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Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines 认领 引用 被引量：4
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作者 Barry M Berger Bernard Levin Robert J Hilsden 《World Journal of Gastrointestinal Oncology》 SCIE 2016年第5期450-458,共9页
Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).T... Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. 展开更多
关键词 Colorectal cancer screening Multitarget stool DNA Stool DNA The United States Preventive Services Task Force Cancer Intervention Surveillance Modeling Network Fecal immunological technique Modeling Interval
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A new binding mode for ecdysteroid analog tebufenozide as a multitargeted IGR with chitinase 认领 引用 被引量：1
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作者 Jia-lin Cui Yan-jiao Feng +4 位作者 Xiu-zhen Li Hong-Yan Wang Qi Hea Li Zhang Qing Yang 《Advanced Agrochem》 CAS 2024年第3期229-236,共8页
Tebufenozide,an efficient insect growth regulator(IGR)against lepidopteran pests,presents a novel mode of action with minimal non-target impact.By competing with ecdysteroids for ecdysone receptor(EcR)binding,it regul... Tebufenozide,an efficient insect growth regulator(IGR)against lepidopteran pests,presents a novel mode of action with minimal non-target impact.By competing with ecdysteroids for ecdysone receptor(EcR)binding,it regulates insect growth precisely.This study explores tebufenozide's potential as a multitarget IGR,targeting both EcR and Ostrinia furnacalis chitinase I(OfChtI).The inhibitory activity against OfChtI is comparable to that of substrates(GlcNAc)5,with an IC50 of 45.77μM.Our computational findings indicate that tebufenozide binds at the subsite1 to t1 of OfChtI through various interactions.Notably,tebufenozide establishes a pi-pi interaction with the flipped sidechain of Trp107,enabling tebufenozide to deeply penetrate into the S1 pocket,thereby obstructing substrate binding to OfChtI.These insights highlight the potency of multitarget strategies,laying the groundwork for innovative IGR designs that offer comprehensive pest management solutions. 展开更多
关键词 Tebufenozide Ecdysone receptor Chitinase Multitarget insect growth regulator
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Multi-Deme Parallel FGAs-Based Algorithm for Multitarget Tracking 认领 引用 被引量：1
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作者 刘虎 朱力立 张焕春 《Journal of Electronic Science and Technology of China》 2006年第1期12-17,共6页
For data association in multisensor and multitarget tracking, a novel parallel algorithm is developed to improve the efficiency and real-time performance of FGAs-based algorithm. One Cluster of Workstation （COW） wit... For data association in multisensor and multitarget tracking, a novel parallel algorithm is developed to improve the efficiency and real-time performance of FGAs-based algorithm. One Cluster of Workstation （COW） with Message Passing Interface （MPI） is built. The proposed Multi-Deme Parallel FGA （MDPFGA） is run on the platform. A serial of special MDPFGAs are used to determine the static and the dynamic solutions of generalized m-best S-D assignment problem respectively, as well as target states estimation in track management. Such an assignment-based parallel algorithm is demonstrated on simulated passive sensor track formation and maintenance problem. While illustrating the feasibility of the proposed algorithm in multisensor multitarget tracking, simulation results indicate that the MDPFGAs-based algorithm has greater efficiency and speed than the FGAs-based algorithm. 展开更多
关键词 multitarget tracking multi-deme Fuzzy Genetic Algorithm （FGA） parallelization Message Passing Interface （MPI）
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Multitarget stool DNA tests increases colorectal cancer screening among previously noncompliant Medicare patients 认领 引用 被引量：4
