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Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up 认领 引用 被引量：3
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作者 Yan-Yao Du Wei Zhao +13 位作者 Xiang-Lin Zhou Mu Zeng Dan-Hui Yang Xing-Zhi Xie Si-Hong Huang Ying-Jia Jiang Wen-Han Yang Hu Guo Hui Sun Ji-Yang Liu Ping Liu Zhi-Guo Zhou Hong Luo Jun Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第7期1576-1581,共6页
Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,ne... Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,neuropsychiatric sequelae,and changes in brain function remain unknown.This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19(8 males and 11 females,aged 54.2±8.7 years).Fatigue and myalgia were persistent symptoms at the 1-year follow-up.The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls(7 males and 18 females,aged 50.5±11.6 years),COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation(ALFF)values in the left precentral gyrus,middle frontal gyrus,inferior frontal gyrus of operculum,inferior frontal gyrus of triangle,insula,hippocampus,parahippocampal gyrus,fusiform gyrus,postcentral gyrus,inferior parietal angular gyrus,supramarginal gyrus,angular gyrus,thalamus,middle temporal gyrus,inferior temporal gyrus,caudate,and putamen.ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores,and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization.The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors.This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae.This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University(approval No.2020 S004)on March 19,2020. 展开更多
关键词 amplitude of low-frequency fluctuation clinical study coronavirus disease 2019 follow-up functional magnetic resonance imaging long-term physical consequences neuropsychiatric sequelae resting‐state function
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Effective doctor-patient communication skills training optimizes functional organization of intrinsic brain architecture:a restingstate functional MRI study 认领 引用 被引量：2
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作者 Bing Zhang Ling Ni +10 位作者 Fangfang Wang Weiping Li Xin Zhang Xiaohua Gu Zuzana Nedelska Fei Chen Kun Wang Bin Zhu Renyuan Liu Jun Xu Jinfan Wang 《Journal of Biomedical Research》 CAS CSCD 2017年第6期486-493,共8页
We studied the influence of doctor-patient communication skills training on brain functional architecture using resting-state functional MRI（rs-fMRI） with a regional homogeneity（ReHo） method. Ten medical students ... We studied the influence of doctor-patient communication skills training on brain functional architecture using resting-state functional MRI（rs-fMRI） with a regional homogeneity（ReHo） method. Ten medical students participated in the study. A 1-year long doctor-patient communication skills training program was conducted. RsfMRI data were collected at baseline, one month and one year after training. There was a significant increase in the communication skills test average scores between baseline and 1-month duration of training（P〈0.001）. After one month of communication skills training, medical students had decreased ReHo in the right superior temporal gyrus compared with the baseline. After one year of communication skills training, students had increased ReHo in multiple regions and decreased ReHo in several regions（P 〈0.05, Alphasim corrected）. The change of ReHo values in the superior temporal gyrus negatively correlated with the change of communication skills scale score between one month after communication skills training and baseline（r=-0.734, P= 0.036）. The training program we used can be an effective approach of improving doctor-patient communication skills, and the training resulted in functional plasticity of the brain’s architecture toward optimizing locally functional organization. 展开更多
关键词 brain architecture function resting-state functional MRI（rs-fMRI） doctor-patient communication
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THE AUTOMATIC GENERATION OF LIMIT STATE FUNCTION OF HINGED STRUCTURE 认领 引用
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作者 车维毅 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1991年第12期1187-1193,共7页
In this paper, the theorem of structure continual variation of truss structure in the analysis of structure reliability is derived, and it is used to generate limit state function automatically. We can avoid repeated ... In this paper, the theorem of structure continual variation of truss structure in the analysis of structure reliability is derived, and it is used to generate limit state function automatically. We can avoid repeated assembly of global stiffness matrix and repeated inverse operations of the matrix caused by constant changes of structure topology. A new criterion of degenerate of the structure into mechanism is introduced. The calculation examples are satisfactory. 展开更多
