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Clues to prognosis in anterior ischemic optic neuropathy:an optical coherence tomography angiography study 认领 引用
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作者 Maria JRodrigo Diego Fernandez-Velasco +5 位作者 Pablo Pérez-Gómez Isabel Fuertes Luis E.Pablo Manuel Subías Josep O.Casanovas-Marsal Elena Garcia-Martin 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第6期1096-1106,共11页
AIM:To investigate optic nerve vascularization in patients with anterior ischemic optic neuropathy(AION)during the first 3mo after onset,using comprehensive ophthalmic assessments combined with optical coherence tomog... AIM:To investigate optic nerve vascularization in patients with anterior ischemic optic neuropathy(AION)during the first 3mo after onset,using comprehensive ophthalmic assessments combined with optical coherence tomography(OCT)and optical coherence tomography angiography(OCT-A).METHODS:A prospective longitudinal observational study was performed with a 3-month follow-up.Clinical data recorded included age,sex,laterality of ocular involvement,AION subtype,previous history of ischemic events,cardiovascular risk factors such as high blood pressure,dyslipidemia,diabetes mellitus,smoking status,obstructive sleep apnea,and systemic treatments received.Functional,structural,and vascular examinations,including best corrected visual acuity(BCVA),visual field,OCT,and OCT-A,were performed at baseline,1,and 3mo.RESULTS:Twenty-two subjects included 12 patients with AION and 10 healthy controls were enrolled.Mean age was 63.75±8.32y in the AION group and 61.80±5.04y in the control group(P=0.365).Gender and laterality distributions were comparable.AION patients showed significantly decreased optic nerve head perfusion at baseline(P=0.024)and 1mo(P=0.033).OCT revealed early thickening and subsequent atrophy of the peripapillary retinal nerve fiber layer and macular layers.OCT-A vascular parameters correlated significantly with 1-month BCVA(r=0.800,P≤0.05)and 3-month structural outcomes(r=0.807-0.835,P≤0.05).CONCLUSION:Vascular parameters derived from OCT-A can act as predictive markers for medium-term visual and structural outcomes in patients with ischemic optic neuropathy. 展开更多
关键词 vascularization optic nerve anterior ischemic optic neuropathy optical coherence tomography angiography
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Imaging of retinal nerve fiber in non-arteritic anterior ischemic optic neuropathy at acute,sub-acute,and chronic phases:adaptive optics scanning laser ophthalmoscopy versus optical coherence tomography 认领 引用
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作者 Yi Gong Shuo Sun +3 位作者 Rong Luan Bo-Shi Liu Rong-Guo Yu Xiao-Rong Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第6期1201-1205,共5页
Dear Editor,Non-arteritic anterior ischemic optic neuropathy(NAION)is the most common acute optic neuropathy in individuals over 50 years old,characterized by a sudden,painless,monocular vision loss or variable visual... Dear Editor,Non-arteritic anterior ischemic optic neuropathy(NAION)is the most common acute optic neuropathy in individuals over 50 years old,characterized by a sudden,painless,monocular vision loss or variable visual field defect with optic disc edema[1].Although the exact pathogenesis of NAION remains uncertain,optic disc swelling and nerve compression results in axonal damage and retinal ganglion cell apoptosis[2].Retinal nerve fiber layer(RNFL)defect detection is essential for diagnosing and managing NAION.The RNFL loss could be detected and evaluated by optical coherence tomography(OCT)and various other imaging techniques[3].Nonetheless,none of these modalities have the necessary lateral resolution to visualize individual RNFL bundles,largely due to aberrations in ocular optics. 展开更多
关键词 retinal ganglion cell apoptosis retinal non arteritic anterior ischemic optic neuropathy acute optic neuropathy axonal damage nerve compression adaptive optics scanning laser ophthalmoscopy disc swelling retinal nerve fiber layer
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Juan Bi Tong Luo,a traditional Chinese medicine,ameliorates diabetic peripheral neuropathy by downregulating the MAPK/NF-κB signaling pathway 认领 引用
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作者 Wei Liu Yue Zhu +1 位作者 Wei Song Fei Huang 《Traditional Medicine Research》 2026年第3期56-64,共9页
Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k... Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN. 展开更多
关键词 Juan Bi Tong Luo diabetic peripheral neuropathy inflammation
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Amomum villosum extract alleviates diabetic neuropathy via phosphoinositide 3-kinase/AKT-mediated antioxidative and antiapoptotic effects 认领 引用
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作者 Dong-Quan Kou Ming-Jie Liu +1 位作者 Xiao-Lan Gao Fu-Rong Guo 《World Journal of Diabetes》 SCIE 2026年第3期162-174,共13页
