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Different poisoning behaviors of impurity gases on AB2-type Ti-based hydrogen storage alloys and their mechanisms 认领 引用 被引量：1
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作者 Yongpeng Chen Panpan Zhou +7 位作者 Jiapeng Bi Liuhui Zhu Lingchao Zhang Chengguo Yan Yuxiao Jia Xuezhang Xiao Xinhua Wang Lixin Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第3期350-361,共12页
AB2-type Ti-based hydrogen storage alloys(HSAs)are promising for industrial hydrogen feeding systems due to their moderate operating conditions and high hydrogen storage capacity.However,their practical application... AB2-type Ti-based hydrogen storage alloys(HSAs)are promising for industrial hydrogen feeding systems due to their moderate operating conditions and high hydrogen storage capacity.However,their practical application is hindered by unavoidable impurity gases in hydrogen feedstocks,which significantly impair the performance of HSAs.Furthermore,the absence of clear evaluation criteria for poisoning behaviors and mechanisms hinders efforts to develop effective mitigation strategies.To address this gap,we used calculated surface interaction energy changes(ΔE)and experimental investigations to classify and rank the poisoning potential of impurity gases on a C14 Laves-phase Ti0.86Zr0.15Mn1.5Cr0.07(VFe)0.43 alloy.Impurity gases were classified into two types of weak-adsorption and strong-adsorption impurity gases by comparing theirΔE with that of H2(ΔE_(H2)=-1.6001 eV).AsΔE>ΔE_(H2) ,weak-adsorption impurity gases(Ar,He,CH4,and N2)induce poisoning by forming enriched blocking layers that impede H2 diffusion.This blocking effect can be alleviated under gas flow conditions.AsΔE<ΔE_(H2),strong adsorption gases are further divided into two types based on their reactivity with the alloy.Non-reactive strong-adsorption impurity gases(CO and CO2 )preferentially occupy surface active sites,blocking H2 adsorption and dissociation.In contrast,reactive strong-adsorption impurity gases(such as O2)form dense passivation layers that completely prevent hydrogen ingress.Accordingly,surface modification offers an effective approach to mitigate gas-induced poisoning by altering the interaction mechanism.This study establishes the parameter-based criteria for classifying impurity gas poisoning mechanisms in AB2-type Ti-based HSAs.It provides fundamental insights for guiding the design of poisoning-resistant materials and the development of mitigation strategies. 展开更多
关键词 Ti-based hydrogen storage alloys Impurity gas Surface interaction energy change Poisoning mechanisms
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Successful treatment of a patient with mixed pesticide poisoning caused by lethal-dose emamectin benzoate and chlorfenapyr 认领 引用
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作者 Xueting Cao Yunhan Liu +4 位作者 Gen Ba Ji Wang Haikang Jin Dianxia Lu Jinsong Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第1期89-91,共3页
Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,l... Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,leading to more poisoning incidents.It has a fatality rate as high as 76%after poisoning.[1]Here,we report a successful treatment of a patient with mixed pesticide poisoning caused by lethaldose emamectin benzoate(EB)and chlorfenapyr in the Department of Critical Care Medicine,Yangzhou Hongquan Hospital. 展开更多
关键词 mixed pesticide poisoning fatality rate public health challenge chlorfenapyr emamectin benzoate lethaldose emamectin benzoate eb pesticide poisoning treatment
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Synergistic localized interface engineering alleviating PGM-based catalyst from sulfonate poisoning in fuel cells via balanced adsorption modulation 认领 引用
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作者 Zihou Zhang Yuxiang Wang +5 位作者 Ping Fang Wei Zhao Yucheng Hou Fangce Li Maorong Chai Yujing Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第5期813-821,I0019,共9页
The performance of proton-exchange-membrane fuel cell(PEMFC)is known to be highly restrained by the nano-micro-scale ionomer-catalyst interface structure.The commonly used ionomers in the catalyst layer are functional... The performance of proton-exchange-membrane fuel cell(PEMFC)is known to be highly restrained by the nano-micro-scale ionomer-catalyst interface structure.The commonly used ionomers in the catalyst layer are functionalized by forming a nanoscale network with platinum-group-metal(PGM)based catalyst.The imbalanced binding strengths of sulfonate groups to the PGM surface compared to the carbon support surface lead to the favorable occupation of active sites for oxygen reduction reaction(ORR)and the declining performances in membrane electrode assembly(MEA).In this work,by employing a dual strategy on PGM and carbon support,a catalyst/support design is proposed to significantly reduce the variance in adsorption energies of sulfonate to the PGM and carbon surface.The balanced adsorption of sulfonate groups enables a more uniform distribution of ionomer on the catalyst surface with enhanced catalytic activity.The PtCo/CNH-N catalyst not only achieves a power density far exceeding that of its counterpart in MEA but also exhibits high stability against ionomer poisoning throughout potential cycling.Combining experimental evidence and theoretical calculation,this work corroborates the essential role of balanced binding strengths of sulfonate groups to PGM and carbon surface,and provides insight into the ionomer poisoning issue towards the design of a highly stable catalyst for PEMFC. 展开更多