关键词 hinged structure continual variation theorem limit state function
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Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis 认领 引用 被引量：7
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作者 Yu-Xiang Hu Jun-Rong He +7 位作者 Bo Yang Xin Huang Yu-Ping Li Fu-Qing Zhou Xiao-Xuan Xu Yu-Lin Zhong Jun Wang Xiao-Rong Wu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第11期1814-1820,共7页
AIM： To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality（DC） method.METHODS： In total, 38 patients with high myopia（HM... AIM： To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality（DC） method.METHODS： In total, 38 patients with high myopia（HM）（17 males and 21 females）, whose binocular refractive diopter were-6.00 to-7.00 D, and 38 healthy controls（17 males and 21 females）, closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance.RESULTS： Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule（P〈0.05）. In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus（P〈0.05）. However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance（P〉0.05）.CONCLUSION： HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients. 展开更多
关键词 high myopia degree centrality functional magnetic resonance imaging resting state
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Research Progress of Resting State Functional Magnetic Resonance Imaging in Patients with Insomnia 认领 引用
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作者 LI Jie CHEN Lixia +1 位作者 LYU Dongsheng MENG Fanyu 《外文科技期刊数据库（文摘版）医药卫生》 2021年第12期1220-1223,共4页
There is no widely accepted pathological mechanism and hypothesis for insomnia disorder, which results in the current clinical treatment can only be symptomatic treatment, but no causative treatment. Therefore, it is ... There is no widely accepted pathological mechanism and hypothesis for insomnia disorder, which results in the current clinical treatment can only be symptomatic treatment, but no causative treatment. Therefore, it is very important to study the pathogenesis of insomnia. The application of functional neuroimaging technology accelerates the study of insomnia disorder and provides an important technical means for the study of the pathological mechanism of insomnia. Research shows that the local consistency value, low-frequency amplitude value and functional connectivity of some brain regions in patients with insomnia disorder are changed. Therefore, it is very important to study the pathogenesis of insomnia. The application of functional neuroimaging technology accelerates the study of insomnia disorder and provides an important technical means for the study of the pathological mechanism of insomnia. This article will review the relevant literature on the changes of resting brain function in patients with insomnia, hoping to provide reference for the diagnosis and treatment of insomnia. 展开更多
关键词 insomnia disorder resting state functional magnetic resonance local consistency functional connec
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Age-related connectivity differences between attention deficit and hyperactivity disorder patients and typically developing subjects:a resting-state functional MRI study 认领 引用 被引量：2
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作者 Jisu Hong Bo-yong Park +1 位作者 Hwan-ho Cho Hyunjin Park 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第10期1640-1647,共8页
Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influen... Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored.We explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and adults.We collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network analysis.We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal centrality.The left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive function.The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients.These findings contribute to better understand how brain function influences the symptoms of ADHD. 展开更多
关键词 nerve regeneration attention deficit and hyperactivity disorder cognitive function connectivity resting-state f MRI Brainnetome Atlas whole brain analysis disease-aging interaction effect neuroscience neural regeneration
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Brain activity alterations in chronic cough:a resting-state functional magnetic resonance imaging study 认领 引用
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作者 CHEN Zhe 《China Medical Abstracts(Internal Medicine)》 2026年第1期33-34,共2页
Objective To explore the characteristics of altered brain functional activity in patients with chronic cough using resting-state functional magnetic resonance imaging(fMRI).Methods This was a prospective study.