BACKGROUND Diabetic peripheral neuropathy(DPN)affects nearly half of patients with diabetes and is projected to increase substantially as the diabetes prevalence rises globally.Current treatments remain largely sympto... BACKGROUND Diabetic peripheral neuropathy(DPN)affects nearly half of patients with diabetes and is projected to increase substantially as the diabetes prevalence rises globally.Current treatments remain largely symptomatic with limited efficacy in halting disease progression.Amomum villosum Lour.(AVL),a traditional Chinese medicinal herb with anti-inflammatory and antioxidant properties,represents a potential new therapeutic candidate for DPN management.AIM To explore the therapeutic effects of the aqueous extract of AVL on DPN in rats and its underlying molecular mechanisms.METHODS A type 1 diabetic rat model was induced by streptozotocin.Pain thresholds were assessed using paw withdrawal threshold and paw withdrawal latency.Primary dorsal root ganglion(DRG)neurons were extracted and cultured to detect indicators related to oxidative stress,inflammatory response,and apoptosis.The therapeutic effects of AVL on DPN rats were evaluated using Western blotting,quantitative PCR,enzyme-linked immunosorbent assay,reactive oxygen species(ROS)content detection,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)assay,and flow cytometry.The molecular mechanisms of AVL in inhibiting oxidative stress and apoptosis via the phosphoinositide 3-kinase(PI3K)/AKT signaling pathway were also explored.RESULTS AVL treatment significantly counteracted the elevated blood glucose and reduced body weight in diabetic rats.The mechanical and thermal pain thresholds were significantly increased,indicating AVL's analgesic effects.In the diabetes mellitus(DM)+AVL group,the expression of inflammatory cytokines[tumor necrosis factor alpha,interleukin 6(IL-6),IL-1β]and malondialdehyde content in DRG tissue were lower than those in the DM+vehicle group.However,compared with the DM+vehicle group,the glutathione level was increased in the DM+AVL group.Consistently,immunofluorescence showed that the fluorescence intensity representing ROS in primary DRG neurons was also significantly reduced compared with the DM+vehicle group.In addition,flow cytometry and TUNEL assays revealed that AVL treatment markedly decreased the apoptosis rate of DRG neurons,as evidenced by downregulated caspase-3 and B-cell lymphoma 2(Bcl-2)-associated X protein expression and upregulated Bcl-2 expression,indicating that AVL also inhibits DRG neuronal apoptosis.Further mechanistic studies demonstrated that AVL treatment activated the PI3K/AKT signaling pathway in DRG neurons.However,intervention with the PI3K inhibitor LY294002 significantly reversed the therapeutic effects of AVL on DNP rats.Mechanistically,AVL activated the PI3K/AKT signaling pathway,suppressing oxidative stress and apoptosis in the DRG tissue of DNP rats.CONCLUSION AVL alleviates DNP in rats by activating the PI3K/AKT signaling pathway,inhibiting oxidative stress and apoptosis and reducing inflammatory responses.This study provides strong experimental evidence for the application of AVL in DNP treatment and offers new ideas and directions for the development of DNP treatments based on natural medicines. 展开更多
关键词 Amomum villosum Lour. Diabetic peripheral neuropathy phosphoinositide 3-kinase/AKT Oxidative stress Apoptosis
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Corneal neuropathy:An overlooked biomarker for dry eye in type 2 diabetes 认领 引用
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作者 Marco Zeppieri Matteo Capobianco +3 位作者 Federico Visalli Marieme Khouyyi Caterina Gagliano Francesco Cappellani 《World Journal of Diabetes》 SCIE 2026年第2期8-13,共6页
The article by Han and associates highlights a frequently neglected consequence of type 2 diabetes mellitus(T2D):Dry eye disease associated with corneal neuropathy.Their findings indicate that patients with T2D exacer... The article by Han and associates highlights a frequently neglected consequence of type 2 diabetes mellitus(T2D):Dry eye disease associated with corneal neuropathy.Their findings indicate that patients with T2D exacerbated by dry eye disease exhibit substantial decreases in corneal nerve density,length,and count,accompanied by heightened tortuosity,all of which correlate strongly with clinical severity scores.This study contributes to the expanding literature that regards ocular surface disease not only as a secondary effect of systemic illness but also as a direct indication of neurovascular and metabolic impairment.Clinically,these findings underscore the importance of regularly evaluating dry eye in patients with T2D,extending beyond diabetic retinopathy,and incorporating ocular surface assessments into comprehensive diabetes management.This study demonstrates that the diabetic eye exhibits both tear film instability and corneal neurodegeneration,thereby expanding our understanding of diabetic eye disease and emphasizing the need for multidisciplinary care to preserve vision and improve quality of life. 展开更多
