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Efficacy of nitroglycerin vs labetalol in hypertensive emergency among patients with a history of coronary artery disease 认领 引用 被引量：1
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作者 Ahmed Jamal Chaudhary Wasim Akbar Bhat +6 位作者 Affan Ul Haq Haroon Ur Rashid Irum Dad Khan Mah Noor Dad Khan Hafiz Muhammad Mubeen Nawaz Sameer Ali Muhammad Hamza Tariq 《World Journal of Cardiology》 2026年第2期72-80,共9页
BACKGROUND Hypertensive emergencies,characterized by severe blood pressure elevation(>180/120 mmHg)with end-organ damage,pose significant risks in patients with coronary artery disease(CAD),where rapid yet safe red... BACKGROUND Hypertensive emergencies,characterized by severe blood pressure elevation(>180/120 mmHg)with end-organ damage,pose significant risks in patients with coronary artery disease(CAD),where rapid yet safe reduction is crucial to prevent ischemia and complications.Nitroglycerin and labetalol are common intravenous agents,but comparative data in CAD are limited.AIM To compare efficacy and safety of nitroglycerin vs labetalol in hypertensive emergencies among CAD patients,assessing blood pressure control,reductions,adverse events,outcomes,and utilization.METHODS Retrospective cohort of 563 CAD patients with hypertensive emergency(2018-2024)receiving IV nitroglycerin(n=282)or labetalol(n=281).Primary:Time to target blood pressure[systolic blood pressure(SBP)<160 mmHg,diastolic blood pressure<100 mmHg].Secondary:Blood pressure reductions,major adverse cardiovascular event,safety,utilization.Analyzed via t-tests,χ2,multivariable logistic regression adjusting for age,gender,myocardial infarction/heart failure history,diabetes,baseline SBP,chest pain.RESULTS Baseline characteristics were balanced.Labetalol achieved target blood pressure faster(25.14±4.92 minutes vs 30.38±5.16 minutes;P<0.0001),but nitroglycerin yielded greater SBP(50.78±9.45 mmHg vs 45.20±10.46 mmHg;P<0.0001)and diastolic blood pressure reductions(29.86±8.63 mmHg vs 28.02±7.74 mmHg;P=0.0079).Nitroglycerin showed trends toward lower major adverse cardiovascular event[adjusted odds ratio(AOR):0.72;95%confidence interval(CI):0.42-1.24],reduced bradycardia(AOR:0.14;95%CI:0.05-0.38),shorter intensive care unit(2.99±1.04 days vs 3.54±1.02 days;P<0.0001)and hospital stays(6.92±1.93 days vs 7.99±2.06 days;P<0.0001),lower 30-day readmissions(AOR:0.49;95%CI:0.27-0.88),and smaller biomarker increases(delta troponin:0.10±0.05 ng/mL vs 0.21±0.10 ng/mL;P<0.0001).CONCLUSION While labetalol offers faster blood pressure control,nitroglycerin is associated with greater reductions,fewer adverse events like bradycardia,and improved utilization(shorter stays,fewer readmissions)in CAD-associated hypertensive emergencies,supporting its use in ischemic contexts. 展开更多
关键词 Hypertensive emergency Coronary artery disease Nitroglycerin Labetalol Blood pressure control Cardiovascular outcomes
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A self-sensing HTPB liner for non-destructive monitoring nitroglycerin(NG)migration at the interface between double base propellant and the HTPB liner 认领 引用
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作者 Jie Wang Bo Liu +4 位作者 Yanchun Li Mengqi Chen Qian Guo Dongming Song Aifeng Jiang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第8期166-175,共10页
During the storage of composite propellants, the migration of plasticizers and other unbonded additives at the interfaces of liner adhesives has garnered significant attention in understanding liner failure mechanisms... During the storage of composite propellants, the migration of plasticizers and other unbonded additives at the interfaces of liner adhesives has garnered significant attention in understanding liner failure mechanisms, aging processes, and safety performance. However, there is currently no non-destructive and quantitative detection method for migration of plasticizers in propellant liner. In this study, we developed a HTPB sensing liner by incorporating conductive fillers-namely carbon black(CB), carbon nanotubes(CNTs), and graphene nanoplatelets(GNP)-into the HTPB matrix. The synergistic interaction between CNTs and GNP facilitates the formation of a tunneling conductive network that imparts electrical conductivity to the HTPB liner. To elucidate the functional relationship between conductivity and nitroglycerin(NG) migration, we applied the HTPB sensing liner onto double base propellant surfaces and measured both the conductivity of the sensing layer and NG migration during a 71°C accelerated aging experiment. The results shows that when CNTs/GNP content reaches 3wt%, there is an exponential correlation between conductivity and NG migration with a fitting degree of 0.9652;the average response sensitivity of ΔR/R0 relative to NG migration is calculated as 41.69, with an average deviation of merely5.67% between NG migrations derived from conductivity fittings compared to those obtained via TGA testing results. Overall, this sensing liner exhibits excellent capabilities for detecting NG migration nondestructively and quantitatively while offering a novel approach for assessing interfacial component migrations as well as debonding defects in propellants-a promising avenue for future self-monitoring strategies regarding propellant integrity. 展开更多
