The philosophy of“treating disease before its onset”is a fundamental concept of traditional Chinese medicine(TCM),permeating its diagnostic and therapeutic framework,and is central to clinical practice.However,curre...The philosophy of“treating disease before its onset”is a fundamental concept of traditional Chinese medicine(TCM),permeating its diagnostic and therapeutic framework,and is central to clinical practice.However,current TCM diagnostic and treatment models for the“predisease to disease”window period face several limitations,including the lack of comprehensive clinical parameters,difficulties in characterizing and integrating heterogeneous multimodal data,and insufficient dynamic precision in interventions and efficacy evaluations.To address these issues,guided by Professor Candong Li’s theory of TCM stateology,this study focuses on integrating objective multimodal data.It proposes a new model for personalized TCM diagnosis and treatment targeting the“pre-disease to disease”window period.This approach first proposes the idea of restructuring the conceptual framework of“symptom”and integrating multi-source heterogeneous data at macroscopic,mesoscopic,and microscopic levels to form a three-dimensional assessment indicator system.By integrating graph neural networks,convolutional neural networks,attention mechanisms,and knowledge graph-guided weight allocation,this approach enables collaborative representation,alignment,and fusion of multi-source data.Subsequently,it plans to construct a multimodal fusion model at both feature and decision levels,in order to establish mappings between indicators and TCM state elements,and to screen key indicators characterizing pathological evolution during the window period.Furthermore,it proposes a technical path for enhancing model interpretability using methods such as SHapley Additive exPlanations(SHAP)and Ablation-CAM++.Finally,with state assessment as the core,it proposes the concept of constructing a dynamic evaluation method for individualized diagnosis and treatment based on time-series data analysis using algorithms such as long short-term memory(LSTM)networks and gated recurrent units(GRUs).Moreover,a causal inference framework and semi-supervised learning strategies are introduced to enable quantitative evaluation of individual intervention effects and to provide interpretable therapeutic feedback,forming a complete technical path from data representation and fusion,weight adjustment,and interpretability analysis,to dynamic diagnosis feedback.This study aims to address deficiencies in the current TCM diagnosis and treatment model during the“pre-disease to disease”window period and to provide an operational framework for the clinical practice of TCM’s“treating disease before its onset”.展开更多
Bone tumors(BTs)-including osteosarcoma,Ewing sarcoma,and chondrosarcoma-are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location,histological subtype,and molecul...Bone tumors(BTs)-including osteosarcoma,Ewing sarcoma,and chondrosarcoma-are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location,histological subtype,and molecular alterations.Recent advances in artificial intelligence(AI),particularly deep learning,have enabled the integration of diverse clinical data modalities to support diagnosis,treatment planning,and prognostication in bone oncology.This review provides a comprehensive synthesis of AI-driven multimodal fusion strategies that incorporate radiological imaging,digital pathology,multi-omics profiling,and electronic health records.We conducted a structured review of peer-reviewed literature published between 2015 and early 2025,focusing on the development,validation,and clinical applicability of AI models for BT diagnosis,subtyping,treatment response prediction,and recurrence monitoring.Although multimodal models have demonstrated advantages over unimodal approaches,especially in handling missing data and improving generalizability,most remain constrained by single-center study designs,small sample sizes,and limited prospective or external validation.Persistent technical and translational challenges include semantic misalignment across modalities,incomplete datasets,limited model interpretability,and regulatory and infrastructural barriers to clinical integration.To address these limitations,we highlight emerging directions such as contrastive representation learning,generative data augmentation,transformer-based fusion architectures,and privacy-preserving federated learning.We also discuss the evolving role of foundation models and workflow-integrated AI agents in enhancing scalability and clinical usability.In summary,multimodal AI represents a promising paradigm for advancing precision care in BTs.Realizing its full clinical potential will require methodologically rigorous,biologically informed,and system-level approaches that bridge algorithmic innovation with real-world healthcare delivery.展开更多
In recent years,microservice architecture has gained increasing popularity.However,due to the complex and dynamically chang⁃ing nature of microservice systems,failure detection has become more challenging.Traditional ...In recent years,microservice architecture has gained increasing popularity.However,due to the complex and dynamically chang⁃ing nature of microservice systems,failure detection has become more challenging.Traditional root cause analysis methods mostly rely on a single modality of data,which is insufficient to cover all failure information.Existing multimodal methods require collecting high-quality la⁃beled samples and often face challenges in classifying unknown failure categories.To address these challenges,this paper proposes a root cause analysis framework based on a masked graph autoencoder(GAE).The main process involves feature extraction,feature dimensionality reduction based on GAE,and online clustering combined with expert input.The method is experimentally evaluated on two public datasets and compared with two baseline methods,demonstrating significant advantages even with 16%labeled samples.展开更多
With the increasing attention to the state and role of people in intelligent manufacturing, there is a strong demand for human-cyber-physical systems (HCPS) that focus on human-robot interaction. The existing intellig...With the increasing attention to the state and role of people in intelligent manufacturing, there is a strong demand for human-cyber-physical systems (HCPS) that focus on human-robot interaction. The existing intelligent manufacturing system cannot satisfy efcient human-robot collaborative work. However, unlike machines equipped with sensors, human characteristic information is difcult to be perceived and digitized instantly. In view of the high complexity and uncertainty of the human body, this paper proposes a framework for building a human digital twin (HDT) model based on multimodal data and expounds on the key technologies. Data acquisition system is built to dynamically acquire and update the body state data and physiological data of the human body and realize the digital expression of multi-source heterogeneous human body information. A bidirectional long short-term memory and convolutional neural network (BiLSTM-CNN) based network is devised to fuse multimodal human data and extract the spatiotemporal features, and the human locomotion mode identifcation is taken as an application case. A series of optimization experiments are carried out to improve the performance of the proposed BiLSTM-CNN-based network model. The proposed model is compared with traditional locomotion mode identifcation models. The experimental results proved the superiority of the HDT framework for human locomotion mode identifcation.展开更多
In this case study, we hypothesized that sympathetic nerve activity would be higher during conversation with PALRO robot, and that conversation would result in an increase in cerebral blood flow near the Broca’s area...In this case study, we hypothesized that sympathetic nerve activity would be higher during conversation with PALRO robot, and that conversation would result in an increase in cerebral blood flow near the Broca’s area. The facial expressions of a human subject were recorded, and cerebral blood flow and heart rate variability were measured during interactions with the humanoid robot. These multimodal data were time-synchronized to quantitatively verify the change from the resting baseline by testing facial expression analysis, cerebral blood flow, and heart rate variability. In conclusion, this subject indicated that sympathetic nervous activity was dominant, suggesting that the subject may have enjoyed and been excited while talking to the robot (normalized High Frequency < normalized Low Frequency: 0.22 ± 0.16 < 0.78 ± 0.16). Cerebral blood flow values were higher during conversation and in the resting state after the experiment than in the resting state before the experiment. Talking increased cerebral blood flow in the frontal region. As the subject was left-handed, it was confirmed that the right side of the brain, where the Broca’s area is located, was particularly activated (Left < right: 0.15 ± 0.21 < 1.25 ± 0.17). In the sections where a “happy” facial emotion was recognized, the examiner-judged “happy” faces and the MTCNN “happy” results were also generally consistent.展开更多
