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A Study on the Beliefs and Attitudes of Nurses in Yunnan Province Towards Nurse Prescriptive Authority 认领 引用
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作者 Yulin Lu Jian Chen +3 位作者 Ying Li Jun Yu Yanyu Chen Jiangyu Xue 《Journal of Clinical and Nursing Research》 2025年第1期194-202,共9页
Objective: To investigate the current beliefs and attitudes of nurses in Yunnan Province toward prescriptive authority, analyze the influencing factors, and provide evidence for future research and policy formulation ... Objective: To investigate the current beliefs and attitudes of nurses in Yunnan Province toward prescriptive authority, analyze the influencing factors, and provide evidence for future research and policy formulation to support the establishment of nurses’ prescriptive authority in China. Method: A cross-sectional survey was conducted among 937 nurses in Yunnan Province using the Beliefs and Attitudes Scale on Nurses’ Prescriptive Authority. The scale assessed four dimensions: perceived need, self-efficacy, perceived benefits, and perceived barriers. Multiple linear regression analysis was used to identify factors influencing the overall score and each dimension. Results: The total score of the Beliefs and Attitudes Scale was 89.17 ± 17.69, indicating a moderate level of awareness and positive attitude among nurses. The highest-scoring dimension was perceived benefits (34.94 ± 8.04), while the lowest was perceived barriers (15.23 ± 3.5). Age was identified as a significant factor influencing the overall score and self-efficacy dimension (P < 0.05). Years of practice influenced the perceived benefits dimension (P = 0.051), while gender, age, and professional title were key factors affecting the perceived barriers dimension (P < 0.05). Male nurses and senior nurses demonstrated more caution toward potential risks associated with prescriptive authority. Conclusion: Nurses in Yunnan Province exhibit moderate levels of belief in and attitudes toward prescriptive authority, with age being the most significant influencing factor. Tailored training programs, policy promotion, and practical guidance are recommended to enhance nurses’ understanding and support for prescriptive authority, thereby improving nursing practices and addressing regional healthcare challenges. 展开更多
关键词 Nurses’prescriptive authority Beliefs and attitudes Influencing factors Yunnan Province Nursing policy
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The eligibility criteria,training content,and scope of practice for prescriptive authority for midwives:a modified Delphi study 认领 引用 被引量：3
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作者 Shi-Fan Han Hong-Xia Ren +2 位作者 Xiu-Juan Wang Xiao-Ding Yue Si-Yu Dou 《Frontiers of Nursing》 2019年第3期191-201,共11页
Objective:To investigate the necessary eligibility criteria for prescriptive authority for midwives,gather suggestions from experts on training content for prescriptive authority for midwives,and explore the scope of ... Objective:To investigate the necessary eligibility criteria for prescriptive authority for midwives,gather suggestions from experts on training content for prescriptive authority for midwives,and explore the scope of practice of their prescriptive authority in certain circumstances.The results of this study could serve as a reference for the development of policies on prescriptive authority for midwives.Methods:Based on a literature search and semistructured interviews,a modified Delphi method was first used to conduct 2 rounds of expert consultation on eligibility criteria and training content for prescriptive authority for midwives.This stage included nursing experts(20)and medical experts(16)engaged in midwifery in many tertiary Grade A hospitals in China.Subsequently,consultation on the scope of practice of prescriptive authority for midwives was conducted with nursing experts(18)and medical experts(14)engaged in midwifery in many tertiary Grade A hospitals in China.The suggestions from the experts were analyzed using statistical methods to confirm the eligibility criteria for prescriptive authority,training content,circumstances,scope of practice for prescriptive authority,and the prescription forms.Results:Among the consulted experts,70.59%(the highest acceptance rate)considered an undergraduate degree to be the minimum educational requirement for midwives to be eligible for prescriptive authority,85.29%(the highest acceptance rate)considered the supervisor nurse to be the minimum technical position experience necessary for midwives to be eligible for having prescriptive authority,and 50%(the highest acceptance rate)considered 5 years to be the minimum number of years of experience in the specialty for midwives to be eligible for prescriptive authority.The applicants should at least be practicing at Grade C hospitals,which was the consensus among 91.18%of the consulted experts.Among the consulted experts,100%,100%,97.06%,94.12%,and 94.12%agreed that the applicants should have knowledge in pharmacology,laws and ethics,nursing,diagnostics,and midwifery,respectively.The consulted experts confirmed 22 related course topics and identified 6 specific circumstances in which the midwives could partially practice prescriptive authority,including uterine atony,excessive uterine contraction,postpartum hemorrhage,premature rupture of fetal membranes,normal labor,and neonatal asphyxia.Under these 6 circumstances,the consulted experts commonly agreed that there were 20 medication prescriptions and 13 auxiliary examination prescriptions that could be prescribed by midwives.Of these prescriptions,51.5%were independent prescriptions,30.3%were protocol prescriptions,and the remaining 18.2%were both independent and protocol prescriptions.Conclusions:Midwives who have an undergraduate degree,supervisor nurse position,and 5 years of practice in Grade C hospitals are considered eligible to apply for prescriptive authority.Partial prescriptive authority could be granted after regulated training in fundamental theories and practices,which could improve the independence and professionalism of midwifery. 展开更多