关键词 altered brain functional activity chronic cough resting state functional magnetic resonance imaging prospective study brain activity alterations
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Analysis on social circuitry of brain function in children with ASD, ADHD, and comorbid conditions using resting-state functional connectivity magnetic resonance imaging 认领 引用
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作者 XI Yangyang 《China Medical Abstracts(Internal Medicine)》 2026年第2期127-128,共2页
Objective To investigate abnormal neural circuit patterns in children with autism spectrum disorder(ASD),attention deficit hyperactivity disorder(ADHD),and ASDADHD comorbidity,and to examine their associations with so... Objective To investigate abnormal neural circuit patterns in children with autism spectrum disorder(ASD),attention deficit hyperactivity disorder(ADHD),and ASDADHD comorbidity,and to examine their associations with social deficits.Methods A total of 212 children were prospectively recruited from the child and adolescent sub-cohort of the Autism Specialty Cohort at Nanjing Brain Hospital and were divided into four groups:ASD[n=55;aged 6-10 years,mean age(8.20±2.22)years],ADHD[n=50;aged 7-10 years,mean age(9.00±1.56)years];comorbidity[n=54;aged 6-10years,mean age(8.19±1.68)years],and typical development(TD)controls[n=53;aged 6-10 years,mean age(8.45±1.97)years]. 展开更多
关键词 magnetic resonance imaging attention deficit hyperactivity disorder brain function resting state functional connectivity autism spectrum disorder autism spectrum disorder asd attention deficit hyperactivity disorder adhd neural circuit patterns abnormal neural circuit patterns
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Imaging brain white matter function using resting-state functional MRI 认领 引用 被引量：2
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作者 Gong-Jun Ji Zaixu Cui +9 位作者 Ryan C.N.D’Arcy Wei Liao Bharat B.Biswal Qing Zhang Cheng Luo Yu-Feng Zang Zhaohua Ding Xi-Nian Zuo John C.Gore Kai Wang 《Science Bulletin》 SCIE EI CAS CSCD 2025年第9期1384-1388,共5页
White matter(WM)comprises approximately half of the human brain volume and is primarily composed of bundles of axons and glia.The axons conduct nerve impulses between gray matter(GM)to support information transmission... White matter(WM)comprises approximately half of the human brain volume and is primarily composed of bundles of axons and glia.The axons conduct nerve impulses between gray matter(GM)to support information transmission and coordination within brain networks or circuits.Despite the overwhelming emphasis of human brain imaging on GM,few would deny the importance of the functional contributions of WM to human cognition and behavior.For in vivo brain studies,diffusion magnetic resonance imaging(MRI)has been widely used to delineate WM fibers and measure their microstructural properties,but diffusion MRI reveals little about functional activity.For a long time,we have lacked an in vivo way to quantify functional metrics of wM.In contrast to the widespread application of functional MRI(fMRI)based on blood oxygenation-level-dependent(BOLD)signals to assess GM functions[1],BOLD effects in WM have been regarded as noise or nuisance variables in most neuroimaging studies. 展开更多
关键词 human brain imaging white matter wm comprises gray matter gm diffusion MRI functional MRI blood oxygenation level dependent signals resting state functional MRI brain white matter
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The functional state of athletes who have undergone coronavirus infection(COVID-19) 认领 引用
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作者 Victoria Zaborova Irina Lazareva +6 位作者 Kira Kryuchkova Christina Popova Vitaly Rybakov Dmitry Shestakov Valerio Bonavolonta Laura Guidetti Giovanna Zimatore 《Sports Medicine and Health Science》 CSCD 2025年第6期453-459,共7页
