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Determination of tenuifolin in Polygalae Radix from different regions by RF-HPCE 认领 引用 被引量：1
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作者 郝增燕 王洁 +1 位作者 张一鸣 陈安家 《Journal of Chinese Pharmaceutical Sciences》 CAS 2011年第4期342-346,共5页
A simple,low-cost and effective reverse flow-high performance capillary electrophoresis（RF-HPCE）method was developed for the separation and determination of tenuifolin in Polygalae Radix.Through optimization of sepa... A simple,low-cost and effective reverse flow-high performance capillary electrophoresis（RF-HPCE）method was developed for the separation and determination of tenuifolin in Polygalae Radix.Through optimization of separation conditions, a buffer of 50 mmol/L borax containing methanol（65：35,v/v）was selected for the separation of analytes.Regression equation revealed good linear relationship between peak area and concentration of the analyte in the range of 0.0563-0.9000 mg/mL （r=0.9988）.The recoveries ranged from 99.50%-104.7%.The results indicated that this method is simple,rapid and accurate. It can be used for the quality control of Polygalae Radix. 展开更多
关键词 RF-HPCE Tenuifolin Polygalae Radix
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Antidepressant effects of Yuanzhi (Polygalae Radix) extract on chronic unpredictable mild stress-induced depression in rats: modulation of the NLRP3 inflammasome and NF-κB pathway 认领 引用 被引量：8
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作者 CHEN Yuzhen ZHAO Yongzhi +4 位作者 ZHANG Yiwen CHEN Fang Iqbal Choudhary Muhammad LIU Xinmin JIANG Ning 《Digital Chinese Medicine》 CAS CSCD 2024年第2期184-194,共11页
Objective To investigate the antidepressant effects of Yuanzhi(Polygalae Radix;PR)aqueous extract on chronic unpredictable mild stress(CUMS)-induced depression rat models and the underlying mechanisms.Methods A total ... Objective To investigate the antidepressant effects of Yuanzhi(Polygalae Radix;PR)aqueous extract on chronic unpredictable mild stress(CUMS)-induced depression rat models and the underlying mechanisms.Methods A total of 40 male Sprague Dawley(SD)rats were randomly divided into control;model;low dose of PR(PR-L;0.5 g/kg);high dose of PR(PR-H;1 g/kg);and fluoxetine(10 mg/kg)groups;with 8 rats in each group.Except for the rats in control group;those in the other four groups underwent CUMS-induced depression modeling.PR and fluoxetine were administered intragastrically once daily;30 min prior to the CUMS procedure;for 14 consecu-tive days until the behavioral tests were performed.After CUMS modeling;the sucrose prefer-ence test(SPT);open field test(OFT);novelty-suppressed feeding test(NSFT);forced swim test(FST);and tail suspension test(TST)were employed to assess the pharmacological ef-fects of PR on the mitigation of depressive-like behaviors in rat models.Additionally;the en-zyme-linked immunosorbent assay(ELISA)was utilized to quantify the serum levels of tumor necrosis factor(TNF)-α;interleukin(IL)-6;and IL-1βin the rats.Western blot analysis was al-so conducted to evaluate the protein expression levels of nuclear factor kappa-B(NF-κB);in-ducible nitric oxide synthase(iNOS);cyclooxygenase-2(COX-2);nucleotide-binding oligomerization domain(NOD)-like receptor family pyrin domain containing 3(NLRP3);apoptosis-associated speck-like protein containing caspase recruitment domain(ASC);and caspase-1 in the hippocampal tissues of the rats.Immunofluorescence staining was per-formed to observe the morphological changes in ionized calcium-binding adapter molecule 1 positive(Iba-1+)cells in the dentate gyrus(DG)of rats with CUMS-induced depression.Results(i)Treatment with PR-H and fluoxetine resulted in significant enhancements in both the total distance and time the rats moved during tests(P<0.01 and P<0.05;respectively).Post-administration of PR-H and fluoxetine also led to statistically significant increase in su-crose preference among rats(P<0.05).Besides;PR-L;PR-H;and fluoxetine treatment markedly decreased the latency of ingestion(P<0.05;P<0.05;and P<0.01;respectively).As observed from the FST;PR-L;PR-H;and fluoxetine presented antidepressant effects on rats with CUMS-induced depression;leading to the reduction in time of their immobility(P<0.05;P<0.01;and P<0.01;respectively).The results of TST indicated reduced immobility time in rats receiving PR-H and fluoxetine treatment as well(P<0.01).