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作者 Mark Prince Lynn Lester +1 位作者 Rupal Chiniwala Barry Berger 《World Journal of Gastroenterology》 SCIE CAS 2017年第3期464-471,共8页
AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare patients.METHODS This cross sectional primary care office... AIM To determine the uptake of noninvasive multitarget stool DNA (mt-s DNA) in a cohort of colorectal cancer(CRC) screening non-compliant average-risk Medicare patients.METHODS This cross sectional primary care office-based study examined mt-s DNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015. Investigators performed a Health Insurance Portability and Accountability Act compliant retrospective review of electronic health records to identify mt-s DNA use in patients who were either > 10 years since last colonoscopy and/or > 1 year since last fecal occult blood test. Test positive patients were advised to get diagnostic colonoscopy and thereafter patients were characterized by the most clinically significant lesion documented on histopathology of biopsies or excisional tissue. Descriptive statistics were employed. Key outcome measures included mt-s DNA compliance and diagnostic colonoscopy compliance on positive cases.RESULTS Over 12 mo, 77 providers ordered 393 mt-sD NA studies with 347 completed (88.3% compliance). Patient mean age was 69.8 (50-85) and patients were 64% female. Mt-sD NA was negative in 85.3%(296/347) and positive in 14.7%(51/347). Follow-up colonoscopy was performed in 49 positive patients (96.1% colonoscopy compliance) with two patients lost to follow up. Index findings included: colon cancer(4/49, 8.2%), advanced adenomas (21/49, 42.9%), non-advanced adenomas(15/49, 30.6%), and negative results (9/49, 18.4%). The positive predictive value for advanced colorectal lesions was 51.0% and for any colorectal neoplasia was 81.6%. The mean age of patients with colorectal cancer was 70.3 and all CRC's were localized Stage Ⅰ(2) and Stage Ⅱ (2), three were located in the proximal colon and one was located in the distal colon.CONCLUSION Mt-s DNA provided medical benefit to screening noncompliant Medicare population. High compliance with mt-s DNA and subsequent follow-up diagnostic colonoscopy identified patients with clinically critical advanced colorectal neoplasia. 展开更多
关键词 Multitarget stool DNA Advanced adenoma Screening compliance Colonoscopy Colorectal cancer screening Preventive
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A measurement-driven adaptive probability hypothesis density filter for multitarget tracking 认领 引用 被引量：9
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作者 Si Weijian Wang Liwei Qu Zhiyu 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2015年第6期1689-1698,共10页
This paper studies the dynamic estimation problem for multitarget tracking. A novel gat- ing strategy that is based on the measurement likelihood of the target state space is proposed to improve the overall effectiven... This paper studies the dynamic estimation problem for multitarget tracking. A novel gat- ing strategy that is based on the measurement likelihood of the target state space is proposed to improve the overall effectiveness of the probability hypothesis density （PHD） filter. Firstly, a measurement-driven mechanism based on this gating technique is designed to classify the measure- ments. In this mechanism, only the measurements for the existing targets are considered in the update step of the existing targets while the measurements of newborn targets are used for exploring newborn targets. Secondly, the gating strategy enables the development of a heuristic state estima- tion algorithm when sequential Monte Carlo （SMC） implementation of the PHD filter is investi- gated, where the measurements are used to drive the particle clustering within the space gate. The resulting PHD filter can achieve a more robust and accurate estimation of the existing targets by reducing the interference from clutter. Moreover, the target birth intensity can be adaptive to detect newborn targets, which is in accordance with the birth measurements. Simulation results demonstrate the computational efficiency and tracking performance of the proposed algorithm. 展开更多
