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An innovative treatment for hypoxic-ischemic encephalopathy:Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement 认领 引用 被引量：1
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作者 Chao Han Shuna Chen +3 位作者 Zihan Shi Xin Guan Wei Zou Jing Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3017-3025,共9页
Stem cell therapy shows promise for treating brain injuries;neural stem cells in particular are capable of repairing damage by forming new nerve cells and supporting recovery.However,optimizing the implantation and fu... Stem cell therapy shows promise for treating brain injuries;neural stem cells in particular are capable of repairing damage by forming new nerve cells and supporting recovery.However,optimizing the implantation and functionality of these cells in damaged brain regions remains challenging.Silk fibroin,a natural protein derived from silkworm silk,is a biocompatible material with exceptional properties that are useful for tissue engineering.Its biodegradability,mechanical robustness,and ability to promote cell growth make it particularly valuable for biomedical applications.Silk fibroin nanomaterials,which comprise silk fibroin processed into nanostructures,offer enhanced surface area,improved loading capacity for bioactive molecules,and superior nanoscale interactions with cells compared with bulk silk fibroin materials.In this study,we first extracted human-derived neural stem cells from a 14-week-old human fetus.Then,neural stem cells were loaded with 1%silk fibroin nanomaterials,which was identified as the optimal concentration to support human-derived neural stem cell growth and release of neurotrophic factors.Finally,1%silk fibroin nanomaterials were implanted into a rat model of hypoxic-ischemic brain injury.The results showed that,compared with the treatment with human-derived neural stem cells alone,silk fibroin hydrogel carrying human-derived neural stem cells was significantly more effective at alleviating brain tissue damage,increasing neurotrophic factor secretion in the brain microenvironment,and promoting motor and cognitive function recovery.These findings suggest that silk fibroin nanomaterials loaded with human-derived neural stem cells could be used to treat hypoxic-ischemic encephalopathy.However,the mechanisms and related signaling pathways by which hydrogels combined with cells exert their reparative effects still require further in-depth investigation. 展开更多
关键词 astrocyte deactivation axonal development cognitive recovery hypoxic-ischemic brain injury motor function nerve regeneration neural stem cells neurotrophic factor silk fibroin hydrogel synapse formation
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Silk components and properties of the multilayer cocoon of the greater wax moth,Galleria mellonella 认领 引用
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作者 Kaiyu Guo Jingmin Duan +5 位作者 Xinyuan Jing Xiaolu Zhang Qiao Ding Zhaoming Dong Qingyou Xia Ping Zhao 《Insect Science》 SCIE CAS CSCD 2026年第4期1447-1464,共18页
The greater wax moth Galleria mellonella is a major pest of brood combs,and produces large quantities of strong,elastic silk in the environment.However,little research has been conducted on the silk glands(SGs),silk c... The greater wax moth Galleria mellonella is a major pest of brood combs,and produces large quantities of strong,elastic silk in the environment.However,little research has been conducted on the silk glands(SGs),silk composition and functions of G.mellonella.In this study,we compared the morphologies of the SGs of G.mellonella and Bombyx mori and found that the nuclei of the anterior SGs differ distinctly.We also investigated the protein components and morphology of the G.mellonella cocoon in terms of its multilayer structure.Proteomic analyses identified 158 secretory proteins across the various cocoon layers.Fibroin,sericin,seroin and adhesive proteins were the most abundant proteins.The expression patterns of the major silk genes were investigated,and the results revealed the specific expression of P16 and Seroin3 genes in the anterior SG.Scanning electron microscopy and proteomic analyses of the cocoon layers showed that the sericin contents in the outermost and middle layers were significantly higher than that in the innermost layer.We extracted the soluble proteins from the different cocoon layers and evaluated their antimicrobial activities in vitro.Only the outermost cocoon layer showed antibacterial activity against Escherichia coli.Mechanical property tests showed that G.mellonella silk was stronger than B.mori silk.Our study provides important information on the composition and properties of G.mellonella cocoon silk,and serves as a basis for future research and use. 展开更多
