期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到1,722篇文章
< 1 2 … 87 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Functional beverages:recent trends and prospects as potential meal replacers 认领 引用
1
作者 Ravneet Kaur Shubhra Shekhar Kamlesh Prasad 《Food Materials Research》 2024年第1期293-302,共10页
Increased consciousness for health,well-being,and changes in eating habits,such as a shift towards veganism among the masses,has resulted in rapid growth in the functional foods market.Functional beverages are one of ... Increased consciousness for health,well-being,and changes in eating habits,such as a shift towards veganism among the masses,has resulted in rapid growth in the functional foods market.Functional beverages are one of the core areas of research and development among various functional foods.However,ready to drink beverages have some limitations in terms of shelf life,storage,and transportation,so the future trends in the beverage industry could be more towards powdered beverages and ready-to-reconstitute instant mixtures.Due to a sedentary lifestyle,people are trying to follow a balanced diet for weight management,and weight loss programs are also gaining importance.One such category that has come into focus is meal replacements.Nutritionally balanced beverage mixtures have the potential to be used as meal replacements.This review is based mainly on recent and ongoing trends in beverages,such as functional beverages based on dairy sources,fruits and vegetables,cereals-legumes,and millets-based beverages.It also focuses on the future aspects in the beverage industry with a brief about instant beverage powders.Beverages as potential meal replacement products are the major future aspect in this area.This review also discusses the optimization techniques used for the development of beverage mixes. 展开更多
关键词 functional beverages functional foods functional foodshoweverready veganism well being meal replacers powdered beverages health consciousness
暂未订购 下载PDF
Examining short-term and long-term outcomes in octogenarians undergoing isolated surgical aortic valve replacement 认领 引用
2
作者 Marcus Taylor Antony Walker +1 位作者 David Rose Mohamad N Bittar 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第4期228-234,共7页
BACKGROUND As the transcatheter approach to aortic valve disease become more common,the role of surgical aortic valve replacement(SAVR),particularly in older patients,is increasingly contentious.This study aimed to ex... BACKGROUND As the transcatheter approach to aortic valve disease become more common,the role of surgical aortic valve replacement(SAVR),particularly in older patients,is increasingly contentious.This study aimed to examine short-term and long-term outcomes in octogenarians undergoing isolated SAVR.METHODS All consecutive patients aged 80 years and over undergoing isolated first-time SAVR in two cardiac surgery centres between 1997 and 2019 were included.Primary outcomes were in-hospital,1-year and 5-year mortality and overall survival.Secondary outcomes were re-exploration,post-operative renal replacement therapy,post-operative stroke,post-operative permanent pacemaker implantation and post-operative length of stay(PLOS).The multivariate Cox regression analysis was used to identify variables independently associated with overall survival.RESULTS The study comprised 524 patients,which represented 14.9%of all isolated SAVRs performed during the study period(n=524/3516).Mean age was 83.2±2.7 years and 28.1%of patients(n=147)were aged 85 years and above.59.0%of patients(n=309)were female.There were 11.1%of patients(n=58)who underwent minimally invasive surgery and mean logistic EuroSCORE was 12.1%±6.6%.Median PLOS was 9(7-14)days.Overall in-hospital,1-year and 5-year mortality were 4.2%(n=22),9.7%(n=51)and 34.5%(n=181),respectively.For patients who survived to hospital discharge,1-year survival was 94.2%(n=473/502).Median follow-up time was 77(44-101)months and estimated median overall survival was 81(76-86)months.CONCLUSIONS SAVR remains a safe operation in octogenarian patients.Findings from this study suggest that for appropriately selected patients,SAVR can provide durable long-term benefit and should still be considered an appropriate treatment strategy. 展开更多
关键词 octogenarians long term outcomes short term outcomes transcatheter approach cardiac surgery isolated surgical aortic valve replacement transcatheter aortic valve replacement surgical aortic valve replacement savr particularly
暂未订购 下载PDF
Predictors of early cerebrovascular events after transcatheter aortic valve replacement:a systematic review and meta-analysis 认领 引用
3
作者 Yi ZHANG Ying ZHANG +2 位作者 Yi-Jun YAO Tian-Yuan XIONG Mao Chen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第5期309-316,共8页
Background Early cerebrovascular events(CVEs)following transcatheter aortic valve replacement(TAVR)are severe complications,but effective methods for predicting and preventing these events have not been well establish... Background Early cerebrovascular events(CVEs)following transcatheter aortic valve replacement(TAVR)are severe complications,but effective methods for predicting and preventing these events have not been well established.A systematic review and meta-analysis were performed to identify significant predictors of early CVEs post-TAVR.Methods MEDLINE/Embase databases were searched for articles published between December 2015 and April 2023.Original studies evaluating predictors of CVEs within 30 days post-TAVR after adjusting for confounders were included.Two investigators independently extracted data following the PRISMA statement.Meta-analyses of multivariable data were performed using Der Simonian and Laird random-effects models,with results expressed as odds ratios(ORs)and 95%confidence intervals(CIs).Robustness was assessed via Harbord's test,nonparametric trim-and-fill analysis,leave-one-out sensitivity analysis,the QUIPS