This study aimed to investigate the energy supply of athletes,who had a mild form of coronavirus infection(COVID-19)under cycling ergometric load(CEL)to substantiate the timing of recovery,as well as to determine the ... This study aimed to investigate the energy supply of athletes,who had a mild form of coronavirus infection(COVID-19)under cycling ergometric load(CEL)to substantiate the timing of recovery,as well as to determine the volume and intensity of physical activity.Eighty-seven athletes aged from 18 to 28 years old,involved in cyclic sports,were examined.Group I consisted of 52 athletes with COVID-19,and group Ⅱ consisted of 37 healthy self-isolating athletes.In addition to the comprehensive examination,the tested athletes underwent special examinations:the study of diagnostic material using methods of nucleic acid amplification,spirography and spiroergometry,electrocardiography(ECG),and CEL.The results of athletes from both groups did not differ significantly(p>0.5)in the 1st,2nd,and 3rd examinations.The second examination revealed a discrepancy between functional reserves and the load performed,as evidenced by the difference in the recovery rate of most indicators,the results of the third examination in the long-term period(6 months)showed that the athletes of the first group did not have any violations of the parameters of the respiratory function(RF)and cardiovascular system at rest,after performing CEL,as well as in the recovery period.The results suggest that the full resumption of training loads and participation in competitions are possible only with the complete normalization of the functional state of the cardiorespiratory system.The most informative indicators are:minute ventilation(V E),heart rate(HR),oxygen pulse(OP),and coefficient of oxygen utilization(COU). 展开更多
关键词 Functional state Coronavirus infection COVID-19 Athletes Cycling ergometric load Spirography Spiroergometry
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Brain functional connectivity network studies of acupuncture: a systematic review on resting-state fMRI 认领 引用 被引量：70
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作者 Rong-lin Cai Guo-ming Shen +1 位作者 Hao Wang Yuan-yuan Guan 《Journal of Integrative Medicine》 SCIE CAS CSCD 2018年第1期26-33,共8页
Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain f... Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research had also shown that acupuncture could adjust the limbic-paralimbic-neocortical network, brainstem, cerebellum, subcortical and hippocampus brain areas. Conclusion： It can be presumed that the functional connectivity network is closely related to the mech- anism of acupuncture, and central integration plays a critical role in the acupuncture mechanism. 展开更多
关键词 Resting-state functional magnetic resonance Acupuncture Functional connectivity Functional network Complementary medicine Alternative medicine
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Reduction in interhemispheric functional connectivity in the dorsal visual pathway in unilateral acute open globe injury patients: a resting-state fMRI study 认领 引用 被引量：6
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作者 Lei Ye Ran Wei +9 位作者 Xin Huang Wen-Qing Shi Qi-Chen Yang Qing Yuan Pei-Wen Zhu Nan Jiang Biao Li Qiong Zhou Fu-Qing Zhou Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第6期1056-1060,共5页
This study investigated the changes in interhemispheric functional connectivity （FC） of the whole brain in open globe injury （OGI） patients, using voxel-mirrored homotopic connectivity （VMHC）, and their relation... This study investigated the changes in interhemispheric functional connectivity （FC） of the whole brain in open globe injury （OGI） patients, using voxel-mirrored homotopic connectivity （VMHC）, and their relationships with clinical features. Totally, 16 male and 2 female acute OGI patients and 18 sex, age, and education-matched healthy volunteers were enrolled in the study. All subjects were scanned through functional magnetic resonance imaging （fMRI）. Receiver operating characteristic （ROC） curves analyses had been used to identify the VMHC in these brain areas could be used as biomarkers to distinguish OGI and from healthy control （HC）. The mean VMHC values in multiple brain areas and clinical OGI manifestations were evaluated with a Pearson correlation analysis. OGI patients had significantly decreased VMHC in the bilateral calcarine/lingual/cuneus （BA18, 19, 30） and middle occipital gyrus （BA18, 19）. The OGI patients had abnormal interhemispheric FC in the dorsal visual pathway, which may represent the pathophysiological mechanism that underlies acute vision loss after OGI. 展开更多
关键词 unilateral acute open globe injury voxelmirrored homotopic connectivity resting state functional magnetic resonance imaging
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Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study 认领 引用 被引量：24
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作者 LIU Jun GAO Xue-ping +4 位作者 Isoken Osunde LI Xin ZHOU Shun-ke ZHENG Hui-rong LI Ling-jiang 《Chinese Medical Journal》 SCIE CAS 2010年第14期1904-1908,共5页