关键词 antibacterial activity Galleria mellonella cocoon mechanical properties proteomics silk protein
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Spider silk applications:Dermatologic theranostics,cosmetics,aerospace,textile and electronics 认领 引用
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作者 Leonard Whye Kit Lim 《Journal of Dermatologic Science and Cosmetic Technology》 2026年第1期53-58,共6页
Spider silk is an exceptional biomaterial renowned for its strength,elasticity,biodegradability,and biocompatibility.Advances in recombinant DNA have enabled scalable production,broadening its applications.In biomedic... Spider silk is an exceptional biomaterial renowned for its strength,elasticity,biodegradability,and biocompatibility.Advances in recombinant DNA have enabled scalable production,broadening its applications.In biomedicine,it supports wound healing,nerve regeneration,sutures,and drug delivery due to its low immunogenicity.In cosmetics,its amino acid-rich profile enhances skin hydration and repair.In aerospace and electronics,its strength,thermal stability,and optical clarity enable use in lightweight composites and biodegradable sensors.However,challenges such as cost-effective production,scalability,and regulatory approval remain barriers to widespread adoption.Future progress will rely on integrating artificial intelligence,synthetic biology,and sustainable technologies to optimize manufacturing and unlock new applications.This review highlights spider silk’s growing potential across industries and underscores the importance of overcoming current limitations to position it as a key eco-smart material for the future. 展开更多
关键词 Spider silk Dermatologic theranostics Cosmetics Aerospace Textile Electronics
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Three leading silk enterprises in Shengze awarded Geographical Indication Certification 认领 引用
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作者 Zhong Mengxia 《China Textile》 2026年第1期8-9,共2页
Recently,the China National Intellectual Property Administration released the"List of Enterprises Approved to Use the Geographical Indication Logo."The"Wujiang Silk"geographical indication logo has... Recently,the China National Intellectual Property Administration released the"List of Enterprises Approved to Use the Geographical Indication Logo."The"Wujiang Silk"geographical indication logo has been renewed and launched.This official approval serves to distinguish and celebrate the quality and cultural heritage of Shengze silk,and the use of this symbol is a testament to that distinction.Three enterprises from Shengze have been approved to use the logo:Saint Joy,Huajia Silk,and Xinmin Silk. 展开更多
关键词 silk geographical indication Shengze cultural heritage certification xinmin silk quality Wujiang
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Green Fabrication of High-strength Silk Fibroin Hydrogels via Thermal Oscillation in All-aqueous Media 认领 引用
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作者 Yu-Si Long Mei-Yi Lu +7 位作者 Jia-Wei Qi Geng Chen Yu Sun Xiu-Xia He Tian-Hui Zhang Li-Guo Cui Jun-Li Hu Yi-Chun Liu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第8期2549-2560,I0011,共12页
Silk fibroin hydrogels frequently exhibit insufficient mechanical strength for biomedical applications.Conventional enhancement strategies often rely on toxic crosslinkers or nondegradable components,thereby compromis... Silk fibroin hydrogels frequently exhibit insufficient mechanical strength for biomedical applications.Conventional enhancement strategies often rely on toxic crosslinkers or nondegradable components,thereby compromising biocompatibility and biodegradability.Recently emerged organic solvent-based methods represent an advance,but their associated environmental toxicity remains a concern.In this work,we present a novel thermal oscillation strategy for fabricating high-strength silk fibroin hydrogels exclusively from all-aqueous silk fibroin solutions,eliminating the need for toxic chemicals or non-degradable materials.The resulting hydrogels exhibit outstanding mechanical properties,tensile strength of 2.6 MPa,elongation rate of 152.6%,and toughness of 3.0 MJ/m3,which not only surpass the organic solvent-derived silk fibroin hydrogels but also rival the dual-crosslinked,double-networked or composite systems.The silk fibroin hydrogels also exhibit a minimal swelling ratio,outstanding long-term integrity,and excellent biocompatibility.The robust,biocompatible,and biodegradable silk fibroin hydrogels are promising for biomedical applications such as load-bearing tissue scaffolds,long-term implantable drug delivery systems,and durable wound dressings. 展开更多
