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Advances in natural product discovery:strategies,technologies,and insights 认领 引用
1
作者 Buddha Bahadur Basnet Zhen-Yi Zhou +2 位作者 Rajesh Basnet Bin Wei Hong Wang 《Natural Products and Bioprospecting》 CSCD 2026年第1期39-79,共41页
Natural products(NPs)and their analogues have long underpinned therapies in humans,animals,and plants health,yet,discovering truly novel scaffolds remains a formidable challenge,even with the enormous diversity offere... Natural products(NPs)and their analogues have long underpinned therapies in humans,animals,and plants health,yet,discovering truly novel scaffolds remains a formidable challenge,even with the enormous diversity offered.Over the last two decades,breakthroughs in bioinformatics,cheminformatics,advanced analytical methods,synthetic biology toolkits,and optimized microbial culture have surmounted many of the bottlenecks that stalled NP research in the 1990s and 2000s.Researchers now deploy innovative extraction and purification protocols alongside high-throughput dereplication tools to fish trace metabolites out of complex matrices.These combined approaches not only enable the discovery and rigorous characterization of biosynthesized metabolites,bio-transformed ana-logues and new chemical entities but also allow precise tuning of biosynthetic gene clusters(BGCs)and culture conditions-modulation and optimization,dramatically improving yield,scalability,and cost-efficiency.Several of these newly unearthed compounds exhibit unique bioactivities that directly inspire drug-development programs against metabolic disorders,cancer drug resistance,and infectious diseases.In this review,we present an up-to-date,concise roadmap of natural product discovery(NPD),majorly covering strategies for awakening silent BGCs,genome mining,and late-stage diversification systems,and we discuss the current limitations and perspectives of rational NPD. 展开更多
关键词 Natural products Culturing modulation Unexplored reservoirs Genome mining Natural product diversification
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A scheme of terrestrial system of Pakistan and the utilization and protection of its natural resources 认领 引用
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作者 WU Shaohong XIN Keying +3 位作者 SU Fenghuan LIU Lulu JIANG Ning CUI Peng 《Journal of Geographical Sciences》 SCIE CSCD 2026年第6期1369-1400,共32页
The comprehensive pattern of the natural environment constitutes a complex system shaped by interactions among multiple natural elements,including geology,terrain,climate,hydrology,soil,and biodiversity.The regional s... The comprehensive pattern of the natural environment constitutes a complex system shaped by interactions among multiple natural elements,including geology,terrain,climate,hydrology,soil,and biodiversity.The regional structure that embodies this complexity is defined as the comprehensive natural terrestrial system.Consequently,this system provides an integrated perspective for understanding the overall characteristics of the natural environment and resources.Pakistan,with agriculture as its core economic sector,has a natural environment that is inherently linked to its topographic and climatic conditions.Its geographical environmental conditions are similar to those of China.Through analysis of Pakistan's geological,geomorphological,climatological,hydrological,and vegetation conditions,we adopted the methodology of China's comprehensive natural regionalization to establish a comprehensive natural terrestrial system scheme for Pakistan.Hierarchically,this scheme is divided into 3 major regions,5 temperature zones,8 humidity areas,and 23 natural regions.The scheme reveals the diversity of Pakistan's natural environment and its three-dimensional geographical zonality characteristics.Furthermore,this study analyzes the ecological advantages,constraints,and resource development potential of each regional unit and proposes targeted strategies for ecological conservation and socioeconomic development.The scheme provides a scientific basis for the sustainable socioeconomic development of Pakistan. 展开更多
关键词 comprehensive natural terrestrial system geographic zonality natural resources utilization and protection Pakistan
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Modulation of mitochondrial dysfunction:Mechanisms and strategies for the use of natural products to treat stroke 认领 引用 被引量：3
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作者 Na Qin Rujuan Liu +3 位作者 Rong Deng Liuliu Shi Lei Wang Ting Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2215-2226,共12页
Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop... Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alphauclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs. 展开更多
关键词 apoptosis autophagy hemorrhagic stroke ischemic stroke mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction modulations mitochondrial transport natural products oxidative stress
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Natural weathering and plant regeneration accelerate soil restoration of fine particle mine tailings 认领 引用 被引量：1
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作者 Delong Meng Yu Liu +12 位作者 Xiaohui Huang Jing Wen Teng Zhang Huaqun Yin Ling Xia Wenyi Liu Jing Xiong Xing Li Zhenghua Liu Xiangdong Xiao Ibrahim Ahmed Ibrahim Xueduan Liu Min Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期388-398,共11页
