FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most importan...FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most important properties of FeMnSi-based SMA aseismic materials.However,the low-cycle fatigue behavior of such SMAs,especially the stress-controlled low-cycle fatigue behavior(with ratchetting effect),has not been clearly understood.In this work,the low-cycle fatigue behavior of the FeMnSiCrNi SMAs subjected to stress-controlled cyclic tension–compression loads is investigated,and the effects of temperature,loading frequency,stress amplitude,and stress ratio are addressed.By analyzing the cyclic stress–strain response,fatigue fracture surface morphology,dissipation energy,ratchetting strain,and equivalent damping ratio,the mechanisms behind the temperature-,loading frequency-,stress amplitude-,and stress ratio-dependent low-cycle fatigue behavior are discussed.The results show that the plasticity,martensitic transformation,and/or the ratchetting strain caused by their tension–compression asymmetry are the decisive factors affecting the low-cycle fatigue behavior of FeMnSiCrNi SMAs.展开更多
Researchers have achieved remarkable control over material properties by designing novel architectures,particularly for tuning Poisson’s ratio.Despite abundant existing approaches,significant design space remains une...Researchers have achieved remarkable control over material properties by designing novel architectures,particularly for tuning Poisson’s ratio.Despite abundant existing approaches,significant design space remains unexplored.This work presents two metamaterial designs exhibiting directionally dependent zero Poisson’s ratio,i.e.,one-way zero Poisson’s ratio.In other loading directions,these metamaterials display positive or negative Poisson’s ratio.This selectivity stems from a mode switching mechanism between“unbuckling”and“buckling”of well-designed members within the metamaterials.Theoretical analysis reveals the conditions governing this mode switch,numerical simulation and experiments confirm the one-way Poisson’s effect.Furthermore,the high stiffness contrast within these buckling-prone members yields a pronounced asymmetry in equivalent moduli of the metamaterials under tension and compression,breaking the inherent symmetry of the elastic matrix of conventional materials.This asymmetry is then exploited to design metamaterial beams with asymmetric bending stiffness.Our findings and the design strategy presented here pave the way for developing advanced metamaterials with previously unattainable and unexpected Poisson’s ratios.展开更多
In mining engineering,dynamic loads acting on the surrounding rock induce irreversible damage.The damage is further exacerbated by water exudation from filling bodies or groundwater in the surrounding rock.Understandi...In mining engineering,dynamic loads acting on the surrounding rock induce irreversible damage.The damage is further exacerbated by water exudation from filling bodies or groundwater in the surrounding rock.Understanding the propagation and energy characteristics of stress waves in damaged surrounding rock is essential for improving the stability of underground structures.Hence,in this study,an improved triaxial Split Hopkinson Pressure Bar(SHPB)testing system was used to prepare four sets of impact-damaged and water-soaked specimens with varying length-to-diameter ratios in the laboratory,followed by dynamic triaxial compression testing.Test results indicate that,following dynamic impact and water soaking,the propagation of stress waves in rock is altered.Compared with intact specimens,impact-damaged and water-soaked specimens(IDWS)show a reduction in both transmission and reflection coefficients,thereby enhancing their energy absorption capacity and decreasing transmitted and reflected energy.The length(length-to-diameter ratio)of the specimen and the peak of the incident wave also affect stress wave propagation.Under the same incident peak value,the transmission coefficient increases with larger length-to-diameter ratios,whereas the reflection coefficient decreases.Similarly,the energy carried by the stress wave is influenced by specimen length:as the length grows,the energy absorbed per unit volume declines.When using energy absorbed per unit volume to characterize the dynamic triaxial strength of rock,the length-to-diameter ratio effect on strength is not pronounced.展开更多
Dear Editor,Dera et al.1 report that neutrophil-to-lymphocyte(NLR)and monocyte-to-lymphocyte(MLR)ratios differ across fasting-glucose and HbA1c strata in 3545 Saudi adults,concluding that these indices“could serve as...Dear Editor,Dera et al.1 report that neutrophil-to-lymphocyte(NLR)and monocyte-to-lymphocyte(MLR)ratios differ across fasting-glucose and HbA1c strata in 3545 Saudi adults,concluding that these indices“could serve as valuable indicators”of dysglycemia.Although the dataset is sizeable,several issues temper that inference.展开更多
Self-sustaining microalgal-bacterial membrane photobioreactors(SSMB-MPBRs)have attracted growing attention due to energy conversation and carbon reduction potential.However,microalgae proliferation,which is essential ...Self-sustaining microalgal-bacterial membrane photobioreactors(SSMB-MPBRs)have attracted growing attention due to energy conversation and carbon reduction potential.However,microalgae proliferation,which is essential for pollutant removal,exacerbates membrane fouling,and the underly mechanisms remain unclear.In this study,pollutant removal efficacy and membrane fouling in a SSMB-MPBR process were investigated at different inoculation microalgae to bacteria(M/B)ratios.The intrinsic mechanisms were examined based on algae-bacteria cooperative and competitive interactions.The results showed that pollutant removal efficacy and chlorophyll-a productivity increased,and decreased with the inoculation M/B ratio from 1:1 to 3:1,in line with the rate of algae-bacteria interaction.The highest pollutant removal efficiency(93.65% of chemical oxygen demand(COD),85.42% of total nitrogen(TN),91.65%of total phosphorus(TP))and chlorophyll-αproductivity(0.82 mg/(L·day))were achieved at inoculation M/B ratio of 2:1 due to the selective enrichment of microalgae and their competitions with predominant functional bacteria,which increased the upregulation of functional enzymes and relative metabolism.Similar trends were observed for the fouling behavior,which corresponded to the algae-bacteria competitive interaction.The increased involution stress promoted biosynthesis and hydrophobicity of extracellular polymeric substances(EPS),which,combined with small free microalgae,contributed to a compact bio-cake,and the most significant membrane fouling.These findings provide mechanistic insights into pollutant removal and membrane fouling and highlight the need to optimize algae-bacteria cooperative and competitive interactions to increase the efficiency and sustainability of the SSMB-MPBR process in treating municipal wastewater.展开更多
Mechanochromic materials exhibit changes in their optical properties when exposed to external forces,making them highly valuable for applications,such as mechanical sensing and component damage monitoring.Herein,a fac...Mechanochromic materials exhibit changes in their optical properties when exposed to external forces,making them highly valuable for applications,such as mechanical sensing and component damage monitoring.Herein,a facile and low-cost method for preparing mechano chromic materials is developed based on the ratio luminescence mechanism.Rather than using sensors with complex structural dual chromophore groups,commercially available methyl orange and methylene blue,which exhibit minimal spectral overlap,are incorporated into thermoplastic polyurethane film at a fixed ratio.As the strain increases,the blending film exhibits a pronounced color change,transitioning from bright yellow-green to golden yellow.In the spectra,the ratios of the absorption peaks and the emission peaks for the two dyes have changed.The doping of dyes leads to a reduction in both tensile strength and modulus.However,the material exhibits exceptional strain-induced color-changing performance and hydrophobic properties,which enhance its high applicability for marine engineering and aero space technology.This approach is not only straightforward and costeffective but also offers a novel pathway for the preparation of mechano chromic materials,showcasing significant potential for practical applications and broad future development prospects.展开更多