1 Introduction.The development of information technology has promoted the application of multimodal,long-temporal,and multiscale data in healthcare[1].However,the effective utilization of multimodal data still faces c...1 Introduction.The development of information technology has promoted the application of multimodal,long-temporal,and multiscale data in healthcare[1].However,the effective utilization of multimodal data still faces challenges related to feature redundancy within the modality of long temporal data and across multimodal data[2].展开更多
Acupuncture research increasingly involves heterogeneous and multimodal data that are difficult to analyze using conventional methods.This review summarizes data-driven approaches in acupuncture research within a fram...Acupuncture research increasingly involves heterogeneous and multimodal data that are difficult to analyze using conventional methods.This review summarizes data-driven approaches in acupuncture research within a framework encompassing intervention,response,and contextual data.We discuss causal inference,artificial intelligence,text mining,and integrative analysis,along with their applications in efficacy evaluation,outcome prediction,mechanistic investigation,and clinical decision support.These approaches shift the focus of acupuncture research from population-level average effects toward individualized clinical decision-making by enabling the analysis of treatment heterogeneity and underlying mechanisms.However,current research remains limited by inadequate data standardization,insufficient external validation,and limited model interpretability.Despite these challenges,data-driven approaches offer substantial promise for advancing more rigorous and personalized acupuncture research.展开更多
To ensure the safe and stable operation of rotating machinery,intelligent fault diagnosis methods hold significant research value.However,existing diagnostic approaches largely rely on manual feature extraction and ex...To ensure the safe and stable operation of rotating machinery,intelligent fault diagnosis methods hold significant research value.However,existing diagnostic approaches largely rely on manual feature extraction and expert experience,which limits their adaptability under variable operating conditions and strong noise environments,severely affecting the generalization capability of diagnostic models.To address this issue,this study proposes a multimodal fusion fault diagnosis framework based on Mel-spectrograms and automated machine learning(AutoML).The framework first extracts fault-sensitive Mel time–frequency features from acoustic signals and fuses them with statistical features of vibration signals to construct complementary fault representations.On this basis,automated machine learning techniques are introduced to enable end-to-end diagnostic workflow construction and optimal model configuration acquisition.Finally,diagnostic decisions are achieved by automatically integrating the predictions of multiple high-performance base models.Experimental results on a centrifugal pump vibration and acoustic dataset demonstrate that the proposed framework achieves high diagnostic accuracy under noise-free conditions and maintains strong robustness under noisy interference,validating its efficiency,scalability,and practical value for rotating machinery fault diagnosis.展开更多
Dear Editor,Long-term monitoring of different mechanical signals is vital for the health management of modern industrial equipment.Traditional deep learning-based fault diagnosis methods rely much on high-performance ...Dear Editor,Long-term monitoring of different mechanical signals is vital for the health management of modern industrial equipment.Traditional deep learning-based fault diagnosis methods rely much on high-performance computing systems and are difficult to be always-on deployed at the edge.Meanwhile,most of the existing fault diagnosis methods rely on single-sourced sensing data,which only capture limited fault information and cannot well reflect the machine health condition.To address the aforementioned problems,the bio-inspired spiking neural networks(SNNs)offer a promising solution,which simulates the structure and operation of biological neural systems and is more energy and computation-efficient.展开更多
This paper addresses the challenge of efficiently querying multimodal related data in data lakes,a large-scale storage and management system that supports heterogeneous data formats,including structured,semi-structure...This paper addresses the challenge of efficiently querying multimodal related data in data lakes,a large-scale storage and management system that supports heterogeneous data formats,including structured,semi-structured,and unstructured data.Multimodal data queries are crucial because they enable seamless retrieval of related data across modalities,such as tables,images,and text,which has applications in fields like e-commerce,healthcare,and education.However,existing methods primarily focus on single-modality queries,such as joinable or unionable table discovery,and struggle to handle the heterogeneity and lack of metadata in data lakes while balancing accuracy and efficiency.To tackle these challenges,we propose a Multimodal data Query mechanism for Data Lakes(MQDL),which employs a modality-adaptive indexing mechanism raleted and contrastive learning based embeddings to unify representations across modalities.Additionally,we introduce product quantization to optimize candidate verification during queries,reducing computational overhead while maintaining precision.We evaluate MQDL using a table-image dataset across multiple business scenarios,measuring metrics such as precision,recall,and F1-score.Results show that MQDL achieves an accuracy rate of approximately 90%,while demonstrating strong scalability and reduced query response time compared to traditional methods.These findings highlight MQDL's potential to enhance multimodal data retrieval in complex data lake environments.展开更多
Background:Retinal vein occlusion(RvO)is a leading cause of visual impairment on a global scale.Its patho-logical mechanisms involve a complex interplay of vascular obstruction,ischemia,and secondary inflammatory resp...Background:Retinal vein occlusion(RvO)is a leading cause of visual impairment on a global scale.Its patho-logical mechanisms involve a complex interplay of vascular obstruction,ischemia,and secondary inflammatory responses.Recent interdisciplinary advances,underpinned by the integration of multimodal data,have estab-lished a new paradigm for unraveling the pathophysiological mechanisms of RvO,enabling early diagnosis and personalized treatment strategies.Main text:This review critically synthesizes recent progress at the intersection of machine learning,bioinfor-matics,and clinical medicine,focusing on developing predictive models and deep analysis,exploring molecular mechanisms,and identifying markers associated with RvO.By bridging technological innovation with clinical needs,this review underscores the potential of data-driven strategies to advance RvO research and optimize patient care.Conclusions:Machine learning-bioinformatics integration has revolutionised RvO research through predictive modelling and mechanistic insights,particularly via deep learning-enhanced retinal imaging and multi-omics networks.Despite progress,clinical translation requires resolving data standardisation inconsistencies and model generalizability limitations.Establishing multicentre validation frameworks and interpretable AI tools,coupled with patient-focused data platforms through cross-disciplinary collaboration,could enable precision interventions to optimally preserve vision.展开更多
A recent study published in the World Journal of Gastroenterology by Zhu et al demonstrates that machine learning can optimize surgical decision-making for hepatic alveolar echinococcosis(HAE).Through SHapley Additive...A recent study published in the World Journal of Gastroenterology by Zhu et al demonstrates that machine learning can optimize surgical decision-making for hepatic alveolar echinococcosis(HAE).Through SHapley Additive exPlanations analysis,the study indicates that the type of vascular invasion is a key determinant in selecting between hepatectomy and ex vivo liver resection and autotransplantation.The model developed by Zhu et al offers a novel approach for precise preoperative assessment of HAE,holding significant clinical value.However,the model relies on the number of involved vessels to assess vascular invasion and uses a single-line measurement for lesion size,which may underestimate surgical risks and introduce subjective bias.Comprehensive preoperative assessment requires integrating multiple parameters,including the depth and extent of vascular involvement,three-dimensional lesion volume,and postoperative residual functional liver volume,all of which directly influence surgical planning and prognosis.Future efforts should focus on integrating multimodal data and leveraging machine learning to develop more comprehensive and objective risk prediction systems.Building upon this foundation,this paper proposes establishing a“morphology-function”integrated preoperative assessment paradigm to advance the precision of surgical decision-making in HAE.展开更多
