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Inflammatory bone loss and signaling pathways in periodontitis:mechanistic insights and emerging therapeutic strategies 认领 引用 被引量：1
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作者 Rafael Scaf de Molon Rolando Vernal +5 位作者 Gabriela Ezequiel Oliveira Joao Paulo Steffens Edilson Ervolino Leticia Helena Theodoro Jeroen J.J.Pvan den Beucken Sotirios Tetradis 《Bone Research》 SCIE CAS CSCD 2026年第1期1-27,共27页
Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation... Bone resorption is a vital physiological process that enables skeletal remodeling,maintenance,and adaptation to mechanical forces throughout life.While tightly regulated under the physiological state,its dysregulation contributes to pathological conditions such as osteoporosis,rheumatoid arthritis,and periodontitis.Periodontitis is a highly prevalent chronic inflammatory disease driven by dysbiotic biofilms that disrupt the oral microbiome,leading to the progressive breakdown of the periodontal ligament,cementum,and alveolar bone and ultimately resulting in tooth loss.This review outlines the molecular and cellular mechanisms underlying periodontitis,focusing on osteoclastogenesis,the differentiation and activation of osteoclasts,the primary mediators of bone resorption.Key transcriptional regulators,including NFATc1,c-Fos,and c-Src are discussed alongside major signaling pathways such as Mitogen Activated Protein Kinase(MAPK),Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription(JAK/STAT),Nuclear Factor Kappa B(NF-κB),and Phosphoinositide 3-kinase(PI3K)/Akt,to elucidate their roles in the initiation and progression of periodontal bone loss.These pathways orchestrate the inflammatory response and osteoclast activity,underscoring their relevance in periodontitis and other osteolytic conditions.Hallmark features of periodontitis,including chronic inflammation,immune dysregulation,and tissue destruction are highlighted,with emphasis on current and emerging therapeutic strategies targeting these molecular pathways.Special attention is given to small molecules,biologics,and natural compounds that have the potential to modulate key signaling pathways.Although advances in understanding these mechanisms have identified promising therapeutic targets,translation into effective clinical interventions remains challenging.Continued research into regulating bone-resorptive signaling pathways is essential for developing more effective treatments for periodontitis and related inflammatory bone diseases. 展开更多
关键词 NFATc chronic inflammatory disease bone resorption inflammatory bone loss signaling pathways osteoclastogenesis periodontal ligamentcemen dysbiotic biofilms
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Decoding cellular communication networks and signaling pathways in bone,skeletal muscle,and bone-muscle crosstalk through spatial transcriptomics in a young male mouse 认领 引用 被引量：1
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作者 Chuan Qiu Yisu Li +16 位作者 Yun Gong William Sherman Di Tian Weiqiang Lin Zehui Pan Boluwatife Afolabi Vivek Thumbigere Kuanjui Su Jeffrey Deng Yuwei Hou Shashank Mungasavalli Gnanesh Zhe Luo Qing Tian Fernando Sanchez Yiping Chen Hui Shen Hong-Wen Deng 《Bone Research》 SCIE CAS CSCD 2026年第3期920-934,共15页
Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines... Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines,growth factors,and extracellular-matrix(ECM)proteins.The spatial organization of these mediators is critical for maintaining tissue integrity,and its disruption contributes to diseases,such as osteoporosis,sarcopenia,and metabolic syndrome.Despite this importance,spatial transcriptomics(ST)studies of bone-muscle interactions remain limited.Here,we applied 10x Genomics Visium ST with computational tools,e.g.,SMART and CellChat,to deconvolute cell-type composition and characterize cell-cell communication networks and ligand-receptor(L-R)interactions in mouse femur and adjacent skeletal muscle.We identified eight major cell types(erythroid cells,endothelial cells,skeletal muscle cells,osteoblasts,myeloid cells,monocytes/macrophages,mesenchymal stem cells,and adipocytes)with distinct spatial transcriptional profiles and thirteen CellChat-inferred pathways,such as ECM-receptor related(e.g.,COLLAGEN,TENASCIN,THBS)and secreted-signaling involved(e.g.,VEGF)pathways.Representative L-R pairs include Col1a1/Col1a2-Sdc4,mediating osteoblast-to-muscle interactions,and Col4a1-Sdc4,facilitating muscle-to-osteoblast interactions in COLLAGEN,Tnxb-Sdc4 in TENASCIN,supporting muscle-to-osteoblast/muscle/myeloid/endothelial communication,Comp-Sdc4 in THBS,driving monocyte/macrophage-to-osteoblast/muscle signaling,and Vegfa-Vegfr1/Vegfr2 in VEGF,mediating muscle-toendothelial/myeloid signaling.Immunostaining validated colocalization of several representative L-R pairs with their corresponding cells.Additionally,independent mouse and human bone scRNA-seq datasets reproduced most of the pathways and L-R pairs identified in ST,underscoring the robustness and cross-species relevance of our findings.Together,we present an initial spatially resolved transcriptome-wide map of bone-muscle intercellular communication,providing novel insights into molecular crosstalk and establishing groundwork for future studies in musculoskeletal disorders. 展开更多
关键词 skeletal muscle cells bone muscle crosstalk spatial transcriptomics osteoblasts signaling pathways young male mouse musculoskeletal systemenabling bone skeletal muscle