关键词 Sensing liner Electrical conductivity Nitroglycerine migration Non-destructive detection
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Preventive Effects of Nitroglycerine on Glucocorticoid-induced Osteoporosis in Growing Rats 认领 引用 被引量：1
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作者 李裕明 李永国 杨卫红 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2007年第5期528-531,共4页
The preventive effects of nitroglycerine （NG） on glucocorticoid-induced osteoporosis in growing rats were studied. Three-month-old female Wistar rats were randomly divided into control group （CON）, dexamethasone g... The preventive effects of nitroglycerine （NG） on glucocorticoid-induced osteoporosis in growing rats were studied. Three-month-old female Wistar rats were randomly divided into control group （CON）, dexamethasone group （DXM）, DXM plus a low dose NG group （NG-L）, DXM plus a middle dose NG group （NG-M） and DXM plus a high dose NG group （NG-H）, 8 rats in each group. The rat model of osteoporosis was developed by intramuscular injection of dexamethasone twice a week. NG 0.2, 0.4 and 1.0 mg/kg was administered by oral gavages to the treatment groups every day for 12 weeks. Rats in CON group and DXM group were treated with normal saline of the same amount. After the treatment, the bone mineral density （BMD） and bone metabolism-associated biochemical markers were determined. Compared with CON group, BMD of lumbar spine and femur in DXM group was decreased significantly （P〈0.05 and P〈0.01 respectively）, blood BGP levels and NO levels reduced （both P〈0.01）, and TRAP level increased （P〈0.05）. As compared with DXM group, BMD, serum BGP and NO were increased, and TRAP decreased in NG-L group and NG-M group, but had no significant difference in comparison to CON group. All the markers other than serum NO and TRAP levels had no significant difference between NG-H group and DXM group. It was concluded that low or middle doses of NG could prevent glucocorticoid-induced bone loss in growing rats, but high dose of NG could not. Supplement with NO donor could be considered as a preventive treatment for glucocorticoid-induced osteoporosis in a developing skeleton. 展开更多
关键词 glucocorticoid-induced osteoporosis nitroglycerin nitric oxide nitric oxide donor
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Transcriptome-wide identification of differentially expressed genes and long non-coding RNAs in nitroglycerin-tolerant rat aorta 认领 引用
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作者 Chunya Cao Kai He +3 位作者 Zhenhua Zeng Jianxin Liu Wei Cai Weihua Wu 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2021年第9期725-735,共11页
Tolerance to nitroglycerin(GTN)greatly limits its long-time application,and the underlying mechanism remains largely unexplored.In the present study,we aimed to investigate the comprehensive changes in the transcripto... Tolerance to nitroglycerin(GTN)greatly limits its long-time application,and the underlying mechanism remains largely unexplored.In the present study,we aimed to investigate the comprehensive changes in the transcriptome of rat aorta tolerant to GTN by analyzing lncRNA expression.We employed the RNA sequencing(RNA-seq)technique to identify mRNAs and lncRNAs.Ingenuity pathway analysis(IPA)was used for pathway and functional analysis.RT-qPCR was used to validate the RNA-seq results.We identified 22788 genes(reads per kilobase million[RPKM]>0.1,14720 protein-coding genes and 4408 lncRNAs),including 115 differentially expressed(DE)mRNAs(65 up-regulated and 50 down-regulated)and 104 DE lncRNAs(56 up-regulated and 48 down-regulated),in GTN-tolerant aortas.IPA revealed the inhibition of a canonical pathway“Signaling by Rho Family GTPases”and alteration in six upstream regulators.Functional analysis showed that 11 genes were related to“disorder of blood pressure”.We predicted the cis-target genes of DE lncRNAs by the analysis of their neighboring genes.The results revealed the 28 DE lncRNAs adjacent to the 26 protein-coding genes.Many DE mRNAs and cis-target genes of DE lncRNAs have been implicated in the regulation of blood pressure or cell contraction.These results suggested that the dysregulated mRNAs and lncRNAs contributed to the development of GTN tolerance and could serve as potential targets to prevent and reverse GTN tolerance. 展开更多