Effective survival analysis is essential for identifying optimal preventive treatments within smart healthcare systems and leveraging digital health advancements;however,existing prediction models face limitations,pri...Effective survival analysis is essential for identifying optimal preventive treatments within smart healthcare systems and leveraging digital health advancements;however,existing prediction models face limitations,primarily relying on ensemble classification techniques with suboptimal performance in both target detection and predictive accuracy.To address these gaps,this paper proposes a multimodal framework that integrates enhanced facial feature detection and temporal predictive modeling.For facial feature extraction,this study developed a lightweight faceregion convolutional neural network(FRegNet)specialized in detecting key facial components,such as eyes and lips in clinical patients that incorporates a residual backbone(Rstem)to enhance feature representation and a facial path aggregated feature pyramid network for multi-resolution feature fusion;comparative experiments reveal that FReg-Net outperforms state-of-the-art target detection algorithms,achieving average precision(AP)of 0.922,average recall of 0.933,mean average precision(mAP)of 0.987,and precision of 0.98–significantly surpassing other mask region-based convolutional neural networks(RCNN)variants,such as mask RCNN-ResNeXt with AP of 0.789 and mAP of 0.957.Based on the extracted facial features and clinical physiological indicators,this study proposes an enhanced temporal encoding-decoding(ETED)model that integrates an adaptive attention mechanism and a gated weighting mechanism to improve predictive performance,with comparative results demonstrating that the ETED variant incorporating facial features(ETEncoding-Decoding-Face)outperforms traditional models,achieving an accuracy of 0.916,precision of 0.850,recall of 0.895,F1 of 0.884,and area under the curve(AUC)of 0.947–outperforming gradient boosting with an accuracy of 0.922,but AUC of 0.669,and other classifiers in comprehensive metrics.The results confirm that the multimodal dataset(facial features+physiological indicators)significantly enhances the prediction accuracy of the seven-day survival conditions of patients.Correlation analysis reveals that chronic health evaluation and mean arterial pressure are positively correlated with survival,while temperature,Glasgow Coma Scale,and fibrinogen are negatively correlated.展开更多
Seismic hazards pose a major threat to life safety,social development,and the economy.Traditional seismic vulnerability and risk assessments,such as field survey methods,may not be suitable for densely built-up urban ...Seismic hazards pose a major threat to life safety,social development,and the economy.Traditional seismic vulnerability and risk assessments,such as field survey methods,may not be suitable for densely built-up urban areas due to the limited availability of comprehensive data and potential subjectivity in judgment.To overcome these limitations,an integrated method for seismic vulnerability and risk assessment based on multimodal remote sensing data,support vector machine(SVM)and GIScience methods was proposed and applied to the central urban area of Jinan City,Shandong Province,China.First,an area with representative buildings was selected for field survey research,and an attribute information base established.Then,the SVM method was used to establish the susceptibility proxies,which were applied to the whole study area after accuracy evaluation.Finally,the spatial distribution of seismic vulnerability and risk under different seismic intensity scenarios(from VI to X)was analyzed in GIScience.The results show that the average building vulnerability index in the central urban area of Jinan City is 0.53,indicating that the overall seismic performance of buildings is at a moderate level.Under the seismic intensity scenario of VIII,the buildings in the Starting area and New urban district of Jinan would mostly suffer‘Moderate’damage,while Old urban areas,with more seismic-resistant buildings,would experience only‘Slight’damage.This study aims to offer an efficient and accurate method for assessing seismic vulnerability in mid to large-sized cities characterized by concentrated population densities and rapid urbanization,as well as provide a valuable reference for efforts in urban renewal,seismic mitigation,and land planning,particularly in cities and regions of developing countries.Additionally,it contributes to the realization of Sustainable Development Goal 11,which seeks to make cities and human settlements inclusive,safe,resilient,and sustainable.展开更多
Key components of rail transit systems,such as tracks and vehicle bodies,are prone to developing various types and manifestations of defects during long-term operation.These defects not only accelerate component aging...Key components of rail transit systems,such as tracks and vehicle bodies,are prone to developing various types and manifestations of defects during long-term operation.These defects not only accelerate component aging and failure but also pose serious threats to train operational safety.Among existing intelligent detection methods,they mostly rely solely on visible light images demonstrate limited robustness in complex scenarios.This limitation stems from their high dependence on ambient lighting conditions,rendering them insufficient to meet practical railway inspection requirements.While mainstream multimodal detection methods incorporate the complementary strengths of heterogeneous data sources,they fail to fully leverage the intrinsic associative value of data across different modalities.Furthermore,the occurrence frequency and sample size of various rail transit defects exhibit significant disparities,resulting in severe sample imbalance across detection datasets.This substantially reduces the detection accuracy for rare defect categories.To address these critical technical challenges,this paper proposes a multimodal defect detection method for key components of rail transit systems.The method introduces a multimodal input architecture by integrating Red,Green,Blue(RGB)visual data with depth geometric data.It incorporates a self-learning deep feature fusion module that enables complementary enhancement and deep coupling of heterogeneous modal information.This is achieved through targeted feature extraction and multi-round interactive fusion across different modalities.Additionally,we propose a weighted composite balanced loss function that employs dynamic adaptive weighting factors to adjust the model optimization direction in real time.This method effectively mitigates training bias caused by sample imbalance and improves detection performance for minority defect classes.Finally,experimental results on the track fastener defect RGBD dataset and the vehicle body fastener defect RGBD dataset demonstrate that the proposed method achieves optimal defect detection accuracy and meets real-time inspection requirements.展开更多
Purpose:This study aims to integrate large language models(LLMs)with interpretable machine learning methods to develop a multimodal data-driven framework for predicting corporate financial fraud,addressing the limitat...Purpose:This study aims to integrate large language models(LLMs)with interpretable machine learning methods to develop a multimodal data-driven framework for predicting corporate financial fraud,addressing the limitations of traditional approaches in long-text semantic parsing,model interpretability,and multisource data fusion,thereby providing regulatory agencies with intelligent auditing tools.Design/methodology/approach:Analyzing 5,304 Chinese listed firms’annual reports(2015-2020)from the CSMAD database,this study leverages the Doubao LLMs to generate chunked summaries and 256-dimensional semantic vectors,developing textual semantic features.It integrates 19 financial indicators,11 governance metrics,and linguistic characteristics(tone,readability)with fraud prediction models optimized through a group of Gradient Boosted Decision Tree(GBDT)algorithms.SHAP value analysis in the final model reveals the risk transmission mechanism by quantifying the marginal impacts of financial,governance,and textual features on fraud likelihood.Findings:The study found that LLMs effectively distill lengthy annual reports into semantic summaries,while GBDT algorithms(AUC>0.850)outperform the traditional Logistic Regression model in fraud detection.Multimodal fusion improved performance by 7.4%,with financial,governance,and textual features providing complementary signals.SHAP analysis revealed financial distress,governance conflicts,and narrative patterns(e.g.,tone anchoring,semantic thresholds)as key fraud indicators,highlighting managerial intent in report language.Research limitations:This study identifies three key limitations:1)lack of interpretability for semantic features,2)absence of granular fraud-type differentiation,and 3)unexplored comparative validation with other deep learning methods.Future research will address these gaps to enhance fraud detection precision and model transparency.Practical implications:The developed semantic-enhanced evaluation model provides a quantitative tool for assessing listed companies’information disclosure quality and enables practical implementation through its derivative real-time monitoring system.This advancement significantly strengthens capital market risk early warning capabilities,offering actionable insights for securities regulation.Originality/value:This study presents three key innovations:1)A novel“chunking-summarizationembedding”framework for efficient semantic compression of lengthy annual reports(30,000 words);2)Demonstration of LLMs’superior performance in financial text analysis,outperforming traditional methods by 19.3%;3)A novel“language-psychology-behavior”triad model for analyzing managerial fraud motives.展开更多
