As a distinctive unshaped refractory material used in steelmaking induction furnace linings,significant variations in raw material performance,particularly erosion resistance,have been observed across silica sources f...As a distinctive unshaped refractory material used in steelmaking induction furnace linings,significant variations in raw material performance,particularly erosion resistance,have been observed across silica sources from different regions.To clarify the causes of performance discrepancies and reveal the erosion resistance mechanisms,erosion resistance experiments were conducted on three quartzite raw materials from distinct regions.Furthermore,the enhancement effects of mineralizers on the raw material with the poorest performance were investigated,and the erosion resistance mechanisms of representative raw materials and mineralization effects in silica ramming materials were proposed.The results demonstrated that the presence of dolomite and iron oxide in raw materials is critical for improving the erosion resistance of silica ramming materials.However,the material with 1 wt.%dolomite as a standalone mineralizer exhibited optimal erosion resistance compared to iron oxide composite mineralizers.This improvement is attributed to the formation of uniformly distributed tridymite and an appropriate liquid phase,which mitigates volume expansion effects caused by quartz phase transformation,thereby minimizing aggregate cracking.Additionally,magnesium derived from dolomite plays a specialized role in the operational environment,with the synergistic effects of these two factors collectively enhancing the material’s erosion resistance.展开更多
Metal halide perovskites(MHPs)have been accelerating next generation high performance solar cells due to their high charge carrier transport and optoelectronic properties.However,their thermoelectric properties fall b...Metal halide perovskites(MHPs)have been accelerating next generation high performance solar cells due to their high charge carrier transport and optoelectronic properties.However,their thermoelectric properties fall behind their optoelectronic counterparts,although they have ultralow thermal conductivities and are highly suitable for low grade heat harvesting.A major challenge is how to efficiently dope MHPs in order to achieve high electrical conductivities.As the state-of-the-art MHP for thermoelectric energy conversion,CsSnI3 shows unusual metallic behavior due to the intrinsic Sn vacancies,but it undergoes complex polymorphic phase transitions which hinders its carrier mobility.In this work,we report,for the first time,synthesis of a novel MHP-based thermoelectric device using bulk CsSnI3.This is achieved by leveraging stable polymorphic phase mixing(of orthorhombic and tetragonal phases)and electronic heterostructure.CsSnI3 synthesized by spark-plasma sintering with carbon fiber inclusion shows highly enhanced Seebeck coefficient of~250μV/K,resulting from successful control of the degree of polymorphic phase mixing.The CsSnI3 demonstrates high electrical conductivity of~8400 S/m,attributed to its high carrier mobility.Our approach to control the phase mixing suppresses lattice thermal conductivity to~0.4 W/(m K)through the phonon-boundary scattering.First-principle calculations of the two phases and the phase-interface confirm the strong effect of hybridization and reconstruction of structure at the interface of two phases,which decouples the Seebeck coefficient from electrical conductivity here.The optimized CsSnI3 achieves a power factor of 311μW/(m K2)and ZT of 0.27±0.04,the highest among all reported bulk MHPs.The MHP-based thermoelectric device operates stably across temperature differences of 40 to 260 K,delivering a power density of 3.5 W/m2.This work unlocks the potential of emerging MHPs for thermoelectric devices for low-grade heat harvesting.This could also enable synergistic cooperation between photovoltaic and thermoelectric effects in MHPs for more efficient renewable solar and thermal energy co-harvesting.展开更多
Hexanitrohexaazaisowurtzitane(CL-20)is a high-energy explosive widely used in composite explosives and propellants,but its application is severely limited by thermally inducedε-to-γpolymorphic transition and high so...Hexanitrohexaazaisowurtzitane(CL-20)is a high-energy explosive widely used in composite explosives and propellants,but its application is severely limited by thermally inducedε-to-γpolymorphic transition and high solubility in nitrate ester solvents.The transition reduces energy density and increasing sensitivity,and the solubility causes dissolution-recrystallization defects(e.g.,voids,compositional inhomogeneities)during long-term storage.To address these issues while preserving its high energetic performance,this study developed a polydopamine@polyvinylidene fluoride(PDA@PVDF)dual-coating strategy,fabricating CL-20 composite particles with a core-shell structure.In-situ X-ray diffraction(XRD)results confirmed that theε-to-γphase transition temperature of CL-20 increased from 110℃(pristine CL-20)to 140℃.Meanwhile,the CL-20@PDA@9%PVDF sample exhibited the lowest solubility and the best solvent resistance,and the solubility of CL-20 in nitrate ester solvents was drastically reduced from 0.229 g/100 g–0.026 g/100 g,an 88.6%decrease,effectively enhancing its structural and solvent resistance stability.For energetic performance,when mixed with aluminum powder at a 7:3 mass ratio,the CL-20@PDA@9%PVDF/Al composite achieved a combustion heat of 8275 J/g,8.7%higher than that of the unmodified Al/CL-20 system(7611 J/g).Combustion pressure tests showed that although the modified system exhibited slightly lower initial peak pressure and pressure rise rate due to dilute CL-20 content from inert coatings,it presented a unique"delayed enhancement"effect,with pressure gradually surpassing and ultimately exceeding that of the unmodified system in the middle and late combustion stages,enabling more sustained high-pressure output.This work realizes the synergistic optimization of CL-20's polymorphic/solvent stability and energetic performance,providing a feasible and scalable approach for the practical application of CL-20 in advanced energetic systems.展开更多
Modern malware is increasingly employing polymorphism,packing,and metamorphism to evade traditional signature-based detection.Because of this,there is an urgency to have more reliable classification systems.Visual mal...Modern malware is increasingly employing polymorphism,packing,and metamorphism to evade traditional signature-based detection.Because of this,there is an urgency to have more reliable classification systems.Visual malware analysis,where binaries are converted into grayscale images,has demonstrated potential in revealing structural patterns of malware family classification.However,recent methods mostly rely on single-stream,lightweight Convolutional Neural Networks(CNNs).These models have a major blind spot.The visual representation textures can be heavily obscured without changing the underlying malicious code,causing severe performance drops on newer or even rare malware classes.This paper presents a Hybrid Multi-Modal Deep Learning framework to fix this vulnerability.The proposed dual-stream architecture uses image recognition via EfficientNetB0 alongside metadata analysis using 1D-convolutional byte embeddings.This paper evaluated the framework on the modern MalwareVision-2025 dataset(approximately 125000 samples)and the legacy Malimg dataset(9339 samples).On MalwareVision-2025,the model reached a weighted accuracy of 88.44%and achieved 100%benign recall on the evaluated split.The testing across both datasets shows that combining visual and structural features reduces modality collapse.This creates a much stronger system compared to using either input type on its own.In particular,the hybrid approach improves detection performance on deeply hidden contemporary threats,including the AveMariaRAT and CobaltStrike families.展开更多
Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Ph...Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Phytohemagglutinin-M,Gibco)stimulated blood T lymphocytes by Giemsa trypsin Giemsa banding and Ag-NOR banding on 580 couples with a history of idiopathic recurrent pregnancy loss and 240 couples from the general population.Thirty good chromosomal spreads were captured,karyotyped,and analyzed.The karyotypes were designated using the International System for Human Cytogenomic Nomenclature 2024.Pearson Chi-square test was used to compare the frequency of chromosomal polymorphism variations in the idiopathic recurrent pregnancy loss group with the general population group.Results:A conventional cytogenetic investigation revealed that 45.43%of couples experiencing idiopathic recurrent pregnancy loss presented with various types of chromosomal polymorphic variants,compared to 11.88%in the general population.The overall frequency of these chromosomal polymorphic variants was significantly higher in the idiopathic recurrent pregnancy loss group compared to the general population group(OR 9.97,95%CI 6.99-14.21;P<0.05).Additionally,the prevalence of polymorphic variants was higher among males(49.14%)than females(41.72%)(P=0.01).Conclusions:Chromosomal polymorphic analysis may play a crucial role in the assessment and careful clinical management of cases with idiopathic recurrent pregnancy loss,especially when no other conclusive reasons are identified during the initial evaluation.Therefore,heteromorphism should not be overlooked while investigating the causes of idiopathic recurrent pregnancy loss.展开更多
Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to implementation of precision medicine.This inherited arrhythmia syndrom...Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to implementation of precision medicine.This inherited arrhythmia syndrome induces potentially lethal ventricular arrhythmias by catecholaminergic stress in normally structured hearts and is most commonly due to ryanodine receptor 2(RyR2)mutations in 60%-70%families.Pathophysiology involves gain-of-function mutations forming“leaky”calcium channels with increased sensitivity to catecholaminergic stimulation.Store overload-induced calcium release is a key mechanism whereby mutations reduce thresholds for spontaneous calcium release events.Complex mitochondrial-sarcoplasmic reticulum crosstalk amplifies dysfunction by calciuminduced mitochondrial overload and generation of reactive oxygen species.Modern diagnosis combines next-generation sequencing with functional confirmation using patient-specific induced pluripotent stem cells,allowing for personalized stratification of risk.Male gender,early age of onset,frequent attacks,and central domain mutations are high-risk factors.Exercise testing continues to play a central role in diagnosis and follow-up.Treatment has progressed from empiric β-blocker therapy to mutation-targeted therapy for the condition.β-blockers decrease arrhythmia by 60%-70%,and flecainide adjunct therapy improves success to 80%-90%via direct RyR2 modulation.Carvedilol is more beneficial because of the added alpha-blocking and antioxidant effect.Patients who are refractory are aided by left cardiac sympathetic denervation or implantable cardioverter defibrillators.Upcoming precision medicine includes clustered regularly interspaced short palindromic repeat-associated protein Cas9 gene editing,targeted molecular therapy,and artificial intelligence-based management.RyR2 stabilizers,calmodulin modulators,and mitochondrial protective therapies are promising targeted therapies.Implementation occurs through multidisciplinary care involving genetics,cardiology,and counseling services.Critical challenges are the management of asymptomatic carriers,the definition of exercise limitation,and the validation of biomarkers.Catecholaminergic polymorphic ventricular tachycardia illustrates successful translation of molecular cardiology with a paradigm for inherited arrhythmia syndromes and prevention of sudden cardiac death with mechanistically informed,personalized therapeutic strategies.展开更多
The two-dimensional van der Waals layered semiconductor In2Se3 has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In_(...The two-dimensional van der Waals layered semiconductor In2Se3 has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In2Se3 typically stabilizes in three distinct phases:α-,β′-,and β*-In2Se3,each dominant within specific temperature ranges.Although the crystal structures and ferroelectric properties of these phases have been widely studied,the unambiguous assignment of their in-plane and out-of-plane ferroelectric behaviors,as well as the mechanisms governing their phase transitions,remains a subject of active debate.In this study,we investigate the evolution of atomic and electronic structures in molecular beam epitaxy-grown ultrathin In2Se3 films through correlated microstructural and macroscopic physical property analysis.By employing scanning tunneling microscopy/spectroscopy,temperature-dependent Raman spectroscopy,and piezoresponse force microscopy,we demonstrate a reversible temperature-induced phase transition between the in-plane ferroelectric β*and antiferroelectric β′phases.Furthermore,we confirm robust out-of-plane ferroelectric polarization in the as-grown films and achieve an electric-field-driven transition from the β*to β′phase.Our findings not only advance the fundamental understanding of phase transitions and polarization evolution in two-dimensional semiconductors but also open new avenues for the design of tunable,non-volatile ferroelectric memory devices.展开更多
Generating excessively reactive oxygen species(ROS)within tumor cells is a widely adopted therapeutic strategy.However,single-type ROS exhibit fixed attack sites and mechanisms of action in tumor cells,rendering them ...Generating excessively reactive oxygen species(ROS)within tumor cells is a widely adopted therapeutic strategy.However,single-type ROS exhibit fixed attack sites and mechanisms of action in tumor cells,rendering them susceptible to resistance via cellular repair mechanisms.To overcome this limitation,this study proposes a polymorphic ROS strategy that simultaneously induces multiple types of ROS to enhance the therapeutic efficacy.A nanoplatform named as AuPd@MnxOy/L/DOX(APM@L/D)is developed.AuPd core can catalyze oxygen to generate superoxide anions(O2·-),and the released multivalent manganese ions in tumor can trigger the production of singlet oxygen(1O2)and hydroxyl radicals(·OH).The polymorphic ROS(O2·-,1O2,·OH)with different reactivity,lifetime,and diffusion capacity can achieve multifaceted oxidative damage,significantly improving tumor eradication.Concurrently,photothermal heating and DOX release can enhance catalytic reaction rate and intracellular hydrogen peroxide levels,further amplifying polymorphic ROS generation.Both in vitro and in vivo experiments demonstrate that AP-M@L/D induces significant intracellular oxidative stress and enhances cell-killing efficiency by activating the apoptotic pathway.In summary,the spatiotemporally controllable polymorphic ROS can enhance antitumor efficacy and provide a guidance for ROS therapy.展开更多
An underlying assumption for the size-dependent sex allocation(SDs)hypothesis is that the plasticity of bisexual investments in hermaphrodites would be larger in female than in male allocation,but it has rarely been c...An underlying assumption for the size-dependent sex allocation(SDs)hypothesis is that the plasticity of bisexual investments in hermaphrodites would be larger in female than in male allocation,but it has rarely been critically evaluated.Among five sexual morphs in a sexually polymorphic desert herb Geranium transversale,gynomonoecious individuals were the largest,and males were the smallest,while hermaphroditic and andromonoecious plants and females did not differ significantly in plant size.The total number of flowers increased with plant size in all five sexual morphs;in gynomonoecious and andromonoecious plants this was due to an increase in the number of perfect flowers rather than pistillate or staminate flowers.Flower size increased with plant size in hermaphroditic and gynomonoecious plants(due to an increase in the size of perfect but not of unisexual flowers).The sizes of staminate flowers in andromonoecious and male plants,and pistillate flowers in gynomonoecious plants did not increase with plant size,and pistil mass increased but stamen mass decreased with plant size.The coefficient of variation(CV)in pistil and stamen mass among 21o plants in four of the sexual morphs(excluding female plants)indicated that variation in resource allocation among individuals was higher in female than male functions.Both flower number and flower size generally increased with plant size in G.transversale,supporting the SDS hypothesis.The relatively higher plasticity(CV)in female than male allocation has not been reported before,providing a cue for understanding why the female-biased allocation associated with plant size is popular in flowering plants.展开更多
