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Methods of preparation,structural characteristics of resistant starch and its relation to human health:a review 认领 引用 被引量：1
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作者 Weiyi Zhang Yang Yang +6 位作者 Chunmin Ma Bing Wang Xiaofei Liu Yan Wang Xin Bian Guang Zhang Na Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1503-1519,共17页
Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromo... Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromoting ingredients that can regulate blood glucose and lipid levels,prevent cancer,and enhance the quality of life.Consequently,new technologies for the preparation of RS are continually being developed to support its industrial production.This review describes the structural and nutritional properties of RS and examines recent advancements in RS preparation methods.Emphasis is placed on how RS structure influences its properties and the physiological mechanisms in vivo.This review aims to stimulate further research into the preparation methods,functional characteristics,and utilization of RS,thereby supporting ongoing developments in the food industry. 展开更多
关键词 Resistant starch Preparation methods Characterization Function Human health
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Physicochemical Properties of Rice Hybrid Progeny from Parents with Divergent Resistant Starch Profiles 认领 引用
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作者 LUO Mingrui JIN Zhicheng +6 位作者 LIU Zhijie ZHOU Wangkai ZHENG Ruifeng HUANG Zehong SHU Xiaoli WU Dianxing AN Zengxu 《Rice science》 SCIE CAS CSCD 2026年第3期297-300,I0183-I0193,共4页
The consumption of foods rich in resistant starch(RS)can help slow down the rise in blood glucose levels,thereby aiding in the alleviation of conditions such as obesity and diabetes.In recent years,RS has gradually be... The consumption of foods rich in resistant starch(RS)can help slow down the rise in blood glucose levels,thereby aiding in the alleviation of conditions such as obesity and diabetes.In recent years,RS has gradually become an important indicator for evaluating the nutritional value of rice. 展开更多
关键词 resistant starch rs can alleviation conditions resistant starch slow down rise blood glucose rice hybrid progeny physicochemical properties obesity blood glucose levels
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Genetic Characterization of Multidrug-resistant Aeromonas Isolates from a General Hospital in China and Identification of a New CphA Variant 认领 引用
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作者 Yanyan Zhou Keyi Yu +8 位作者 Ming Liu Zhenzhou Huang Yanqing Che Mengyu Shi Zhenpeng Li Xiaoli Du Duochun Wang Liyan Ma Li Yu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第7期859-864,共6页
The rise of antibiotic-resistant bacteria has become a serious challenge in healthcare,which is exacerbated by limited development of new antimicrobial agents and the increasing prevalence of multidrug-resistant(MDR)b... The rise of antibiotic-resistant bacteria has become a serious challenge in healthcare,which is exacerbated by limited development of new antimicrobial agents and the increasing prevalence of multidrug-resistant(MDR)bacteria,often leading to treatment failure.Aeromonas spp.,gram-negative bacteria commonly found in aquatic and terrestrial environments,are frequently implicated in both intestinal and extraintestinal infections[1]. 展开更多
关键词 Aeromonas isolates antimicrobial agents antibiotic resistant bacteria new cphA variant genetic characterization multidrug resistant China general hospital
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Fitness and resistance mechanism of Fusarium pseudograminearum mutants resistant to fludioxonil 认领 引用
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作者 TIAN Yingming CHEN Yawei +3 位作者 DUAN Xiaoxin ZHENG Wei XU Jianqiang HOU Ying 《农药学学报》 EI CAS CSCD 北大核心 2026年第2期277-291,244,共15页
Fusarium crown rot(FCR),predominantly caused by Fusarium pseudograminearum,has been listed as a Category Ⅱ disease in six provinces of China,posing a significant threat to wheat production.The phenylpyrrole fungicide... Fusarium crown rot(FCR),predominantly caused by Fusarium pseudograminearum,has been listed as a Category Ⅱ disease in six provinces of China,posing a significant threat to wheat production.The phenylpyrrole fungicide fludioxonil is a key agent for FCR control.Previous studies indicated that resistance to fludioxonil in F.pseudograminearum is primarily associated with altered expression levels of the FpOS1 gene,which encodes a hybrid histidine kinase.However,the roles of mutations in other FpOS genes and the molecular interactions between FpOS proteins and fludioxonil remain elusive.To address these gaps,we generated 16 fludioxonil-resistant mutants with heritable resistance traits by in vitro selection of four sensitive F.pseudograminearum isolates.These mutants exhibited high resistance levels,with resistance