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Advanced Design for High-Performance and AI Chips 认领 引用 被引量：1
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作者 Ying Cao Yuejiao Chen +2 位作者 Xi Fan Hong Fu Bingang Xu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期306-336,共31页
Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI ... Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward. 展开更多
关键词 Artificial intelligence Advanced chips AI chips Design tactics Review and perspective
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Corrigendum to“Multi-functional photonic spin Hall effect sensor controlled by phase transition” 认领 引用
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作者 Jie Cheng Rui-Zhao Li +3 位作者 Cheng Cheng Ya-Lin Zhang Sheng-Li Liu Peng Dong 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第9期671-671,共1页
Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
关键词 corrigendum photonic spin Hall effect multi-functional sensors phase transition sensing performance
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Exploration of multi-functional peptides with bioactive and flavorful properties in Inner Mongolian cheese by peptidomics and bioinformatics 认领 引用
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作者 Yuqian Zheng Zhiyong Cui +8 位作者 Shengnan Wang Chengliang Qi Amin Zhang Xueqian Guo Shilong Zhao Yuan Liu Zhihai Gao Xinya Ma Wenli Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第9期3461-3471,共11页
The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidom... The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC50=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC50=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides. 展开更多
关键词 Inner Mongolian cheese Multi-functional peptides Flavor peptides Antioxidants ACE inhibitory Molecular docking
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A Comprehensive Literature Review of AI-Driven Application Mapping and Scheduling Techniques for Network-on-Chip Systems 认领 引用
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作者 Naveed Ahmad Muhammad Kaleem +5 位作者 Mourad Elloumi Muhammad Azhar Mushtaq Ahlem Fatnassi Mohd Fazil Anas Bilal Abdulbasit A.Darem 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第1期118-155,共38页
Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance ... Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks. 展开更多
关键词 Application mapping mapping techniques network-on-chip system on chip optimisation
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OSAHS患者Fazekas评分及CHIPS评分与非痴呆型血管性认知障碍的关系 认领 引用
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作者 段毅 冯丽 +2 位作者 李娜 韩晓楠 底珊珊 《临床肺科杂志》 2026年第4期565-570,共6页
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者Fazekas评分及CHIPS评分与非痴呆型血管性认知障碍的关系。方法选取2021年3月至2024年3月入本院就诊并经多导睡眠图监测确诊的OSAHS患者,随访1年后,发生非痴呆型血管性认知障碍患者11... 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者Fazekas评分及CHIPS评分与非痴呆型血管性认知障碍的关系。方法选取2021年3月至2024年3月入本院就诊并经多导睡眠图监测确诊的OSAHS患者,随访1年后,发生非痴呆型血管性认知障碍患者115例,为认知障碍组,未发生非痴呆型血管性认知障碍患者125例,为认知正常组。收集患者的一般资料,进行实验室指标检测和睡眠相关指标收集,同时进行Fazekas评分和CHIPS评分。多因素Logistic回归分析影响OSAHS患者发生非痴呆型血管性认知障碍的影响因素,Pearson相关分析Fazekas、CHIPS评分与非痴呆型血管性认知障碍的相关性,采用受试者工作特征(ROC)曲线分析Fazekas和CHIPS评分对OSAHS患者发生非痴呆型血管性认知障碍的诊断效能。结果两组患者的BMI、氧减指数、呼吸暂停低通气指数、最长呼吸暂停时间、睡眠时最低血氧饱和度、Fazekas评分和CHIPS评分对比差异具有统计学意义(P<0.05);重度患者Fazekas及CHIPS评分明显高于中度,中度患者Fazekas及CHIPS评分明显高于轻度(P<0.05);BMI(OR=3.773,95%CI=1.484~9.592)、氧减指数(OR=2.843,95%CI=1.542~5.241)、呼吸暂停低通气指数(OR=2.440,95%CI=1.604~3.711)、最长呼吸暂停时间(OR=3.164,95%CI=1.459~6.863)、Fazekas评分(OR=3.788,95%CI=1.364~10.510)和CHIPS评分(OR=3.575,95%CI=1.360~9.395)是OSAHS患者发生非痴呆型血管性认知障碍的独立危险因素,睡眠时最低血氧饱和度(OR=0.759,95%CI=0.633~0.911)是OSAHS患者发生非痴呆型血管性认知障碍的保护因素(P<0.05);Fazekas、CHIPS评分均与MoCA评分呈正相关性(r s=0.407、0.472,P<0.001);Fazekas评分、CHIPS评分联合评分预测ROC曲线下面积、敏感度和特异度分别优于Fazekas评分、CHIPS评分单独预测(Z=2.436、2.175,P均<0.05)。结论Fazekas及CHIPS评分随着认知障碍程度的增加而升高,是OSAHS患者发生非痴呆型血管性认知障碍的影响因素,与认知障碍显著关联,可以作为早期识别非痴呆型血管性认知障碍的参考依据。 展开更多
关键词 阻塞性睡眠呼吸暂停低通气综合征 非痴呆型血管性认知障碍 Fazekas评分 CHIPS评分 相关性
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Uncertainty-informed large vision model for automated recognition of excavated rock chips in tunnel boring machines 认领 引用
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作者 Xuefeng Ou Wentao Zhou +1 位作者 Tongming Qu Junsheng Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第6期4474-4486,共13页
