An approximate analytic model is presented to describe spatial structure of refracted electromagnetic field arising at oblique incidence of a Gaussian beam on a plane boundary of an absorbing homogeneous medium. The a...An approximate analytic model is presented to describe spatial structure of refracted electromagnetic field arising at oblique incidence of a Gaussian beam on a plane boundary of an absorbing homogeneous medium. The analytic solution is obtained by asymptotic approximation of a Fourier field integral under the condition of great beam width in comparison with a wavelength (the geometrical-optics approximation). This model can be used also for approximate simulation of refracted field in the cases of beam incidence near the critical angle on transparent or absorbing (amplifying) refracting medium, if one artificially introduces the additional absorption (amplification), whose value is proportional to the ratio of the wavelength and the effective beam width. It is shown that the analytic model reflects the general features of refracted field at total internal reflection.展开更多
Intraocular pressure(IOP)is a key parameter to diagnose glaucoma disease and assess the treatment effect of cornea after refractive surgery.Current refractive surgeries inevitably change the configuration of the corne...Intraocular pressure(IOP)is a key parameter to diagnose glaucoma disease and assess the treatment effect of cornea after refractive surgery.Current refractive surgeries inevitably change the configuration of the cornea,making it difficult to measure IOP accurately using conventional methods.The prediction method proposed in this article can accurately measure the IOP after refractive surgery.In this study,firstly,the finite element models of cornea free of IOP depicted by various vertex height,thickness,and radius are established,and the deformation of the cornea under different IOP is predicted.Based on the dataset obtained from the numerical simulations and the multi-layer perceptron neural network algorithm,two prediction models for the vertex height and thickness of the cornea free of IOP and for the configuration under IOP are developed,and a prediction method for IOP is then proposed by combining the two models.Following the similar way,two prediction models respectively for the parameters of the presumptive initial configuration of the cornea to undergo refractive surgery and for those of the cornea after surgery are constructed,and a prediction method for IOP of cornea after the surgery is presented.The validity of the prediction methods for regular IOP and that after refractive surgery is demonstrated using the clinical data from some volunteers.The proposed methods provide an efficient prediction method for regular IOP and that after refractive surgery.展开更多
Traditional intensity-based refractive index measurement methods are constrained by the classical diffraction limit and the shot noise limit,which severely restricts the improvement of measurement precision.To address...Traditional intensity-based refractive index measurement methods are constrained by the classical diffraction limit and the shot noise limit,which severely restricts the improvement of measurement precision.To address this issue,a novel quantum measurement scheme integrating entangled coherent states(ECS)and parity detection(PD)is proposed.Taking advantage of the non-classical correlation of quantum entanglement,the scheme constructs a dual-mode entangled coherent state light source and realizes high-fidelity signal demodulation through a customized parity detection system.Theoretical derivation and numerical simulation results demonstrate that the measurement resolution of the proposed scheme breaks through the Rayleigh limit,achieving a■-fold improvement compared with the traditional coherent state measurement method in the full loss range.In lossless scenarios and cases with loss rates below 10%,the sensitivity surpasses the shot noise limit.Finally,the experimental challenges are also elaborated in detail.This quantum measurement architecture provides a new technical pathway for precision optical detection,biosensing,and other fields,exhibiting significant practical value and broad application prospects.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were perfor...Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were performed to investigate property changes between uncoated and coated SSA particles to assess the effect of organic coating on the surface chemistry and optical properties of nascent SSA.Stearic acid,oleic acid and mixed fatty acid were used as a proxy for coating materials and applied to aerosols produced by SSA generator.We found that the geometric mean diameter of SSA particles increased with increasing concentration of the fatty acid vapor due to higher heating temperatures,suggesting the formation of thicker coatings.Characterization by Fourier transform infrared spectroscopy and transmission electron microscope demonstrated that the SSA surface was coated with an organic coating of fatty acids,which gave the SSA a core–shell morphology.Furthermore,optical measurements by photo-acoustic extinctiometer at 375 nm revealed significantly enhanced light scattering efficiency and complex refractive index from fatty acid-coated SSA particles.The current results suggest that the fatty acid coating changes the diameter and surface composition of SSA particles,which may further impact their optical properties.It is therefore necessary to accurately characterize the overall properties of SSA particles carrying organic coatings due to condensing fatty acid vapor to reveal their overall impact on climate.展开更多
Terahertz(THz)waves exhibit distinctive advantages for biomedical sensing,while metasurface technology offers an effective route toward high-performance THz sensors.A high-sensitivity THz metasurface absorber sensor f...Terahertz(THz)waves exhibit distinctive advantages for biomedical sensing,while metasurface technology offers an effective route toward high-performance THz sensors.A high-sensitivity THz metasurface absorber sensor for biological sample detection is proposed and numerically investigated.The sensor adopts a metal-insulator-metal(MIM)configuration,in which four centrosymmetrically arranged split metal rings form a multimode resonator.Copper is employed as the metallic layer,and PTFE is selected as the dielectric spacer.The electromagnetic response of the sensor is analyzed using CST Microwave Studio based on the FIT.Simulation results demonstrate that the proposed sensor supports two independent near-perfect absorption resonances at 3.1564 THz and 3.724 THz,with peak absorption rates of 99.75%and 99.84%,respectively.Owing to the strong localized field enhancement and multimode coupling effects,the resonant frequencies exhibit pronounced sensitivity to variations in the surrounding refractive index.Within the typical refractive-index range of biomedical samples,the maximum sensitivity reaches 241 GHz/RIU,accompanied by a maximum figure of merit(FOM)of 8.02.In addition,the absorption performance remains above 99%for polarization angles from 0°to 90°,with negligible resonance shift,indicating excellent polarization insensitivity.Benefiting from the use of low-dielectric-constant materials,the proposed sensor showed good material compatibility and portability.These results suggested that the designed metasurface absorber provided a promising platform for high-sensitivity terahertz biosensing applications.展开更多