关键词 Delphi study midwife eligibility criteria training content circumstances scope of practice prescriptive authority prescription forms
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English Grammar Comparison:Descriptive Grammar vs.Prescriptive Grammar 认领 引用
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作者 张婧雯 李易安 《海外英语》 2015年第2期148-149,共2页
English grammar is thought as one of the most important parts in both language learning and teaching. While few people know there is more than one kind of English grammar. This essay provides the features and comparis... English grammar is thought as one of the most important parts in both language learning and teaching. While few people know there is more than one kind of English grammar. This essay provides the features and comparison between two commonly used English grammar, namely descriptive grammar and prescriptive grammar, and assist English teachers to explore further in grammar teaching. 展开更多
关键词 English grammar Descriptive Prescriptive
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A Scalar Compromise Equilibrium for N-Person Prescriptive Games 认领 引用
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作者 H. W. Corley Surachai Charoensri Narakorn Engsuwan 《Natural Science》 2014年第13期1103-1107,共5页
A scalar equilibrium (SE) is defined for n-person prescriptive games in normal form. When a decision criterion (notion of rationality) is either agreed upon by the players or prescribed by an external arbiter, the res... A scalar equilibrium (SE) is defined for n-person prescriptive games in normal form. When a decision criterion (notion of rationality) is either agreed upon by the players or prescribed by an external arbiter, the resulting decision process is modeled by a suitable scalar transformation (utility function). Each n-tuple of von Neumann-Morgenstern utilities is transformed into a nonnegative scalar value between 0 and 1. Any n-tuple yielding a largest scalar value determines an SE, which is always a pure strategy profile. SEs can be computed much faster than Nash equilibria, for example;and the decision criterion need not be based on the players’ selfishness. To illustrate the SE, we define a compromise equilibrium, establish its Pareto optimality, and present examples comparing it to other solution concepts. 展开更多
关键词 Game Theory Equilibria Scalar Equilibrium Compromise Equilibrium Scalar Transformation Prescriptive Analysis
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On Prescriptive and Descriptive Translation Theory 认领 引用
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作者 Zhe Wang 《US-China Foreign Language》 2005年第5期52-54,共3页
This paper analyzes the major characteristics of the prescriptive and descriptive translation theory. Following a brief description of its major features, the paper dwells on the school＇s relevance to the Chinese tra... This paper analyzes the major characteristics of the prescriptive and descriptive translation theory. Following a brief description of its major features, the paper dwells on the school＇s relevance to the Chinese translators. The point is made that the descriptive theory can explain the orientation of all kinds of translations, expand the scope of the field of study and enrich the practice of translation. 展开更多
关键词 prescriptive descriptive translation
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Weimishu prescription(胃糜舒方)alleviates liver-stomach disharmony and chronic gastritis by reducing inflammation and regulating gastric stem cell differentiation 认领 引用
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作者 ZOU Xiaoyun WEI Minmin +5 位作者 JIA Shouning QI Yongfu LI Hailing LIU Yan SHI Xiujuan LI Junru 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期95-109,共15页
OBJECTIVE:To investigate the therapeutic effect of Weimishu prescription(胃糜舒方,WMSP)on chronic gastritis with liver-stomach disharmony(CG-LSD)and elucidate its molecular mechanisms involved in regulating the nuclea... OBJECTIVE:To investigate the therapeutic effect of Weimishu prescription(胃糜舒方,WMSP)on chronic gastritis with liver-stomach disharmony(CG-LSD)and elucidate its molecular mechanisms involved in regulating the nuclear factor kappa-B(NF-κB)inflammatory response and gastric stem cell(GSC)differentiation.METHODS:A CG-LSD rat model was established through a combined protocol involving 56%ethanol and tail-clip stimulation.Rats were administered with low-,medium-,or high-dose WMSP,the positive control drug omeprazole,or high-dose WMSP with the NF-κB agonist phorbol 12-myristate 13-acetate(PMA).Histopathological