关键词 Fuel cell N-functional group Oxygen reduction PGM catalyst Ionomer poisoning
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Clearance eff ects of blood purifi cation on chlorfenapyr and tralopyril in chlorfenapyr poisoning patients 认领 引用 被引量：2
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作者 Yu Gong Yanling Dong +7 位作者 Yaqing An Hongxin Zhang Yiqing Sun Yijiao Men Hengbo Gao Dongqi Yao Na Meng Yingping Tian 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第1期65-69,共5页
BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute pois... BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute poisoning.METHODS:This retrospective study included 18 patients with acute oral chlorfenapyr poisoning treated at our department between January 2022 and January 2024.All patients received conventional therapies combined with blood purification,including HP,CRRT,and PE.HP was performed three sessions within the fi rst 24 h,followed by CRRT and PE.Serial blood samples were collected to measure plasma concentrations of chlorfenapyr and tralopyril using gas chromatography/liquid chromatography-mass spectrometry(GC/LC-MS).The toxin-clearance eff ects were assessed using a linear mixed-eff ects(LME)model.RESULTS:The hourly decline rate of the plasma chlorfenapyr concentration(median[IQR])was 8.83%(1.79%)for HP,4.12%(1.26%)for CRRT,and 6.85%(1.44%)for PE.LME analysis showed higher decline rate in the plasma concentration with HP(β=5.00;P<0.001)and PE(β=2.15;P=0.003)compared to CRRT.For tralopyril,the hourly decline rates were 3.04%(0.62%)for HP,1.82%(0.48%)for CRRT,and 3.01%(0.37%)for PE.LME analysis showed that the clearance effects of HP(β=0.027;P<0.001)and PE(β=0.022;P=0.001)were superior to CRRT.Pre-treatment toxin levels and the interval from hospital admission to blood purifi cation showed no signifi cant interaction with clearance outcomes.CONCLUSION:In our study,HP was associated with a higher decline rate in plasma chlorfenapyr concentration compared to CRRT and PE,supporting HP as a preferred early intervention.However,all three methods showed limited effi cacy in reducing tralopyril levels.Further research into the toxicokinetics and mechanisms of chlorfenapyr is warranted to optimize purifi cation strategies. 展开更多
关键词 Chlorfenapyr Tralopyril Poisoning Hemoperfusion Plasma exchange Continuous renal replacement therapy
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Aconitine poisoning after acupuncture and cupping:a case report 认领 引用
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作者 Lei Wu Xingcheng Li +3 位作者 Jialong Chen Congli Yang Fenshuang Zheng Canju Yang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第1期92-94,共3页
Aconitines are a group of highly bioactive and toxic compounds found in aconitum species.[1]It is clinically used to treat rheumatism,rheumatoid arthritis,osteoarthritis,and cancer.[2]In folk medicine,aconitine is oft... Aconitines are a group of highly bioactive and toxic compounds found in aconitum species.[1]It is clinically used to treat rheumatism,rheumatoid arthritis,osteoarthritis,and cancer.[2]In folk medicine,aconitine is often soaked in white wine to make medicinal wine,which is used to treat rheumatism,joint pain,and other diseases.[3]Improper use of aconitine can cause adverse effects in the nervous system and digestive system,as well as cardiovascular dysfunction,especially arrhythmia.[4]Because of its high toxicity when it is improperly handled,aconitine has attracted widespread attention. 展开更多
关键词 treat rheumatismrheumatoid white wine acupuncture cupping case report treat rheumatismjoint poisoning medicinal winewhich
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Acute glufosinate-ammonium poisoning complicated with respiratory depression:a case report 认领 引用
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作者 Sheng Pu Lei Xu +4 位作者 Xingcheng Li Ya Li Wenfang Zhang Fenshuang Zheng Junyue Hu 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第3期293-295,共3页
Glufosinate-ammonium(GLA)is a widely used herbicide.GLA poisoning frequently manifests with neurological symptoms,including impaired consciousness and seizures.[1]At present,there are no treatment guidelines for GLA p... Glufosinate-ammonium(GLA)is a widely used herbicide.GLA poisoning frequently manifests with neurological symptoms,including impaired consciousness and seizures.[1]At present,there are no treatment guidelines for GLA poisoning,and its management relies primarily on clinical experience.Therapeutic strategies emphasize toxin elimination like gastrointestinal decontamination and blood purification.[1]In severe cases complicated by respiratory depression,mechanical ventilation is often required.[1,2]Herein,we report a case of acute GLA poisoning complicated by respiratory depression admitted to the Emergency Department of the Affiliated Hospital of Yunnan University. 展开更多