关键词 Silk fibroin Hydrogel Strength
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Impacts of Soil Moisture–Atmosphere Coupling on the Silk Road Pattern in Summer 认领 引用
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作者 Jing WANG Siguang ZHU +1 位作者 Haishan CHEN Fei FENG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2026年第6期1182-1197,共16页
Based on CMIP6 model simulations,this study investigates the impacts and mechanisms of soil moisture–atmosphere coupling(SA)on the Silk Road Pattern(SRP)in the Northern Hemisphere summer.A comparison between LS3MIP(u... Based on CMIP6 model simulations,this study investigates the impacts and mechanisms of soil moisture–atmosphere coupling(SA)on the Silk Road Pattern(SRP)in the Northern Hemisphere summer.A comparison between LS3MIP(uncoupled)and AMIP(coupled)experiments reveals that weakened SA alters both the position and intensity of the SRP wave train centers,showing a positive–negative–positive–negative anomalous distribution around 40°N(in meridional wind pattern).The results indicate that the SA in the Tibetan Plateau(TP)region plays an important role in the distribution of the SRP.Furthermore,SA significantly influences the SRP wave train characteristics in midlatitude regions by regulating surface heat fluxes and atmospheric heat sources(),with notable geopotential height anomalies over the Caspian Sea,the TP and Northeast Asia.Specifically,due to the weakening of the SA,the cooling effect over the TP induces subsidence,while the regions surrounding the Caspian Sea and Northeast Asia exhibit heat source anomalies accompanied by ascending motion.This results in a corresponding positive–negative–positive geopotential height anomaly pattern associated with the SRP,ultimately influencing the wave train distribution of the SRP.Thus,SA is an important factor driving the variability of the SRP wave train. 展开更多
关键词 soil moisture-atmosphere coupling Silk Road Pattern LS3MIP atmospheric heat sources
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Emeralds from the Silk Roads:From Myth to Reality 认领 引用
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作者 Marie-Laure Cassius-Duranton Vincent Pardieu Stefanos Karampelas 《宝石和宝石学杂志（中英文）》 CAS 2026年第1期39-54,共16页
Although the emerald deposits in India and the Himalayas were not officially discovered before the 20th century,recent gemological analyses conducted by the LFG(French Gemological Laboratory)on emeralds from historica... Although the emerald deposits in India and the Himalayas were not officially discovered before the 20th century,recent gemological analyses conducted by the LFG(French Gemological Laboratory)on emeralds from historical jewelry dating back to the 16th century have shown that they correspond to the characteristics of the Swat deposits(Pakistan).This discovery is consistent with ancient gemological literature,which,since Theophrastus(4th century BCE),mentions the Himalayas as a source of emeralds.This interdisciplinary article explores the methodological difficulties inherent in historical gemology and highlights the importance of scientific gemology for art history and archaeology. 展开更多
关键词 emerald Silk Road history of gemstones Swat Davdar Colombia Pliny Theophrastus
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Silk Fibroin Composite Hydrogel:Modulating Immune Microenvironment to Enhance Diabetic Wound Healing 认领 引用
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作者 HE Wanjun HE Chuanglong 《Journal of Donghua University(English Edition)》 CAS 2026年第3期3-14,共12页