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Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways 认领 引用
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作者 Haiyang Sun Shuhuai Meng +10 位作者 He Cai Zhengyi Xu Kuo Gai Dan Meng Yixin Shi Feng Luo Xibo Pei Jian Wang Anjali P.Kusumbe Qianbing Wan Junyu Chen 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第2期241-257,共17页
Excessive lighting is integral to dentists’daily routines but can impair their vision,affecting personal and professional performance.Most studies focus on acute photodamage,neglecting chronic photo-injury from denta... Excessive lighting is integral to dentists’daily routines but can impair their vision,affecting personal and professional performance.Most studies focus on acute photodamage,neglecting chronic photo-injury from dental lighting and its impact on the blood-retinal barrier homeostasis.An epidemiological survey involving 14523 individuals showed dentists had 3.6 times higher odds of visionrelated issues compared to other occupations(OR=3.639,95%CI:3.064–4.323).Subsequently,chronic photodamage models in rats were created to accurately simulate dental working conditions.Using systematic imaging and gene analysis,including OCT,tissue clearing technology and RNA-sequencing,dental lighting was found to disrupted both inner and outer blood-retinal barriers,reduced retinal blood vessels,and promoted perivascular macrophage recruitment.Among them,the number of capillary branches decreased sharply.Moreover,the activation of inflammatory-related pathways such as NF-κB signaling resulted in the damage of vision-related functional structures in the retina.Notably,among three dental light sources,low-intensity halogen caused minimal retinal damage,whereas blue and white LEDs significantly disrupted blood-retinal barrier homeostasis.This study explored the potential mechanism of dental lighting environment inducing the disruption of blood-retinal barrier homeostasis,and provided essential guidance for dental professionals in selecting light sources,which is conducive to reducing the risk of occupational ocular diseases among dentists. 展开更多
关键词 vascular pathways inflammatory pathways photodamage models chronic dental lighting epidemiological survey dental lighting blood retinal barrier acute photodamageneglecting
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Port sustainability:Synergistic pathways and perspectives for air pollution control and carbon mitigation 认领 引用
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作者 Yu Zhang Chenran Li +2 位作者 Tianjiao Dai Zheng Wang Shaojie Song 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期318-330,共13页
As pivotal interfaces of maritime trade and urban-industrial systems,ports are increasingly challenged by their dual roles in enabling economic activity and generating air pollution and carbon emissions.This review pr... As pivotal interfaces of maritime trade and urban-industrial systems,ports are increasingly challenged by their dual roles in enabling economic activity and generating air pollution and carbon emissions.This review provides a structured assessment of emission characteristics,mitigation technologies,and governance strategies aimed at port sustainability.It first delineates the primary emission sources—ships,cargo handling equipment,land transport,and on-site energy systems—focusing on key pollutants such as NOx,SO2,PM2.5,VOCs,and CO2.Synergistic technological pathways are then examined,including ship-based alternatives such as shore power,low-carbon fuels,and carbon capture and storage,along with port-side electrification,operational optimization,and integration of renewables.The review further assesses how regulatory frameworks—encompassing mandatory rules,market-based incentives,and international cooperation—govern the adoption and scaling of these technologies.Drawing on case studies from both developed and developing economies,the review identifies enabling factors including institutional coordination and technological readiness,alongside persistent barriers such as fragmented governance and limited financing.It concludes by outlining four strategic imperatives:accelerating scalable technologies diffusion,enhancing multilevel governance alignment,embedding port transitions within broader urban and industrial systems,and promoting equity through just transition frameworks.By integrating technical and institutional dimensions,the review provides a forward-looking roadmap for low-carbon,clean,and resilient port development. 展开更多
关键词 Green port GHGs mitigation Air pollution control Synergistic pathways Multilevel governance
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Changes of bone remodeling,cartilage damage and apoptosis-related pathways in broilers with femoral head necrosis 认领 引用
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作者 Yaling Yu Hongfan Ge +3 位作者 Hang Gao Yanyan Zhang Kangping Liu Zhenlei Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期788-802,共15页