关键词 Type 2 diabetes Corneal neuropathy Dry eye syndrome Ocular surface disease biomarkers Inflammatory biomarkers Oxidative stress Precision medicine
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Mitophagy Activation by N-Acetylcysteine Protects against Mic60 Deficiency-Induced Auditory Neuropathy 认领 引用 被引量：1
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作者 Yilin Sun Chunying Liu +9 位作者 Yakun Liang An Lv Wang Nie Shuyue Bao Xiaoyi Li Jing Zhou Weimin Tong Yong Tao Xueling Wang Tingting Dong 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第3期630-648,共19页
Auditory neuropathy(AN)is a sensorineural hearing loss that impairs speech perception,but its mechanisms and treatments remain limited.Mic60,essential for the mitochondrial contact site and cristae organizing system,i... Auditory neuropathy(AN)is a sensorineural hearing loss that impairs speech perception,but its mechanisms and treatments remain limited.Mic60,essential for the mitochondrial contact site and cristae organizing system,is linked to neurological disorders,yet its role in the auditory system remains unclear.We demonstrate that Mic60+/-mice develop progressive hearing loss from 6 months of age,with reduced auditory brainstem response amplitudes despite preserved outer hair cell function,consistent with AN.Mitochondrial abnormalities in spiral ganglion neurons(SGNs)emerge by 3 months,followed by mitochondrial loss and SGN degeneration,indicating progressive auditory neuron dysfunction.In vitro,Mic60 deficiency disrupts mitochondrial respiration,reversible by N-acetylcysteine(NAC).NAC treatment preserves mitochondrial integrity and rescues hearing by enhancing mitophagy.Our findings establish Mic60+/-mice as an AN animal model,highlight the role of Mic60 in the mitochondria of primary auditory neurons,and identify NAC as a potential AN treatment. 展开更多
关键词 Mic60 Mitochondria Auditory neuropathy Mitophagy Antioxidant N-acetylcysteine
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Optic neuropathy arising from the synergy between YARS2 and mitochondrial COX1 mutations 认领 引用
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作者 Huiying Li Cheng Ai +5 位作者 Xiaofen Jin Jing Wang Jun Yu Yinglong Gao Douglas CWallace Min-Xin Guan 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第7期1266-1282,共17页
Leber hereditary optic neuropathy(LHON)is a paradigm for mitochondrial retinopathy.Here,we investigate the mechanism underlying the interaction between nuclear modifier and mtDNA mutation(s)that manifests optic neurop... Leber hereditary optic neuropathy(LHON)is a paradigm for mitochondrial retinopathy.Here,we investigate the mechanism underlying the interaction between nuclear modifier and mtDNA mutation(s)that manifests optic neuropathy in vivo to develop an effective therapeutic approach for this disease,using mouse models bearing LHON-linked Yars2G186V or COIV421A mutation alone and double mutations.Yars2G186V alters mitochondrial translation and assembly and activities of complex Ⅰ,Ⅲ,and Ⅳ,while COIV421A reduces complex Ⅳ activity.However,a single Yars2G186V orCOIV421A mutation causes mild declines in ATP production and yields relatively mild degeneration of retinal ganglion cells(RGCs).Notably,the synergy between COIV421A and Yars2G186V mutations aggravates mitochondrial dysfunction and oxidative stress.Interestingly,COIV421A mainly promotes apoptosis,and Yars2G186V contributes to ferroptosis.The combination of two mutations accelerates the degeneration of RGCs and photoreceptors.Strikingly,AAV-mediated Yars2 expression in the mouse retina carrying both Yars2G186V and COIV421A mutations corrects the defective translation and ferroptosis arising from the Yars2G186V mutation and remarkably improves mitochondrial function and causes morphologic and functional recovery of RGCs and photoreceptors.These findings provide mechanistic insights into the pathophysiology of LHON arising from nuclear modifiers and mtDNA mutation(s)and potential therapeutic strategies for LHON and other mitochondrial diseases. 展开更多
关键词 Optic neuropathy Mitochondrial DNA mutation Mitochondrial tyrosyl-tRNA synthetase Oxidative phosphorylation Ferroptosis Apoptosis Gene therapy
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Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy-mechanisms,challenges,and emerging therapeutics 认领 引用
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作者 Nayab Khalid Nazlahshaniza Shafin +2 位作者 Idris Long Hidani Hasim Che Aishah Nazariah Ismail 《World Journal of Diabetes》 SCIE 2026年第1期33-47,共15页