This study systematically investigated the influence of the extrusion ratio on the mechanical properties and biodegradation behavior of Mg-Zn-Mn-Sr(ZMJ100)alloy microtubes in relation to their microstructure and textu...This study systematically investigated the influence of the extrusion ratio on the mechanical properties and biodegradation behavior of Mg-Zn-Mn-Sr(ZMJ100)alloy microtubes in relation to their microstructure and texture.The fabrication of ultra-precise ZMJ100 microtubes was successfully achieved through a two-step direct extrusion.As the extrusion ratio increased,the grain refinement and texture weakening played a pivotal role in determining the mechanical and biodegradation behavior.The enhancement of tensile strength was ascribed to grain boundary strengthening due to the higher extrusion ratio,notwithstanding weaker basal texture and higher activation of basal slip.The findings indicated a direct correlation between the biodegradation rate and the inverse square root of grain size,as well as the activation amount of basal slip.An increase in the extrusion ratio led to grain refinement and concurrent texture weakening,accelerating selective grain boundary corrosion and micro-galvanic corrosion between differently oriented grains.It is imperative to meticulously regulate both the grain size and basal texture by calibrating the process parameters,such as the extrusion ratio,to ensure optimal service performance of Mg alloy for bioresorbable stent scaffolds.展开更多
Supersonic film cooling demonstrates superior heat reduction and drag-mitigation effects on a streamwise,convex curved wall.However,it remains essential to clarify how to rationally apply supersonic film cooling on su...Supersonic film cooling demonstrates superior heat reduction and drag-mitigation effects on a streamwise,convex curved wall.However,it remains essential to clarify how to rationally apply supersonic film cooling on supersonic aircraft.Therefore,schlieren and particle image velocimetry experiments on supersonic film cooling over a convex wall were conducted in a supersonic wind tunnel,combined with Proper Orthogonal Decomposition(POD)to analyze the influence of different ratios of static pressure on the flow.Through velocity profiles and fluctuations,the dynamic evolution process of the favorable pressure gradient effect on the flow over the convex wall was revealed,which can be divided into three stages:incubation stage(x/h≤27),transition stage(2740).POD analysis indicated that within the range of x/h=33.33-53.33,the cumulative energy contribution of the first 15 POD modes increased with increasing RSP;however,an opposite trend was observed in the range of x/h=53.33-73.33.Turbulence analysis further identified a significant mechanistic shift during the flow process:within the film exit height(y/h<1),the film significantly reduced negative Reynolds stress by suppressing the recirculation zone;whereas in the downstream region,as the flow transition completed,turbulent mixing became the dominant mechanism,leading to the reappearance of negative Reynolds stress.This work deepens the understanding of the flow mechanism of supersonic film cooling over a convex wall under varying static pressure ratios,providing a reference for the rational application of supersonic film cooling to achieve efficient heat reduction and drag mitigation during the flight of supersonic aircraft.展开更多
The conventional optical coherence tomography angiography(OCTA)algorithm is implemented in the linear domain,which may lead to the neglect of weak blood flow information.Logarithmic transformation is widely used in si...The conventional optical coherence tomography angiography(OCTA)algorithm is implemented in the linear domain,which may lead to the neglect of weak blood flow information.Logarithmic transformation is widely used in signal analysis to improve the contrast of weak signals.However,decorrelation-based OCTA in the logarithmic domain is also sensitive to the signal-to-noise ratio(SNR)even in high SNR regions,introducing strong flow artifacts that severely reduce the blood vessel contrast.A metric—static-to-dynamic ratio(SDR)—was used to quantify weak flow signals,and a weak flow model among decorrelation,SDR,and SNR was established.Based on this model,we proposed a log-scale inverse SDR-based OCTA method(logiSDR-OCTA),which simultaneously and effectively reduces SNR-induced flow artifacts in static regions and prevents the attenuation of the flow signal in dynamic regions.The in vivo imaging experiments demonstrated that the contrast of the mouse brain logiSDR images was 2.43 times that of linear-scale decorrelation images and 2.71 times that of log-scale subtraction images;the contrast of the human retina logiSDR images was 4.91 times that of linear-scale decorrelation images and 3.56 times that of log-scale subtraction images.展开更多
Background:Nutritional status is closely associated with cancer outcomes.However,no previous study has investigated the albumin-to-globulin ratio(AGR),a widely used assessment indicator of nutritional status,in the co...Background:Nutritional status is closely associated with cancer outcomes.However,no previous study has investigated the albumin-to-globulin ratio(AGR),a widely used assessment indicator of nutritional status,in the context of radical radiotherapy prognosis for elderly patients diagnosed with esophageal squamous cell carcinoma(ESCC).As such,the present study aimed to explore the prognostic significance of pre-radiotherapy AGR in elderly patients with ESCC undergoing radical radiotherapy.Methods:Data from 136 elderly patients with ESCC,who underwent radical radiotherapy between 2014 and 2020 at the Radiotherapy Department of the Second Affiliated Hospital,Xi'an Jiaotong University(Xi'an,China),were retrospectively analyzed.The optimal cutoff value and predictive efficiency of pre-radiotherapy AGR were determined.The association between the AGR and clinicopathological features of patients with ESCC was analyzed separately.As a predictive indicator,the prognostic significance of the AGR was assessed using Kaplan-Meier survival curves,as well as univariate and multivariate analyses using Cox regression modeling.Results:The optimal cutoff for pre-radiotherapy AGR was 1.535,accompanied by a specificity of 0.692,a sensitivity of 0.644,and an area under the receiver operating characteristic curve of 0.723.The AGR exhibited a significant association with TNM,T,and N stages(p<0.05)in elderly patients with ESCC.Kaplan-Meier survival curve analysis revealed that a lower AGR before radiotherapy was associated with poorer overall survival in elderly patients(24.39 vs 66.81 months;p<0.05).The pre-radiotherapy AGR(p=0.023),N stage(p=0.004),and age(p=0.020)were independent risk factors for ESCC in elderly patients.Conclusions:The AGR was an independent prognostic marker for elderly patients with ESCC undergoing radical radiotherapy and demonstrated potential as an auxiliary reference indicator for prognostic stratification.展开更多