factors(RF)ranging from 633.73 to 8617.07.Compared to their parental isolates,the resistant mutants showed significantly reduced mycelial growth rate,sporulation capacity,and pathogenicity.They were also more sensitive to ionic,osmotic,and oxidative stresses and displayed compromised cell wall and membrane integrity.Fludioxonil demonstrated no cross-resistance with tebuconazole or pydiflumetofen;however,it exhibited weak positive crossresistance to pyraclostrobin and moderate positive cross-resistance to iprodione.Fludioxonil treatment significantly promoted glycerol synthesis and inhibited deoxynivalenol(DON)production in parental isolates,whereas these regulatory effects were markedly attenuated in the resistant mutants.Mutation analysis identified mutation sites in FpOS1,FpOS4,and FpOS5 genes,with a lower mutation frequency in FpOS1 and no mutations detected in FpOS2.Molecular docking indicated that amino acid substitutions in FpOS4 and FpOS5 significantly reduced the binding affinity of fludioxonil to these target proteins.In conclusion,F.pseudograminearum poses a moderate risk of resistance to fludioxonil.Point mutations in FpOS4 and FpOS5 genes emerge as key molecular drivers of resistance,likely by diminishing the binding affinity between the fungicide and its proteins.This study clarifies the molecular basis of fludioxonil resistance in F.pseudograminearum and provides a scientific rationale for the judicious use of this fungicide in managing FCR. 展开更多
关键词 Fusarium pseudograminearum fludioxonil resistant mutant survival fitness resistant mechanism
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SBEIIb is responsible for the chalk2 phenotype by regulating the formation of resistant starch in indica rice 认领 引用
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作者 Xinwei Li Zihang Wang +6 位作者 Tianxiao Chen Shen Lin Guiai Jiao Shaoqing Tang Long Chen Xiangjin Wei Peisong Hu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第7期2688-2700,共13页
Rice high in resistant starch is a valuable food for human health,especially for individuals with type 2 diabetes,as it supports effective blood sugar control and provides cardiovascular and intestinal benefits.Howeve... Rice high in resistant starch is a valuable food for human health,especially for individuals with type 2 diabetes,as it supports effective blood sugar control and provides cardiovascular and intestinal benefits.However,developing rice varieties with a high resistant starch content remains a major challenge.In this study,we identified a mutant with increased chalkiness,chalk2,from the mutant library of indica rice Zhongjian 100.The chalk2 mutants exhibited significantly higher amylose and protein contents,while the total starch and lipid contents were reduced.An analysis of resistant starch in chalk2 revealed substantial increases in two resistant starch(RS)types,RS2 and RS3.Electron microscopy revealed abnormal starch granule development in the endosperm.The chalk2 mutant also showed reduced grain length,width,and thickness,as well as a lower seed-setting rate,which ultimately led to a significant reduction in grain yield.Through physical localization,Mut-Map analysis,and transgene complementation,we found that SBEIIb was responsible for the chalk2 phenotypes,and it is a member of the starch branching enzyme(SBE)family specifically expressed in the endosperm.Furthermore,the expression levels,enzymatic activity,and protein abundance of SBEIIb were significantly reduced in chalk2 mutants.These findings suggest that SBEIIb plays a crucial role in regulating the composition of starch and resistant starch formation in indica rice. 展开更多
关键词 Oryza sativa resistant starch amylose rice quality rice yield
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Dual-functional self-assembled nanosystems with enhanced protease resistance:Promoting bacterial aggregation and immune activation for multidrug-resistant bacterial infection 认领 引用
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作者 Nan Gao Yikuan Bian +7 位作者 Shasha Wang Pengfei Bai Chunyang Fang Jiaqi Sun Yihan Li Na Dong Anshan Shan Jiajun Wang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2026年第2期173-193,共21页
Multidrug-resistant bacterial infections are increasing globally and posing a greater threat to human health.The application of direct bactericidal agents can induce secondary infections and treatment failures.The ant... Multidrug-resistant bacterial infections are increasing globally and posing a greater threat to human health.The application of direct bactericidal agents can induce secondary infections and treatment failures.The antibacterial strategy of the innate immune system brings inspiration.Here,we developed highly stable bacterial-aggregating peptides with immunoregulatory function.These peptides were designed to capture multidrug-resistant bacteria,prevent their dissemination,and activate the antibacterial immune response of the host.Among these peptides,the