A notable number of patients with diabetes suffer from painful diabetic neuropathy(PDN),which is a debilitating complication of diabetes mellitus.Prolonged hyperglycaemia and metabolic dysregulation lead to PDN,a cond... A notable number of patients with diabetes suffer from painful diabetic neuropathy(PDN),which is a debilitating complication of diabetes mellitus.Prolonged hyperglycaemia and metabolic dysregulation lead to PDN,a condition characterised by chronic pain,sensory dysfunction,and reduced quality of life.Although various treatment options are available,clinical management is challenging due to the complex and multifactorial nature of PDN pathophysiology.N-methyl-D-aspartate receptors(NMDARs),particularly the NR2B subtype(NMDAR-2B),have emerged as a key player in the pathophysiology of chronic pain states,including PDN.This review highlights the mechanistic NMDAR-2B involvement in the pathophysiology of PDN,focusing on its upregulation role in pain-processing regions,interaction with inflammatory mediators,glia-derived mediators,and oxidative stress mechanisms.Advancements in targeting NMDAR-2B as a mechanistically driven approach to PDN management also offer potential in enhancing the therapeutic efficacy of NMDAR-2B.Consequently,this review provides a novel perspective on understanding the role of NMDAR-2B in PDN for the future development of effective treatment strategies for managing the condition. 展开更多
关键词 Painful diabetic neuropathy N-methyl-D-aspartate receptor 2B Chronic pain Oxidative stress Inflammation Nociception Glia
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Innovative strategies for diabetic peripheral neuropathy:From clinical management to emerging bioengineering solutions 认领 引用
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作者 Zhi He Jie Diao +1 位作者 Frederick G.Hamel Bin Duan 《Bioactive Materials》 SCIE CSCD 2026年第7期312-338,共27页
Diabetic peripheral neuropathy(DPN)is a common,incurable complication of diabetes that causes sensory loss,pain,and motor problems.Conventional treatments like blood glucose management,pain relief,and neuro-protective... Diabetic peripheral neuropathy(DPN)is a common,incurable complication of diabetes that causes sensory loss,pain,and motor problems.Conventional treatments like blood glucose management,pain relief,and neuro-protective drugs have limited success and do not prevent disease progression.Advances in neurobiology,regenerative medicine,and bioengineering have led to novel therapies that target underlying mechanisms and promote regeneration.Monitoring and evaluating the onset and progression of DPN are essential for effective clinical management.Given rapid advances in understanding DPN and developing new treatments,a compre-hensive review that covers clinical progress,molecular pathology techniques,and emerging bioengineering strategies is both timely and essential.This review addresses:(1)DPN pathophysiology;(2)drug therapies from clinical trials since 2020;(3)animal models used in DPN research;(4)progress and challenges in biomaterialbased drug delivery systems;(5)developments and limitations of microfluidic platforms for DPN modeling;and(6)bioengineered devices used for DPN diagnosis and monitoring.Integrating clinical insights,molecular techniques,and bioengineering innovations seeks to create a forward-looking framework for next-generation DPN treatment and management. 展开更多
关键词 Diabetic peripheral neuropathy Drug therapies Animal models Biomaterial-based drug delivery systems Microfluidic platforms Bioengineered devices
Association of serum bile acid profiles with the risk of gastrointestinal autonomic neuropathy in patients with type 2 diabetes mellitus 认领 引用
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作者 Ke-Ying Zhu Si-Jing Wang +6 位作者 Jie Li Pan-Pan Ma Su-Su Feng Lin Guo Yi-Bing Lu Li Dong Da-Fa Ding 《World Journal of Diabetes》 SCIE 2026年第2期88-103,共16页
BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common yet underrecognized manifestation of diabetic neuropathy.However,the clinical correlations and associated alterations of serum bile acid(BA)me... BACKGROUND Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common yet underrecognized manifestation of diabetic neuropathy.However,the clinical correlations and associated alterations of serum bile acid(BA)metabolism with DGAN remain unclear.AIM To identify potential metabolite biomarkers capable of identifying DGAN among patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional study included 26 patients with clinically defined DGAN and 69 patients with uncomplicated T2DM.Fifteen individual BAs were quantified in fasting serum using liquid chromatography-tandem mass spectrometry.Gastrointestinal symptoms were scored using the Gastrointestinal Symptom Rating Scale.Spearman’s correlation,multivariable logistic regression,receiver operating characteristic,and decision curve analyses were used to explore the associations and build a predictive nomogram.RESULTS Orthogonal partial least squares discriminant analysis of serum BAs revealed clear separation between