Tailings pedogenesis plays a fundamental role in the ecological restoration of mining wastelands by converting barren tailings into soil-like substrates through physical,chemical,and biological processes.To systematic... Tailings pedogenesis plays a fundamental role in the ecological restoration of mining wastelands by converting barren tailings into soil-like substrates through physical,chemical,and biological processes.To systematically investigate the contributions and interactions of natural weathering and plant regeneration in the tailings pedogenesis,this study analyzed the microstructure,chemical composition,and rhizosphere microbial communities of original tailings samples(OR),15-year naturally weathered samples(PW),and naturally regenerated samples spontaneously colonized by Miscanthus(PM),Lolium perenne(LP),and Cynodon dactylon(CD).X-ray micro-computed tomography revealed that natural weathering increased the total soil porosity of the tailings by 13.45%,with negligible effects on chemical properties.After natural regeneration,soil porosity further increased from 18.74%to 41.45%.Scanning Electron Microscope revealed microaggregates attaching to the root surfaces.In addition,plant species exhibited distinct influences on soil chemical properties.Specifically,PM significantly increased soil organic matter and nitrate nitrogen content,whereas CD primarily promoted the accumulation of rapidly available potassium.Compared to the OR,natural weathering initiated the reconstruction of microbial communities,which were further enriched by plant root systems during natural regeneration.Notably,PM enriched functional genera such as Haliangium and Bryobacter,which were positively associated with heavy metal stabilization,suggesting its role as a critical pioneer species for ecological restoration of tailings.This study highlights the distinct and synergistic roles of natural weathering and plant regeneration in tailings pedogenesis,offering insights for plant selection and ecological restoration strategies. 展开更多
关键词 Natural weathering Plant regeneration Tailings Microorganisms Soil microstructure
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Screening of tyrosine phosphatase SHP2(PTPN11)inhibitors from natural products with therapeutic potential for receptor tyrosine kinase-driven cancer 认领 引用 被引量：1
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作者 Lingfeng Chen Di Ke +4 位作者 Zheng Jiang Ruixiang Luo Jie Li Lulu Zheng Guang Liang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期488-499,共12页
Src homology 2 domain-containing phosphatase 2(SHP2)is a pivotal regulator linking receptor tyrosine kinase(RTK)signaling.Abnormal SHP2 activity has been associated with tumorigenesis and metastasis.Although some SHP2... Src homology 2 domain-containing phosphatase 2(SHP2)is a pivotal regulator linking receptor tyrosine kinase(RTK)signaling.Abnormal SHP2 activity has been associated with tumorigenesis and metastasis.Although some SHP2-targeting modulators have entered clinical trials,U.S.Food and Drug Administraction(FDA)-approved SHP2 targeting drugs are still not available.Herein,we describe cooperative biochemical inhibition experiments that facilitate the identification of both catalytic and allosteric SHP2 inhibitors using an in-house natural product(NP)library.Based on this screening methodology,structurally diverse sets of NPs were characterized,among which dihydrotanshinone I(DHT)potently inhibited the wild-type SHP2 protein tyrosine phosphatase(PTP)domain and gain-of-function SHP2 variants.Trichostatin A(TSA)bound to the“tunnel”binding site,acting as an allosteric inhibitor.This study illustrates an optimized screening methodology and tactics to identify novel SHP2 modulators from NPs and provides a foundation for further NP-based drug development for the treatment of RTK-driven cancer. 展开更多
关键词 SHP2 High-throughput screening Lead compound Natural products Allosteric inhibitor
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Synthesis,function,and application of plant-derived natural products in food 认领 引用
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作者 Linshan Li Chi Shu +5 位作者 Jinlong Tian Wenwen Zeng Liang Wang Zhenyu Wang Qiuwei Zhao Bin Li 《Food Innovation and Advances》 2026年第1期13-25,共13页
Natural products are widely distributed across various organisms,and exhibit potent physiological activities.Among these,plant-derived natural products are extensively utilized in the food,pharmaceutical,and healthcar... Natural products are widely distributed across various organisms,and exhibit potent physiological activities.Among these,plant-derived natural products are extensively utilized in the food,pharmaceutical,and healthcare industries.Traditional extraction methods primarily rely on plant extraction but suffer from drawbacks such as low yield,long growth cycles,and high resource consumption.Consequently,microbial fermentation technology has emerged as an alternative solution,offering advantages including the ability to utilize abundant raw materials and its environmentally friendly and sustainable characteristics.This review summarizes recent advances in the biosynthesis and functional mechanisms of four classes of plant-derived natural products—alkaloids,terpenoids,phenylpropanoids,and polysaccharides—while also examining the challenges and future prospects for their practical applications. 展开更多