To remodel the inflammatory microenvironment and accelerate chronic wound(such as diabetic wound)healing,this study proposes a novel multi-target immunomodulatory strategy based on an advanced silk fibroin composite h... To remodel the inflammatory microenvironment and accelerate chronic wound(such as diabetic wound)healing,this study proposes a novel multi-target immunomodulatory strategy based on an advanced silk fibroin composite hydrogel dressing that synchronously regulates macrophage polarization and regulatory T cell(Treg)proliferation.The rationally designed composite hydrogel is constructed from a three-component hydrogel(named GCS)consisting of gelatin methacryloyl(GelMA),quaternized chitosan(QCS),and thiolated silk fibroin(SFTK).By further loading metformin(Met)and interleukin-2-incorporated poly(lactic-co-glycolic acid)microparticles(IL-2@PLGA),the final composite hydrogel denoted as Met/IL-2@PLGA/GCS was fabricated,which enabled sequential and controllable drug release.Scanning electron microscopy showed a well-defined three-dimensional microporous structure;rheological analysis and compressive stress-strain tests demonstrated favorable mechanical properties;in vitro drug release studies confirmed sequential release kinetics of the therapeutic agents.Live/dead cell staining confirmed that the composite hydrogel possessed excellent cytocompatibility.Immunofluorescence and flow cytometry results showed that the composite hydrogel significantly promoted M1-to-M2 macrophage polarization and enhanced Treg proliferation.In vitro angiogenesis assays with human umbilical vein endothelial cells(HUVECs)revealed an enhancement in tube formation capacity.In vivo experiments substantiated the hydrogel dressing’s superior wound healing performance.Collectively,these findings provide compelling evidence that the multifunctional Met/IL-2@PLGA/GCS composite hydrogel achieves synergistic therapy for diabetic wound healing through modulation of inflammation,promotion of angiogenesis,and acceleration of tissue regeneration. 展开更多
关键词 multifunctional hydrogel modified silk fibroin immune cell diabetic wound healing synergistic immunomodulation
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The Artistic Characteristics and Historical Responsibility of“Silk Road Poetry”During the War of Resistance 认领 引用
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作者 SHENG Xuelian ZHOU Xiaoyu WANG Jing 《Cultural and Religious Studies》 2026年第3期184-191,共8页
During the War of Resistance,Northwest poetry,influenced by the May Fourth New Literature tradition,exhibited a distinct spirit of“enlightenment”and“struggle”.Poets inherited the realist tradition,using poetry as ... During the War of Resistance,Northwest poetry,influenced by the May Fourth New Literature tradition,exhibited a distinct spirit of“enlightenment”and“struggle”.Poets inherited the realist tradition,using poetry as a weapon to expose the atrocities of the enemy and puppet forces,awaken public consciousness,and call for national salvation.At the same time,they made significant progress in the direction of“nationalization and popularization”,creating poems that were sincerely emotional and uplifting in style,reflecting both the lives and struggles of borderland people and the belief in the inevitable victory of the war of resistance and the revolutionary ideals of the proletariat.Northwest poetry,in its specific historical context,fulfilled the practical functions of serving the war through literature and educating the people,provided valuable experience for the popularization of new poetry,and established the unique poetic charm of Northwest poetry,demonstrating its sense of responsibility to the era. 展开更多
关键词 Silk Road poetry era popularization enlightenment
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What Can China Bring to New Zealand in an Uncertain World?——An article published in NZ Herald's The Silk Road Edit 认领 引用
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作者 Wang Xiaolong 《Beijing Review》 2026年第34期I0006-I0008,共3页
Every day,the news seems to deliver a familiar set of concerns:wars and conflicts,trade disputes.slowing economic growth,rising living costs,and an increasingly complex international environment.Uncertainty has become... Every day,the news seems to deliver a familiar set of concerns:wars and conflicts,trade disputes.slowing economic growth,rising living costs,and an increasingly complex international environment.Uncertainty has become one of the defining features of our time.The more unpredictable the world becomes,the more people search for something they can rely on.Where will future economic growth come from?What can restore confidence in the years ahead?For New Zealand,China has increasingly become part of the answer. 展开更多
关键词 new zealand economic growth China confidence international environment uncertainty silk road wars conflicts
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Silk’s New Frontier--How China is weaving tradition and innovation into an industry renaissance 认领 引用