the T2DM and DGAN groups,identifying taurolithocholic acid(TLCA)as the key discriminator(variable importance in projection>1,fold change<0.5).Univariate logistic regression identified age,body mass index,hemoglobin,fasting/2-h C-peptide,albumin,and TLCA levels as protective factors and the urinary albumin-to-creatinine ratio as a risk factor.After multivariate adjustment age,fasting C-peptide levels,and TLCA levels remained independently associated with DGAN.Receiver operating characteristic analysis yielded areas under the curve of 0.651,0.760,and 0.678 for age,fasting C-peptide,and TLCA,respectively,and the three variables collectively had an area under the curve of 0.970(95%confidence interval:0.937-1.000).Decision curve analysis confirmed the clinical net benefit across threshold probabilities of 9%-68%.The derived nomogram displayed excellent calibration and net clinical benefits for the model.CONCLUSION These findings highlighted the association between altered BA profiles and DGAN in patients with T2DM.Combining BA profiling with conventional clinical data could facilitate the early identification of DGAN and offer new insights into early screening and BA-targeted interventions.While these findings offer valuable insights,they should nevertheless be viewed as hypothesis-generating and require further validation in larger,multicenter cohorts. 展开更多
关键词 Type 2 diabetes mellitus Diabetic gastrointestinal autonomic neuropathy Serum bile acids profiles Gastrointestinal Symptom Rating Scale
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Drosophila view on glia in peripheral sensory neuropathy 认领 引用
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作者 Steffen Kautzmann Christian Klämbt 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2353-2354,共2页
Peripheral sensory neurons perceive external signals and convey signals to the central nervous system(CNS).Information transmission occurs via often extremely long axons and timely reactions of the animal require a fa... Peripheral sensory neurons perceive external signals and convey signals to the central nervous system(CNS).Information transmission occurs via often extremely long axons and timely reactions of the animal require a fast conductance velocity.This not only depends on axonal diameter and insulation by glial processes,but it requires the structural integrity of the axon. 展开更多
关键词 peripheral sensory neurons central nervous system cns information Drosophila peripheral sensory neuropathy glial processesbut conductance velocitythis structural integrity glia
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MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy:A systematic review 认领 引用
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作者 Tsampika-Vasileia Kalamara Dimitrios A Andreikos +5 位作者 Konstantinos Dodos Elisavet Georgiou George Fotakopoulos Nikolaos Foroglou Dorothea Kapoukranidou Vasiliki E Georgakopoulou 《World Journal of Clinical Oncology》 2026年第4期176-188,共13页
BACKGROUND Chemotherapy-induced peripheral neuropathy(CIPN)is a frequent,dose-limiting toxicity of neurotoxic antineoplastic agents,yet clinicians lack minimally invasive biomarkers to predict susceptibility,monitor n... BACKGROUND Chemotherapy-induced peripheral neuropathy(CIPN)is a frequent,dose-limiting toxicity of neurotoxic antineoplastic agents,yet clinicians lack minimally invasive biomarkers to predict susceptibility,monitor neuroaxonal injury and stratify longterm risk.Circulating microRNAs(miRNAs)are attractive candidates because they integrate stress and injury responses and can be robustly quantified in blood.AIM To systematically review human studies evaluating miRNAs as diagnostic or prognostic biomarkers of CIPN.METHODS Following PRISMA guidelines,we searched PubMed,Cochrane Library,Scopus and conference proceedings from inception to August 2025 for observational studies including patients with malignant disease treated with neurotoxic chemotherapy,comparing those who developed CIPN with those who did not,and reporting differences in miRNA expression.Data on clinical setting,chemotherapy type,CIPN assessment,miRNA source and quantification methods,and direction of expression changes were extracted.Owing to clinical and methodological heterogeneity,we performed a qualitative synthesis.RESULTS Five studies(three prospective cohorts,one case-control,one retrospective)comprising 304 patients(137 with CIPN)were included.Malignancies included breast,gastric and colorectal cancer and multiple myeloma;neurotoxic regimens involved oxaliplatin,paclitaxel and bortezomib.Across studies,30 unique miRNAs were investigated.In multiple myeloma,miR-191-5p,miR-23a-3p,miR-24-3p,miR-92 and miR-22-3p were upregulated in patients with CIPN,with miR-22-3p showing one of the largest expression differences.In oxaliplatin-treated gastric and colorectal cancer,hsa-miR-378f,hsa-miR-885-5p,hsa-miR-200c-3p,hsa-miR-4666a-3p and miR-3184-5p were downregulated and some correlated with CIPN severity,whereas 21 miRNAs showed no significant differences and paclitaxel-based studies reported no consistent miRNA-CIPN associations.CONCLUSION Current human data support the biological plausibility of circulating miRNAs-particularly miR-22-3p,hsa-miR-378f and miR-3184-5p-as candidate diagnostic and prognostic biomarkers for CIPN,but the evidence base remains small and heterogeneous.Standardized,adequately powered,longitudinal studies with harmonized CIPN phenotyping,assay platforms and reporting of effect sizes and predictive accuracy are required before miRNA-based tests can be translated into routine risk stratification and monitoring of CIPN. 展开更多