关键词 Adaptive Measurement-driven Multitarget trackin Probability hypothesis density Sequential Monte Carlo
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Exploiting natural products to discover multitarget inhibitors of insect chitinolytic enzymes 认领 引用 被引量：1
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作者 Yi Ding Qiong Lu +1 位作者 Tian Liu Qing Yang 《Advanced Agrochem》 CAS 2023年第4期306-312,共7页
Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk of resistance.Insect chitinolytic enzymes,including GH18 chitinases and GH20β-N-acetyl-D-hexosaminidase,are attr... Multitarget insecticides are more likely to achieve comprehensive regulation of insects with a low risk of resistance.Insect chitinolytic enzymes,including GH18 chitinases and GH20β-N-acetyl-D-hexosaminidase,are attractive targets for multitarget insecticide design by virtue of their similar substrate binding mode and catalytic mechanism.On the other hand,natural products with diverse skeletal structures are potential repositories of chitinolytic enzyme inhibitors.This minireview first presents the theoretical basis of developing multitargeted inhibitors against insect chitinolytic enzymes and then focuses on the progress in developing multitarget inhibitors derived from natural products.These may provide ideas for the exploitation of novel pesticide leads from natural products by targeting multiple targets. 展开更多
关键词 Multitarget inhibitors Insect chitinolytic enzymes Natural products
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SUNDER:Self-organized grouping and entrapping method for swarms in multitarget environments 认领 引用
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作者 Yutong Yuan Zhun Fan +5 位作者 Xiaomin Zhu Li Ma Ji Ouyang Weidong Bao Ji Wang Zhaojun Wang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2023年第8期68-83,共16页
For swarm robots moving in a harsh or uncharted outdoor environment without GPS guidance and global communication,algorithms that rely on global-based information are infeasible.Typically,traditional gene regulatory n... For swarm robots moving in a harsh or uncharted outdoor environment without GPS guidance and global communication,algorithms that rely on global-based information are infeasible.Typically,traditional gene regulatory networks(GRNs)that achieve superior performance in forming trapping pattern towards targets require accurate global positional information to guide swarm robots.This article presents a gene regulatory network with Self-organized grouping and entrapping method for swarms(SUNDER-GRN)to achieve adequate trapping performance with a large-scale swarm in a confined multitarget environment with access to only local information.A hierarchical self-organized grouping method(HSG)is proposed to structure subswarms in a distributed way.In addition,a modified distributed controller,with a relative coordinate system that is established to relieve the need for global information,is leveraged to facilitate subswarms entrapment toward different targets,thus improving the global multi-target entrapping performance.The results demonstrate the superiority of SUNDERGRN in the performance of structuring subswarms and entrapping 10 targets with 200 robots in an environment confined by obstacles and with only local information accessible. 展开更多
关键词 Swarm robots Local information Gene regulatory network Swarm grouping Trapping pattern Confined multitarget environment
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A Decorrelation Constant Modulus Algorithm for Multitarget Separation Using Adaptive Arrays 认领 引用
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作者 XU Jin ZHU Guoqiang YUAN Fei 《Wuhan University Journal of Natural Sciences》 CAS 2007年第6期1063-1065,共3页
