On 28 March 2025,a strong Mw 7.7 earthquake struck the seismic gap in the central section of the Sagaing Fault in Myanmar,causing significant damages and casualties in Myanmar and neighboring countries.Major earthq...On 28 March 2025,a strong Mw 7.7 earthquake struck the seismic gap in the central section of the Sagaing Fault in Myanmar,causing significant damages and casualties in Myanmar and neighboring countries.Major earthquakes like this are expected to transfer stresses to nearby active regions and change their seismic hazards in the near future.In this study,based on a stratified viscoelastic model and a coseismic slip model,we calculated the co-and post-seismic Coulomb stress change(△CFS)imparted by the Mw 7.7 Myanmar earthquake to the main active faults in the adjacent southwestern Yunnan region in China.Our results show that five fault segments experience up to 3 kPa of coseismic stress increase,including the Longling-Lancang Fault,the Nantinghe Fault,the Menglian Fault,the Heihe Fault,and the Red River Fault,respectively.The pattern of postseismic △CFS is similar to that of coseismic △CFS,suggesting that with the increasing elapsed time,the stress level continues to increase in these fault zones.The coseismic auxiliary stress fields show that the orientation of the principal tensile stress is predominantly NE-SW in the northern part of the southwestern Yunnan region,and shows clockwise rotation to NW-SE in the south.This stress regime controls the additional slip motion,consistent with that reflected by the coseismic shear stress change.Combined with other geophysical and geodetic data,we propose that more attention should be paid to the Longling-Lancang Fault,the Nantinghe Fault,the Menglian Fault,and the Heihe Fault,potential candidates for the next strong earthquakes in this region.展开更多
In-situ stress is a key parameter for underground mine design and rock stability analysis.The borehole overcoring technique is widely used for in-situ stress measurement,but the rheological recovery deformation of roc...In-situ stress is a key parameter for underground mine design and rock stability analysis.The borehole overcoring technique is widely used for in-situ stress measurement,but the rheological recovery deformation of rocks after stress relief introduces errors.To improve accuracy,this study proposes an in-situ stress solution theory that incorporates time-dependent stress relief effects.Triaxial stepwise loadingunloading rheological tests on granite and siltstone established quantitative relationships between instantaneous elastic recovery and viscoelastic recovery under different stress levels,confirming their impact on measurement accuracy.By integrating a dual-class elastic deformation recovery model,an improved in-situ stress solution theory was derived.Additionally,accounting for the nonlinear characteristics of rock masses,a determination method for time-dependent nonlinear mechanical parameters was proposed.Based on the CSIRO hollow inclusion strain cell,time-dependent strain correction equations and long-term confining pressure calibration equations were formulated.Finally,the proposed theory was successfully applied at one iron mine(736 m depth)in Xinjiang,China,and one coal mine(510 m depth)in Ningxia,China.Compared to classical theory,the calculated mean stress values showed accuracy improvements of 6.0%and 9.4%,respectively,validating the applicability and reliability of the proposed theory.展开更多
The structural integrity of multi-pass welded austenitic stainless steel pipes is significantly influenced by the synergistic effect of multi-scale residual stresses.Macroscopic(TypeⅠ)stresses drive distortion and st...The structural integrity of multi-pass welded austenitic stainless steel pipes is significantly influenced by the synergistic effect of multi-scale residual stresses.Macroscopic(TypeⅠ)stresses drive distortion and stress corrosion cracking(SCC),while microscopic(TypeⅡ)stresses,arising from intergranular incompatibility,control micro-damage initiation.However,due to limitations of traditional techniques,such as lack of microscopic resolution or difficulty in handling large components,the spatial distribution of stresses within the complex heat-affected zone(HAZ)remains difficult to obtain experimentally.This study applies synchrotron radiation-based Double Exposure Method(DEM)to directly measure and decouple TypeⅠand TypeⅡresidual stress fields in multi-pass welded SUS316 steel pipe.High-resolution spatial distribution maps of the two decoupled stress types in the HAZ are presented.The results reveal a highly heterogeneous and complementary distribution:TypeⅠstress exhibits a typical macroscopic gradient,while TypeⅡstress shows strong local variations at the grain scale,especially in the microstructure transition region near the fusion boundary.The results further show that the initiation of SCC is governed by local TypeⅡstresses,whereas subsequent crack propagation is driven by far-field TypeⅠstresses.This experimental insight into the decoupled multi-scale stress state provides a direct pathway for accurately assessing weld integrity and clarifying the drivers of SCC in critical industrial components such as nuclear power plants.展开更多
FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most importan...FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most important properties of FeMnSi-based SMA aseismic materials.However,the low-cycle fatigue behavior of such SMAs,especially the stress-controlled low-cycle fatigue behavior(with ratchetting effect),has not been clearly understood.In this work,the low-cycle fatigue behavior of the FeMnSiCrNi SMAs subjected to stress-controlled cyclic tension–compression loads is investigated,and the effects of temperature,loading frequency,stress amplitude,and stress ratio are addressed.By analyzing the cyclic stress–strain response,fatigue fracture surface morphology,dissipation energy,ratchetting strain,and equivalent damping ratio,the mechanisms behind the temperature-,loading frequency-,stress amplitude-,and stress ratio-dependent low-cycle fatigue behavior are discussed.The results show that the plasticity,martensitic transformation,and/or the ratchetting strain caused by their tension–compression asymmetry are the decisive factors affecting the low-cycle fatigue behavior of FeMnSiCrNi SMAs.展开更多
The dual alloy turbine disk can fully leverage the advantages of dissimilar materials and has broad application prospects.Multi-material topology optimization(MMTO)provides possibilities for its innovative design.Howe...The dual alloy turbine disk can fully leverage the advantages of dissimilar materials and has broad application prospects.Multi-material topology optimization(MMTO)provides possibilities for its innovative design.However,the coupling between multi-material design variables and centrifugal loads poses challenges,in-cluding insufficient stress prediction accuracy,ineffective stress control,and difficulties in optimization con-vergence.Therefore,a new MMTO method that considers accurate stress prediction and control under cen-trifugal loads is proposed herein.The core ideas are as follows.(1)Introducing the multi-material predicted density to reduce the number of gray elements,proposing a multi-material transition factor for flexible se-lection of stiffness matrix interpolation,and thus developing an innovative accurate multi-material stress prediction method.(2)By modifying the normalized global stress method and utilizing a fixed step size to update the multi-material global stress relaxation coefficient,the maximum stress of the design domain is effectively controlled.(3)Deriving the stress sensitivity of axisymmetric problems under the complex coupling of cen-trifugal loads and multi-material design variables to improve the optimization convergence of stresses.Then MMTO for a turbine disk is conducted using two popular alloys(GH4169 and K418B).The results show that the proposed MMTO method effectively controls maximum stress,fully utilizes the advantages of both alloys and achieves a novel dual-alloy turbine disk structure.展开更多