Femoral head necrosis(FHN) is a common leg disorder in the poultry industry often leads to significant cartilage damage.The mechanism behind abnormal apoptosis in FHN broilers,leading to cartilage damage,remains uncle... Femoral head necrosis(FHN) is a common leg disorder in the poultry industry often leads to significant cartilage damage.The mechanism behind abnormal apoptosis in FHN broilers,leading to cartilage damage,remains unclear;although endoplasmic reticulum stress(ERS) has been found to play a role in glucocorticoid-induced FHN broilers.In this study,we collected samples from broilers with femoral head separation(FHS) and femoral head separation accompanied with growth plate lacerations(FHSL) in a broiler farm.The aim was to investigate the potential association between the severity of FHN,bone remodeling and cartilage damage.Additionally,primary chondrocytes were treated with methylprednisolone(MP) to construct an in vitro FHN model,followed by inhibition or activation of ERS or hypoxia inducible factor-1α(HIF-1α) to further investigate the mechanism of apoptosis in cartilage.The results suggested that cartilage appeared to be the appropriate tissue to investigate the potential mechanisms of FHN,as the degree of cartilage damage was found to be closely related to the severity of the disease.Bone quality was only affected in FHSL broilers,although factors related to bone metabolism were significantly altered among FHN-affected broilers.In addition,cartilage in FHN-affected broilers exhibited high levels of apoptosis and upregulated expression of ERS-related and HIF-1α,which was consistent with both in vivo and in vitro findings after MP treatment.The results were further supported by treatment with HIF-1α or ERS inhibition or activation.In conclusion,bone remodeling and cartilage homeostasis were affected in FHN broilers,but only cartilage damage was significantly exacerbated with FHN development.Moreover,activation of ERS or HIF-1α resulted in apoptosis in cartilage,thus exhibiting a significant correlation with FHN severity. 展开更多
关键词 femoral head necrosis bone remodeling cartilage homeostasis apoptosis-related pathways
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Salvia miltiorrhiza-derived carbon dots enhance heat and cold stress tolerance through BrSPL11.1-mediated ascorbic acid biosynthesis and recycling pathways in flowering Chinese cabbage 认领 引用
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作者 Jiajing Zeng Juan Li +5 位作者 Pengli Wang Dalian Lu Min Zhong Yunyan Kang Juxian Guo Xian Yang 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期881-904,共24页
Salvia miltiorrhiza-derived carbon dots(SmCDs)have a potent antioxidant capacity.Squamosa promoter-binding protein-like(SPL)transcription factors respond to both heat and cold stress.However,the molecular mechanisms u... Salvia miltiorrhiza-derived carbon dots(SmCDs)have a potent antioxidant capacity.Squamosa promoter-binding protein-like(SPL)transcription factors respond to both heat and cold stress.However,the molecular mechanisms underlying the regulation of both high temperature(HT)and low temperature(LT)stress by SmCDs through SPL-mediated ascorbate(AsA)biosynthesis and recycling pathways remain unexplored.Therefore,we systematically identified 29 BrSPLs and 16 genes related to AsA biosynthesis and recycling pathways in flowering Chinese cabbage.BrSPL11.1 and three genes(BrGalDH,BrAPX,and BrDHAR1)involved in AsA biosynthesis and recycling pathways were induced by both HT and LT,and their expression patterns were modulated by SmCDs.Functional analyses revealed that the expression of BrGalDH,BrAPX,and BrDHAR1 was suppressed in BrSPL11.1 over expressing(BrSPL11.1-OE)plants,leading to reduced AsA content and reactive oxygen species(ROS)accumulation,as well as enhanced sensitivity to thermal extremes.Conversely,atspl11.1 showed inverse phenotypic and biochemical trends.BrSPL11.1 directly bound to the promoters of BrGalDH,BrAPX,or BrDHAR1 and suppressed their transcription.Silencing BrGalDH,BrAPX,or BrDHAR1 decreased the AsA content and increased ROS accumulation,decreasing HT and LT resistance.SmCDs application effectively elevated the AsA content and attenuated ROS accumulation,alleviating oxidative damage under both stress conditions.Our results established that BrSPL11.1 acts as a dual-temperature stress repressor and that SmCDs enhance HT and LT resistance by regulating BrSPL11.1-mediated AsA biosynthesis and recycling pathways. 展开更多
关键词 Flowering Chinese cabbage Carbon dots SPL transcription factors Temperature stress AsA-GSH pathways
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The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction 认领 引用
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作者 Kaijie Yan Sihe Gong +4 位作者 Yanni Li Zhonghong Shi Yimin Bao Jing Leng Ke Ning 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期279-288,共10页
Taohong Siwu Decoction(THSWD), a traditional Chinese medicinal formulation, has been demonstrated to significantly modulate key signaling pathways implicated in atherosclerosis(AS). This review examines the complex me... Taohong Siwu Decoction(THSWD), a traditional Chinese medicinal formulation, has been demonstrated to significantly modulate key signaling pathways implicated in atherosclerosis(AS). This review examines the complex mechanisms through which THSWD influences critical pathways, including nuclear factor kappa-B(NF-κB), phosphatidylinositol 3-kinase(PI3K)/serine-threonine kinase(AKT), Toll-like receptor 4(TLR4), mitogen-activated protein kinase(MAPK), and mammalian target of rapamycin(mTOR), that play pivotal roles in AS pathogenesis. By synthesizing experimental evidence and existing literature, the review summarizes how THSWD and its bioactive constituents regulate these signaling cascades to ameliorate AS. Furthermore, it highlights the distinctive therapeutic advantages of traditional Chinese medicine(TCM) compounds in managing chronic diseases driven by multi-target and multifactorial mechanisms. Analyzing disease targets from the perspective of signaling pathways enhances the scientific validation of clinical efficacy for such formulations, thereby offering novel insights for future research. 展开更多