Real-time identification of rock chip size and shape distributions from muck images plays a critical role in intelligently optimizing cutterhead thrust and torque parameters for tunnel boring machines(TBM).However,com... Real-time identification of rock chip size and shape distributions from muck images plays a critical role in intelligently optimizing cutterhead thrust and torque parameters for tunnel boring machines(TBM).However,complex light environments in field images are difficult to recognize via traditional methods.This paper proposes a U-Net-SAM framework integrating semantic segmentation and the vision foundation model—Segment Anything Model(SAM),combined with dropout-based uncertainty analysis,achieving efficient rock chip segmentation and parameter quantification.First,a U-Net is trained to identify the rock mass centroid as an automatic SAM prompt.Next,an overlap region optimization strategy based on Intersection over Union(IoU)and a noise filtering method is employed to tackle boundary blurring and particle adhesion.Finally,a Dropout layer is added to implement the committee-based uncertainty analysis model and quantify predictive uncertainty.Results show that:(1)U-Net-SAM improves mean F1-score and PA by 9.1%and 7.8%over U-Net;(2)A strong correlation between prediction standard deviation(SD)and error rate validates the proposed uncertainty quantification strategy.This framework provides reliable rock chip perception for intelligent TBM tunneling,with potential applications in other engineering scenarios. 展开更多
关键词 Tunnel boring machine Rock chip recognition Semantic segmentation Vision foundation model Uncertainty analysis U-Net-SAM
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The Present and Future of Aging-on-a-Chip 认领 引用
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作者 Xuan Mei Xingchen Liu +5 位作者 Zaiyi Yang Nigel Foo Peter Wang Ming Shao Dean Ho Yu Shrike Zhang 《Engineering》 SCIE EI CSCD 2026年第7期19-23,共5页
1.Introduction。Aging is a systemic and progressive challenge of significant societal,medical,and scientific urgency.With global populations aging rapidly,age-related diseases,such as neurodegeneration and cardiovascu... 1.Introduction。Aging is a systemic and progressive challenge of significant societal,medical,and scientific urgency.With global populations aging rapidly,age-related diseases,such as neurodegeneration and cardiovascular dysfunction,are accelerating,underscoring the urgent need to understand the mechanisms of aging and develop effective interventions.The trending organ-on-a-chip(OoC)technology offers a powerful solution by recapitulating organ-or tissue-level functions.However,the applications of OoC in aging research remain limited,since most current systems are confined to models that simulate endpoint phenotypes rather than the dynamic evolution of aging itself. 展开更多
关键词 age related diseases organ chip develop effective interventionsthe aging cardiovascular dysfunction understand mechanisms aging neurodegeneration systemic challenge
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An efficient Eggplant1.6K liquid SNP chip for genetic analysis and marker-assisted selection in eggplant 认领 引用
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作者 Duanhua Wang Wenqiu Lin +7 位作者 Qingzhen Wei Qian Li Shuanghua Wu Tianxin Chen Heng Nie Chonglai Bao Jianguo Yang Xi-ou Xiao 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第2期489-492,共4页
Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which h... Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which have been associated with multiple health-promoting properties(Azuma et al.,2008;Gurbuz et al.,2018).Given its significant hybrid vigor,F1 hybrid varieties are widely preferred in commercial cultivation(Mistry et al.,2018).However,traditional breeding practices predominantly rely on phenotypic selection,a process that is not only labor-intensive but also time-consuming. 展开更多
关键词 eggplant phenotypic sel genetic analysis chlorogenic acidwhich bioactive compounds liquid SNP chip Solanum melongena breeding practices
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Engineering Organs-on-Chips and Organoids from the Perspective of Compartmentalization 认领 引用
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作者 Yi Zeng Zhongze Gu +1 位作者 Huafu Chen Xu Deng 《Engineering》 SCIE EI CSCD 2026年第7期13-18,共6页