关键词 gastrointestinal decontamination toxin elimination respiratory depressionmechanical ventilation blood purification acute glufosinate ammonium poisoning impaired consciousness therapeutic strategies respiratory depression
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Inflammatory and metabolic mediators of acute carbon monoxide poisoning:a Mendelian randomization study 认领 引用
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作者 Hongsen Ji Liqiang Zhao +2 位作者 Jingchun Han Wei Li Li Pang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第2期179-183,共5页
Acute carbon monoxide(CO) poisoning constitutes a lethal hazard globally,causing substantial mortality and morbidity worldwide.[1-2] Studies have shown that multiple mechanisms contribute to acute CO poisoning,incl... Acute carbon monoxide(CO) poisoning constitutes a lethal hazard globally,causing substantial mortality and morbidity worldwide.[1-2] Studies have shown that multiple mechanisms contribute to acute CO poisoning,including ischemic-hypoxic injury,reactive oxygen species(ROS) generation and inflammatory responses.[2-5] Furthermore,excessive inflammatory responses can induce adverse metabolic changes.[6-7] Considering these evidence,an interaction may exist between acute CO poisoning and both inflammatory factors and metabolites.However,the mechanisms through which inflammatory factors mediate CO toxicity via metabolic pathways remain largely unexplored. 展开更多
关键词 oxygen species ros ischemic hypoxic injury metabolic changes reactive oxygen species acute carbon monoxide poisoning carbon monoxide co inflammatory factors inflammatory responses
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Robust Federated Learning for Intrusion Detection in Autonomous Vehicles against Poisoning Attacks 认领 引用
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作者 Ulysses Lam Jin-Hee Cho +4 位作者 Hyuk Lim Terrence Moore Frederica Free-Nelson Hyunjae Kang Dan Dongseong Kim 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第6期1594-1610,共17页
Autonomous vehicles are potentially more vulnerable to cyber-attacks compared to traditional humandriven ones,as they employ electronic sensors to enable self-driving.Cybersecurity for autonomous vehicles will be cruc... Autonomous vehicles are potentially more vulnerable to cyber-attacks compared to traditional humandriven ones,as they employ electronic sensors to enable self-driving.Cybersecurity for autonomous vehicles will be crucial in the near future.However,intrusion detection systems(IDSes)for vehicles are still in the early stages.Many IDS models that claim to work for vehicles are actually built with traditional Internet datasets rather than those with real vehicle data,which is impractical in reality.In this paper,IDS models are developed with Federated Learning(FL)with the Car-Hacking and CAN-MIRGU datasets,which are obtained from real vehicles.The FL-based IDS models achieve high attack-detection performance,while each local client retains their privacy by sharing only local model weights rather than local datasets.Training of local models takes an extremely short time and is feasible in practice for vehicles with low computational resources.Furthermore,different poisoning scenarios are performed on local clients to demonstrate the high robustness of FL models.The FL-based IDS models are highly robust against poisoning attacks and maintain high detection accuracy as long as the majority of local clients are not compromised.In this paper,a new study on IDS for autonomous vehicles has been carried out with two novel contributions:FL models built with real vehicular datasets and the robustness of FL models against poisoning attacks.Firstly,new FL-based IDS models are developed for autonomous vehicles with real datasets containing CAN bus messages.In particular,there is no prior work on IDS models built with the new and comprehensive CAN-MIRGU datasets.The IDS models show the advantages of decentralisation,that local clients with limited computational resources can still detect intrusions with high accuracy by sharing the training process with a small amount of local data.The FL models achieve high performance in detecting most attack types,except for suspension attacks,which have distinct characteristics.Secondly,the FL models have also shown strong robustness against data contamination.The models can maintain relatively high performance as long as more than half of the clients or local datasets are not under poisoning attacks.However,this study has included only attack types from the Car-Hacking and CAN-MIRGU datasets,but the performance of FL models for detecting novel attacks is unknown.In reality,attackers can also perform evasion attacks,such as varying time intervals of attack injections,to trick IDS models.Therefore,extracted features of message counts will not provide meaningful information for intrusion detection.For future work,the FL models will be further improved to detect more attack types,including suspension attacks.One potential solution is to extract more meaningful features from the limited information contained in CAN bus messages.To address evasion attacks,defence strategies such as adversarial training should also be included in developing the FL IDS models.In addition,the models will achieve higher robustness against poisoning attacks by using an advanced aggregation algorithm. 展开更多