quality assessment tools,meta-regression,and subgroup analyses.Results Among the 74 included studies,multivariate meta-analyses identified 11 predictors of early CVEs,including 9 patientlevel predictors-a CHA2DS2-VASc≥5,no prior heart failure,diabetes,isolated aortic stenosis,carotid artery stenosis,peripheral artery disease,advanced age,New York Heart Association class≥Ⅲ,and significant left ventricular outflow tract calcificationand 2 procedure-level predictors:the absence of cerebral embolization protection and post-dilation.Additionally,10 patient-level factors and 5 procedure-level factors were not associated with early CVEs,although significant heterogeneity was observed in most analyses.Conclusions This study identified multiple patient-level and procedure-level factors associated or not associated with early CVEs after TAVR.These findings support the development of a comprehensive risk prediction model that can accommodate diverse patient populations and evolving procedural techniques,thereby enhancing clinical risk management strategies. 展开更多
关键词 Meta analysis Transcatheter Aortic Valve Replacement transcatheter aortic valve replacement tavr cerebrovascular events cves following Predictors CHA DS VASc Score systematic review Early Cerebrovascular Events
暂未订购 下载PDF
Application of the best evidence for preventing central venous catheter-related thrombosis in patients undergoing continuous renal replacement therapy 认领 引用
4
作者 Lili Li Jing Wu +4 位作者 Ying Zhang Miaojie Yu Hangyan Ye Yongze Dong Huiping Yao 《International Journal of Nursing Sciences》 CSCD 2026年第2期194-200,I0004,I0005,共7页
Objective:This study aimed to implement evidence-based practice(EBP)for the prevention and management of catheter-related thrombosis(CRT)in patients undergoing continuous renal replacement therapy(CRRT)and to evaluate... Objective:This study aimed to implement evidence-based practice(EBP)for the prevention and management of catheter-related thrombosis(CRT)in patients undergoing continuous renal replacement therapy(CRRT)and to evaluate its clinical effectiveness in enhancing nurses’knowledge and reducing CRT incidence rates.Methods:A systematic approach was employed to retrieve,screen,evaluate,and synthesize literature,identifying best evidence for CRT prevention and management in CRRT patients.From August 1,2023 to February 29,2024,the Ottawa Model of Clinical Application guided the development of audit criteria based on best evidence.Clinical audits were conducted to identify barriers and facilitators to the implementation of evidence,refining the EBP content for CRRT patient CRT prevention and management.Subsequently,from March 1,2024 to September 30,2024,this EBP was implemented in the ICU of a tertiary hospital in Zhejiang Province.A comparative analysis was conducted to assess the implementation rates of audit criteria,nurses’knowledge scores on CRRT patient CRT prevention and management,and patient CRT incidence rates before and after the EBP intervention.Results:A total of 51 nurses and 247 patients were enrolled in this study,with 123 patients assigned to the pre-EBP phase and 124 patients to the post-EBP phase.Compliance rates for all 16 established review indicators demonstrated a significant upward trend following EBP implementation;however,four key indicators failed to meet the 90%compliance threshold:nurse-conducted risk factor assessment,ultrasound-guided venipuncture,X-ray imaging for catheter dysfunction,and administration of thrombolytic therapy.Nurses’knowledge regarding CRT prevention and management was significantly enhanced,with questionnaire scores increasing from(77.72±4.96)to(87.02±6.17)(t=-12.180,P<0.001).Notably,the incidence of CRT decreased substantially from 28.46%to 15.32%,with the difference reaching statistical significance(t=10.257,P<0.001).Conclusion:Evidence-based nursing practice tailored to prevent CRT in patients undergoing CRRT significantly enhances nurses’specialized knowledge in CRT prevention and management,effectively reduces the incidence of CRT,and further fortifies safeguards for patient safety by optimizing clinical nursing quality. 展开更多
关键词 Continuous renal replacement therapy Evidence-based nursing Critical care nursing Central venous catheters Catheter-related thrombosis
暂未订购 下载PDF
An Efficient Certificateless Authentication Scheme with Enhanced Security for NDN-IoT Environments 认领 引用
5
作者 Feihong Xu Jianbo Wu +3 位作者 Qing An Fei Zhu Zhaoyang Han Saru Kumari 《Computers, Materials & Continua》 SCIE EI 2026年第4期1788-1801,共14页
The large-scale deployment of Internet of Things(IoT)technology across various aspects of daily life has significantly propelled the intelligent development of society.Among them,the integration of IoT and named data ... The large-scale deployment of Internet of Things(IoT)technology across various aspects of daily life has significantly propelled the intelligent development of society.Among them,the integration of IoT and named data networks(NDNs)reduces network complexity and provides practical directions for content-oriented network design.However,ensuring data integrity in NDN-IoT applications remains a challenging issue.Very recently,Wang et al.(Entropy,27(5),471(2025))designed a certificateless aggregate signature(CLAS)scheme for NDN-IoT environments.Wang et al.stated that their construction was provably secure under various types of security attacks.Using theoretical analysis methods,in this work,we reveal that their CLAS design fails to meet unforgeability,a core security requirement for CLAS schemes.In particular,we demonstrate that their scheme is vulnerable to amalicious public-key replacement attack,enabling an adversary to produce authentic signatures for arbitrary fraudulent messages.Therefore,Wang et al.’s design cannot achieve its goal.To address the issue,we systematically examine the root causes behind the vulnerability and propose a security-enhanced CLAS construction for NDN-IoT environments.We prove the security ofour improveddesignunder the standard security assumptionandalsoanalyze its practicalperformanceby comparing the computational and communication costs with several related works.The comparison results show the practicality of our design. 展开更多