关键词 Atherosclerosis Traditional Chinese medicine Taohong Siwu Decoction Signaling pathways
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Integrative catalytic pairs:Four functional pathways toward next-generation multi-intermediate catalysis 认领 引用
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作者 Li Li Yongfu Sun Yi Xie 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第5期494-495,I0012,共2页
Single-atom catalysts(SACs)have long served as ideal platforms for establishing precise structure-activity relationships in heterogeneous catalysis[1,2].Their atomically dispersed active centers maximize metal utiliza... Single-atom catalysts(SACs)have long served as ideal platforms for establishing precise structure-activity relationships in heterogeneous catalysis[1,2].Their atomically dispersed active centers maximize metal utilization and enable fundamental insights into CO/CO2reduction,oxygen and nitrate reduction,methane activation,and selective hydrogenation[3-8]. 展开更多
关键词 single atom catalysts atomically dispersed active centers heterogeneous catalysis their functional pathways structure activity relationships heterogeneous catalysis next generation multi intermediate catalysis selective hydrogenation
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The Ideological System,Development Architecture,and Advancement Pathways of the China-ASEAN Community With a Shared Future 认领 引用
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作者 Xu Liping 《Contemporary World》 2026年第3期13-20,共8页
The year 2026 marks the fifth anniversary of the establishment of the China-ASEAN Comprehensive Strategic Partnership.Since President Xi Jinping proposed jointly building a closer China-ASEAN community with a shared f... The year 2026 marks the fifth anniversary of the establishment of the China-ASEAN Comprehensive Strategic Partnership.Since President Xi Jinping proposed jointly building a closer China-ASEAN community with a shared future in 2013,the initiative has evolved in both substance and depth,growing from concept to practice and from bilateral cooperation to multilateral cooperation. 展开更多
关键词 development architecture comprehensive strategic partnership bilateral cooperation multilateral cooperation ideological system China asean community advancement pathways shared future
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Microwave assisted metal-free catalysts preparation from waste plastics for efficient pollutants degradation: Interesting relationship between plastic types and nonradical/radical pathways 认领 引用 被引量：1
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作者 Denghong Zhao Mingwei Yang +9 位作者 Yichuan Zhang Long Qin Hang Liu Hongji Chen Maoguo Tan Zhongyi Yin Bin Sun Yu Shen Haijiao Xie Heyan Jiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期371-378,共8页
To implement the principle of utilizing waste to address waste issues,porous carbon catalytic materials,prepared through a straightforward process involving NaOH-assisted microwave pyrolysis of ubiquitous waste plasti... To implement the principle of utilizing waste to address waste issues,porous carbon catalytic materials,prepared through a straightforward process involving NaOH-assisted microwave pyrolysis of ubiquitous waste plastics,were employed to degrade pollutants via peroxymonosulfate(PMS) activation.Polyethylene terephthalate(PET) derived P1S2 exhibited characteristics of defects enrichment and C=O formation,while H1S2,prepared by carbonization of high-density polyethylene(HDPE),possessed a large number of C-OH and defects.Metal-free catalysts P1S2 and H_i S2 exhibited excellent tetracycline(TC) degradation performance,with the rate constants up to 0.303 min-1 and 0.235 min-1.Interestingly,mechanism studies demonstrated that the types of waste plastic precursor had a significant impact on the pathways involved in TC degradation.Specifically,carbon defects in p1S2 dominated the electron transfer nonradial degradation pathway of TC;However,C-OH in H1S2 served as the reactive site for main active species SO4·-/·OH generation,initiating a free radical pathway.In addition,by combining Fukui function calculation and LC-MS test during the TC degradation process,the vulnerable sites attacked by active species were identified;different degradation routes of TC in nonradial and radial pathways were proposed and discussed.Furthermore,the toxicity of all intermediates was analyzed using the toxicity assessment software.This study offers fresh insights into the critical role of carbocatalysts derived from various waste plastics in both nonradical and radical activation processes of PMS. 展开更多
关键词 Waste plastic Porous carbon material Microwave pyrolysis Peroxymonosulfate Nonradicaladical pathways
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The influence of a changing Arctic on midlatitude climate and extremes:a review of pathways and uncertainties 认领 引用 被引量：1
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作者 GAO Yizhou YANG Zibo +6 位作者 ZHANG Ruonan LIU Jiping LEI Ruibo YOU Qinglong YE Kunhui HUA Wenjian ZOU Chuntao 《Advances in Polar Science》 CSCD 2026年第2期123-141,共19页