Black carbon(BC)mixed with non-BC components strongly absorbs visible light and leads to uncertainty in assessing the absorption enhancement(Eabs)and thus radiative forcing.Traditional Single-Particle Soot Photomet...Black carbon(BC)mixed with non-BC components strongly absorbs visible light and leads to uncertainty in assessing the absorption enhancement(Eabs)and thus radiative forcing.Traditional Single-Particle Soot Photometer(SP2)combined with the leading-edge only fitting(the only-SP2 method)derives BC’s mixing states through Mie scattering calculations.However,errors exist in retrieved optical diameter(Dopt)and MRdue to the assumption of the ideal spherical core-shell structure and the selection of the calculation parameters like density and refractive index(RI)of the components.Here,we employed a custom-developed tandem CPMA-SP2 system,which classifies fixed-mass BC to characterize the mixing state,then compared with the only-SP2 method in quantifying the mixing state and Eabs.The field measurements show that the SP2 demonstrates variability in assessing the mixing state of BC in different aging states.The thickly-coated particles with small core approaching the internally mixed state are more sensitive to the change of calculated RI.The Doptdecreases with the RI increasing,indicating that this method accurately measures both Doptand Eabswhen a reasonable refractive index is selected for calculation.However,for thinly-coated particles with moderate or large core,this method results in significant deviations in the computed Eabs(errors up to 15%).These deviations may be caused by the various shapes of BC and systematic errors.Our results provide valuable insights into the accuracy of the SP2-retrieved Doptand MRbased on Mie calculations and highlight the importance of employing advanced techniques for further assessment of BC’s mixing state.展开更多
AIM:To evaluate the efficacy of the total computer vision syndrome questionnaire(CVS-Q)score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors.METHODS:A...AIM:To evaluate the efficacy of the total computer vision syndrome questionnaire(CVS-Q)score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors.METHODS:A total of 141 healthy computer users underwent comprehensive clinical visual function assessments,including evaluations of refractive errors,accommodation(amplitude of accommodation,positive relative accommodation,negative relative accommodation,accommodative accuracy,and accommodative facility),and vergence(phoria,positive and negative fusional vergence,near point of convergence,and vergence facility).Total CVS-Q scores were recorded to explore potential associations between symptom scores and the aforementioned clinical visual function parameters.RESULTS:The cohort included 54 males(38.3%)with a mean age of 23.9±0.58y and 87 age-matched females(61.7%)with a mean age of 23.9±0.53y.The multiple regression model was statistically significant[R²=0.60,F=13.28,degrees of freedom(DF=17122,P<0.001].This indicates that 60%of the variance in total CVS-Q scores(reflecting reported symptoms)could be explained by four clinical measurements:amplitude of accommodation,positive relative accommodation,exophoria at distance and near,and positive fusional vergence at near.CONCLUSION:The total CVS-Q score is a valid and reliable tool for predicting the presence of various nonstrabismic binocular vision anomalies and refractive errors in symptomatic computer users.展开更多
Gradient refractive index(GRIN)metalenses are increasingly valued in high-frequency communication due to their exceptional radiation performance.Ceramics with high dielectric constants and low dielectric losses are id...Gradient refractive index(GRIN)metalenses are increasingly valued in high-frequency communication due to their exceptional radiation performance.Ceramics with high dielectric constants and low dielectric losses are ideal candidates for GRIN metalenses.Digital light processing(DLP)3D printing provides a feasible and efficient approach for manufacturing ceramic GRIN metalenses.However,the scattering of ultraviolet(UV)light by ceramic particles in the slurry reduces the printing accuracy of DLP technology,making it difficult to achieve the intricate structural features required for GRIN metalenses in high-frequency communication.In this work,we propose an approach to improve printing accuracy by optimizing the ceramic slurry composition and implementing a dimensional compensation design strategy.Utilizing geometric optics and the S-parameter inversion method,we design a GRIN metalens consisting of two distinct types of subwavelength unit cells(Y-shaped and circular hole geometries)with a minimum feature size of 160μm.Through a refined slurry formulation and precise design parameter compensation,high-fidelity ceramic GRIN metalenses are successfully fabricated.The fabricated metalens exhibits a maximum gain enhancement of 18.4 dBi and a deflection angle of±30°over a bandwidth of 37.84% in the W-band(75-110 GHz).The highly directional far-field beam radiation and efficient beam steering capabilities highlight the potential of ceramic GRIN metalenses for applications in satellite communications,radar systems,and other high-frequency technologies.展开更多
Surface polaritons,as surface electromagnetic waves propagating along the surface of a medium,have played a crucial role in enhancing photonic spin Hall effect(PSHE)and developing highly sensitive refractive index(RI)...Surface polaritons,as surface electromagnetic waves propagating along the surface of a medium,have played a crucial role in enhancing photonic spin Hall effect(PSHE)and developing highly sensitive refractive index(RI)sensors.Among them,the traditional surface plasmon polariton(SPP)based on noble metals limits its application beyond the near-infrared(IR)regime due to the large negative permittivity and optical losses.In this contribution,we theoretically proposed a highly sensitive PSHE sensor with the structure of Ge prism-SiC-Si:InAs-sensing medium,by taking advantage of the hybrid surface plasmon phonon polariton(SPPhP)in mid-IR regime.Here,heavily Si-doped InAs(Si:InAs)and SiC excite the SPP and surface phonon polariton(SPhP),and the hybrid SPPhP is realized in this system.More importantly,the designed PSHE sensor based on this SPPhP mechanism achieves the multi-stage RI measurements from 1.00025-1.00225 to 1.70025-1.70225,and the maximal intensity sensitivity and angle sensitivity can be up to 9.4×104μm/RIU and245°/RIU,respectively.These findings provide a new pathway for the enhancement of PSHE in mid-IR regime,and offer new opportunities to develop highly sensitive RI sensors in multi-scenario applications,such as harmful gas monitoring and biosensing.展开更多
AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional...AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional survey of ocular symptoms and clinical eye examinations were performed in a sample of 35 rural primary schools in the semi-arid region of Kajiado West sub-county in S.W.Kenya,amongst a seminomadic tribe(Maasai).Students in Grades 1-8 were included.Visual acuity was measured using the Snellen“tumbling E”chart at 6 m.Children with symptoms of refractive error underwent non-cycloplegic refraction.RESULTS:A total of 2036 children(1084 males)between the ages of 4-20y were examined.Conjunctival actinic changes were present in 22%(442/2036).Nine cases were seen with a potential squamous carcinoma.No overt classical ocular signs of vitamin A deficiency were noted,although 181(8.9%)children complained of nyctalopia.Three hundred thirty-six(16.5%)children had a visual acuity worse than 6/12 in either eye,were unable to read N10 near text at 40 cm or had symptoms suggestive of refractive error.Refractive data led to an estimate of hyperopia of+1.00 D or more in 3.9%and of myopia of-0.50 D or more in either eye in 3.0%of the study population.CONCLUSION:Solar exposure-and dust-related conjunctival pathology is common.As this may develop into potentially sight-or even life-threatening conditions,it warrants further study,and preventive strategies may be needed.Complaints of nyctalopia were common and could suggest vitamin A deficiency.The prevalence of refractive errors is low in this rural African population.展开更多