关键词 IoT certificateless signature public-key replacement attack data integrity aggregation
暂未订购 下载PDF
Olfactory enrichment mitigates delayed neurocognitive recovery after major orthopaedic surgery in older patients:A randomised controlled trial 认领 引用
6
作者 Xinchun Mei Zihan Ni +7 位作者 Shiyu Zhong Jiayi Wang Lin Zhu Zhongyong Shi Yupeng Chen Hailin Zheng Jingxiao Hu Yuan Shen 《General Psychiatry》 CAS CSCD 2026年第2期93-102,共10页
Background Delayed neurocognitive recovery(dNCR)is a prevalent complication in older patients undergoing surgery.It may progress to long-term cognitive impairment and increase the risk of Alzheimer's disease.Aims ... Background Delayed neurocognitive recovery(dNCR)is a prevalent complication in older patients undergoing surgery.It may progress to long-term cognitive impairment and increase the risk of Alzheimer's disease.Aims This study aimed to evaluate the effects of olfactory enrichment on dNCR and to examine the association between olfactory function and dNCR.Methods This sham-controlled,assessor-blind,parallelgroup randomised trial enrolled 149 participants aged65 or older undergoing elective total knee or hip replacement under general anaesthesia.Participants were assigned to either the olfactory enrichment group or the sham group.The intervention group received daily olfactory enrichment from 3 days preoperatively to 7 days postoperatively.Cognitive function was evaluated using a neuropsychological test battery3 days before and 7 days after surgery.Olfactory identification ability was assessed by five-odour olfactory detection arrays.Propensity score matching analysis was employed to mitigate potential confounding and selection bias.Results A total of 131 patients completed the study(62 in the olfactory enrichment group and 69 in the sham group).The overall incidence of dNCR was 26.7%(35 out of 131).In the intention-to-treat analysis,the difference between groups was not statistically significant(19.4%vs.33.3%;χ2=3.259;p=0.071).However,in the 1:1 propensity score-matched cohort(n=82),the incidence of dNCR was significantly lower in the olfactory enrichment group than in the sham group(12.2%vs.39.0%;χ2=7.476;p=0.005).Raw postoperative cognitive scores and individual change scores did not differ between the groups.Participants with decreased olfactory identification scores(n=32)had a significantly higher incidence of dNCR than those with stable or improved scores(40.6%vs.22.2%;χ2=4.183;p=0.041).Conclusions In older patients undergoing major orthopaedic surgery,perioperative olfactory dysfunction is associated with an increased risk of dNCR.Olfactory enrichment may represent a potential nonpharmacological strategy for reducing postoperative cognitive decline in this population. 展开更多
关键词 Older Patients olfactory enrichment delayed neurocognitive recovery dncr alzheimers diseaseaims Major Orthopaedic Surgery olfactory function total knee hip replace Delayed Neurocognitive Recovery
暂未订购 下载PDF
PIF-Identifier:Accurate Low-Overhead Identification of Persistent Infrequent Flows in Network Traffic 认领 引用
7
作者 Bing Xiong Zhuoxiong Li +2 位作者 Yongqing Liu Yu Tang Jinyuan Zhao 《Computers, Materials & Continua》 SCIE EI 2026年第7期629-643,共15页
Persistent Infrequent Flows(PIFs)refer to the packet flows that last for a long time but always at low frequencies in network traffic.Accurate identification of the PIFs plays a vital role in intrusion detection,attac... Persistent Infrequent Flows(PIFs)refer to the packet flows that last for a long time but always at low frequencies in network traffic.Accurate identification of the PIFs plays a vital role in intrusion detection,attack prevention,traffic engineering,and other network fields.However,existing methods often require to save all flows for finding out the PIFs due to their infrequency feature,which brings about the problem of low identification accuracy and high memory overhead.To solve this problem,this paper proposes an accurate PIF identification method with low overhead called PIF-Identifier,composed of a new-flow discriminator and a PIF tracker.Specifically,we first design a compact new-flow discriminator by applying probabilistic data structures,to quickly determine whether a packet flow arrives for the first time within current time window.Then we design a PIF tracker to accurately identify and report persistent infrequent flows.In the PIF tracker,we configure a small-size frequency counter for each tracked flow in accordance with the frequency threshold of the PIF,without sacrificing the accuracy of PIF identification.Furthermore,we design a probabilistic replacement strategy based on the number of time windows of flow persistence,to accommodate newly arrived potential PIFs when there is no vacancy in their mapped buckets of the PIF tracker.Finally,we evaluate the performance of our proposed PIF-Identifier by theoretical analysis and experimental verification with real network traffic traces.Experimental results indicate that the PIF-Identifier achieves the precision of 100%,much higher recall rate and F1 score,as well as lower average relative error than the state-of-the-art methods,significantly promoting the identification performance of persistent infrequent flows. 展开更多
关键词 Network traffic measurement persistent infrequent flows low-overhead PIF identification new-flow discriminator probabilistic replacement strategy
暂未订购 下载PDF
CONSTRUCTION OF ASYMMETRIC ORTHOGONAL ARRAYS WITH REPEATED ROWS 认领 引用
8
作者 Shanqi PANG Ganyu SONG +1 位作者 Jing WANG Yan ZHU 《Acta Mathematica Scientia》 SCIE CSCD 2026年第4期1957-1978,共22页