(ii)Rats in model group showed an increase in the levels of Iba-1+microglia in their left and right brains in compari-son with control group(P<0.01).However;such increase was negated post PR treatment(P<0.01).Treatment with PR-L;PR-H;and fluoxetine considerably reduced the levels of inflam-matory factors(TNF-α;IL-1β;and IL-6;P<0.01).In addition;treatment of PR-L and PR-H ef-fectively counteracted the elevated levels of NLRP3;ASC;and caspase-1;and markedly down-regulated the expression levels of phosphorylated p65(p-p65);COX-2;and iNOS in rats’hip-pocampus(P<0.01).Conclusion Collectively;these findings indicate that PR exerts an antidepressant effect on rats with CUMS-induced depression partially through the modulation of the NLRP3 and NF-κB signaling pathways. 展开更多
关键词 Depression Yuanzhi(Polygalae Radix) Chronic unpredictable mild stress(CUMS) Proinflammatory cytokine Neuroinflammatory
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Gas chromatography-mass spectrometry analysis on compounds in volatile oils extracted from Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) by supercritical CO_2 认领 引用 被引量：5
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作者 Yingli Wang Liping Chang +2 位作者 Xiaoguang Zhao Xianbin Meng Yaming Liu 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2012年第3期459-464,共6页
OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercriti... OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercritical fluid extraction(SFE) with CO 2,and the constituents of the volatile oil extracts were analyzed by gas chromatography-mass spectrometry(GC-MS).The relative content of each component was calculated using peak area normalization.RESULTS:The optimized SFE conditions were 45 MPa at 35℃ for 2 h.Twenty-four compounds were identified in the extract from the Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) mixture,and six of these had relative contents >1.These compounds were 1,2-dimethoxy-4-(2-propenyl)-benzene;1,2,3-trimethoxy-5-(2-propenyl)-benzene;β-asarone;(Z,Z) 9,12-octadecadienoic acid;(Z) 6-octadecenoic acid;and ethyl oleate.Combination of the herbs increased the number of pharmacologically active substances in the extract and decreased the number of compounds with one benzene ring compared with the extracts from the individual herbs.CONCLUSION:These results indicate there is a synergistic relationship among the compounds in these herbs. 展开更多
关键词 Gas chromatography-mass spectrometry Radix polygalae Acorus tatarinowii Chromatography,Supercritical fluid
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Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-Synuclein and Huntingtin in PC-12 cells 认领 引用
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作者 An-guo WU Betty Yuen-Kwan LAW +1 位作者 Jian-min WU Da-lian QIN 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2017年第10期1003-1004,共2页
OBJECTIVE To investigate the autophagic effect of the compounds from the Chinese medicinal herbs,Radix polygalae as a potential neuroprotective agent that enhances the clearance of mutant Huntingtin andα-synuclein in... OBJECTIVE To investigate the autophagic effect of the compounds from the Chinese medicinal herbs,Radix polygalae as a potential neuroprotective agent that enhances the clearance of mutant Huntingtin andα-synuclein in PC-12 cells.METHODS Radix polygalae was extracted with 75%ethanol using refluxing method,and its quality was assayed by UHPLC-TOF-MS.The autophagic effect of Radix polygalae extract,and its major components including polygalacic acid,senegenin and onjisaponin B were investigated using the green fluorescent protein-light chain 3(GFP-LC3)autophagy detection and Western blot platforms for detecting the autophagic markers,GFP-LC3 puncta formation and LC3Ⅱ expression.The degradation of A53Tα-synuclein and the inhibition of α-synuclein oligo merization related to the Parkinson disease were assayed using Western