AIM:To evaluate the long-term refractive and visual outcomes in infants with retinopathy of prematurity(ROP)treated with intravitreal bevacizumab(IVB),laser photocoagulation(LPC),or combined IVB+LPC therapy,and to ass...AIM:To evaluate the long-term refractive and visual outcomes in infants with retinopathy of prematurity(ROP)treated with intravitreal bevacizumab(IVB),laser photocoagulation(LPC),or combined IVB+LPC therapy,and to assess disease severity on refractive development over five years.METHODS:This retrospective cohort study analyzed data from infants diagnosed with ROP between 2013 and 2018.Patients were categorized into four groups:IVB(n=44),LPC(n=41),IVB+LPC(n=17),and regressed ROP(RROP,n=50).A subgroup analysis was performed for Type 1 ROP and aggressive ROP(AROP).Primary outcomes included spherical equivalent(SE),astigmatism,and visual acuity(logMAR),measured at 6-month intervals up to 60mo.RESULTS:The study included 152 patients(76 females).The mean birth weight was 1256.1±555.6 g,and the mean week of birth was 29.1±2.9wk.RROP infants had the highest SE,closest to emmetropia.The IVB+LPC group showed the most significant myopic shift compared to other groups(P<0.05).In Type 1 ROP,SE was lower in the IVB+LPC group initially,but by 60mo,the difference was not significant.Astigmatism was higher in the LPC group at later time points(36–60mo).However,no differences in visual acuity were observed at the final follow-up among treatment groups.CONCLUSION:Refractive outcomes vary more in Type 1 ROP than AROP.IVB+LPC results in greater myopia;LPC is associated with increased astigmatism.Individualized refractive follow-up is essential,particularly for Type 1 ROP.展开更多
AIM:To evaluate the ability of six advanced large language models(LLMs)—in providing accurate,comprehensive,and readable patient education on corneal refractive surgeries[laser in-situ keratomileusis(LASIK),keratoref...AIM:To evaluate the ability of six advanced large language models(LLMs)—in providing accurate,comprehensive,and readable patient education on corneal refractive surgeries[laser in-situ keratomileusis(LASIK),keratorefractive lenticule extraction(KLEx),and photorefractive keratectomy(PRK)]in both English and Chinese.METHODS:This is a cross-sectional,comparative study.Twenty-six questions,compiled from authoritative ophthalmologic sources and covering four domains(procedure basics and eligibility;safety,risks and longterm stability;recovery and postoperative experience;and practical concerns),were administered in both English and Chinese via fresh chat sessions with each LLM,respectively.Five performance metrics were evaluated:accuracy,comprehensiveness,word count,readability,and reproducibility,using appropriate statistical tests.RESULTS:OpenAI o1 and DeepSeek-R1 consistently achieved the highest accuracy and most comprehensive responses,significantly outperforming ChatGPT-4o,Gemini Advanced,Claude Sonnet,and Tongyi Qwen(Friedman P<0.001).Although overall accuracy and comprehensiveness were similar across languages,Chinese responses were significantly longer.Readability varied among the models,with Claude Sonnet generally producing the most readable English texts.Reproducibility analysis revealed moderate consistency,reflecting inherent variability in outputs to identical prompts.CONCLUSION:Reasoning-augmented LLMs,particularly OpenAI o1 and DeepSeek-R1,demonstrate superior performance in delivering bilingual patient education for corneal refractive surgery,with high accuracy and comprehensiveness.However,variations in response length,readability,and reproducibility indicate that further refinement is necessary before these tools can be reliably integrated into clinical practice.展开更多
The nonlinear Schrödinger’s equation(NLSE)with Kudryashov’s refractive index which describes the wave dynamics through optical fibers is investigated.The literature review of the previous works are introduced t...The nonlinear Schrödinger’s equation(NLSE)with Kudryashov’s refractive index which describes the wave dynamics through optical fibers is investigated.The literature review of the previous works are introduced to exhibit the motivation and the importance of this work.In addition,the integration technique of the improved modified extended tanh function scheme is applied on the investigated model to derive various and novel solutions.These solutions are bright,dark and singular solitons.In addition,Weierstrass elliptic,singular periodic,exponential and rational type solutions are derived.It needs to be noted that this governing model can be useful for description of physical processes in nonlinear optics and also the results revealed for the equation are new and originally reported in the present work for the first time.Moreover,the graphical representations of some solutions are depicted to show the powerful and the characteristics of them.展开更多
As co-packaged optics(CPO)integrates photonic chips and electronic dies together,accurate and non-destructive post-fabrication characterization of waveguide parameters—width,thickness,and the refractive indices of bo...As co-packaged optics(CPO)integrates photonic chips and electronic dies together,accurate and non-destructive post-fabrication characterization of waveguide parameters—width,thickness,and the refractive indices of both core and cladding—becomes critical,because even minute index deviations are amplified in dense interconnects and directly impair the signal integrity and energy efficiency of CPO modules.We take the material refractive index as an example and demonstrate an effective approach for non-destructive parameter extraction of the as-fabricated optical waveguide with a single photonic crystal ring resonator.By lifting the degeneracy of the symmetric and anti-symmetric resonant peak,this single structure suffices to determine the core and clad indices rapidly with high precision.We successfully applied the extracted parameter of the refractive indices to validate the optical transmission of the indexesensitive wavelength division multiplexer device.Our approach has provided a facile solution for postfabrication device parameter evaluation and is readily extendable to geometric parameters.展开更多
Refractive surgery can unmask or accelerate transforming growth factor-β-induced(TGFBI)-related corneal dystrophies that are undetectable by routine slit-lamp examination,creating a clear need for a rapid,standardize...Refractive surgery can unmask or accelerate transforming growth factor-β-induced(TGFBI)-related corneal dystrophies that are undetectable by routine slit-lamp examination,creating a clear need for a rapid,standardized,preoperative genetic screening.We developed a multiplex,allele-specific real-time quantitative polymerase chain reaction(qPCR)panel targeting five high-frequency TGFBI hotspots(R124C/L/H,R555W/Q)and built a statistics-driven analytical framework to optimize assay decisions.Receiver operating characteristic(ROC)analysis defined locus-specific cycle threshold(CT)cut-offs that were harmonized to a single decision threshold(CT=36)to simplify deployment.Analytical sensitivity was established by Probit modeling of serial two-fold dilutions,and confirmed by≥20 replicates per level.In a 158-sample validation set(38 mutation-positive;120 negative),qPCR agreed perfectly with Sanger sequencing(Cohen’s kappa coefficient(κ)=1.0).Probit analysis yielded locus-specific limit of detection(LoD)values ranging from 0.035 to 0.200 ng/μL;at 0.200 ng/μL,the detection rate was over 95%.Repeatability and intermediate precision were high(CT coefficient of variation(CV)0.34%-1.21%).No cross-reactivity was observed against non-target TGFBI variants or other ophthalmic genes,and interference from blood,oral florainse,or toothpaste produced small,bounded shifts(approximately−7.8%to+2.8%).Calibration with serial dilutions demonstrated linear CT-log(copy)relationships suitable for routine quality control.Prospective screening of 10055 refractive surgery candidates identified six TGFBI carriers(0.06%)harboring R124H(including one homozygote),R124L,R124C,or R555W mutation,all confirmed by Sanger sequencing.This study established a clinically applicable,statistically optimized multiplex qPCR platform that integrated ROC-derived cut-offs and Probit-defined LoD with rigorous evaluations of precision,specificity,and robustness,enabling large-scale population implementation.Positive screening results guide clinical decision-making through a standardized post-screening workflow,and the targeted hotspot screening strategy serves as a cost-effective first-tier high-throughput approach for preoperative risk assessment.The framework provides a transparent,reproducible path to standardize preoperative TGFBI screening and reduce iatrogenic risk in refractive surgery candidates.展开更多