This study investigated the effects of essential-to-total amino acid(E:T)ratios in reduced crude protein(CP)diets on broiler performance,gene expression,and cecal microbiota under necrotic enteritis(NE)challenge.A tot...This study investigated the effects of essential-to-total amino acid(E:T)ratios in reduced crude protein(CP)diets on broiler performance,gene expression,and cecal microbiota under necrotic enteritis(NE)challenge.A total of 756 mixed-sex 0-d-old Cobb 500 broilers were assigned to six treatments in a 2×3factorial arrangement,with two challenge conditions(yes or no)and three dietary treatments:17%reduced CP(RCP)with E:T ratio of 0.64(RCP0.64),17%RCP with E:T ratio of 0.68(RCP0.68),and 19%normal CP as control(NCP)from d 9 to 18.Performance was measured from d 8 to 18 post-hatch,while jejunal,spleen,and cecal samples were collected on d 16 for gene expression and microbiota analysis.Results showed a significant interaction between diet and challenge for weight gain(WG;P=0.004)and feed intake(FI;P=0.007).Among unchallenged birds,those fed the RCP0.64 diet achieved WG and FI comparable to control-fed birds and were significantly higher than those fed the RCP0.68 diet(P<0.001).Under the NE challenge,FI was significantly higher in the RCP0.64 group than in the control group(P<0.001).Both RCP diets and NE challenge increased the feed conversion ratio(P<0.001).Gene expression analysis showed a diet×challenge interaction for IgG(jejunum,P=0.045)and IgM(spleen,P=0.042).The NE challenge increased IgM expression only in RCP0.64-fed birds(P=0.012).The main effects showed that the NE challenge upregulated nutrient transporter,immune,and apoptotic genes and downregulated TJP1 and GLUT2(P<0.001)in the jejunum.In the spleen,IL2 and IL6 expressions were significantly lower(P<0.05)in RCP0.64-fed birds than in those fed a control diet.In RCP0.64-fed birds,microbiota differential analysis revealed higher Firmicutes in unchallenged birds but increased pathogenic Clostridium sensu stricto 1 in challenged birds.These findings demonstrate that the RCP0.64diet can maintain WG and FI in healthy birds and partially preserve gut health during NE challenge by modulating immune responses(IgG and IgM)and microbial communities.This dietary strategy could be effective for reducing protein in sustainable poultry production.展开更多
Objective:Cardiovascular disease(CVD)is one of the major chronic non-communicable diseases worldwide,with high incidence and mortality.This study aims to investigate the association of the triglyceride-glucose index-t...Objective:Cardiovascular disease(CVD)is one of the major chronic non-communicable diseases worldwide,with high incidence and mortality.This study aims to investigate the association of the triglyceride-glucose index-to-waist-to-height ratio(TyGI-WHtR)with CVD and its subtypes[myocardial infarction(MI)and stroke]in middle-aged and older Chinese adults.Methods:This prospective cohort study was based on 3 follow-up surveys of the China Health and Nutrition Survey(CHNS)from 2009 to 2015.A total of 5395 participants aged 40 to 80 years who were free of CVD at baseline and had participated in at least 2 survey waves were included.Cox proportional hazards models were used to evaluate the associations of TyGI-WHtR with CVD and its subtypes.Weighted generalized additive models and smooth curve fitting were applied to explore potential nonlinear relationships.Time-dependent receiver operating characteristic(ROC)curves assessed predictive performance,and Kaplan-Meier analysis was used to calculate cumulative incidence of CVD across different groups.Results:During a median follow-up of 72 months(interquartile range:48 to 72 months),210 incident CVD events were recorded,including 126 strokes and 92 MIs.Among them,8 patients had both MI and stroke.After adjustment for confounders,each one-standarddeviation(SD)increase in TyGI-WHtR was associated with a significantly higher risk of incident CVD[adjusted hazard ratio(HR)=1.397,95%confidence interval(CI)1.111 to 1.758]and incident MI(adjusted HR 1.747,95%CI 1.241 to 2.460),while no statistically significant association was observed with stroke(adjusted HR=1.198,95%CI 0.890 to 1.613).Compared with lowest quartile,participants in the highest TyGI-WHtR quartile had significantly increased risks of CVD and MI(both P for trend<0.005),whereas no such trend was observed for stroke(P for trend=0.103).Further analyses revealed a nonlinear association between TyGI-WHtR and CVD.When TyGI-WHtR was<4.804,HR was 2.121(95%CI 1.350 to 3.333);when it was≥4.804,HR was 1.066(95%CI 0.754 to 1.507).The nonlinear inflection point for stroke was 4.477,while the association with MI remained linear[ln(likelihood ratio)=0.212].Time-dependent ROC analysis showed that the area under the curve of TyGI-WHtR for predicting CVD was 0.629,with a sensitivity of 77.3%,and specificity of 43.2%.Conclusion:In middle-aged and older Chinese adults,TyGI-WHtR is an independent risk factor for incident CVD,particularly MI,but is not independently associated with stroke.Moreover,its predictive ability for CVD demonstrates a nonlinear saturation-threshold effect,with risk significantly increased only when TyGI-WHtR is below 4.804.展开更多
Dryland biodiversity–productivity relationships remain poorly resolved.Specifically,the environmental conditions governing the shift between complementarity and mass ratio mechanisms remain unclear,limiting the effec...Dryland biodiversity–productivity relationships remain poorly resolved.Specifically,the environmental conditions governing the shift between complementarity and mass ratio mechanisms remain unclear,limiting the effectiveness of restoration and management strategies.To address this gap,the aim of this study was to investigate the geographical patterns of diversity and biomass production in herbaceous communities along a 2100-km precipitation gradient in North China.We studied howα-andβ-diversity affect community-wide productivity using linear mixed-effects models and piecewise structural equation models,along with rolling-window change-point analyses.In arid regions,biomass productivity was primarily driven by interspecificniche complementarity,where higher functional diversity(FD(α))enhanced resource-use efficiency.However,in semi-arid regions,productivity was regulated by the mass ratio effect,specificallythrough the traits of dominant species,including community weighted mean height and specificleaf area,as these species exploited broader resource spectra with increasing water availability.A critical mechanistic shift occurred at a mean annual precipitation(MAP)threshold of~168 mm(95%CI:152–171 mm;p<0.001).Below this threshold,productivity was driven by diversity-mediated complementarity and stress tolerant strategies.Conversely,as MAP surpassed 168 mm,the system transitioned to mass ratio control,coincident with a shift toward competitive strategies.Overall,our study provides empirical evidence to guide dryland management:prioritising the maintenance of functional diversity in arid communities,while emphasising dominant-trait optimisation(plant height and specificleaf area)in semi-arid communities to maximise aboveground biomass.展开更多
Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte ...Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte engineering currently relies on conventional evaluation criteria of reducing coulombic consumption,which implicitly presume its equivalence to irreversible capacity loss and complicates battery development.We introduce the detrimental ratioρto quantify the fraction of parasitic species that permanently degrades active material.This metric is independent and crucially complements total coulombic consumption for accurate performance evaluation.We systematically investigate multiple electrolyte formulations using high-precision leakage current measurements,open-circuit-voltage experiments,and post-mortem characterizations.Although some electrolytes exhibit similarly low coulombic consumption,they diverge significantly in capacity retention andρ.Especially,dimethyl-carbonate-based localized-high concentration electrolyte can synergically achieve low coulombic consumption and detrimental ratioρduring calendar aging,owing to its chemically inert and structurally resilient solidelectrolyte interface with minimal isolated Si material.By contrast,increasing fluoroethylene carbonate(FEC)additive content suppresses electrolyte breakdown but suffers aggravated chemical degradation of more LixSi isolation for irreversible capacity loss with a risingρ.This study critically reveals that the chemistry-characteristic detrimental ratioρestablishes physically informed performance evaluation to pave the way for accelerating battery development.展开更多