In the context of global warming,the ongoing reduction in Arctic sea ice and associated influences have become a focal point.Many studies have linked Arctic changes to extreme weather and climate events in the Norther... In the context of global warming,the ongoing reduction in Arctic sea ice and associated influences have become a focal point.Many studies have linked Arctic changes to extreme weather and climate events in the Northern Hemisphere midlatitudes,including cold spells,heatwaves,droughts,storms,and wildfires.However,the causality and physical pathways of the Arctic–midlatitude linkage remain controversial and highly uncertain,hindering the attribution of extremes to Arctic climate change.This study builds on extensive previous research and reviews recent progress in understanding the influence of Arctic amplification and sea ice loss on midlatitude climate variability,as well as the associated uncertainties.The impacts of Arctic changes on the midlatitude weather and climate are substantially mediated by the jet streams,Rossby waves,transient eddy-mean flow interactions,and the stratospheric polar vortex.Despite the enhanced comprehension of mechanisms and pathways,the aforementioned Arctic-midlatitude linkage remains debated.The ongoing prospection is attributed to the noise arising from intrinsic atmospheric variability,Arctic nonlinearities,lower latitude factors,and climate background state.The present study has sought to elucidate the intricacies of the Arctic-midlatitude linkage,with a particular focus on the ramifications for mean and extreme weather and climate conditions in Eurasia and North America.This study also specifically introduces discussions about the sources of uncertainty and possible underlying causes that need to be addressed. 展开更多
关键词 Arctic change Arctic-midlatitude linkage mechanisms pathways uncertainties
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Comparative assessment of novel nematicide trifluenfuronate and fosthiazate on soil ecosystem:From microbial community structure to KEGG functional pathways 认领 引用
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作者 Jiabin Chen Guo Li +5 位作者 Jie Liu Xue Yuan Gongwen Zhao Xiaoying Yang Suzhen Huang Zheng Zheng 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期409-419,共11页
In recent years,the increasing demand for environmentally friendly pesticides in agricultural production has driven the development of novel pesticides characterized by high efficiency,low toxicity,and improved enviro... In recent years,the increasing demand for environmentally friendly pesticides in agricultural production has driven the development of novel pesticides characterized by high efficiency,low toxicity,and improved environmental compatibility.Simultaneously,greater emphasis is being placed on evaluating their impact on the soil ecosystem to ensure sustainable pesticide use and the stability of agroecosystems.In this study,we employed 16S rRNA gene high-throughput sequencing and metagenomic analysis to compare the effects of the novel nematicide trifluenfuronate and the commonly used nematicide fosthiazate on soil physicochemical properties,bacterial community structure,and metabolic functions in cucumber cultivation soils.Results showed that soil enzyme activity,microbial community structure and diversity exhibited the most significant differences on day 7 following nematicide application but stabilized by day 100.Both nematicide type and concentration were key factors influencing bacterial community structure.Compared to fosthiazate,trifluenfuronate more significantly enhanced soil bacterial community abundance while exerting fewer negative impacts on related enzyme activities and KEGG pathways.In addition,fosthiazate preferentially regulated membrane-associated efflux genes,whereas trifluenfuronate primarily interfered with the transcriptional regulation of target genes to mitigate antibiotic stress.These alterations in microbial community structure and function led to changes in soil nutrient bioavailability.This made the trifluenfuronate treatment group have higher available nitrogen and phosphorus content to supply to cucumber.This research contributes to understanding their ecological effects and paves the way for future sustainable pesticide research. 展开更多
关键词 Novel nematicide Metagenomic analysis Soil microbiome KEGG pathways Nutrient cycling Soil enzymes
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Preferential Lewis-basic ion pathways for accelerated Zn2+ diffusion and uniform deposition at zinc metal anodes 认领 引用
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作者 Linxia Yu Quan Zong +8 位作者 Xin Li Guoying Wei Qilong Zhang Qiaoling Kang Jingji Zhang Gongxun Bai Shuang Zhou Anqiang Pan Chengbin Jin 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期645-656,I0016,共12页