Advances in stem cell biology and engineering have led to the development of organs-on-chips(OOCs)and organoids,which are in vitro models designed to emulate the structures and functions of human tissues in a more phy... Advances in stem cell biology and engineering have led to the development of organs-on-chips(OOCs)and organoids,which are in vitro models designed to emulate the structures and functions of human tissues in a more physiologically relevant manner than standard two-dimensional(2D)cultures do.After decades of technological progress,these models are now officially recognized tools in drug discovery and safety testing,with their roles evolving from bridging the gap between animal and human studies to validated approaches in reducing animal tests[1].Despite this great progress,only partial physiological structures and simplified functions can be recapitulated with current in vitro tissues,compelling us to seek more improvements in OOC and organoid construction methods. 展开更多
关键词 organoids bridging gap animal human studies drug discovery stem cell biology validated app organs chips vitro models engineering
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Organoids and Organs-on-Chips: Powering the Future of Medicine 认领 引用
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作者 Zhongze Gu Xiaosong Gu 《Engineering》 SCIE EI CSCD 2026年第7期1-2,共2页
For decades,drug development and disease research have been constrained by the limitations of two-dimensional(2D)cell cultures and animal models.These systems,while foundational to early biomedical progress,fail to re... For decades,drug development and disease research have been constrained by the limitations of two-dimensional(2D)cell cultures and animal models.These systems,while foundational to early biomedical progress,fail to replicate the cellular complexity,tissue architecture,and dynamic physiological interactions of human biology,leading to high attrition rates in clinical trials and a critical gap between preclinical findings and real-world patient outcomes.Today,this impasse is being dismantled by two revolutionary technologies:organoids and organs-on-chips(OOCs),which offer unprecedented fidelity to human tissue function and disease pathology.These advanced models bridge the divide between in vitro simplicity and in vivo complexity,providing a window into human biology that was once inaccessible. 展开更多
关键词 animal modelsthese organs chips drug development organoids two dimensional cell cultures animal models clinical trials disease research
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Wafer-Level Self-Assembly and Interface Passivation Patterning Technology for Nanomaterial-Compatible 3D MEMS Sensing Chips 认领 引用 被引量：1
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作者 Zheng Zhang Yanlin Zhang +4 位作者 Yuanyuan Luo Guoliang Lv Jianglin Yin Pengwei Tan Guotao Duan 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第7期106-121,共16页
Wafer-scale fabrication of high-performance microelectro-mechanical systems(MEMS)bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into su... Wafer-scale fabrication of high-performance microelectro-mechanical systems(MEMS)bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into suspended MEMS architectures.Here,a wafer-level manufacturing strategy is presented that redefines the MEMS process flow as“film first,cantilever later.”Through kinetically controlled self-assembly,wet-chemically synthesized Pd/SnO2nanospheres are transferred as dense,uniform monolithic films onto 8-inch wafers.An HfO2interface passivation patterning technology resolves long-standing incompatibility between functional sensing films and silicon substrates,enabling precise patterning and reliable integration on suspended MEMS cantilevers.The resulting Pd/SnO2MEMS H2 chips are fabricated onto an 8-inch wafer,demonstrating high sensitivity and consistency.This approach overcomes long-standing wafer-level manufacturing challenges in the formation and patterning of high-performance nanomaterials film,establishing a fully integrated wafer-level process that fundamentally redefines the manufacturing route for tetramethylammonium hydroxide-resistant nanomaterial-based MEMS sensing chips. 展开更多
关键词 Compatible manufacturing Wafer-level self-assembly Interface passivation patterning technology MEMS Sensing chips
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Toward dioxins and dioxin-like compound detection at the attomolar level via machine learning and nanoplasmonic chips functionalized with aryl hydrocarbon receptors 认领 引用
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作者 LUCA PASQUALE RENZULLO FRANCESCO ARCADIO +5 位作者 DEBORA BENCIVENGA FIORE CAPASSO ROSALBA PITRUZZELLA ADRIANA BORRIELLO LUIGI ZENI NUNZIO CENNAMO 《Photonics Research》 SCIE EI CAS CSCD 2026年第7期3137-3152,共16页