BACKGROUND Peutz-Jeghers syndrome(PJS)features gastrointestinal hamartomatous polyps prone to intussusception,obstruction,bleeding,and malignancy.No effective predictors exist for polyp progression.Peripheral blood sy...BACKGROUND Peutz-Jeghers syndrome(PJS)features gastrointestinal hamartomatous polyps prone to intussusception,obstruction,bleeding,and malignancy.No effective predictors exist for polyp progression.Peripheral blood systemic immune-inflammation index(SII)and blood cell ratios(BCR)correlate with cancer prognosis,but their relationship with PJS polyp size(diameter)/burden(number)remains unknown.This study aims to evaluate the value of this simple and non-invasive method in predicting the polyp burden of PJS.AIM To investigate the correlations of SII and peripheral BCR with clinicopathological features in patients with PJS,and to evaluate their predictive value for gastrointestinal polyp burden in PJS.METHODS Patients with PJS who met the inclusion and exclusion criteria and were treated at the Air Force Medical Center,Chinese People’s Liberation Army from January 1,2020,to December 31,2025,were enrolled in this study.Their clinicopathological data were retrospectively analyzed.Spearman correlation analysis was used to assess the correlations of gastrointestinal polyp size and number with SII,neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and monocyte-to-lymphocyte ratio(MLR).The predictive performance was evaluated using receiver operating characteristic curves.RESULTS A total of 636 PJS patients were enrolled in this study.Polyp burden varied across different gastrointestinal segments.SII,NLR,PLR,and MLR could predict the presence of small bowel polyps in PJS patients and were positively correlated with the number of small bowel polyps(r=0.206,P<0.001;r=0.133,P=0.001;r=0.128,P=0.001;r=0.090,P=0.024,respectively).MLR was identified as an independent risk factor for malignancy in PJS patients[odds ratio(OR)=12.186,P=0.010].The cumulative risks of cancer in PJS patients at ages 40 years,50 years,and 60 years were 23.6%,50.8%,and 66.4%,respectively.The combined model of SII,NLR,PLR,and MLR yielded area under the curve values of 0.779 and 0.774 for predicting large polyps(diameter≥25 mm)and multiple polyps(number≥10),respectively.Multivariate logistic regression analysis showed that PLR(OR=1.004,95%confidence interval:1.001-1.008,P=0.011)was an independent risk factor for multiple small bowel polyps in PJS patients.CONCLUSION The combination of SII,NLR,PLR,and MLR can predict small bowel polyp burden in PJS patients,and holds promise as a non-invasive and cost-effective risk stratification biomarker to facilitate individualized surveillance and early risk intervention in PJS patients.展开更多
Reliable estimation of the fine particle rattler fraction is crucial for understanding the structural and mechanical responses of binary granular systems with large size ratios.However,such estimation is challenged by...Reliable estimation of the fine particle rattler fraction is crucial for understanding the structural and mechanical responses of binary granular systems with large size ratios.However,such estimation is challenged by the general inability to obtain interparticle contact force information directly from experimental images and by the lower accuracy of positional and size identification of fine particles compared with coarse particles.To address these challenges,in this study,we focused on 2D bidisperse granular assemblies with large size ratios(α=7,9,12,and 16)and developed an approach based on Monte Carlo simulation(MCS)that relies solely on the size and positional information of coarse particles,avoiding the need for force-resolved computations.The performance of the method was evaluated against experimental measurements and discrete element method(DEM)simulations.The MCS-based predictions show close agreement with experimental results,with a slight overall overestimation.At low fines content,the approach tends to overestimate the fine particle rattler fraction relative to DEM results,whereas at higher fines content,it underestimates the rattler fraction.Overall,the proposed MCS-based approach enables robust and relatively accurate estimation of the fine particle rattler fraction.This study provides a practical framework for predicting the rattler fraction,contributes to advancing both experimental analysis and theoretical modeling in granular physics,and demonstrates the conceptual extendibility of the MCS framework to more complex 3D packings.展开更多
Chikungunya virus(CHIKV)is a mosquito-borne Alphavirus that has emerged and reemerged[1].Its primary vectors are Aedes(Ae.)aegypti and Ae.albopictus having characteristics that provide effective invasiveness,vector co...Chikungunya virus(CHIKV)is a mosquito-borne Alphavirus that has emerged and reemerged[1].Its primary vectors are Aedes(Ae.)aegypti and Ae.albopictus having characteristics that provide effective invasiveness,vector competence,and vectorial capacity that sets the tone for the global manifestation[2].CHIKV has now been identified in over 110 countries with notable recent expansions into previously unaffected regions most especially in countries with established presence of the vector[3].展开更多
The stress-strain curves of seawater sea-sand recycled aggregate concrete(SSRAC)with different replacement ratios of recycled coarse aggregate(RCA)or sea-sand under different strain rates were studied.The effects of d...The stress-strain curves of seawater sea-sand recycled aggregate concrete(SSRAC)with different replacement ratios of recycled coarse aggregate(RCA)or sea-sand under different strain rates were studied.The effects of different replacement ratios of RCA or sea-sand,and ages on the characteristic parameters of the stress-strain curve and corresponding dynamic increasing factor(DIF)of SSRAC were analyzed.Scanning electron microscopy(SEM)and nanoindentation tests were used to explain the variation of the characteristic parameters from the microscopic point of view.The results show that,when the replacement ratio of RCA or seasand is 50%,the strain rate sensitivity of elastic modulus is higher than that of peak stress;the DIF of peak stress exhibits a pattern of initially decreasing and then increasing with the increasing replacement ratio of RCA or sea-sand.Conversely,the DIF of elastic modulus initially shows an increase followed by a decrease.The introduction of seawater and sea-sand promotes hydration,resulting in a denser microstructure for SSRAC as compared to that of recycled aggregate concrete,which influences its strain rate sensitivity.Finally,a stressstrain prediction model of SSRAC is proposed,which can provide a theoretical basis for its experimental research and engineering application.展开更多
This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-fiel...This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.展开更多
Chronic diseases frequently interact,forming complex comorbidity networks.Recent research published in the World Journal of Gastroenterology by Wang et al has identified that the ratio of serum uric acid to high-densi...Chronic diseases frequently interact,forming complex comorbidity networks.Recent research published in the World Journal of Gastroenterology by Wang et al has identified that the ratio of serum uric acid to high-density lipoprotein cholesterol(UHR)independently predicts the 10-year risk of cardiovascular disease(CVD),particularly in younger individuals,males,and those with central obesity.Individuals with metabolic dysfunction-associated steatotic liver disease represent at high-risk cohort for CVD.In these patients,the risk associated with cardiovascular events significantly surpasses that of liver disease,rendering CVD the primary cause of disability and mortality.The UHR is an emerging composite biomarker that effectively synthesizes indices of inflammation and metabolism,facilitating an assessment of a person’s metabolic and inflammatory status.This biomarker exhibits considerable clinical potential.展开更多
基金The National Natural Science Foundation of China(12202294)the Sichuan Science and Technology Program(2024NSFSC1346)are acknowledged.