With advantages of high safety,low cost,and environmental friendliness,aqueous zinc metal batteries(ZMBs)are widely recognized as potential next-generation systems for grid-scale energy storage.However,their widesprea... With advantages of high safety,low cost,and environmental friendliness,aqueous zinc metal batteries(ZMBs)are widely recognized as potential next-generation systems for grid-scale energy storage.However,their widespread application suffers from unstable Zn/electrolyte interfaces induced by uncontrolled Zn2+desolvation,migration,and deposition.Herein,we propose a molecularly engineered interfacial layer,created through a hydrolysis-condensation molecular assembly,that couples hydrophobic exclusion,preferential Zn2+transport pathways,and Lewis-basic coordination centers within a single framework.The strong electronegativity and hydrophobic properties of the macromolecular layer effectively repel anions and exclude free water molecules from the Zn surface,thereby suppressing hydrogen evolution and byproduct accumulation.Meanwhile,the preferential ion channels enriched with Lewisbase sites provide favorable Zn2+coordination environments,accelerate desolvation kinetics,and promote preferential ion migration,ultimately lowering nucleation barriers and homogenizing Zn2+flux.Benefiting from this regulation of interfacial chemistry and transport kinetics,the modified Zn anode achieves dendrite-free and highly reversible Zn plating/stripping,delivering a long cycling lifespan(3600 h at 1 m A cm-2and 1 mAh cm-2),high Coulombic efficiency(99.7%after 1200 cycles),and excellent full-cell capacity retention(95%after 2000 cycles). 展开更多
关键词 Hydrophobicity Preferential ion pathways Lewis-base sites Dendrite-free
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Reversible thermodynamic pathways in shock-compressed liquid nitrogen:Unveiling the role of molecular dissociation in shock cooling and phase transition 认领 引用
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作者 Muhammad Sabeeh Akram Shumail Sattar +5 位作者 Yi-Wen Wei Lei Yang Wen-Shuo Yuan Zhuo-Ning Fan Qi-Jun Liu Fu-Sheng Liu 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2026年第3期107-120,共14页
This study investigates the high-pressure behavior of liquid nitrogen(LN2),under dynamic compression from 19 to 89 GPa and corresponding temperatures from 4000 to 8200 K.Using Doppler velocimetry and multichannel pyro... This study investigates the high-pressure behavior of liquid nitrogen(LN2),under dynamic compression from 19 to 89 GPa and corresponding temperatures from 4000 to 8200 K.Using Doppler velocimetry and multichannel pyrometry,we determine the Hugoniot states,shock temperatures,and emissivity.The application of sequential shocks and subsequent pressure release process lead to significant variations in radiance and radiative temperature,which help to predict the optical transparency at the LN2/LiF interface.Our results indicate the existence of two distinct thermodynamic pathways.In experiments with an initial shock>30 GPa,at the second shock(re-shock),the fluid undergoes shock cooling,which we attribute to the formation of a transient complex molecular state.Further,during pressure release,we observe thermal energy emission,which indicates that decompression primarily governs the phase transitions as well as the reversible thermodynamic pathways.By contrast,LN2 initially shocked to 19 GPa undergoes dissociation upon re-shock,followed by recombination during pressure release,with no evidence of cooling being observed.A comparison of these results suggests that shock cooling consistently appears above 30 GPa and 6500 K.Furthermore,these two regimes are differentiated by their response to pressure release:while both show a decrease in emissivity that reflects restoration of the fluid’s transparency,the magnitudes are dramatically different.A 21%decrease occurs in the shock-cooling regime,compared with a 39%reduction in the dissociation-dominated regime. 展开更多
关键词 reversible thermodynamic pathways doppler velocimetry molecular dissociation shock compressed liquid nitrogen dynamic compression multichannel pyrometrywe pressure release process sequential shocks
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Wide range of potential spillover effects under net-zero emissions pathways for Australia’s land sector:Policy settings for a sustainable transition 认领 引用
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作者 Md Shakil Khan Enayat A.Moallemi +4 位作者 Dhananjay Thiruvady Asef Nazari Raymundo Marcos Martinez Nicholas Van Schoten Brett A.Bryan 《Geography and Sustainability》 CSCD 2026年第3期276-291,共16页
The land sector has significant potential to contribute to net-zero greenhouse gas(GHG)emissions commitments via changes in land-use and management.Land-use change however,can have spillover effects for a range of oth... The land sector has significant potential to contribute to net-zero greenhouse gas(GHG)emissions commitments via changes in land-use and management.Land-use change however,can have spillover effects for a range of other socio-economic and environmental indicators.In this study,we identified net-zero pathways which mitigate trade-offs and capture co-benefits for the Australian land sector using a combination of exploratory scenario analysis and scenario discovery.Using machine learning-based surrogate models trained on the Land-Use Trade-Offs(LUTO)model,we identified many net-zero compliant scenarios at three different estimates of emissions abatement(low,medium,and high)requirement for the land sector and quantified their potential spillover effects.We found that significant land-use change may be required for Australia’s land sector to contribute to net-zero and that this has both trade-offs and co-benefits for economic returns,food production,biodiversity,and water resources.Crucially,the impacts of achieving net-zero on land-use change and spillover effects varied widely with both the level of land