central-bola amphiphile R2F4R2 highly captured bacteria without directly killing them.R2F4R2 was believed to self-assemble through the lateral connection of peptide chains.The tetra-Phe segments formed a hydrophobic core of nanoparticle,with Arg residues appearing on the surface.Notably,R2F4R2 enhanced chemotactic response and phagocytic ability of macrophages,supported a transition to M2-macrophage phenotype to combat bacterial infection.Transcriptome sequencing and molecular docking analyses revealed that R2F4R2 regulated the gene expression associated with immunoregulatory functions and modulated calcium-Rap1 signaling pathways.Finally,R2F4R2 exhibited exceptional stability against proteolytic degradation and effectively entrapped invading pathogenic bacteria Escherichia coli to alleviate skin infections and intestinal inflammation.Overall,the bacterial-aggregating peptides represent a novel and effective strategy to combat multidrug-resistant infections. 展开更多
关键词 Multidrug-resistant bacterial infection Bacterial-aggregating peptide Protease resistance Immune activation
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Managing evolution of metastatic prostate cancer:From hormone-sensitive to castration-resistant disease 认领 引用
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作者 Shengpan Wu Xu Zhang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2026年第3期298-300,共3页
Introduction Prostate cancer(PCa)remains one of the most commonly diagnosed malignancies and a leading cause of cancer-related death among males worldwide.For patients with metastatic disease,treatment strategies are ... Introduction Prostate cancer(PCa)remains one of the most commonly diagnosed malignancies and a leading cause of cancer-related death among males worldwide.For patients with metastatic disease,treatment strategies are largely determined by disease state,including metastatic hormone-sensitive prostate cancer(mHSPC)and metastatic castration-resistant prostate cancer(mCRPC),which represent sequential stages of tumor evolution. 展开更多
关键词 prostate cancer metastatic disease prostate cancer pca remains tumor evolution castration resistant prostate cancer hormone sensitive prostate cancer
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Drug-resistant tuberculosis in children in Indonesia:A population-based analysis of the 2023 Indonesian Health Survey 认领 引用
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作者 Rukmini Rukmini Mahmudah Mahmudah +3 位作者 Hari BasukiNotobroto Ingan Ukur Tarigan Zainul Khaqiqi Nantabah Agung Dwi Laksono 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第7期312-321,共10页
Objective:To analyze the prevalence and risk factors of drug-resistant tuberculosis(DR-TB)among Indonesian children.Methods:This study analyzed data from the 2023 Indonesian Health Survey,which included children aged ... Objective:To analyze the prevalence and risk factors of drug-resistant tuberculosis(DR-TB)among Indonesian children.Methods:This study analyzed data from the 2023 Indonesian Health Survey,which included children aged 0-14 years and household heads nationwide.Binary logistic regression was used to identify factors associated with DR-TB.Results:A total of 423 participants were included in the final analysis.The national prevalence of pediatric DR-TB was 15.9%,with substantial variation across provinces.In the multivariable logistic regression analysis,rural residence(aOR 2.68;95%CI 1.23-5.84),poor TB treatment adherence(aOR 17.353;95%CI 3.098-97.206),and household TB contact(aOR 5.628;95%CI 1.113-28.450)were independently associated with higher odds of DR-TB.Wealth index was significantly associated with DR-TB overall(P=0.018),but no significant differences were observed between individual wealth categories after adjustment.Household TB contact was associated with higher odds of DR-TB(aOR 5.628;95%CI 1.113-28.450).Conclusions:Pediatric DR-TB in Indonesia has a substantial prevalence and marked geographic variation.Rural residence,poor TB treatment adherence,and household TB contact were key factors associated with DR-TB,highlighting the need to strengthen treatment adherence,household contact investigation,and targeted interventions. 展开更多
关键词 Tuberculosis Drug resistant tuberculosis Child Prevalence Socioeconomic factors Indonesia
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Physicochemical Properties of Quinoa RS3 Resistant Starch and Its Effects on Intestinal Flora and Metabolites during in Vitro Fermentation 认领 引用
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作者 WANG Hui MU Xindi +5 位作者 SU Tingting YANG Xiyuan XU Lei YAO Di WANG Changyuan ZHANG Liyuan 《食品工业科技》 EI CAS 北大核心 2026年第12期12-26,共15页