Orthogonal arrays with repeated rows have significant applications in the domains of statistical experimental design and pure error estimation,quantum information and quantum communication,and scientific computing and... Orthogonal arrays with repeated rows have significant applications in the domains of statistical experimental design and pure error estimation,quantum information and quantum communication,and scientific computing and computer theory,among others.However,there are many unsolved problems on orthogonal arrays with repeated rows.This paper focuses on asymmetric orthogonal arrays.First,we find a bound for asymmetric orthogonal arrays of strength 2 with repeated rows.Second,based on this bound,optimal orthogonal arrays and m-optimal orthogonal arrays are defined.By using the orthogonal decomposition of projection matrices and the contractive replacement method,we construct many asymmetric orthogonal arrays of strength 2 with repeated rows including quite a few optimal and m-optimal ones.Finally,by employing the juxtaposition method and the expansive replacement method,asymmetric orthogonal arrays of general strength with repeated rows are obtained.Some selective new ROAs are tabulated for practical uses. 展开更多
关键词 orthogonal array with repeated rows optimal projection matrices replacement method juxtaposition
暂未订购 下载PDF
Bond of rebar to crumb rubber concrete(CRC)under fiber-reinforced polymer(FRP)-stirrup dual confinement:failure mechanism and behavior modeling 认领 引用
9
作者 Qiang LI Fangduo XIAO +3 位作者 Shiwei LU Jizhong WANG Shikun CHEN Dongming YAN 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第7期730-745,I0043-I0049,共16页
The replacement of traditional aggregates with recycled rubber in concrete is increasingly attractive,driven by sustainability-related considerations.Nevertheless,incorporating rubber particles alters both the microin... The replacement of traditional aggregates with recycled rubber in concrete is increasingly attractive,driven by sustainability-related considerations.Nevertheless,incorporating rubber particles alters both the microinterfacial characteristics and the macroscopic performance of concrete,which leads to the variation in bond behavior between rebar and rubberized concrete.Against this background,42 central pull-out specimens were prepared for bond tests,and the impact of the rubber replacement ratio(ρrv)on the bond behavior was investigated.Moreover,specimens with different confined conditions were designed to identify a reliable strengthening scheme for crumb rubber concrete(CRC)members.The test results show that whenρrv increases from 0%to 30%,the crack width of the splitting specimens decreases,but the bond strength deteriorates simultaneously.Whenρrv increases to 40%,the specimens are subjected to pull-out failure,and the deterioration of the bond strength can be alleviated.Specimens strengthened by fiber-reinforced polymer(FRP)and/or stirrups undergo pull-out failure and exhibit higher bond strength than that of their unstrengthened counterparts.Confinement enhances the bond strength of CRC specimens,beyond which further confinement induces no additional gains.By calibrating rubber-influenced parameters and the confinement critical effect,a mechanics-based model is established for predicting the bond strength of the CRC-rebar interface.Finally,the stochasticity of the bond-slip response is simulated based on the assumption of multi-composite spring-friction units fracturing stochastically,and a continuous bond-slip model with high accuracy and an integral absolute error(EIA)below 10.47%is proposed. 展开更多
关键词 Crumb rubber concrete(CRC) Rubber replacement ratio(ρrv) Bond strength model Fiber-reinforced polymer(FRP)-stirrup confinement Bond-slip model
暂未订购 下载PDF
Compressive Stress-Strain Behavior of Seawater Sea-Sand Recycled Aggregate Concrete under Different Strain Rates and Replacement Ratio of Aggregates 认领 引用
10
作者 ZHANG Kaijian ZHOU Kunjie +1 位作者 LIN Wenqiang ZHANG Qingtian 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第3期658-673,共16页
The stress-strain curves of seawater sea-sand recycled aggregate concrete(SSRAC)with different replacement ratios of recycled coarse aggregate(RCA)or sea-sand under different strain rates were studied.The effects of d... The stress-strain curves of seawater sea-sand recycled aggregate concrete(SSRAC)with different replacement ratios of recycled coarse aggregate(RCA)or sea-sand under different strain rates were studied.The effects of different replacement ratios of RCA or sea-sand,and ages on the characteristic parameters of the stress-strain curve and corresponding dynamic increasing factor(DIF)of SSRAC were analyzed.Scanning electron microscopy(SEM)and nanoindentation tests were used to explain the variation of the characteristic parameters from the microscopic point of view.The results show that,when the replacement ratio of RCA or seasand is 50%,the strain rate sensitivity of elastic modulus is higher than that of peak stress;the DIF of peak stress exhibits a pattern of initially decreasing and then increasing with the increasing replacement ratio of RCA or sea-sand.Conversely,the DIF of elastic modulus initially shows an increase followed by a decrease.The introduction of seawater and sea-sand promotes hydration,resulting in a denser microstructure for SSRAC as compared to that of recycled aggregate concrete,which influences its strain rate sensitivity.Finally,a stressstrain prediction model of SSRAC is proposed,which can provide a theoretical basis for its experimental research and engineering application. 展开更多
关键词 seawater sea-sand recycled aggregate concrete(SSRAC) replacement ratio dynamic increase factor(DIF) strain rate sensitivity stress-strain curve model
暂未订购 下载PDF
Navigating the therapeutic tightrope:Precision use of plasmapheresis and continuous renal replacement therapy in liver failure 认领 引用
11
作者 Manish Manrai Aditya V Pachisia +2 位作者 Saurabh Dawra Siddharth Shukla Atul A Jha 《World Journal of Hepatology》 2026年第5期69-88,共20页