摘要FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most important properties of FeMnSi-based SMA aseismic materials.However,the low-cycle fatigue behavior of such SMAs,especially the stress-controlled low-cycle fatigue behavior(with ratchetting effect),has not been clearly understood.In this work,the low-cycle fatigue behavior of the FeMnSiCrNi SMAs subjected to stress-controlled cyclic tension–compression loads is investigated,and the effects of temperature,loading frequency,stress amplitude,and stress ratio are addressed.By analyzing the cyclic stress–strain response,fatigue fracture surface morphology,dissipation energy,ratchetting strain,and equivalent damping ratio,the mechanisms behind the temperature-,loading frequency-,stress amplitude-,and stress ratio-dependent low-cycle fatigue behavior are discussed.The results show that the plasticity,martensitic transformation,and/or the ratchetting strain caused by their tension–compression asymmetry are the decisive factors affecting the low-cycle fatigue behavior of FeMnSiCrNi SMAs.
基金supported by the National Natural Science Foundation of China(Grants Nos.11932002 and 11902004).
摘要Researchers have achieved remarkable control over material properties by designing novel architectures,particularly for tuning Poisson’s ratio.Despite abundant existing approaches,significant design space remains unexplored.This work presents two metamaterial designs exhibiting directionally dependent zero Poisson’s ratio,i.e.,one-way zero Poisson’s ratio.In other loading directions,these metamaterials display positive or negative Poisson’s ratio.This selectivity stems from a mode switching mechanism between“unbuckling”and“buckling”of well-designed members within the metamaterials.Theoretical analysis reveals the conditions governing this mode switch,numerical simulation and experiments confirm the one-way Poisson’s effect.Furthermore,the high stiffness contrast within these buckling-prone members yields a pronounced asymmetry in equivalent moduli of the metamaterials under tension and compression,breaking the inherent symmetry of the elastic matrix of conventional materials.This asymmetry is then exploited to design metamaterial beams with asymmetric bending stiffness.Our findings and the design strategy presented here pave the way for developing advanced metamaterials with previously unattainable and unexpected Poisson’s ratios.
基金funded by the National Key Research and Development Program of China-2023 Key Special Project(Grant No.2023YFC2907400)the Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(Grant No.2023JJ10072)the Science and Technology Innovation Program of Hunan Province(Grant No.2022RC1173).
摘要In mining engineering,dynamic loads acting on the surrounding rock induce irreversible damage.The damage is further exacerbated by water exudation from filling bodies or groundwater in the surrounding rock.Understanding the propagation and energy characteristics of stress waves in damaged surrounding rock is essential for improving the stability of underground structures.Hence,in this study,an improved triaxial Split Hopkinson Pressure Bar(SHPB)testing system was used to prepare four sets of impact-damaged and water-soaked specimens with varying length-to-diameter ratios in the laboratory,followed by dynamic triaxial compression testing.Test results indicate that,following dynamic impact and water soaking,the propagation of stress waves in rock is altered.Compared with intact specimens,impact-damaged and water-soaked specimens(IDWS)show a reduction in both transmission and reflection coefficients,thereby enhancing their energy absorption capacity and decreasing transmitted and reflected energy.The length(length-to-diameter ratio)of the specimen and the peak of the incident wave also affect stress wave propagation.Under the same incident peak value,the transmission coefficient increases with larger length-to-diameter ratios,whereas the reflection coefficient decreases.Similarly,the energy carried by the stress wave is influenced by specimen length:as the length grows,the energy absorbed per unit volume declines.When using energy absorbed per unit volume to characterize the dynamic triaxial strength of rock,the length-to-diameter ratio effect on strength is not pronounced.
摘要Dear Editor,Dera et al.1 report that neutrophil-to-lymphocyte(NLR)and monocyte-to-lymphocyte(MLR)ratios differ across fasting-glucose and HbA1c strata in 3545 Saudi adults,concluding that these indices“could serve as valuable indicators”of dysglycemia.Although the dataset is sizeable,several issues temper that inference.
基金supported by Hebei Natural Science Foundation(No.E2025209010)the Scientific Research Foundation of North China University of Science and Technology。
摘要Self-sustaining microalgal-bacterial membrane photobioreactors(SSMB-MPBRs)have attracted growing attention due to energy conversation and carbon reduction potential.However,microalgae proliferation,which is essential for pollutant removal,exacerbates membrane fouling,and the underly mechanisms remain unclear.In this study,pollutant removal efficacy and membrane fouling in a SSMB-MPBR process were investigated at different inoculation microalgae to bacteria(M/B)ratios.The intrinsic mechanisms were examined based on algae-bacteria cooperative and competitive interactions.The results showed that pollutant removal efficacy and chlorophyll-a productivity increased,and decreased with the inoculation M/B ratio from 1:1 to 3:1,in line with the rate of algae-bacteria interaction.The highest pollutant removal efficiency(93.65% of chemical oxygen demand(COD),85.42% of total nitrogen(TN),91.65%of total phosphorus(TP))and chlorophyll-αproductivity(0.82 mg/(L·day))were achieved at inoculation M/B ratio of 2:1 due to the selective enrichment of microalgae and their competitions with predominant functional bacteria,which increased the upregulation of functional enzymes and relative metabolism.Similar trends were observed for the fouling behavior,which corresponded to the algae-bacteria competitive interaction.The increased involution stress promoted biosynthesis and hydrophobicity of extracellular polymeric substances(EPS),which,combined with small free microalgae,contributed to a compact bio-cake,and the most significant membrane fouling.These findings provide mechanistic insights into pollutant removal and membrane fouling and highlight the need to optimize algae-bacteria cooperative and competitive interactions to increase the efficiency and sustainability of the SSMB-MPBR process in treating municipal wastewater.
摘要Mechanochromic materials exhibit changes in their optical properties when exposed to external forces,making them highly valuable for applications,such as mechanical sensing and component damage monitoring.Herein,a facile and low-cost method for preparing mechano chromic materials is developed based on the ratio luminescence mechanism.Rather than using sensors with complex structural dual chromophore groups,commercially available methyl orange and methylene blue,which exhibit minimal spectral overlap,are incorporated into thermoplastic polyurethane film at a fixed ratio.As the strain increases,the blending film exhibits a pronounced color change,transitioning from bright yellow-green to golden yellow.In the spectra,the ratios of the absorption peaks and the emission peaks for the two dyes have changed.The doping of dyes leads to a reduction in both tensile strength and modulus.However,the material exhibits exceptional strain-induced color-changing performance and hydrophobic properties,which enhance its high applicability for marine engineering and aero space technology.This approach is not only straightforward and costeffective but also offers a novel pathway for the preparation of mechano chromic materials,showcasing significant potential for practical applications and broad future development prospects.
基金supported by the Nano&Material Technology Development Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(No.RS-2022-NR068191).