关键词 Federated learning intrusion detection Controller Area Network(CAN bus) Vehicular Ad-hoc Network(VANET) poisoning attack
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Analysis of emergency adolescent antidepressant poisoning incidence and family psychological environment influencing factors 认领 引用
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作者 Wei Yu Fang Wang 《World Journal of Psychiatry》 SCIE 2026年第4期254-269,共16页
BACKGROUND The increasing prevalence of adolescent depression has led to widespread antidepressant use,with associated risks of intentional and accidental poisoning.Family dysfunction,parental mental health problems,a... BACKGROUND The increasing prevalence of adolescent depression has led to widespread antidepressant use,with associated risks of intentional and accidental poisoning.Family dysfunction,parental mental health problems,and poor family psychological environment are known risk factors for adolescent self-harm behaviors,but their specific role in antidepressant poisoning has not been systematically investigated.AIM To analyze the incidence characteristics of adolescent antidepressant poisoning in emergency departments,explore the influence of family psychological environment on adolescent antidepressant poisoning,and provide scientific evidence for developing effective prevention strategies.METHODS A retrospective study design was employed,collecting data from 250 adolescent patients aged 12-18 years admitted to the emergency department of a hospital from January 2020 to January 2025,including 28 cases of antidepressant poisoning(poisoning group)and 222 cases of non-drug poisoning adolescent patients(normal group).Family psychological environment was assessed using Family Social Climate Questionnaire,Family Adaptability and Cohesion Evaluation Scales-II,Symptom Checklist-90,Egna Minnen Betraffande Uppfostran,Life Events Scale,and Social Support Rating Scale.Adolescent psychosocial factors were evaluated using Center for Epidemiologic Studies Depression Scale,Self-Rating Anxiety Scale,Adolescent Life Events Scale,Interpersonal Reactivity Index,and Coping Style Questionnaire.Statistical analyses included t-tests,χ2 tests,and multivariate logistic regression analysis for influencing factors.RESULTS The incidence of adolescent antidepressant poisoning in emergency departments was 11.2%[95%confidence interval(CI):7.8%-15.8%].Multivariate logistic regression analysis showed that female gender[odds ratio(OR)=2.847,95%CI:1.024-7.913],high Center for Epidemiologic Studies Depression Scale scores(OR=1.124,95%CI:1.062-1.190),low Family Structure Characteristics Questionnaire total scores(OR=0.934,95%CI:0.891-0.979),high parental Symptom Checklist-90 total scores(OR=1.018,95%CI:1.005-1.031),and low Social Support Rating Scale total scores(OR=0.895,95%CI:0.839-0.955)were independent influencing factors for adolescent antidepressant poisoning(all P<0.05).CONCLUSION The incidence of adolescent antidepressant poisoning is relatively high,with female gender,depression severity,family structure instability,parental mental health problems,and lack of social support being important influencing factors.A family-centered multi-level comprehensive prevention and treatment system should be established,strengthening adolescent mental health screening,improving family psychological environment,and enhancing social support levels. 展开更多
关键词 Adolescents Antidepressant drugs Drug poisoning Family psychological environment Influencing factors Emergency medicine
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Emergency Nursing Measures and Effect Analysis for Acute Accidental Poisoning in Children 认领 引用
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作者 JIANG Yuncong QIAN Chunyan HANG Ling 《外文科技期刊数据库（文摘版）医药卫生》 2026年第2期089-093,共5页
Objective To investigate the significance of implementing targeted emergency nursing interventions in pediatric patients with acute accidental poisoning. Methods The study enrolled 38 pediatric patients with acute acc... Objective To investigate the significance of implementing targeted emergency nursing interventions in pediatric patients with acute accidental poisoning. Methods The study enrolled 38 pediatric patients with acute accidental poisoning from our hospital, selected using computerized random number generation between January 2023 and January 2026. According to the random number method, 19 cases were assigned to each group. The control group received conventional emergency nursing care, while the observation group received targeted nursing interventions;differences in nursing outcomes were compared. Results Compared with the control group, the observation group demonstrated superior rescue indicators such as shorter emergency response time and faster disease diagnosis, lower incidence of complications, higher parental health awareness, lower negative emotion scores, and greater nursing satisfaction (P<0.05). Conclusion During rescue treatment for pediatric patients with acute accidental poisoning, the implementation of specialized nursing models should not be overlooked. Targeted nursing interventions significantly reduced diagnosis and recovery times, effectively controlled complications and negative emotions, stabilized patients psychological state during treatment, and enhanced parental understanding and cooperation. Therefore, further exploration is warranted regarding the specific implementation of targeted nursing approaches. 展开更多