Dioxins and dioxin-like compounds(DLCs)rank among the most dangerous environmental contaminants affecting human health.Reliable and rapid detection tools for dioxins are,therefore,needed.To this end,as a proof-of-conc... Dioxins and dioxin-like compounds(DLCs)rank among the most dangerous environmental contaminants affecting human health.Reliable and rapid detection tools for dioxins are,therefore,needed.To this end,as a proof-of-concept,a sensing strategy based on a machine learning(ML)algorithm combined with a nanoplasmonic biosensor chip is presented for the detection of dioxins and dioxin-like compounds in water solutions.The dataset is generated by exploiting an aryl hydrocarbon receptor(AhR)conjugated layer on a gold nanograting(GNG)plasmonic platform,fabricated on a polymethyl methacrylate substrate via electron-beam lithography and sputtering processes.The sensor system has been tested to detect three different types of dioxins-2,3,7,8-tetrachlorodibenzo-p-dioxin,2,3,7,8-tetrachlorodibenzofuran,and 3,3′,4,4′,5-pentachlorobiphenyl-achieving detection limits of 0.6,1.43,and 6.37 amol/L,respectively.The obtained concentration ranges are below the regulatory values for dioxins in drinking water.Furthermore,to study the AhR-GNG detection capabilities in a complex real-world scenario,the interactions have also been tested in simulated seawater.The proposed sensing approach exploits the distinct binding affinities of dioxins and DLCs for AhR,as monitored by the AhR-GNG biosensor,to train an ML-based tool for classifying various types of dioxins.This strategy,based on an innovative sensing interface(AhR-GNG),named the“MathMaterial sensing interface,”made it possible to identify/classify the three different dioxins tested in this work,both separately and in mixtures.The results showed that the development of ML-based nanoplasmonic biosensor tools for dioxin detection is better suited to realworld scenarios,where multiple types of these contaminants are co-present. 展开更多
关键词 dioxins machine learning nanoplasmonic chips sensing strategy nanoplasmonic biosensor chip detection tools dioxin compounds gold na
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Bioengineering of Heart-Brain Codevelopoid Model via Trans-Germ-Layer Codevelopment Organoid Chip 认领 引用
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作者 Xuemei Huang Wen Zhao +12 位作者 Yuwen Wang Yuxin Wang Tao Chen Lili Zhu Yiran Zhang Jibo Wang Hanwen Cao Yuhang Fan Yunnan Liu Xiaobing Jiang Linlin Bi Changyong Li Pu Chen 《Engineering》 SCIE EI CSCD 2026年第7期118-129,共12页
Interorgan interactions are essential for organogenesis and maturation,with their dysregulation leading to developmental disorders.However,the ability of current physiologically relevant human models to recapitulate i... Interorgan interactions are essential for organogenesis and maturation,with their dysregulation leading to developmental disorders.However,the ability of current physiologically relevant human models to recapitulate interorgan crosstalk during early developmental stages remains limited.Here,we develop a trans-germ-layer codevelopment organoid chip(TGCO-Chip)that enables the coemergence of two interconnected distinct organoids from a common upstream-lineage stem cell aggregate under well-controlled biochemical conditions.Specifically,we established a human pluripotent stem cell-derived heart-brain codevelopoid(HBC)model using a TGCO-Chip,and the codevelopoid recapitulated the developmental features of the heart and brain,including cell lineages,tissue architecture,and functionality.Furthermore,codevelopoids emulate neural projections to cardiac tissues and their regulatory effects during the early developmental stage of organogenesis.Compared with the interconnected heart-heart organoids,the neural compartment significantly increased the average cardiac beating rates and contraction amplitudes.Transcriptomic analysis confirmed that neural compartments in HBCs promoted cardiac differentiation and maturation.Overall,the TGCO-Chip platform provides an innovative tool for bioengineering multiorganoid complexes derived from shared progenitor lineages.Codevelopoids hold immense potential for applications in developmental biology,disease modeling,and regenerative medicine and can provide unprecedented insights into the dynamic interactions between different cell lineages and tissues. 展开更多
关键词 Codevelopoid Multiorganoid Organoid chip Heart-brain axis Interorgan interaction
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Rapid multiplex pathogen detection using 96-channel microfluidic chip with magnetic bead method 认领 引用
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作者 Enjia Zhang Jiaying Cao +6 位作者 Jianxin Cheng Gaozhe Cai Shuyue Jiang Weiwei Xie Chunping Jia Jianlong Zhao Shilun Feng 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期635-642,共8页