BACKGROUND Gamma-aminobutyric acid type A receptor has long been acknowledged as a key target in the pathophysiology of epilepsy.The GABRA1 and GABRG2 genes encode theα1 andγ2 subunits of the gamma-aminobutyric acid...BACKGROUND Gamma-aminobutyric acid type A receptor has long been acknowledged as a key target in the pathophysiology of epilepsy.The GABRA1 and GABRG2 genes encode theα1 andγ2 subunits of the gamma-aminobutyric acid type A receptor,a key protein implicated in the development of epilepsy.However,the specific association of the GABRA1 IVS11+15 A>G rs2279020 and GABRG2 G3145A rs211013 polymorphisms with antiepileptic drug resistance has been elucidated in only a limited number of investigations.AIM To elucidate the association between GABRA1 IVS11+15 A>G rs2279020 and GABRG2 G3145A rs211013 gene mutations and drug resistance in epilepsy patients.METHODS A total of 100 epilepsy patients(50 drug responsive and 50 drug resistant subjects)were recruited and rs2279020-and rs211013-polymorphism analyzed by restriction fragment length polymorphism-polymerase chain reaction technique.RESULTS For GABRA1 rs2279020 polymorphism,AG genotype exhibited risk association with an odds ratio of 0.966(95%confidence interval=0.346-2.698)with P value=0.948;however,this association did not achieve statistical significance(P=0.948).Additionally,a higher risk association was identified with the GG genotype,with an odds ratio of 1.808(P=0.382).GABRG2 rs211013 polymorphism revealed no significant association with drug resistance.CONCLUSION The GABRA1 rs2279020 genetic variation is associated with an increased risk for the AG and GG variants,although this association was not statistically significant.Limited investigations have explored the relevance of genetic variations in epilepsy and drug resistance.Longitudinal research is needed to better understand their significance in epilepsy management and to optimize therapeutic strategies.展开更多
For the solid-solid transformation from formⅡto formⅠof isotactic polybutene-1(iPB),the temperature dependence of formⅠnucleation and growth was deemed to control the transformation process.However,the relationship...For the solid-solid transformation from formⅡto formⅠof isotactic polybutene-1(iPB),the temperature dependence of formⅠnucleation and growth was deemed to control the transformation process.However,the relationship between formⅠformation and formⅡdisappearance in the transformation process is not clear.In this work,the spontaneous crystal transformation from formⅡtoⅠof iPB with 81 mol%mmmm sequence concentration is studied firstly by tracking the two processes,the decay of formⅡand the yielding of formⅠin a wide range of temperature spanning from 0℃to 50℃and in a long transformation time ranging from 5 min to 65 days with in situ FTIR and WAXD.Unlike the literature reports,the decay rate of formⅡis firstly found to be lower than the yielding rate of formⅠat all studied temperatures,especially at low transition temperature.This is attributed to the amorphous chains which locate near crystal lamella participating into the nucleation of formⅡ.The regular chain folding and growth of i PB formⅠfrom amorphous chains containing short isotactic sequences also lead to an increase in crystallinity of formⅠcompared with that of initial formⅡcrystallized at 60℃.An increase in the annealing temperature results in decrease in crystallinity and increase in lamellae thickness of i PB formⅠ.展开更多
The translucent endosperm trait in a japonica rice variety'Kantou 194'is controlled by a Wx-mq gene which is allelic to Wx locus by genetic analysis and allelic test.The amylose content analysis showed that an...The translucent endosperm trait in a japonica rice variety'Kantou 194'is controlled by a Wx-mq gene which is allelic to Wx locus by genetic analysis and allelic test.The amylose content analysis showed that an intermediate amylose content between those of glutinous and non-glutinous rice existed in endosperm of homozygous Wx-mq genotype.The slight changes of amylose content in different varieties and F1 grains with an identical Wx-mq genotype might be influenced by dissimilar genetic background.To identify the Wx-mq genotype simply and rapidly,a cleaved amplified polymorphic sequence(CAPS)marker was designed.The result from the molecular detection indicated that it could be used for marker-assisted selection for low amylose content varieties in rice breeding.展开更多
The question of whether an ideal network exists with global scalability in its full life cycle has always been a first-principles problem in the research of network systems and architectures.Thus far,it has not been p...The question of whether an ideal network exists with global scalability in its full life cycle has always been a first-principles problem in the research of network systems and architectures.Thus far,it has not been possible to scientifically practice the design criteria of an ideal network in a unimorphic network system,making it difficult to adapt to known services with clear application scenarios while supporting the ever-growing future services with unexpected characteristics.Here,we theoretically prove that no unimorphic network system can simultaneously meet the scalability requirement in a full cycle in three dimensions—the service-level agreement(S),multiplexity(M),and variousness(V)—which we name as the“impossible SMV triangle”dilemma.It is only by transforming the current network development paradigm that the contradiction between global scalability and a unified network infrastructure can be resolved from the perspectives of thinking,methodology,and practice norms.In this paper,we propose a theoretical framework called the polymorphic network environment(PNE),the first principle of which is to separate or decouple application network systems from the infrastructure environment and,under the given resource conditions,use core technologies such as the elementization of network baselines,the dynamic aggregation of resources,and collaborative software and hardware arrangements to generate the capability of the“network of networks.”This makes it possible to construct an ideal network system that is designed for change and capable of symbiosis and coexistence with the generative network morpha in the spatiotemporal dimensions.An environment test for principle verification shows that the generated representative application network modalities can not only coexist without mutual influence but also independently match well-defined multimedia services or custom services under the constraints of technical and economic indicators.展开更多
The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility,such as the determination of the chromosomes involved or the correlation with patient features.For this pur...The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility,such as the determination of the chromosomes involved or the correlation with patient features.For this purpose,a total of 31 testicular tissue samples from individuals consulting for fertility problems were analyzed.Metaphase I cells were evaluated using a sequential methodology combining Leishman stained procedures and multiplex fluorescence in situ hybridization protocols.The number of chromosomal units and chiasmata count per bivalent were established and a hierarchical cluster analysis of the individuals was performed.The relationship of the seminogram and the karyotype over recombination were evaluated using Poisson regression models.Results obtained in this study show a significant percentage of infertile individuals with altered meiotic behavior,mostly specified as a reduction in chiasmata count in medium and large chromosomes,the presence of univalents,and the observation of tetraploid metaphases.Moreover,the number and the type of anomalies were found to be different between cells of the same individual,suggesting the coexistence of cell lines with normal meiotic behavior and cell lines with abnormalities.In addition,chromosomal abnormalities in metaphase I are significantly associated with oligozoospermia and/or polymorphic karyotype variants.展开更多