Background Internet addition disorder （lAD） is currently becoming a serious mental health problem among Chinese adolescents. The pathogenesis of lAD, however, remains unclear. The purpose of this study applied regio... Background Internet addition disorder （lAD） is currently becoming a serious mental health problem among Chinese adolescents. The pathogenesis of lAD, however, remains unclear. The purpose of this study applied regional homogeneity （ReHo） method to analyze encephalic functional characteristic of lAD college students under resting state. Methods Functional magnetic resonanc image （fMRI） was performed in 19 lAD college students and 19 controls under resting state. ReHo method was used to analyze the differences between the average ReHo in two groups. Results The following increased ReHo brain regions were found in lAD group compared with control group： cerebellum, brainstem, right cingulate gyrus, bilateral parahippocampus, right frontal lobe （rectal gyrus, inferior frontal gyrus and middle frontal gyrus）, left superior frontal gyrus, left precuneus, right postcentral gyrus, right middle occipital gyrus, right inferior temporal gyrus, left superior temporal gyrus and middle temporal gyrus. The decreased ReHo brain regions were not found in the lAD group compared with the control group. Conclusions There are abnormalities in regional homogeneity in lAD college students compared with the controls and enhancement of synchronization in most encephalic regions can be found. The results reflect the functional change of brain in lAD college students. The connections between the enhancement of synchronization among cerebellum, brainstem, limbic lobe, frontal lobe and apical lobe may be relative to reward pathways. 展开更多
关键词 internet addiction disorder resting state regional homogeneity functional magnetic resonance image
Decreased regional homogeneity in major depression as revealed by resting-state functional magnetic resonance imaging 认领 引用 被引量：32
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作者 PENG Dai-hui JIANG Kai-da +5 位作者 FANG Yi-ru XU Yi-feng SHEN Ting LONG Xiang-yu LIU Jun ZANG Yu-feng 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第3期369-373,共5页
Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown wi... Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity （ReHo） in depression by resting-state functional magnetic resonance imaging （fMRI）.Methods Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole brain.Results ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression.Conclusions Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe,and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression. 展开更多
关键词 depression first episode functional magnetic resonance imaging resting state regional homogeneity
Amplitude of Low-frequency Oscillations in Parkinson's Disease: A 2-year Longitudinal Resting-state Functional Magnetic Resonance Imaging Study 认领 引用 被引量：13
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作者 Xiao-Fei Hu Jiu-Quan Zhang +6 位作者 Xiao-Mei Jiang Chao-Yang Zhou Lu-Qing Wei Xun-Tao Yin Jing Li Yan-Ling Zhang Jian Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第5期593-601,共9页
Background：Neuroimaging studies have found that functional changes exist in patients with Parkinson＇s disease （PD）.However,the majority of functional magnetic resonance imaging （fMRI） studies in patients with PD... Background：Neuroimaging studies have found that functional changes exist in patients with Parkinson＇s disease （PD）.However,the majority of functional magnetic resonance imaging （fMRI） studies in patients with PD are task-related and cross-sectional.This study investigated the functional changes observed in patients with PD,at both baseline and after 2 years,using resting-state fMRI.It further investigated the relationship between whole-brain spontaneous neural activity of patients with PD and their clinical characteristics.Methods：Seventeen patients with PD underwent an MRI procedure at both baseline and after 2 years using resting-state fMRI that was derived from the same 3T MRI.In addition,20 age-and sex-matched,healthy controls were examined using resting-state fMRI.The fractional amplitude of low-frequency fluctuation （fALFF） approach was used to analyze the fMRI data.Nonlinear registration was used to model within-subject changes over the scanning interval,as well as changes between the