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Ensitrelvir postexposure prophylaxis for COVID-19:Translating trial efficacy into clinical practice 认领 引用
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作者 Md Mohsin Sarker 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第6期237-238,共2页
Despite vaccination and widespread acquired immunity,COVID-19 continues to impose a substantial global burden,driven by waning immunity and the emergence of new variants.Households are key sites for transmission of se... Despite vaccination and widespread acquired immunity,COVID-19 continues to impose a substantial global burden,driven by waning immunity and the emergence of new variants.Households are key sites for transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,with secondary attack rates of up to 32%to 48%among household contacts during the omicron era[1].Despite this well-documented transmission burden,no oral antiviral had previously demonstrated significant efficacy as postexposure prophylaxis in exposed household contacts,leaving a critical gap in clinical management[2,3]. 展开更多
关键词 postexposure prophylaxis severe acute respiratory syndrome coronavirus ensitrelvir widespread acquired immunity covid waning immunity oral antiviral global burden
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A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice 认领 引用 被引量：13
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作者 Peihua Niu Guangyu Zhao +4 位作者 Yao Deng Shihui Sun Wenling Wang Yusen Zhou Wenjie Tan 《Science China(Life Sciences)》 SCIE CAS CSCD 2018年第10期1280-1282,共3页
Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http:/... Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http://gffzz36b398b81f8a4a4chob5n696ukv6b6upk.ffgz.tsg.suse.edu.cn/emergencies/mers-cov/en/). MERS-CoV causes an acute and severe respiratory illness with a high mortality rate(~35%) in humans (Shi et al., 2017, Zaki et al., 2012).Neutralizing antibodies targeting the spike of MERS-CoV have been shown to be a therapeutic option for treatment of lethal disease (Agrawal et al., 2016, Ying et al., 2014). 展开更多
关键词 provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice A novel human mAb MERS-GD27 Figure DPP
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Animal bites and tetanus prophylaxis 认领 引用
3
作者 Hasan Tahsin Gozdas 《Journal of Acute Disease》 2017年第2期92-92,共1页
Dear Editor,In a recent article,Babazadehet al.investigated the cost of postexposure rabies prophylaxis which is a signifant issue on the epidemiology of acute animal bites(1)However,I have some comments regarding to ... Dear Editor,In a recent article,Babazadehet al.investigated the cost of postexposure rabies prophylaxis which is a signifant issue on the epidemiology of acute animal bites(1)However,I have some comments regarding to this article.Animal bites are often dirty wounds.So,every patient suffered from an animal bite should be evaluated for the necessity of tetanus prophylaxis,which is also an important subpart of postexposure rabies prophylaxis[2].So,the cost of tetanus prophylaxis also increases the economic burden.Information on how many patients received tetanus prophylaxis and the financial burden of this will bring a more comprehensive view. 展开更多
关键词 Babazadeh Postexposure rabies Comprehensive view.
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Bites from the same dog,different outcomes for two patients:a case report 认领 引用 被引量：6
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作者 Xue-Yong Huang Xing-Le Li +4 位作者 Shu-Yu Wu Yu-Lei Gu Xin-Jun Lv John David Klena Bian-Li Xu 《Infectious Diseases of Poverty》 SCIE CAS 2017年第1期963-966,共4页
Background:Rabies is a serious reemerging zoonosis in China.At present human rabies cases are primarily diagnosed based on clinical presentation.Case presentation:In August 2012,a woman and her son were attacked by a ... Background:Rabies is a serious reemerging zoonosis in China.At present human rabies cases are primarily diagnosed based on clinical presentation.Case presentation:In August 2012,a woman and her son were attacked by a stray dog in Henan,China.The son received rabies postexposure prophylaxis(wound treatment followed by vaccine,no immunoglobulin),however,the mother did not.Rabies infection was subsequently laboratory confirmed in the mother and she died in December;her son is alive and healthy after 2 years of follow-up.Conclusion:This report documents that the timely utilization of postexposure prophylaxis is a required measure in preventing rabies after exposure to an animal bite. 展开更多
关键词 China Encephalitis Neglected diseases Rabies Rabies atypical manifestations Rabies laboratory diagnosis Rabies postexposure prophylaxis Zoonosis
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