In this paper, an adaptive digital filter algorithm is presented to optimize the signal-to-noise ratio of an antenna array with multiuser signal inputs. These synchronous communication signals have constant envelope p... In this paper, an adaptive digital filter algorithm is presented to optimize the signal-to-noise ratio of an antenna array with multiuser signal inputs. These synchronous communication signals have constant envelope property and are transmitted through a Multiple-Input/Multiple-Output （MIMO） linear channel. This Multiuser Constant Modulus Algorithm （MU-CMA） using an antenna array can compensate for both Interuser Interference （IUI） and Intersymbol Interference （ISI）. The method is derived by minimizing the cost function of the constant modulus signals as well as cross-correlations between them. The simulation result in this paper shows the performance of this algorithm. 展开更多
关键词 constant modulus multitarget adaptive array
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A new fast algorithm for multitarget tracking in dense clutter 认领 引用 被引量：1
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作者 Weihua QIN Fei HU Chaoyin QIN 《控制理论与应用（英文版）》 2005年第4期383-386,共4页
A fast joint probabilistic data association （FJPDA） algorithm is proposed in tiffs paper. Cluster probability matrix is approximately calculated by a new method, whose elements βi^t（K） can be taken as evaluation ... A fast joint probabilistic data association （FJPDA） algorithm is proposed in tiffs paper. Cluster probability matrix is approximately calculated by a new method, whose elements βi^t（K） can be taken as evaluation functions. According to values of βi^t（K）, N events with larger joint probabilities can be searched out as the events with guiding joint probabilities, tiros, the number of searching nodes will be greatly reduced. As a result, this method effectively reduces the calculation load and nnkes it possible to be realized on real-thne, Theoretical ,analysis and Monte Carlo simulation results show that this method is efficient. 展开更多
关键词 Data association Multitarget tracking Cluster probability matrix Search-tree
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新型多靶点抗叶酸制剂——Multitarget Antifolate(MTA) 认领 引用
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作者 王国华 张湘茹 《临床肿瘤学杂志》 CAS 2004年第4期435-437,F003,共3页
关键词 多靶点 抗叶酸制剂 Multitarget Antifolate MTA 氨甲喋呤 抗肿瘤药
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融合混合专家及多目标域对抗迁移网络的锅炉汽水系统跨工况故障诊断 认领 引用 被引量：2
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作者 马良玉 韩立凯 《中国电机工程学报》 EI CSCD 北大核心 2026年第11期4644-4656,I0021,共13页
针对火电厂不同负荷、不同控制方式下,故障标注数据缺乏、域间特征差异大导致故障诊断模型跨工况诊断能力差及传统域自适应方法多局限于单一目标域迁移的问题,提出一种融合混合专家(mixture of experts,MoE)及多目标域对抗迁移网络的锅... 针对火电厂不同负荷、不同控制方式下,故障标注数据缺乏、域间特征差异大导致故障诊断模型跨工况诊断能力差及传统域自适应方法多局限于单一目标域迁移的问题,提出一种融合混合专家(mixture of experts,MoE)及多目标域对抗迁移网络的锅炉汽水系统跨工况故障诊断方法。首先,建立以双向门控循环单元(bidirectional gated recurrent unit,BiGRU)提取故障数据潜在特征、以软注意力机制协助专注关键特征的特征提取器;然后,设置多专家网络对特征提取器的输出特征进行再处理,并通过门控网络动态加权后输出至标签分类器和领域判别器;最后,为每个目标域分别设置一个单独的领域判别器,通过梯度反转层实现对抗训练并协同最大均值差异(maximum mean discrepency,MMD)联合提取源域与多个目标域的域不变特征,同时利用源域标注数据不断训练特征提取器、MoE与标签分类器。借助某600 MW火电厂仿真机进行锅炉汽水系统故障诊断实验,表明该方法可实现同时对多个目标域的有效迁移,且各迁移任务中的域平均诊断准确率均在98%以上。 展开更多
关键词 四管泄漏 故障诊断 双向门控循环单元 软注意力机制 混合专家 对抗训练 多目标域自适应
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黄连解毒汤抗急性缺血性中风研究进展 认领 引用
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作者 董利洋 张钦渊 +8 位作者 武怡平 何颖萍 邵威 张浩嘉 王雪茜 李长香 崔友祥 程发峰 王庆国 《中国实验方剂学杂志》 CAS CSCD 北大核心 2026年第11期77-86,共10页
黄连解毒汤作为清热解毒经典方剂,近年来被广泛应用于临床各科疾病的治疗,尤其在中风火热期的应用备受关注。基于先前研究,该文将系统地从黄连解毒汤活性成分研究进展、抗缺血性中风临床应用进展及作用机制研究进展等3个方面进行具体阐... 黄连解毒汤作为清热解毒经典方剂,近年来被广泛应用于临床各科疾病的治疗,尤其在中风火热期的应用备受关注。基于先前研究,该文将系统地从黄连解毒汤活性成分研究进展、抗缺血性中风临床应用进展及作用机制研究进展等3个方面进行具体阐述。现代药理研究表明,黄连解毒汤中含有黄芩苷、栀子苷和小檗碱等多种活性成分,在针对缺血性中风疾病的治疗中,这些活性成分可通过多靶点、多途径、多层次来发挥作用。临床研究表明,黄连解毒汤可以增加缺血性中风患者的脑血流量、减少脑梗死体积、改善中风后的躯体障碍。实验研究表明,黄连解毒汤可以改善中风实验动物的神经功能评分,增加脑灌注量。此外,黄连解毒汤抗缺血性中风的作用机制可能与抗炎、抗氧化、促进血管新生及调节氨基酸代谢和能量代谢有关。尽管现有研究证实黄连解毒汤具有多靶点、多通路协同治疗特点,但仍需进一步开展大样本随机对照试验验证其长期疗效,并深入解析复方成分-靶点-通路的动态互作网络。该文结合网络药理学和分子对接分析,进一步明确了核心成分(小檗碱、黄芩苷、栀子苷)的协同作用靶点,为黄连解毒汤抗缺血性中风的深入研究和临床转化提供理论依据。 展开更多