In this paper,we propose and numerically characterize the optical characteristics of a high-sensitivity dual-polarization four-channel surface plasmon resonance(SPR)refractive index sensor with wide detection range an...In this paper,we propose and numerically characterize the optical characteristics of a high-sensitivity dual-polarization four-channel surface plasmon resonance(SPR)refractive index sensor with wide detection range and high linearity based on photonic crystal fiber(PCF).Four light transmission channels are constructed by using big air holes.The small rectangular air hole in the center of the fiber core is used to add asymmetry.We use gold plasma material to achieve better sensing performance.A thin film of TiO2 is placed on the PCF surface,which assists gold in the adhesion on PCF.The maximum wavelength sensitivity of the sensor can reach 20000 nm/RIU in both x and y polarization modes.While the maximum wavelength resolution of the sensor is 5×10-6 RIU.The average wavelength sensitivity reached 15900 nm/RIU and 15800 nm/RIU in x and y polarization modes.The sensor features R2=0.9969/R2=0.9966 high linear performance in x and y polarization modes and the maximum figure of merit(FOM)values of 509.13 RIU-1/489.63 RIU-1 in x and y polarization modes.Besides,the sensor's detection range is 1.26–1.36,which is a wide refractive index detection range.展开更多
Fiber-optic sensing technology has the advantages of passivity, anti-electromagnetic interference, longdistancemeasurement, high sensitivity and high accuracy, small size, and adaptability to harsh environments such a...Fiber-optic sensing technology has the advantages of passivity, anti-electromagnetic interference, longdistancemeasurement, high sensitivity and high accuracy, small size, and adaptability to harsh environments such ashigh-vacuum, high-pressure, and strong magnetic fields compared with the traditional electrical sensing technology.However, with the increasing application requirements, how to further improve the sensitivity of fiber-optic sensors,extend the detection limit and improve the maintenance-free capability has become one of the core issues of thecurrent research. This paper reviews the principle, preparation, and application of fiber-optic microstructured sensingbased on abrupt field type. It specifically outlines the development and applications of micro-nano optical fibers,photonic crystal optical fibers, optical fiber gratings and structured optical fibers, and lists the main preparationmethods of two types of micro-nano optical fibers from the basic theory of optical fiber microstructured sensordevices.展开更多
AIM:To compare the clinical outcomes of the current V4c model of the myopic implantable Collamer lens(ICL)with those of laser in situ keratomileusis(LASIK)for the correction of myopia ranging from−2.0 to−18.0 diopters...AIM:To compare the clinical outcomes of the current V4c model of the myopic implantable Collamer lens(ICL)with those of laser in situ keratomileusis(LASIK)for the correction of myopia ranging from−2.0 to−18.0 diopters(D).METHODS:This prospective,non-randomized study enrolled participants who underwent either LASIK or implantation of the ICL V4c at Bolor Melmii Eye Hospital.In the LASIK group,participants received Intralase LASIK(I-LASIK)using the Intralase FS-200 femtosecond laser and the MEL-80 excimer laser.Each group comprised the same number of participants and eyes(38 participants,73 eyes).RESULTS:A total of 146 eyes from 76 participants were analyzed.Among the LASIK group,76.3%were female,with a mean age at surgery of 29.76±5.95y(range,20–43y).In the ICL group,92.1%were female,with a mean age of 31.59±8.32y(range,20–49y).Preoperative best-corrected visual acuity(BCVA)did not differ significantly between the LASIK and ICL groups(P=0.68).Postoperatively,the ICL group consistently demonstrated better BCVA(20/20 or better)at all follow-up points,with statistically significant differences observed at 1d(56.2%vs 30.1%,P=0.003)and 3mo(54.8%vs 32.9%,P=0.012).The mean BCVA improvement also favored the ICL group for up to 6mo postoperatively.A higher proportion of eyes in the ICL group achieved uncorrected distance visual acuity(UDVA)of 20/20 or better at 1mo(50.7%vs 41.1%,P=0.319)and 6mo(57.5%vs 43.8%,P=0.136),although these differences were not statistically significant.Predictability was comparable between the groups,except at 6mo,where fewer ICL-treated eyes were within±0.5 D of the intended correction(49.3%vs 64.4%,P=0.094).Nevertheless,both groups achieved identical outcomes within±1.0 D(90.4%,P=1.000).Between 1 and 6mo,78.1%of eyes in the ICL group showed a change in spherical equivalent refraction of no more than 0.5 D,compared to 65.8%in the LASIK group.Refraction stability,defined as a change of less than 1.0 D,remained good in both groups throughout all followup periods.CONCLUSION:Both LASIK and ICL implantation leads to significant improvements in visual outcomes,with early postoperative gains observed in both groups.However,the ICL group demonstrates greater long-term improvement in BCVA compared to the LASIK group,particularly among participants with higher degrees of myopia.Visual outcomes in both groups stabilized by 6mo postoperatively.展开更多
Keratorefractive surgery is typically performed to correct refractive errors,resulting in good postoperative outcomes.Certain conditions,such as autoimmune diseases,metabolic diseases like diabetes mellitus(DM),and th...Keratorefractive surgery is typically performed to correct refractive errors,resulting in good postoperative outcomes.Certain conditions,such as autoimmune diseases,metabolic diseases like diabetes mellitus(DM),and the use of some drugs,may be absolutely or relatively contraindicated for refractive surgery.DM is a multisystemic disorder affecting various organs and can result in retinopathy,nephropathy,and neuropathy.Persistent hyperglycemia leads to various pathophysiological changes that can alter the biomechanical profile and the wound healing process of the cornea.Proper patient counselling,optimizing blood glucose levels,and frequent follow-up visits to monitor and manage potential complications,such as dry eye,non-healing epithelial defects,and neurotrophic keratitis,are essential for refractive surgeons.Laser-assisted in situ keratomileusis is preferred over photorefractive keratectomy due to its faster healing process.Cataract surgery in people with diabetes warrants various preoperative,intraoperative,and postoperative considerations for the best visual outcomes.This review focuses on the current evidence pertaining to various structural and functional corneal changes occurring in diabetics and their impact on keratorefractive procedures,thus providing a unified,clinically oriented framework to guide refractive surgeons in risk stratification,procedure selection,and postoperative management in patients with DM.展开更多
摘要An approximate analytic model is presented to describe spatial structure of refracted electromagnetic field arising at oblique incidence of a Gaussian beam on a plane boundary of an absorbing homogeneous medium. The analytic solution is obtained by asymptotic approximation of a Fourier field integral under the condition of great beam width in comparison with a wavelength (the geometrical-optics approximation). This model can be used also for approximate simulation of refracted field in the cases of beam incidence near the critical angle on transparent or absorbing (amplifying) refracting medium, if one artificially introduces the additional absorption (amplification), whose value is proportional to the ratio of the wavelength and the effective beam width. It is shown that the analytic model reflects the general features of refracted field at total internal reflection.