To understand the physicochemical properties of quinoa RS3-type resistant starch(RS3-type QRS)and the effects of its in vitro fermentation on the intestinal flora and short-chain fatty acids(SCFAs),quinoa starch(QS)wa... To understand the physicochemical properties of quinoa RS3-type resistant starch(RS3-type QRS)and the effects of its in vitro fermentation on the intestinal flora and short-chain fatty acids(SCFAs),quinoa starch(QS)was prepared via alkali extraction and then autoclaved to obtain RS3-type QRS,and the amylose content,transmittancy,pasting properties,and thermal properties of both starches were analyzed.The in vitro fermentation characteristics of the two and their effects on intestinal metabolites were further explored using an in vitro fecal simulation fermentation system,16S rRNA sequencing,liquid chromatography-mass spectrometry,and non-targeted metabolomics.Compared with QS,RS3-type QRS had significantly higher contents of resistant starch and amylose(P<0.05),significantly improved transmittancy and solubility(P<0.05),possessed more stable thermodynamic properties,and was better in quality and easier to cook.After adding RS3-type QRS to the in vitro fermentation matrix,the abundance of Faecalibacterium increased whereas that of Escherichia-Shigella decreased.Members of the Firmicutes,including Blautia and Lactococcus,formed the core community in RS3-type QRS and were significantly positively correlated with butyric acid enrichment(P<0.01 or P<0.05).In metabolic pathways of bile secretion,the bile acid levels were significantly increased(P<0.05).SCFAs produced by the intestinal flora,together with the differential metabolites,maintained intestinal homeostasis.The findings from this study provide a reference for exploring the impact of RS3-type QRS on intestinal health and a theoretical basis for its application. 展开更多
关键词 quinoa RS3 resistant starch in vitro fermentation intestinal flora metabolites bile acids
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Recent advances in additive manufacturing of impact-resistant structures with high-performance polymers and their composites 认领 引用
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作者 Long Chanraksmey Wei Zhao +3 位作者 Yafeng Han Yu Chen Oana Ghita Binling Chen 《Additive Manufacturing Frontiers》 CAS CSCD 2026年第1期88-122,共35页
Impact-resistant structures designed to withstand forces and maintain integrity under loads require high compressive strength,energy absorption capacity,tensile strength,and stiffness.These structures typically featur... Impact-resistant structures designed to withstand forces and maintain integrity under loads require high compressive strength,energy absorption capacity,tensile strength,and stiffness.These structures typically feature complex geometries that are difficult to produce using traditional manufacturing methods.Additive manufacturing(AM)technology has revolutionized the fabrication of such structures by offering superior capabilities in complexity,customization,and material efficiency.High-performance polymers(HPPs)including polyamide(PA),polyetherimide(PEI),polyphenylene sulfide(PPS),polyaryletherketones(PAEKs),and polyimide(PI)and their composites have gained prominence for impact-resistant applications due to their exceptional mechanical properties and AM compatibility.This review examines recent advances in the AM of HPPs for achieving impact resistance.It focuses on three key areas:the relationship between process parameters and mechanical/energyabsorbing performance,the properties of HPPs and their composites,and the impact-resistant characteristics of novel structural architectures.Additionally,the study addresses the current challenges and future perspectives in developing 3D-printed impact-resistant structures.By synthesizing this information,the review establishes a foundation for future research in innovative AM designs and new material feedstocks for impact-resistant applications. 展开更多
关键词 Additive manufacturing Impact resistant structures High-performance polymers Composites
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Ultra-high-temperature resistant water-based drilling fluid technology for ten-kilometer ultra-deep wells 认领 引用
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作者 LIU Fengbao YIN Da +3 位作者 LUO Xuwu SUN Jinsheng HUANG Xianbin WANG Ren 《Petroleum Exploration and Development》 SCIE 2026年第1期221-234,共14页
Two types of ultra-high-temperature resistant water-based drilling fluid additives were designed and developed:an ultra-high-temperature resistant salt-tolerant polymer fluid loss reducer,and an ultra-high-temperature... Two types of ultra-high-temperature resistant water-based drilling fluid additives were designed and developed:an ultra-high-temperature resistant salt-tolerant polymer fluid loss reducer,and an ultra-high-temperature resistant micro-nano plugging agent.An ultra-high-temperature resistant water-based drilling fluid system meeting the requirements of ultra-deep well drilling was established.Laboratory test and field application were employed for performance evaluation.The ultra-high-temperature and high-salt resistant polymer fluid loss reducer exhibits a mesh-like membrane structure with numerous cross-linking points,and its