changes were assessed via hematoxylin and eosin and Td T-mediated d UTP nick end labeling staining.Flow cytometry,immunofluorescence,real-time quantitative polymerase chain reaction,Western blotting,and enzyme-linked immunosorbent assay were performed to evaluate the underlying mechanisms.RESULTS:WMSP significantly increased rat locomotor activity,improved Traditional Chinese Medicine syndrome scores,and ameliorated pathological damage to the gastric mucosa while reducing gastric mucosal epithelial cells apoptosis.WMSP also increased the proportion of Lgr5+Ki67+cells;upregulated muscle,intestine,and stomach specific transcript 1,sex determining region Y-box 2,sex determining region Y-box 9,and homing cell adhesion molecule;and enhanced the levels of pepsinogen C,somatostatin,mucin-6,H+-K+ATPase,and E-cadherin proteins,thereby promoting gastric stem cell survival and differentiation.Furthermore,WMSP alleviated systemic and gastric mucosal inflammation in CG-LSD rats.Mechanistically,WMSP suppressed NF-κB expression,thereby reducing Smadspecific E3 ubiquitin ligase 2 levels,which enhancedβ-catenin and subsequently increased myelocytomatosis oncogene,and axis inhibition protein 2 expression.PMA administration reversed the protective effect of WMSP on CG-LSD rats.CONCLUSIONS:WMSP ameliorated gastric mucosal injury in CG-LSD rats by regulating the NF-κB/β-catenin signaling pathway,thereby suppressing inflammation and promoting gastric stem cell differentiation.These findings highlight the therapeutic potential of WMSP,providing the foundation for further clinical evaluations of WMSP in CGLSD treatment. 展开更多
关键词 gastritis liver-stomach disharmony NF-kappa B inflammation Weimishu prescription
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Yiqi Wenyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts 认领 引用
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作者 Zi-Yu Kuang Xiao-Yan Qin +3 位作者 Xin-Miao Wang Xiao-Tong Song Xiao-Yu Zhu Jie Li 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第3期183-196,共14页
BACKGROUND Disulfidptosis is a specific form of cell death that occurs in cells with high SLC7A11 expression when glucose supply is insufficient.HAase,a senescenceassociated phenotype secreted by senescent cancer-asso... BACKGROUND Disulfidptosis is a specific form of cell death that occurs in cells with high SLC7A11 expression when glucose supply is insufficient.HAase,a senescenceassociated phenotype secreted by senescent cancer-associated fibroblasts(sen-CAFs),can upregulate GLUT1 in tumor cells,thereby preventing disulfidptosis.Yiqi Wenyang Jiedu prescription(YWJP)is a Chinese herbal formula,and previous studies have shown that it can improve the clinical efficacy in the treatment of gastric cancer.AIM To investigate whether YWJP promotes gastric cancer cell disulfidptosis via HAase/GLUT1 pathway by reversing cancer-associated fibroblasts(CAFs)senescence and reducing HAase.METHODS CAFs were established using transforming growth factor-β1,and senCAFs were induced by H2O2.Senescence proportion was detected viaβ-galactosidase staining.ELISA and quantitative PCR measured interleukin-6(IL-6),interleukin-8(IL-8),hyaluronic acid,HAase,their mRNAs,NADP+/NADPH ratio,and disulfide bond levels.Western blot detected GLUT1 and disulfidptosis-related proteins.Pro-pidium iodide(PI)staining quantified dead cells.RESULTS Based on previous research methods,we successfully established the CAFs and senCAFs models.The results showed that YWJP effectively reduced the proportion of senCAFs and simultaneously decreased the secretion of IL-6,IL-8,and HAase.Under HAase culture conditions,YWJP significantly downregulated the expression of GLUT1 and disulfidptosis-related proteins(CYFIP1,Rac1,ARP2,and ARP3),increased the disulfide bond level and the proportion of PI-positive cells in MKN45 cells,and thereby promoted disulfidptosis in MKN45 cells.CONCLUSION YWJP promotes disulfidptosis in MKN45 cells by reversing the proportion of senCAFs and reducing HAase secretion. 展开更多
关键词 Gastric cancer Cancer-associated fibroblasts Yiqi Wenyang Jiedu prescription Disulfidptosis Traditional Chinese medicine
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Factors Affecting the Appropriate Angiography Prescription in Iranian Hospitals 认领 引用
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作者 Atieh Sadat Bigdeli Leila Riahi +1 位作者 Fakhreddin Hejazi Aniseh Nik Ravan 《Health Care Science》 CSCD 2026年第3期240-248,共9页
Background:Inappropriate angiography prescriptions impose substantial financial and clinical burdens on healthcare systems.This study aimed to develop a comprehensive model for appropriate angiography prescription by ... Background:Inappropriate angiography prescriptions impose substantial financial and clinical burdens on healthcare systems.This study aimed to develop a comprehensive model for appropriate angiography prescription by examining supply-and demand-side factors in public and private hospitals in Iran.Methods:Data were collected from domestic and international databases covering the period from 1998 to 2023 and analyzed through exploratory and confirmatory factor analysis.Results:Results indicated that physician density and information asymmetry were the most influential factors in the public sector,while physician income and patient insistence dominated in the private sector.Patient preferences and intolerance of uncertainty were key demand-side determinants.Conclusions:The findings support policy interventions targeting behavioral and structural drivers of inappropriate prescriptions. 展开更多
