retain significant dynamic properties,including excellent self-healing capability and stimuliresponsiveness. 展开更多
关键词 Supramolecular polymer network Double host-guest interactions Stimuli-responsiveness
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Mechanical behavior and damage constitutive model of silty mudstone under thermo-hydro-mechanical interactions 认领 引用
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作者 ZENG Ling CHENG Hui +6 位作者 SONG Jianping XIONG Jianping ZHANG Hongri CHEN Jingcheng WANG Wenguang LI Youjun LIU Jie 《Journal of Mountain Science》 SCIE CSCD 2026年第1期434-452,共19页
Understanding the deterioration behaviors and mechanisms of rocks under thermo-hydromechanical(THM)interactions is crucial for mitigating slope instability.In this study,the physicomechanical properties of silty mudst... Understanding the deterioration behaviors and mechanisms of rocks under thermo-hydromechanical(THM)interactions is crucial for mitigating slope instability.In this study,the physicomechanical properties of silty mudstone subjected to THM interactions were investigated by triaxial tests.The underlying micro-mechanisms were revealed using microscopic tests.The triaxial test results indicate that the strength parameters of silty mudstone decrease by 89.50%(deformation modulus),78.15%(peak strength),70.58%(cohesion),and 48.65%(friction angle)under 16 THM cycles,a load of 300 kPa,and alternating between 0℃water immersion and 60℃drying.The SEM test results indicate that the deterioration of silty mudstone strength primarily results from hydrothermal-expansion softening and cracking driven by the TLHM interactions.The specimens manifest shear failure under confining pressure exceeding 140 kPa.Furthermore,a new constitutive model considering hydrothermalexpansion strain and non-linear deformation characteristics was developed.The discrepancy between the experimentally measured peak strength and the damage constitutive model prediction remains below 5%.The proposed model is verified to be in satisfactory agreement with the experimental results.The self-designed THM apparatus overcomes the limitations of traditional investigations,enabling simultaneous consideration of thermal,hydraulic,and mechanical interactions. 展开更多
关键词 Silty mudstone THM interactions Mechanical properties Damage constitutive model
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Role of Multiscale Interactions within the Westerly Wind Bursts in MJO Prediction 认领 引用
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作者 Jian LING Yuanwen ZHANG Chongyin LI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2026年第3期489-503,共15页
This study reveals the critical role of multiscale interaction within the westerly wind bursts(WWBs)west of the MJO convection in modulating the prediction skill for the November MJO event during the DYNAMO(Dynamics o... This study reveals the critical role of multiscale interaction within the westerly wind bursts(WWBs)west of the MJO convection in modulating the prediction skill for the November MJO event during the DYNAMO(Dynamics of the Madden–Julian Oscillation)field campaign.The characteristics of the MJO convection envelope are obtained by the largescale precipitation tracking method,and a novel metric is introduced to quantify the prediction skill for the MJO convection in the ECMWF reforecast.The ECMWF forecast exhibits approximately 17 days in skillful prediction for the MJO convection—significantly lower than that derived from the global measure.The reforecast ensembles are further classified into high and low skill catalogs based on the mean prediction skill during the observed WWBs period.High-skill ensembles exhibit significantly enhanced low-level westerlies,amplified MJO convection,and reduced spatial separation between the low-level westerlies and MJO convection during the WWBs period,indicating stronger coupling between the large-scale circulation and the convection.Mechanistic analysis reveals that enhanced westerlies in high-skill ensembles can transfer more high-frequency energy to the MJO convection through the flux convergence of interaction energy for MJO convection development,resulting in better prediction skill. 展开更多
关键词 MJO convection envelope prediction multiscale interaction
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Real-time control for autoclave curing process of CFRP composites considering tool-part interaction 认领 引用
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作者 Wenyuan TANG Liang HE +4 位作者 Xinyu HUI Jianwen NIU Yingjie XU Rutong YANG Yutong LIU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第3期667-681,共15页
An integrated real-time control methodology is introduced to mitigate process-induced challenges,namely temperature overshoot,uneven cure,and interfacial shear stress,during the autoclave curing of Carbon Fiber-Reinfo... An integrated real-time control methodology is introduced to mitigate process-induced challenges,namely temperature overshoot,uneven cure,and interfacial shear stress,during the autoclave curing of Carbon Fiber-Reinforced Polymer(CFRP)composites.First,a high-fidelity Finite Element(FE)model incorporating tool-part interaction is developed to reveal the curing process of the composites,wherein the interaction is characterized by friction interface modeling with experimentally measured cure-dependent friction coefficients.The accuracy of FE model is confirmed through experimental tests on a doubly curved T-stiffened composite panel.This validated model then generates a dataset of curing temperature profile and associated defect information,which is used to train a customized Long Short-Term Memory(LSTM)neural network.We culminate in a real-time control framework that actively optimizes the curing process by integrating LSTM-based state prediction with Q-learning-driven decision logic.The optimized thermal profile demonstrates a clear performance enhancement over the traditional multi-dwell approach,achieving marked reductions in temperature difference,Degree of Cure(DoC)difference and tool-part interface shear stress,which provides more insights for intelligent composite manufacturing. 展开更多
关键词 CFRP composites Curing process Neural network Real-time optimization Tool-part interaction
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An aircell hydrogel for ultra-sensitive human-machine interaction 认领 引用
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作者 Minghao Li Haoxu Yu +4 位作者 Deliang Li Fujun Wang Yanling Tian Ye Tian Faze Chen 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期722-736,共15页