blot and flow cytometer analysis,respectively.While the cytotoxicity and the degradation of the mutant Huntingtin associated with the Huntingtin disease were investigated using MTT method and flow cytometer analysis.RESULTS Radix polygalae ethanol extract and onjisaponin B improved the GFP-LC3 puncta formation and expression of LC3Ⅱ with time and dose manner,and this induction was activated via AMPK-m TOR and Atg 7 gene pathway.Furthermore,the clearance ofα-synuclein and mutant Huntingtin was enhanced via autophagy induction with the treatment of Radix polygalae ethanol extract and onjisaponin B.CONCLUSION Findings in the current study provide detailed insights into the protective mechanism of a novel autophagy inducer,onjisaponin B,which is valuable for further investigation as a new candidate agent for modulating neurodegenerative disorders through the reduction of toxicity and clearance of mutant proteins in the cellular level. 展开更多
关键词 autophagy Radix polygalae onjisaponin B AMPK mTOR α-synuclein Huntingtin PC-12
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A systematic review on the neuropharmacological activities of Oligosaccharide ester in Polygalae Radix 认领 引用
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作者 Jie Zhang Chuanxin Liu +3 位作者 Yulu Liang Yihong Li Chenning Zhang Jianmei Huang 《TMR Modern Herbal Medicine》 CAS 2021年第1期53-62,共10页
Polygalae Radix,which has a long history of medical use in traditional Chinese medicine,is multifunctional such as tranquilize mind,relieve swelling and remove phlegm.It has been demonstrated that Polygalae Radix olig... Polygalae Radix,which has a long history of medical use in traditional Chinese medicine,is multifunctional such as tranquilize mind,relieve swelling and remove phlegm.It has been demonstrated that Polygalae Radix oligosaccharide ester is the main active component which excutes the neuropharmacological activities like antidepression,anti-dementia and neuroprotection.In this review,the chemical structure,pharmacology,pharmacokinetics and processing mechanism of Polygalae Radix oligosaccharide ester are summarized so as to provide reference for its further development and utilization. 展开更多
关键词 Polygala Radix Oligosaccharide ester Chemical structure Pharmacology Pharmacokinetics Processing
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Advances in the study of senegenin in vascular cognitive impairment 认领 引用
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作者 Yu-Tao Lu Yuan-Yuan Xiang +5 位作者 Zi-Xuan Wang Tian-Rui Yu Ling He Xian-Ming Cao Xiao-Ping Yin Zhi-Ying Chen 《Traditional Medicine Research》 2026年第7期49-59,共11页
Vascular cognitive impairment(VCI)denotes a condition marked by parenchymal brain damage resulting from vascular issues,ultimately culminating in cognitive deterioration that spans from mild cognitive impairment to va... Vascular cognitive impairment(VCI)denotes a condition marked by parenchymal brain damage resulting from vascular issues,ultimately culminating in cognitive deterioration that spans from mild cognitive impairment to vascular dementia.Senegenin is a saponin extract obtained from Polygala tenuifolia,a traditional Chinese medicinal herb known for its significant neuroprotective properties.The review analyzes the impact of senegenin on VCI from the viewpoints of traditional Chinese medicine(TCM)and contemporary medical practices.From the standpoint of TCM,we examine three notable traditional Chinese medicine formulations:Kaixin San,Dingzhi Xiaowan,and Smart Soup.We extensively examine the neuroprotective effects,antioxidant capabilities,and anti-inflammatory actions of senegenin from a contemporary medical standpoint.Additionally,we perform a retrospective review of the extraction and formulation techniques of senegenin.The aim of this review is to summarize the particular mechanisms of senegenin’s multi-targeting and to offer novel insights into clinical therapy strategies for VCI. 展开更多
关键词 Senegenin vascular cognitive impairment vascular dementia Polygala tenuifolia traditional Chinese medicine modern medicine