关键词 appropriate prescription clinical and non-clinical feature Iran private center public center
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Clinical efficacy of Xifeng Huashi and its effect on mental status in patients with diarrheal irritable bowel 认领 引用
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作者 Wei Wang Hui Li +4 位作者 Yu-Ping Liu Yan Chen Xiao-Ran Zhang Yan-Zhou Wang Yao-Zhou Tian 《World Journal of Psychiatry》 SCIE 2026年第2期153-162,共10页
BACKGROUND Diarrheal irritable bowel syndrome(IBS-D)is a functional gastrointestinal disorder characterized by abdominal pain accompanied by recurrent diarrhea that significantly impacts the quality of life and mental... BACKGROUND Diarrheal irritable bowel syndrome(IBS-D)is a functional gastrointestinal disorder characterized by abdominal pain accompanied by recurrent diarrhea that significantly impacts the quality of life and mental health of patients.AIM To investigate the clinical efficacy of Xifeng Huashi and its effects on the mental status of patients diagnosed with IBS-D.METHODS Data from 128 patients with IBS-D treated at the Nanjing University of Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine between June 2023 and May 2024 were divided into control and research groups,with 64 patients in each group.The control group received conventional treatment with Western medicine alone,whereas the research group was prescribed Xifeng Huashi.Differences in specific indices between the two groups were observed and compared using relevant assessment tools.RESULTS The research group showed a higher total effective rate(92.19%vs 76.56%;P=0.027)and lower traditional Chinese medicine symptom score(5.07±3.11 vs 7.38±3.68;P<0.001)than the control group.Post-treatment,the research group exhibited significantly lower levels of pro-inflammatory cytokines(tumor necrosis factor-α:18.80±4.02 ng/L vs 21.09±4.10 ng/L,P=0.002;interleukin-6:14.84±4.06 ng/L vs 19.80±4.42 ng/L,P<0.001)and higher levels of the anti-inflammatory cytokine interleukin-10(48.53±5.02 ng/L vs 46.06±4.94 ng/L,P=0.006).Moreover,markers of intestinal mucosal barrier function(diamine oxidase:6.53±2.35 ng/mL vs 7.66±2.40 ng/mL,P=0.008;D-lactate:0.18±0.04 mmol/L vs 0.20±0.06 mmol/L,P=0.004;lipopolysaccharides:44.77±8.16 pg/mL vs 48.20±8.15 pg/mL,P=0.019)were significantly improved in the research group.In addition,Selfrating Anxiety Scale(37.33±5.73 vs 39.59±6.36;P=0.036)and Self-rating Depression Scale scores(34.77±6.71 vs 38.06±6.52;P=0.006)were lower in the research group.The recurrence rate was significantly lower in the research group than in the control group(18.64%vs 40.82%,P=0.001).CONCLUSION Xifeng Huashi is effective for the treatment of IBS-D and manifests advantages in improving clinical symptoms and mental status,as well as reducing the short-term relapse rate. 展开更多
关键词 Xifeng Huashi prescription Irritable bowel syndrome Clinical efficacy Intestinal mucosal barrier Mental status
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A Pilot Study on the Accuracy of Large Language Models(ChatGPT,Google Bard,and Microsoft Copilot)for Selecting the Correct Modality for Musculoskeletal Clinical Cases According to the ACR's Appropriateness Criteria 认领 引用
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作者 Thomas Saliba Patrick Omoumi Grammatina Boitsios 《iRADIOLOGY》 CSCD 2026年第1期35-39,共5页
Background:Large language models(LLMs)are becoming more commonly used in many aspects of radiology.Some authors have previously tested the capacity of various LLMs to suggest the correct imaging modality according to ... Background:Large language models(LLMs)are becoming more commonly used in many aspects of radiology.Some authors have previously tested the capacity of various LLMs to suggest the correct imaging modality according to the guidelines of various associations,such as the American College of Radiology.This study aims to test whether free LLMs can suggest the most appropriate imaging modality in various musculoskeletal radiological cases.Methods:We tested ChatGPT 3.5,Google Bard,and Copilot(Precise)to see if they could correctly suggest the appropriate imaging modality per the American College of Radiology's Appropriateness Criteria,using clinical vignettes from the musculoskeletal section.Seventy-six vignettes were submitted to each chatbot,with the answer only being considered correct if it was the most appropriate according to the guidelines.Results:ChatGPT 3.5 was correct in 82% of cases,Bard in 66%,and Copilot in 89% of cases.Bard was unable to answer in four cases,claiming that as a LLM,it was not capable of answering the question.Conclusions:We found that all three LLMs were able to suggest the correct modality in a majority of cases.However,there was variability in the performance of the LLMs,with Copilot performing the best overall,with an accuracy of 89%. 展开更多
关键词 artificial intelligence Bard ChatGPT Copilot diagnostic guidelines imagining modality prescription
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Clinical decision and prescription generation for diarrhea in traditional Chinese medicine based on large language model 认领 引用