关键词 Transcriptome Nitroglycerin Tolerance LncRNA Aorta
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Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension 认领 引用 被引量：7
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作者 Andreja Vujanac Vladimir Jakovljevic +6 位作者 Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第4期331-339,共9页
AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension.METHODS:Thirty healthy controls and 39 patients with clinically verified portal hype... AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension.METHODS:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the study.Liver di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler detection.Cross-section area,portal flow and index of vascular resistance were calculated.In collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were determined.Time-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) administration.RESULTS:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate level.Consequently O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid peroxidation.Increased blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood flow.CONCLUSION:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension. 展开更多
关键词 Portal hypertension Endothelium Nitroglycerine Oxidative stress Portal vein haemodynamics
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EFFECT OF ANGIOTENSIN II RECEPTOR ANTAGONIST AND ENDOTHELIN RECEPTOR ANTAGONIST ON NITROGLYCERIN TOLERANCE IN RATS 认领 引用
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作者 张建梅 陈永红 +1 位作者 王晓红 唐朝枢 《Chinese Medical Sciences Journal》 CAS 2001年第2期82-85,共4页
Objective. To investigate whether angiotensin II receptor antagonist and endothelin receptor antagonist can improve the nitroglycerin (Nit) tolerance in vivo. Methods. Twenty- four rats were divided into 4 groups (n=6... Objective. To investigate whether angiotensin II receptor antagonist and endothelin receptor antagonist can improve the nitroglycerin (Nit) tolerance in vivo. Methods. Twenty- four rats were divided into 4 groups (n=6,each): Control group, Nitroglycerin (Nit) group, Nit＋ bosentan group and Nit＋ losartan group. Nitroglycerin tolerance was induced by 2- day treatment of nitroglycerin patch (0.05 mg/h). AngiotensinⅡ receptor antagonist losartan ( 10 mg· kg－ 1· d－ 1 ) and endothelin receptor antagonist bosentan ( 100 mg· kg－ 1· d－ 1 ) were given by gavage for 2 days respectively. Results. The least hypotensive response to sodium nitroprusside (SNP) was observed in Nit group . The effective percentages of hypotensive response to SNP were increased in both Nit＋ losartan group and Nit＋ bosentan group compared with Nit group [(31.95± 4.45 )％ vs (21.00± 3.69 )％ , P< 0.01 and (33.18± 6.16 )％ vs (21.00± 3.69 )％ , P< 0.01 ,respectively]. The maximal vessel relaxation induced by SNP was the same in 4 different groups but the highest EC50 (concentration which produces 50％ of the maximal response to SNP) was found in tolerant group[(34± 10) nmol/ L,P < 0.01 .The ET- 1 amounts in plasma and vascular tissue were markedly increased by 54％ and 60％ in Nit group compared with those in control group(P< 0.01).The ET- 1 amounts in plasma and vascular tissue were decreased by 30％ and 37％ in Nit＋ losartan group compared with those in Nit group (P< 0.01). Conclusion. Endothelin receptor antagonist and angiotensinⅡ receptor antagonist could prevent against the Nit tolerance . 展开更多
关键词 angiotensin II receptor antagonist endothelin receptor antagonist nitroglycerin
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Effectiveness and safety of rocuronium or nitroglycerin plus ropivacaine on pain during intravenous regional anesthesia:A double-blind randomized controlled trial 认领 引用
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作者 Shiva Alikhani Hesameddin Modir +2 位作者 Esmail Moshiri Alireza Kamali Seyed Yosef Shahtaheri 《Journal of Acute Disease》 2024年第4期142-149,共8页