关键词 biosynthesis natural products plant extraction alkaloids terpenoids plant derived natural products microbial fermentation fermentation technology
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Numerical study of a quantum spin in an s-wave superconductor using the natural orbitals renormalization group method 认领 引用
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作者 Wen-Jing Zhang Ru Zheng +1 位作者 Rong-Qiang He Zhong-Yi Lu 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第2期538-547,共10页
In a superconductor embedded with a quantum magnetic impurity,the Kondo effect is involved,leading to the competition between the Kondo singlet phase and the superconductivity phase.By means of the natural orbitals re... In a superconductor embedded with a quantum magnetic impurity,the Kondo effect is involved,leading to the competition between the Kondo singlet phase and the superconductivity phase.By means of the natural orbitals renormalization group(NORG)method,we revisit the problem of a quantum magnetic impurity coupled with a conventional s-wave superconductor.Here we present a detailed study focusing on the impurity spin polarization and susceptibility,the Kondo screening cloud,as well as the number and structures of the active natural orbitals(ANOs).In the superconducting phase,the impurity spin is partially polarized,indicating that the impurity remains partially screened by the quantum fluctuations.Furthermore,the impurity spin susceptibility becomes divergent,resulting from the presence of residual local moment formed at the impurity site.Correspondingly,a non-integral(incomplete)Kondo cloud is formed,although the ground state is a spin doublet in this phase.In comparison,the Kondo cloud is complete in the Kondo singlet phase as expected.We also quantify the critical point,where the quantum phase transition from a Kondo singlet phase to a superconducting phase occurs,which is consistent with that in previous works.On the other hand,it is illustrated that only one ANO emerges in both quantum phases.The structures of the ANO,projected into both the real space and momentum space,are distinct in the Kondo singlet phase from that in the superconducting phase.More specifically,in the Kondo singlet phase,the ANO keeps fully active with half-occupied,and the superconducting gap has negligible influence on its structure.On the contrary,in the superconducting phase,the ANO tends to be inactive and its structure changes significantly as the superconducting gap increases.Additionally,our investigation demonstrates that the NORG method is reliable and convenient to solve the quantum impurity problems in superconductors as well,which will promote further theoretical studies on the Kondo problems in such systems using numerical methods. 展开更多
关键词 Kondo effect superconductor natural orbitals renormalization group active natural orbitals
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Development of a piezoresistive accelerometer with both high natural frequency and superior overload capability 认领 引用
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作者 Yong Xia Xinyao Meng +8 位作者 Yang Lv Xiangguang Han Zhixia Qiao Mingzhi Yu Chen Jia Qing Zhang Ping Yang Dejiang Lu Libo Zhao 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第7期186-197,共12页
Accelerometers featuring high natural frequencies and superior overload capabilities are particularly valuable in applications such as military low-threshold-weapon fuzes.However,synergistic improve-ment of these para... Accelerometers featuring high natural frequencies and superior overload capabilities are particularly valuable in applications such as military low-threshold-weapon fuzes.However,synergistic improve-ment of these parameters is bottlenecked by the trade-off between sensitivity and natural frequency,and the trade-off between natural frequency and displacement limit.Here,via designing anti-overload structures integrated with the pure-axial-stressed sensing structure,we achieve simultaneous high natural frequency and superior overload capability.The proposed sensor is fabricated and characterized.Results yield a sensitivity of 0.037±0.002 mV/g at 2 V and a natural frequency of 31.35±0.72 kHz,comparable to the reference sensor,and an overload capability of 19445.80±290.55 g representing a 133.84%improvement.Accelerometers with high natural frequency and superior overload capability enable high-fidelity measurement of broadband signals under harsh environments. 展开更多
关键词 Piezoresistive accelerometer Anti-overload structures Pure-axial-stressed sensing structure Natural frequency Overload capability
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Astrocytes:Unveiling their role in the molecular mechanism of natural antidepressants 认领 引用
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作者 Shimeng Lv Ruirui Shang +9 位作者 Xia Zhong Yitong Lu Haonan Gao Guangheng Zhang Linghui Kong Yunhao Yi Yufei Huang Yuexiang Ma Jing Teng Sheng Wei 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期637-655,共19页