sector emissions abatement required and the policy settings within each abatement level.To illustrate,compared to the worst performing Medium abatement level pathway,the best performing pathway achieved 23.04$B yr-1 more in economic returns,produced 28.76$B yr-1 more food/fibre,and generated 23.24%greater biodiversity services,but with a trade-off of 2.82 million ML yr-1 more water use.We outline the specific policy settings required for a sustainable net-zero transition for the land sector(i.e.,which avoid trade-offs and capture co-benefits)for the three abatement levels including carbon pricing,agricultural productivity gains,reduced barriers to adoption,and incentives to support biodiversity.The results illustrate the importance of a portfolio of well-designed,evidence-based policy interventions for supporting a sustainable transition to net-zero emissions. 展开更多
关键词 Net-zero emissions pathways Land-use change Scenario discovery Sustainability transition Trade-offs and co-benefits Spillover effects
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CO2 utilization and fixation in biomass-derived furanics conversion:Thermochemical and electrochemical pathways 认领 引用
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作者 Saeideh Gharouni Fattah Sabah Karimi +5 位作者 Shaoyu Yuan Zheng Li Mohammad Jalal Zohuriaan-Mehr Lu Lin Xianhai Zeng Buxing Han 《Green Energy & Environment》 SCIE EI CAS CSCD 2026年第1期1-22,共22页
Carbon dioxide(CO2)is the main greenhouse gas(GHG)released by human activities.The substitution of fossil resources by biomass as a bio-renewable resource,has significant potential to reduce GHG emissions.The appro... Carbon dioxide(CO2)is the main greenhouse gas(GHG)released by human activities.The substitution of fossil resources by biomass as a bio-renewable resource,has significant potential to reduce GHG emissions.The approach to biomass,as the only true full-scale alternative to fossil resources,is progressing rapidly.Converting biomass into furanic compounds,as versatile platform chemicals for synthesizing a wide range of bio-based products is the cornerstone of sustainable technologies.The extensive body of this review combines the biomass valorization to furanic compounds by CO2utilization and furanic compounds conversion by CO2fixation.These processes can be strategically applied through both‘thermochemical’and‘electrochemical’pathways,by utilizing CO2from the atmosphere or industrial emission point and returning it to the natural carbon cycle.In the thermochemical pathway CO2acts as a carbon source(carboxylation and polymerization)or active reaction assistant in the biomass conversion(CO2-assisted conversion),without altering its oxidation state,facilitating the synthesis of valuable products and polymers.Conversely,in the electrochemical pathway,CO2can be used as a carbon source(electrocarboxylation)to give the corresponding carboxylic acid,or it can undergo reduction,yielding methanol,carbon monoxide(CO),formic acid,and analogous compounds,while on the other side,furanic compounds undergo oxidation yielding high-value-added chemicals.Finally,potential future research directions are suggested to promote CO2utilization and fixation in the valorization of biomass-derived furanic compounds,and challenges facing further research are highlighted. 展开更多
关键词 CO2utilization and fixation Biomass valorization Furanic compounds Thermochemical and electrochemical pathways Renewable and sustainable resources
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Salivary Biomarkers and Their Link to Oncogenic Signaling Pathways in Oral Squamous Cell Carcinoma:Diagnostic and Translational Perspectives in a Narrative Review 认领 引用
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作者 Wen-Shou Tan Hsuan Kuo +6 位作者 Chang-Ge Jiang Mei-Han Lu Yi-He Lu Yung-Li Wang Ching-Shuen Wang Thi Thuy Tien Vo I-Ta Lee 《Oncology Research》 SCIE 2026年第1期105-120,共16页
This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma(OSCC),a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis.Saliv... This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma(OSCC),a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis.Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes.Various salivary biomarkers,including microRNAs,cytokines,proteins,metabolites,and exosomes,have been linked to oncogenic signaling pathways involved in tumor progression,immune modulation,and therapeutic resistance.Advances in quantitative polymerase chain reaction,mass spectrometry,and next-generation sequencing have enabled comprehensive biomarker profiling,while point-of-care detection systems and saliva-based omics platforms are accelerating clinical translation.Remaining challenges include variability in salivary composition,lack of standardized collection protocols,and insufficient validation across large patient cohorts.This review highlights the mechanistic relevance,diagnostic potential,and translational challenges of salivary biomarkers in OSCC. 展开更多
关键词 Oral squamous cell carcinoma(OSCC) salivary biomarkers signaling pathways non-invasive diagnostics narrative review
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Quantum pathways interference in nonadiabatic strong-field ionizations driven by elliptically polarized laser pulses 认领 引用
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作者 Yidian Tian Kunlong Liu Yueming Zhou 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第4期79-87,共9页