Leaf biochemical properties have been widely assessed using hyperspectral reflectance information by inversion of PROSPECT model or by using hyperspectral indices, but few studies have focused on arid ecosystems. As a...Leaf biochemical properties have been widely assessed using hyperspectral reflectance information by inversion of PROSPECT model or by using hyperspectral indices, but few studies have focused on arid ecosystems. As a dominant species of riparian ecosystems in arid lands, Populus euphratica Oliv. is an unusual tree species with polymorphic leaves along the vertical profile of canopy corresponding to different growth stages. In this study, we evaluated both the inversed PROSPECT model and hyperspectral indices for estimating biochemical properties of P. euphratica leaves. Both the shapes and biochemical properties of P. euphratica leaves were found to change with the heights from ground surface. The results indicated that the model inversion calibrated for each leaf shape performed much better than the model calibrated for all leaf shapes, and also better than hyperspectral indices. Similar results were obtained for estimations of equivalent water thickness (EWT) and leaf mass per area (LMA). Hyperspectral indices identified in this study for estimating these leaf properties had root mean square error (RMSE) and R2 values between those obtained with the two calibration strategies using the inversed PROSPECT model. Hence, the inversed PROSPECT model can be applied to estimate leaf biochemical properties in arid ecosystems, but the calibration to the model requires special attention.展开更多
Stereocomplex(SC)crystallization has been an effective way to improve the physical performances of stereoregular polymers.However,the competition between homo and SC crystallizations can lead to more complicated cryst...Stereocomplex(SC)crystallization has been an effective way to improve the physical performances of stereoregular polymers.However,the competition between homo and SC crystallizations can lead to more complicated crystallization kinetics and polymorphic crystalline structure in stereocomplexable polymers,which influences the physical properties of obtained materials.Herein,we select the medium-molecular-weight(MMW)poly(L-lactic acid)/poly(D-lactic acid)(PLLA/PDLA)asymmetric blends with different PDLA fractions(fD=0.01-0.5)as the model system and investigate the effects of fD and crystallization temperature(Tc)on the crystallization kinetics and polymorphic crystalline structure.We observe the fractionated(i.e.,multistep)crystallization kinetics and the formation of peculiar β-form homocrystals(HCs)in the asymmetric blends under quiescent conditions,which are strongly influenced by both fD and Tc.Precisely,crystallization of β-form HCs is favorable in the MMW PLLA/PDLA blends with high fD(≥0.2)at a low Tc(80-100℃).It is proposed that the formation of metastable β-form HCs is attributed to the conformational matching between β-form HCs and SCs,and the stronger constrain effects of precedingly-formed SCs in the early stage of crystallization.Such effects can also cause the multistep crystallization kinetics of MMW PLLA/PDLA asymmetric blends in the heating process.展开更多
To the Editor:Hepatocellular adenomas(HCAs)consist of benign liver tumors favored by the use of oral contraceptives,which preferentially occur in women.[1,2]They expose to the risk of hemorrhage(20%of cases)and more r...To the Editor:Hepatocellular adenomas(HCAs)consist of benign liver tumors favored by the use of oral contraceptives,which preferentially occur in women.[1,2]They expose to the risk of hemorrhage(20%of cases)and more rarely,to the risk of malignant transformation(4%-10%of cases).[3,4]Multiple HCAs,which are defined by the presence of 10 or more展开更多
Echinotriton chinhaiensis is a critically endangered salamander and its distribution is restricted to Ningbo, Zhejiang Province of China. In this study, we developed and characterized fifteen polymorphic microsatellit...Echinotriton chinhaiensis is a critically endangered salamander and its distribution is restricted to Ningbo, Zhejiang Province of China. In this study, we developed and characterized fifteen polymorphic microsatellite loci for E. ehinhaiensis from dinucleotide- and tetranucleotide- enriched library. The number of alleles ranges from 4 to 12 with an average of 7.27 alleles per locus. The observed and expected heterozygosities values were from 0.250 to 0.844 and 0.511 to 0.872 with an average value of 0.596 and 0.722; respectively. The polymorphic microsatellite loci described in this paper are useful in the further study on genetic diversity and gene flow, which would be helpful to formulate effective conservation strategies for the E. chinhaiensis.展开更多
Ventricular fibrillation (VF) is a malignant arrhythmia, usually initiated by a ventricular premature contraction (VPC) during the vulnerable period of cardiac repolarization. Ablation therapy for VF has been desc...Ventricular fibrillation (VF) is a malignant arrhythmia, usually initiated by a ventricular premature contraction (VPC) during the vulnerable period of cardiac repolarization. Ablation therapy for VF has been described and increasingly reported. Targets for VF triggers are VPCs preceded by Purkinje potentials or from the right ventricular outflow tract (RVOT) in structurally normal hearts, and VPC triggers preceded by Purkinje potentials in ischemic cardiomyopathy. During the session, mapping should be focused on the earliest activation and determining the earliest potential is the key to a successful ablation. However, suppression of VF can be achieved by not only the elimination of triggering VPCs, but also by substrate modification of possible reentry circuits in the Purkinje network, or between the PA and RVOT. The most important issue before the ablation session is the recording of the 12-lead ECG of the triggering event, which can prove invaluable in regionalizing the origin of the triggering VPC for more detailed mapping. In cases where the VPC is not spontaneous or inducible, ablation may be performed by pace mapping. Further studies are needed to evaluate the precise mechanisms of this arrhythmia.展开更多
Two polymorphic forms (forms I and IV) of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. ...Two polymorphic forms (forms I and IV) of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. Form I crystallizes in the triclinic system, space group P1^- with Z= 2, a = 7.6943(8), b = 7.9347(9), c = 13.8558(15) A, a = 85.971(3), β = 85.619(2), γ = 65.974(3)°, V = 769.66(14) A^3, Dc= 1.384 g/cm^3, formula C13H19C1NOBr, F(000) = 328, p = 2.83 mm^-1, the final R = 0.0579 and wR = 0.1282 for 1756 observed reflections with I 〉 2σ(I). Another polymorphic form, IV, belongs to the orthorhombic system, space group Pbca with a = 8.6365(3), b = 12.4167(4), c = 27.7299(9) A, Z = 8, V= 2973.67(17) A^3, Dc= 1.432 g/cm^3, formula C13H19CINOBr, F(000) = 1312,μ = 2.93 mm^-1, the final R = 0.044 and wR = 0.1093 for 2018 observed reflections with I 〉 2σ(I). In the crystal structure of the two polymorphic forms, expected proton transfer from HBr to amino group of bupropion molecule occurs and intramolecular and intermolecular hydrogen bonds N-H…Br are formed. These interactions result in hydrogen-bond dimers in these two forms. The bupropion molecule adopts different conformations in the two investigated solid state modifications.展开更多
基金the National Natural Science Foundation of China(U24A20101).