关键词 Chemotherapy-induced peripheral neuropathy MicroRNA Biomarker Neurotoxicity Liquid biopsy
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Gut microbiota:Unseen conductor of polyherbal efficacy in diabetic neuropathy 认领 引用
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作者 Si Chen Yu-Xiang Liu +3 位作者 Zhi-Bo Zhao Shu-Qin Tang Jun-Hu Li Xiao-Shuang Zhou 《World Journal of Diabetes》 SCIE 2026年第6期52-61,共10页
The recent study provides compelling evidence for the neuroprotective effects of a polyherbal extract(PHE)in a rat model of diabetic neuropathy(DN).While the authors demonstrate significant improvements in metabolic,o... The recent study provides compelling evidence for the neuroprotective effects of a polyherbal extract(PHE)in a rat model of diabetic neuropathy(DN).While the authors demonstrate significant improvements in metabolic,oxidative,and inflammatory parameters,this review posits that these downstream effects are likely orchestrated by a crucial upstream mechanism:The modulation of the gut microbiota.We argue that DN is intrinsically linked to gut dysbiosis,which promotes a“leaky gut”,systemic inflammation,and a deficit in neuroprotective microbial metabolites like short-chain fatty acids.The complex,poorly absorbed components of the PHE likely act as prebiotics,restoring microbial homeostasis.This single action can mechanistically explain the observed systemic benefits from reduced inflammation to improved neurotrophic support.Recognizing the gut microbiota as the central mediator bridges the multi-component nature of traditional herbal medicine with the complex,multi-system pathology of DN,paving the way for novel,microbiome-targeted therapeutic strategies. 展开更多
关键词 Diabetic neuropathy Gut microbiota Polyherbal formulation Prebiotics Short-chain fatty acids Inflammation Traditional medicine
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甲状腺功能正常的T2DM患者血清甲状腺激素、骨代谢指标对DPN的诊断价值 认领 引用
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作者 张丹 欧红芹 +4 位作者 姚晓玲 吴冬会 王科 王树 郑岚 《检验医学与临床》 CAS 2026年第6期803-808,共6页
目的探讨甲状腺功能正常的2型糖尿病(T2DM)患者血清甲状腺激素、骨代谢指标对糖尿病周围神经病变(DPN)的诊断价值。方法纳入2023年4月至2025年5月该院内分泌科收治的116例T2DM患者作为研究对象。根据是否合并DPN分为DPN组(46例)和非DPN... 目的探讨甲状腺功能正常的2型糖尿病(T2DM)患者血清甲状腺激素、骨代谢指标对糖尿病周围神经病变(DPN)的诊断价值。方法纳入2023年4月至2025年5月该院内分泌科收治的116例T2DM患者作为研究对象。根据是否合并DPN分为DPN组(46例)和非DPN组(70例)。记录患者人口学特征及基线资料[性别、年龄、T2DM病程、体质量指数(BMI)、是否合并糖尿病其他慢性并发症、高血压、高脂血症],检测血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、25-羟维生素D[25(OH)D]、骨钙素N端中分子片段(N-MID)、总Ⅰ型胶原氨基端延长肽(TP1NP)、β-胶原特殊序列(β-CTX)、甲状旁腺激素(PTH)水平。对比2组基线资料及实验室指标差异,采用多因素Logistic回归分析T2DM患者发生DPN的独立危险因素,绘制受试者工作特征(ROC)曲线,分析FT3、25(OH)D、N-MID单独及联合检测对DPN的诊断效能。结果与非DPN组相比,DPN组年龄较大(P<0.05),病程更长(P<0.05),且FT3、25(OH)D、NMID、β-CTX水平均显著降低(P<0.05)。多因素Logistic回归分析结果显示,T2DM病程长,FT3、25(OH)D和N-MID水平降低是发生DPN的独立危险因素(P<0.05)。ROC曲线分析结果显示,FT3、25(OH)D和NMID单独及联合检测诊断DPN的曲线下面积(AUC)分别为0.644、0.780、0.659、0.852,联合检测的AUC显著高于单项指标(Z3项联合-FT3=3.815、P3项联合-FT3<0.001,Z3项联合-25(OHD)=2.309、P3项联合-25(OHD)=0.021,Z3项联合-N-MID=3.509、P3项联合-N-MID<0.001)。结论甲状腺功能正常的T2DM患者血清FT3、25(OH)D、N-MID水平降低,且与DPN的发生密切相关,3项联合检测可以有效诊断T2DM患者DPN的发生。 展开更多
关键词 糖尿病周围神经病变 25-羟维生素D 游离三碘甲状腺原氨酸 骨钙素N端中分子片段 总Ⅰ型胶原氨基端延长肽 β-胶原特殊序列
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Comprehensive review on diabetic foot ulcers and neuropathy: Treatment, prevention and management 认领 引用 被引量：8
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作者 Kehkashan Parveen Malik Asif Hussain +2 位作者 Sadaf Anwar Halima Mustafa Elagib Mohd Adnan Kausar 《World Journal of Diabetes》 SCIE 2025年第3期14-29,共16页