high-temperature and high-pressure(HTHP)loss was 28.2 m L after aging at 220℃under saturated salt conditions.The ultra-high-temperature resistant micro-nano plugging agent adaptively filled mud cake pores/fractures through deformation,thus reducing the fluid loss.At elevated temperatures,it transitioned to a viscoelastic state to effectively cement the rock on wellbore wall and enhanced wall stability.The ultra-high-temperature resistant water-based drilling fluid system with a density of 1.6 g/cm3exhibits excellent rheological properties at high temperature and high pressure.Its HTHP fluid loss at 220℃was only 9.6 m L.It maintains a stable performance under high-temperature and high-salt conditions,with a sedimentation factor below 0.52 after holding at high temperature for 7 d,and generates no H2S gas after aging,demonstrating good lubricity and safety.This drilling fluid system has been successfully applied in the 10000-meter ultra-deep well of China,Shenditake 1,in Tarim Oilfield,ensuring the well's successful drilling to a depth of 10910 m. 展开更多
关键词 ultra-high-temperature resistant water-based drilling fluid fluid loss reducer plugging agent ten-kilometer ultra-deep well Shenditake 1 well
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Corrosion-Resistant Printable Copper Enabled by Interface Engineering 认领 引用
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作者 Hongrui Yue Haofei Sun 《Rare Metals》 SCIE EI CAS CSCD 2026年第7期31-33,共3页
Copper remains the most widely used conductive metal in modern electronics because of its exceptional electrical and thermal transport properties[1,2].However,its practical deployment in next-generation flexible,print... Copper remains the most widely used conductive metal in modern electronics because of its exceptional electrical and thermal transport properties[1,2].However,its practical deployment in next-generation flexible,printed,and low-temperature processed devices is fundamentally constrained by one persistent problem:rapid oxidation and corrosion under ambient and harsh chemical environments[3-5].Conventional strategies to mitigate this issue,such as high-temperature sintering under reducing atmospheres[6,7],deposition of inert barrier layers[8],or post-treatment passivation[9,10],inevitably introduce trade-offs between conductivity,process compatibility,mechanical flexibility,and long-term stability.These approaches often require energy-intensive processing,complex equipment,or toxic reagents,and they are poorly suited for scalable printing on polymeric or thermally sensitive substrates.The work by Zhang et al.[11]presents a fundamentally different strategy that shifts copper processing from a purely thermal and physical sintering paradigm to a chemically reactive,molecule-mediated transformation pathway,as shown in Figure 1. 展开更多
关键词 corrosion resistant corrosion conductive metal electrical thermal transport properties howeverits reducing atmospheres deposi oxidation ambient harsh chemical environments conventional printable copper
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Multidrug-resistant Escherichia coli:Updated insights into resistance mechanisms,rapid diagnostics,and emerging control strategies 认领 引用
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作者 Asmaa S.Mansour 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2026年第9期363-375,共13页
Multidrug-resistant(MDR)Escherichia coli(E.coli)is a major global health threat,causing increased morbidity,mortality,and healthcare burden.It is a common cause of community-and hospital-acquired infections,with a str... Multidrug-resistant(MDR)Escherichia coli(E.coli)is a major global health threat,causing increased morbidity,mortality,and healthcare burden.It is a common cause of community-and hospital-acquired infections,with a strong ability to acquire and disseminate resistance genes via horizontal gene transfer and mutations.This review provides an overview of MDR E.coli,focusing on resistance mechanisms,diagnostic approaches,and control strategies.Key resistance mechanisms include production of extended-spectrumβ-lactamases(ESBLs),carbapenemases,efflux pump overexpression,target site alterations,and reduced membrane permeability.Quorum sensing and biofilm formation further enhance bacterial survival and resistance.Diagnostic methods range from conventional antimicrobial susceptibility testing to advanced molecular and genomic techniques such as PCR and whole-genome sequencing.Emerging tools,including Fourier transform infrared spectroscopy,surface-enhanced Raman spectroscopy,MALDI-TOF MS,automated systems,and biosensors,offer rapid and accurate detection.Control strategies involve antimicrobial stewardship programs,alternative therapies such as natural compounds and QS inhibitors,and strict infection prevention measures.Addressing MDR E.coli requires a multidisciplinary approach integrating timely diagnosis,effective treatment,and robust infection control policies.A comprehensive literature search was conducted across major databases,and selected studies were qualitatively analyzed to summarize current knowledge and highlight emerging trends.Understanding these aspects is essential for limiting the spread of MDR E.coli and improving clinical outcomes globally. 展开更多