摘要As a distinctive unshaped refractory material used in steelmaking induction furnace linings,significant variations in raw material performance,particularly erosion resistance,have been observed across silica sources from different regions.To clarify the causes of performance discrepancies and reveal the erosion resistance mechanisms,erosion resistance experiments were conducted on three quartzite raw materials from distinct regions.Furthermore,the enhancement effects of mineralizers on the raw material with the poorest performance were investigated,and the erosion resistance mechanisms of representative raw materials and mineralization effects in silica ramming materials were proposed.The results demonstrated that the presence of dolomite and iron oxide in raw materials is critical for improving the erosion resistance of silica ramming materials.However,the material with 1 wt.%dolomite as a standalone mineralizer exhibited optimal erosion resistance compared to iron oxide composite mineralizers.This improvement is attributed to the formation of uniformly distributed tridymite and an appropriate liquid phase,which mitigates volume expansion effects caused by quartz phase transformation,thereby minimizing aggregate cracking.Additionally,magnesium derived from dolomite plays a specialized role in the operational environment,with the synergistic effects of these two factors collectively enhancing the material’s erosion resistance.
基金funding support by the National Natural Science Foundation of China(52276076 and 52120105009)the Thousand Young Talents Program of China(BE0200006)+2 种基金funding support by the Department for Energy Security and Net Zero,ACT Program(Accelerating CCS Technologies,Horizon2020,691712)for Project NEXTCCUS(327327)the European Union’s Horizon Europe research and innovation program for the SUNPEROM project,Grant Agreement No.101223212University College London’s Research,Innovation and Global Engagement,UCL–Korea University Strategic Partner Fund for their financial support。
摘要Metal halide perovskites(MHPs)have been accelerating next generation high performance solar cells due to their high charge carrier transport and optoelectronic properties.However,their thermoelectric properties fall behind their optoelectronic counterparts,although they have ultralow thermal conductivities and are highly suitable for low grade heat harvesting.A major challenge is how to efficiently dope MHPs in order to achieve high electrical conductivities.As the state-of-the-art MHP for thermoelectric energy conversion,CsSnI3 shows unusual metallic behavior due to the intrinsic Sn vacancies,but it undergoes complex polymorphic phase transitions which hinders its carrier mobility.In this work,we report,for the first time,synthesis of a novel MHP-based thermoelectric device using bulk CsSnI3.This is achieved by leveraging stable polymorphic phase mixing(of orthorhombic and tetragonal phases)and electronic heterostructure.CsSnI3 synthesized by spark-plasma sintering with carbon fiber inclusion shows highly enhanced Seebeck coefficient of~250μV/K,resulting from successful control of the degree of polymorphic phase mixing.The CsSnI3 demonstrates high electrical conductivity of~8400 S/m,attributed to its high carrier mobility.Our approach to control the phase mixing suppresses lattice thermal conductivity to~0.4 W/(m K)through the phonon-boundary scattering.First-principle calculations of the two phases and the phase-interface confirm the strong effect of hybridization and reconstruction of structure at the interface of two phases,which decouples the Seebeck coefficient from electrical conductivity here.The optimized CsSnI3 achieves a power factor of 311μW/(m K2)and ZT of 0.27±0.04,the highest among all reported bulk MHPs.The MHP-based thermoelectric device operates stably across temperature differences of 40 to 260 K,delivering a power density of 3.5 W/m2.This work unlocks the potential of emerging MHPs for thermoelectric devices for low-grade heat harvesting.This could also enable synergistic cooperation between photovoltaic and thermoelectric effects in MHPs for more efficient renewable solar and thermal energy co-harvesting.
基金funded by National Natural Science Foundation of China Youth Science Foundation(Grant No.12402450)。
摘要Hexanitrohexaazaisowurtzitane(CL-20)is a high-energy explosive widely used in composite explosives and propellants,but its application is severely limited by thermally inducedε-to-γpolymorphic transition and high solubility in nitrate ester solvents.The transition reduces energy density and increasing sensitivity,and the solubility causes dissolution-recrystallization defects(e.g.,voids,compositional inhomogeneities)during long-term storage.To address these issues while preserving its high energetic performance,this study developed a polydopamine@polyvinylidene fluoride(PDA@PVDF)dual-coating strategy,fabricating CL-20 composite particles with a core-shell structure.In-situ X-ray diffraction(XRD)results confirmed that theε-to-γphase transition temperature of CL-20 increased from 110℃(pristine CL-20)to 140℃.Meanwhile,the CL-20@PDA@9%PVDF sample exhibited the lowest solubility and the best solvent resistance,and the solubility of CL-20 in nitrate ester solvents was drastically reduced from 0.229 g/100 g–0.026 g/100 g,an 88.6%decrease,effectively enhancing its structural and solvent resistance stability.For energetic performance,when mixed with aluminum powder at a 7:3 mass ratio,the CL-20@PDA@9%PVDF/Al composite achieved a combustion heat of 8275 J/g,8.7%higher than that of the unmodified Al/CL-20 system(7611 J/g).Combustion pressure tests showed that although the modified system exhibited slightly lower initial peak pressure and pressure rise rate due to dilute CL-20 content from inert coatings,it presented a unique"delayed enhancement"effect,with pressure gradually surpassing and ultimately exceeding that of the unmodified system in the middle and late combustion stages,enabling more sustained high-pressure output.This work realizes the synergistic optimization of CL-20's polymorphic/solvent stability and energetic performance,providing a feasible and scalable approach for the practical application of CL-20 in advanced energetic systems.
摘要Modern malware is increasingly employing polymorphism,packing,and metamorphism to evade traditional signature-based detection.Because of this,there is an urgency to have more reliable classification systems.Visual malware analysis,where binaries are converted into grayscale images,has demonstrated potential in revealing structural patterns of malware family classification.However,recent methods mostly rely on single-stream,lightweight Convolutional Neural Networks(CNNs).These models have a major blind spot.The visual representation textures can be heavily obscured without changing the underlying malicious code,causing severe performance drops on newer or even rare malware classes.This paper presents a Hybrid Multi-Modal Deep Learning framework to fix this vulnerability.The proposed dual-stream architecture uses image recognition via EfficientNetB0 alongside metadata analysis using 1D-convolutional byte embeddings.This paper evaluated the framework on the modern MalwareVision-2025 dataset(approximately 125000 samples)and the legacy Malimg dataset(9339 samples).On MalwareVision-2025,the model reached a weighted accuracy of 88.44%and achieved 100%benign recall on the evaluated split.The testing across both datasets shows that combining visual and structural features reduces modality collapse.This creates a much stronger system compared to using either input type on its own.In particular,the hybrid approach improves detection performance on deeply hidden contemporary threats,including the AveMariaRAT and CobaltStrike families.
基金funded by the Technology Development Board(TDB)of India's Ministry of Science and Technology(TDB/M-25/2018-19).