With the rapid development of artificial intelligence(AI)technology,multimodal data integration has become an important means to improve the accuracy of diagnosis and treatment in gastroenterology and hepatology.This ...With the rapid development of artificial intelligence(AI)technology,multimodal data integration has become an important means to improve the accuracy of diagnosis and treatment in gastroenterology and hepatology.This article systematically reviews the latest progress of multimodal AI technology in the diagnosis,treatment,and decision-making for gastrointestinal tumors,functional gastrointestinal diseases,and liver diseases,focusing on the innovative applications of endoscopic image AI,pathological section AI,multi-omics data fusion models,and wearable devices combined with natural language processing.Multimodal AI can significantly improve the accuracy of early diagnosis and the efficiency of individualized treatment planning by integrating imaging,pathological data,molecular,and clinical phenotypic data.However,current AI technologies still face challenges such as insufficient data standardization,limited generalization of models,and ethical compliance.This paper proposes solutions,such as the establishment of cross-center data sharing platform,the development of federated learning framework,and the formulation of ethical norms,and looks forward to the application prospect of multimodal large-scale models in the disease management process.This review provides theoretical basis and practical guidance for promoting the clinical translation of AI technology in the field of gastroenterology and hepatology.展开更多
The coronavirus disease 2019 (COVID-19) pandemic has dramatically increased the awareness of emerging infectious diseases. The advancement of multiomics analysis technology has resulted in the development of several d...The coronavirus disease 2019 (COVID-19) pandemic has dramatically increased the awareness of emerging infectious diseases. The advancement of multiomics analysis technology has resulted in the development of several databases containing virus information. Several scientists have integrated existing data on viruses to construct phylogenetic trees and predict virus mutation and transmission in different ways, providing prospective technical support for epidemic prevention and control. This review summarized the databases of known emerging infectious viruses and techniques focusing on virus variant forecasting and early warning. It focuses on the multi-dimensional information integration and database construction of emerging infectious viruses, virus mutation spectrum construction and variant forecast model, analysis of the affinity between mutation antigen and the receptor, propagation model of virus dynamic evolution, and monitoring and early warning for variants. As people have suffered from COVID-19 and repeated flu outbreaks, we focused on the research results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses. This review comprehensively viewed the latest virus research and provided a reference for future virus prevention and control research.展开更多
Hateful meme is a multimodal medium that combines images and texts.The potential hate content of hateful memes has caused serious problems for social media security.The current hateful memes classification task faces ...Hateful meme is a multimodal medium that combines images and texts.The potential hate content of hateful memes has caused serious problems for social media security.The current hateful memes classification task faces significant data scarcity challenges,and direct fine-tuning of large-scale pre-trained models often leads to severe overfitting issues.In addition,it is a challenge to understand the underlying relationship between text and images in the hateful memes.To address these issues,we propose a multimodal hateful memes classification model named LABF,which is based on low-rank adapter layers and bidirectional gated feature fusion.Firstly,low-rank adapter layers are adopted to learn the feature representation of the new dataset.This is achieved by introducing a small number of additional parameters while retaining prior knowledge of the CLIP model,which effectively alleviates the overfitting phenomenon.Secondly,a bidirectional gated feature fusion mechanism is designed to dynamically adjust the interaction weights of text and image features to achieve finer cross-modal fusion.Experimental results show that the method significantly outperforms existing methods on two public datasets,verifying its effectiveness and robustness.展开更多
Alzheimer’s Disease(AD),a prevalent neurodegenerative disorder characterized by memory loss and cognitive decline,poses significant challenges for individuals and society.Multimodal data fusion has emerged as a promi...Alzheimer’s Disease(AD),a prevalent neurodegenerative disorder characterized by memory loss and cognitive decline,poses significant challenges for individuals and society.Multimodal data fusion has emerged as a promising approach for AD diagnosis,with Graph Convolutional Networks(GCNs)effectively capturing irregular brain information.However,traditional GCN methods face limitations in representing and integrating multimodal data,often resulting in feature mismatch.In this study,we propose a novel Kolmogorov-Arnold Graph Attention Network(KAGAN)model to address this issue through semantic-level alignment.KAGAN incorporates a Multimodal Feature Construction method(MuStaF)to extract structural and functional features from T1-and T2-weighted images,and a Multimodal Graph Adjacency Matrix Construction method(MuGAC)to integrate clinical information,modeling intricate relationships across modalities.Experiments conducted on the ADNI dataset demonstrate the superiority of KAGAN in AD/CN/MCI classification,achieving an accuracy of 98.29±1.21%.This highlights KAGAN’s potential for early AD diagnosis by enabling interactive learning and fusion of multimodal features at the semantic level.The source code of our proposed model and the related datasets are available at http://gffzz188fe103f8f1460asofc96co9foc66u9q.ffgz.tsg.suse.edu.cn/sheeprra/KAGAN.展开更多
基金Key Research Project of the National Key Research and Development Program(2023YFC3503003)Special Project for Central Government’s Guidance on Subnational Science and Technology Development by the Fujian Provincial Department of Science and Technology(2024L3014)Domestic First-class Discipline Development Project of Hunan University of Chinese Medicine(XJF[2022]No.57)。
摘要The philosophy of“treating disease before its onset”is a fundamental concept of traditional Chinese medicine(TCM),permeating its diagnostic and therapeutic framework,and is central to clinical practice.However,current TCM diagnostic and treatment models for the“predisease to disease”window period face several limitations,including the lack of comprehensive clinical parameters,difficulties in characterizing and integrating heterogeneous multimodal data,and insufficient dynamic precision in interventions and efficacy evaluations.To address these issues,guided by Professor Candong Li’s theory of TCM stateology,this study focuses on integrating objective multimodal data.It proposes a new model for personalized TCM diagnosis and treatment targeting the“pre-disease to disease”window period.This approach first proposes the idea of restructuring the conceptual framework of“symptom”and integrating multi-source heterogeneous data at macroscopic,mesoscopic,and microscopic levels to form a three-dimensional assessment indicator system.By integrating graph neural networks,convolutional neural networks,attention mechanisms,and knowledge graph-guided weight allocation,this approach enables collaborative representation,alignment,and fusion of multi-source data.Subsequently,it plans to construct a multimodal fusion model at both feature and decision levels,in order to establish mappings between indicators and TCM state elements,and to screen key indicators characterizing pathological evolution during the window period.Furthermore,it proposes a technical path for enhancing model interpretability using methods such as SHapley Additive exPlanations(SHAP)and Ablation-CAM++.Finally,with state assessment as the core,it proposes the concept of constructing a dynamic evaluation method for individualized diagnosis and treatment based on time-series data analysis using algorithms such as long short-term memory(LSTM)networks and gated recurrent units(GRUs).Moreover,a causal inference framework and semi-supervised learning strategies are introduced to enable quantitative evaluation of individual intervention effects and to provide interpretable therapeutic feedback,forming a complete technical path from data representation and fusion,weight adjustment,and interpretability analysis,to dynamic diagnosis feedback.This study aims to address deficiencies in the current TCM diagnosis and treatment model during the“pre-disease to disease”window period and to provide an operational framework for the clinical practice of TCM’s“treating disease before its onset”.