Depression,an emotional disorder characterized by persistent low mood and loss of pleasure,can be alleviated by mainstream clinical drugs(such as selective serotonin reuptake inhibitors).However,issues such as delayed... Depression,an emotional disorder characterized by persistent low mood and loss of pleasure,can be alleviated by mainstream clinical drugs(such as selective serotonin reuptake inhibitors).However,issues such as delayed efficacy,significant individual differences,and adverse reactions remain.Compared to traditional single-target drugs,natural products have shown unique potential in depression intervention due to their synergistic multi-component effects and multi-target,multi-pathway regulation.As the most abundant glial cells in the central nervous system,astrocytes are deeply involved in the pathology of depression and have become important targets for the antidepressant effects of natural products.Although existing studies have revealed the regulatory effects of natural products on the function of astrocytes,there is still a lack of systematic categorization and mechanism integration.This review comprehensively summarized the molecular mechanisms by which natural products regulated astrocyte function through a systematic literature review,objectively analyzes key bottlenecks in current translational research,and aims to provide a theoretical basis and technical pathway for optimizing depression treatment paradigms and promoting the clinical translation of natural product research. 展开更多
关键词 Astrocyte Depression Natural product Molecular mechanism Clinical translation
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Optimizing a multimedia model to assess the differential roles of crops and natural vegetation in the fate of PAHs 认领 引用
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作者 Chao Su Danfeng Zheng +7 位作者 Wenlei Chen Kifayatullah Khan Hong Zhang Shuai Song Ruoyu Liang Xiaoyu Zhang Yong Liu Xianghui Cao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第1期413-423,共11页
Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we ... Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we developed the BETR-Urban-Rural-Veg model to quantitatively evaluate the influences of both natural vegetation and crops on the multimedia transport processes of Phenanthrene(PHE)and Benzo(a)pyrene(BaP)in mainland of China.The geographic distribution of polycyclic aromatic hydrocarbon(PAH)emissions and concentrations were consistent,displaying higher levels in northern China while lower levels in southern China.Under seasonal simulations,for both natural vegetation and crops,PAH concentrations in winter and spring were 1.5 to 27-fold higher than in summer and autumn,especially for PHE.Owing to the higher leaf area index(LAI)of natural vegetation and harvesting of crops,the filter and sequestration effect of natural vegetation was stronger than crops,while the seasonal changes of PAH concentrations in crops were more significant than natural vegetation.Temperature,precipitation rates and LAI might have important influences on seasonal concentrations and overall persistence of PAHs.PHE was more sensitive to the impacts of seasonal environmental parameters.Under different landscape scenarios,average annual PAH concentrations in natural vegetation were always a little higher than those in crops,and the overall persistence of BaP was greatly affected increasing by 15.15%-16.47%.This improved model provides a useful tool for environmental management.The results of this study are expected to support land use plans and decision-making in China's mainland. 展开更多
关键词 Multimedia fate model Natural vegetation Crops Seasonal variabilities Landscape scenarios
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Pharmacological mechanisms of natural products with antidepressant effects:A focus on the programmed cell death regulation 认领 引用
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作者 Guangheng Zhang Shimeng Lv +9 位作者 Shengchuan Bao Weijie Zhao Yunhao Yi Haonan Gao Xia Zhong Xiangyu Li Fengzhao Liu Yitong Lu Siyuan Sun Jing Teng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期120-141,共22页
Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increase... Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increased,making it the second-largest global health burden.The pathogenesis of depression involves a series of complex pathological mechanisms,although the key underlying causes remain unclear.Programmed cell death(PCD),including apoptosis,autophagy,pyroptosis,ferroptosis,and necroptosis,involves highly organized gene expression processes that may influence the occurrence and development of depression by regulating cellular fate.Furthermore,numerous studies have shown that natural products can modulate PCDs through various signaling pathways,presenting significant potential for managing depression.Natural products offer benefits such as cost-effectiveness,fewer side effects,and other advantages,making them viable supplements or alternatives to traditional antidepressant drugs.To explore this potential,we reviewed studies demonstrating the antidepressant effects of natural products through multi-target modulation of PCDs.In addition,we discussed the toxicity and clinical applications of these natural products.This study highlights that diverse core biological pathways and targets are involved in determining the fate of depression-associated brain cells,including the PI3K/Akt signaling pathway,caspase-8,GSDMD,and others.In conclusion,the multi-target mechanisms of PCD regulation by natural products may provide a promising foundation for the future development of novel antidepressant medications. 展开更多