The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins.However,if the unfolded protein response...The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins.However,if the unfolded protein response fails to restore endoplasmic reticulum homeostasis,it can trigger proinflammatory and pro-death signals,which are implicated in various malignancies and are currently being investigated for their role in retinal degenerative diseases.This paper reviews the role of the unfolded protein responsein addressing endoplasmic reticulumstress in retinal degenerative diseases.The accumulation of ubiquitylated misfolded proteins can lead to rapid destabilization of the proteome and cellular demise.Targeting endoplasmic reticulum stress to alleviate retinal pathologies involves multiple strategies,including the use of chemical chaperones such as 4-phenylbutyric acid and tauroursodeoxycholic acid,which enhance protein folding and reduce endoplasmic reticulum stress.Small molecule modulators that influence endoplasmic reticulum stress sensors,including those that increase the expression of the endoplasmic reticulum stress regulator X-box binding protein 1,are also potential therapeutic agents.Additionally,inhibitors of the RNAse activity of inositol-requiring transmembrane kinase/endoribonuclease 1,a key endoplasmic reticulum stress sensor,represent another class of drugs that could prevent the formation of toxic aggregates.The activation of nuclear receptors,such as PPAR and FXR,may also help mitigate ER stress.Furthermore,enhancing proteolysis through the induction of autophagy or the inhibition of deubiquitinating enzymes can assist in clearing misfolded proteins.Combination treatments that involve endoplasmicreticulum-stress-targeting drugs and gene therapies are also being explored.Despite these potential therapeutic strategies,significant challenges remain in targeting endoplasmic reticulum stress for the treatment of retinal degeneration,and further research is essential to elucidate the mechanisms underlying human retinal diseases and to develop effective,well-tolerated drugs.The use of existing drugs that target inositol-requiring transmembrane kinase/endoribonuclease 1 and X-box binding protein 1 has been associated with adverse side effects,which have hindered their clinical translation.Moreover,signaling pathways downstream of endoplasmic reticulum stress sensors can contribute to therapy resistance.Addressing these limitations is crucial for developing drugs that can be effectively used in treating retinal dystrophies.In conclusion,while the unfolded protein response is a promising therapeutic target in retinal degenerative diseases,additional research and development efforts are imperative to overcome the current limitations and improve patient outcomes.展开更多
Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenar...Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.展开更多
The use of fiber-reinforced polymer(FRP)jackets or tubes as confining devices can significantly improve the compressive performance of ultra-high-performance concrete(UHPC).For FRP-confined UHPC,an analysis-oriented s...The use of fiber-reinforced polymer(FRP)jackets or tubes as confining devices can significantly improve the compressive performance of ultra-high-performance concrete(UHPC).For FRP-confined UHPC,an analysis-oriented stress–strain model is essential for a comprehensive understanding of its compressive behavior and the development of design models.Although several analysis-oriented stress–strain models have been developed for FRP-confined normal-strength concrete(NSC),such models for FRP-confined UHPC are still lacking.In this study,an experiment is conducted to investigate the failure mechanism of UHPC confined with FRP under concentric compression,and the stress–strain behavior of the FRP-confined UHPC is analyzed using the stress–strain models of actively-confined UHPC.Results showed that the stress-path-independency assumption,which has been proven to apply to FRP-confined NSC,was inapplicable to FRP-confined UHPC.By modifying the confining pressure to consider the influence of stress-path dependency,an analysis-oriented model was proposed.The proposed model was verified using a collected test database.The results show that the proposed model accurately predicted the stress–strain behavior of FRP-confined UHPC.展开更多
Background:Post-traumatic stress disorder(PTSD)is a complicated neuropsychiatric disorder that is marked by long-term neuroinflammation,oxidative stress,and poor neuroplasticity in stress-sensitive brain areas.Hesperi...Background:Post-traumatic stress disorder(PTSD)is a complicated neuropsychiatric disorder that is marked by long-term neuroinflammation,oxidative stress,and poor neuroplasticity in stress-sensitive brain areas.Hesperidin is a citrus-derived flavanone glycoside that has been reported to have multitarget neuroprotective effects with antioxidant,anti-inflammatory,and neurotrophic regulatory activities.However,its integrated effects across convergent pathological pathways in validated PTSD models remain insufficiently defined.Methods:Male Wistar rats were subjected to the single prolonged stress(SPS)paradigm and treated with hesperidin(50,100,and 200 mg/kg),fluoxetine(20 mg/kg),or vehicle for 14 days.Biochemical assessments(malondialdehyde[MDA],catalase[CAT],superoxide dismutase[SOD])and immunohistochemical measurements of neuronal and glial integrity(Neu N,glial fibrillary acidic protein[GFAP],brain-derived neurotrophic factor[BDNF])in the hippocampus,amygdala,and prefrontal cortex were performed.Results:SPS exposure induced marked oxidative imbalance,evidenced by increased MDA levels and reduced CAT activity,alongside significant upregulation of tumor necrosis factorα(TNF-α),interleukin 6(IL-6),and IL-1β,increased astrocytic reactivity(GFAP),and reduced BDNF expression.Hesperidin treatment significantly attenuated lipid peroxidation,partially restored CAT activity,and suppressed pro-inflammatory cytokines,with the most pronounced effect observed for IL-1β.Notably,hesperidin reduced astrocytic activation and preserved neuronal morphology,while enhancing BDNF expression in a dose-dependent manner,with optimal effects at 50–100 mg/kg.Conversely,there was little group variation in the activity of SOD,implying pathwayselective redox regulation.Conclusion:Hesperidin has multipathway,coordinated,modulatory effects on oxidative stress,neuroinflammation,glial activation,and neurotrophic signaling in the SPS model of PTSD.These findings support its utility as a mechanistic probe for interrogating convergent stress-related neuropathological pathways.展开更多