基金supported by the National Natural Science Foundation of China[Grant No.:82172524]the Natural Science Foundation of Hubei Province[Grant No.:2025AFB240].
摘要Bone tumors(BTs)-including osteosarcoma,Ewing sarcoma,and chondrosarcoma-are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location,histological subtype,and molecular alterations.Recent advances in artificial intelligence(AI),particularly deep learning,have enabled the integration of diverse clinical data modalities to support diagnosis,treatment planning,and prognostication in bone oncology.This review provides a comprehensive synthesis of AI-driven multimodal fusion strategies that incorporate radiological imaging,digital pathology,multi-omics profiling,and electronic health records.We conducted a structured review of peer-reviewed literature published between 2015 and early 2025,focusing on the development,validation,and clinical applicability of AI models for BT diagnosis,subtyping,treatment response prediction,and recurrence monitoring.Although multimodal models have demonstrated advantages over unimodal approaches,especially in handling missing data and improving generalizability,most remain constrained by single-center study designs,small sample sizes,and limited prospective or external validation.Persistent technical and translational challenges include semantic misalignment across modalities,incomplete datasets,limited model interpretability,and regulatory and infrastructural barriers to clinical integration.To address these limitations,we highlight emerging directions such as contrastive representation learning,generative data augmentation,transformer-based fusion architectures,and privacy-preserving federated learning.We also discuss the evolving role of foundation models and workflow-integrated AI agents in enhancing scalability and clinical usability.In summary,multimodal AI represents a promising paradigm for advancing precision care in BTs.Realizing its full clinical potential will require methodologically rigorous,biologically informed,and system-level approaches that bridge algorithmic innovation with real-world healthcare delivery.
基金supported by ZTE Industry-University-Institute Coopera⁃tion Funds under Grant No.HC-CN-20221123003.
摘要In recent years,microservice architecture has gained increasing popularity.However,due to the complex and dynamically chang⁃ing nature of microservice systems,failure detection has become more challenging.Traditional root cause analysis methods mostly rely on a single modality of data,which is insufficient to cover all failure information.Existing multimodal methods require collecting high-quality la⁃beled samples and often face challenges in classifying unknown failure categories.To address these challenges,this paper proposes a root cause analysis framework based on a masked graph autoencoder(GAE).The main process involves feature extraction,feature dimensionality reduction based on GAE,and online clustering combined with expert input.The method is experimentally evaluated on two public datasets and compared with two baseline methods,demonstrating significant advantages even with 16%labeled samples.
基金Supported by National Natural Science Foundation of China(Grant Nos.52205288,52130501,52075479)Zhejiang Provincial Key Research&Development Program(Grant No.2021C01110).
摘要With the increasing attention to the state and role of people in intelligent manufacturing, there is a strong demand for human-cyber-physical systems (HCPS) that focus on human-robot interaction. The existing intelligent manufacturing system cannot satisfy efcient human-robot collaborative work. However, unlike machines equipped with sensors, human characteristic information is difcult to be perceived and digitized instantly. In view of the high complexity and uncertainty of the human body, this paper proposes a framework for building a human digital twin (HDT) model based on multimodal data and expounds on the key technologies. Data acquisition system is built to dynamically acquire and update the body state data and physiological data of the human body and realize the digital expression of multi-source heterogeneous human body information. A bidirectional long short-term memory and convolutional neural network (BiLSTM-CNN) based network is devised to fuse multimodal human data and extract the spatiotemporal features, and the human locomotion mode identifcation is taken as an application case. A series of optimization experiments are carried out to improve the performance of the proposed BiLSTM-CNN-based network model. The proposed model is compared with traditional locomotion mode identifcation models. The experimental results proved the superiority of the HDT framework for human locomotion mode identifcation.
摘要In this case study, we hypothesized that sympathetic nerve activity would be higher during conversation with PALRO robot, and that conversation would result in an increase in cerebral blood flow near the Broca’s area. The facial expressions of a human subject were recorded, and cerebral blood flow and heart rate variability were measured during interactions with the humanoid robot. These multimodal data were time-synchronized to quantitatively verify the change from the resting baseline by testing facial expression analysis, cerebral blood flow, and heart rate variability. In conclusion, this subject indicated that sympathetic nervous activity was dominant, suggesting that the subject may have enjoyed and been excited while talking to the robot (normalized High Frequency < normalized Low Frequency: 0.22 ± 0.16 < 0.78 ± 0.16). Cerebral blood flow values were higher during conversation and in the resting state after the experiment than in the resting state before the experiment. Talking increased cerebral blood flow in the frontal region. As the subject was left-handed, it was confirmed that the right side of the brain, where the Broca’s area is located, was particularly activated (Left < right: 0.15 ± 0.21 < 1.25 ± 0.17). In the sections where a “happy” facial emotion was recognized, the examiner-judged “happy” faces and the MTCNN “happy” results were also generally consistent.