关键词 Depression Pharmacological mechanism Programmed cell death Natural products Antidepressant
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Prevention and treatment of knee osteoarthritis by natural products:potential mechanisms based on articular cartilage targets 认领 引用
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作者 Qitao Ye Kangyu Zhou +5 位作者 Qingqi Gao Chengyan Li Yunjie Sheng Li Zou Chaoying Tong Dan Shou 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第2期129-144,共16页
Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence ... Knee osteoarthritis(KOA)is a prevalent chronic degenerative joint disorder characterized by an imbalance between articular cartilage degradation and synthesis,a central mechanism in KOA pathogenesis.Given the absence of disease-modifying therapies,there is a critical need to elucidate the underlying pathological processes,establish reliable biomarkers for early detection and prognosis,and identify safer,more effective therapeutic agents.In recent years,natural products have attracted considerable interest due to their low toxicity,cost-effectiveness,and distinct biological activities,demonstrating significant potential in KOA management.These compounds can impede KOA progression through multiple mechanisms,including promoting cartilage matrix synthesis,mitigating inflammation,reducing oxidative stress,suppressing chondrocyte apoptosis,and modulating autophagy,thereby supporting their translational application.This review summarizes biomarkers relevant to early diagnosis and phenotypic stratification in KOA,with a focus on elucidating the pharmacological actions and molecular mechanisms of natural products,such as flavonoids,alkaloids,saponins,terpenes,and traditional Chinese medicine(TCM)formulas,in KOA intervention,aiming to provide evidence-based strategies for improved disease management. 展开更多
关键词 Knee osteoarthritis Cartilage Natural products Pharmacotherapies Biomarkers
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Geochemical characteristics and sources of natural gas in the Upper Paleozoic limestone strata,Ordos Basin 认领 引用
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作者 Wen Zhang Qian-Ping Wang +9 位作者 Wen-Hui Liu Ping-Ping Shi Hou-Yong Luo Peng Liu Xiao-Yan Chen Qian Zhang Xiao-Feng Wang Dong-Dong Zhang Yi-Ran Wang Fu-Qi Li 《Petroleum Science》 SCIE EI CAS CSCD 2026年第2期582-595,共14页
The discovery of high-yield industrial gas flows in the limestone layer of the Permian Taiyuan Formation in the Ordos Basin highlights promising pro spects for natural gas exploration and has positioned this region as... The discovery of high-yield industrial gas flows in the limestone layer of the Permian Taiyuan Formation in the Ordos Basin highlights promising pro spects for natural gas exploration and has positioned this region as a key explo ration area.Howeve r,research on the origin and distribution of natural gas in the Taiyuan Limestone Formation,especially its hydrocarbon generation potential and whether these organically enriched limestones can serve as effective source rocks,remains limited.In this study,we aimed to analyse the composition and carbon isotopes of the Upper Palaeozoic Taiyuan Limestone Formation natural gas,including propanespecific isotopes.The isotopic data were compared with coal-type gases from the corresponding strata and oil-type gases from the Lower Palaeozoic carbonate strata.Natural gas in the Upper Palaeozoic Taiyuan Limestone Formation was markedly distinct from the'self-generated and self-accumulated'oil-type gas in the Lower Palaeozoic subsalt strata,indicating no obvious correlation between the two gases.The results did not support the notion that large-scale natural gas accumulations in the Lower Palaeozoic carbonate formations could be originated from Upper Palaeozoic limestone source rocks.The natural gas in the Upper Palaeozoic Taiyuan Limestone Formation was highly consistent with the typical coal-type gas from the Upper Paleozoic.The geochemical characteristics of the natural gas in the region were consistent with that of conventional natural gas,the position-specific isotopic composition of propaneΔC-T values had a narrow,positive.This showed that the gas in the Taiyuan Limestone Formation was derived from typeⅢkero gen,and propane mainly generated through the n-C3H7free radical pathway.Geochemical analyses of the Taiyuan Limestone source rocks,such as the determination of total organic carbon,kerogen carbon isotopes,organic macerals.Combined with the geochemical analysis of natural gas,it revealed low abundance of organic matter but good kerogen types,predominantly typeⅡ-Ⅲ,at a late to high-maturity evolution stage.Although the formation had certain hydrocarbon generation potential,it falls short of the hydrocarbon generation capacity of the Carboniferous-Permian coal measure source rocks.At present,there is no large-scale hydrocarbon generatio n,and it is not enough to provide hydrocarbon for the Lower Paleozoic. 展开更多
关键词 Taiyuan Formation Natural gas Position-specific carbon isotope Geochemical characteristics Ordos Basin
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Nanotechnology-based natural remedies:Advancing inflammatory bowel disease treatment through targeted drug delivery 认领 引用
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作者 Luqing Zhao Dan Dou +5 位作者 Di Zhang Shuqing Wang Xihan Zhu Ning Ding Shengsheng Zhang Chao Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期92-100,共9页