Porous hydrogel sensors have attracted significant attention in fields such as smart wearables and medical monitoring due to their high sensitivity.However,existing fabrication methods typically degrade the surface sm... Porous hydrogel sensors have attracted significant attention in fields such as smart wearables and medical monitoring due to their high sensitivity.However,existing fabrication methods typically degrade the surface smoothness of hydrogels when introducing porous structures and face significant challenges in removing fillers completely.To address these challenges,we herein introduce a novel one-step,thermosensitive spray-coating technique for the preparation of aircell hydrogel(ACH).This method leverages the rapid cooling of a thermoresponsive gelatin methacryloyl solution through atomization,enabling rapid cross-linking within seconds and air bubbles encapsulated in situ.Additionally,the transient flow of the pre-gel facilitates the repair of voids formed by ruptured surface bubbles,leading to the creation of the ACH with uniformly distributed inner air bubbles and a smooth outer surface.The mold-free fabrication method is independent of substrate surface properties,enabling the creation of a porous hydrogel film with a thickness as thin as 163 µm.Furthermore,the dual-crosslinked network endows the ACH with excellent anti-swelling properties,and the physical crosslinking between gelatin molecules allows the ACH to self-heal.The ACH exhibits excellent sensitivity in deformation sensing and can even successfully track minor external forces,which enables it to effectively complete various tasks such as facial expression recognition,pitch differentiation,and motion detection.By integrating the ACH into a sensing glove,we also demonstrate the significant potential of the ACH for applications in human-machine interaction and tactile sensing.Ultimately,the ACH sensors are also applied to motion mapping and machine tactile feedback,indicating their promising potential in human-machine interaction. 展开更多
关键词 flexible sensors spray atomization dual crosslinking human-machine interaction
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Metabarcoding of gut content reveals the trophic interactions and dietary breadth of an artificially released generalist predator in agricultural landscapes 认领 引用
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作者 Weidong Huang Pingzhou Zhu +7 位作者 Zening Wang Zihua Zhao Chunyan Yang Yuange Duan Jinhong Zhou Hu Li Zhenyuan Xia Wanzhi Cai 《Ecological Frontiers》 CSCD 2026年第1期317-324,共8页
A limited understanding of the feeding habits of ecosystem service providers is a notable obstacle to the deployment of natural enemies in pest management.Understanding the dietary diversity of predators can enhance c... A limited understanding of the feeding habits of ecosystem service providers is a notable obstacle to the deployment of natural enemies in pest management.Understanding the dietary diversity of predators can enhance conservation strategies and assess their effects on pest populations.In this study,we used metabarcoding of DNA extracted from the gut contents of an artificially released generalist predator,Eocanthecona furcellata,collected from tobacco cultivation fields in Yunnan Province,China.We aimed to investigate prey composition,selectivity,and efficiency of biological control.Among the individuals of E.furcellata,we detected diverse potential prey,comprising 53 insect species across 28 families and seven orders.Several agricultural pests,including Spodoptera exigua,S.litura,Helicoverpa armigera,and Agrotis segetum,were identified.Diptera are important in the diet of E.furcellata,with 22 species from 14 families accounting for 52.2%of the observed predation events.Eocanthecona furcellata consumed certain beneficial predators present in the tobacco fields,such as carabid beetles,hoverflies,wasps,and lacewings,although the incidence was generally low,except for Syrphidae.Our findings revealed previously unidentified trophic linkages involving E.furcellata with pest species and other biological control agents,as well as highlighting the critical role of neutral insects in shaping the dietary spectrum of E.furcellata in tobacco fields.This study establishes an important foundation for integrating metabarcoding technology into biological control research,particularly for elucidating trophic interactions between natural insect enemies and their prey. 展开更多
关键词 DNA metabarcoding Trophic interaction Biological control Agroecosystems Diet
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Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing 认领 引用
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作者 Haomin Wang Lei Yang +7 位作者 Hao Jiang Zheng Li Xiaojun Zhou Baokun Wang Zheyu Zhang Guoqing Wang Shuo Chen Chuanglong He 《Bioactive Materials》 SCIE CSCD 2026年第7期758-773,共16页
Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis.However,achieving such precise coordinatio... Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis.However,achieving such precise coordination with a single regenerative dressing remains a considerable challenge.Drawing inspiration from native skin physiology,we have developed an intelligent,conductive,skin-mimetic bilayer hydrogel that spatially segregates functions and temporally orchestrates the repair process.This design features a robust,anisotropic upper layer that provides protection and serves as an efficient conduit for electrical stimulation,combined with a responsive lower layer that adheres to the wound and enables on-demand drug delivery.Specifically,the lower hydrogel releases calcitonin gene-related peptide in response to the early inflammatory microenvironment,effectively suppressing the pro-inflammatory M1 macrophage phenotype and promoting its transition to the pro-repair M2 phenotype.Subsequently,the conductive upper layer sustains the release of magnesium ions and synergizes with electrical stimulation to significantly enhance endothelial cell migration and tube formation via activation of the VEGF signaling pathway.Transcriptomic analysis reveals that this combination fosters a pro-regenerative microenvironment by enriching pathways related to extracellular matrix organization and angiogenesis.This skin-mimetic structure-to-function design offers a practical strategy for staged,precise wound repair in diabetes and provides a generalizable framework for chronic tissue regeneration. 展开更多
关键词 Skin-mimetic Diabetic wound Neuro-immune interactions Angiogenesis and neurogenesis Time-sequential therapy
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