Diabetic foot(DF)is a major public health concern.As evident from numerous previous studies,supervision of DF ulcer(DFU)is crucial,and a specific quality check-up is needed.Patients should be educated about glycaemic ... Diabetic foot(DF)is a major public health concern.As evident from numerous previous studies,supervision of DF ulcer(DFU)is crucial,and a specific quality check-up is needed.Patients should be educated about glycaemic management,DFUs,foot lesions,proper care for injuries,diet,and surgery.Certain reasonably priced treatments,such as hyperbaric oxygen and vacuum-assisted closure therapy,are also available for DFUs,along with modern wound care products and techniques.Nonetheless,DF care(cleaning,applying antimicrobial cream when wounded,and foot reflexology),blood glucose monitoring to control diabetes,and monthly or quarterly examinations in individuals with diabetes are effective in managing DFUs.Between 50%and 80%of DF infections are preventable.Regardless of the intensity of the lesion,it needs to be treated carefully and checked daily during infection.Tissue regeneration can be aided by cleaning,dressing,and application of topical medicines.The choice of shoes is also important because it affects blood circulation and nerve impulses.In general,regular check-ups,monitoring of the patient’s condition,measuring blood glucose levels,and providing frequent guidance regarding DFU care are crucial.Finally,this important clinical problem requires involvement of multiple professionals to properly manage it. 展开更多
关键词 Diabetic foot ulcers Diabetic neuropathy Diabetes mellitus Peripheral neuropathy Charcot neuroarthropathy
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Diabetic gastrointestinal autonomic neuropathy:Integrating neuronal degeneration and gut microbial dysbiosis 认领 引用 被引量：3
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作者 Mei-Xia Zhou Yu Zhao +3 位作者 Chen-Ling Chu Tapas Ranjan Behera Quan-Quan Shen Yu-Bo Xing 《World Journal of Diabetes》 SCIE 2025年第9期84-94,共11页
Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common and debilitating complication of diabetes,characterized by autonomic dysfunction in the gastrointestinal system.The complex pathophysiology of DGAN invol... Diabetic gastrointestinal autonomic neuropathy(DGAN)is a common and debilitating complication of diabetes,characterized by autonomic dysfunction in the gastrointestinal system.The complex pathophysiology of DGAN involves neuronal injury that is intrinsically linked to gut dysbiosis.Multiple factors,including hyperglycemia,oxidative stress,and inflammation,significantly contribute to neuronal damage,manifesting as symptoms such as delayed gastric emptying,diarrhea,and constipation.Recent studies have demonstrated that patients with diabetes experience substantial alterations in gut microbiota composition,potentially exacerbating gastrointestinal symptoms.Microbial metabolites may modulate neurotransmitter synthesis and release,directly affecting autonomic nerve function,while dysbiosis amplifies oxidative stress and inflammation,further compromising the enteric nervous system and worsening DGAN.Advances in multi-omics technologies now provide deeper insights into molecular mechanisms of DGAN and its interactions with microbiota.Early diagnosis leveraging biomarkers,gut microbiota analysis,and advanced imaging promises more effective interventions.Emerging therapeutic strategies targeting oxidative stress,inflammation,and gut microbiota represent promising approaches for managing DGAN.Future research should focus on large-scale,multi-ethnic studies and therapies targeting specific microbial metabolites to refine diagnosis and treatment approaches. 展开更多
关键词 Diabetic neuropathy Gastrointestinal Enteric neuropathy Diabetes Neuropathy Gut microbiota Gut dysbiosis
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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects 认领 引用 被引量：8
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作者 Rahul Mittal Keelin McKenna +4 位作者 Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第8期2218-2230,共13页
Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this condition.Diabetic peripheral neuropathy,a common complication of dia... Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this condition.Diabetic peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and feet.The aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this domain.The investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord stimulation.This systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral neuropathy.Understanding the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic treatments.Through these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy. 展开更多
关键词 diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management
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Establishment of a novel alloxan-induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG+VEP 认领 引用 被引量：2
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作者 Xinlu Li Xiaojing Dong +7 位作者 Defei Feng Han Hu Bai Li Zhongjian Liu Wei He Chenchen Huang Zhizhou Shi Yan Mei 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第9期1552-1566,共15页