摘要Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Phytohemagglutinin-M,Gibco)stimulated blood T lymphocytes by Giemsa trypsin Giemsa banding and Ag-NOR banding on 580 couples with a history of idiopathic recurrent pregnancy loss and 240 couples from the general population.Thirty good chromosomal spreads were captured,karyotyped,and analyzed.The karyotypes were designated using the International System for Human Cytogenomic Nomenclature 2024.Pearson Chi-square test was used to compare the frequency of chromosomal polymorphism variations in the idiopathic recurrent pregnancy loss group with the general population group.Results:A conventional cytogenetic investigation revealed that 45.43%of couples experiencing idiopathic recurrent pregnancy loss presented with various types of chromosomal polymorphic variants,compared to 11.88%in the general population.The overall frequency of these chromosomal polymorphic variants was significantly higher in the idiopathic recurrent pregnancy loss group compared to the general population group(OR 9.97,95%CI 6.99-14.21;P<0.05).Additionally,the prevalence of polymorphic variants was higher among males(49.14%)than females(41.72%)(P=0.01).Conclusions:Chromosomal polymorphic analysis may play a crucial role in the assessment and careful clinical management of cases with idiopathic recurrent pregnancy loss,especially when no other conclusive reasons are identified during the initial evaluation.Therefore,heteromorphism should not be overlooked while investigating the causes of idiopathic recurrent pregnancy loss.
摘要Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to implementation of precision medicine.This inherited arrhythmia syndrome induces potentially lethal ventricular arrhythmias by catecholaminergic stress in normally structured hearts and is most commonly due to ryanodine receptor 2(RyR2)mutations in 60%-70%families.Pathophysiology involves gain-of-function mutations forming“leaky”calcium channels with increased sensitivity to catecholaminergic stimulation.Store overload-induced calcium release is a key mechanism whereby mutations reduce thresholds for spontaneous calcium release events.Complex mitochondrial-sarcoplasmic reticulum crosstalk amplifies dysfunction by calciuminduced mitochondrial overload and generation of reactive oxygen species.Modern diagnosis combines next-generation sequencing with functional confirmation using patient-specific induced pluripotent stem cells,allowing for personalized stratification of risk.Male gender,early age of onset,frequent attacks,and central domain mutations are high-risk factors.Exercise testing continues to play a central role in diagnosis and follow-up.Treatment has progressed from empiric β-blocker therapy to mutation-targeted therapy for the condition.β-blockers decrease arrhythmia by 60%-70%,and flecainide adjunct therapy improves success to 80%-90%via direct RyR2 modulation.Carvedilol is more beneficial because of the added alpha-blocking and antioxidant effect.Patients who are refractory are aided by left cardiac sympathetic denervation or implantable cardioverter defibrillators.Upcoming precision medicine includes clustered regularly interspaced short palindromic repeat-associated protein Cas9 gene editing,targeted molecular therapy,and artificial intelligence-based management.RyR2 stabilizers,calmodulin modulators,and mitochondrial protective therapies are promising targeted therapies.Implementation occurs through multidisciplinary care involving genetics,cardiology,and counseling services.Critical challenges are the management of asymptomatic carriers,the definition of exercise limitation,and the validation of biomarkers.Catecholaminergic polymorphic ventricular tachycardia illustrates successful translation of molecular cardiology with a paradigm for inherited arrhythmia syndromes and prevention of sudden cardiac death with mechanistically informed,personalized therapeutic strategies.
基金supported by the National Natural Science Foundation of China(Grant Nos.92365203,12534013,12174096,and 12474167)the Hunan Provincial Science Fund for Distinguished Young Scholars(Grant No.2022JJ10060)+1 种基金the Science and Technology Innovation Program of Hunan Province(Grant Nos.2025ZYJ001 and 2021RC4026)the Science Fund for Self-initiated Innovation of NUDT。
摘要The two-dimensional van der Waals layered semiconductor In2Se3 has emerged as a promising candidate for non-volatile ferroelectric memory,optoelectronic devices,and polymorphic phase engineering.Polymorphic In2Se3 typically stabilizes in three distinct phases:α-,β′-,and β*-In2Se3,each dominant within specific temperature ranges.Although the crystal structures and ferroelectric properties of these phases have been widely studied,the unambiguous assignment of their in-plane and out-of-plane ferroelectric behaviors,as well as the mechanisms governing their phase transitions,remains a subject of active debate.In this study,we investigate the evolution of atomic and electronic structures in molecular beam epitaxy-grown ultrathin In2Se3 films through correlated microstructural and macroscopic physical property analysis.By employing scanning tunneling microscopy/spectroscopy,temperature-dependent Raman spectroscopy,and piezoresponse force microscopy,we demonstrate a reversible temperature-induced phase transition between the in-plane ferroelectric β*and antiferroelectric β′phases.Furthermore,we confirm robust out-of-plane ferroelectric polarization in the as-grown films and achieve an electric-field-driven transition from the β*to β′phase.Our findings not only advance the fundamental understanding of phase transitions and polarization evolution in two-dimensional semiconductors but also open new avenues for the design of tunable,non-volatile ferroelectric memory devices.
基金financially supported by the Major Research Plan of National Natural Science Foundation of China(Key Programme)(No.92359204)the Postdoctoral Fellowship Program of CPSF(No.GZB20230990)+2 种基金the First Affiliated Hospital of Naval Medical University(Nos.2023PY26,2025SZ10,and 2023QD10)Naval Medical University(No.2024QN029)the State Key Laboratory of Molecular Engineering of Polymers at Fudan University(No.K2023-24)
摘要Generating excessively reactive oxygen species(ROS)within tumor cells is a widely adopted therapeutic strategy.However,single-type ROS exhibit fixed attack sites and mechanisms of action in tumor cells,rendering them susceptible to resistance via cellular repair mechanisms.To overcome this limitation,this study proposes a polymorphic ROS strategy that simultaneously induces multiple types of ROS to enhance the therapeutic efficacy.A nanoplatform named as AuPd@MnxOy/L/DOX(APM@L/D)is developed.AuPd core can catalyze oxygen to generate superoxide anions(O2·-),and the released multivalent manganese ions in tumor can trigger the production of singlet oxygen(1O2)and hydroxyl radicals(·OH).The polymorphic ROS(O2·-,1O2,·OH)with different reactivity,lifetime,and diffusion capacity can achieve multifaceted oxidative damage,significantly improving tumor eradication.Concurrently,photothermal heating and DOX release can enhance catalytic reaction rate and intracellular hydrogen peroxide levels,further amplifying polymorphic ROS generation.Both in vitro and in vivo experiments demonstrate that AP-M@L/D induces significant intracellular oxidative stress and enhances cell-killing efficiency by activating the apoptotic pathway.In summary,the spatiotemporally controllable polymorphic ROS can enhance antitumor efficacy and provide a guidance for ROS therapy.
基金supported by funding from the National Natural Science Foundation of China(U1603231,32030071)a Grant of Innovation Environment Construction of the Xinjiang Uygur Autonomous Region,China(PT2315).