Liver failure,which includes acute liver failure(ALF)and acute-on-chronic liver failure(ACLF),is a life-threatening condition characterised by severe loss of hepatocytes,systemic inflammation,and multi-organ dysfuncti... Liver failure,which includes acute liver failure(ALF)and acute-on-chronic liver failure(ACLF),is a life-threatening condition characterised by severe loss of hepatocytes,systemic inflammation,and multi-organ dysfunction,often leading to mortality rates exceeding 50%.Therapeutic plasma exchange(TPE,also known as plasmapheresis)and continuous renal replacement therapy(CRRT)are essential extracorporeal treatments that detoxify the blood,stabilise patients,and act as a bridge to recovery or transplantation.The debate surrounding the use of TPE and CRRT in liver failure(ALF and ACLF)is ongoing,with a recognised need to clearly define the patient groups,timing,and modality of application.This minireview synthesises evidence from 2016 to 2025,obtained from PubMed,EMBASE,and the Cochrane databases,and examines the mechanisms,indications,protocols,and outcomes of TPE and CRRT in ALF and ACLF.Correct patient selection,timing,and monitoring are essential to optimise benefits while minimising risks such as bleeding,infections,or citrate toxicity.This review examines various aspects of both therapies to help determine the most suitable treatment for liver failure.It highlights the importance of standardised guidelines to improve outcomes across different settings. 展开更多
关键词 Acute liver failure Acute-on-chronic liver failure Therapeutic plasma exchange Continuous renal replacement therapy Extracorporeal therapies Multiorgan failure
暂未订购 下载PDF
Influence of CO2or flue gas(СО2+N2)injection on the change in gas permeability of a subpermafrost hydrate-saturated reservoir:Results of experimental modeling 认领 引用
12
作者 Evgeny Chuvilin Maksim Zhmaev +2 位作者 Sergey Grebenkin Kirill Maerle Yongwon Seo 《Natural Gas Industry B》 2026年第3期425-436,共12页
Large volumes of natural gas stored in hydrate form within marine and subpermafrost environments represent a significant resource for potential extraction and use.Various methods for developing hydrate deposits are cu... Large volumes of natural gas stored in hydrate form within marine and subpermafrost environments represent a significant resource for potential extraction and use.Various methods for developing hydrate deposits are currently under investigation.A promising strategy for efficient methane production involves the injection of carbon dioxide(CO2)or flue gas mixtures(CO2+N2).The introduction of these gases into hydrate-bearing sediments induces methane hydrate dissociation,followed by its partial replacement by CO2hydrate without compromising wellbore integrity.In addition,the CO2-based approach facilitates carbon sequestration within hydrate structures,thereby reducing greenhouse gas emissions.For effective implementation,a detailed understanding of gas permeability behavior in response to CO2or flue gas injection into hydrate-bearing formations is essential.This response was experimentally investigated by injecting CO2and flue gas into sand-clay samples under pressure and temperature conditions representative of subpermafrost gas hydrate reservoirs.The experiments demonstrate that gas permeability decreases markedly during CO2/CH4replacement in the model reservoir,due to the additional formation of CO2hydrate from residual pore water.This reduction may reach several tens of percent,particularly in reservoirs with high residual water content.Consequently,sediments with higher total saturation and lower hydration coefficients exhibit substantially reduced gas permeability following CO2or flue gas injection.Overall,the findings indicate that the extent of permeability reduction during CO2or flue gas injection is strongly governed by the initial reservoir properties and secondary hydrate formation processes.This understanding enables improved prediction and optimization of the CO2/CH4replacement process for the efficient and safe exploitation of gas hydrate resources. 展开更多
关键词 Gas permeability Gas hydrate reservoir CO2-enhanced methane recovery CH4→CO2replacement
暂未订购 下载PDF
Slow continuous ultrafiltration and prolonged intermittent renal replacement therapy: Tailoring renal replacement therapy in intensive care unit 认领 引用
13
作者 Guido Gembillo Matteo Floris +3 位作者 Lorenzo Lo Cicero Giuseppe Spadaro Luca Soraci Domenico Santoro 《World Journal of Nephrology》 2026年第2期122-139,共18页
Acute kidney injury complicates the clinical course of nearly half of all critically ill patients admitted to intensive care,conferring a three-to five-fold elevation in mortality risk.The management of these patients... Acute kidney injury complicates the clinical course of nearly half of all critically ill patients admitted to intensive care,conferring a three-to five-fold elevation in mortality risk.The management of these patients has evolved considerably beyond standardized protocols toward individualized therapeutic strategies.Within this paradigm shift,two modalities warrant particular attention:Slow continuous ultrafiltration(SCUF)and prolonged intermittent renal replacement therapy(PIRRT).SCUF operates through isolated fluid extraction at rates between 100 mL and 500 mL per hour,targeting patients whose preserved kidney function nonetheless fails to manage severe volume overload.The clinical experience with SCUF reveals a complex picture,while certain patient populations,particularly those receiving extracorporeal membrane oxygenation or battling refractory cardiac failure,have shown encouraging results with shortened intensive care stays,equally robust cohorts have experienced concerning progression rates to complete renal replacement therapy and mortality approaching or exceeding 50%.The distinction appears to hinge on meticulous patient selection,with systolic perfusion