Background:Diabetic retinal neuropathy(DRN)leads to significant visual impairment;however,no existing animal model fully replicates its neural alterations,and inconsistent induction protocols with high mortality rates... Background:Diabetic retinal neuropathy(DRN)leads to significant visual impairment;however,no existing animal model fully replicates its neural alterations,and inconsistent induction protocols with high mortality rates hinder long-term investigations.Methods:Adult male rabbits were randomly assigned to four experimental groups,each receiving a single intravenous injection of varying doses of alloxan and one control group.The safety and efficacy of alloxan in inducing diabetes were evaluated to determine the optimal dose.At 9 weeks following injection with alloxan,retinal function was assessed using full-field electroretinography(ERG)and visual evoked potentials(VEPs).Retinal structure was examined in rabbits using spectral-domain optical coherence tomography(SD-OCT),Optos ultra-widefield(Optos UWF)false-color imaging,and widefield fundus fluorescein angiography(WF-FFA).Results:Rabbits in the 80 mg/kg alloxan group exhibited fewer complications,lower mortality,and a higher model success rate compared to other groups.At 9 weeks post-injection,these rabbits demonstrated significantly elevated hemoglobin A1c and total cholesterol(p<0.05)relative to controls.ERG revealed statistically significant reductions in oscillatory potential and b-wave amplitudes(p<0.05),while VEP indicated decreased P2 amplitude(p<0.001)and prolonged P2 latency(p<0.05).SD-OCT,Optos UWF imaging,and WF-FFA demonstrated no significant changes in vascular abnormalities.Additionally,Hematoxylin and Eosin staining revealed retinal swelling(p<0.05),and immunofluorescence confirmed glial activation and neuronal loss.Conclusions:A single intravenous injection of 80 mg/kg alloxan effectively and safely induced DRN in rabbits,resulting in neural retina damage,thereby establishing this model as an ideal model for DRN research. 展开更多
关键词 alloxan diabetic retinal neuropathy ERG+ops rabbit VEP
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Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress 认领 引用 被引量：1
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作者 Chong-Xi Yuan Xuan Wang +3 位作者 Yun Liu Tian-Cheng Xu Zhi Yu Bin Xu 《World Journal of Diabetes》 SCIE 2025年第2期133-150,共18页
BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent i... BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent information regulator type 2 homolog-1(SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator-1α(PGC-1α)axis present new opportunities for the treatment of type 2 diabetic peripheral neuropathy(T2DPN),potentially breaking this harmful cycle.AIM To validate the effectiveness of electroacupuncture(EA)in the treatment of T2DPN and investigate its potential mechanism based on the SIRT1/PGC-1αaxis.METHODS The effects of EA were evaluated through assessments of metabolic changes,morphological observations,and functional examinations of the sciatic nerve,along with measurements of inflammation and oxidative stress.Proteins related to the SIRT1/PGC-1αaxis,involved in the regulation of mitochondrial biogenesis and antioxidative stress,were detected in the sciatic nerve using Western blotting to explain the underlying mechanism.A counterevidence group was created by injecting a SIRT1 inhibitor during EA intervention to support the hypothesis.RESULTS In addition to diabetes-related metabolic changes,T2DPN rats showed significant reductions in pain threshold after 9 weeks,suggesting abnormal peripheral nerve function.EA treatment partially restored metabolic control and reduced nerve damage in T2DPN rats.The SIRT1/PGC-1αaxis,which was downregulated in the model group,was upregulated by EA intervention.The endogenous antioxidant system related to the SIRT1/PGC-1αaxis,previously inhibited in diabetic rats,was reactivated.A similar trend was observed in inflammatory markers.When SIRT1 was inhibited in diabetic rats,these beneficial effects were abolished.CONCLUSION EA can alleviate the symptoms of T2DNP in experimental rats,and its effects may be related to the mitochondrial biogenesis and endogenous antioxidant system mediated by the SIRT1/PGC-1αaxis. 展开更多
关键词 Electroacupuncture Type 2 diabetic peripheral neuropathy Silent matching type information regulation 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1αaxis Mitochondria biogenesis Oxidative stress
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A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates 认领 引用
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作者 Zhi‑Qiang Xiao Xiu Han +9 位作者 Xin Ren Zeng‑Qiang Wang Si‑Qi Chen Qiao‑Feng Zhu Hai‑Yang Cheng Yin‑Tian Li Dan Liang Xuan‑Wei Liang Ying Xu Hui Yang 《Neuroscience Bulletin》 SCIE CAS CSCD 2025年第5期911-916,共6页
Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve ... Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve transplantation result in substantial and irreversible visual loss in patients with TON. 展开更多
关键词 traumatic optic neuropathy non human primates vision threatening condition anterior orbital approach optic nerve transplantation optic neuropathy ton nerve transplantation optic nerve
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