关键词 Accidental ingestion Targeted nursing care Emergency treatment Poisoning
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Unraveling the poisoning mechanism of impurity gases on TiFe hydrogen storage alloys 认领 引用 被引量：6
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作者 Hangyan Shi Yingxian Zhang +7 位作者 Zhenglong Li Fan Gao Xinqiang Wang Yaxiong Yang Yanxia Liu Xuezhang Xiao Fang Fang Wen-Gang Cui 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2025年第11期2743-2755,共13页
TiFe alloys are AB-based hydrogen storage materials with unique characteristics and a wide range of applications.However,the presence of impurity gases(such as O2,CO,CO2,and CH4)has a considerable impact on the ... TiFe alloys are AB-based hydrogen storage materials with unique characteristics and a wide range of applications.However,the presence of impurity gases(such as O2,CO,CO2,and CH4)has a considerable impact on the hydrogen storage capacity and kinetics of TiFe alloys,drastically limiting their practical application in hydrogen storage.Consequently,in this study,we investigated the hydrogen absorption kinetics and cycling performance of the TiFe0.9 alloy in the presence of common impurity gases(including CH4,CO,CO2,and O2)and determined the corresponding poisoning mechanisms.Specifically,we found that CH4 did not react with the alloy but acted through physical coverage.In contrast,CO and CO2 occupy the active sites for H2,significantly impeding the dissociation and absorption of H2.In addition,O2 reacts directly with the alloy to form a passivating layer that prevents hydrogen absorption.These findings were fur-ther corroborated by in situ Fourier transform infrared spectrometry(FTIR)and density functional theory(DFT).The relationship between the adsorption energies of the impurity gases and hydrogen obtained through DFT calculations complements the experimental results.Un-derstanding these poisoning behaviors is crucial for designing Ti-based high-entropy hydrogen storage alloy alloys with enhanced resist-ance to poisoning. 展开更多
关键词 hydrogen storage TiFe alloys poisoning resistance surface reconstruction cycling stability
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Focus on the catalysts to resist the phosphate poisoning in high-temperature proton exchange membrane fuel cells 认领 引用 被引量：1
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作者 Liyuan Gong Li Tao +2 位作者 Lei Wang Xian-Zhu Fu Shuangyin Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第1期155-176,共22页
Investigating highly effective electrocatalysts for high-temperature proton exchange membrane fuel cells(HT-PEMFC)requires the resistance to phosphate acid(PA)poisoning at cathodic oxygen reduction reaction(ORR).Recen... Investigating highly effective electrocatalysts for high-temperature proton exchange membrane fuel cells(HT-PEMFC)requires the resistance to phosphate acid(PA)poisoning at cathodic oxygen reduction reaction(ORR).Recent advancements in catalysts have focused on alleviating phosphoric anion adsorption on Pt-based catalysts with modified electronic structure or catalytic interface and developing Fe-N-C based catalysts with immunity of PA poisoning.Fe-N-C-based catalysts have emerged as promising alternatives to Pt-based catalysts,offering significant potential to overcome the characteristic adsorption of phosphate anion on Pt.An overview of these developments provides insights into catalytic mechanisms and facilitates the design of more efficient catalysts.This review begins with an exploration of basic poisoning principles,followed by a critical summary of characterization techniques employed to identified the underlying mechanism of poisoning effect.Attention is then directed to endeavors aimed at enhancing the HT-PEMFC performance by well-designed catalysts.Finally,the opportunities and challenges in developing the anti-PA poisoning strategy and practical HT-PEMFC is discussed.Through these discussions,a comprehensive understanding of PA-poisoning bottlenecks and inspire future research directions is aim to provided. 展开更多
关键词 Fuel cell High-temperature Phosphate acid poisoning Activitydegradation Electrocatalystdesign
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Effect of retinoic acid on delayed encephalopathy after acute carbon monoxide poisoning:Role of the lncRNA SNHG15/LINGO-1/BDNF/TrkB axis 认领 引用 被引量：1