关键词 黄连解毒汤 缺血性中风 活性成分 临床应用 实验研究 多靶点调控
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基于拦截捕获区的“多对多”能量最优目标分配方法 认领 引用
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作者 李昊键 黎克波 梁彦刚 《北京航空航天大学学报》 EI CAS CSCD 北大核心 2026年第2期490-497,共8页
针对多拦截器与多目标交战(MME)场景的任务分配问题,从制导的角度入手,提出基于拦截捕获区的“多对多”能量最优目标分配方法。分析三维现实真比例导引(3D-RTPN)拦截任意机动目标的捕获区与最优制导能量消耗;以多拦截器成功拦截机动目... 针对多拦截器与多目标交战(MME)场景的任务分配问题,从制导的角度入手,提出基于拦截捕获区的“多对多”能量最优目标分配方法。分析三维现实真比例导引(3D-RTPN)拦截任意机动目标的捕获区与最优制导能量消耗;以多拦截器成功拦截机动目标与整体能量消耗最低为优化目标,构建目标分配代价矩阵;基于适应性匈牙利算法(AHA)实现多拦截器的多目标分配(MMA)。通过数值仿真算例,验证了所提方法的有效性。 展开更多
关键词 多拦截器多目标交战 拦截捕获区 三维真比例导引 适应性匈牙利算法 多拦截器多目标分配
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一种基于双星光学观测的空间多目标跟踪方法 认领 引用
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作者 赵高鹏 王云泽 +1 位作者 薛小龙 顾冬晴 《宇航学报》 EI CAS CSCD 北大核心 2026年第5期1215-1228,共14页
针对天基光学监视中空间多目标运动特性复杂、目标个数时变以及目标高密度分布的问题,提出了一种基于双星光学观测的空间多目标跟踪方法。建立空间目标轨道动力学模型与双星光学观测模型,基于对极几何理论实现目标像点的匹配关联,完成... 针对天基光学监视中空间多目标运动特性复杂、目标个数时变以及目标高密度分布的问题,提出了一种基于双星光学观测的空间多目标跟踪方法。建立空间目标轨道动力学模型与双星光学观测模型,基于对极几何理论实现目标像点的匹配关联,完成空间目标三维位置信息解算。针对高斯混合势均衡概率假设密度(GM-CPHD)滤波算法应用于空间多目标跟踪时新生目标响应弱、紧邻目标分辨能力不足的问题,引入新生目标强度自适应估计策略与协作惩罚剪枝合并策略对算法进行改进,提升目标分辨能力与跟踪稳定性。设计目标伴飞与轨迹交叉、目标并行与自然绕飞两种典型场景开展仿真实验与分析。实验结果表明,该方法可有效应对目标数目时变、分布密集、轨迹交叉等复杂情形,能够准确估计空间目标的数量与位置信息,适用于天基光学监视下的空间多目标稳定跟踪。 展开更多
关键词 天基光学监视 空间目标 双星协同观测 多目标跟踪
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Multitarget tracking control algorithm under local information selection interaction mechanism 认领 引用
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作者 Jiehong Wu Jinghui Yang +1 位作者 Weijun Zhang Jiankai Zuo 《Intelligent and Converged Networks》 EI 2021年第2期91-100,共10页
This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unman... This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unmanned aerial vehicles(UAVs)for target tracking,a multitarget tracking control algorithm under local information selection interaction is proposed.First,on the basis of location,number,and perceived target information of neighboring UAVs,a temporary leader selection strategy is designed to realize the local follow-up movement of UAVs when the UAVs cannot fully perceive the target.Second,in combination with the basic rules of cluster movement and target information perception factors,distributed control equations are designed to achieve a rapid gathering of UAVs and consistent tracking of multiple targets.Lastly,the simulation experiments are conducted in two-and three-dimensional spaces.Under a certain number of UAVs,clustering speed of the proposed algorithm is less than 3 s,and the equal probability of the UAV subgroup size after group separation is over 78%. 展开更多
关键词 multitarget tracking time-consuming grouping local information selection interaction temporary leader selection strategy subgroup size
Stability analysis for delayed viral infection model with multitarget cells and general incidence rate 认领 引用
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作者 Jinliang Wang Xinxin Tian Xia Wang 《International Journal of Biomathematics》 SCIE 2016年第1期135-155,共21页
In this paper, the sharp threshold properties of a （2n ＋ 1）-dimensional delayed viral infection model are investigated. This model combines with n classes of uninfected tar- get cells, n classes of infected cells a... In this paper, the sharp threshold properties of a （2n ＋ 1）-dimensional delayed viral infection model are investigated. This model combines with n classes of uninfected tar- get cells, n classes of infected cells and nonlinear incidence rate h（x,v）. Two kinds of distributed time delays are incorporated into the model to describe the time needed for infection of uninfected target cells and virus replication. Under certain conditions, it is shown that the basic reproduction number is a threshold parameter for the existence of the equilibria, uniform persistence, as well as for global stability of the equilibria of the model. 展开更多
关键词 Viral infection model multitarget cells nonlinear incidence rate global stabi-lity Lyapunov functional.