摘要This study systematically investigated the influence of the extrusion ratio on the mechanical properties and biodegradation behavior of Mg-Zn-Mn-Sr(ZMJ100)alloy microtubes in relation to their microstructure and texture.The fabrication of ultra-precise ZMJ100 microtubes was successfully achieved through a two-step direct extrusion.As the extrusion ratio increased,the grain refinement and texture weakening played a pivotal role in determining the mechanical and biodegradation behavior.The enhancement of tensile strength was ascribed to grain boundary strengthening due to the higher extrusion ratio,notwithstanding weaker basal texture and higher activation of basal slip.The findings indicated a direct correlation between the biodegradation rate and the inverse square root of grain size,as well as the activation amount of basal slip.An increase in the extrusion ratio led to grain refinement and concurrent texture weakening,accelerating selective grain boundary corrosion and micro-galvanic corrosion between differently oriented grains.It is imperative to meticulously regulate both the grain size and basal texture by calibrating the process parameters,such as the extrusion ratio,to ensure optimal service performance of Mg alloy for bioresorbable stent scaffolds.
基金the National Natural Science Foundation of China(No.92271203)the financial support from the China Scholarship Council(CSC)。
摘要Supersonic film cooling demonstrates superior heat reduction and drag-mitigation effects on a streamwise,convex curved wall.However,it remains essential to clarify how to rationally apply supersonic film cooling on supersonic aircraft.Therefore,schlieren and particle image velocimetry experiments on supersonic film cooling over a convex wall were conducted in a supersonic wind tunnel,combined with Proper Orthogonal Decomposition(POD)to analyze the influence of different ratios of static pressure on the flow.Through velocity profiles and fluctuations,the dynamic evolution process of the favorable pressure gradient effect on the flow over the convex wall was revealed,which can be divided into three stages:incubation stage(x/h≤27),transition stage(2740).POD analysis indicated that within the range of x/h=33.33-53.33,the cumulative energy contribution of the first 15 POD modes increased with increasing RSP;however,an opposite trend was observed in the range of x/h=53.33-73.33.Turbulence analysis further identified a significant mechanistic shift during the flow process:within the film exit height(y/h<1),the film significantly reduced negative Reynolds stress by suppressing the recirculation zone;whereas in the downstream region,as the flow transition completed,turbulent mixing became the dominant mechanism,leading to the reappearance of negative Reynolds stress.This work deepens the understanding of the flow mechanism of supersonic film cooling over a convex wall under varying static pressure ratios,providing a reference for the rational application of supersonic film cooling to achieve efficient heat reduction and drag mitigation during the flight of supersonic aircraft.
基金supported by the National Key R&D Program of China(Grant Nos.2021YFF0700503,2022YFC2404201,and 2021YFF0700700)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20240024 and BK20220263)+3 种基金the Strategic Priority Research Program of the Chinese Academy(Grant No.XDB1020000)the Suzhou Pilot Program for Basic Research(Grant No.SSD2023018)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.Y2023087)the National Natural Science Foundation of China(Grant No.62075235)。
摘要The conventional optical coherence tomography angiography(OCTA)algorithm is implemented in the linear domain,which may lead to the neglect of weak blood flow information.Logarithmic transformation is widely used in signal analysis to improve the contrast of weak signals.However,decorrelation-based OCTA in the logarithmic domain is also sensitive to the signal-to-noise ratio(SNR)even in high SNR regions,introducing strong flow artifacts that severely reduce the blood vessel contrast.A metric—static-to-dynamic ratio(SDR)—was used to quantify weak flow signals,and a weak flow model among decorrelation,SDR,and SNR was established.Based on this model,we proposed a log-scale inverse SDR-based OCTA method(logiSDR-OCTA),which simultaneously and effectively reduces SNR-induced flow artifacts in static regions and prevents the attenuation of the flow signal in dynamic regions.The in vivo imaging experiments demonstrated that the contrast of the mouse brain logiSDR images was 2.43 times that of linear-scale decorrelation images and 2.71 times that of log-scale subtraction images;the contrast of the human retina logiSDR images was 4.91 times that of linear-scale decorrelation images and 3.56 times that of log-scale subtraction images.
基金support for this research was provided by the Natural Science Basic Research Program of Shaanxi(No.2023-JC-QN-0986)the National Natural Science Foundation of China(No.82172839).
摘要Background:Nutritional status is closely associated with cancer outcomes.However,no previous study has investigated the albumin-to-globulin ratio(AGR),a widely used assessment indicator of nutritional status,in the context of radical radiotherapy prognosis for elderly patients diagnosed with esophageal squamous cell carcinoma(ESCC).As such,the present study aimed to explore the prognostic significance of pre-radiotherapy AGR in elderly patients with ESCC undergoing radical radiotherapy.Methods:Data from 136 elderly patients with ESCC,who underwent radical radiotherapy between 2014 and 2020 at the Radiotherapy Department of the Second Affiliated Hospital,Xi'an Jiaotong University(Xi'an,China),were retrospectively analyzed.The optimal cutoff value and predictive efficiency of pre-radiotherapy AGR were determined.The association between the AGR and clinicopathological features of patients with ESCC was analyzed separately.As a predictive indicator,the prognostic significance of the AGR was assessed using Kaplan-Meier survival curves,as well as univariate and multivariate analyses using Cox regression modeling.Results:The optimal cutoff for pre-radiotherapy AGR was 1.535,accompanied by a specificity of 0.692,a sensitivity of 0.644,and an area under the receiver operating characteristic curve of 0.723.The AGR exhibited a significant association with TNM,T,and N stages(p<0.05)in elderly patients with ESCC.Kaplan-Meier survival curve analysis revealed that a lower AGR before radiotherapy was associated with poorer overall survival in elderly patients(24.39 vs 66.81 months;p<0.05).The pre-radiotherapy AGR(p=0.023),N stage(p=0.004),and age(p=0.020)were independent risk factors for ESCC in elderly patients.Conclusions:The AGR was an independent prognostic marker for elderly patients with ESCC undergoing radical radiotherapy and demonstrated potential as an auxiliary reference indicator for prognostic stratification.
基金Adisseo S.A.S.,France,partnered with AgriFutures Australia funded this study(RJ-011296)。
摘要This study investigated the effects of essential-to-total amino acid(E:T)ratios in reduced crude protein(CP)diets on broiler performance,gene expression,and cecal microbiota under necrotic enteritis(NE)challenge.A total of 756 mixed-sex 0-d-old Cobb 500 broilers were assigned to six treatments in a 2×3factorial arrangement,with two challenge conditions(yes or no)and three dietary treatments:17%reduced CP(RCP)with E:T ratio of 0.64(RCP0.64),17%RCP with E:T ratio of 0.68(RCP0.68),and 19%normal CP as control(NCP)from d 9 to 18.Performance was measured from d 8 to 18 post-hatch,while jejunal,spleen,and cecal samples were collected on d 16 for gene expression and microbiota analysis.Results showed a significant interaction between diet and challenge for weight gain(WG;P=0.004)and feed intake(FI;P=0.007).Among unchallenged birds,those fed the RCP0.64 diet achieved WG and FI comparable to control-fed birds and were significantly higher than those fed the RCP0.68 diet(P<0.001).Under the NE challenge,FI was significantly higher in the RCP0.64 group than in the control group(P<0.001).Both RCP diets and NE challenge increased the feed conversion ratio(P<0.001).Gene expression analysis showed a diet×challenge interaction for IgG(jejunum,P=0.045)and IgM(spleen,P=0.042).The NE challenge increased IgM expression only in RCP0.64-fed birds(P=0.012).The main effects showed that the NE challenge upregulated nutrient transporter,immune,and apoptotic genes and downregulated TJP1 and GLUT2(P<0.001)in the jejunum.In the spleen,IL2 and IL6 expressions were significantly lower(P<0.05)in RCP0.64-fed birds than in those fed a control diet.In RCP0.64-fed birds,microbiota differential analysis revealed higher Firmicutes in unchallenged birds but increased pathogenic Clostridium sensu stricto 1 in challenged birds.These findings demonstrate that the RCP0.64diet can maintain WG and FI in healthy birds and partially preserve gut health during NE challenge by modulating immune responses(IgG and IgM)and microbial communities.This dietary strategy could be effective for reducing protein in sustainable poultry production.