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作者 Jiaze Wu Hao Liang +2 位作者 Haoran Dai Hongliang Rui Baoli Liu 《Digital Chinese Medicine》 CAS CSCD 2026年第1期13-30,共18页
Objective To develop a clinical decision and prescription generation system(CDPGS)specifically for diarrhea in traditional Chinese medicine(TCM),utilizing a specialized large language model(LLM),Qwen-TCM-Dia,to standa... Objective To develop a clinical decision and prescription generation system(CDPGS)specifically for diarrhea in traditional Chinese medicine(TCM),utilizing a specialized large language model(LLM),Qwen-TCM-Dia,to standardize diagnostic processes and prescription generation.Methods Two primary datasets were constructed:an evaluation benchmark and a fine-tuning dataset consisting of fundamental diarrhea knowledge,medical records,and chain-ofthought(CoT)reasoning datasets.After an initial evaluation of 16 open-source LLMs across inference time,accuracy,and output quality,Qwen2.5 was selected as the base model due to its superior overall performance.We then employed a two-stage low-rank adaptation(LoRA)fine-tuning strategy,integrating continued pre-training on domain-specific knowledge with instruction fine-tuning using CoT-enriched medical records.This approach was designed to embed the clinical logic(symptoms→pathogenesis→therapeutic principles→prescriptions)into the model’s reasoning capabilities.The resulting fine-tuned model,specialized for TCM diarrhea,was designated as Qwen-TCM-Dia.Model performance was evaluated for disease diagnosis and syndrome type differentiation using accuracy,precision,recall,and F1-score.Furthermore,the quality of the generated prescriptions was compared with that of established open-source TCM LLMs.Results Qwen-TCM-Dia achieved peak performance compared to both the base Qwen2.5 model and five other open-source TCM LLMs.It achieved 97.05%accuracy and 91.48%F1-score in disease diagnosis,and 74.54%accuracy and 74.21%F1-score in syndrome type differentiation.Compared with existing open-source TCM LLMs(BianCang,HuangDi,LingDan,TCMLLM-PR,and ZhongJing),Qwen-TCM-Dia exhibited higher fidelity in reconstructing the“symptoms→pathogenesis→therapeutic principles→prescriptions”logic chain.It provided complete prescriptions,whereas other models often omitted dosages or generated mismatched prescriptions.Conclusion By integrating continued pre-training,CoT reasoning,and a two-stage fine-tuning strategy,this study establishes a CDPGS for diarrhea in TCM.The results demonstrate the synergistic effect of strengthening domain representation through pre-training and activating logical reasoning via CoT.This research not only provides critical technical support for the standardized diagnosis and treatment of diarrhea but also offers a scalable paradigm for the digital inheritance of expert TCM experience and the intelligent transformation of TCM. 展开更多
关键词 Diarrhea Traditional Chinese medicine Large language model Clinical decision and prescription generation Natural language processing
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An Empirical Study on the Quality Assessment and Improvement of Outpatient Prescriptions in Tertiary-Grade Class-A Hospitals under Multi-Policy Coordination 认领 引用
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作者 Bin Liu Meiling Shao +2 位作者 Jun Liang Fang Ye Li Chen 《Journal of Clinical and Nursing Research》 2026年第4期177-183,共7页
Objective:To evaluate the quality of outpatient prescriptions for Western and proprietary Chinese medicines in a tertiary hospital under the coordinated implementation of DRG/DIP payment reform,the Tertiary Hospital E... Objective:To evaluate the quality of outpatient prescriptions for Western and proprietary Chinese medicines in a tertiary hospital under the coordinated implementation of DRG/DIP payment reform,the Tertiary Hospital Evaluation Standards(2025 Edition),and the National Performance Assessment of Tertiary Public Hospitals,and to examine the effectiveness of a policy-embedded management model.Methods:A triple stratified random sampling approach(disease category-department-month)was used to collect 4,996 outpatient prescriptions from January 2024 to September 2025.A four-dimensional framework(compliance,economy,efficacy,and risk)was established.Prescription quality was assessed using a risk-scoring model and Apriori association rule analysis.Results:The overall qualification rate was 96.2%(4,807/4,996).The mean number of drugs per prescription was 2.6±0.8;antimicrobial use rate was 16.8%;essential medicines accounted for 62.5%;and drug cost proportion for key DRG/DIP disease groups was 28.3%,all meeting policy targets.Among 189 unqualified prescriptions,inappropriate medication use(38.5%)and minor omissions(48.7%)were the main issues.Association rules identified junior physicians in chronic disease management as a key risk factor(confidence>40%).Conclusion:The policy-embedded model effectively improved core prescription quality indicators to required standards.Further optimization is needed for special populations,junior physician prescribing,and intelligent system support.The proposed Assessment-Insight-Intervention closed-loop model provides a practical framework for advancing refined prescription management. 展开更多
关键词 Outpatient prescription quality DRG/DIP payment reform National Performance Assessment Antimicrobial stewardship Association rule analysis