Objective:To compare the effects of adding rocuronium and nitroglycerin to ropivacaine in intravenous regional anesthesia(IVRA)on pain and hemodynamic parameters.Methods:This randomized controlled trial was done in 20... Objective:To compare the effects of adding rocuronium and nitroglycerin to ropivacaine in intravenous regional anesthesia(IVRA)on pain and hemodynamic parameters.Methods:This randomized controlled trial was done in 2023.Participants were 177 candidates for forearm operation surgery under IVRA selected from Valiasr Hospital,Arak,Iran.They were allocated by block randomization to three different groups,namely nitroglycerin group,rocuronium group and control group.Hemodynamic parameters were recorded before tourniquet application up to postoperative recovery time.Sensory block and motor block onset and duration and pain were also evaluated.The data analysis was carried out by IMB SPSS software 20.0.Results:177 Eligible patients were included in study,with 59 in each group.Time to sensory and motor block onset in the nitroglycerin group was significantly less than the other groups and the time of motor block in the rocuronium group was statistically higher than the control and the nitroglycerin groups(P<0.001).Seven participants in the nitroglycerin group experienced headache and three from the rocuronium group experienced dizziness.The side effects occurrence in the nitroglycerin group was more prevalent than in the control and rocuronium groups(P=0.009).Conclusions:Nitroglycerin significantly reduces the time to sensory and motor block onset,while rocuronium is more effective in prolonging the time of motor block.Although there is no difference between nitroglycerin and rocuronium respecting the pain score and opioid need administration,nitroglycerin is associated with a higher prevalence of medication side effects.Therefore,both nitroglycerin and rocuronium can be used as adjuvant for IVRA.The final choice relies on patients’conditions and anesthesiologists’judgment. 展开更多
关键词 Rocuronium Nitroglycerin Ropivacaine Pain Hemodynamic Regional anesthesia Intravenous anesthesia
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Nitroglycerin reduces augmentation index and central blood pressure independent of effects on cardiac preload 认领 引用
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作者 Mike Saddon Karen McNeil Philip Chowienczyk 《Journal of Pharmaceutical Analysis》 CAS 2009年第2期114-119,共6页
Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compare... Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compared effects of NTG with those of lower body negative pressure (LBNP). Hemodynamic measurements were made at rest,during LBNP (10,20 and 30 mmHg,each for 15 min) and after NTG (10,30 and 100 μg/min,each dose for 15 min) in ten healthy volunteers. Cardiac pre-load,stroke volume and cardiac output were assessed by echocardiography. Central pressure augmentation and central systolic pressure were obtained by radial tonometry using a transfer function. Results LBNP (20 mmHg) and NTG (30 μg/min) reduced pre-load (as measured by the peak velocity of the S wave in the superior vena cava) to a similar degree [by (26.8±3.8)% and (23.9±3.4)%,respectively]. Compared to LBNP,NTG reduced systemic vascular resistance [by (32.9±7.5)%,P<0.01],decreased peripheral and central pressure augmentation [by (20.8±3.4)% units and (12.9±2.9)% units,respectively,each P<0.01]. Conclusion These results suggest that a reduction in pre-load does not explain reduction in pressure augmentation and central systolic blood pressure by NTG and that these effects are mediated through arterial dilation. 展开更多
关键词 augmentation index central blood pressure nitroglycerine cardiac preload lower body negative pressure
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Joint Effects of Mexidol and Nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues 认领 引用
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作者 Taasilkan Zhumabaeva Zoya Kuropteva +4 位作者 Zhoomart Moldaliev Nazgul Zhumabaeva Amanai Kadyrbaeva Nurbek Bopoev Zhypargul Abdullaeva 《American Journal of Molecular Biology》 CAS 2021年第3期73-82,共10页
This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays a... This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units;produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes. 展开更多
关键词 Nitroglycerine Liver Tissue Nitric Oxide Mexidol Joint Effect EPR Spectra
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Perioperative Changes of Plasma Endothelin-1 in Patients Undergoing Coronary Artery bypass Grafting and the Effect of Nitroglycerin 认领 引用
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作者 陈鑫 蒋英硕 +2 位作者 徐明 陈振强 郭子黄 《Journal of Nanjing Medical University》 2002年第2期65-68,共4页
Objective To observe the dynamic changes of the plasma ET 1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery. Methods\ Forty patients with coronary artery bypass surgery were di... Objective To observe the dynamic changes of the plasma ET 1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery. Methods\ Forty patients with coronary artery bypass surgery were divided into two group: A and B. Group B received intravenous nitroglycerin 1 μg·kg\+\{ 1\}·min\+\{ 1\} perioperatively. RIA was used to assay the plasma ET 1 level. All the hemodynamic parameters were recorded by the Swan Ganze catheter. Results\ The preoperative plasma ET 1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopulmonary bypass in these patients the plasma ET 1 level was increased significantly until 6 to 8 h after operation. The increasing plasma ET 1 level in group B was less intense than that in group A. There was a positive correlation between the plasma ET 1 level and the mean pulmonary artery pressure in group A 2 and 8 h after operation. Conclusion\ In patients undergoing coronary artery bypass surgery, the increased plasma ET 1 level may be due to the influence of cardiopulmonary bypass partly. Low dose nitroglycerin is beneficial to these patients. 展开更多