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Quasi-targeted metabolomics analysis reveals linkage between chemical composition and different post-harvest processing methods of Polygala tenuifolia 认领 引用
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作者 Shuai Liu Jing Liu +7 位作者 Jingjing Li Zongren Xu Kun Lei Jingjing Zhang Yamei Gao Zongsuo Liang Yang Liu Hong Zhang 《Medicinal Plant Biology》 2025年第1期47-60,共14页
The dried root bark of Polygala tenuifolia is widely recognized in traditional Chinese medicine(TCM)for its role in promoting cerebral tranquility.However,conventional post-harvest processing methods present challenge... The dried root bark of Polygala tenuifolia is widely recognized in traditional Chinese medicine(TCM)for its role in promoting cerebral tranquility.However,conventional post-harvest processing methods present challenges in maintaining consistent quality,prompting increased interest in developing improved processing techniques.This study systematically evaluates the impact of three common post-harvest processing methods on the quality of P.tenuifolia.Concentrations of three key bioactive components,tenuifolin(TF),3,6-disinapoyl sucrose,and polygalaxanthone III,designated as quality markers in the Chinese Pharmacopoeia(2020),were used as analytical indicators.Correlation analysis indicated that separating phloem and xylem water content did not significantly affect the levels of these active compounds in the final product.However,both rehydration and prolonged storage of fresh roots compromised quality:rehydration accelerated the degradation of 3,6-disinapoyl sucrose,while extended storage led to a reduction in TF content.Quasi-targeted metabolomics further revealed significant processing-dependent shifts in the metabolic profile.Fresh-cut samples were enriched in neuroactive primary metabolites such as L-theanine andγ-aminobutyric acid,suggesting a pharmacological basis for the herb's tranquilizing effects.Additionally,the three processing methods differentially affected the biosynthesis of phenylpropanoid compounds:upstream intermediates accumulated in fresh-stored samples,whereas downstream metabolites were more prevalent in samples processed by the other two methods.In conclusion,this study provides a comprehensive comparison of three post-harvest techniques,highlights the advantages of fresh-cut P.tenuifolia,and offers valuable insights for optimizing quality control(QC)and therapeutic efficacy in future research. 展开更多
关键词 dried root bark traditional chinese medicine tcm metabolomics post harvest processing promoting cerebral tranquilityhoweverconventional quality markers polygala tenuifolia processing methods
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药用植物远志糖苷B对力竭运动诱导的学习记忆障碍及其机制研究 认领 引用 被引量：1
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作者 弓剑 《分子植物育种》 CAS 北大核心 2025年第16期5538-5545,共8页
远志(Polygala tenuifolia Willd.)为传统中药材,具有“安神益智”之功效。远志糖苷B(tenuifoliside B,TB)是从其根部提取的蔗糖酯类活性成分,具潜在认知保护作用,但其在运动性认知障碍中的作用尚不明确。本研究旨在探讨TB对力竭运动诱... 远志(Polygala tenuifolia Willd.)为传统中药材,具有“安神益智”之功效。远志糖苷B(tenuifoliside B,TB)是从其根部提取的蔗糖酯类活性成分,具潜在认知保护作用,但其在运动性认知障碍中的作用尚不明确。本研究旨在探讨TB对力竭运动诱导大鼠学习记忆障碍的干预效应及其作用机制。实验采用28 d灌胃干预(12.5,25,50 mg·kg-1·d-1),通过Morris水迷宫评估学习记忆能力;免疫荧光染色检测海马Bcl-2与Bax表达,评估细胞凋亡;检测ROS、MDA、GSH水平反映氧化应激状态;ELISA法测定IL-6、TNF-α、IL-1β含量评估炎症反应;RT-qPCR与Western blotting分别分析PSD-95、Synapsin-1基因表达与Akt/CREB/BDNF通路活化情况。结果显示,TB显著改善大鼠认知能力,调节Bcl-2/Bax平衡,增强突触可塑性,抑制氧化应激与炎症,并上调PI3K、Akt、CREB磷酸化及BDNF表达(P<0.05)。综上,远志糖苷B通过多靶点机制改善力竭运动诱导的认知障碍,具有良好的神经保护潜力。 展开更多
关键词 远志(Polygala tenuifolia Willd.) 远志糖苷B 学习记忆障碍 Akt/CREB/BDNF通路 突触可塑性
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Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation 认领 引用 被引量：15
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作者 Na Wang Yong-ming Jia +5 位作者 Bo Zhang Di Xue Maharjan Reeju Yan Li Shu-ming Huang Xue-wei Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第4期654-659,共6页