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Hepatoprotection of Jianpi Qingre Lishi prescription(健脾清热利湿法)on non-alcoholic steatohepatitis via miRNA-27/peroxisome proliferator-activated receptor gamma axis 认领 引用
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作者 XU Mengjun YAN Zixing +3 位作者 CHEN Xi CAI Juanjuan ZHANG Haiou LIN Zhenwen 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第3期561-570,共10页
OBJECTIVE:To elucidate the molecular targets and physiological mechanisms underlying the therapeutic efficacy of Jianpi Qingre Lishi prescription(健脾清热利湿法,JQLP)in the treatment of non-alcoholic steatohepatitis(N... OBJECTIVE:To elucidate the molecular targets and physiological mechanisms underlying the therapeutic efficacy of Jianpi Qingre Lishi prescription(健脾清热利湿法,JQLP)in the treatment of non-alcoholic steatohepatitis(NASH).METHODS:This study used 120 Sprague-Dawley rats to establish six groups at random(n=20):blank control(BC),model,low-dose JQLP(L-JQLP),medium-dose JQLP(M-JQLP),high-dose JQLP(H-JQLP),and positive control(PC)groups.Rats in the BC group received a diet with methionine-and choline-sufficient(MCS),while those in the remaining groups were fed with methionineand choline-deficient(MCD)diet.Blood samples were collected for biochemical analyses and inflammatory factors determination;while liver tissues were harvested to identify the histological alterations through hematoxylin-eosin staining and oil red O staining.In addition,the levels of mi RNA-27(mi R-27)and peroxisome proliferator-activated receptorγ(PPARγ)were determined utilizing quantitative real-time polymerase chain reaction and Western blotting.RESULTS:Compared to the BC group,the model group showed no significant changes in fasting blood glucose(FBG),which was substantially reduced after both MJQLP and H-JQLP treatments.MCD diet induced a series of pathological alterations,such as extensive vacuole-like steatosis,disorganized hepatic plates,and significant inflammatory cell infiltration in liver tissues,which were dose-dependently weakened by JQLP intervention.Rats fed with MCD diet demonstrated increase in total cholesterol,triglyceride,low-density lipoprotein cholesterol,alanine aminotransferase and aspartate aminotransferase activities,but decrease in high-density lipoprotein cholesterol.JQLP treatment effectively normalized these parameters in a dose-dependent manner.Furthermore,rats with MCD diet were detected with largely secreted tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6);while JQLP intervention decreased TNF-αand IL-6 secretion,but enhanced IL-4 content.Additionally,mi R-27 upregulation and PPARγdownregulation were induced in liver tissues of rats with MCD diet,which were counteracted by JQLP treatment.CONCLUSIONS:JQLP can ameliorate NASH progression,potentially through the regulation of miR-27/PPARγaxis.JQLP may be a promising therapeutic candidate worthy of further clinical investigation for NASH treatment. 展开更多
关键词 non-alcoholic fatty liver disease PPAR gamma inflammation miRNA-27 Jianpi Qingre Lishi prescription
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Value Analysis of Modern and Contemporary Traditional Chinese Medicine Prescription Records 认领 引用
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作者 FU Yujie WANG Xi CHEN Zijie 《Chinese Medicine and Culture》 CAS 2026年第2期202-214,共13页
As important documentary sources that record the diagnostic and treatment concepts,as well as the experience of prescription medication by medical practitioners,the handwritten prescription records from modern and con... As important documentary sources that record the diagnostic and treatment concepts,as well as the experience of prescription medication by medical practitioners,the handwritten prescription records from modern and contemporary traditional Chinese medicine(TCM)practitioners are valuable original materials that carry the cultural heritage of TCM.This paper takes the handwritten prescription records of five renowned modern and contemporary TCM physicians—Zhang Jianzhai(张简斋),Qin Bowei(秦伯未),Xiao Longyou(萧龙友),Tao Zhendong(陶震东),and Chen Suhua(陈素华)—as study materials.Through the methods of literary analysis and physical verification,combined with the format,textual content,and writing style of the prescription records examples,this study explores their value and significance.The value of these notes can be categorized into five dimensions:clinical practice,learning,aesthetic education,historical materials,and cultural heritage.The purpose of this study is to reveal the research potential of handwritten TCM prescription manuscripts as interdisciplinary carriers between the history of knowledge and cultural history,to provide a historical material basis for scholars at home and abroad on the development and dissemination of TCM,and to explore new perspectives for the protection of TCM literature and the inheritance of its cultural legacy. 展开更多
关键词 Prescription manuscripts Value Example Traditional Chinese medicine
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Letter to the Editor:Xietu Hemu prescription:A novel therapeutic strategy for obesity and metabolic dysfunction-associated steatotic liver disease? 认领 引用
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作者 Alessia Provera Anteneh Nigussie Sheferaw +1 位作者 Emmanuel Kivumbi Salvatore Sutti 《World Journal of Hepatology》 2026年第7期138-141,共4页