基金supported by Central guidance for local scientific and technological development funding projects(Grant No.2024ZY01057)。
摘要Intraocular pressure(IOP)is a key parameter to diagnose glaucoma disease and assess the treatment effect of cornea after refractive surgery.Current refractive surgeries inevitably change the configuration of the cornea,making it difficult to measure IOP accurately using conventional methods.The prediction method proposed in this article can accurately measure the IOP after refractive surgery.In this study,firstly,the finite element models of cornea free of IOP depicted by various vertex height,thickness,and radius are established,and the deformation of the cornea under different IOP is predicted.Based on the dataset obtained from the numerical simulations and the multi-layer perceptron neural network algorithm,two prediction models for the vertex height and thickness of the cornea free of IOP and for the configuration under IOP are developed,and a prediction method for IOP is then proposed by combining the two models.Following the similar way,two prediction models respectively for the parameters of the presumptive initial configuration of the cornea to undergo refractive surgery and for those of the cornea after surgery are constructed,and a prediction method for IOP of cornea after the surgery is presented.The validity of the prediction methods for regular IOP and that after refractive surgery is demonstrated using the clinical data from some volunteers.The proposed methods provide an efficient prediction method for regular IOP and that after refractive surgery.
摘要Traditional intensity-based refractive index measurement methods are constrained by the classical diffraction limit and the shot noise limit,which severely restricts the improvement of measurement precision.To address this issue,a novel quantum measurement scheme integrating entangled coherent states(ECS)and parity detection(PD)is proposed.Taking advantage of the non-classical correlation of quantum entanglement,the scheme constructs a dual-mode entangled coherent state light source and realizes high-fidelity signal demodulation through a customized parity detection system.Theoretical derivation and numerical simulation results demonstrate that the measurement resolution of the proposed scheme breaks through the Rayleigh limit,achieving a■-fold improvement compared with the traditional coherent state measurement method in the full loss range.In lossless scenarios and cases with loss rates below 10%,the sensitivity surpasses the shot noise limit.Finally,the experimental challenges are also elaborated in detail.This quantum measurement architecture provides a new technical pathway for precision optical detection,biosensing,and other fields,exhibiting significant practical value and broad application prospects.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
摘要AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
基金supported by the National Natural Science Foundation of China(No.22376121)Hainan Provincial Natural Science Foundation of China(No.425MS036).
摘要Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were performed to investigate property changes between uncoated and coated SSA particles to assess the effect of organic coating on the surface chemistry and optical properties of nascent SSA.Stearic acid,oleic acid and mixed fatty acid were used as a proxy for coating materials and applied to aerosols produced by SSA generator.We found that the geometric mean diameter of SSA particles increased with increasing concentration of the fatty acid vapor due to higher heating temperatures,suggesting the formation of thicker coatings.Characterization by Fourier transform infrared spectroscopy and transmission electron microscope demonstrated that the SSA surface was coated with an organic coating of fatty acids,which gave the SSA a core–shell morphology.Furthermore,optical measurements by photo-acoustic extinctiometer at 375 nm revealed significantly enhanced light scattering efficiency and complex refractive index from fatty acid-coated SSA particles.The current results suggest that the fatty acid coating changes the diameter and surface composition of SSA particles,which may further impact their optical properties.It is therefore necessary to accurately characterize the overall properties of SSA particles carrying organic coatings due to condensing fatty acid vapor to reveal their overall impact on climate.
基金supported by the National Natural Science Foundation of China(Nos.62301509,62405293)the Key Research and Development Program of Shanxi Province(No.202302030201001)+1 种基金the Fundamental Research Program of Shanxi Province(No.202303021212191)General Project of China Postdoctoral Science Foundation(No.2025M770537).
摘要Terahertz(THz)waves exhibit distinctive advantages for biomedical sensing,while metasurface technology offers an effective route toward high-performance THz sensors.A high-sensitivity THz metasurface absorber sensor for biological sample detection is proposed and numerically investigated.The sensor adopts a metal-insulator-metal(MIM)configuration,in which four centrosymmetrically arranged split metal rings form a multimode resonator.Copper is employed as the metallic layer,and PTFE is selected as the dielectric spacer.The electromagnetic response of the sensor is analyzed using CST Microwave Studio based on the FIT.Simulation results demonstrate that the proposed sensor supports two independent near-perfect absorption resonances at 3.1564 THz and 3.724 THz,with peak absorption rates of 99.75%and 99.84%,respectively.Owing to the strong localized field enhancement and multimode coupling effects,the resonant frequencies exhibit pronounced sensitivity to variations in the surrounding refractive index.Within the typical refractive-index range of biomedical samples,the maximum sensitivity reaches 241 GHz/RIU,accompanied by a maximum figure of merit(FOM)of 8.02.In addition,the absorption performance remains above 99%for polarization angles from 0°to 90°,with negligible resonance shift,indicating excellent polarization insensitivity.Benefiting from the use of low-dielectric-constant materials,the proposed sensor showed good material compatibility and portability.These results suggested that the designed metasurface absorber provided a promising platform for high-sensitivity terahertz biosensing applications.