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作者 HUANG Fangling WANG Su’e +2 位作者 PENG Zhengrong HUANG Xu BAI Sufen 《中南大学学报（医学版）》 CAS CSCD 北大核心 2025年第6期955-969,共15页
Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid... Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid(RA)can suppress the neurotoxic effects of CO.This study further explores,in vivo and in vitro,the molecular mechanisms by which RA alleviates CO-induced central nervous system damage.Methods:A cytotoxic model was established using the mouse hippocampal neuronal cell line HT22 and primary oligodendrocytes exposed to CO,and a DEACMP animal model was established in adult Kunming mice.Cell viability and apoptosis of hippocampal neurons and oligodendrocytes were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Annexin V/propidium iodide(PI)double staining.The transcriptional and protein expression of each gene was detected using real time fluorescence quantitative PCR(RT-qPCR)and Western blotting.Long noncoding RNA(lncRNA)SNHG15 and LINGO-1 were knocked down or overexpressed to observe changes in neurons and oligodendrocytes.In DEACMP mice,SNHG15 or LINGO-1 were knocked down to assess changes in central nervous tissue and downstream protein expression.Results:RA at 10 and 20μmol/L significantly reversed CO-induced apoptosis of hippocampal neurons and oligodendrocytes,downregulation of SNHG15 and LINGO-1,and upregulation of brain-derived neurotrophic factor(BDNF)and tyrosine kinase receptor B(TrkB)(all P<0.05).Overexpression of SNHG15 or LINGO-1 weakened the protective effect of RA against CO-induced cytotoxicity(all P<0.05).Knockdown of SNHG15 or LINGO-1 alleviated CO-induced apoptosis of hippocampal neurons and oligodendrocytes and upregulated BDNF and TrkB expression levels(all P<0.05).Experiments in DEACMP model mice showed that knockdown of SNHG15 or LINGO-1 mitigated central nervous system injury in DEACMP(all P<0.05).Conclusion:RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes,thereby reducing central nervous system injury and exerting neuroprotective effects.LncRNA SNHG15 and LINGO-1 are key molecules mediating RA induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway.These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms. 展开更多
关键词 delayed encephalopathy after acute carbon monoxide poisoning apoptosis retinoic acid neuroprotection LINGO-1 lncRNA SNHG15
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Heavy metal challenge in NH3-SCR DeNOx catalysts:Poisoning deactivation mechanisms and enhanced resistance strategies 认领 引用 被引量：2
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作者 Yu Xia Fengyu Gao +6 位作者 Jiajun Wen Tingkai Xiong Honghong Yi Qingjun Yu Shunzheng Zhao Yuansong Zhou Xiaolong Tang 《Green Energy & Environment》 SCIE EI CAS CSCD 2025年第8期1624-1647,共24页
Ammonia selective catalytic reduction(NH3-SCR)is the most widely used technology in thefield of industrialflue gas denitrification.However,the presence of heavy metals influe gas can seriously affect the performance of... Ammonia selective catalytic reduction(NH3-SCR)is the most widely used technology in thefield of industrialflue gas denitrification.However,the presence of heavy metals influe gas can seriously affect the performance of SCR catalysts,leading to their deactivation or even failure.Therefore,it is of great significance to deeply study the poisoning mechanism of SCR catalysts under the action of heavy metals and how to enhance their resistance to poisoning.This article reviews the reaction mechanism of NH3-SCR technology,compares the impact of heavy metals on the activity of different SCR catalysts,and then discusses in detail the poisoning mechanism of SCR catalysts by heavy metals,including pore blockage,reduction of specific surface area,and destruction of active centers caused by heavy metal deposition,all of which jointly lead to the physical or chemical poisoning of the catalyst.Meanwhile,the mechanism of action when multiple toxicants coexist was analyzed.To effectively address these challenges,the article further summarizes various methods to improve the catalyst's resistance to heavy metal poisoning,such as element doping,structural optimization,and carrier addition,which significantly enhance the heavy metal resistance of the catalyst.Finally,the article provides a prospective analysis of the challenges faced by NH3-SCR catalysts in anti-heavy metal poisoning technology,emphasizing the necessity of in-depth research on the poisoning mechanism,exploration of the mechanism of synergistic action of multiple pollutants,development of comprehensive anti-poisoning strategies,and research on catalyst regeneration technology,in order to promote the development of efficient anti-heavy metal poisoning NH3-SCR catalysts. 展开更多
关键词 Selective Catalytic Reduction(SCR) Industrial flue gas denitration Catalyst performance degradation Nitrogen oxides Heavy metal impact Poison resistance
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Risk factors for death in patients with acute diquat poisoning 认领 引用 被引量：1
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作者 Qing Tang Hongxin Wang +5 位作者 Hao Wang Jiaqi Xu Xin Luo Shuxin Hua Lijun Wang Yanfen Chai 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2025年第3期225-230,共6页