pressure emerging as a pivotal hemodynamic threshold.PIRRT extends conventional intermittent therapy from the traditional 3-4 hours window to sessions lasting 6-12 hours.Multiple investigations support that this approach achieves comparable mortality and renal recovery outcomes to continuous modalities while reducing costs,facilitating patient mobilization,and decreasing nursing requirements.Current guideline recommendations increasingly favor restrictive,patient-centered approaches over rigid algorithmic initiation.Accumulating evidence supports ultrafiltration rates of 1-1.5 mL/kg/hour,adjusted dynamically according to hemodynamic tolerance and disease trajectory.Yet despite these refinements in our understanding of optimal therapy delivery,fundamental questions persist:Which patients derive maximal benefit from alternative modalities?When should these therapies be initiated or withdrawn,and how can we predict individual treatment response?This review synthesizes current evidence to establish practical decision frameworks for implementing SCUF and PIRRT in critically ill populations,examining clinical indications,safety parameters,fluid removal strategies,and outcome determinants.Our objective is to advance renal replacement therapy from a standardized intervention toward precision nephrology for high-acuity patients. 展开更多
关键词 Heart failure Chronic kidney disease Acute kidney injury Diuretic resistance Renal failure Intensive care unit Slow continuous ultrafiltration Prolonged intermittent renal replacement therapy
暂未订购 下载PDF
Mitochondrial replacement therapy for advanced maternal age and diminished ovarian reserve:Efficacy,challenges,and Vietnamese landscape 认领 引用
14
作者 Luan Nguyen Thanh Dung Le Thi Thuy +1 位作者 Thuy Tran Thi Thinh Ngo Van 《Asian pacific Journal of Reproduction》 CAS 2026年第4期149-159,共11页
Mitochondrial replacement therapy(MRT)has emerged as a disruptive frontier in reproductive medicine to address the challenges of advanced maternal age(AMA)and diminished ovarian reserve(DOR).These conditions are prima... Mitochondrial replacement therapy(MRT)has emerged as a disruptive frontier in reproductive medicine to address the challenges of advanced maternal age(AMA)and diminished ovarian reserve(DOR).These conditions are primarily driven by mitochondrial dysfunction,which leads to adenosine triphosphate(ATP)depletion,oxidative damage,and increased embryonic aneuploidy.Heterologous techniques,such as maternal spindle transfer(MST)and pronuclear transfer(PNT),have demonstrated high clinical efficacy,with studies reporting fertilization rates up to 88.4%and significantly improved blastocyst formation in patients with poor prognoses.While these methods show promise,autologous strategies utilizing stem cell derived mitochondria offer an alternative to maintain full genetic relatedness and avoid the ethical complexities of"three-parent"embryos.However,MRT remains an investigational procedure globally due to critical safety concerns,including mitochondrial"reversion"where maternal mitochondrial DNA(mtDNA)regains dominance and potential mitonuclear incompatibility.In Vietnam,where infertility affects approximately 7.7%of couples,there is a rising demand for such interventions despite significant gaps in national data and specific regulatory frameworks.Establishing a strategic roadmap that includes a national AMA/DOR database and modernized legal guidelines is essential to ensure the safe and ethical integration of MRT into Vietnam’s clinical landscape. 展开更多
关键词 Mitochondrial replacement therapy Mitochondrial dysfunction Mitochondrial donation Advanced maternal age Diminished ovarian reserve
暂未订购 下载PDF
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury 认领 引用 被引量：6
15
作者 Liping Shi Shuyi Liu +2 位作者 Jialing Chen Hong Wang Zhengbo Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期39-56,共18页
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl... Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microglia play an important role in secondary injury and can be activated in response to traumatic brain injury.In this article,we review the origin and classification of microglia as well as the dynamic changes of microglia in traumatic brain injury.We also clarify the microglial polarization pathways and the therapeutic drugs targeting activated microglia.We found that regulating the signaling pathways involved in pro-inflammatory and anti-inflammatory microglia,such as the Toll-like receptor 4uclear factor-kappa B,mitogen-activated protein kinase,Janus kinase/signal transducer and activator of transcription,phosphoinositide 3-kinase/protein kinase B,Notch,and high mobility group box 1 pathways,can alleviate the inflammatory response triggered by microglia in traumatic brain injury,thereby exerting neuroprotective effects.We also reviewed the strategies developed on the basis of these pathways,such as drug and cell replacement therapies.Drugs that modulate inflammatory factors,such as rosuvastatin,have been shown to promote the polarization of antiinflammatory microglia and reduce the inflammatory response caused by traumatic brain injury.Mesenchymal stem cells possess anti-inflammatory properties,and clinical studies have confirmed their significant efficacy and safety in patients with traumatic brain injury.Additionally,advancements in mesenchymal stem cell-delivery methods—such as combinations of novel biomaterials,genetic engineering,and mesenchymal stem cell exosome therapy—have greatly enhanced the efficiency and therapeutic effects of mesenchymal stem cells in animal models.However,numerous challenges in the application of drug and mesenchymal stem cell treatment strategies remain to be addressed.In the future,new technologies,such as single-cell RNA sequencing and transcriptome analysis,can facilitate further experimental studies.Moreover,research involving non-human primates can help translate these treatment strategies to clinical practice. 展开更多