Kai Xin San is a Chinese herbal formula composed of Radix Ginseng, Poria, Radix Polygalae and Acorus Tatarinowii Rhizome. It has been used in China for many years for treating amnesia. Kai Xin San ameliorates amyloid-... Kai Xin San is a Chinese herbal formula composed of Radix Ginseng, Poria, Radix Polygalae and Acorus Tatarinowii Rhizome. It has been used in China for many years for treating amnesia. Kai Xin San ameliorates amyloid-β （Aβ） induced cognitive dysfunction and is neuroprotective in vivo, but its precise mechanism remains unclear. Expression of insulin-degrading enzyme （IDE）, which degrades Aβ, is strongly correlated with cognitive function. Here, we injected rats with exogenous Aβ42 （200 μM, 5 μL） into the hippocampus and subsequently administered Kai Xin San （0.54 or 1.08 g/kg/d） intragastrically for 21 consecutive days. Hematoxylin eosin and Nissl staining revealed that Kai Xin San protected neurons against Aβ-induced damage. Furthermore, enzyme linked immunosorbent assay, western blot and polymerase chain reaction results showed that Kai Xin San decreased Aβ42 protein levels and increased expression of IDE protein, but not mRNA, in the hippocampus. Our findings reveal that Kai Xin San facilitates hippocampal Aβ degradation and increases IDE expression, which leads, at least in part, to the alleviation of hippocampal neuron injury in rats. 展开更多
关键词 nerve regeneration neurodegeneration traditional Chinese medicine Kai Xin San insulin-degrading enzyme amyloid-β Alzheimer＇sdisease Chinese herbal compound Aβ-degrading enzymes neurons Radix Ginseng Radix Polygalae Acorus Tatarinowii Rhizoma neuralregeneration
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Research Progress of the Liver–Brain Cotreatment of Depression with Supplemented Danzhi Xiaoyao Powder 认领 引用 被引量：2
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作者 Yajing Li Baoying Wang +2 位作者 Yucheng Li Ming Bai Erping Xu 《Chinese Medicine and Natural Products》 CAS 2022年第3期113-119,共7页
Traditional Chinese medicine(TCM)has unique advantages in preventing and treating depression based on holistic concepts and syndrome differentiation and treatment.Liver depression and spleen deficiency are the main sy... Traditional Chinese medicine(TCM)has unique advantages in preventing and treating depression based on holistic concepts and syndrome differentiation and treatment.Liver depression and spleen deficiency are the main syndrome of depression.Danzhi Xiaoyao powder has the efficacy of soothing the liver and relieving depression,nourishing blood,and strengthening spleen.Present studies have proven that it has antidepressant efficacy for the syndrome of liver depression and spleen deficiency.The basic research on pharmacodynamic substances has found that the main active ingredients of Danzhi Xiaoyao powder in the treatment of depression include bupleurum saponin,paeonol,gardenoside,angelica polysaccharide,sulfate polysaccharide,paeoniflorin,albiflorin,atractylone,etc.In clinical practice,Danzhi Xiaoyao powder is often modified to make it more suitable according to the characteristics of pathogenesis and changes in the disease condition.Our research group has found that“brain and spirit failure and liver failing to disperse”are the main pathogenesis of depression.Based on the theory of“liver–brain cotreatment,”the treatment principle of“dispersing the liver and relieving depression,strengthening brain and benefiting intelligence”was put forward.On the basis of Danzhi Xiaoyao powder,Shichangpu(Acori Tatarinowii Rhizoma)was added to enlighten the mind and Yuanzhi(Polygalae Radix)to calm the mind and benefit intelligence.The modified Danzhi Xiaoyao powder was formulated,and its clinical effects on depression were remarkable.Animal experiments also confirmed that modified Danzhi Xiaoyao powder can significantly improve the depression-like behavior of depression model rats and the mechanism may be related to the regulation of the hypothalamic–pituitary–adrenal axis,the increase of the content of 5-hydroxytryptamine,and norepinephrine,which provides a reference for the further promotion of the clinical application of modified Danzhi Xiaoyao powder in the treatment of depression. 展开更多
关键词 depression Supplemented Danzhi Xiaoyao powder liver–brain cotreatment Shichangpu(Acori Tatarinowii Rhizoma) Yuanzhi(Polygalae Radix)
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Isolation of flavonoids from the aerial parts of Polygala tenuifolia Willd.and their antioxidant activities 认领 引用 被引量：23