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.展开更多
Due to the unique geological structure in the Guizhou region,issues such as stress concentration and inefficient resource utilization efficiency arise during repeated mining of close-distance coal seam.This study focu...Due to the unique geological structure in the Guizhou region,issues such as stress concentration and inefficient resource utilization efficiency arise during repeated mining of close-distance coal seam.This study focuses on the Longfeng Coal Mine in Guizhou,investigating the evolution of stress arches and abutment pressure distribution under repeated mining conditions through similarity simulations,numerical simulations,and theoretical analysis.The study introduces a novel composite stress arch model,which more accurately represents stress evolution under complex mining conditions compared to traditional single arch theories.The model highlights the gradual transformation of a single stress arch into a composite structure,accounting for the increasing complexity of the stress distribution.Based on these evolution characteristics,a mechanical model of composite arches under nonlinear loading was developed.The calculation results and field monitoring data show that after repeated mining,the stop-mining coal pillar width should be optimized between 65 and 70 m.The research reveals the coupling relationship between the evolution of composite arches and the distribution of abutment pressure,which aids in optimizing coal pillar design,enhancing resource recovery rates,and ensuring the stability of roadways and stopes.展开更多
The growing burial depth increases the potential risk of ground stress-induced coal and rock dynamic disasters in coal mining.This study attempts to use microseismic and computed tomography(MS-CT)to quantitatively cha...The growing burial depth increases the potential risk of ground stress-induced coal and rock dynamic disasters in coal mining.This study attempts to use microseismic and computed tomography(MS-CT)to quantitatively characterize the stress field in coal seam areas.A comprehensive approach encompassing laboratory experiments,numerical simulations,and field investigations was employed to accomplish this objective.The experimental findings suggest a power function relationship between the wave velocity of coal and stress.The model relating wave velocity ratio to stress proves more suitable for research on stress field quantification.This model captures the positive correlation between wave velocity and stress changes and eliminates the influence of sample differences through normalization,rendering the fitting parameter b applicable in the field.This paper takes the No.22 coal seam of Jinjia coal mine as the research object;MS-CT technology was used to generate the cloud map of wave velocity field distribution in the 11224 working face and combined with the experimentally established relational model to relate the wave velocity ratio to the stress and calculate the results of quantitative characterization of the regional stress.At the same time,a detailed three-dimensional numerical model was established and simulated to obtain the stress distribution in the 11224 working face area.Comparison of the simulated stress field results with the quantitative results of MS-CT shows that the general trend is basically the same,and the stress is higher in the area with greater burial depth.The area affected by the overlying goaf has lower stress in the coal seam.The maximum error value of the two is within±2 MPa,and the correlation coefficient is 0.79,indicating a strong correlation.Therefore,the MS-CT technique combined with the experimental wave velocity-stress coupling relationship model can determine the stress field distribution and realize the quantitative stress characterization.This provides a crucial foundation for analyzing the mechanical model of coal seam instability and calculating the judgment index of coal-rock dynamic disaster excitation.展开更多
Strigolactones (SLs) are a group of phytohormones that enhance hyphal branching of arbuscular mycorrhizal fungi (AMF), promote seed germination of parasitic plants, and influence plant growth, development, and stress ...Strigolactones (SLs) are a group of phytohormones that enhance hyphal branching of arbuscular mycorrhizal fungi (AMF), promote seed germination of parasitic plants, and influence plant growth, development, and stress acclimation. SLs improve plant stress resilience by modulating shoot and root architecture, photosynthesis, nutrient homeostasis, and antioxidant defense. Under nutrient deficiency, SL accumulation enhances AMF colonization and triggers the expression of genes related to the nutrient starvation response. When subjected to drought, SLs mitigate water loss by modulating stomatal density and closure, cell membrane integrity, and anthocyanin biosynthesis. SLs also mitigate salinity and heavy metal stresses by maintaining ion homeostasis, while conferring thermotolerance and enhancing chilling tolerance. In this review, we highlight recent advances in SLs and their mechanisms in plant responses to environmental stresses, including nutrient deficiencies, drought, salinity, extreme temperatures, metal toxicity, herbivore attack, and pathogen infection. We further discuss how SLs interact with other phytohormones to coordinate the physiological, biochemical, and molecular regulatory events critical for plant acclimation to abiotic and biotic stresses.展开更多
Excavation causes stress redistribution and affects the stress path during the shearing process of rock.The shear strength of rock varies under different stress paths,and the presence of defects reduces the shear stre...Excavation causes stress redistribution and affects the stress path during the shearing process of rock.The shear strength of rock varies under different stress paths,and the presence of defects reduces the shear strength.To further investigate this phenomenon,this study investigates the shear behaviour of rocks with different shear surface integrities under the influenceof different stress paths through laboratory tests and numerical simulations.The results indicate that the shear strength depends on the stress path and a decrease in the shear surface integrity reduces the degree of dependence.The cohesion and friction angle of the Mohr‒Coulomb criterion decrease with weakening of the shear surface integrity.For different stress paths,the direct shear strength is always greater than that of other shear stress paths.The pattern of changes in the acoustic emission count and cumulative count indirectly reflectsthe above findings.Numerical simulations further indicate that the different principal stress states and normal suppression effects during the shearing process lead to changes in the factors of crack propagation,resulting in different mechanical behaviours under various stress paths.For rocks with different integrity levels,the main reason for the different path dependences of shear strength is that the size of the area affected by shear is different.Shear failure will concentrate on the shear plane when the normal inhibition effect is greater.This study explores the mechanism of rock shear behaviour,providing a theoretical basis for establishing more accurate constitutive models and strength criteria.展开更多