基金supported by the National Key Research and Development Program of China(2024YFF1207002)the National Natural Science Foundation of China(Grant Nos.82325027,82030047,82441011)the Research Funds of Center for Big Data and Population Health of IHM(JKS2022002,JKS2022001).
摘要1 Introduction.The development of information technology has promoted the application of multimodal,long-temporal,and multiscale data in healthcare[1].However,the effective utilization of multimodal data still faces challenges related to feature redundancy within the modality of long temporal data and across multimodal data[2].
基金supported by the Zhongshan TCM Heritage and Innovation Research Program(No.2024B3006)the Peak-Shaping Project under Guangzhou University of Chinese Medicine's Action Plan for Double First-Class and High-Level Disciplinary Development(No.GZY2025ZJ18)+1 种基金the Sanming Project of Medicine in Shenzhen(No.SZZYSM202311015)the Shenzhen Medical Research Fund(No.C2501027).
摘要Acupuncture research increasingly involves heterogeneous and multimodal data that are difficult to analyze using conventional methods.This review summarizes data-driven approaches in acupuncture research within a framework encompassing intervention,response,and contextual data.We discuss causal inference,artificial intelligence,text mining,and integrative analysis,along with their applications in efficacy evaluation,outcome prediction,mechanistic investigation,and clinical decision support.These approaches shift the focus of acupuncture research from population-level average effects toward individualized clinical decision-making by enabling the analysis of treatment heterogeneity and underlying mechanisms.However,current research remains limited by inadequate data standardization,insufficient external validation,and limited model interpretability.Despite these challenges,data-driven approaches offer substantial promise for advancing more rigorous and personalized acupuncture research.
基金supported in part by the National Natural Science Foundation of China under Grants 52475102 and 52205101in part by the Guangdong Basic and Applied Basic Research Foundation under Grant 2023A1515240021+1 种基金in part by the Young Talent Support Project of Guangzhou Association for Science and Technology(QT-2024-28)in part by the Youth Development Initiative of Guangdong Association for Science and Technology(SKXRC2025254).
摘要To ensure the safe and stable operation of rotating machinery,intelligent fault diagnosis methods hold significant research value.However,existing diagnostic approaches largely rely on manual feature extraction and expert experience,which limits their adaptability under variable operating conditions and strong noise environments,severely affecting the generalization capability of diagnostic models.To address this issue,this study proposes a multimodal fusion fault diagnosis framework based on Mel-spectrograms and automated machine learning(AutoML).The framework first extracts fault-sensitive Mel time–frequency features from acoustic signals and fuses them with statistical features of vibration signals to construct complementary fault representations.On this basis,automated machine learning techniques are introduced to enable end-to-end diagnostic workflow construction and optimal model configuration acquisition.Finally,diagnostic decisions are achieved by automatically integrating the predictions of multiple high-performance base models.Experimental results on a centrifugal pump vibration and acoustic dataset demonstrate that the proposed framework achieves high diagnostic accuracy under noise-free conditions and maintains strong robustness under noisy interference,validating its efficiency,scalability,and practical value for rotating machinery fault diagnosis.
摘要Dear Editor,Long-term monitoring of different mechanical signals is vital for the health management of modern industrial equipment.Traditional deep learning-based fault diagnosis methods rely much on high-performance computing systems and are difficult to be always-on deployed at the edge.Meanwhile,most of the existing fault diagnosis methods rely on single-sourced sensing data,which only capture limited fault information and cannot well reflect the machine health condition.To address the aforementioned problems,the bio-inspired spiking neural networks(SNNs)offer a promising solution,which simulates the structure and operation of biological neural systems and is more energy and computation-efficient.
摘要This paper addresses the challenge of efficiently querying multimodal related data in data lakes,a large-scale storage and management system that supports heterogeneous data formats,including structured,semi-structured,and unstructured data.Multimodal data queries are crucial because they enable seamless retrieval of related data across modalities,such as tables,images,and text,which has applications in fields like e-commerce,healthcare,and education.However,existing methods primarily focus on single-modality queries,such as joinable or unionable table discovery,and struggle to handle the heterogeneity and lack of metadata in data lakes while balancing accuracy and efficiency.To tackle these challenges,we propose a Multimodal data Query mechanism for Data Lakes(MQDL),which employs a modality-adaptive indexing mechanism raleted and contrastive learning based embeddings to unify representations across modalities.Additionally,we introduce product quantization to optimize candidate verification during queries,reducing computational overhead while maintaining precision.We evaluate MQDL using a table-image dataset across multiple business scenarios,measuring metrics such as precision,recall,and F1-score.Results show that MQDL achieves an accuracy rate of approximately 90%,while demonstrating strong scalability and reduced query response time compared to traditional methods.These findings highlight MQDL's potential to enhance multimodal data retrieval in complex data lake environments.
基金supported by the National Natural Science Foundation of China(82271094 to J.Z.).
摘要Background:Retinal vein occlusion(RvO)is a leading cause of visual impairment on a global scale.Its patho-logical mechanisms involve a complex interplay of vascular obstruction,ischemia,and secondary inflammatory responses.Recent interdisciplinary advances,underpinned by the integration of multimodal data,have estab-lished a new paradigm for unraveling the pathophysiological mechanisms of RvO,enabling early diagnosis and personalized treatment strategies.Main text:This review critically synthesizes recent progress at the intersection of machine learning,bioinfor-matics,and clinical medicine,focusing on developing predictive models and deep analysis,exploring molecular mechanisms,and identifying markers associated with RvO.By bridging technological innovation with clinical needs,this review underscores the potential of data-driven strategies to advance RvO research and optimize patient care.Conclusions:Machine learning-bioinformatics integration has revolutionised RvO research through predictive modelling and mechanistic insights,particularly via deep learning-enhanced retinal imaging and multi-omics networks.Despite progress,clinical translation requires resolving data standardisation inconsistencies and model generalizability limitations.Establishing multicentre validation frameworks and interpretable AI tools,coupled with patient-focused data platforms through cross-disciplinary collaboration,could enable precision interventions to optimally preserve vision.
摘要A recent study published in the World Journal of Gastroenterology by Zhu et al demonstrates that machine learning can optimize surgical decision-making for hepatic alveolar echinococcosis(HAE).Through SHapley Additive exPlanations analysis,the study indicates that the type of vascular invasion is a key determinant in selecting between hepatectomy and ex vivo liver resection and autotransplantation.The model developed by Zhu et al offers a novel approach for precise preoperative assessment of HAE,holding significant clinical value.However,the model relies on the number of involved vessels to assess vascular invasion and uses a single-line measurement for lesion size,which may underestimate surgical risks and introduce subjective bias.Comprehensive preoperative assessment requires integrating multiple parameters,including the depth and extent of vascular involvement,three-dimensional lesion volume,and postoperative residual functional liver volume,all of which directly influence surgical planning and prognosis.Future efforts should focus on integrating multimodal data and leveraging machine learning to develop more comprehensive and objective risk prediction systems.Building upon this foundation,this paper proposes establishing a“morphology-function”integrated preoperative assessment paradigm to advance the precision of surgical decision-making in HAE.