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作者 史天星 李宇光 +1 位作者 姜勇 屠鹏飞 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2013年第1期36-39,共4页
The aim of this study was to isolate the chemical constituents of the aerial parts of Polygala tenuifolia Willd. and to determine their antioxidant activities. Ten flavonoids were isolated and purified by silica gel, ... The aim of this study was to isolate the chemical constituents of the aerial parts of Polygala tenuifolia Willd. and to determine their antioxidant activities. Ten flavonoids were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and semi-preparative HPLC. Their structures were elucidated by spectroscopic analysis and identified as isorhamnetin-3-O-13-D-glucopyranoside （1）, isorhamnetin-3-O-13-D-galactopyranoside （2）, quercetin-3-O-13-o-glucopyranosyl （1--＊2）-I^-D-galactopyranoside （3）, quercetin-3-O-13-O-glucopyranosyl （1---~2）-13-D-glucopyranoside （4）, linarin （5）, quercetin-3-O- 13-D-glucopyranoside （6）, 5,7-dihydroxy-8-methxoyflavone-7-O-13-o-glucuronoside （7）, isorhamnetin （8）, kaempferol （9） and quercetin （10）. All these compounds were isolated from this plant for the first time, and compounds 1-5 and 7 were isolated from the genus of Polygala for the first time. The antioxidant activities of the isolated compounds were evaluated by DPPH free radical scavenging assay, and compounds 3, 4, 6, 8, 9 and 10 showed potent antioxidant activities. 展开更多
关键词 Polygala Polygala tenuifolia Aerial parts Flavonoids Antioxidant activity
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Chemical investigation of the roots of Polygala sibirica L. 认领 引用 被引量：11
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作者 ZHOU Yu-Hong ZHANG Shui-Ying +3 位作者 GUO Qiang CHAI Xing-Yun JIANG Yong TU Peng-Fei 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第3期225-228,共4页
AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Seph... AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Sephadex LH-20,ODS,semi-preparative HPLC,and preparative TLC.The chemical structures were elucidated based on extensive spectroscopic analysis,including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.RESULTS:A total of sixteen compounds,including five xanthones(5,7–10),five saccharide esters(1,3,4,12,13),two flavonoids(14,16),two triterpenoids(11,15),one phenylpropanoid(6),and one benzophenone glycoside(2) were isolated.Their structures were determined as sibiricose A7(1),sibiriphenone A(2),polygalatenoside A(3),polygalatenoside C(4),lancerin(5),3,4,5-trimethoxycinnamic acid(6),6-hydroxy-1,2,3,7-tetramethoxyxanthone(7),1,3,7-trihydroxy-2-methoxyxanthone(8),onjixanthone II(9),1,2,3,6,7-pentamethoxyxanthone(10),presenegenin(11),3'-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose(12),tenuifoliside C(13),5,3'-dihydroxy-7,4'-dimethoxyflavonol-3-O-β-D-glucopyranoside(14),tenuifolin(15),and rhamnetin 3-O-β-D-glucopyranoside(16).CONCLUSION:Compounds 1 and 2 are two new compounds from P.sibirica. 展开更多
关键词 Polygala sibirica Polygalaceae Sibiricose A7 Sibiriphenone A
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Effects of the crude extract of Polygala tenuifolia Willd on human sperm in vitro 认领 引用 被引量：8
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作者 Yi QIU Lei-guang WANG +5 位作者 Yi-fang JIA Dan-tong YANG Mei-hua ZHANG Yan-ping ZHANG Li-hong ZHANG Ling GAI 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2011年第6期448-454,共7页
The aim of the present study is to analyze sperm membrane changes and the spermicidal effect in treatment with the crude extract from Polygala tenuifo/ia Willd(PTW)in vitro.The root of PTW was extracted in distilled w... The aim of the present study is to analyze sperm membrane changes and the spermicidal effect in treatment with the crude extract from Polygala tenuifo/ia Willd(PTW)in vitro.The root of PTW was extracted in distilled water.Normal human spermatozoa were used to assess the spermicidal activity(Sander-Cramer assay)of the extract from the PTW root.The hypo-osmotic swelling(HOS)test and the eosin Y(EY)staining were used to detect the integrity of sperm membrane and vitality.The sperm