关键词 coronary artery bypass endothelin nitroglycerin
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Effects of Nitroglycerine on Erythrocyte Rheology:A Novel Mechanism to Explain the Enhancement of Nutrient Blood Flow to Ischemic Zones 认领 引用
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作者 D.Elizabeth Le Sanjiv Kaul 《South China Journal of Cardiology》 CAS 2007年第3期138-146,共9页
Objectives Nitroglycerine (NTG) enhances coronary blood flow to compromised myocardium is important in relieving ischemia. However, the mechanism for this increase in myocardial blood flow (MBF) is not well defined. I... Objectives Nitroglycerine (NTG) enhances coronary blood flow to compromised myocardium is important in relieving ischemia. However, the mechanism for this increase in myocardial blood flow (MBF) is not well defined. In small vessels and capillaries, relative blood viscosity plays a very important role in determining myocardial vascular resistance (MVR). MVR reduce is due partly to the increase in negative charge of erythrocyte surface. We therefore hypothesized that the enhancement of nutrient blood flow to zones of myocardial ischemia during NTG is partly secondary to reduced MVR and blood flow viscosity. The latter is affected by the negative charge of erythrocyte surface. Methods 6 dogs with LAD flow-limiting stenosis (group 1) and 6 dogs with LAD flow-limiting stenosis and LCx occmusion (group 2) were studied. At baseline and during intracoronary infusions of NTG (0.3-0.6 μg·kg-1·min-1), hemodynamics, MBF (mL·min-1·g-1), whole blood viscosity (WBη, mPa. S), elongation index (EI), eletrophoretic mobility of erythocytes (EME, [μ.s-1)/(V.cm-1)]) and percent wall thickening (%WT) were determined. MVR was calculated using driving pressure/MBF. Results As compared to baseline, no changes in hemodynamics were seen during NTG. MBF increased and MVR decreased significantly in normal bed, the central 25% and the entire of stenosed bed (P<0.05), with a decrease in WBη in both group 1 and group 2 dogs (18.6±9.7 % and 19.2±14.5 %, respectively). However, the % decrease in WBη was proportioned to the % increase in MBF or the % decrease in MVR only in the central 25% of stenosed bed (r=0.87, P<0.001), but not in the entire stenosed bed and normal bed. EI did not show statistically significant differences between during NTG and at baseline, but EME did increase. And the % decrease in WBη during NTG was related to the % increase in EME (r=0.83, P=0.01). Conclusions NTG reduced myocardial vascular resistance and blood viscosity due to the change of negative charge of erythrocyte surface may, in part, be the mechanism of the enhancement of nutrient blood flow to zones of myocardial ischemia. These results provide additional insights into the complex anti-ischemic effects of NTG. 展开更多
关键词 nitroglycerine myocardial blood flow myocardial vascular resistance whole blood viscosity erythrocyte rheology
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“Dermal Nitroglycerin Patch” in Treatment of Preterm Labour 认领 引用
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作者 Kunjan Shah B. D. Gupta Raksha Sharma 《Journal of Biosciences and Medicines》 2015年第11期82-90,共9页
Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of ... Although preterm birth is the delivery before 37 + 0 weeks of gestation, the majority of prema-turity-related complications occur before 33 + 0 weeks of gestation. The need of today is to select the best agent out of the broad spectrum of available tocolytic agents, for providing maximum benefit to unfortunate sufferers of prematurity. The study aims to assess the role of “Dermal Nitroglycerin Patch” in treatment of preterm labour. Method: Study conducted in Department of Obstetrics & Gynecology, NIMS Medical College & Hospital, Jaipur from July 2014-December 2014. A prospective randomized study of 50 women of preterm labor was enrolled after informed consent. Patients were given dermal nitroglycerin patch as tocolytic agent according to study protocol. Result: 1) Results of NTG PATCH are comparable with other tocolytic drugs in terms of successful tocolysis;2) Maternal and fetal outcome is favourable in cases of NTG PATCH USE in preterm labour;3) Side effect profile was also better with NTG Patch. Conclusion: This randomized prospective study lends support to the proportion that Transdermal Nitroglycerine (NTG Patch) may be promising safe, effective, well tolerated, cost effective and non invasive method of tocolysis. 展开更多