关键词 Multidrug-resistant Escherichia coli Antimicrobial resistance Resistance mechanisms Diagnostic techniques Control approaches
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Decolonizing the gut from multidrug-resistant bacteria:Current strategies and future perspectives 认领 引用
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作者 Anjali Mishra Deven Juneja 《World Journal of Methodology》 2026年第1期15-23,共9页
The rise of multidrug-resistant organisms(MDROs)represents a serious global health crisis,with the gastrointestinal tract serving as a major reservoir for these pathogens.This review highlights the burden of gut colon... The rise of multidrug-resistant organisms(MDROs)represents a serious global health crisis,with the gastrointestinal tract serving as a major reservoir for these pathogens.This review highlights the burden of gut colonization by MDROs,its role in spreading antimicrobial resistance,and explores current and emerging strategies for decolonization.Various non-antibiotic approaches such as probiotics,prebiotics,bacterial consortia,selective digestive decontamination,faecal microbiota transplantation,bacteriophage therapy,and Clustered Regularly Interspersed Short Palindromic Repeats—CRISPR-associated protein systems along with dietary interventions have been assessed for their potential to restore microbial balance and reduce MDRO carriage.While promising results have emer-ged from early studies and animal models,most interventions remain investigational.Rigorous clinical trials,standardized protocols,and safety assessments are essential before these approaches can be integrated into routine practice for MDRO management. 展开更多
关键词 Antimicrobial resistance Fecal microbiota transplantation Gut decolonisation Multidrug-resistant organisms Selective digestive decontamination
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Bioelectrochemical mitigation of soil antibiotic resistance:Disruption of bacteriophage transmission and resistant hosts 认领 引用
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作者 Feihong Zhai Beiyi Li +6 位作者 Xiaodong Zhao Pengyu Zhao Side Yang Xiaojing Li Teng Wang Geng Liu Pingmei Yan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期283-294,共12页
The proliferation of antibiotic resistance genes(ARGs)in environment poses a threat to global public health.Although microbial fuel cell(MFC)has been demonstrated to mitigate ARG amplification,the mechanism remains un... The proliferation of antibiotic resistance genes(ARGs)in environment poses a threat to global public health.Although microbial fuel cell(MFC)has been demonstrated to mitigate ARG amplification,the mechanism remains unclear.This study employed metagenomic sequencing combined with the DeepARG-LS model for profiling ARGs and further analyzed the effects of MFCs on them in tetracycline-contaminated soil.Consequently,tetracycline addition(AT treatment)elevated total ARG abundance by 31%,whereas MFC application(MT treatment)reduced it by 12%.The deep learning model revealed a 38%reduction in the richness of ARG subtypes in the MT compared to the AT.Proteobacteria dominated as ARG hosts,accounting for 78%of ARGs in the AT,but declined by 18%in the MT.Notably,the archaeal Nitrososphaeraceae was identified as a host for tetA(48).Species-level analysis identified 12 ARG-carrying bacterial taxa,the abundance of most of which was suppressed(abundance)by MFCs.The richness of ARGs host bacteria was 38%lower in the MT treatment than that in the AT treatment.Meanwhile,the abundance of the indole biosynthesis gene(tryptophanase,EC 4.1.99.1)exhibited a consistent trend with the richness of ARGs hosts.Mechanistically,the suppression of ARG-host bacteria may be attributed to enhanced indole biosynthesis(as indicated by increased tryptophanase abundance),coupled with reduced abundances of mobile genetic elements(84%)and virulence factors(11%),and a decline in phagemediated ARG transmission(19%).Overall,these findings provide insights into bioelectrochemical controlling ARG dissemination in soils. 展开更多
关键词 Bioelectrochemical remediation Metagenomics Antibiotic resistance genes Bacteriophage Deep learning
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Application of an efficient adenine base editing system in developing Danshen(Salvia miltiorrhiza)dinitroaniline-resistant germplasm 认领 引用
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作者 Huanan Han Ziwen Wu +4 位作者 Zaijie Zhang Yusen Qu Yingcan Wang Pingping Wang Changle Ma 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第5期1234-1244,共11页