In the recent issue of the World Journal of Hepatology,Cheng et al investigated the mechanisms by which the traditional Chinese medicine Xietu Hemu prescription(XHP)exerts therapeutic effects on metabolic dysfunction-... In the recent issue of the World Journal of Hepatology,Cheng et al investigated the mechanisms by which the traditional Chinese medicine Xietu Hemu prescription(XHP)exerts therapeutic effects on metabolic dysfunction-associated steatotic liver disease(MASLD).XHP has been shown to reduce hepatic lipid accumulation and improve metabolic parameters.In this study,serum containing XHP decreased lipid deposition in HepG2 cells and inhibited adipogenic differentiation of 3T3-L1 cells in a dose-dependent manner,reducing triglycerides,cholesterol,and adipogenic markers.UPLC-QTOF/MS/MS identified 233 XHP metabolites,mainly flavonoids,while network pharmacology revealed targets associated with lipid metabolism and obesity-related pathways,particularly AMPK signaling.Integrated analyses identified PPARG as a central hub gene.Functional experiments demonstrated that XHP enhances leptin secretion,activates AMPK phosphorylation,and suppresses lipogenic regulators,effects that were abolished by LEPR silencing.These findings suggest that XHP exerts anti-lipogenic effects through leptin-mediated AMPK activation,supporting its potential as a multitarget therapeutic for MASLD and related metabolic disorders. 展开更多
关键词 Traditional Chinese medicine Xietu Hemu prescription Therapies Metabolism Liver Metabolic dysfunction-associated steatohepatitis Metabolic dysfunctionassociated steatotic liver disease
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Qualitative Research on the Current Implementation Status and Barriers of Nurses’Non-Pharmacological Prescription Authority 认领 引用
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作者 Ying Li Yulin Lu +3 位作者 Yanxia Shang Ling Huang Panpan Cui Pingxi Yang 《Journal of Clinical and Nursing Research》 2026年第1期331-337,共7页
Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasu... Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority. 展开更多
关键词 Nurses Non-pharmacological prescription authority Implementation status Barrier factors Qualitative research
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Construction of a Formative Assessment and Stratified Practice Support Framework for Basic Table Tennis Movements in Public Physical Education Courses 认领 引用
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作者 Wanyu Zhao Yichao Zou Chunyang Zhang 《Journal of Contemporary Educational Research》 2026年第4期112-118,共7页
Addressing the practical challenges of“difficulty in diagnosis,feedback,and personalized intervention”in teaching basic table tennis movements in large-class public physical education settings,this study,guided by t... Addressing the practical challenges of“difficulty in diagnosis,feedback,and personalized intervention”in teaching basic table tennis movements in large-class public physical education settings,this study,guided by the concept of lightweight intelligent teaching,constructs a framework for formative assessment and stratified practice prescriptions for basic table tennis movements,using forms as its medium.The framework designs a three-dimensional evaluation structure of“general movement quality-movement stability-technique-specific indicators,”establishes a structured closed-loop mechanism of“diagnosis-prescription-retesting,”and achieves the operationalization of transitioning from classroom observation to personalized intervention.This paper demonstrates the design rationality of the framework from three dimensions:content validity,operational feasibility,and decision-making effectiveness.It provides a standardized and replicable paradigm for skill teaching in large-class public physical education under low-resource constraints,and also offers a complete framework foundation and theoretical basis for subsequent empirical research. 展开更多
关键词 Public physical education courses Table tennis Formative assessment Rubric Stratified practice prescription Framework construction
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Pinelliae Rhizoma:a systematic review on botany,ethnopharmacology,phytochemistry,preclinical and clinical evidence 认领 引用 被引量：4
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作者 Zuanji Liang Jinchao Wei +5 位作者 Sioi Chan Siyuan Zhang Li Xu Chenxiao Shen Zhangfeng Zhong Yitao Wang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第1期1-20,共20页
Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively util... Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively utilized in dispensing granules,classical prescriptions,and herbal formulas to treat various conditions,including cough,infection,phlegm,nausea,asthma,and inflammation.Despite numerous studies on PR and its classical prescriptions over recent decades,a comprehensive synthesis of available evidence regarding its multifunctional roles and therapeutic potential is lacking.This review aims to address this gap by examining emerging evidence from metabonomics,preclinical studies,and clinical trials,while exploring potential trends and prospects for future research.A systematic literature search was conducted across six electronic databases,including Pub Med,Web of Science,Scopus,Science Direct,Wanfang,and China National Knowledge Infrastructure,to identify