基金supported by the National Key Research and Development Program of China(No.2022YFC3701000)the National Natural Science Foundation of China(No.42375101)。
摘要Black carbon(BC)mixed with non-BC components strongly absorbs visible light and leads to uncertainty in assessing the absorption enhancement(Eabs)and thus radiative forcing.Traditional Single-Particle Soot Photometer(SP2)combined with the leading-edge only fitting(the only-SP2 method)derives BC’s mixing states through Mie scattering calculations.However,errors exist in retrieved optical diameter(Dopt)and MRdue to the assumption of the ideal spherical core-shell structure and the selection of the calculation parameters like density and refractive index(RI)of the components.Here,we employed a custom-developed tandem CPMA-SP2 system,which classifies fixed-mass BC to characterize the mixing state,then compared with the only-SP2 method in quantifying the mixing state and Eabs.The field measurements show that the SP2 demonstrates variability in assessing the mixing state of BC in different aging states.The thickly-coated particles with small core approaching the internally mixed state are more sensitive to the change of calculated RI.The Doptdecreases with the RI increasing,indicating that this method accurately measures both Doptand Eabswhen a reasonable refractive index is selected for calculation.However,for thinly-coated particles with moderate or large core,this method results in significant deviations in the computed Eabs(errors up to 15%).These deviations may be caused by the various shapes of BC and systematic errors.Our results provide valuable insights into the accuracy of the SP2-retrieved Doptand MRbased on Mie calculations and highlight the importance of employing advanced techniques for further assessment of BC’s mixing state.
基金Supported by Ongoing Research Funding Program(ORFFT-2025-054-1),King Saud University,Riyadh,Saudi Arabia.
摘要AIM:To evaluate the efficacy of the total computer vision syndrome questionnaire(CVS-Q)score as a predictive tool for identifying individuals with symptomatic binocular vision anomalies and refractive errors.METHODS:A total of 141 healthy computer users underwent comprehensive clinical visual function assessments,including evaluations of refractive errors,accommodation(amplitude of accommodation,positive relative accommodation,negative relative accommodation,accommodative accuracy,and accommodative facility),and vergence(phoria,positive and negative fusional vergence,near point of convergence,and vergence facility).Total CVS-Q scores were recorded to explore potential associations between symptom scores and the aforementioned clinical visual function parameters.RESULTS:The cohort included 54 males(38.3%)with a mean age of 23.9±0.58y and 87 age-matched females(61.7%)with a mean age of 23.9±0.53y.The multiple regression model was statistically significant[R²=0.60,F=13.28,degrees of freedom(DF=17122,P<0.001].This indicates that 60%of the variance in total CVS-Q scores(reflecting reported symptoms)could be explained by four clinical measurements:amplitude of accommodation,positive relative accommodation,exophoria at distance and near,and positive fusional vergence at near.CONCLUSION:The total CVS-Q score is a valid and reliable tool for predicting the presence of various nonstrabismic binocular vision anomalies and refractive errors in symptomatic computer users.
基金financial support by the National Key Research and Development Program of China(No.2023YFB4605400)the National Natural Science Foundation of China(No.12472152)the Department of Science and Technology of Guangdong Province(No.2019QN01Z438)。
摘要Gradient refractive index(GRIN)metalenses are increasingly valued in high-frequency communication due to their exceptional radiation performance.Ceramics with high dielectric constants and low dielectric losses are ideal candidates for GRIN metalenses.Digital light processing(DLP)3D printing provides a feasible and efficient approach for manufacturing ceramic GRIN metalenses.However,the scattering of ultraviolet(UV)light by ceramic particles in the slurry reduces the printing accuracy of DLP technology,making it difficult to achieve the intricate structural features required for GRIN metalenses in high-frequency communication.In this work,we propose an approach to improve printing accuracy by optimizing the ceramic slurry composition and implementing a dimensional compensation design strategy.Utilizing geometric optics and the S-parameter inversion method,we design a GRIN metalens consisting of two distinct types of subwavelength unit cells(Y-shaped and circular hole geometries)with a minimum feature size of 160μm.Through a refined slurry formulation and precise design parameter compensation,high-fidelity ceramic GRIN metalenses are successfully fabricated.The fabricated metalens exhibits a maximum gain enhancement of 18.4 dBi and a deflection angle of±30°over a bandwidth of 37.84% in the W-band(75-110 GHz).The highly directional far-field beam radiation and efficient beam steering capabilities highlight the potential of ceramic GRIN metalenses for applications in satellite communications,radar systems,and other high-frequency technologies.
基金Project supported by the National Natural Science Foundation of China(Grant No.12175107)the Qing Lan Project of Jiangsu Province+2 种基金the Hua Li Talents Program of Nanjing University of PostsTelecommunications,Natural Science Foundation of Nanjing Vocational University of Industry Technology(Grant No.YK22-02-08)the Fund from the Research Center of Industrial Perception and Intelligent Manufacturing Equipment Engineering of Jiangsu Province,China(Grant No.ZK21-05-09)。
摘要Surface polaritons,as surface electromagnetic waves propagating along the surface of a medium,have played a crucial role in enhancing photonic spin Hall effect(PSHE)and developing highly sensitive refractive index(RI)sensors.Among them,the traditional surface plasmon polariton(SPP)based on noble metals limits its application beyond the near-infrared(IR)regime due to the large negative permittivity and optical losses.In this contribution,we theoretically proposed a highly sensitive PSHE sensor with the structure of Ge prism-SiC-Si:InAs-sensing medium,by taking advantage of the hybrid surface plasmon phonon polariton(SPPhP)in mid-IR regime.Here,heavily Si-doped InAs(Si:InAs)and SiC excite the SPP and surface phonon polariton(SPhP),and the hybrid SPPhP is realized in this system.More importantly,the designed PSHE sensor based on this SPPhP mechanism achieves the multi-stage RI measurements from 1.00025-1.00225 to 1.70025-1.70225,and the maximal intensity sensitivity and angle sensitivity can be up to 9.4×104μm/RIU and245°/RIU,respectively.These findings provide a new pathway for the enhancement of PSHE in mid-IR regime,and offer new opportunities to develop highly sensitive RI sensors in multi-scenario applications,such as harmful gas monitoring and biosensing.
基金Supported by Vision International Eye Missions-USA,“One Drop for All”,Italy,and Private Donors in the Netherlands.
摘要AIM:To ascertain the pattern of ocular morbidity in a population of primary school children in rural Kenya as it is a prerequisite for planning effective preventive and therapeutic strategies.METHODS:A cross-sectional survey of ocular symptoms and clinical eye examinations were performed in a sample of 35 rural primary schools in the semi-arid region of Kajiado West sub-county in S.W.Kenya,amongst a seminomadic tribe(Maasai).Students in Grades 1-8 were included.Visual acuity was measured using the Snellen“tumbling E”chart at 6 m.Children with symptoms of refractive error underwent non-cycloplegic refraction.RESULTS:A total of 2036 children(1084 males)between the ages of 4-20y were examined.Conjunctival actinic changes were present in 22%(442/2036).Nine cases were seen with a potential squamous carcinoma.No overt classical ocular signs of vitamin A deficiency were noted,although 181(8.9%)children complained of nyctalopia.Three hundred thirty-six(16.5%)children had a visual acuity worse than 6/12 in either eye,were unable to read N10 near text at 40 cm or had symptoms suggestive of refractive error.Refractive data led to an estimate of hyperopia of+1.00 D or more in 3.9%and of myopia of-0.50 D or more in either eye in 3.0%of the study population.CONCLUSION:Solar exposure-and dust-related conjunctival pathology is common.As this may develop into potentially sight-or even life-threatening conditions,it warrants further study,and preventive strategies may be needed.Complaints of nyctalopia were common and could suggest vitamin A deficiency.The prevalence of refractive errors is low in this rural African population.