关键词 Transdermal Nitroglycerine (NTG Patch) Preterm Labor
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EFFECT OF NEBULIZED NITROGLYCERIN ON CHILDREN WITH VENTRICULAR SEPTAL DEFECT AND PULMONARY HYPERTENSION 认领 引用
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作者 GONG Fang-qi KANG Man-li XIA Cheng-sen 《Journal of Zhejiang University Science》 2000年第2期101-104,共4页
In order to find a safe, simple, effective and selective pulmonary vasodilator, we tested the effectiveness and safety of inhalation of nebulized nitroglycerin (Neb-NTG) by children with ventricular septal defect and ... In order to find a safe, simple, effective and selective pulmonary vasodilator, we tested the effectiveness and safety of inhalation of nebulized nitroglycerin (Neb-NTG) by children with ventricular septal defect and pulmonary hypertension (VSD-PH). Twenty μg/kg Neb-NTG was inhaled by seven children with VSD-PH using face mask during cardiac catheterization. The pulmonary artery pressure (PAP), systemic arterial pressure (SAP) and methemoglobin (MetHb) concentration were measured before and after inhalation of Neb-NTG. After inhalation of Neb-NTG, the PAP and pulmonary to systemic pressure ratio (Pp/Ps) decreased significantly;There was no significant decrease in SAP. The systolic and diastolic PAP decreased respectively 13±4% and 9±7% in 5 min, 21±3% and 13±17% in 10 min, 24±3% and 16±19% in 15 min. The Pp/Ps decreased 12±4% in 5 min, 21±9% in 10 min and 24±6% in 15 min. There was no significant increase in the MetHb level after inhalation of 20 μg/kg of Neb-NTG. The MetHb level was below 1.5%. Neb-NTG is a safe, simple, effective and selective pulmonary vasodilator. 展开更多
关键词 vasodilator nitroglycerin inhalation pulmonary hypertension
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Clinical Effect of Urapidil and Nitroglycerin in Pre-Hospital Care for Hypertensive Emergency 认领 引用
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作者 LIU Wenzheng HAN Yanli 《外文科技期刊数据库（文摘版）医药卫生》 2020年第2期254-256,共3页
Objective: to summarize the efficacy of Urapidil and Nitroglycerin in the treatment of hypertension. Methods: 86 patients with acute hypertension who received treatment in our hospital from April 2019 to September 202... Objective: to summarize the efficacy of Urapidil and Nitroglycerin in the treatment of hypertension. Methods: 86 patients with acute hypertension who received treatment in our hospital from April 2019 to September 2020 were selected as the research subjects. The conventional group was treated with Nitroglycerin. The experimental group was treated with Urapidil on the basis of the conventional group. A comparative study was conducted based on the effective rate of treatment and serum index. Results: the therapeutic effect of the experimental group was better than that of the conventional group, P < 0.05. The serum index of experimental group was better than those of conventional group (P < 0.05). Conclusion: nitroglycerin combined with Urapidil can be effectively applied in the pre-hospital care for hypertensive emergency. The curative effect is exact and the first-aid effect is better. It is worthy of popularization. 展开更多
关键词 Nitroglycerin Urapidil hypertensive emergency first-aid effect
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Nitroglycerin Combined with Metoprolol in the Treatment of Chronic Heart Failure 认领 引用
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作者 HUANG Xiaoling 《外文科技期刊数据库（文摘版）医药卫生》 2020年第2期058-060,共3页
Objective: To study the effect and promotion value of nitroglycerin combined with metoprolol in the treatment of chronic heart failure. Methods: the time span of this study was from August 2018 to August 2019. 120 pat... Objective: To study the effect and promotion value of nitroglycerin combined with metoprolol in the treatment of chronic heart failure. Methods: the time span of this study was from August 2018 to August 2019. 120 patients who met the inclusion criteria were selected and divided into two groups in accordance with the random number table. There were 60 patients in each group. Patients in the control group were treated with nitroglycerin alone, while patients in the observation group were treated with nitroglycerin combined with metoprolol. Analyze the clinical effect of the combined treatment by comparing the disease control state of the two groups of patients after treatment. Results: after the treatment course, the disease control effect of the two groups was evaluated, in terms of the total effective rate, patients in the observation group achieved better results, significantly higher than those in the control group, the difference between the two groups was statistically significant (P < 0.05). Conclusion: nitroglycerin combined with metoprolol in the treatment of patients with chronic heart failure can achieve therapeutic effect better. The patient's symptoms were significantly improved. So nitroglycerin combined with metoprolol can be widely used in clinical treatment. 展开更多