基金supported by the National Key Research and Development Program,No.2022YFB4703500Shenzhen High-tech Zone Development Special Plan Innovation Platform Construction Project+3 种基金the Proof of Concept Center for High Precision and High Resolution 4D Imagingthe National Key Research and Development Program,No.2022YFB4703500Beijing Natural Science Foundation,No.L243005National Natural Science Foundation of China,No.82372218.
摘要Effective survival analysis is essential for identifying optimal preventive treatments within smart healthcare systems and leveraging digital health advancements;however,existing prediction models face limitations,primarily relying on ensemble classification techniques with suboptimal performance in both target detection and predictive accuracy.To address these gaps,this paper proposes a multimodal framework that integrates enhanced facial feature detection and temporal predictive modeling.For facial feature extraction,this study developed a lightweight faceregion convolutional neural network(FRegNet)specialized in detecting key facial components,such as eyes and lips in clinical patients that incorporates a residual backbone(Rstem)to enhance feature representation and a facial path aggregated feature pyramid network for multi-resolution feature fusion;comparative experiments reveal that FReg-Net outperforms state-of-the-art target detection algorithms,achieving average precision(AP)of 0.922,average recall of 0.933,mean average precision(mAP)of 0.987,and precision of 0.98–significantly surpassing other mask region-based convolutional neural networks(RCNN)variants,such as mask RCNN-ResNeXt with AP of 0.789 and mAP of 0.957.Based on the extracted facial features and clinical physiological indicators,this study proposes an enhanced temporal encoding-decoding(ETED)model that integrates an adaptive attention mechanism and a gated weighting mechanism to improve predictive performance,with comparative results demonstrating that the ETED variant incorporating facial features(ETEncoding-Decoding-Face)outperforms traditional models,achieving an accuracy of 0.916,precision of 0.850,recall of 0.895,F1 of 0.884,and area under the curve(AUC)of 0.947–outperforming gradient boosting with an accuracy of 0.922,but AUC of 0.669,and other classifiers in comprehensive metrics.The results confirm that the multimodal dataset(facial features+physiological indicators)significantly enhances the prediction accuracy of the seven-day survival conditions of patients.Correlation analysis reveals that chronic health evaluation and mean arterial pressure are positively correlated with survival,while temperature,Glasgow Coma Scale,and fibrinogen are negatively correlated.
基金supported in part by the National Natural Science Foundation of China(Grant No.42201077)the Natural Science Foundation of Shandong Province(No.ZR2021QD074)+2 种基金the China Postdoctoral Science Foundation(No.2023M732105)the Lhasa National Geophysical Observation and Research Station(No.NORSLS22-05)the Youth Innovation Team Project of Higher School in Shandong Province,China(No.2024KJH087).
摘要Seismic hazards pose a major threat to life safety,social development,and the economy.Traditional seismic vulnerability and risk assessments,such as field survey methods,may not be suitable for densely built-up urban areas due to the limited availability of comprehensive data and potential subjectivity in judgment.To overcome these limitations,an integrated method for seismic vulnerability and risk assessment based on multimodal remote sensing data,support vector machine(SVM)and GIScience methods was proposed and applied to the central urban area of Jinan City,Shandong Province,China.First,an area with representative buildings was selected for field survey research,and an attribute information base established.Then,the SVM method was used to establish the susceptibility proxies,which were applied to the whole study area after accuracy evaluation.Finally,the spatial distribution of seismic vulnerability and risk under different seismic intensity scenarios(from VI to X)was analyzed in GIScience.The results show that the average building vulnerability index in the central urban area of Jinan City is 0.53,indicating that the overall seismic performance of buildings is at a moderate level.Under the seismic intensity scenario of VIII,the buildings in the Starting area and New urban district of Jinan would mostly suffer‘Moderate’damage,while Old urban areas,with more seismic-resistant buildings,would experience only‘Slight’damage.This study aims to offer an efficient and accurate method for assessing seismic vulnerability in mid to large-sized cities characterized by concentrated population densities and rapid urbanization,as well as provide a valuable reference for efforts in urban renewal,seismic mitigation,and land planning,particularly in cities and regions of developing countries.Additionally,it contributes to the realization of Sustainable Development Goal 11,which seeks to make cities and human settlements inclusive,safe,resilient,and sustainable.
基金funded by Beijing Natural Science Foundation,grant number L241078the Postdoctoral Fellowship Program of CPSF,grant number GZC20251118Beijing Subway Operation Co.,Ltd.
摘要Key components of rail transit systems,such as tracks and vehicle bodies,are prone to developing various types and manifestations of defects during long-term operation.These defects not only accelerate component aging and failure but also pose serious threats to train operational safety.Among existing intelligent detection methods,they mostly rely solely on visible light images demonstrate limited robustness in complex scenarios.This limitation stems from their high dependence on ambient lighting conditions,rendering them insufficient to meet practical railway inspection requirements.While mainstream multimodal detection methods incorporate the complementary strengths of heterogeneous data sources,they fail to fully leverage the intrinsic associative value of data across different modalities.Furthermore,the occurrence frequency and sample size of various rail transit defects exhibit significant disparities,resulting in severe sample imbalance across detection datasets.This substantially reduces the detection accuracy for rare defect categories.To address these critical technical challenges,this paper proposes a multimodal defect detection method for key components of rail transit systems.The method introduces a multimodal input architecture by integrating Red,Green,Blue(RGB)visual data with depth geometric data.It incorporates a self-learning deep feature fusion module that enables complementary enhancement and deep coupling of heterogeneous modal information.This is achieved through targeted feature extraction and multi-round interactive fusion across different modalities.Additionally,we propose a weighted composite balanced loss function that employs dynamic adaptive weighting factors to adjust the model optimization direction in real time.This method effectively mitigates training bias caused by sample imbalance and improves detection performance for minority defect classes.Finally,experimental results on the track fastener defect RGBD dataset and the vehicle body fastener defect RGBD dataset demonstrate that the proposed method achieves optimal defect detection accuracy and meets real-time inspection requirements.
基金supported by the 2021 Guangdong Province(China)Science and Technology Plan Project“Research and Application of Key Technologies for Multi-level Knowledge Retrieval Based on Big Data Intelligence”(Project No.2021B0101420004)the 2022 commissioned project“Cross-border E-commerce Taxation and Related Research”from the State Taxation Administration Guangdong Provincial Taxation Bureau,China.