chromatin dispersion(SCD)test was performed to determine sperm DNA integrity.N-9 was used as a reference standard and semen added to physiological saline was used as the control.Semen samples were donated by 42 healthy fertile men.The crude extract from the root of PTW could immobilize and kill 100%spermatozoa within 20 s in vitro at the concentrations of 20.0 and 10.0 mg/ml;at the concentration of 5.0 mg/ml,spermatozoa were immobilized in(39.5±3.2)s.In the groups of the crude extract from the root of PTW and N-9 solution the rate of the normal HOS(tails swollen)and the white head(unstained)was 0%,and the rate of the abnormal HOS(tails unswollen)and red head(stained)was 100%.Sperm DNA fragmentation showed no change in exposure to the crude extract from the root of PTW and N-9 solution.The sperm revival test did not show any spermatozoa that recovered their motilities.The rapid spermicidal activity of the crude extract from the root of PTW in vitro may occur by the disruption of the sperm membrane integrity. 展开更多
关键词 Polygala tenuifofia Willd Crude extract Spermicidal effect in vitro Sperm membrane DNA integrity
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Chemical constituents from the roots of Polygala wattersii Hance 认领 引用 被引量：9
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作者 周雨虹 郭强 +1 位作者 姜勇 屠鹏飞 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第10期723-730,共8页
Abstract： To investigate the chemical constituents of the roots of Polygala wattersii Hance, the separation and purification were performed by solvent extraction and repeated column chromatography （CC） on silica ge... Abstract： To investigate the chemical constituents of the roots of Polygala wattersii Hance, the separation and purification were performed by solvent extraction and repeated column chromatography （CC） on silica gel, Sephadex LH-20 and macroporous resin D101, preparative TLC and semi-preparative HPLC. The structures were identified by spectroscopic analysis and comparison of their 1H and 13C NMR data with those reported in literatures. Twenty-three known compounds, including eleven xanthones （1-11）, nine sugar esters （12-20）, two triterpenoid saponins （21 and 22） and one phenylpropanoid （23） were isolated and their structures were identified as 1,3-dihydroxyxanthone （1）, 1-hydroxy-3-methoxyxanthone （2）, 1,3-dihydroxy-2-methoxyxanthone （3）, 1,3,7-trihydroxy-2- methoxyxanthone （4）, 1,3,6-trihydroxy-2,7-dimethoxyxanthone （5）, 1,6,7-trihydroxy-2,3-dimethoxyxanthone （6）, 1,7-dihydroxy- 2,3-methylenedioxyxanthone （7）, 1,7-dimethoxyxanthone （8）, 1,2,3-trimethoxyxanthone （9）, 1-methoxy-2,3-methylenedioxyxanthone （10）, 6-hydroxy-0-methoxy-2,3-methylenedioxyxanthone （11）, 3＇-O-feruloyl-6-O-acetyl sucrose （12）, arillatose B （13）, sibricose A5 （14）, sibricose A6 （15）, 3＇,6-di-O-sinapoyl sucrose （16）, tenufoliside A （17）, 3＇-O-3,4,5-trimethoxycinnamoyl-6-O-p-methoxybenzoyl sucrose （18）, glomeratose A （19）, 1-O-p-coumaroyl-D-glucopyranose （20）, bayogenin-3-O-glucoside （21）, tenufolin （22）, and sinapic acid （23）. Among them, compounds 2 and 12 were obtained from genus Polygala for the first time, and except compound 16, all others were isolated from this species for the first time. 展开更多
关键词 Polygalaceae Polygala wattersii Hance Chemical constituents Xanthones Sugar esters
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Three New Xanthones from Polygala crotalarioides 认领 引用 被引量：5
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作者 Yan HUA Chang Xiang CHEN +2 位作者 Yu Qing LIU Shu Kun CHEN Jun ZHOU 《Chinese Chemical Letters》 SCIE CAS 2006年第6期773-775,共3页
Three new xanthones, 3, 6-dihydroxy-1, 2, 7-trimethoxyxanthone 1, 1, 3, 6-trihydroxy-2, 7, 8-trimethoxyxanthone 2, and 3, 6-dihydroxy-1, 2, 7, 8-tetramethoxyxanthone 3, were isolated from the roots of Polygala crotala... Three new xanthones, 3, 6-dihydroxy-1, 2, 7-trimethoxyxanthone 1, 1, 3, 6-trihydroxy-2, 7, 8-trimethoxyxanthone 2, and 3, 6-dihydroxy-1, 2, 7, 8-tetramethoxyxanthone 3, were isolated from the roots of Polygala crotalarioides. Their structures were elucidated by spectral and chemical methods. 展开更多
关键词 Polygala crotalarioides chemical constituents xanthones.