Characteristic stresses are critical indicators for microcrack initiation and propagation in rock,a process intrinsically linked to fracture mode.To investigate fracture mode evolution and its feasibility for estimati...Characteristic stresses are critical indicators for microcrack initiation and propagation in rock,a process intrinsically linked to fracture mode.To investigate fracture mode evolution and its feasibility for estimating characteristic stresses,this study conducted uniaxial compression and cyclic loading-unloading tests on fine-and coarse-grained granite with acoustic emission(AE) monitoring.Cyclic target stresses were set within intervals determined by characteristic stresses.Analysis using the AE parameters AFRA revealed that fracture mode evolution correlates with damage level,and shear microcrack propagation primarily governs macroscopic failure.A characteristic stress estimation method was developed by mapping key points on the shear crack proportion curve: crack closure stress(transition between fluctuating and stable segments),crack initiation stress(inflection point of curve rise),and crack damage stress(slope change point in ascending segment).Comparative analysis with the crack volumetric strain method validated the proposed method.The influences of fracture mode dividing line and statistical interval were discussed,with practical recommendations provided.Compared to conventional AE parameters,the fracture mode proportion exhibits lower sensitivity to AE parameter variations,enabling more reliable identification of characteristic stress points.Furthermore,it directly reflects microcrack evolution behavior,enhancing interpretability and providing a novel perspective for AE-based characteristic stress determination.展开更多
Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence condition...Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.展开更多
Thick-hard roof instability is a major source of dynamic pressure hazards in underground coal mining.This study investigated the instability mechanism and control of thick-hard roof caving at the 1014 mining face of Y...Thick-hard roof instability is a major source of dynamic pressure hazards in underground coal mining.This study investigated the instability mechanism and control of thick-hard roof caving at the 1014 mining face of Yushuquan Coal Mine,Xinjiang,China.A physical similarity model was established to simulate mining-induced roof failure,and overburden deformation,mining-induced stress,and acoustic emission(AE)activity were monitored throughout excavation.The results showed that roof caving developed as a discontinuous dynamic instability process characterized by local initiation,upward fracture propagation,sudden large-scale collapse,and subsequent re-stabilization.As the mining face advanced,an arch-shaped stress concentration shell formed above the goaf and evolved with overburden load redistribution.The formation,migration,dissipation,and reconstruction of this shell controlled periodic roof caving and stress mutation.Before roof collapse,AE events increased markedly along the caving boundary,indicating progressive microcrack coalescence.Collapse was accompanied by an abrupt stress drop and a sharp increase in AE activity,suggesting rapid energy release and providing potential precursor information for roof instability.Based on this mechanism,a three-stage blasting strategy was proposed,including directional presplitting,fan-shaped loosening blasting,and deep-hole weakening.Field application showed that the caving block size decreased by more than 50%,the suspended roof distance decreased from 16 m to 9 m,roof subsidence and coal seam deformation decreased by 40.2% and 51.7%,respectively,and hydraulic support peak pressure decreased by 8.0%-8.8%.These findings indicate that the proposed method can regulate stress transfer,promote controlled roof caving,and improve thick-hard roof stability under the studied geological conditions.展开更多
Prohibitin(PHB)plays critical roles in plant growth and development.In this study,we utilized CRISPR/Cas9 gene-editing technology to generate homozygous OsPHB2 knockout transgenic plants,designated cr-osphb2.The cr-os...Prohibitin(PHB)plays critical roles in plant growth and development.In this study,we utilized CRISPR/Cas9 gene-editing technology to generate homozygous OsPHB2 knockout transgenic plants,designated cr-osphb2.The cr-osphb2 line exhibited wider leaves,dwarfism,and shorter panicles.Subcellular localization results indicated that OsPHB2 localizes to mitochondria.Under salt stress conditions,cr-osphb2 exhibited enhanced tolerance.Haplotype(Hap)analysis identified three major Haps(Hap1,Hap2,and Hap3)of OsPHB2,among which Hap2 was associated with a greater number of effective panicles and higher yield,indicating its potential value for breeding applications.Collectively,our findings demonstrate that OsPHB2 plays an important role in regulating growth,development,and salt stress responses in rice.展开更多
Low temperature is a major abiotic stress factor inducing the accumulation of dehydrins in plants.Dehydrins are hydrophilic,heat-stable proteins implicated in plant stress responses;however,their synthesis under cold ...Low temperature is a major abiotic stress factor inducing the accumulation of dehydrins in plants.Dehydrins are hydrophilic,heat-stable proteins implicated in plant stress responses;however,their synthesis under cold conditions during the early stages of wheat development has not been sufficiently studied.This study investigated the relationship between cold-induced dehydrin accumulation in etiolated seedlings and frost tolerance in wheat cultivars differing in their level of frost tolerance.Three-day-old seedlings of high frost-tolerant(high-FT)cultivars(Antonivka,Doskonala,and Nordika)and low frost-tolerant(low-FT)cultivars(Tobak,Tonnage,and Altigo)of Triticum aestivum L.were hardened at+3℃ for six days.Dehydrin accumulation was analyzed by electrophoretic separation,while frost tolerance was assessed based on seedling survival following freezing at−4,−9,and−12℃.Cold-induced oxidative damage was evaluated by determining malondialdehyde(MDA)content in seedling shoots after freezing at−4℃.In control seedlings,dehydrins were barely detectable in all cultivars.Cold hardening at+3℃ induced pronounced accumulation of dehydrins with molecular masses of approximately 46,49.6,and 68 kDa in both high-FT and low-FT cultivars.In contrast,low-molecular-weight dehydrins(14–16 kDa)were detected predominantly in high-FT cultivars.Seedling survival after freezing at−12℃ showed a strong positive correlation with total dehydrin content(r=0.82).Even stronger correlations were observed between the content of low-molecular-weight dehydrins(14–16 kDa)and seedling survival after freezing at−9 and−12℃(r=0.84 and 0.94,respectively).An inverse correlation was found between 14–16 kDa dehydrin content and MDA accumulation following freezing at−4℃(r=−0.87).These results indicate that low-molecular-weight dehydrins play an important role in protecting etiolated wheat seedlings from cold-induced oxidative stress and may serve as reliable biochemical markers of frost tolerance.展开更多