Ultrafast phenomena initiated by strong-field ionization are commonly interpreted within classical or semiclassical frameworks based on electron trajectories.In this work,we theoretically investigate the energy-resolv... Ultrafast phenomena initiated by strong-field ionization are commonly interpreted within classical or semiclassical frameworks based on electron trajectories.In this work,we theoretically investigate the energy-resolved photoelectron angular distributions in above-threshold ionization(ATI)induced by elliptically polarized ultraviolet(UV)pulses and unravel the underlying dynamics from the perspective of quantum-pathway interference.By numerically solving the threedimensional time-dependent Schrodinger equation,we extract the contributions of the quantum pathways for an electron transitioning from the ground state to the continuum under pulses with different ellipticities.Our results demonstrate that for close-to-circularly polarized UV pulses,two quantum pathways govern the angular distribution for each ATI peak,and their interference produces a cosinusoidal oscillation in the photoelectron angular distributions,which is distinct from the Gaussian characteristic predicted by the traditional tunneling framework.In particular,the corresponding offset angle is shown to depend on the relative phase between these two dominant channels.As the ellipticity decreases,the increasing number of contributing pathways leads to a multiple-peak structure in the photoelectron angular distribution.The present study provides a quantum-mechanical perspective for understanding the angular streaking of nonadiabatic ionization in rotating fields. 展开更多
关键词 nonadiabatic strong-field ionization elliptically polarized field quantum pathways interference angular offset
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Serpine2-Lrp1 and CD39-A3AR Intercellular Signalling Pathways:Novel Therapeutic Targets for Vascular Dementia 认领 引用
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作者 Xiao-Feng Ran Peter Illes Yong Tang 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第2期481-484,共4页
Recently,Tian et al.published a research paper with significant breakthroughs in Cell[1].The study found that targeting the signalling pathways named Serpine2-lowdensity lipoprotein receptor-related protein 1(Lrp1)and... Recently,Tian et al.published a research paper with significant breakthroughs in Cell[1].The study found that targeting the signalling pathways named Serpine2-lowdensity lipoprotein receptor-related protein 1(Lrp1)and ectonucleoside triphosphate diphosphohydrolase 1(CD39)-adenosine A3receptor(A3AR)is a promising strategy for the treatment of vascular dementia.The Serpine2-Lrp1 signalling pathway primarily exerts its therapeutic effects on myelin regeneration by regulating the differentiation of oligodendrocyte precursor cells.Serpine2 is a secretory serine protease inhibitor regulates proteolytic homeostasis.It may also bind to cell surface receptors such as Lrp1 to directly activate signalling pathways.As a transmembrane glycoprotein receptor,Lrpl mediates the endocytic clearance of ligands. 展开更多
关键词 serpine lrp oligodendrocyte precursor cells targeting signalling pathways vascular dementia myelin regeneration ectonucleoside triphosphate cd ar treatment vascular dementiathe
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Percutaneous vs surgical management of hepatic cystic echinococcosis:A perspective on evolving clinical pathways 认领 引用
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作者 Xin-Ying Zhang Bao-Qi Li +3 位作者 Wen-Na Cao Zi-Li Zhang Qi Xin Ke-Feng Jia 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期1-9,共9页
The management of hepatic cystic echinococcosis continues to evolve,with percutaneous techniques increasingly challenging traditional surgical approaches.The paper from Tahtabasi et al on the recent issue of World Jou... The management of hepatic cystic echinococcosis continues to evolve,with percutaneous techniques increasingly challenging traditional surgical approaches.The paper from Tahtabasi et al on the recent issue of World Journal of Gastroenterology present a large-scale retrospective analysis comparing percutaneous and surgical treatments for liver hydatid cysts with a World Health Organization classification of CE1 and CE3a over a 20-year period.Their study,encompassing 989 patients from an endemic region in Türkiye,provides robust real-world evidence that percutaneous methods offer shorter hospital stays,reduced operative times,and lower risks of intraoperative organ injury,while surgical intervention demonstrates marginal advantages in reducing recollection and anaphylaxis.Importantly,the study identifies cyst volume as a key predictor of cystobiliary fistula development,irrespective of treatment modality.This editorial contextualizes these findings within the broader landscape of hydatid disease management,discusses methodological strengths and limitations,and highlights the need for standardized definitions,randomized trials,and individualized treatment algorithms.We argue that a tailored approach-incorporating cyst characteristics,anatomical location,and patient factors-is essential for optimizing outcomes in patients with this complex parasitic disease. 展开更多
关键词 Cystic echinococcosis Percutaneous treatment Surgical management Clinical pathways Zoonotic disease Echinococcus granulosus Hydatid cyst
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