The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a mol... The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a molding process,which enables the batch detection of pathogens.It explores the rapid lysis and elution processes of pathogens within the microfluidic chips to ensure that nucleic acid extraction,elution,and amplification are completed entirely within the chip.This chip can extract nucleic acids from samples in just 10 min,achieving an extraction efficiency comparable to that of traditional in-tube methods.An oil phase is pre-loaded into the chip to effectively prevent aerosol contamination.This approach allows for the simultaneous detection of 21 common respiratory pathogens,with a detection limit of 10 copies per reaction.Furthermore,applications involving clinical samples demonstrate significant practicality.Compared to many traditional in-tube pathogen detection methods and molecular biology technologies that utilize microfluidic chips,this detection chip not only enables simultaneous detection of multiple pathogens but also demonstrates high sensitivity. 展开更多
关键词 96-Channel microfuild chip Multiplex pathogen detection Magnetic bead method Respiratory pathogens
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Two-photon polymerization based microfluidic biochip incorporating a herringbone microchannel and deterministic lateral displacement design for efficient capture of circulating tumor cells 认领 引用
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作者 Xinyi LIANG Changwei QIN +10 位作者 Kaiqiang LI An REN Jiarui HU Weikang LV Lunan KE Zhen WANG Mengfei YU Xiuxiu JIANG Huayong YANG Xiaobin XU Liang MA 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第4期334-347,I0008,I0009,I0049,共14页
Circulating tumor cells(CTCs)are cells that become detached from a primary tumor and enter the vascular or lymphatic system.These cells contain nearly the entire genetic information of the primary tumor.Enrichment and... Circulating tumor cells(CTCs)are cells that become detached from a primary tumor and enter the vascular or lymphatic system.These cells contain nearly the entire genetic information of the primary tumor.Enrichment and detection of CTCs play a crucial role in prognostications and risk assessments of tumor metastasis and recurrence,evaluation of efficacy and potential medications for precision tumor therapy,and detection of dynamic biomarkers during tumor treatment.Current methods of CTC capture often face the challenge of balancing capture rate and purity.To address these issues,we propose a microfluidic biochip based on the principle of immunoaffinity,which incorporates a herringbone microchannel and deterministic lateral displacement(DLD)technology for the capture of CTCs.By manipulating the internal structural design of the microfluidic chip,we optimized the flow field within the chip,thereby enhancing the contact frequency between cells and aptamers and ultimately improving the capture rate.The proposed chip demonstrated a capture efficiency of approximately 91.87%for human breast cancer cells(MCF7),with a release rate of 77.5%.The relative activity of the released cells was approximately 94.08%.Notably,the specificity of the aptamers toward tumor cell surface antigens enables high-purity capture.Additionally,the use of DNA enzymes to digest aptamers facilitates the release of high-activity CTCs,offering a method to simultaneously achieve a high capture rate,purity,and activity enrichment. 展开更多
关键词 Circulating tumor cell(CTC) Cell sorting Microfluidic chip Two-photon polymerization Deterministic lateral displacement
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面向国家重大需求的英文科技期刊建设路径探索——以Chip为例 认领 引用 被引量：1
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作者 王骁龙 陈蓉 谈毅 《编辑学报》 CSSCI 北大核心 2026年第2期130-136,共7页
战略性新兴领域英文科技期刊如何在国际期刊竞争中快速建立影响力,是中国高质量科技期刊建设面临的关键问题。本文以入选“中国科技期刊卓越行动计划”高起点新刊的Chip(《芯片》)为研究对象,系统剖析其在战略性新兴领域突围国际期刊竞... 战略性新兴领域英文科技期刊如何在国际期刊竞争中快速建立影响力,是中国高质量科技期刊建设面临的关键问题。本文以入选“中国科技期刊卓越行动计划”高起点新刊的Chip(《芯片》)为研究对象,系统剖析其在战略性新兴领域突围国际期刊竞争、快速建立影响力的实践路径。Chip通过精准对接国家战略需求、建设高水平国际化编委团队、系统化品牌传播、引领性学术活动策划、刊群协同发展等创新举措,实现了跨越式发展,有效承接本土优质成果、打破国际期刊垄断格局。其核心经验在于将服务国家重大需求与学科发展规律有机结合,构建学术声誉与社会影响力双重驱动的发展模式,为中国在关键领域建设世界一流英文科技期刊、实现学术出版突围提供了可供借鉴的范式。 展开更多
关键词 英文科技期刊 国家重大需求 期刊国际化 卓越行动计划 Chip
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Surface-Enhanced Raman Scattering Imaging of Dynamic pH Changes in Lysosomes during Cancer Cell Invasion on a Microfluidic Chip 认领 引用
17