We investigated the influence of historical earthquakes on the 2022 Luding MS6.8 earthquake and its subsequent effects.We computed the viscoelastic Coulomb stress changes induced by these historical seismic events ...We investigated the influence of historical earthquakes on the 2022 Luding MS6.8 earthquake and its subsequent effects.We computed the viscoelastic Coulomb stress changes induced by these historical seismic events using the rupture model of historical earthquakes and the layered Maxwell viscoelastic medium model.Our findings indicate that the Luding earthquake was brought forward approximately 29 years because of several historical earthquakes.Specifically,the 1923 Renda MS7.3 earthquake,the 1933 Diexi MS7.5 earthquake,the 1973 Luhuo MS7.3 earthquake,the 2008 Kangding MS5.1 earthquake,the 2008 Wenchuan MS8.0 earthquake,the 2014 Kangding MS6.3 earthquake,and the 2014 Kangding MS5.8 earthquake advanced the occurrence of the event by 117.61,26.67,84.51,0.27,0.91,7.64,and 3.17 years,respectively.Conversely,the 1936 Mabian earthquake swarm,the 1948 Litang MS7.3 earthquake,the 1955 Kangding MS7.5 earthquake,and the 2013 Lushan MS7.0 earthquake delayed its occurrence by 39.89,22.43,144.23,and 4.89 years,respectively.Furthermore,by employing the halfspace homogeneous elastic model and the rupture characteristics of the Luding earthquake,we computed the coseismic Coulomb stress changes in neighboring faults.Our results reveal increased Coulomb stress on the Xianshuihe fault(excluding its southern segment),the Anninghe fault,the Zemuhe fault,the Daliangshan fault,the southern segment of the Longmenshan fault,the northern segment of the Mabian-Yanjin fault,and the Xiaojinhe fault.Conversely,we observed stress decreases in the southern segment of the Jinshajiang fault,the central and eastern segments of the Longriba fault,the Mabian-Yanjin fault(excluding its northern segment),and the southern segment of the Xianshuihe fault.展开更多
基金supported by the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project (2024ZD1000703)National Natural Science Foundation of China (Grant Nos. 42274138, U23A2029, 41874116)
摘要On 28 March 2025,a strong Mw 7.7 earthquake struck the seismic gap in the central section of the Sagaing Fault in Myanmar,causing significant damages and casualties in Myanmar and neighboring countries.Major earthquakes like this are expected to transfer stresses to nearby active regions and change their seismic hazards in the near future.In this study,based on a stratified viscoelastic model and a coseismic slip model,we calculated the co-and post-seismic Coulomb stress change(△CFS)imparted by the Mw 7.7 Myanmar earthquake to the main active faults in the adjacent southwestern Yunnan region in China.Our results show that five fault segments experience up to 3 kPa of coseismic stress increase,including the Longling-Lancang Fault,the Nantinghe Fault,the Menglian Fault,the Heihe Fault,and the Red River Fault,respectively.The pattern of postseismic △CFS is similar to that of coseismic △CFS,suggesting that with the increasing elapsed time,the stress level continues to increase in these fault zones.The coseismic auxiliary stress fields show that the orientation of the principal tensile stress is predominantly NE-SW in the northern part of the southwestern Yunnan region,and shows clockwise rotation to NW-SE in the south.This stress regime controls the additional slip motion,consistent with that reflected by the coseismic shear stress change.Combined with other geophysical and geodetic data,we propose that more attention should be paid to the Longling-Lancang Fault,the Nantinghe Fault,the Menglian Fault,and the Heihe Fault,potential candidates for the next strong earthquakes in this region.
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2024ZD1700201)the National Natural Science Foundation of China(Nos.U2034206,51974014 and 51574014)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2024A1515011631)the National Key Research and Development Project of China(No.2022YFC3004601)。
摘要In-situ stress is a key parameter for underground mine design and rock stability analysis.The borehole overcoring technique is widely used for in-situ stress measurement,but the rheological recovery deformation of rocks after stress relief introduces errors.To improve accuracy,this study proposes an in-situ stress solution theory that incorporates time-dependent stress relief effects.Triaxial stepwise loadingunloading rheological tests on granite and siltstone established quantitative relationships between instantaneous elastic recovery and viscoelastic recovery under different stress levels,confirming their impact on measurement accuracy.By integrating a dual-class elastic deformation recovery model,an improved in-situ stress solution theory was derived.Additionally,accounting for the nonlinear characteristics of rock masses,a determination method for time-dependent nonlinear mechanical parameters was proposed.Based on the CSIRO hollow inclusion strain cell,time-dependent strain correction equations and long-term confining pressure calibration equations were formulated.Finally,the proposed theory was successfully applied at one iron mine(736 m depth)in Xinjiang,China,and one coal mine(510 m depth)in Ningxia,China.Compared to classical theory,the calculated mean stress values showed accuracy improvements of 6.0%and 9.4%,respectively,validating the applicability and reliability of the proposed theory.
基金The synchrotron radiation experiments were performed at SPring-8 under Proposal Nos.2024A1732(BL19B2)and 2025A3684(BL14B1)The authors gratefully acknowledge the valuable support from these facilities and the assistance of the beamline scientists at SPring-8.
摘要The structural integrity of multi-pass welded austenitic stainless steel pipes is significantly influenced by the synergistic effect of multi-scale residual stresses.Macroscopic(TypeⅠ)stresses drive distortion and stress corrosion cracking(SCC),while microscopic(TypeⅡ)stresses,arising from intergranular incompatibility,control micro-damage initiation.However,due to limitations of traditional techniques,such as lack of microscopic resolution or difficulty in handling large components,the spatial distribution of stresses within the complex heat-affected zone(HAZ)remains difficult to obtain experimentally.This study applies synchrotron radiation-based Double Exposure Method(DEM)to directly measure and decouple TypeⅠand TypeⅡresidual stress fields in multi-pass welded SUS316 steel pipe.High-resolution spatial distribution maps of the two decoupled stress types in the HAZ are presented.The results reveal a highly heterogeneous and complementary distribution:TypeⅠstress exhibits a typical macroscopic gradient,while TypeⅡstress shows strong local variations at the grain scale,especially in the microstructure transition region near the fusion boundary.The results further show that the initiation of SCC is governed by local TypeⅡstresses,whereas subsequent crack propagation is driven by far-field TypeⅠstresses.This experimental insight into the decoupled multi-scale stress state provides a direct pathway for accurately assessing weld integrity and clarifying the drivers of SCC in critical industrial components such as nuclear power plants.
基金The National Natural Science Foundation of China(12202294)the Sichuan Science and Technology Program(2024NSFSC1346)are acknowledged.