关键词 chronic heart failure treatment effect metoprolol nitroglycerin
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Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models 认领 引用
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作者 Ayca Nur GONUL Ibrahim Ethem TORUN +1 位作者 Yasemin Baranoglu KILINC Erkan KILINC 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2026年第6期615-627,I0015,共13页
Growing evidence suggests that esculetin,a 5-lipoxygenase inhibitor,has pharmacotherapeutic potential due to its various pharmacological properties,such as potent anti-inflammatory,anti-nociceptive,andγ-aminobutyric ... Growing evidence suggests that esculetin,a 5-lipoxygenase inhibitor,has pharmacotherapeutic potential due to its various pharmacological properties,such as potent anti-inflammatory,anti-nociceptive,andγ-aminobutyric acid type A(GABAA)receptor partial agonist activities.However,the effects of this promising agent on migraine remain unexplored.This study therefore examined the impact of esculetin on relevant mechanisms in migraine-like conditions in rats.The systemic effects of esculetin at three distinct doses(5,10,and 20 mg/kg)were tested in a nitroglycerin(NTG)-induced migraine model using in vivo experimental sets.The direct action of esculetin on the release of calcitonin gene-related peptide(CGRP)from critical structures of the trigeminovascular system(trigeminal ganglion,trigeminal nucleus,and meningeal afferents)was also tested in ex vivo experimental sets.Sumatriptan was used as a positive control in both sets of experiments.The in vivo results showed that esculetin reduced NTG-induced mechanical hyperalgesia and decreased trigeminal CGRP and cellular Fos proto-oncogene(c-Fos)levels.It also decreased degranulation and meningeal mast cell numbers.The ex vivo results revealed that esculetin reduced NTG-stimulated CGRP release from trigeminovascular explants,with the exception of meningeal explants.Sumatriptan reversed the NTG-induced changes in both experimental sets.Our findings suggest that esculetin exhibits anti-nociceptive activities in experimental migraine conditions,alleviating trigeminovascular CGRP concentrations and the degranulation of meningeal mast cells.Esculetin may thus represent a therapeutic option for relieving migraine headaches,although further research is needed to confirm this. 展开更多
关键词 Esculetin Neuroinflammation Nitroglycerin model Natural compound Mast cells Calcitonin gene-related peptide(CGRP)
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Letter to the Editor:Reassessing intravenous antihypertensive choice in coronary artery disease-related hypertensive emergencies 认领 引用
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作者 Nikolaos Ktenopoulos Nikias Milaras +3 位作者 Anastasios Apostolos Konstantinos Tsioufis Konstantinos Toutouzas Skevos Sideris 《World Journal of Cardiology》 2026年第7期119-123,共5页
Hypertensive emergencies in patients with established coronary artery disease(CAD)present a therapeutic paradox,that blood pressure must be lowered rapidly to limit end-organ damage,yet excessive or poorly selected ph... Hypertensive emergencies in patients with established coronary artery disease(CAD)present a therapeutic paradox,that blood pressure must be lowered rapidly to limit end-organ damage,yet excessive or poorly selected pharmacologic intervention risks myocardial ischemia and adverse cardiovascular outcomes.In this context,a study by Chaudhary et al,published in the recent issue of the World Journal of Cardiology,provide novel and clinically interesting real-world data comparing intravenous nitroglycerin and labetalol in a large retrospective cohort of CAD patients presenting with hypertensive emergency.Their analysis demonstrates a nuanced trade-off between hemodynamic speed and cardioprotective benefit.While labetalol achieved target blood pressure more rapidly,nitroglycerin was associated with greater absolute blood pressure reduction,fewer bradyarrhythmic events,attenuated cardiac biomarker elevation,shorter intensive care unit and hospital stays,and lower 30-day readmission rates.Although major adverse cardiovascular events did not differ significantly,the observed trends favoring