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作者 ZHANG YAGE 《ChinAfrica》 2026年第1期48-50,共3页
“The silk of Suzhou,Hangzhou,Jiaxing and Huzhou are unrivalled in the world;all under heaven draw their supply from it.”So observed the Ming Dynasty(1368-1644)agronomist Xu Guangqi in his Complete Treatise on Agricu... “The silk of Suzhou,Hangzhou,Jiaxing and Huzhou are unrivalled in the world;all under heaven draw their supply from it.”So observed the Ming Dynasty(1368-1644)agronomist Xu Guangqi in his Complete Treatise on Agriculture,capturing the undisputed dominance of east China in sericulture centuries ago. 展开更多
关键词 silk innovation China sericulture industry renaissance tradition xu guangqi
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Ten Thousand Miles Along the Silk Road:A Journey of Discovering Ningxia 认领 引用
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《China & The World Cultural Exchange》 2026年第1期48-53,共6页
The ancient Silk Road,stretching for thousands of miles,a nd spanning for millennia,bears the collective memory of prosperous trade and cultural exchange.In the 2nd century BCE,Zhang Qian,an envoy of the Han Dynasty,e... The ancient Silk Road,stretching for thousands of miles,a nd spanning for millennia,bears the collective memory of prosperous trade and cultural exchange.In the 2nd century BCE,Zhang Qian,an envoy of the Han Dynasty,embarked on a groundbreaking journey across the Eurasian continent.This marked the beginning of a grand epic of cultural exchange tied to the Silk Road.Almost simultaneously,countless merchant ships set sail from China's southeastern coast.They sailed through the Strait of Malacca,crossed the Indian Ocean,and arrived at the shores of the Red Sea.Finally,they reached East Africa and Europe. 展开更多
关键词 cultural exchange silk road ningxia zhang qian han dynasty trade maritime trade merchant ships
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Tactile Pleasures and Female Subjectivity in Kate Chopin’s A Pair of Silk Stockings 认领 引用
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作者 Mengyao Li 《Journal of Contemporary Educational Research》 2026年第5期329-336,共8页
This paper analyzes Kate Chopin’s novella A Pair of Silk Stockings using a dual perspective of sensory criticism and haptic aesthetics to shift the attention from the usual readings based on themes of consumerism and... This paper analyzes Kate Chopin’s novella A Pair of Silk Stockings using a dual perspective of sensory criticism and haptic aesthetics to shift the attention from the usual readings based on themes of consumerism and mother-daughter conflict.The paper proposes that the use of a sensorial lens to investigate the experiences of women in Kate Chopin’s literature would enable us to gain a more detailed appreciation of the nature of female subjectivity as portrayed in her writing.Using the concept of embodied perception in a detailed analysis of tactile encounters experienced by the character Mrs.Sommers,this paper attempts to illustrate how tactile pleasures enable her brief moments of embodied agency where she transcends her designated social roles. 展开更多
关键词 Kate Chopin A Pair of Silk Stockings Haptic aesthetics Sensory criticism Female subjec
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Silk Road Symphony:Connecting the World 2025 Maritime Silk Road International Cuitural Tourism Festival 认领 引用
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作者 无 《China & The World Cultural Exchange》 2026年第3期42-46,共5页
From December 9 to December 15z the 2025 Maritime Silk Road In ternational Cultural Tourism Festival themed"Silk Road Symphony:Connecting the Worlds was grandly held in Quanzhou.Grounded in Quanzhou's Maritim... From December 9 to December 15z the 2025 Maritime Silk Road In ternational Cultural Tourism Festival themed"Silk Road Symphony:Connecting the Worlds was grandly held in Quanzhou.Grounded in Quanzhou's Maritime Silk Road culture and Minnan(southern Fujian)culture,the cultural tourism festival featured three major themed sections:"Vitalizing Intangible Cultural Heritage","Global Harmony,/and"China-Chic Consumption".These sections played a magnificent symphony of cultural integration and people-to-people conn ection. 展开更多
关键词 maritime silk road intangible cultural heritageglobal Quanzhou cultural tourism festival cultural tourism cultural integration Intangible Cultural Heritage
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纤铠Silkcel SL交联整理对真丝织物防灰伤性能的优化 认领 引用