BACKGROUND:In recent years,with the ban on paraquat,the use of diquat(DQ)as a substitute has significantly increased,leading to a corresponding increase in DQ poisoning cases.This study aimed to identify relevant risk... BACKGROUND:In recent years,with the ban on paraquat,the use of diquat(DQ)as a substitute has significantly increased,leading to a corresponding increase in DQ poisoning cases.This study aimed to identify relevant risk factors affecting patient prognosis and provide a basis for the assessment of patient prognosis.METHODS:Patients with DQ poisoning were included from September 2020 to December2023,and data were extracted from their electronic medical records on the first day of hospitalization.Least Absolute Shrinkage and Selection Operator(LASSO)regression and binary multivariate logistic regression analyses were performed on the collected clinical data to identify risk factors.RESULTS:A total of 117 patients with acute DQ poisoning were included,and were categorized into two groups based on their 28-day outcomes:survival group(n=67)and non-survival group(n=50).There were no statistically significant differences between the two groups in terms of sex,lymphocyte count,platelet-to-lymphocyte ratio,or blood purification rate(P>0.05).The analysis revealed that age(odds ratio[OR]1.094,95%confidence interval[95%CI]1.022–1.171),blood drug concentration(OR 3.659,95%CI1.846–7.252),lactate(OR 1.686,95%CI 1.062–2.678),neutrophil-to-lymphocyte ratio(NLR)(OR 1.101,95%CI 1.017–1.192),albumin(OR 1.275,95%CI 1.107–1.468),and aspartate aminotransferase(AST)(OR 1.027,95%CI 1.005–1.051)were the risk factors for mortality.CONCLUSION:This study identified key risk factors for 28-day mortality in patients with acute DQ poisoning,which may provide valuable guidance for clinical treatment,particularly for emergency physicians. 展开更多
关键词 Acute diquat poisoning Prognosis Risk factor Retrospective study
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Adaptive regulation-based Mutual Information Camouflage Poisoning Attack in Graph Neural Networks 认领 引用 被引量：1
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作者 Jihui Yin Taorui Yang +3 位作者 Yifei Sun Jianzhi Gao Jiangbo Lu Zhi-Hui Zhan 《Journal of Automation and Intelligence》 CSCD 2025年第1期21-28,共8页
Studies show that Graph Neural Networks(GNNs)are susceptible to minor perturbations.Therefore,analyzing adversarial attacks on GNNs is crucial in current research.Previous studies used Generative Adversarial Networks ... Studies show that Graph Neural Networks(GNNs)are susceptible to minor perturbations.Therefore,analyzing adversarial attacks on GNNs is crucial in current research.Previous studies used Generative Adversarial Networks to generate a set of fake nodes,injecting them into a clean GNNs to poison the graph structure and evaluate the robustness of GNNs.In the attack process,the computation of new node connections and the attack loss are independent,which affects the attack on the GNN.To improve this,a Fake Node Camouflage Attack based on Mutual Information(FNCAMI)algorithm is proposed.By incorporating Mutual Information(MI)loss,the distribution of nodes injected into the GNNs become more similar to the original nodes,achieving better attack results.Since the loss ratios of GNNs and MI affect performance,we also design an adaptive weighting method.By adjusting the loss weights in real-time through rate changes,larger loss values are obtained,eliminating local optima.The feasibility,effectiveness,and stealthiness of this algorithm are validated on four real datasets.Additionally,we use both global and targeted attacks to test the algorithm’s performance.Comparisons with baseline attack algorithms and ablation experiments demonstrate the efficiency of the FNCAMI algorithm. 展开更多
关键词 Mutual information Adaptive weighting Poisoning attack Graph neural networks
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An unusual case of airway edema and encephalopathy:imidacloprid poisoning 认领 引用
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作者 Manju Mathew Shalini.M.Nair +1 位作者 Nishant G Ninu Rose Paul 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2025年第3期286-288,共3页
Imidacloprid,a neonicotinoid insecticide,is widelyused in agriculture as a safer alternative to highly toxicorganophosphates.It targets nicotinic acetylcholinereceptors in pests and is generally low in toxicity tohuma... Imidacloprid,a neonicotinoid insecticide,is widelyused in agriculture as a safer alternative to highly toxicorganophosphates.It targets nicotinic acetylcholinereceptors in pests and is generally low in toxicity tohumans.However,large ingestions can cause severe,life-threatening complications,with no establishedtreatment protocols.Though rarely fatal,imidaclopridpoisoning is increasingly reported in agricultural regions,particularly in Southeast Asia,with most cases involvingsuicide attempts. 展开更多
关键词 airway edema highly toxicorganophosphatesit poisoning encephalopathy neonicotinoid neonicotinoid insecticideis nicotinic acetylcholinereceptors insecticide