patients with PD and the healthy controls.A correlative analysis between the fALFF values and clinical characteristics was performed in the regions showing fALFF differences.Results：Compared to the control subjects,the patients with PD showed increased fALFF values in the left inferior temporal gyrus,right inferior parietal lobule （IPL） and right middle frontal gyrus.Compared to the baseline in the 2 years follow-up,the patients with PD presented with increased fALFF values in the right middle temporal gyrus and right middle occipital gyrus while also having decreased fALFF values in the right cerebellum,right thalamus,right striatum,left superior parietal lobule,left IPL,left precentral gyrus,and left postcentral gyrus （P 〈 0.01,after correction with AlphaSim）.In addition,the fALFF values in the right cerebellum were positively correlated with the Unified PD Rating Scale （UPDRS） motor scores （r =0.5 l,P 〈 0.05,uncorrected） and the change in the UPDRS motor score （r =0.61,P 〈 0.05,uncorrected）.Conclusions：The baseline and longitudinal changes of the fALFF values in our study suggest that dysfunction in the brain may affect the regions related to cortico-striato-pallido-thalamic loops and cerebello-thalamo-cortical loops as the disease progresses and that alterations to the spontaneous neural activity of the cerebellum may also play an important role in the disease＇s progression in patients with PD. 展开更多
关键词 Functional Magnetic Resonance Imaging Longitudinal Parkinson＇s Disease Resting State
Wave functions of a new kind of nonlinear single-mode squeezed state 认领 引用
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作者 范洪义 笪诚 陈俊华 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第12期34-37,共4页
We explore the theoretical possibility of extending the usual squeezed state to those produced by nonlinear singlemode squeezing operators. We derive the wave functions of exp[-（ig/2）（（1-X2）1/2P ＋ P（1-X2）1/2）... We explore the theoretical possibility of extending the usual squeezed state to those produced by nonlinear singlemode squeezing operators. We derive the wave functions of exp[-（ig/2）（（1-X2）1/2P ＋ P（1-X2）1/2）]｜0 in the coordinate representation. A new operator＇s disentangling formula is derived as a by-product. 展开更多
关键词 wave functions nonlinear single-mode squeezed states coordinate representation disentangling formula
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Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study 认领 引用 被引量：5
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作者 Qiu En-chao Yu Sheng-yuan +3 位作者 Liu Ruo-zhuo Wang Yan Ma Lin Tian Li-xia 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第4期705-709,共5页
Background Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache （CH）.The aim of our study was to assess the changes in brain activity in CH patients by the regiona... Background Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache （CH）.The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique.Methods The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during “in attack” and “out of attack” periods and 12 age- and sex-matched normal controls.The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software.Results Altered regional homogeneity was detected in the anterior cingulate cortex,the posterior cingulate cortex,the prefrontal cortex,insular cortex,and other brain regions involved in pain processing and modulation among different groups.Conclusion It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH. 展开更多
关键词 cluster headache functional magnetic resonance imaging resting state, regional homogeneity
The vital point of the Parameters of Morpho-functional State of Gymnasts for the Assessment of Physical Development at the Stage of Sports Perfection 认领 引用
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作者 Zakharyeva Natalia Nikolaevna 《Chinese Business Review》 2021年第2期56-65,共10页