摘要FeMnSi-based shape memory alloys(SMAs)have great applied potential to large-scale structures in civil engineering,especially as an aseismic structural material.Low-cycle fatigue performance is one of the most important properties of FeMnSi-based SMA aseismic materials.However,the low-cycle fatigue behavior of such SMAs,especially the stress-controlled low-cycle fatigue behavior(with ratchetting effect),has not been clearly understood.In this work,the low-cycle fatigue behavior of the FeMnSiCrNi SMAs subjected to stress-controlled cyclic tension–compression loads is investigated,and the effects of temperature,loading frequency,stress amplitude,and stress ratio are addressed.By analyzing the cyclic stress–strain response,fatigue fracture surface morphology,dissipation energy,ratchetting strain,and equivalent damping ratio,the mechanisms behind the temperature-,loading frequency-,stress amplitude-,and stress ratio-dependent low-cycle fatigue behavior are discussed.The results show that the plasticity,martensitic transformation,and/or the ratchetting strain caused by their tension–compression asymmetry are the decisive factors affecting the low-cycle fatigue behavior of FeMnSiCrNi SMAs.
基金Supported by National Natural Science Foundation of China(Grant Nos.52475285,52305162)Fujian Provincial Natural Science Foundation of China(Grant No.2025J09012)Fundamental Research Funds for the Central Universities of China(Grant Nos.20720240062,20720240033)。
摘要The dual alloy turbine disk can fully leverage the advantages of dissimilar materials and has broad application prospects.Multi-material topology optimization(MMTO)provides possibilities for its innovative design.However,the coupling between multi-material design variables and centrifugal loads poses challenges,in-cluding insufficient stress prediction accuracy,ineffective stress control,and difficulties in optimization con-vergence.Therefore,a new MMTO method that considers accurate stress prediction and control under cen-trifugal loads is proposed herein.The core ideas are as follows.(1)Introducing the multi-material predicted density to reduce the number of gray elements,proposing a multi-material transition factor for flexible se-lection of stiffness matrix interpolation,and thus developing an innovative accurate multi-material stress prediction method.(2)By modifying the normalized global stress method and utilizing a fixed step size to update the multi-material global stress relaxation coefficient,the maximum stress of the design domain is effectively controlled.(3)Deriving the stress sensitivity of axisymmetric problems under the complex coupling of cen-trifugal loads and multi-material design variables to improve the optimization convergence of stresses.Then MMTO for a turbine disk is conducted using two popular alloys(GH4169 and K418B).The results show that the proposed MMTO method effectively controls maximum stress,fully utilizes the advantages of both alloys and achieves a novel dual-alloy turbine disk structure.
基金supported by the Natural Science Foundation of Shaanxi Province(Key Program),No.2021JZ-60(to HZ)。
摘要The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins.However,if the unfolded protein response fails to restore endoplasmic reticulum homeostasis,it can trigger proinflammatory and pro-death signals,which are implicated in various malignancies and are currently being investigated for their role in retinal degenerative diseases.This paper reviews the role of the unfolded protein responsein addressing endoplasmic reticulumstress in retinal degenerative diseases.The accumulation of ubiquitylated misfolded proteins can lead to rapid destabilization of the proteome and cellular demise.Targeting endoplasmic reticulum stress to alleviate retinal pathologies involves multiple strategies,including the use of chemical chaperones such as 4-phenylbutyric acid and tauroursodeoxycholic acid,which enhance protein folding and reduce endoplasmic reticulum stress.Small molecule modulators that influence endoplasmic reticulum stress sensors,including those that increase the expression of the endoplasmic reticulum stress regulator X-box binding protein 1,are also potential therapeutic agents.Additionally,inhibitors of the RNAse activity of inositol-requiring transmembrane kinase/endoribonuclease 1,a key endoplasmic reticulum stress sensor,represent another class of drugs that could prevent the formation of toxic aggregates.The activation of nuclear receptors,such as PPAR and FXR,may also help mitigate ER stress.Furthermore,enhancing proteolysis through the induction of autophagy or the inhibition of deubiquitinating enzymes can assist in clearing misfolded proteins.Combination treatments that involve endoplasmicreticulum-stress-targeting drugs and gene therapies are also being explored.Despite these potential therapeutic strategies,significant challenges remain in targeting endoplasmic reticulum stress for the treatment of retinal degeneration,and further research is essential to elucidate the mechanisms underlying human retinal diseases and to develop effective,well-tolerated drugs.The use of existing drugs that target inositol-requiring transmembrane kinase/endoribonuclease 1 and X-box binding protein 1 has been associated with adverse side effects,which have hindered their clinical translation.Moreover,signaling pathways downstream of endoplasmic reticulum stress sensors can contribute to therapy resistance.Addressing these limitations is crucial for developing drugs that can be effectively used in treating retinal dystrophies.In conclusion,while the unfolded protein response is a promising therapeutic target in retinal degenerative diseases,additional research and development efforts are imperative to overcome the current limitations and improve patient outcomes.
基金financially supported by the National Science and Technology Major Project of China(No.2019-VII-0019-0161 and No.2019-VII-0004-0144)the National Natural Science Foundation of China(No.92360302)the Shandong Provincial Natural Science Foundation of China(No.ZR2021QE103)。
摘要Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.
基金support provided by the Key Research and Development Program of Hubei Province of China(2021BCA150)the National Natural Science Foundation of China(52078231).
摘要The use of fiber-reinforced polymer(FRP)jackets or tubes as confining devices can significantly improve the compressive performance of ultra-high-performance concrete(UHPC).For FRP-confined UHPC,an analysis-oriented stress–strain model is essential for a comprehensive understanding of its compressive behavior and the development of design models.Although several analysis-oriented stress–strain models have been developed for FRP-confined normal-strength concrete(NSC),such models for FRP-confined UHPC are still lacking.In this study,an experiment is conducted to investigate the failure mechanism of UHPC confined with FRP under concentric compression,and the stress–strain behavior of the FRP-confined UHPC is analyzed using the stress–strain models of actively-confined UHPC.Results showed that the stress-path-independency assumption,which has been proven to apply to FRP-confined NSC,was inapplicable to FRP-confined UHPC.By modifying the confining pressure to consider the influence of stress-path dependency,an analysis-oriented model was proposed.The proposed model was verified using a collected test database.The results show that the proposed model accurately predicted the stress–strain behavior of FRP-confined UHPC.