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Hydrothermal aging alleviates hydrocarbon poisoning effects on high-silica Cu-SSZ-16 catalysts for NH3-SCR 认领 引用
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作者 Huan Zhou Jianqi Liu +3 位作者 Yan Zhang Shichao Han Jinpeng Du Wenpo Shan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第12期13-23,共11页
Hydrocarbons(HCs)exert toxic effects on the activity of Cu-based zeolite catalysts for NH3-SCR on diesel vehicles.This study inve stigated the hydrocarbon resistance of both fresh and hydrothermally aged high-silic... Hydrocarbons(HCs)exert toxic effects on the activity of Cu-based zeolite catalysts for NH3-SCR on diesel vehicles.This study inve stigated the hydrocarbon resistance of both fresh and hydrothermally aged high-silica Cu-SSZ-16 catalysts.It was found that low-temperature activity of Cu-SSZ-16 catalyst decreased after C3H6 poisoning,which was mainly due to the blockage of pore channels and the coverage of Cu active sites as well as acid sites by the formation of carbon deposits.Additionally,[Cu(OH)]+-Z was proposed to be more easily affected by C3H6 poisoning than Cu2+-2Z.Hydrothermally aged Cu-SSZ-16 presented better C3H6 resistance than the fresh catalyst since less carbon deposits were accumulated and[Cu(OH)]+-Z species were partially transformed to more-stable Cu2+-2Z in the aged sample.This was probably because of the reduction of acid sites and the formation of CuOx,which enhanced the oxidation of C3H6,thereby inhibiting the formation of carbon deposits.In addition,the coverage of the active Cu species also influenced the adsorption and oxidation of NO,causing a decrease in low-temperature activity.Thus,the low-temperature activity could be fully recovered by hydrothermal treatment at 500℃due to the removal of carbon deposits and recovery of Cu active sites as well as acid sites.In summary,high-silica CuSSZ-16,with high resistance to HCs and excellent hydrothermal stability,is a competitive candidate as a catalyst for the NH3-SCR reaction in practical application. 展开更多
关键词 Hydrocarbon poisoning Hydrothermal aging Cu-SSZ-16 NH3-SCR Diesel exhaust
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Ventricular aneurysm formation after successful intensive hemoperfusion in chlorfenapyr poisoning: a case report 认领 引用
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作者 Ruiqiao Zhao Cuifei Luo +1 位作者 Ping Wang Yuanqiang Lu 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2025年第5期511-513,共3页
Chlorfenapyr poisoning is associated with high mortality due to the absence of evidence-based treatment strategies or specific antidotes.[1,2]Chlorfenapyr is a novel N-substituted halogenated pyrrole pro-insecticide.T... Chlorfenapyr poisoning is associated with high mortality due to the absence of evidence-based treatment strategies or specific antidotes.[1,2]Chlorfenapyr is a novel N-substituted halogenated pyrrole pro-insecticide.The active metabolite of tralopyril(a metabolite of chlorfenapyr)can uncouple oxidative phosphorylation and impair adenosine triphosphate(ATP)production.[3]Blood purification techniques,including hemoperfusion(HP),may facilitate tralopyril clearance.[4,5]Here,we present a case of severe chlorfenapyr poisoning that was treated with intensive HP.H owever,during follow-up,we unexpectedly found a ventricular aneurysm in the left ventricle that was not fully explained by coronary artery lesions. 展开更多
关键词 severe chlorfenap tralopyril uncouple oxidative phosphorylation purification techniquesincluding ventricular aneurysm active metabolite chlorfenapyr poisoning hemoperfusion
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Clinical characteristics of botulinum toxin poisoning following cosmetic injections 认领 引用
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作者 Jiujiu Gui Zhi Li +4 位作者 Shuhao Ye Yuheng Shi Yahui Tang Zhongqiu Lu Aifang Sun 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2025年第5期491-493,共3页
Botulinum toxin,a protein exotoxin secreted by Clostridium botulinum,binds to peripheral nerve terminals,inhibits acetylcholine release,and leads to flaccid muscle paralysis.[1]Botox(onabotulinum toxin A)was approved ... Botulinum toxin,a protein exotoxin secreted by Clostridium botulinum,binds to peripheral nerve terminals,inhibits acetylcholine release,and leads to flaccid muscle paralysis.[1]Botox(onabotulinum toxin A)was approved by the Food and Drug Administration(FDA)for cosmetic and therapeutic indications in 2002,and its global use has increased substantially.[2]However,some unlicensed botulinum toxin products may cause iatrogenic botulism.[3]Early diagnosis remains challenging owing to non-specific clinical features and the lack of diagnostic biomarkers,often delaying the timely administration of antitoxin.[4]This study reviewed recent cases of botulism in our center and summarized their clinical presentations,symptoms,and outcomes. 展开更多
关键词 clostridium botulinumbinds protein exotoxin botulinum toxin flaccid muscle paralysis botox onabotulinum food drug administration fda iatrogenic botulism early botulinum toxina botulinum toxin poisoning
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