摘要AIM:To evaluate the long-term refractive and visual outcomes in infants with retinopathy of prematurity(ROP)treated with intravitreal bevacizumab(IVB),laser photocoagulation(LPC),or combined IVB+LPC therapy,and to assess disease severity on refractive development over five years.METHODS:This retrospective cohort study analyzed data from infants diagnosed with ROP between 2013 and 2018.Patients were categorized into four groups:IVB(n=44),LPC(n=41),IVB+LPC(n=17),and regressed ROP(RROP,n=50).A subgroup analysis was performed for Type 1 ROP and aggressive ROP(AROP).Primary outcomes included spherical equivalent(SE),astigmatism,and visual acuity(logMAR),measured at 6-month intervals up to 60mo.RESULTS:The study included 152 patients(76 females).The mean birth weight was 1256.1±555.6 g,and the mean week of birth was 29.1±2.9wk.RROP infants had the highest SE,closest to emmetropia.The IVB+LPC group showed the most significant myopic shift compared to other groups(P<0.05).In Type 1 ROP,SE was lower in the IVB+LPC group initially,but by 60mo,the difference was not significant.Astigmatism was higher in the LPC group at later time points(36–60mo).However,no differences in visual acuity were observed at the final follow-up among treatment groups.CONCLUSION:Refractive outcomes vary more in Type 1 ROP than AROP.IVB+LPC results in greater myopia;LPC is associated with increased astigmatism.Individualized refractive follow-up is essential,particularly for Type 1 ROP.
摘要AIM:To evaluate the ability of six advanced large language models(LLMs)—in providing accurate,comprehensive,and readable patient education on corneal refractive surgeries[laser in-situ keratomileusis(LASIK),keratorefractive lenticule extraction(KLEx),and photorefractive keratectomy(PRK)]in both English and Chinese.METHODS:This is a cross-sectional,comparative study.Twenty-six questions,compiled from authoritative ophthalmologic sources and covering four domains(procedure basics and eligibility;safety,risks and longterm stability;recovery and postoperative experience;and practical concerns),were administered in both English and Chinese via fresh chat sessions with each LLM,respectively.Five performance metrics were evaluated:accuracy,comprehensiveness,word count,readability,and reproducibility,using appropriate statistical tests.RESULTS:OpenAI o1 and DeepSeek-R1 consistently achieved the highest accuracy and most comprehensive responses,significantly outperforming ChatGPT-4o,Gemini Advanced,Claude Sonnet,and Tongyi Qwen(Friedman P<0.001).Although overall accuracy and comprehensiveness were similar across languages,Chinese responses were significantly longer.Readability varied among the models,with Claude Sonnet generally producing the most readable English texts.Reproducibility analysis revealed moderate consistency,reflecting inherent variability in outputs to identical prompts.CONCLUSION:Reasoning-augmented LLMs,particularly OpenAI o1 and DeepSeek-R1,demonstrate superior performance in delivering bilingual patient education for corneal refractive surgery,with high accuracy and comprehensiveness.However,variations in response length,readability,and reproducibility indicate that further refinement is necessary before these tools can be reliably integrated into clinical practice.
摘要The nonlinear Schrödinger’s equation(NLSE)with Kudryashov’s refractive index which describes the wave dynamics through optical fibers is investigated.The literature review of the previous works are introduced to exhibit the motivation and the importance of this work.In addition,the integration technique of the improved modified extended tanh function scheme is applied on the investigated model to derive various and novel solutions.These solutions are bright,dark and singular solitons.In addition,Weierstrass elliptic,singular periodic,exponential and rational type solutions are derived.It needs to be noted that this governing model can be useful for description of physical processes in nonlinear optics and also the results revealed for the equation are new and originally reported in the present work for the first time.Moreover,the graphical representations of some solutions are depicted to show the powerful and the characteristics of them.
基金supported by the National Natural Science Foundation of China(Grant Nos.12204433,52303331,and 62305307)the“Pioneer”and“Leading Goose”R&D Programs of Zhejiang(Grant No.2024SSYS0013)。
摘要As co-packaged optics(CPO)integrates photonic chips and electronic dies together,accurate and non-destructive post-fabrication characterization of waveguide parameters—width,thickness,and the refractive indices of both core and cladding—becomes critical,because even minute index deviations are amplified in dense interconnects and directly impair the signal integrity and energy efficiency of CPO modules.We take the material refractive index as an example and demonstrate an effective approach for non-destructive parameter extraction of the as-fabricated optical waveguide with a single photonic crystal ring resonator.By lifting the degeneracy of the symmetric and anti-symmetric resonant peak,this single structure suffices to determine the core and clad indices rapidly with high precision.We successfully applied the extracted parameter of the refractive indices to validate the optical transmission of the indexesensitive wavelength division multiplexer device.Our approach has provided a facile solution for postfabrication device parameter evaluation and is readily extendable to geometric parameters.
基金supported by the Wenzhou Science and Te chnology Plan Project,China(No.ZY 2022018).
摘要Refractive surgery can unmask or accelerate transforming growth factor-β-induced(TGFBI)-related corneal dystrophies that are undetectable by routine slit-lamp examination,creating a clear need for a rapid,standardized,preoperative genetic screening.We developed a multiplex,allele-specific real-time quantitative polymerase chain reaction(qPCR)panel targeting five high-frequency TGFBI hotspots(R124C/L/H,R555W/Q)and built a statistics-driven analytical framework to optimize assay decisions.Receiver operating characteristic(ROC)analysis defined locus-specific cycle threshold(CT)cut-offs that were harmonized to a single decision threshold(CT=36)to simplify deployment.Analytical sensitivity was established by Probit modeling of serial two-fold dilutions,and confirmed by≥20 replicates per level.In a 158-sample validation set(38 mutation-positive;120 negative),qPCR agreed perfectly with Sanger sequencing(Cohen’s kappa coefficient(κ)=1.0).Probit analysis yielded locus-specific limit of detection(LoD)values ranging from 0.035 to 0.200 ng/μL;at 0.200 ng/μL,the detection rate was over 95%.Repeatability and intermediate precision were high(CT coefficient of variation(CV)0.34%-1.21%).No cross-reactivity was observed against non-target TGFBI variants or other ophthalmic genes,and interference from blood,oral florainse,or toothpaste produced small,bounded shifts(approximately−7.8%to+2.8%).Calibration with serial dilutions demonstrated linear CT-log(copy)relationships suitable for routine quality control.Prospective screening of 10055 refractive surgery candidates identified six TGFBI carriers(0.06%)harboring R124H(including one homozygote),R124L,R124C,or R555W mutation,all confirmed by Sanger sequencing.This study established a clinically applicable,statistically optimized multiplex qPCR platform that integrated ROC-derived cut-offs and Probit-defined LoD with rigorous evaluations of precision,specificity,and robustness,enabling large-scale population implementation.Positive screening results guide clinical decision-making through a standardized post-screening workflow,and the targeted hotspot screening strategy serves as a cost-effective first-tier high-throughput approach for preoperative risk assessment.The framework provides a transparent,reproducible path to standardize preoperative TGFBI screening and reduce iatrogenic risk in refractive surgery candidates.