摘要Background:Post-traumatic stress disorder(PTSD)is a complicated neuropsychiatric disorder that is marked by long-term neuroinflammation,oxidative stress,and poor neuroplasticity in stress-sensitive brain areas.Hesperidin is a citrus-derived flavanone glycoside that has been reported to have multitarget neuroprotective effects with antioxidant,anti-inflammatory,and neurotrophic regulatory activities.However,its integrated effects across convergent pathological pathways in validated PTSD models remain insufficiently defined.Methods:Male Wistar rats were subjected to the single prolonged stress(SPS)paradigm and treated with hesperidin(50,100,and 200 mg/kg),fluoxetine(20 mg/kg),or vehicle for 14 days.Biochemical assessments(malondialdehyde[MDA],catalase[CAT],superoxide dismutase[SOD])and immunohistochemical measurements of neuronal and glial integrity(Neu N,glial fibrillary acidic protein[GFAP],brain-derived neurotrophic factor[BDNF])in the hippocampus,amygdala,and prefrontal cortex were performed.Results:SPS exposure induced marked oxidative imbalance,evidenced by increased MDA levels and reduced CAT activity,alongside significant upregulation of tumor necrosis factorα(TNF-α),interleukin 6(IL-6),and IL-1β,increased astrocytic reactivity(GFAP),and reduced BDNF expression.Hesperidin treatment significantly attenuated lipid peroxidation,partially restored CAT activity,and suppressed pro-inflammatory cytokines,with the most pronounced effect observed for IL-1β.Notably,hesperidin reduced astrocytic activation and preserved neuronal morphology,while enhancing BDNF expression in a dose-dependent manner,with optimal effects at 50–100 mg/kg.Conversely,there was little group variation in the activity of SOD,implying pathwayselective redox regulation.Conclusion:Hesperidin has multipathway,coordinated,modulatory effects on oxidative stress,neuroinflammation,glial activation,and neurotrophic signaling in the SPS model of PTSD.These findings support its utility as a mechanistic probe for interrogating convergent stress-related neuropathological pathways.
摘要Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.
基金Project(52464010)supported by the National Natural Science Foundation of ChinaProject(LDLFJSFW2024-9)supported by the Guizhou Provincial Social Funding Projects,China。
摘要Due to the unique geological structure in the Guizhou region,issues such as stress concentration and inefficient resource utilization efficiency arise during repeated mining of close-distance coal seam.This study focuses on the Longfeng Coal Mine in Guizhou,investigating the evolution of stress arches and abutment pressure distribution under repeated mining conditions through similarity simulations,numerical simulations,and theoretical analysis.The study introduces a novel composite stress arch model,which more accurately represents stress evolution under complex mining conditions compared to traditional single arch theories.The model highlights the gradual transformation of a single stress arch into a composite structure,accounting for the increasing complexity of the stress distribution.Based on these evolution characteristics,a mechanical model of composite arches under nonlinear loading was developed.The calculation results and field monitoring data show that after repeated mining,the stop-mining coal pillar width should be optimized between 65 and 70 m.The research reveals the coupling relationship between the evolution of composite arches and the distribution of abutment pressure,which aids in optimizing coal pillar design,enhancing resource recovery rates,and ensuring the stability of roadways and stopes.
基金financially supported by the State Key Research Development Programme of China(2024YFC3013803)the National Natural Science Foundation of China(U24B2045)the Fundamental Research Funds for the Central Universities(FRFAT-25-012).
摘要The growing burial depth increases the potential risk of ground stress-induced coal and rock dynamic disasters in coal mining.This study attempts to use microseismic and computed tomography(MS-CT)to quantitatively characterize the stress field in coal seam areas.A comprehensive approach encompassing laboratory experiments,numerical simulations,and field investigations was employed to accomplish this objective.The experimental findings suggest a power function relationship between the wave velocity of coal and stress.The model relating wave velocity ratio to stress proves more suitable for research on stress field quantification.This model captures the positive correlation between wave velocity and stress changes and eliminates the influence of sample differences through normalization,rendering the fitting parameter b applicable in the field.This paper takes the No.22 coal seam of Jinjia coal mine as the research object;MS-CT technology was used to generate the cloud map of wave velocity field distribution in the 11224 working face and combined with the experimentally established relational model to relate the wave velocity ratio to the stress and calculate the results of quantitative characterization of the regional stress.At the same time,a detailed three-dimensional numerical model was established and simulated to obtain the stress distribution in the 11224 working face area.Comparison of the simulated stress field results with the quantitative results of MS-CT shows that the general trend is basically the same,and the stress is higher in the area with greater burial depth.The area affected by the overlying goaf has lower stress in the coal seam.The maximum error value of the two is within±2 MPa,and the correlation coefficient is 0.79,indicating a strong correlation.Therefore,the MS-CT technique combined with the experimental wave velocity-stress coupling relationship model can determine the stress field distribution and realize the quantitative stress characterization.This provides a crucial foundation for analyzing the mechanical model of coal seam instability and calculating the judgment index of coal-rock dynamic disaster excitation.
基金supported by Shandong Provincial Natural Science Foundation(ZR2023QC016)Doctoral Research Initiation Foundation of Liaocheng University(318052288)+2 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(XDA28110100)National Key Research and Development Program of China(2022YFD1500505)the Natural Science Foundation of China(32370321).
摘要Strigolactones (SLs) are a group of phytohormones that enhance hyphal branching of arbuscular mycorrhizal fungi (AMF), promote seed germination of parasitic plants, and influence plant growth, development, and stress acclimation. SLs improve plant stress resilience by modulating shoot and root architecture, photosynthesis, nutrient homeostasis, and antioxidant defense. Under nutrient deficiency, SL accumulation enhances AMF colonization and triggers the expression of genes related to the nutrient starvation response. When subjected to drought, SLs mitigate water loss by modulating stomatal density and closure, cell membrane integrity, and anthocyanin biosynthesis. SLs also mitigate salinity and heavy metal stresses by maintaining ion homeostasis, while conferring thermotolerance and enhancing chilling tolerance. In this review, we highlight recent advances in SLs and their mechanisms in plant responses to environmental stresses, including nutrient deficiencies, drought, salinity, extreme temperatures, metal toxicity, herbivore attack, and pathogen infection. We further discuss how SLs interact with other phytohormones to coordinate the physiological, biochemical, and molecular regulatory events critical for plant acclimation to abiotic and biotic stresses.
基金support from the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX24_2822)the Graduate Innovation Program of China University of Mining and Technology(Grant No.2024WLKXJ205)the National Natural Science Foundation of China(Grant No.52474157).