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中医药靶向调控炎症相关信号通路防治动脉粥样硬化的研究进展 认领 引用 被引量：6
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作者 赵爽 张明雪 +3 位作者 刘宁 苏嘉楠 敖玉涵 李京 《中国实验方剂学杂志》 CAS CSCD 北大核心 2026年第3期273-283,共11页
动脉粥样硬化(AS)是心血管疾病的主要病理基础,严重威胁人类生命质量,其防治亟待突破。炎症反应贯穿AS的生理和病理演变过程,是其发生的重要机制之一。目前,西医治疗AS方式较成熟,但存在肝肾功能异常、药物耐受、靶血管再狭窄及支架内... 动脉粥样硬化(AS)是心血管疾病的主要病理基础,严重威胁人类生命质量,其防治亟待突破。炎症反应贯穿AS的生理和病理演变过程,是其发生的重要机制之一。目前,西医治疗AS方式较成熟,但存在肝肾功能异常、药物耐受、靶血管再狭窄及支架内血栓形成等不良反应,仍是制约临床疗效的关键瓶颈。中医药凭借其多成分、多靶点、多通路协同作用的特点,在干预AS方面展现出独特的临床应用潜力和疗效优势。该文系统综述近5年中医药通过调控核转录因子-κB(NF-κB)、Toll样受体(TLRs)、丝裂原活化蛋白激酶(MAPK)、酪氨酸激酶/信号转导子和转录激活子(JAK/STAT)等炎症相关信号通路干预AS的研究进展,总结中药单体、中药药对及复方制剂通过多靶点协同抑制炎症级联反应、调节脂质代谢紊乱、改善血管内皮功能障碍与微环境失衡的综合作用机制,深化中医药抗AS的分子机制研究,以期为中医药抗AS的临床转化应用及相关理论研究提供科学依据。 展开更多
关键词 中医药 动脉粥样硬化 炎症信号通路 分子机制 多靶点调控
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从靶向修复到生态重塑的皮肤衰老机制与中药抗衰策略探索 认领 引用
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作者 毛婷 肖莲莲 +7 位作者 朱浩 吕红燕 吴媛媛 陈利 陈斌 聂韡 邹伟 陆茵 《南京中医药大学学报》 CAS CSCD 北大核心 2026年第7期1103-1112,共10页
皮肤衰老是内源性生理衰退与外源性环境胁迫协同作用下,皮肤生态系统稳态进行性崩塌的复杂生物学过程,中医药整体调控、多维协同干预的特点,在抗皮肤衰老中的应用日益凸显。本文立足动态“衰老微环境”视角,系统剖析了细胞间通讯、脉管... 皮肤衰老是内源性生理衰退与外源性环境胁迫协同作用下,皮肤生态系统稳态进行性崩塌的复杂生物学过程,中医药整体调控、多维协同干预的特点,在抗皮肤衰老中的应用日益凸显。本文立足动态“衰老微环境”视角,系统剖析了细胞间通讯、脉管系统、皮肤微生态、力学信号传导、表观遗传重塑及神经-内分泌轴等多维度的衰老调控机制,阐述了抗衰策略从“单一成分靶向”迈向“系统生态调控”的必然趋势,重点探讨了中药“多成分-多靶点-多途径”的系统生物学内涵,特别是“中药暗物质”(如植物源小核酸)、中药后生元及药食同源理念在系统重塑皮肤衰老微环境中的独特机制与应用潜力。展望了人工智能、单细胞测序等前沿技术与中西医理论深度融合的未来发展趋势,旨在为构建下一代多靶点、系统性的智能抗衰体系提供理论支撑。 展开更多
关键词 皮肤衰老 衰老微环境 中药抗衰 系统调控 暗物质 人工智能 多靶点
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补阳还五汤调控NOS3及F5改善AIS-LVO患者疗效的机制 认领 引用
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作者 马磊 王东峰 +4 位作者 蒋欣 李振强 叶耿帆 王丽娜 陈茂送 《浙江临床医学》 2026年第4期499-501,共3页