基金supported in part by the Natural Science Foundation of Tianjin City(No.20JCZDJC00500)。
摘要In this paper,we propose and numerically characterize the optical characteristics of a high-sensitivity dual-polarization four-channel surface plasmon resonance(SPR)refractive index sensor with wide detection range and high linearity based on photonic crystal fiber(PCF).Four light transmission channels are constructed by using big air holes.The small rectangular air hole in the center of the fiber core is used to add asymmetry.We use gold plasma material to achieve better sensing performance.A thin film of TiO2 is placed on the PCF surface,which assists gold in the adhesion on PCF.The maximum wavelength sensitivity of the sensor can reach 20000 nm/RIU in both x and y polarization modes.While the maximum wavelength resolution of the sensor is 5×10-6 RIU.The average wavelength sensitivity reached 15900 nm/RIU and 15800 nm/RIU in x and y polarization modes.The sensor features R2=0.9969/R2=0.9966 high linear performance in x and y polarization modes and the maximum figure of merit(FOM)values of 509.13 RIU-1/489.63 RIU-1 in x and y polarization modes.Besides,the sensor's detection range is 1.26–1.36,which is a wide refractive index detection range.
基金support by National Natural Science Foundation of China (Nos. 51606158, 12104402)
摘要Fiber-optic sensing technology has the advantages of passivity, anti-electromagnetic interference, longdistancemeasurement, high sensitivity and high accuracy, small size, and adaptability to harsh environments such ashigh-vacuum, high-pressure, and strong magnetic fields compared with the traditional electrical sensing technology.However, with the increasing application requirements, how to further improve the sensitivity of fiber-optic sensors,extend the detection limit and improve the maintenance-free capability has become one of the core issues of thecurrent research. This paper reviews the principle, preparation, and application of fiber-optic microstructured sensingbased on abrupt field type. It specifically outlines the development and applications of micro-nano optical fibers,photonic crystal optical fibers, optical fiber gratings and structured optical fibers, and lists the main preparationmethods of two types of micro-nano optical fibers from the basic theory of optical fiber microstructured sensordevices.
摘要AIM:To compare the clinical outcomes of the current V4c model of the myopic implantable Collamer lens(ICL)with those of laser in situ keratomileusis(LASIK)for the correction of myopia ranging from−2.0 to−18.0 diopters(D).METHODS:This prospective,non-randomized study enrolled participants who underwent either LASIK or implantation of the ICL V4c at Bolor Melmii Eye Hospital.In the LASIK group,participants received Intralase LASIK(I-LASIK)using the Intralase FS-200 femtosecond laser and the MEL-80 excimer laser.Each group comprised the same number of participants and eyes(38 participants,73 eyes).RESULTS:A total of 146 eyes from 76 participants were analyzed.Among the LASIK group,76.3%were female,with a mean age at surgery of 29.76±5.95y(range,20–43y).In the ICL group,92.1%were female,with a mean age of 31.59±8.32y(range,20–49y).Preoperative best-corrected visual acuity(BCVA)did not differ significantly between the LASIK and ICL groups(P=0.68).Postoperatively,the ICL group consistently demonstrated better BCVA(20/20 or better)at all follow-up points,with statistically significant differences observed at 1d(56.2%vs 30.1%,P=0.003)and 3mo(54.8%vs 32.9%,P=0.012).The mean BCVA improvement also favored the ICL group for up to 6mo postoperatively.A higher proportion of eyes in the ICL group achieved uncorrected distance visual acuity(UDVA)of 20/20 or better at 1mo(50.7%vs 41.1%,P=0.319)and 6mo(57.5%vs 43.8%,P=0.136),although these differences were not statistically significant.Predictability was comparable between the groups,except at 6mo,where fewer ICL-treated eyes were within±0.5 D of the intended correction(49.3%vs 64.4%,P=0.094).Nevertheless,both groups achieved identical outcomes within±1.0 D(90.4%,P=1.000).Between 1 and 6mo,78.1%of eyes in the ICL group showed a change in spherical equivalent refraction of no more than 0.5 D,compared to 65.8%in the LASIK group.Refraction stability,defined as a change of less than 1.0 D,remained good in both groups throughout all followup periods.CONCLUSION:Both LASIK and ICL implantation leads to significant improvements in visual outcomes,with early postoperative gains observed in both groups.However,the ICL group demonstrates greater long-term improvement in BCVA compared to the LASIK group,particularly among participants with higher degrees of myopia.Visual outcomes in both groups stabilized by 6mo postoperatively.
摘要Keratorefractive surgery is typically performed to correct refractive errors,resulting in good postoperative outcomes.Certain conditions,such as autoimmune diseases,metabolic diseases like diabetes mellitus(DM),and the use of some drugs,may be absolutely or relatively contraindicated for refractive surgery.DM is a multisystemic disorder affecting various organs and can result in retinopathy,nephropathy,and neuropathy.Persistent hyperglycemia leads to various pathophysiological changes that can alter the biomechanical profile and the wound healing process of the cornea.Proper patient counselling,optimizing blood glucose levels,and frequent follow-up visits to monitor and manage potential complications,such as dry eye,non-healing epithelial defects,and neurotrophic keratitis,are essential for refractive surgeons.Laser-assisted in situ keratomileusis is preferred over photorefractive keratectomy due to its faster healing process.Cataract surgery in people with diabetes warrants various preoperative,intraoperative,and postoperative considerations for the best visual outcomes.This review focuses on the current evidence pertaining to various structural and functional corneal changes occurring in diabetics and their impact on keratorefractive procedures,thus providing a unified,clinically oriented framework to guide refractive surgeons in risk stratification,procedure selection,and postoperative management in patients with DM.