作者 Sijia Liu Mengfei Liu +4 位作者 Mingyu Zhang Xiuyan Ren Mingli Chen Yue Wang Zhangrun Xu 《Chemical & Biomedical Imaging》 CAS CSCD 2026年第2期209-216,共8页
Lysosomes are important organelles involved in intracellular degradation and nutrition-dependent signal transduction.While existing studies have primarily focused on lysosomal pH changes during processes such as lysos... Lysosomes are important organelles involved in intracellular degradation and nutrition-dependent signal transduction.While existing studies have primarily focused on lysosomal pH changes during processes such as lysosomal membrane damage leading to cell death,investigations into lysosomal pH alterations during cell invasion have been largely overlooked.Here,we present a method to analyze lysosomal pH changes during cancer cell invasion using a microfluidic chip-based surface-enhanced Raman scattering(SERS)technique for real-time imaging.Our customdesigned microfluidic chip simulated the cell invasion process,enabling simultaneous,real-time,and in situ SERS monitoring of cells exhibiting varying degrees of invasion and migration.The synthesized pH nanoprobe is based on 4-MPy-modified gold−silver core−shell nanoparticles,boasting good biocompatibility,a high SERS enhancement effect,and subcellular-level targeted monitoring capabilities.Through our SERS microfluidic chip,we observed a slight decrease in lysosomal pH and a slight increase in extracellular pH,with lysosomes predominantly located in the cell periphery during cell invasion.This study contributes to a deeper understanding of the relationship between lysosomes and cancer metastasis. 展开更多
关键词 lysosomes SERS cell invasion microfluidic chip real-time imaging
Study of AWG optoelectronic hybrid integrated chip for FBG interrogation 认领 引用
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作者 Yiyao YANG Pei YUAN +1 位作者 Ran XU Bingxiang LI 《Optoelectronics Letters》 EI 2026年第4期193-197,共5页
To achieve continuous demodulation,high precision,and high resolution in the C-band,this paper designs,simulates and prepares a 30-channel array waveguide grating(AWG)based on a silicon dioxide planar optical circuit ... To achieve continuous demodulation,high precision,and high resolution in the C-band,this paper designs,simulates and prepares a 30-channel array waveguide grating(AWG)based on a silicon dioxide planar optical circuit for fiber Bragg grating(FBG)interrogation and couples the prepared AWG with a photodetector array using hybrid integration technology.The test results indicate that the AWG has a good transmission spectrum,a 3 dB bandwidth of 2.15 nm,an insertion loss of approximately 3.6–4.2 dB,and crosstalk of less than−30 dB.The FBG interrogation system can achieve continuous demodulation in the dynamic range of 1521–1569 nm,and realize continuous demodulation in the C-band with a wavelength resolution of 1 pm and a demodulation accuracy of 5.8 pm.This demodulation method provides an optimization direction for researching FBG interrogation systems based on AWGs. 展开更多
关键词 AWG waveguide grating awg based FBG Interrogation fiber bragg grating fbg interrogation Optoelectronic Hybrid Integrated Chip hybrid integration technologythe insertion loss photodetector array
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Erratum to"Amine-reactive Polymer Platform for Engineering Surface Modification of Next-generation Sequencing Chips" 认领 引用
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作者 Wei Tian Xin-Yuan Wang +4 位作者 Die-Wen Feng Xiang-Qian Li Yue-Kang Jin Hui Li Hao Liu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第1期314-314,I0019,共1页
We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by&quo... We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China".We apologized for the inconvenience caused by this error. 展开更多
关键词 erratum surface modification affiliation next generation sequencing chips reactive polymer platform advanced fiber materialscenter
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Intelligent integration and advancement of multi-organ-on-a-chip 认领 引用
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作者 Chen-Xi Song Lu Huang 《Biomedical Engineering Communications》 CAS 2026年第1期1-3,共3页
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol... Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy. 展开更多
关键词 investigating complex disease mechanisms emulate complex interactions multiple human organs vitro sensor integration intelligent integration predictive accuracy physiological coupling multi organ chip microfluidic systemsthis
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