基金supported by the National Key Clinical Specialty Scientific Research Project(Z2023136)the China Scholarship Council([2020]50)。
摘要Objective:Cardiovascular disease(CVD)is one of the major chronic non-communicable diseases worldwide,with high incidence and mortality.This study aims to investigate the association of the triglyceride-glucose index-to-waist-to-height ratio(TyGI-WHtR)with CVD and its subtypes[myocardial infarction(MI)and stroke]in middle-aged and older Chinese adults.Methods:This prospective cohort study was based on 3 follow-up surveys of the China Health and Nutrition Survey(CHNS)from 2009 to 2015.A total of 5395 participants aged 40 to 80 years who were free of CVD at baseline and had participated in at least 2 survey waves were included.Cox proportional hazards models were used to evaluate the associations of TyGI-WHtR with CVD and its subtypes.Weighted generalized additive models and smooth curve fitting were applied to explore potential nonlinear relationships.Time-dependent receiver operating characteristic(ROC)curves assessed predictive performance,and Kaplan-Meier analysis was used to calculate cumulative incidence of CVD across different groups.Results:During a median follow-up of 72 months(interquartile range:48 to 72 months),210 incident CVD events were recorded,including 126 strokes and 92 MIs.Among them,8 patients had both MI and stroke.After adjustment for confounders,each one-standarddeviation(SD)increase in TyGI-WHtR was associated with a significantly higher risk of incident CVD[adjusted hazard ratio(HR)=1.397,95%confidence interval(CI)1.111 to 1.758]and incident MI(adjusted HR 1.747,95%CI 1.241 to 2.460),while no statistically significant association was observed with stroke(adjusted HR=1.198,95%CI 0.890 to 1.613).Compared with lowest quartile,participants in the highest TyGI-WHtR quartile had significantly increased risks of CVD and MI(both P for trend<0.005),whereas no such trend was observed for stroke(P for trend=0.103).Further analyses revealed a nonlinear association between TyGI-WHtR and CVD.When TyGI-WHtR was<4.804,HR was 2.121(95%CI 1.350 to 3.333);when it was≥4.804,HR was 1.066(95%CI 0.754 to 1.507).The nonlinear inflection point for stroke was 4.477,while the association with MI remained linear[ln(likelihood ratio)=0.212].Time-dependent ROC analysis showed that the area under the curve of TyGI-WHtR for predicting CVD was 0.629,with a sensitivity of 77.3%,and specificity of 43.2%.Conclusion:In middle-aged and older Chinese adults,TyGI-WHtR is an independent risk factor for incident CVD,particularly MI,but is not independently associated with stroke.Moreover,its predictive ability for CVD demonstrates a nonlinear saturation-threshold effect,with risk significantly increased only when TyGI-WHtR is below 4.804.
摘要Dryland biodiversity–productivity relationships remain poorly resolved.Specifically,the environmental conditions governing the shift between complementarity and mass ratio mechanisms remain unclear,limiting the effectiveness of restoration and management strategies.To address this gap,the aim of this study was to investigate the geographical patterns of diversity and biomass production in herbaceous communities along a 2100-km precipitation gradient in North China.We studied howα-andβ-diversity affect community-wide productivity using linear mixed-effects models and piecewise structural equation models,along with rolling-window change-point analyses.In arid regions,biomass productivity was primarily driven by interspecificniche complementarity,where higher functional diversity(FD(α))enhanced resource-use efficiency.However,in semi-arid regions,productivity was regulated by the mass ratio effect,specificallythrough the traits of dominant species,including community weighted mean height and specificleaf area,as these species exploited broader resource spectra with increasing water availability.A critical mechanistic shift occurred at a mean annual precipitation(MAP)threshold of~168 mm(95%CI:152–171 mm;p<0.001).Below this threshold,productivity was driven by diversity-mediated complementarity and stress tolerant strategies.Conversely,as MAP surpassed 168 mm,the system transitioned to mass ratio control,coincident with a shift toward competitive strategies.Overall,our study provides empirical evidence to guide dryland management:prioritising the maintenance of functional diversity in arid communities,while emphasising dominant-trait optimisation(plant height and specificleaf area)in semi-arid communities to maximise aboveground biomass.
基金supported by the U.S.Department of Energy(DOE),Office of Energy Efficiency and Renewable Energy(EERE),Vehicle Technologies Office(VTO)under the Silicon Consortium Seedling project received by Z.H.Coperated for the DOE Office of Science by UChicago Argonne,LLC,under Contract DE-AC02-06CH11357+2 种基金Pacific Northwest National Laboratory(PNNL)was supported by the U.S.DOE,Office of Advanced Research Projects Agency-Energy(ARPA-E)under the EVs4ALL Program with the contract number DE-AC05-76RL01830operated by Battelle for the DOE under Contract DE-AC0576RL01830performed at the Oak Ridge National Laboratory(GMV)and supported by U.S.DOE’s VTO under the Silicon Consortium Program received by G.M.V.and directed by Carine Steinway,Nicolas Eidson Thomas,Thomas Do。
摘要Silicon(Si)is a promising high-capacity anode in lithium-ion batteries but suffers from chronic chemical degradation and capacity fading during calendar aging,greatly hindering its automobile applications.Electrolyte engineering currently relies on conventional evaluation criteria of reducing coulombic consumption,which implicitly presume its equivalence to irreversible capacity loss and complicates battery development.We introduce the detrimental ratioρto quantify the fraction of parasitic species that permanently degrades active material.This metric is independent and crucially complements total coulombic consumption for accurate performance evaluation.We systematically investigate multiple electrolyte formulations using high-precision leakage current measurements,open-circuit-voltage experiments,and post-mortem characterizations.Although some electrolytes exhibit similarly low coulombic consumption,they diverge significantly in capacity retention andρ.Especially,dimethyl-carbonate-based localized-high concentration electrolyte can synergically achieve low coulombic consumption and detrimental ratioρduring calendar aging,owing to its chemically inert and structurally resilient solidelectrolyte interface with minimal isolated Si material.By contrast,increasing fluoroethylene carbonate(FEC)additive content suppresses electrolyte breakdown but suffers aggravated chemical degradation of more LixSi isolation for irreversible capacity loss with a risingρ.This study critically reveals that the chemistry-characteristic detrimental ratioρestablishes physically informed performance evaluation to pave the way for accelerating battery development.