摘要Purpose:This study aims to integrate large language models(LLMs)with interpretable machine learning methods to develop a multimodal data-driven framework for predicting corporate financial fraud,addressing the limitations of traditional approaches in long-text semantic parsing,model interpretability,and multisource data fusion,thereby providing regulatory agencies with intelligent auditing tools.Design/methodology/approach:Analyzing 5,304 Chinese listed firms’annual reports(2015-2020)from the CSMAD database,this study leverages the Doubao LLMs to generate chunked summaries and 256-dimensional semantic vectors,developing textual semantic features.It integrates 19 financial indicators,11 governance metrics,and linguistic characteristics(tone,readability)with fraud prediction models optimized through a group of Gradient Boosted Decision Tree(GBDT)algorithms.SHAP value analysis in the final model reveals the risk transmission mechanism by quantifying the marginal impacts of financial,governance,and textual features on fraud likelihood.Findings:The study found that LLMs effectively distill lengthy annual reports into semantic summaries,while GBDT algorithms(AUC>0.850)outperform the traditional Logistic Regression model in fraud detection.Multimodal fusion improved performance by 7.4%,with financial,governance,and textual features providing complementary signals.SHAP analysis revealed financial distress,governance conflicts,and narrative patterns(e.g.,tone anchoring,semantic thresholds)as key fraud indicators,highlighting managerial intent in report language.Research limitations:This study identifies three key limitations:1)lack of interpretability for semantic features,2)absence of granular fraud-type differentiation,and 3)unexplored comparative validation with other deep learning methods.Future research will address these gaps to enhance fraud detection precision and model transparency.Practical implications:The developed semantic-enhanced evaluation model provides a quantitative tool for assessing listed companies’information disclosure quality and enables practical implementation through its derivative real-time monitoring system.This advancement significantly strengthens capital market risk early warning capabilities,offering actionable insights for securities regulation.Originality/value:This study presents three key innovations:1)A novel“chunking-summarizationembedding”framework for efficient semantic compression of lengthy annual reports(30,000 words);2)Demonstration of LLMs’superior performance in financial text analysis,outperforming traditional methods by 19.3%;3)A novel“language-psychology-behavior”triad model for analyzing managerial fraud motives.
摘要With the rapid development of artificial intelligence(AI)technology,multimodal data integration has become an important means to improve the accuracy of diagnosis and treatment in gastroenterology and hepatology.This article systematically reviews the latest progress of multimodal AI technology in the diagnosis,treatment,and decision-making for gastrointestinal tumors,functional gastrointestinal diseases,and liver diseases,focusing on the innovative applications of endoscopic image AI,pathological section AI,multi-omics data fusion models,and wearable devices combined with natural language processing.Multimodal AI can significantly improve the accuracy of early diagnosis and the efficiency of individualized treatment planning by integrating imaging,pathological data,molecular,and clinical phenotypic data.However,current AI technologies still face challenges such as insufficient data standardization,limited generalization of models,and ethical compliance.This paper proposes solutions,such as the establishment of cross-center data sharing platform,the development of federated learning framework,and the formulation of ethical norms,and looks forward to the application prospect of multimodal large-scale models in the disease management process.This review provides theoretical basis and practical guidance for promoting the clinical translation of AI technology in the field of gastroenterology and hepatology.
基金supported by the National Key R&D Program of China(2022YFF1203202,2018YFC2000205)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38050200,XDA26040304)the Self-supporting Program of Guangzhou Laboratory(SRPG22-007).
摘要The coronavirus disease 2019 (COVID-19) pandemic has dramatically increased the awareness of emerging infectious diseases. The advancement of multiomics analysis technology has resulted in the development of several databases containing virus information. Several scientists have integrated existing data on viruses to construct phylogenetic trees and predict virus mutation and transmission in different ways, providing prospective technical support for epidemic prevention and control. This review summarized the databases of known emerging infectious viruses and techniques focusing on virus variant forecasting and early warning. It focuses on the multi-dimensional information integration and database construction of emerging infectious viruses, virus mutation spectrum construction and variant forecast model, analysis of the affinity between mutation antigen and the receptor, propagation model of virus dynamic evolution, and monitoring and early warning for variants. As people have suffered from COVID-19 and repeated flu outbreaks, we focused on the research results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses. This review comprehensively viewed the latest virus research and provided a reference for future virus prevention and control research.
基金supported by the Funding for Research on the Evolution of Cyberbullying Incidents and Intervention Strategies(24BSH033)Discipline Innovation and Talent Introduction Bases in Higher Education Institutions(B20087).
摘要Hateful meme is a multimodal medium that combines images and texts.The potential hate content of hateful memes has caused serious problems for social media security.The current hateful memes classification task faces significant data scarcity challenges,and direct fine-tuning of large-scale pre-trained models often leads to severe overfitting issues.In addition,it is a challenge to understand the underlying relationship between text and images in the hateful memes.To address these issues,we propose a multimodal hateful memes classification model named LABF,which is based on low-rank adapter layers and bidirectional gated feature fusion.Firstly,low-rank adapter layers are adopted to learn the feature representation of the new dataset.This is achieved by introducing a small number of additional parameters while retaining prior knowledge of the CLIP model,which effectively alleviates the overfitting phenomenon.Secondly,a bidirectional gated feature fusion mechanism is designed to dynamically adjust the interaction weights of text and image features to achieve finer cross-modal fusion.Experimental results show that the method significantly outperforms existing methods on two public datasets,verifying its effectiveness and robustness.
基金supported by the National Natural Science Foundation of China(62276092,62303167)the Postdoctoral Fellowship Program(Grade C)of China Postdoctoral Science Foundation(GZC20230707)+4 种基金the Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(2025HYTP061)the Key Science and Technology Program of Henan Province,China(242102211051,212102310084)Key Scientific Research Projects of Colleges and Universities in Henan Province,China(25A520009)the China Postdoctoral Science Foundation(2024M760808)the Henan Province medical science and technology research plan joint construction project(LHGJ2024069).
摘要Alzheimer’s Disease(AD),a prevalent neurodegenerative disorder characterized by memory loss and cognitive decline,poses significant challenges for individuals and society.Multimodal data fusion has emerged as a promising approach for AD diagnosis,with Graph Convolutional Networks(GCNs)effectively capturing irregular brain information.However,traditional GCN methods face limitations in representing and integrating multimodal data,often resulting in feature mismatch.In this study,we propose a novel Kolmogorov-Arnold Graph Attention Network(KAGAN)model to address this issue through semantic-level alignment.KAGAN incorporates a Multimodal Feature Construction method(MuStaF)to extract structural and functional features from T1-and T2-weighted images,and a Multimodal Graph Adjacency Matrix Construction method(MuGAC)to integrate clinical information,modeling intricate relationships across modalities.Experiments conducted on the ADNI dataset demonstrate the superiority of KAGAN in AD/CN/MCI classification,achieving an accuracy of 98.29±1.21%.This highlights KAGAN’s potential for early AD diagnosis by enabling interactive learning and fusion of multimodal features at the semantic level.The source code of our proposed model and the related datasets are available at http://gffzz188fe103f8f1460asofc96co9foc66u9q.ffgz.tsg.suse.edu.cn/sheeprra/KAGAN.