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作者 徐小平 于硕 +3 位作者 俞幼萍 程小霞 蒋鑫 刘佳 《印染助剂》 CAS 2026年第6期42-45,共4页
本研究采用新型交联助剂纤铠Silkcel SL对真丝织物进行防灰伤整理,通过单因素实验确定优化工艺为:助剂用量6%(omf),纯碱用量20 g/L,50℃浸渍处理30 min。扫描电镜(SEM)观测与机洗性能评估结果表明,整理后织物纤维表面光滑,未出现明显灰... 本研究采用新型交联助剂纤铠Silkcel SL对真丝织物进行防灰伤整理,通过单因素实验确定优化工艺为:助剂用量6%(omf),纯碱用量20 g/L,50℃浸渍处理30 min。扫描电镜(SEM)观测与机洗性能评估结果表明,整理后织物纤维表面光滑,未出现明显灰伤现象,灰伤等级由整理前的1级显著提升至4~5级。在染色后整理工艺中,色差DEcmc值可控制在0.5以内,有效兼顾了织物色光与手感。经工厂放大实验验证,整理的织物经30次水洗后,灰伤等级仍可维持在3~4级,耐洗性能达到进口可机洗真丝产品水平。本研究为真丝织物的机洗护理提供了一种可行的整理技术与工艺方案,具有较好的产业化应用前景。 展开更多
关键词 真丝织物 灰伤 原纤化
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Silk-YOLO:蚕丝被拉扯识别算法 认领 引用
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作者 陈柯含 张磊 +1 位作者 孙晓飞 谢佳伟 《江西师范大学学报（自然科学版）》 CAS 北大核心 2026年第1期69-77,共9页
为了提高对蚕丝被拉扯情况的识别率与识别效率,该文提出一种基于改进YOLOv11的目标检测模型(Silk-YOLO).首先,设计了一个新的多尺度卷积模块SilkConv,利用不同卷积核进行深度可分离卷积,增大模型对不同尺度的捕捉,在保留常规卷积提取空... 为了提高对蚕丝被拉扯情况的识别率与识别效率,该文提出一种基于改进YOLOv11的目标检测模型(Silk-YOLO).首先,设计了一个新的多尺度卷积模块SilkConv,利用不同卷积核进行深度可分离卷积,增大模型对不同尺度的捕捉,在保留常规卷积提取空间特征能力的同时减少冗余计算,解决在深度网络中的梯度消失问题;其次,添加了EMA注意力机制,在少量增加模型参数量的同时增强对特征的检测能力;最后,设计了C3k2_ABlock模块,实现了高效的上下文信息整合,从而进一步加强对蚕丝被拉扯的特征情况的处理.在自制数据集上,与YOLOv11n基础模型相比,改进后的模型将精度、召回率、mAP_(50)和mAP_(50~95)分别提高了2.6%、9.2%、5.1%和6.6%.Silk-YOLO相较于其他算法对蚕丝被拉扯情况检测效果更优. 展开更多
关键词 目标检测 蚕丝被 多尺度 特征增强
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Editorial: Special Issue on Frontiers in Marine Geology and Geophysics Along the Maritime Silk Road 认领 引用 被引量：1
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作者 LIANG Jie ZHANG Penghui +2 位作者 GOLSANAMI Naser ASIF Inam DHANASUVARNACHOTE Dhiti 《Journal of Ocean University of China》 SCIE CAS CSCD 2025年第6期1447-1449,共3页
1 Introduction The Maritime Silk Road, once a historic network of trade routes that connected continents and facilitated centuries of cultural and economic exchange, has become a region of profound scientific importan... 1 Introduction The Maritime Silk Road, once a historic network of trade routes that connected continents and facilitated centuries of cultural and economic exchange, has become a region of profound scientific importance. Stretching from East Asia to Europe and Africa, its marine environments are among the most complex and dynamic on Earth. This region encompasses diverse geological settings, including tectonically active zones, varied sedimentary basins, and extensive continental shelves. These features make it a unique natural laboratory for studying various geological and geophysical processes. 展开更多
关键词 sedimentary basins maritime silk road tectonically active zones marine environments continental shelves geological settings network trade routes cultural economic exchange
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Research on organized method and regulatory mechanism of cell cultured meat based on modified silk 认领 引用 被引量：1
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作者 Feng Yang Haijuan Hu +4 位作者 Yingying Li Shilei Li Wenting Liu Yu Qi Shouwei Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第9期3636-3657,共22页
Cell cultured meat has been extensively studied as an environmentally friendly,energy-saving and more effective technology.However,there are many technical bottlenecks,especially the regulatory mechanism and manufactu... Cell cultured meat has been extensively studied as an environmentally friendly,energy-saving and more effective technology.However,there are many technical bottlenecks,especially the regulatory mechanism and manufacturing method of in vitro myogenesis.Based on an edible modified silk protein scaffold,with 3D culturing,in situ differentiated and transcriptome analysis,this study describes novel scaffolds and fabrication methods for cell cultured meat.The results showed that the effective space and utilization efficiency for cell culture of the scaffold is 26–1000 that of the traditional culture dish;it could form a tissue-like structure.Transcriptomics revealed the regulatory pathways and key factors of different cycles.It clarifies that the multi-cycle process of myoblast myogenesis in vitro is different from the single feedback regulation in vivo.More importantly,a novel scaffold-based cell cultured meat manufacturing method was developed,further develop a new tissue culture solution that is different from existing cell culture meat production.For manufacturing processes,it provides a new cell culture meat technology system,provides a theoretical basis for the regulation of cell proliferation and muscle growth,and lays the technical foundation for in situ tissue culture of cell cultured meat in vitro. 展开更多