关键词 animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell microglia neuroinflammation non-human primate signaling pathway traumatic brain injury
暂未订购 下载PDF
Clearance eff ects of blood purifi cation on chlorfenapyr and tralopyril in chlorfenapyr poisoning patients 认领 引用 被引量：2
16
作者 Yu Gong Yanling Dong +7 位作者 Yaqing An Hongxin Zhang Yiqing Sun Yijiao Men Hengbo Gao Dongqi Yao Na Meng Yingping Tian 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第1期65-69,共5页
BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute pois... BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute poisoning.METHODS:This retrospective study included 18 patients with acute oral chlorfenapyr poisoning treated at our department between January 2022 and January 2024.All patients received conventional therapies combined with blood purification,including HP,CRRT,and PE.HP was performed three sessions within the fi rst 24 h,followed by CRRT and PE.Serial blood samples were collected to measure plasma concentrations of chlorfenapyr and tralopyril using gas chromatography/liquid chromatography-mass spectrometry(GC/LC-MS).The toxin-clearance eff ects were assessed using a linear mixed-eff ects(LME)model.RESULTS:The hourly decline rate of the plasma chlorfenapyr concentration(median[IQR])was 8.83%(1.79%)for HP,4.12%(1.26%)for CRRT,and 6.85%(1.44%)for PE.LME analysis showed higher decline rate in the plasma concentration with HP(β=5.00;P<0.001)and PE(β=2.15;P=0.003)compared to CRRT.For tralopyril,the hourly decline rates were 3.04%(0.62%)for HP,1.82%(0.48%)for CRRT,and 3.01%(0.37%)for PE.LME analysis showed that the clearance effects of HP(β=0.027;P<0.001)and PE(β=0.022;P=0.001)were superior to CRRT.Pre-treatment toxin levels and the interval from hospital admission to blood purifi cation showed no signifi cant interaction with clearance outcomes.CONCLUSION:In our study,HP was associated with a higher decline rate in plasma chlorfenapyr concentration compared to CRRT and PE,supporting HP as a preferred early intervention.However,all three methods showed limited effi cacy in reducing tralopyril levels.Further research into the toxicokinetics and mechanisms of chlorfenapyr is warranted to optimize purifi cation strategies. 展开更多
关键词 Chlorfenapyr Tralopyril Poisoning Hemoperfusion Plasma exchange Continuous renal replacement therapy
暂未订购 下载PDF
Damage and repair in retinal degenerative diseases:Molecular basis through clinical translation 认领 引用 被引量：3
17
作者 Ziting Zhang Junfeng Ma +3 位作者 Wahid Shah Xin Quan Tao Ding Yuan Gao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1383-1395,共13页
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system,transmitting visual signals to the brain.The injury and loss of retinal ganglion cells are the primary pathological change... Retinal ganglion cells are the bridging neurons between the eye and the central nervous system,transmitting visual signals to the brain.The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative diseases,including glaucoma,ischemic optic neuropathy,diabetic neuropathy,and optic neuritis.In mammals,injured retinal ganglion cells lack regenerative capacity and undergo apoptotic cell death within a few days of injury.Additionally,these cells exhibit limited regenerative ability,ultimately contributing to vision impairment and potentially leading to blindness.Currently,the only effective clinical treatment for glaucoma is to prevent vision loss by lowering intraocular pressure through medications or surgery;however,this approach cannot halt the effect of retinal ganglion cell loss on visual function.This review comprehensively investigates the mechanisms underlying retinal ganglion cell degeneration in retinal degenerative diseases and further explores the current status and potential of cell replacement therapy for regenerating retinal ganglion cells.As our understanding of the complex processes involved in retinal ganglion cell degeneration deepens,we can explore new treatment strategies,such as cell transplantation,which may offer more effective ways to mitigate the effect of retinal degenerative diseases on vision. 展开更多
关键词 cell replacement therapy degeneration glaucoma optic nerve damage regenerative medicine retinal degenerative disease retinal diseases retinal ganglion cells stem cell therapy vision restoration
暂未订购 下载PDF
Learning curve of total ankle replacement from the lateral approach 认领 引用 被引量：1
18
作者 Henryk Liszka Artur Gądek +5 位作者 Anna Maria Zięba Kaja Surowiecka Jakub Kwiatkowski Tomasz Kozioł Michał Sebastian Bochenek Konrad Kwolek 《World Journal of Orthopedics》 2026年第3期52-63,共12页
BACKGROUND According to recent systematic reviews and meta-analyses,the long-term results of total ankle replacement(TAR)are equivalent or superior to ankle arthrodesis with an average 10-year survival approaching 90%... BACKGROUND According to recent systematic reviews and meta-analyses,the long-term results of total ankle replacement(TAR)are equivalent or superior to ankle arthrodesis with an average 10-year survival approaching 90%.Almost all fourth-generation TAR implants are inserted from the anterior approach except for ZimmerTM,which is implanted laterally and with lateral malleolus osteotomy.AIM To evaluate the clinical outcomes and complication rates and to define a multifactorial learning curve of lateral approach TAR.METHODS This single-center retrospective cohort study included 85 ZimmerTMlateralapproach TARs performed by one surgeon from 2019 to 2024.Patient-reported outcome measures were evaluated in 65 patients using the Manchester-Oxford Foot Questionnaire(MOXFQ)and European Foot and Ankle Society(EFAS)scores.Underlying diagnoses,functional outcomes,operative time trends,secondary procedures,and complications rates were analyzed to define a learning curve considering the first 60 consecutive cases.RESULTS The mean follow-up was 30.8 months.Post-traumatic