摘要An underlying assumption for the size-dependent sex allocation(SDs)hypothesis is that the plasticity of bisexual investments in hermaphrodites would be larger in female than in male allocation,but it has rarely been critically evaluated.Among five sexual morphs in a sexually polymorphic desert herb Geranium transversale,gynomonoecious individuals were the largest,and males were the smallest,while hermaphroditic and andromonoecious plants and females did not differ significantly in plant size.The total number of flowers increased with plant size in all five sexual morphs;in gynomonoecious and andromonoecious plants this was due to an increase in the number of perfect flowers rather than pistillate or staminate flowers.Flower size increased with plant size in hermaphroditic and gynomonoecious plants(due to an increase in the size of perfect but not of unisexual flowers).The sizes of staminate flowers in andromonoecious and male plants,and pistillate flowers in gynomonoecious plants did not increase with plant size,and pistil mass increased but stamen mass decreased with plant size.The coefficient of variation(CV)in pistil and stamen mass among 21o plants in four of the sexual morphs(excluding female plants)indicated that variation in resource allocation among individuals was higher in female than male functions.Both flower number and flower size generally increased with plant size in G.transversale,supporting the SDS hypothesis.The relatively higher plasticity(CV)in female than male allocation has not been reported before,providing a cue for understanding why the female-biased allocation associated with plant size is popular in flowering plants.
摘要BACKGROUND Gamma-aminobutyric acid type A receptor has long been acknowledged as a key target in the pathophysiology of epilepsy.The GABRA1 and GABRG2 genes encode theα1 andγ2 subunits of the gamma-aminobutyric acid type A receptor,a key protein implicated in the development of epilepsy.However,the specific association of the GABRA1 IVS11+15 A>G rs2279020 and GABRG2 G3145A rs211013 polymorphisms with antiepileptic drug resistance has been elucidated in only a limited number of investigations.AIM To elucidate the association between GABRA1 IVS11+15 A>G rs2279020 and GABRG2 G3145A rs211013 gene mutations and drug resistance in epilepsy patients.METHODS A total of 100 epilepsy patients(50 drug responsive and 50 drug resistant subjects)were recruited and rs2279020-and rs211013-polymorphism analyzed by restriction fragment length polymorphism-polymerase chain reaction technique.RESULTS For GABRA1 rs2279020 polymorphism,AG genotype exhibited risk association with an odds ratio of 0.966(95%confidence interval=0.346-2.698)with P value=0.948;however,this association did not achieve statistical significance(P=0.948).Additionally,a higher risk association was identified with the GG genotype,with an odds ratio of 1.808(P=0.382).GABRG2 rs211013 polymorphism revealed no significant association with drug resistance.CONCLUSION The GABRA1 rs2279020 genetic variation is associated with an increased risk for the AG and GG variants,although this association was not statistically significant.Limited investigations have explored the relevance of genetic variations in epilepsy and drug resistance.Longitudinal research is needed to better understand their significance in epilepsy management and to optimize therapeutic strategies.
基金financially supported by the Major Science and Technology Innovation Project of Shandong Province(No.2019JZZY010352)Natural Science Foundation of Shandong Province(ZR2019MB072)Taishan Scholar Program
摘要For the solid-solid transformation from formⅡto formⅠof isotactic polybutene-1(iPB),the temperature dependence of formⅠnucleation and growth was deemed to control the transformation process.However,the relationship between formⅠformation and formⅡdisappearance in the transformation process is not clear.In this work,the spontaneous crystal transformation from formⅡtoⅠof iPB with 81 mol%mmmm sequence concentration is studied firstly by tracking the two processes,the decay of formⅡand the yielding of formⅠin a wide range of temperature spanning from 0℃to 50℃and in a long transformation time ranging from 5 min to 65 days with in situ FTIR and WAXD.Unlike the literature reports,the decay rate of formⅡis firstly found to be lower than the yielding rate of formⅠat all studied temperatures,especially at low transition temperature.This is attributed to the amorphous chains which locate near crystal lamella participating into the nucleation of formⅡ.The regular chain folding and growth of i PB formⅠfrom amorphous chains containing short isotactic sequences also lead to an increase in crystallinity of formⅠcompared with that of initial formⅡcrystallized at 60℃.An increase in the annealing temperature results in decrease in crystallinity and increase in lamellae thickness of i PB formⅠ.
基金supported by the National High Technology Research and Development Program of China(Grant No.2006AA100101)National Science and Technology Support Program of China(Grant No.2006BAD01A01-5)+1 种基金Special Program for Rice Scientific Research,Ministry of Agriculture,China(Grant No.nyhyzx 07-001-006)Super Rice Breeding and Demonstration Program,Ministry of Agriculture,China and Jiangsu Agricultural Scientific Self-innovation Fund,China(Grant No.CX[07]603)
摘要The translucent endosperm trait in a japonica rice variety'Kantou 194'is controlled by a Wx-mq gene which is allelic to Wx locus by genetic analysis and allelic test.The amylose content analysis showed that an intermediate amylose content between those of glutinous and non-glutinous rice existed in endosperm of homozygous Wx-mq genotype.The slight changes of amylose content in different varieties and F1 grains with an identical Wx-mq genotype might be influenced by dissimilar genetic background.To identify the Wx-mq genotype simply and rapidly,a cleaved amplified polymorphic sequence(CAPS)marker was designed.The result from the molecular detection indicated that it could be used for marker-assisted selection for low amylose content varieties in rice breeding.
基金supported by the National Key Research and Development Program of China(2022YFB2901403)the Songshan Laboratory Project(221100210900-02).
摘要The question of whether an ideal network exists with global scalability in its full life cycle has always been a first-principles problem in the research of network systems and architectures.Thus far,it has not been possible to scientifically practice the design criteria of an ideal network in a unimorphic network system,making it difficult to adapt to known services with clear application scenarios while supporting the ever-growing future services with unexpected characteristics.Here,we theoretically prove that no unimorphic network system can simultaneously meet the scalability requirement in a full cycle in three dimensions—the service-level agreement(S),multiplexity(M),and variousness(V)—which we name as the“impossible SMV triangle”dilemma.It is only by transforming the current network development paradigm that the contradiction between global scalability and a unified network infrastructure can be resolved from the perspectives of thinking,methodology,and practice norms.In this paper,we propose a theoretical framework called the polymorphic network environment(PNE),the first principle of which is to separate or decouple application network systems from the infrastructure environment and,under the given resource conditions,use core technologies such as the elementization of network baselines,the dynamic aggregation of resources,and collaborative software and hardware arrangements to generate the capability of the“network of networks.”This makes it possible to construct an ideal network system that is designed for change and capable of symbiosis and coexistence with the generative network morpha in the spatiotemporal dimensions.An environment test for principle verification shows that the generated representative application network modalities can not only coexist without mutual influence but also independently match well-defined multimedia services or custom services under the constraints of technical and economic indicators.
基金supported by the Project 2009SGR-00282(Generalitat deCatalunya,Spain)Project SAF2010-22241(Ministerio de Ciencia y Tecnología,Spain)Project CF-180034(Universitat Autònoma de Barcelona,Spain).