关键词 Modified silk protein Organized cell culture Cell proliferation Regulatory mechanisms Cell cultured meat production
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Consistency,distinction,and potential metabolic crosstalk of nitrogen mobilization-related genes in silk production and silk gland biology 认领 引用
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作者 Mei-Yan Yi Xu Yang +9 位作者 Man Wang Jing-Wei Chen Jia-Hao Xiang Li-Jun Xiang Lan-Sa Qian Dong-Bin Chen Yong-Ping Huang Xiao-Ling Tong Zu-Lian Liu Hui Xiang 《Zoological Research》 SCIE CAS CSCD 2025年第2期446-458,共13页
The domesticated silkworm(Bombyx mori)has evolved a highly efficient nitrogen utilization system to support silk production.The silk glands play a pleiotropic role in sequestering nitrogen resources for silk synthesis... The domesticated silkworm(Bombyx mori)has evolved a highly efficient nitrogen utilization system to support silk production.The silk glands play a pleiotropic role in sequestering nitrogen resources for silk synthesis,mitigating aminoacidemia by assimilating free amino acids,and reallocating nitrogen during metamorphosis through programmed cell death.However,the specific functions of nitrogen metabolism-related genes in this process remain unclear.Using CRISPR/Cas9-based gene editing,mutations were generated in glutamine synthetase(GS),glutamate synthetase(GOGAT),asparagine synthetase(AS),glutamate dehydrogenase(GDH)and glutamate oxaloacetate transaminase 1(GOT1).Disruption of GS,GOGAT,and AS consistently reduced silkworm cocoon and pupal weight and significantly down-regulated silk protein gene transcription,whereas GOT1 mutation had no such effect.GOGAT mutants exhibited abnormally enlarged silk glands,whereas GS and AS mutants showed delayed programmed cell death in the silk glands.In contrast,GOT1 mutants displayed normal silk gland morphology but were consistently smaller.Disruption of GS,GOGAT,and AS led to more extensive transcriptional changes,including altered expression of transcription factors in the silk glands,compared with GOT1 mutants.Both GS and GOGAT mutants exhibited up-regulation of AS and GDH,while only GOGAT mutants displayed elevated AS enzymatic activity,suggesting that GOGAT may compete with AS for glutamine in the silk glands to support silk protein synthesis.AS mutants showed significantly elevated GOT activity and up-regulation of several metabolic pathways,indicating that AS may functionally interact with GOT in regulating both silk gland development and programmed cell death during metamorphosis. 展开更多
关键词 Silkworm Nitrogen mobilization Silk gland Metamorphosis
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Ultrastrong silk fabric ionogel-sensor for strain/temperature/tactile multi-mode sensing 认领 引用
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作者 Shu Wang Jiangling Ning +9 位作者 Jianyu Pu Changjie Wei Yuping Yuan Songqi Yao Yuantao Zhang Ziwen Jing Chenxing Xiang Xinglong Gong Zhi Li Ning Hu 《Nano Materials Science》 EI CAS CSCD 2025年第3期316-325,共10页
Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with... Ionogels have demonstrated substantial applications in smart wearable systems,soft robotics,and biomedical engineering due to the exceptional ionic conductivity and optical transparency.However,achieving ionogels with desirable mechanical properties,environmental stability,and multi-mode sensing remains challenging.Here,we propose a simple strategy for the fabrication of multifunctional silk fabric-based ionogels(BSFIGs).The resulting fabric ionogels exhibits superior mechanical properties,with high tensile strength(11.3 MPa)and work of fracture(2.53 MJ/m3).And its work of fracture still has 1.42 MJ/m3as the notch increased to 50%,indicating its crack growth insensitivity.These ionogels can be used as sensors for strain,temperature,and tactile multimode sensing,demonstrating a gauge factor of 1.19 and a temperature coefficient of resistance of3.17/℃-1.Furthermore,these ionogels can be used for the detection of different roughness and as touch screens.The ionogels also exhibit exceptional optical transmittance and environmental stability even at80℃.Our scalable fabrication process broadens the application potential of these multifunctional ionogels in diverse fields,from smart systems to extreme environments. 展开更多
关键词 Silk fabric ionogel Mechanical properties Strain sensing Temperature sensing Tactile sensing
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