目的基于网络药理学与临床样本验证,探讨补阳还五汤干预急性大血管闭塞性缺血性脑卒中(AIS-LVO)的潜在分子机制,分析其对血管内皮功能与凝血调控相关核心靶点NOS3和F5的调控作用。方法基于TCMSP、SwissTargetPrediction、OMIM和GeneCard... 目的基于网络药理学与临床样本验证,探讨补阳还五汤干预急性大血管闭塞性缺血性脑卒中(AIS-LVO)的潜在分子机制,分析其对血管内皮功能与凝血调控相关核心靶点NOS3和F5的调控作用。方法基于TCMSP、SwissTargetPrediction、OMIM和GeneCards数据库筛选补阳还五汤的活性成分及其潜在作用靶点,构建“中药-活性成分-靶点”网络,并对核心靶点进行KEGG与GO富集分析以解析潜在作用通路。开展单中心、随机、对照、开放标签的前瞻性临床试验,纳入符合条件的AIS-LVO患者60例,随机分为常规治疗对照组和补阳还五汤联合常规治疗观察组(各30例),采用ELISA检测两组患者治疗前后血清NOS3与F5水平,对网络药理学预测结果进行临床验证。结果网络药理学分析共筛选获得182种活性成分,药物靶点与AIS-LVO疾病靶点交集后获得NOS3与F5为核心作用靶点。KEGG富集分析显示,关键靶点与血管内皮功能、凝血稳态、炎症反应及缺血-再灌注损伤相关通路密切相关。GO富集分析进一步表明,核心靶点主要参与凝血与止血、血栓形成、血管结构与功能调控、氧化应激、炎症反应及组织修复等生物过程。临床样本验证结果显示,观察组治疗后血清NOS3水平显著升高(P<0.05)、F5水平显著降低(P<0.05),变化方向与网络药理学预测高度一致。结论补阳还五汤可能通过多成分-多靶点-多通路协同作用,以上调NOS3、下调F5为关键枢纽,综合调控血管舒张、内皮保护、凝血平衡及炎症反应,从而干预AIS-LVO的发生与进展。 展开更多
关键词 补阳还五汤 急性大血管闭塞性缺血性脑卒中 网络药理学 NOS3 F5 多靶点治疗 中西医结合
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经颅光生物调节干预阿尔茨海默病的临床研究进展 认领 引用
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作者 付洁 高致冰 +5 位作者 贾海 刘斯琪 李华柏 张龙 李智林 赵晨光 《激光生物学报》 CAS 2026年第2期149-161,I0001-I0009,共13页
阿尔茨海默病(AD)作为一种复杂的神经退行性疾病,亟需多靶点、个性化的治疗策略。经颅光生物调节(tPBM)作为一种非侵入性物理调控手段,通过近红外光穿透颅脑,靶向调控线粒体功能、神经血管单元及类淋巴系统等多重病理环节,兼具代谢调节... 阿尔茨海默病(AD)作为一种复杂的神经退行性疾病,亟需多靶点、个性化的治疗策略。经颅光生物调节(tPBM)作为一种非侵入性物理调控手段,通过近红外光穿透颅脑,靶向调控线粒体功能、神经血管单元及类淋巴系统等多重病理环节,兼具代谢调节与神经调控双重特性,展现出与主流生物药物开发策略[如β-淀粉样蛋白(Aβ)清除、炎症调节]高度契合的多靶点干预潜力。本文重点对纳入的42项临床研究进行了分析,包括样本特征、干预参数及临床疗效,并系统梳理了tPBM在AD干预中的机制研究、临床研究证据与剂量学方法,强调其在家用化、可穿戴化方向的发展趋势,并初步提出从“经颅光剂量学”到“生物学效应”的转化路径。未来,通过构建个体化光子剂量-响应模型、融合实时生理反馈与脑影像导航,tPBM有望实现从群体有效性向个体化治疗的跨越,成为AD协同治疗与长期管理的重要非药物干预手段。 展开更多
关键词 阿尔茨海默病 经颅光生物调节 剂量学 多靶点治疗 神经调控
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