Inflammatory bowel disease(IBD),which includes Crohn's disease and ulcerative colitis,represents a significant health challenge due to its intricate interplay of genetic,environmental,and immunological factors.Whi... Inflammatory bowel disease(IBD),which includes Crohn's disease and ulcerative colitis,represents a significant health challenge due to its intricate interplay of genetic,environmental,and immunological factors.While current treatments are effective at managing symptoms,they are not without drawbacks,such as potential side effects,the financial strain on patients,and the risk of complications.Nanotechnology presents an innovative solution to these challenges,offering the potential to improve the bioavailability,stability,and precise delivery of natural compounds with potent anti-inflammatory properties.This review examines the array of nanoparticle(NP)delivery systems that are revolutionizing IBD treatment,including lipid-based NPs,polymeric NPs,metallic NPs,plant-derived exosomes,and mesoporous silica NPs.Furthermore,the review explores the various responsive mechanisms of NPs,including p H-responsive,reactive oxygen species(ROS)-responsive,enzyme-responsive,charge-mediated,ligand-receptor targeted,and multi-responsive systems.The therapeutic potential of nanomedicines derived from natural products is highlighted,with a focus on their roles in immunomodulation,reducing inflammation,repairing the intestinal barrier,and modulating the gut microbiota.Nanotechnology boosts IBD treatment with novel natural NPs.NPs delivery systems offer notable benefits,such as improving drug solubility,increasing the efficiency of absorption,alongside providing a controlled and sustained release of therapeutic agents directly at the inflammation site.Despite the promising capabilities of nanotechnology in IBD treatment,obstacles remain.These include the necessity for comprehensive toxicological assessments,formulating strategies to guarantee the safety and effectiveness of these innovative treatments.Therefore,this review provides a systematic analysis that provides guidance for the research and development of NPs based natural products. 展开更多
关键词 Inflammatory bowel disease Natural product nanomaterials Colon targeting Drug delivery system Therapeutic mechanisms
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Research on the prediction model of effective thermal conductivity of marine natural gas hydrate reservoirs based on machine learning 认领 引用
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作者 Kefeng Yan Jiajia Yan +5 位作者 Ting Huang Minghang Mao Xiaosen Li Zhaoyang Chen Weixin Pang Rui Qin 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第4期94-103,共10页
The process of exploiting natural gas hydrates involves complex phase changes,multiphase seepage,and intricate heat transfer processes.A comprehensive understanding of the heat transfer characteristics in natural gas ... The process of exploiting natural gas hydrates involves complex phase changes,multiphase seepage,and intricate heat transfer processes.A comprehensive understanding of the heat transfer characteristics in natural gas hydrate reservoirs is crucial for enhancing their exploitation efficiency.However,at present,there is a limited amount of research on the effective thermal conductivity(ETC)of complex component systems in marine natural gas hydrate reservoirs,which directly restricts the optimization of natural gas hydrate exploitation technologies in marine sediments.This study proposes a method to predict the ETC of marine natural gas hydrate reservoirs based on machine learning(ML).This method constructed an ETC dataset under the conditions including reservoir environmental characteristics(temperature,pressure,salt concentration),reservoir physical property characteristics(quartz sand content,montmorillonite content,illite content),and reservoir structural characteristics(initial water saturation,hydrate saturation,component phase).In this work,a dataset containing 200 data points from various literature was compiled.Six ML models were employed to predict the ETC of the reservoirs based on this dataset with a high-precision ETC prediction model being derived through ML training.The SHapley Additive ex Planations(SHAP)method was subsequently applied to conduct interpretability analysis on the model prediction results.This has not only confirmed the model's reliability but also quantitatively highlighted the sensitivity of key reservoir characteristics to ETC.The research results show that the Gradient Boosting Decision Tree(GBDT)model is particularly effective for predicting the ETC of marine natural gas hydrate reservoirs,as evidenced by its coefficient of determination(R2)exceeding 0.95.Sensitivity analysis reveals that the reservoir's salt concentration and illite content are the primary determinants of its overall ETC.The prediction method established in this study can provide effective technical support for the real-time evaluation of reservoir ETC during the on-site exploitation of marine natural gas hydrate reservoirs. 展开更多
关键词 Marine natural gas hydrate reservoir Effective thermal conductivity Machine learning Hydrate Heat transfer Computer simulation
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Suppressing negative natural aging effect in automotive AlMgSiCu alloys via Sn microalloying 认领 引用