Chinese herbal medicine Danshen(Salvia miltiorrhiza)has suggested therapeutic effects on cardiovascular and cerebrovascular diseases,inflammatory reactions and tumors,perhaps due to secondary metabolites,such as tansh... Chinese herbal medicine Danshen(Salvia miltiorrhiza)has suggested therapeutic effects on cardiovascular and cerebrovascular diseases,inflammatory reactions and tumors,perhaps due to secondary metabolites,such as tanshinone.Danshen is sensitive to most broad-spectrum herbicides,thus it is a challenge to manage weeds during planting.Although CRISPR/Cas gene editing has been used to knock out important genes in Danshen,the more accurate base editing method has rarely been applied to this species.We developed an efficient adenine base editing system for Danshen and observed its editing effect in callus and transgenic plants.To demonstrate the efficacy of this technique,we generated several novel Danshen germplasms with mutant a-tubulins,some of which displayed resistance to a dinitroaniline herbicide,pendimethalin,in Danshen planting.We also found distinct effects of the different Danshen mutant tubulin homologues on dinitroaniline sensitivity,perhaps indicating a functional differentiation of the a-tubulin genes.Our work provides a new gene modification method for Danshen breeding,which might be extended to other medicinal plants. 展开更多
关键词 Medicinal plant Adenine base editor a-Tubulin Pendimethalin Herbicide resistance
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Banana defense response against pathogens:breeding diseaseresistant cultivars 认领 引用
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作者 Hongyun Zeng Yuanli Wu +2 位作者 Linbing Xu Junhui Dong Bingzhi Huang 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第1期62-72,共11页
Banana(Musa spp.),being a globally significant fruit crop,faces a myriad of threats from various diseases,such as Fusarium wilt,Xanthomonas wilt,bunchy top disease,and weevils disease.This review provides an overview ... Banana(Musa spp.),being a globally significant fruit crop,faces a myriad of threats from various diseases,such as Fusarium wilt,Xanthomonas wilt,bunchy top disease,and weevils disease.This review provides an overview of recent advancements in molecular mechanisms and immune signaling pathways underlying disease resistance in banana.First,the review discusses the latest research advances on banana pests and diseases.Subsequently,this review explores the immune responses and signaling pathways,pattern recognition receptor-triggered immunity,effector-triggered immunity,cell death,reactive oxygen species,autophagy,hormonal pathways,and other players involved in bananaedisease interactions.Finally,the review discusses the current understanding of the genetic architecture of disease resistance in banana,focusing on the identification of defense-related genes and quantitative trait loci associated with resistance to major pathogens and offering recommendations for genetic research.The conclusion underscores the significance of research on banana immunity,specifically highlighting the crucial need to identify endogenous resistance genes and elucidate immune signaling pathways for future efforts aimed at breeding disease-resistant banana.This review offers a comprehensive perspective on the molecular mechanisms underlying disease resistance in banana and serves as a valuable reference for breeding efforts aimed at enhancing banana's resistance to pathogens. 展开更多
关键词 Banana Disease resistance Molecular mechanism Immune signaling pathway
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Modulation of Scion Immunity by Resistant Rootstocks in the Pepper–Ralstonia solanacearum Pathosystem 认领 引用
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作者 Bizhen Lin Wenzhong Lin +2 位作者 Dongmei Lian Susu Yuan Weiying Wang 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第5期272-284,共13页
Grafting is a common strategy to control bacterial wilt(Ralstonia solanacearum)in susceptible crops,including pepper.However,the contribution of resistant rootstocks to scion immunity,beyond physical pathogen exclusio... Grafting is a common strategy to control bacterial wilt(Ralstonia solanacearum)in susceptible crops,including pepper.However,the contribution of resistant rootstocks to scion immunity,beyond physical pathogen exclusion,requires further elucidation.In this study,susceptible‘HF8’scionswere grafted onto six rootstock genotypes,and their resistance was evaluated via leaf-clip inoculation,which bypasses root-mediated physical barriers.Scions grafted onto resistant rootstocks exhibited restricted pathogen spread and higher survival rates;specifically,the NK4-HF8 combination demonstrated a 100%survival rate,compared to 11%in susceptible-rootstock combinations and 46%in self-grafted controls.Comparative transcriptomic profiling revealed distinct transcriptional reprogramming in scions on the resistant NK4 compared to the susceptible JD2 following infection.These changes involved the modulation of genes associated with pathogen perception(NDR1-like,Xa21),defense-associated transcription factors(CaNAC90,CaMYB13),and specific antioxidant isoforms(CaAPX3,CaAPX6).Physiological analyses indicated that resistant rootstocks are associated with localized hydrogen peroxide accumulation in the scion,alongside the coordinated activation of an antioxidant gene network including CaSOD,CaCAT,CaPOD,CaAPX,and CaGST.These findings suggest that resistant rootstocks modulate scion immunity by regulating transcriptional networks linked to oxidative defense and redox homeostasis,offering potential physiological markers for rootstock selection in pepper. 展开更多