arthritis was the most common underlying diagnosis accounting for 53.5%of cases.Mean EFAS improved by 13.0 points(P0.4),indicating that proficiency is readily achieved due to the short learning curve of this technique.Operative time decreased from approximately 175 min to 125 min after about 25-30 cases.Complication rates declined with experience.In the first 30 cases,there were 19 reoperations in 13 patients(43%)with an additional 5 being managed conservatively compared with 10 reoperations in 7 patients(23%)with 2 conservatively treated complications in the subsequent 30 cases(relative risk=1.86,P>0.05).Infection-related revisions also decreased markedly from 5(16.7%)to 1(3.3%)(relative risk=5.00,P>0.05)between these cohort.Two cases of deep infection occurred in patients with rheumatoid arthritis.One was successfully managed with debridement,and the other required implant removal with cement spacer implantation.CONCLUSION Lateral-approach TAR achieved early patient-reported outcome measure benefits with efficiency and safety improving with experience,requiring 30 cases.This rapid learning curve integrates functional outcomes,operative timing,and complication rates. 展开更多
关键词 Arthroplasty replacement ankle Osteoarthritis Ankle joint Surgical procedures operative methods Surgical approach Lateral approach Learning curve Patient-reported outcome measures
暂未订购 下载PDF
Coronal plane alignment of the knee phenotypes and ankle joint coronal plane alignment patterns in Egyptian population 认领 引用 被引量：1
19
作者 Ahmed A Khalifa Mohamed Moustafa +3 位作者 Shikuria Lemma Mostafa Fayez Ahmed M Abdelaal Amr A Fadle 《World Journal of Orthopedics》 2026年第1期67-80,共14页
BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affectin... BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affecting the alignment,such as ankle joint alignment,should be considered.AIM To determine CPAK distribution in the North African(Egyptian)population with knee osteoarthritis and to assess ankle joint line orientation(AJLO)adaptations across different CPAK types.METHODS A cross-sectional study was conducted on patients with primary knee osteoarthritis and normal ankle joints.Radiographic parameters included the mechanical lateral distal femoral angle,medial proximal tibial angle,and the derived calculations of joint line obliquity(JLO)and arithmetic hip-knee-ankle angle(aHKA).The tibial plafond horizontal angle(TPHA)was used for AJLO assessment,where 0°is neutral(type N),0°is valgus(type B).The nine CPAK types were further divided into 27 subtypes after incorporating the three AJLO types.RESULTS A total of 527 patients(1054 knees)were included for CPAK classification,and 435 patients(870 knees and ankles)for AJLO assessment.The mean age was 57.2±7.8 years,with 79.5%females.Most knees(76.4%)demonstrated varus alignment(mean aHKA was-5.51°±4.84°)and apex distal JLO(55.3%)(mean JLO was 176.43°±4.53°).CPAK types I(44.3%),IV(28.6%),and II(10%)were the most common.Regarding AJLO,70.2%of ankles exhibited varus orientation(mean TPHA was-5.21°±6.45°).The most frequent combined subtypes were CPAK type I-A(33.7%),IV-A(21.5%),and I-N(6.9%).A significant positive correlation was found between the TPHA and aHKA(r=0.40,P<0.001).CONCLUSION In this North African cohort,varus knee alignment with apex distal JLO and varus AJLO predominated.CPAK types I,IV,and II were the most common types,while subtypes I-A,IV-A,and I-N were commonly occurring after incorporating AJLO types;furthermore,the AJLO was significantly correlated to aHKA. 展开更多
关键词 Coronal plane alignment of the knee classification Coronal alignment Ankle joint alignment Knee arthroplasty Knee replacement North African population
暂未订购 下载PDF
Survival outcomes of elderly patients undergoing transcatheter aortic valve implantation after 3 years of follow-up 认领 引用 被引量：1
20
作者 Abdulaziz Algethami Salman Salem Alahmadi +1 位作者 Abdulrahman AlQahtani Mohammed Balghith 《World Journal of Cardiology》 2026年第2期63-71,共9页
BACKGROUND Severe aortic stenosis is typically treated with transcatheter aortic valve implantation(TAVI)in elderly patients with contraindications for surgery or elderly patients who have a high risk for surgical aor... BACKGROUND Severe aortic stenosis is typically treated with transcatheter aortic valve implantation(TAVI)in elderly patients with contraindications for surgery or elderly patients who have a high risk for surgical aortic valve replacement.Currently,there is a paucity of data on the survival outcomes for patients older than 85 years who underwent TAVI.AIM To determine survival and predictors of mortality in patients older than 85 years who underwent TAVI.METHODS A retrospective cohort study was conducted on 64 patients≥85 years of age who underwent TAVI between 2010 and 2023 at the King Abdulaziz Cardiac Center in Riyadh,Saudi Arabia.Baseline demographics,echocardiographic parameters,procedural outcomes,and mortality data were collected and analyzed at the 1-year and 3-year follow-up appointments.RESULTS The mean patient age was 88.3±3.6 years,and 81.3%of the patients were male.The most common comorbidities were hypertension(79.7%),diabetes(60.9%),and coronary artery disease(53.1%).The mean left ventricular ejection fraction was 51.1%with a mean transvalvular gradient of 45.1 mmHg.The 1-year and 3-year survival rates were 82%and 63%,respectively.The mean survival duration was 56.3 months.Multivariate analysis identified body mass index≥30 as significant predictor of early mortality(odds ratio:3.13,95%confidence interval:1.01-4.75).CONCLUSION Favorable survival outcomes were observed in patients 85 years or older who underwent TAVI.The mortality risk increased in patients with obesity. 展开更多
关键词 Aortic valve stenosis Aortic valve replacement Transcatheter aortic valve implantation Geriatric Mortality
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 87 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