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作者 Xuemei Xiang Yuxiang Lai +2 位作者 Guisen Chen Cuilan Wu Jianghua Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第6期2006-2015,共10页
Although Sn has been established as an effective microalloying element for suppressing the negative natural aging(NA)effect in Al-Mg-Si alloys,its potential to mitigate the negative NA effect in Al-Mg-Si-Cu alloys rem... Although Sn has been established as an effective microalloying element for suppressing the negative natural aging(NA)effect in Al-Mg-Si alloys,its potential to mitigate the negative NA effect in Al-Mg-Si-Cu alloys remains to be confirmed.This study system-atically investigated the role of Sn in the NA of Al-Mg-Si-Cu alloys through hardness measurements,differential scanning calorimetry,and atomic-resolution high-angle annular dark-field scanning transmission electron microscopy.Our results demonstrate that the addition of Sn significantly suppresses the adverse impact of NA on the peak-aged hardening capacity during subsequent artificial aging and sub-stantially alleviates early-stage hardening kinetics degradation.Our findings suggest that Sn modifies the nature of the NA clusters in Al-Mg-Si-Cu alloys.A significant proportion of NA clusters in the Sn-added alloy effectively served as heterogeneous nucleation sites for strengthening the precipitates during artificial aging,thereby preserving the precipitate nucleation rates and preventing coarsening at the peak-aging stage.Atomic-resolution energy-dispersive X-ray spectroscopy revealed preferential occupation of Si atomic sites by Sn atoms within theβ′and C/Q′phases.This investigation provides critical theoretical insights for optimizing alloy design in automotive-body aluminum applications. 展开更多
关键词 AlMgSiCu alloys microalloying natural aging precipitation transmission electron microscopy
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Numerical investigation of natural gas-enhanced autothermic pyrolysis for optimizing in-situ conversion in oil shale 认领 引用
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作者 Chao-Fan Zhu Tan-En Jiang +3 位作者 Shan-Shan Yao Jia-Zong Li Rui Jia Wei Guo 《Petroleum Science》 SCIE EI CAS CSCD 2026年第2期762-776,共15页
The autothermic pyrolysis in-situ conversion process for oil shale(ATS)offers the advantages of low development costs and the capability to exploit deep oil shale resources.However,oil shale formations with low oil co... The autothermic pyrolysis in-situ conversion process for oil shale(ATS)offers the advantages of low development costs and the capability to exploit deep oil shale resources.However,oil shale formations with low oil content encounter the challenge of insufficient heat-generating donors in the thermal cracking residue,making it difficult to sustain the autogenous thermal reaction through oxidative exotherm.In this study,we propose a natural gas-assisted autogenous thermal in-situ conversion technology(H-ATS)designed to develop low oil content shale,and we analyze its mechanism through numerical simulation across oil shales with varying oil contents.The results show that introducing 2.0%natural gas into the injected air successfully triggers the autogenous thermal reaction in low-oil-conte nt shale,achieving an energy efficiency of 3.70.For medium oil content shale,a 2.0%natural gas addition,and for high oil content shale,a 4.0%addition,significantly reduces the gas compression energy required,enhancing energy efficiency to 8.11 and 13.04,respectively—representing improvements of 29.47%and 19.19%over the ATS process alone.This study evaluates the applicability of H-ATS technology across various oil shale formations,providing a new approach for the commercialization of in-situ conversion technology. 展开更多
关键词 Oil shale Autothermic pyrolysis in-situ conversion process Natural gas-assisted Energy efficiency
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Pyrite-based mixotrophic denitrification promoted nitrogen removal from actual secondary effluent in natural aerobic environments:Particle-size optimization and microbial synergism 认领 引用
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作者 Yanbo Jiang Minlong Li +3 位作者 Xiaona Zheng Song Liu Xingcan Feng Yuntao Guan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期221-230,共10页
Implementing advanced nitrogen removal in wastewater treatment plants has emerged as a critical strategy to comply with tightening global nitrogen discharge mandates.To achieve advanced nitrogen removal under low-carb... Implementing advanced nitrogen removal in wastewater treatment plants has emerged as a critical strategy to comply with tightening global nitrogen discharge mandates.To achieve advanced nitrogen removal under low-carbon treatment conditions,pyrite-based mixotrophic denitrification(PMD)demonstrates promising application prospects.However,existing research predominantly focuses on synthetic wastewater in laboratory settings,with insufficient attention to practical applications using complex real wastewater.This study investigated PMD treating actual secondary effluent(TN:16-25 mg/L)from a full-scale wastewater treatment plant under natural aerobic conditions.Through optimized pyrite particle size(1.2-2.4 mm)and carbon-to-nitrogen ratio(C/N=3:1),PMD achieved 90.8%TN removal efficiency with effluent TN<2 mg/L,meeting stringent discharge standards.Under optimized conditions,oxygen boosted S2-/Fe2+release from pyrite.The 1.2-2.4 mm particles created micro-aerobic and micro-anaerobic niches,which facilitated synergistic symbiosis between autotrophic and heterotrophic denitrifiers.This microbial collaboration endowed the system with enhanced denitrification performance and improved filtration characteristics.The dominant bacterial genera in optimal conditions were unclassified_f_Rhodocyclaceae(22.4%),unclassified_f_Comamonadaceae(16.3%),and Thauera(5.9%),while nirK-type denitrifying bacteria dominated the denitrification in this system.This research offers valuable recommendations for developing an energy-efficient and low-carbon advanced nitrogen removal process in wastewater treatment facilities. 展开更多