摘要BACKGROUND Peutz-Jeghers syndrome(PJS)features gastrointestinal hamartomatous polyps prone to intussusception,obstruction,bleeding,and malignancy.No effective predictors exist for polyp progression.Peripheral blood systemic immune-inflammation index(SII)and blood cell ratios(BCR)correlate with cancer prognosis,but their relationship with PJS polyp size(diameter)/burden(number)remains unknown.This study aims to evaluate the value of this simple and non-invasive method in predicting the polyp burden of PJS.AIM To investigate the correlations of SII and peripheral BCR with clinicopathological features in patients with PJS,and to evaluate their predictive value for gastrointestinal polyp burden in PJS.METHODS Patients with PJS who met the inclusion and exclusion criteria and were treated at the Air Force Medical Center,Chinese People’s Liberation Army from January 1,2020,to December 31,2025,were enrolled in this study.Their clinicopathological data were retrospectively analyzed.Spearman correlation analysis was used to assess the correlations of gastrointestinal polyp size and number with SII,neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and monocyte-to-lymphocyte ratio(MLR).The predictive performance was evaluated using receiver operating characteristic curves.RESULTS A total of 636 PJS patients were enrolled in this study.Polyp burden varied across different gastrointestinal segments.SII,NLR,PLR,and MLR could predict the presence of small bowel polyps in PJS patients and were positively correlated with the number of small bowel polyps(r=0.206,P<0.001;r=0.133,P=0.001;r=0.128,P=0.001;r=0.090,P=0.024,respectively).MLR was identified as an independent risk factor for malignancy in PJS patients[odds ratio(OR)=12.186,P=0.010].The cumulative risks of cancer in PJS patients at ages 40 years,50 years,and 60 years were 23.6%,50.8%,and 66.4%,respectively.The combined model of SII,NLR,PLR,and MLR yielded area under the curve values of 0.779 and 0.774 for predicting large polyps(diameter≥25 mm)and multiple polyps(number≥10),respectively.Multivariate logistic regression analysis showed that PLR(OR=1.004,95%confidence interval:1.001-1.008,P=0.011)was an independent risk factor for multiple small bowel polyps in PJS patients.CONCLUSION The combination of SII,NLR,PLR,and MLR can predict small bowel polyp burden in PJS patients,and holds promise as a non-invasive and cost-effective risk stratification biomarker to facilitate individualized surveillance and early risk intervention in PJS patients.
基金supported by the National Natural Science Foundation of China(No.51988101).
摘要Reliable estimation of the fine particle rattler fraction is crucial for understanding the structural and mechanical responses of binary granular systems with large size ratios.However,such estimation is challenged by the general inability to obtain interparticle contact force information directly from experimental images and by the lower accuracy of positional and size identification of fine particles compared with coarse particles.To address these challenges,in this study,we focused on 2D bidisperse granular assemblies with large size ratios(α=7,9,12,and 16)and developed an approach based on Monte Carlo simulation(MCS)that relies solely on the size and positional information of coarse particles,avoiding the need for force-resolved computations.The performance of the method was evaluated against experimental measurements and discrete element method(DEM)simulations.The MCS-based predictions show close agreement with experimental results,with a slight overall overestimation.At low fines content,the approach tends to overestimate the fine particle rattler fraction relative to DEM results,whereas at higher fines content,it underestimates the rattler fraction.Overall,the proposed MCS-based approach enables robust and relatively accurate estimation of the fine particle rattler fraction.This study provides a practical framework for predicting the rattler fraction,contributes to advancing both experimental analysis and theoretical modeling in granular physics,and demonstrates the conceptual extendibility of the MCS framework to more complex 3D packings.
摘要Chikungunya virus(CHIKV)is a mosquito-borne Alphavirus that has emerged and reemerged[1].Its primary vectors are Aedes(Ae.)aegypti and Ae.albopictus having characteristics that provide effective invasiveness,vector competence,and vectorial capacity that sets the tone for the global manifestation[2].CHIKV has now been identified in over 110 countries with notable recent expansions into previously unaffected regions most especially in countries with established presence of the vector[3].
基金Funded by the State Key Laboratory of Hydroscience and Engineering(No.sklhse-2024-D-05)the National Natural Science Foundation of China(No.52008304)the Natural Science Foundation of Fujian Province(No.2023J05021)。
摘要The stress-strain curves of seawater sea-sand recycled aggregate concrete(SSRAC)with different replacement ratios of recycled coarse aggregate(RCA)or sea-sand under different strain rates were studied.The effects of different replacement ratios of RCA or sea-sand,and ages on the characteristic parameters of the stress-strain curve and corresponding dynamic increasing factor(DIF)of SSRAC were analyzed.Scanning electron microscopy(SEM)and nanoindentation tests were used to explain the variation of the characteristic parameters from the microscopic point of view.The results show that,when the replacement ratio of RCA or seasand is 50%,the strain rate sensitivity of elastic modulus is higher than that of peak stress;the DIF of peak stress exhibits a pattern of initially decreasing and then increasing with the increasing replacement ratio of RCA or sea-sand.Conversely,the DIF of elastic modulus initially shows an increase followed by a decrease.The introduction of seawater and sea-sand promotes hydration,resulting in a denser microstructure for SSRAC as compared to that of recycled aggregate concrete,which influences its strain rate sensitivity.Finally,a stressstrain prediction model of SSRAC is proposed,which can provide a theoretical basis for its experimental research and engineering application.
基金supported by the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2025ZD005100)by Beijing Geolight Technology Co.,Ltd.under the project“The Impact of Strong Ground Motion on Buildings”(YF-202520).
摘要This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.
基金Supported by the Digestive Diseases Committee of the Chinese Association of Traditional Chinese Medicine-The Youth Empowerment Program,No.202557-006State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,No.LSLSKL20240127+1 种基金Science and Technology Development Fund of Shanghai Pudong New Area,No.PKJ2024-Y19the Investigator-Initiated Trial Program of Shanghai Pudong New Area Health Commission(the Cohort Study Program),No.2025-PWDL-03.
摘要Chronic diseases frequently interact,forming complex comorbidity networks.Recent research published in the World Journal of Gastroenterology by Wang et al has identified that the ratio of serum uric acid to high-density lipoprotein cholesterol(UHR)independently predicts the 10-year risk of cardiovascular disease(CVD),particularly in younger individuals,males,and those with central obesity.Individuals with metabolic dysfunction-associated steatotic liver disease represent at high-risk cohort for CVD.In these patients,the risk associated with cardiovascular events significantly surpasses that of liver disease,rendering CVD the primary cause of disability and mortality.The UHR is an emerging composite biomarker that effectively synthesizes indices of inflammation and metabolism,facilitating an assessment of a person’s metabolic and inflammatory status.This biomarker exhibits considerable clinical potential.