关键词 Capsicum annuum Ralstonia solanacearum grafting scion resistance antioxidant defense
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Engineering isolated Al2O3 island enables adjacent TiO2-supported Ir@Pt nanoparticles for efficient and sulfur-resistant lean methane oxidation 认领 引用
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作者 Jinwei Wu Junfei Chen +1 位作者 Mingkang Zhang Zebao Rui 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第4期400-410,共11页
Sulfur-induced catalyst deactivation has been a challenge in the design of gaseous pollutants purified catalyst.As the mainstream strategy for anti-sulfur catalyst design,the incorporation of sacrificial components in... Sulfur-induced catalyst deactivation has been a challenge in the design of gaseous pollutants purified catalyst.As the mainstream strategy for anti-sulfur catalyst design,the incorporation of sacrificial components into the catalyst bulk still faces issues such as increased cost and rapid activity decline.Herein,the physical isolated island strategy is proposed to improve the sulfur resistance and cost-effectiveness of a lean methane oxidation catalyst at no cost of its high activity.The isolated Al2O3 island suppresses the formation of sulfates on adjacent Ir@Pt nanoparticles and avoids the sulfation of Ir@Pt/TiO2.Meanwhile,the isolated Al2O3 island draws little effect on the chemical states of active sites.The sulfur adsorption function of isolated Al2O3 island and high activity of Ir@Pt/TiO2 are synergistically combined,leading to both remarkably high CH4 oxidation activity(TOF=1.2 s-1 at 350℃)and high sulfur resistance without observable activity loss during 50 h on-stream test under 50 ppm SO2 and a space velocity of 30000 mL g-1 h-1.Such isolated-island strategy provides a meaningful reference for the efficient sulfur resistance catalyst design. 展开更多
关键词 Sulfur resistance Catalytic methane oxidation Isolated island Support-metal interaction Alumina
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Research Progress on Metal‐Organic Framework Materials in Corrosion‐Resistant and Antimicrobial Metal Functional Coatings 认领 引用
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作者 Yanchun Zhao Yunbo Lan +5 位作者 Qi Chang Fei Zhou Yongsheng Lin Peter KLiaw Peiqing La Faqi Zhan 《Rare Metals》 SCIE EI CAS CSCD 2026年第6期212-245,共34页
Metal‐organic frameworks(MOFs)hold significant potential across numerous advanced disciplines due to their exceptional properties,including high specific surface area,tunable porosity,structural diversity,and customi... Metal‐organic frameworks(MOFs)hold significant potential across numerous advanced disciplines due to their exceptional properties,including high specific surface area,tunable porosity,structural diversity,and customizable functionality.Increasing attention has been directed toward employing MOFs in coatings that offer both antimicrobial activity and corrosion resistance.This review systematically summarizes the novel applications of MOFs in protective coatings for metal surfaces,with an in‐depth discussion of preparation techniques,microscopic structural regulation,protective performance,and mechanisms underlying corrosion resistance and antimicrobial action.Studies demonstrate that MOF‐based protective coatings fabricated through various methods can substantially enhance the corrosion resistance of metal substrates.Regarding antimicrobial activity,the synergistic and complementary effects of two primary mechanisms are emphasized:sustained release of metal ions achieves long‐term antibacterial activity,whereas photodynamic/photothermal effects enable rapid sterilization and biofilm disruption.Despite significant advances in dual‐protection applications using MOFs,critical technical challenges persist,including complex fabrication processes,cost management difficulties,limited biocompatibility,and insufficient long‐term stability.Future research should focus on optimizing fabrication protocols,reducing costs,improving biocompatibility,and enhancing long‐term stability to enable the widespread industrial application of these intelligent protective materials in high‐end equipment manufacturing and biomedical engineering. 展开更多
关键词 antimicrobial and corrosion resistance mechanisms fabrication processes metal‐organic frameworks(MOFs) protective coatings structural regulation
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