relevant articles on PR published until March 2023.PR contains 107 compounds with diverse pharmacological activities,including anti-inflammatory,immune regulatory,anti-viral,anti-cancer,anti-asthma,antitussive and expectorant,antioxidant,anti-obesity,anti-atherosclerosis,antimicrobial,emetic and anti-emetic,anti-convulsant and anti-epileptic,sedative and hypnotic,learning and memory enhancement,and anti-depressant effects.Metabonomic studies suggest that raw PR may exhibit cardiotoxicity and pregnancy toxicity while showing no apparent hepatorenal toxicity.However,limited pharmacokinetic investigations on PR constrain its clinical translation.Furthermore,clinical safety data on PR is scarce,with only four clinical trials assessing its positive effects in pediatric epilepsy,nausea and vomiting,soft tissue injury,and chronic sinus tract.This review aims to enhance understanding of PR and provide valuable information and recommendations for further research and development of herbal medicine. 展开更多
关键词 Pinelliae Rhizoma Pinellia ternata Herbal medicine Classical prescription Dispensing granule
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Tailoring a traditional Chinese medicine prescription for complex diseases:A novel multi-targets-directed gradient weighting strategy 认领 引用 被引量：4
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作者 Zhe Yu Teng Li +11 位作者 Zhi Zheng Xiya Yang Xin Guo Xindi Zhang Haoying Jiang Lin Zhu Bo Yang Yang Wang Jiekun Luo Xueping Yang Tao Tang En Hu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第4期804-816,共13页
Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the characteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in... Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the characteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians,which has been a major challenge in the global acceptance and application of TCM.Therefore,a standardized TCM prescription system needs to be explored to promote its clinical application.In this study,we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation.We tested its efficacy against intracerebral hemorrhage(ICH).First,the top 100 ICH targets in the GeneCards database were screened according to their relevance scores.Then,SymMap and Traditional Chinese Medicine Systems Pharmacology(TCMSP)databases were applied to find out the target-related ingredients and ingredient-containing herbs,respectively.The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets.The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions.The absorbed components in the serum were detected.In a mouse model of ICH,the new prescription exerted multifaceted effects,including improved neurological function,as well as attenuated neuronal damage,cell apoptosis,vascular leakage,and neuroinflammation.These effects matched well with the core pathological changes in ICH.The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise,multipronged,unbiased,and standardized TCM prescriptions for complex diseases.This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts. 展开更多
关键词 Traditional Chinese medicine Prescription formulation Gradient weighting strategy Multiple targets Intracerebral hemorrhage
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Artificial Intelligence in Traditional Chinese Medicine:Multimodal Fusion and Machine Learning for Enhanced Diagnosis and Treatment Efficacy 认领 引用 被引量：4
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作者 Jie Wang Yong-mei Liu +4 位作者 Jun Li Hao-qiang He Chao Liu Yi-jie Song Su-ya Ma 《Current Medical Science》 SCIE CAS CSCD 2025年第5期1013-1022,共10页
Artificial intelligence(AI)serves as a key technology in global industrial transformation and technological restructuring and as the core driver of the fourth industrial revolution.Currently,deep learning techniques,s... Artificial intelligence(AI)serves as a key technology in global industrial transformation and technological restructuring and as the core driver of the fourth industrial revolution.Currently,deep learning techniques,such as convolutional neural networks,enable intelligent information collection in fields such as tongue and pulse diagnosis owing to their robust feature-processing capabilities.Natural language processing models,including long short-term memory and transformers,have been applied to traditional Chinese medicine(TCM)for diagnosis,syndrome differentiation,and prescription generation.Traditional machine learning algorithms,such as neural networks,support vector machines,and random forests,are also widely used in TCM diagnosis and treatment because of their strong regression and classification performance on small structured datasets.Future research on AI in TCM diagnosis and treatment may emphasize building large-scale,high-quality TCM datasets with unified criteria based on syndrome elements;identifying algorithms suited to TCM theoretical data distributions;and leveraging AI multimodal fusion and ensemble learning techniques for diverse raw features,such as images,text,and manually processed structured data,to increase the clinical efficacy of TCM diagnosis and treatment. 展开更多
关键词 Artificial intelligence Traditional Chinese medicine Machine learning Deep learning Syndromic elements Multimodal fusion Ensemble learning Clinical dignosis Prescription generation Clinical Efficacy
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