关键词 Pyrite particle size Natural aerobic Actual secondary effluent Advanced nitrogen removal Microbial synergism
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Plant-derived natural products improve disease:focus on gut-brain axis 认领 引用
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作者 Chen Song Wenjing Lang +2 位作者 Li Meng Wenxiang Ping Jingping Ge 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1567-1580,共14页
Dysbiosis of the gut microbiota may lead to a wide range of metabolic,neurological,intestinal and cardiovascular disorders and even to tumorigenesis.Evidence suggests that the gut-brain axis(GBA)plays a crucial role i... Dysbiosis of the gut microbiota may lead to a wide range of metabolic,neurological,intestinal and cardiovascular disorders and even to tumorigenesis.Evidence suggests that the gut-brain axis(GBA)plays a crucial role in the treatment of these diseases.Many plant-derived natural actives modulate the gut microbiota and its metabolites,gut hormones and neurotransmitters through a variety of mechanisms,and these actions contribute to the alleviation of irritable bowel syndrome,type 2 diabetes mellitus,cancer,and brain disorders.This review focuses on how natural products act through the GBA to protect the central nervous system,regulate metabolism and promote apoptosis in cancer cells.The role of gut microbiota metabolites and neurotransmitter release in modulating inflammation-related factors,promoting or reducing oxidative stress,and activating or inhibiting related signaling pathways is also discussed.This comprehensive overview of the complex GBA mechanisms deepens the understanding of how natural products can target the GBA to treat disease,providing valuable insights into the development and utilization of these natural interventions. 展开更多
关键词 Natural products Gut-brain axis Gut microbiota Disease
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Dynamic conditions and processes of three-dimensional accumulation of Sinian-Permian natural gas in Penglai gas area,central Sichuan Basin,SW China 认领 引用
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作者 LUO Bing ZHANG Benjian +8 位作者 ZHOU Gang WU Luya YAN Wei ZHANG Baoshou ZHANG Xihua ZHONG Yuan MA Kui LUO Xiaorong LI Yishu 《Petroleum Exploration and Development》 SCIE 2026年第2期327-342,共16页
Considering the complexities of gas-water relationships in the gas reservoirs,unclear natural gas distribution and difficult exploration expansion of the Sinian–Permian natural gas in the Penglai gas area of the cent... Considering the complexities of gas-water relationships in the gas reservoirs,unclear natural gas distribution and difficult exploration expansion of the Sinian–Permian natural gas in the Penglai gas area of the central Sichuan Basin,this study investigates the gas source,charging processes and enrichment patterns of gas reservoirs based on reservoir characterization,natural gas geochemical analysis,reservoir testing,well logging-seismic data interpretation,as well as basin modeling and dynamic analysis.The results are obtained in three aspects.First,four sets of highly efficient source rocks are developed beneath the salt of the Triassic Jialingjiang Formation,dominated by the Cambrian source rocks.The reservoirs exhibit strong heterogeneity,with six sets of effective reservoirs being isolated from each other yet dynamically connected.Multi-stage strike-slip fault-related fault-fracture-cavity-unconformity systems constitute the hydrocarbon migration network.Second,overpressure generated by hydrocarbon generation in the Cambrian source rocks drove bidirectional hydrocarbon expulsion from the source kitchen.Multiple sources,including cracked gas from paleo-oil reservoirs and residual hydrocarbons within source rocks,contributed to the hydrocarbon supply.The Sinian–Permian system underwent multiple dynamic hydrocarbon accumulation processes,resulting in the formation of extensive“sweet spots”within multi-layered heterogeneous reservoirs,which were subsequently modified by late-stage gas adjustments to their current form.Third,a three-dimensional accumulation model for deep marine natural gas is established,with multi-source hydrocarbon supply,three-dimensional migration,multi-stage accumulation,dynamic adjustment and lithology-controlled distribution.Large-scale reservoirs within positive structural settings,late-stage structurally stable areas,and slope structures are identified as favorable plays for gas exploration. 展开更多
关键词 Sinian Cambrian Permian natural gas dynamic condition three-dimensional accumulation Penglai gas area Sichuan Basin
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