摘要The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility,such as the determination of the chromosomes involved or the correlation with patient features.For this purpose,a total of 31 testicular tissue samples from individuals consulting for fertility problems were analyzed.Metaphase I cells were evaluated using a sequential methodology combining Leishman stained procedures and multiplex fluorescence in situ hybridization protocols.The number of chromosomal units and chiasmata count per bivalent were established and a hierarchical cluster analysis of the individuals was performed.The relationship of the seminogram and the karyotype over recombination were evaluated using Poisson regression models.Results obtained in this study show a significant percentage of infertile individuals with altered meiotic behavior,mostly specified as a reduction in chiasmata count in medium and large chromosomes,the presence of univalents,and the observation of tetraploid metaphases.Moreover,the number and the type of anomalies were found to be different between cells of the same individual,suggesting the coexistence of cell lines with normal meiotic behavior and cell lines with abnormalities.In addition,chromosomal abnormalities in metaphase I are significantly associated with oligozoospermia and/or polymorphic karyotype variants.
基金supported by the West Light Talents Cultivation Program of Chinese Academy of Sciences (XBBS 200801)the National Natural Science Foundation of China (40801146)the JSPS Project (21403001)
摘要Leaf biochemical properties have been widely assessed using hyperspectral reflectance information by inversion of PROSPECT model or by using hyperspectral indices, but few studies have focused on arid ecosystems. As a dominant species of riparian ecosystems in arid lands, Populus euphratica Oliv. is an unusual tree species with polymorphic leaves along the vertical profile of canopy corresponding to different growth stages. In this study, we evaluated both the inversed PROSPECT model and hyperspectral indices for estimating biochemical properties of P. euphratica leaves. Both the shapes and biochemical properties of P. euphratica leaves were found to change with the heights from ground surface. The results indicated that the model inversion calibrated for each leaf shape performed much better than the model calibrated for all leaf shapes, and also better than hyperspectral indices. Similar results were obtained for estimations of equivalent water thickness (EWT) and leaf mass per area (LMA). Hyperspectral indices identified in this study for estimating these leaf properties had root mean square error (RMSE) and R2 values between those obtained with the two calibration strategies using the inversed PROSPECT model. Hence, the inversed PROSPECT model can be applied to estimate leaf biochemical properties in arid ecosystems, but the calibration to the model requires special attention.
基金financially supported by the National Natural Science Foundation of China(No.21873083).
摘要Stereocomplex(SC)crystallization has been an effective way to improve the physical performances of stereoregular polymers.However,the competition between homo and SC crystallizations can lead to more complicated crystallization kinetics and polymorphic crystalline structure in stereocomplexable polymers,which influences the physical properties of obtained materials.Herein,we select the medium-molecular-weight(MMW)poly(L-lactic acid)/poly(D-lactic acid)(PLLA/PDLA)asymmetric blends with different PDLA fractions(fD=0.01-0.5)as the model system and investigate the effects of fD and crystallization temperature(Tc)on the crystallization kinetics and polymorphic crystalline structure.We observe the fractionated(i.e.,multistep)crystallization kinetics and the formation of peculiar β-form homocrystals(HCs)in the asymmetric blends under quiescent conditions,which are strongly influenced by both fD and Tc.Precisely,crystallization of β-form HCs is favorable in the MMW PLLA/PDLA blends with high fD(≥0.2)at a low Tc(80-100℃).It is proposed that the formation of metastable β-form HCs is attributed to the conformational matching between β-form HCs and SCs,and the stronger constrain effects of precedingly-formed SCs in the early stage of crystallization.Such effects can also cause the multistep crystallization kinetics of MMW PLLA/PDLA asymmetric blends in the heating process.
摘要To the Editor:Hepatocellular adenomas(HCAs)consist of benign liver tumors favored by the use of oral contraceptives,which preferentially occur in women.[1,2]They expose to the risk of hemorrhage(20%of cases)and more rarely,to the risk of malignant transformation(4%-10%of cases).[3,4]Multiple HCAs,which are defined by the presence of 10 or more
基金financially supported by the National Natural Science Foundation of China (30770316)
摘要Echinotriton chinhaiensis is a critically endangered salamander and its distribution is restricted to Ningbo, Zhejiang Province of China. In this study, we developed and characterized fifteen polymorphic microsatellite loci for E. ehinhaiensis from dinucleotide- and tetranucleotide- enriched library. The number of alleles ranges from 4 to 12 with an average of 7.27 alleles per locus. The observed and expected heterozygosities values were from 0.250 to 0.844 and 0.511 to 0.872 with an average value of 0.596 and 0.722; respectively. The polymorphic microsatellite loci described in this paper are useful in the further study on genetic diversity and gene flow, which would be helpful to formulate effective conservation strategies for the E. chinhaiensis.
摘要Ventricular fibrillation (VF) is a malignant arrhythmia, usually initiated by a ventricular premature contraction (VPC) during the vulnerable period of cardiac repolarization. Ablation therapy for VF has been described and increasingly reported. Targets for VF triggers are VPCs preceded by Purkinje potentials or from the right ventricular outflow tract (RVOT) in structurally normal hearts, and VPC triggers preceded by Purkinje potentials in ischemic cardiomyopathy. During the session, mapping should be focused on the earliest activation and determining the earliest potential is the key to a successful ablation. However, suppression of VF can be achieved by not only the elimination of triggering VPCs, but also by substrate modification of possible reentry circuits in the Purkinje network, or between the PA and RVOT. The most important issue before the ablation session is the recording of the 12-lead ECG of the triggering event, which can prove invaluable in regionalizing the origin of the triggering VPC for more detailed mapping. In cases where the VPC is not spontaneous or inducible, ablation may be performed by pace mapping. Further studies are needed to evaluate the precise mechanisms of this arrhythmia.
基金supported by the Natural Science Foundation of Zhejiang Province (J200801)
摘要Two polymorphic forms (forms I and IV) of antidepressant bupropion hydrobro- mides were prepared and characterized by powder X-ray single-crystal diffractometer. Lots of commercial substances may consist of form I. Form I crystallizes in the triclinic system, space group P1^- with Z= 2, a = 7.6943(8), b = 7.9347(9), c = 13.8558(15) A, a = 85.971(3), β = 85.619(2), γ = 65.974(3)°, V = 769.66(14) A^3, Dc= 1.384 g/cm^3, formula C13H19C1NOBr, F(000) = 328, p = 2.83 mm^-1, the final R = 0.0579 and wR = 0.1282 for 1756 observed reflections with I 〉 2σ(I). Another polymorphic form, IV, belongs to the orthorhombic system, space group Pbca with a = 8.6365(3), b = 12.4167(4), c = 27.7299(9) A, Z = 8, V= 2973.67(17) A^3, Dc= 1.432 g/cm^3, formula C13H19CINOBr, F(000) = 1312,μ = 2.93 mm^-1, the final R = 0.044 and wR = 0.1093 for 2018 observed reflections with I 〉 2σ(I). In the crystal structure of the two polymorphic forms, expected proton transfer from HBr to amino group of bupropion molecule occurs and intramolecular and intermolecular hydrogen bonds N-H…Br are formed. These interactions result in hydrogen-bond dimers in these two forms. The bupropion molecule adopts different conformations in the two investigated solid state modifications.