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Chemical constituents from the roots of Polygala sibirica L. 认领 引用 被引量：6
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作者 周雨虹 姜勇 +2 位作者 温晶 陈玉平 屠鹏飞 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第2期148-152,共5页
To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS column... To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS columns, and semiprep. HPLC. The structures were elucidated by spectral analysis. Twelve known compounds were isolated and identified as tenuifoliside A （1）, tenuifoliside B （2）, glomeratose A （3）, 3＇,6-disinapoyl sucrose （4）, sibiricose A5 （5）, sibiricose A6 （6）, sibiricose A1 （7）, sibiricose A2 （8）, polygalatenoside E （9）, 1-O-L-arabinopyranosyl-O-（6→1）-β-D-glucopyranosyl-salicylate （10）, canthoside A （11）, and methyl- 3,4,5-trimethoxycinnamate （12）. Compound 11 was obtained from genus Polygala for the first time, and compounds 2, 9, 10 and 12 were isolated from this plant for the first time. 展开更多
关键词 Polygalaceae Polygala sibirica L. Chemical constituents
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A new glycoside from Polygala tenuifolia Willd 认领 引用 被引量：3
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作者 Tun Hai Xu Gang Lv +6 位作者 Tong Hua Liu Ya Juan Xu Yun Shan Si Sheng Xu Xie Hong Feng Zhao Dong Han Dong Ming Xu 《Chinese Chemical Letters》 SCIE CAS 2008年第7期817-820,共4页
A new tdterpenoid glycoside, 3-β-O-β-D-glucopyranosyl presenegenin 28-O-α-L-arabipyranosyl（1 → 3）-6-β- xylopyranosyl（1 → 4）-[β-D-apiofuranosyl（1 → 3）]-Ct-L-rhamnopyranosyl（1 → 2）-[α-L-rhamnopyranosyl... A new tdterpenoid glycoside, 3-β-O-β-D-glucopyranosyl presenegenin 28-O-α-L-arabipyranosyl（1 → 3）-6-β- xylopyranosyl（1 → 4）-[β-D-apiofuranosyl（1 → 3）]-Ct-L-rhamnopyranosyl（1 → 2）-[α-L-rhamnopyranosyl（1 → 3）]-β-D-fucopyranosyl ester （1） was isolated from the Polygala tenuifolia Willd., together with two known saponins, including polygalasaponinXXIV （2） and polygalasaponinXXVIII （3）. The structure of new compound was elucidated by spectroscopic methods. 展开更多
关键词 Polygala tenuifolia Willd. Triterpenoid saponin Polygalaceae
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Two New Xanthone Glycosides from Polygala tenuifolia 认领 引用 被引量：8
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作者 YongJIANG PengFeiTU 《Chinese Chemical Letters》 SCIE CAS 2002年第4期335-336,共2页
Two new xanthone glycosides, polygalaxanthone IV and V were isolated from the roots of Polygala tenuifolia Willd. Their structures were established as 6-O-[a-L-rhamnopyranosyl- (12)-b-D-glucopyranosyl]-1-hydroxy-3, 7-... Two new xanthone glycosides, polygalaxanthone IV and V were isolated from the roots of Polygala tenuifolia Willd. Their structures were established as 6-O-[a-L-rhamnopyranosyl- (12)-b-D-glucopyranosyl]-1-hydroxy-3, 7-dimethoxyxanthone (polygalaxanthone IV), and 6-O- [a-L-rhamnopyranosyl-(12)-b-D-glucopyranosyl]-1, 3-dihydroxy-7-methoxyxanthone (polyga- laxanthone V), respectively, on the basis of chemical and spectral evidence. 展开更多
关键词 Polygala tenuifolia xanthone glycosides polygalaxanthone IV and V.
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Two new triterpenoid saponins from Polygala crotalarioides 认领 引用 被引量：2
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作者 Yan Hua Chang Xiang Chen Jun Zhou 《Chinese Chemical Letters》 SCIE CAS 2010年第9期1107-1110,共4页
Two new oleanane-type saponins,crotalarioside A（1） and crotalarioside B（2）,were isolated from the roots of Polygala crotalarioides.Their structures were elucidated on the basis of spectroscopic and chemical evidence.
关键词 Polygala crotalarioides Chemical constituents Oleanane-type saponins
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A new benzophenone C-glycoside from Polygala telephioides Willd 认领 引用 被引量：1
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作者 Ting Jun Ma Xi Cheng Shi Chang Xi Jia 《Chinese Chemical Letters》 SCIE CAS 2010年第5期584-586,共3页
A new benzophenone C-glucoside,3’-C-[4-O-(5-hydroxyferuloyl)-β-D-glucopyranosyl]-2′,4′,6′-trihydroxy-3,4-dimethoxy-benzophenone,named telephenone D,was isolated from the whole plants of Polygala telephioides,and ... A new benzophenone C-glucoside,3’-C-[4-O-(5-hydroxyferuloyl)-β-D-glucopyranosyl]-2′,4′,6′-trihydroxy-3,4-dimethoxy-benzophenone,named telephenone D,was isolated from the whole plants of Polygala telephioides,and its structure was determined by analysis of spectroscopic data. 展开更多
关键词 Polygala telephioides Benzophenone C-glucoside Telephenone D
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