The article presents the data of the assessment of the physical development and functional state of highly qualifiedgymnasts engaged in rhythmic gymnastics. It was found that high-skilled gymnasts have heterogeneity o... The article presents the data of the assessment of the physical development and functional state of highly qualifiedgymnasts engaged in rhythmic gymnastics. It was found that high-skilled gymnasts have heterogeneity ofsomatotypes determined according to the B. Heath-J. Carter scheme and heterogeneity of types of autonomousnervous regulation of heart rate variability, systolic, diastolic blood pressure and respiration, determined on thespiroarteriorhythmocardiograph device. Highly qualified gymnasts have vago- and normotonic types of regulationof heart rate variability;normal-sympathetic-and hypersympathicotonic types of regulation of the variability ofsystolic blood pressure and diastolic blood pressure, vagotonic type of regulation of the variability of the respiratoryrhythm. Statistically significant differences gymnasts, successful in the medal standings at the internationalcompetitions and gymnasts participating, but not in high prizes in competitions, consist in the ability to resistfatigue while performing strenuous mental work (differences were revealed in 10-letter “Mental performance” at aconstant speed (p > 0.0001), and 3-letter test (p > 0.001)), data stabilometric test “Target” indicator “Time stabilityon the left foot” (R > 0.039) with the advantage of a high performing gymnasts artists. Fleshed out the possibility ofusing the parameters of the morphofunctional state of gymnasts in training for the qualitative evaluation of thephysical development of gymnasts, evaluation set their sports uniforms indicated the possibility of developing thereference parameters of the morphofunctional status of gymnasts and recommendations on the frequency of thesurvey of morphological and functional status of gymnasts involved in rhythmic gymnastics. 展开更多
关键词 rhythmic gymnastics highly qualified athletes anthropometry somatotype functional state sports form
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Study on Functional Connectivity of Resting State Brain in First Episode Schizophrenic Auditory Hallucinations 认领 引用
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作者 WANG Yanjiao SUN Yutao +1 位作者 LU Xiuchun LIU Yanbin 《外文科技期刊数据库（文摘版）医药卫生》 2021年第11期013-015,共3页
Objective: in this paper, the functional connectivity of the resting state brain in first-episode schizophrenia patients with auditory hallucinations was studied. Methods: according to the DDSM -IV schizophrenia diagn... Objective: in this paper, the functional connectivity of the resting state brain in first-episode schizophrenia patients with auditory hallucinations was studied. Methods: according to the DDSM -IV schizophrenia diagnostic criteria, 94 patients with first schizophrenic auditory hallucinations and 94 healthy patients were selected as control. All subjects underwent clinical evaluation and resting-state functional magnetic resonance (FMRI) scans, and the differences between the two groups were analyzed and compared. Results: compared to control group, patients with first-episode schizophrenia auditory hallucination itself left superior temporal gyrus, the ipsilateral medial prefrontal function and connection of side guide vane fall further, at the same time, to the left side of the patients with first-episode schizophrenia hallucinations Heschl back with ipsilateral medial prefrontal function and connection of the contralateral temporal gyrus, showed a trend of decline, in addition, for the right of HG, it was also functionally connected to the left middle temporal gyrus and showed a declining trend. Conclusion: in the early stages of schizophrenia, there are serious abnormal connectivity between different brain regions, especially between the two sides of the brain, and there is also an abnormal pattern of "disconnection", which indicates that there are serious abnormalities in the integration function of the brain in the first episode of schizophrenia. 展开更多
关键词 first-episode schizophrenia auditory hallucinations resting state brain functional connectivity
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手井穴刺络放血对丘脑及相关皮层脑区功能的多维度影响研究 认领 引用 被引量：1
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作者 赵佳玥 柴超 +9 位作者 姚港林 郭义 赵亚丹 张紫辰 杨元祯 骆雨 苗诗雨 张朝阳 黄菁 徐枝芳 《中国针灸》 CAS CSCD 北大核心 2026年第4期500-506,共7页
目的:基于静息态功能性磁共振成像(rs-fMRI)技术,探讨手井穴刺络放血对健康受试者丘脑-皮层网络功能的调控作用,从多维度脑功能指标分析其改善脑功能状态、促进脑保护的潜在神经机制。方法:采用自身前后对照设计,纳入30名健康受试者,完... 目的:基于静息态功能性磁共振成像(rs-fMRI)技术,探讨手井穴刺络放血对健康受试者丘脑-皮层网络功能的调控作用,从多维度脑功能指标分析其改善脑功能状态、促进脑保护的潜在神经机制。方法:采用自身前后对照设计,纳入30名健康受试者,完成rs-fMRI扫描后在操作床上接受手井穴刺络放血(按右手→左手、拇指→小指顺序依次对少商、商阳、中冲、关冲、少冲、少泽刺络放血),干预完成后继续进行rs-fMRI扫描。分析干预前后健康受试者大脑低频波动振幅(ALFF)和局部一致性(ReHo)、以丘脑为种子点的全脑功能连接(FC)、脑血流量。结果:与干预前比较,健康受试者干预后双侧颞上回、双侧颞中回、双侧楔前叶及双侧丘脑ALFF降低(P0.05)。结论:手井穴刺络放血可调节大脑功能状态,一方面抑制丘脑及高阶皮层节点的过度活跃与异常同步放电,另一方面重塑丘脑功能连接网络。 展开更多
关键词 井穴 刺络放血 静息态功能性磁共振成像 脑功能调节 丘脑 皮层
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