nitroglycerin underscore the importance of ischemia-sensitive blood pressure management in this high-risk population.Importantly,these findings align with the contemporary guideline principles that prioritize myocardial perfusion and preload reduction in CAD-associated hypertensive crises.Despite the inherent limitations of the retrospective,single-center analyses,this study advances the evidence base by focusing specifically on CAD patients in a resourceconstrained setting and by incorporating clinically meaningful utilization outcomes.Collectively,the data support a more deliberate,phenotype-driven approach to agent selection in hypertensive emergencies,positioning nitroglycerin as a preferential option when myocardial ischemia is a central concern,while reinforcing the need for prospective,randomized validation. 展开更多
关键词 Hypertensive emergencies Coronary artery disease Nitroglycerin Labetalol Intravenous antihypertensive therapy Myocardial ischemia
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Effect of intravenous nitroglycerin on hemodynamics in infants and children with congestive heart failure 认领 引用 被引量：7
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作者 曾和平 孙力安 +1 位作者 李万镇 杜军保 《Chinese Medical Journal》 SCIE CAS 2000年第4期40-43,共4页
Objective To understand the effect of intravenous nitroglycerin (NTG) on hemodynamics in infants and small children with congestive heart failure secondary to congenital cardiac defect of left to right shunt Methods H... Objective To understand the effect of intravenous nitroglycerin (NTG) on hemodynamics in infants and small children with congestive heart failure secondary to congenital cardiac defect of left to right shunt Methods Heart rate, blood pressure and total peripheral resistance were monitored continuously Echocardiography was used to measure ejection fraction, fractional shortening, end diastolic volume index of left ventricle, pulmonary capillary wedge pressure, pulmonary artery mean pressure and left ventricular wall stress before uhe use and during 0 5, 1 0, 1 5, 2 5, and 5 0?μg·kg 1 ·min 1 dosages of nitroglycerin (NTG) Results There was no significant difference in the indexes of heart rate, blood pressure, ejection fraction and fractional shortening of left ventricle, stroke volume index, cardiac output index, end diastolic volume index before the use and after the use of NTG Pulmonary capillary wedge pressure decreased from 15 5±2 3?mm?Hg before the use of NTG to 14 3±2 2?mm?Hg after the use of 0 5?μg·kg 1 ·min 1 NTG ( P <0 05), minimum to 12 3±2 4?mm?Hg; left ventricular wall stress Ⅰ, Ⅱ and Ⅲ decreased from 407±65? dyn·cm 2 ·10 3, 166±48?dyn·cm 2 ·10 3, 255±52? dyn·cm 2 ·10 3 to 357±75?dyn·cm 2 ·10 3, 136±48? dyn·cm 2 ·10 3, 218±52?dyn·cm 2 ·10 3 ( P <0 05), minimum to 321±50?dyn·cm 2 ·10 3, 114±42? dyn·cm 2 ·10 3, 187±42?dyn·cm 2 ·10 3, respectively Total peripheral resistance and pulmonary artery mean pressure were decreased when the dosage of intravenous NTG was increased to above 2 5?μg·kg 1 ·min 1 ( P <0 05) There was no statistical difference in the above indexes of the different dosages Conclusion Congestive heart failure secondary to congenital cardiac defect of left to right shunt in infants and small children is the indication of using intravenous NTG which could improve hemodynamics There was different selectivity in dosage between arterial and venous vasodilatation, and the change in hemodynamics was independent of dosage The dosages of 0 5-1 0?μg·kg 1 ·min 1 NTG are recommended when the decrease of cardiac preload is the main point of therapy of heart failure 展开更多
关键词 intravenous nitroglycerin hemodynamics congestive heart failure congenital heart disease
含能增塑剂合成策略及其应用研究进展 认领 引用
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作者 徐若千 PAL YASH +3 位作者 武杨 陈妍慧 汪营磊 张俊林 《火炸药学报》 EI CAS CSCD 北大核心 2026年第1期1-21,I0001,共21页
含能增塑剂是增强炸药和推进剂系统的机械性能、加工性和整体性能的基本功能性添加剂,同时将满足对更高能量输出的需求。以核心含能化策略为基准,以叠氮基类、硝基类、硝酸酯基类、硝胺基类和复合基团类含能增塑剂为主体,同时兼顾寡聚... 含能增塑剂是增强炸药和推进剂系统的机械性能、加工性和整体性能的基本功能性添加剂,同时将满足对更高能量输出的需求。以核心含能化策略为基准,以叠氮基类、硝基类、硝酸酯基类、硝胺基类和复合基团类含能增塑剂为主体,同时兼顾寡聚物类、离子液体类特殊含能增塑剂,系统综述了不同类别含能增塑剂的合成策略与基本物化、爆轰等应用特性,对相关化合物的性能进行了归纳与比较。指出叠氮化反应与硝化反应是含能增塑剂实现含能化的主要途径,通过特定骨架与含能基团的结合,将赋予含能增塑剂不同的理化与能量性能,为后续含能增塑剂的结构设计、样品制备与配方应用提供了重要参考。附参考文献130篇。 展开更多
关键词 含能增塑剂 硝化甘油 NG 固体推进剂 叠氮化反应 硝化反应
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The effects of inhalation of nebulized nitroglycerin on dogs with experimental pulmonary hypertension induced by U4661 9 认领 引用 被引量：12
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作者 龚方戚 《Chinese Medical Journal》 SCIE CAS 2000年第5期91-92,共2页
关键词 The effects of inhalation of nebulized nitroglycerin on dogs with experimental pulmonary hypertension induced by U4661 9
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