摘要Excavation causes stress redistribution and affects the stress path during the shearing process of rock.The shear strength of rock varies under different stress paths,and the presence of defects reduces the shear strength.To further investigate this phenomenon,this study investigates the shear behaviour of rocks with different shear surface integrities under the influenceof different stress paths through laboratory tests and numerical simulations.The results indicate that the shear strength depends on the stress path and a decrease in the shear surface integrity reduces the degree of dependence.The cohesion and friction angle of the Mohr‒Coulomb criterion decrease with weakening of the shear surface integrity.For different stress paths,the direct shear strength is always greater than that of other shear stress paths.The pattern of changes in the acoustic emission count and cumulative count indirectly reflectsthe above findings.Numerical simulations further indicate that the different principal stress states and normal suppression effects during the shearing process lead to changes in the factors of crack propagation,resulting in different mechanical behaviours under various stress paths.For rocks with different integrity levels,the main reason for the different path dependences of shear strength is that the size of the area affected by shear is different.Shear failure will concentrate on the shear plane when the normal inhibition effect is greater.This study explores the mechanism of rock shear behaviour,providing a theoretical basis for establishing more accurate constitutive models and strength criteria.
基金financial support from the National Natural Science Foundation of China (Nos.52434006,51927808,and 52374151)Fundamental Research Funds for the Central Universities of Central South University (No.2024zzts0420)。
摘要Characteristic stresses are critical indicators for microcrack initiation and propagation in rock,a process intrinsically linked to fracture mode.To investigate fracture mode evolution and its feasibility for estimating characteristic stresses,this study conducted uniaxial compression and cyclic loading-unloading tests on fine-and coarse-grained granite with acoustic emission(AE) monitoring.Cyclic target stresses were set within intervals determined by characteristic stresses.Analysis using the AE parameters AFRA revealed that fracture mode evolution correlates with damage level,and shear microcrack propagation primarily governs macroscopic failure.A characteristic stress estimation method was developed by mapping key points on the shear crack proportion curve: crack closure stress(transition between fluctuating and stable segments),crack initiation stress(inflection point of curve rise),and crack damage stress(slope change point in ascending segment).Comparative analysis with the crack volumetric strain method validated the proposed method.The influences of fracture mode dividing line and statistical interval were discussed,with practical recommendations provided.Compared to conventional AE parameters,the fracture mode proportion exhibits lower sensitivity to AE parameter variations,enabling more reliable identification of characteristic stress points.Furthermore,it directly reflects microcrack evolution behavior,enhancing interpretability and providing a novel perspective for AE-based characteristic stress determination.
基金supported by the National Natural Science Foundation of China(Grant Nos.32160501 and 32201901)the Accelerated Breeding Initiative of the Consultative Group on International Agricultural Research(Grant No.INIT-01)+2 种基金the Natural Science Foundation of Guangxi,China(Grant No.2021GXNSFAA220026)the Program on National Modern Agricultural Technology System Guangxi Innovation Team,China(Grant No.nycytxgxcxtd-2021-01-04)the Advantage Team Project of Guangxi Academy of Agricultural Sciences,China(Grant No.2026YT070).
摘要Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.
基金funded by the National Natural Science Foundation of China(Grant number U24A2085)。
摘要Thick-hard roof instability is a major source of dynamic pressure hazards in underground coal mining.This study investigated the instability mechanism and control of thick-hard roof caving at the 1014 mining face of Yushuquan Coal Mine,Xinjiang,China.A physical similarity model was established to simulate mining-induced roof failure,and overburden deformation,mining-induced stress,and acoustic emission(AE)activity were monitored throughout excavation.The results showed that roof caving developed as a discontinuous dynamic instability process characterized by local initiation,upward fracture propagation,sudden large-scale collapse,and subsequent re-stabilization.As the mining face advanced,an arch-shaped stress concentration shell formed above the goaf and evolved with overburden load redistribution.The formation,migration,dissipation,and reconstruction of this shell controlled periodic roof caving and stress mutation.Before roof collapse,AE events increased markedly along the caving boundary,indicating progressive microcrack coalescence.Collapse was accompanied by an abrupt stress drop and a sharp increase in AE activity,suggesting rapid energy release and providing potential precursor information for roof instability.Based on this mechanism,a three-stage blasting strategy was proposed,including directional presplitting,fan-shaped loosening blasting,and deep-hole weakening.Field application showed that the caving block size decreased by more than 50%,the suspended roof distance decreased from 16 m to 9 m,roof subsidence and coal seam deformation decreased by 40.2% and 51.7%,respectively,and hydraulic support peak pressure decreased by 8.0%-8.8%.These findings indicate that the proposed method can regulate stress transfer,promote controlled roof caving,and improve thick-hard roof stability under the studied geological conditions.
基金supported by the Zhejiang Provincial Natural Science Outstanding Youth Fund Continuation Project,China(Grant No.LRG25C130002)the Innovation Program of the Chinese Academy of Agricultural Sciences(Grant No.CAAS-CSCB-202402)+3 种基金the Zhejiang Provincial Natural Science Foundation,China(Grant No.LD24C130001)the Biological Breeding-National Science and Technology Major Projects of China(Grant No.2023ZD04066)the Central Public-Interest Scientific Institution Basal Research Fund,China(Grant No.Y2025YC96)the Agricultural Science and Technology Innovation Program,China(Grant No.CAAS-ASTIP-2021-CNRRI).
摘要Prohibitin(PHB)plays critical roles in plant growth and development.In this study,we utilized CRISPR/Cas9 gene-editing technology to generate homozygous OsPHB2 knockout transgenic plants,designated cr-osphb2.The cr-osphb2 line exhibited wider leaves,dwarfism,and shorter panicles.Subcellular localization results indicated that OsPHB2 localizes to mitochondria.Under salt stress conditions,cr-osphb2 exhibited enhanced tolerance.Haplotype(Hap)analysis identified three major Haps(Hap1,Hap2,and Hap3)of OsPHB2,among which Hap2 was associated with a greater number of effective panicles and higher yield,indicating its potential value for breeding applications.Collectively,our findings demonstrate that OsPHB2 plays an important role in regulating growth,development,and salt stress responses in rice.
基金the project“Comprehensive scientific study of mechanisms of resistance of crop plants to biotic,abiotic,and anthropogenic stress,use of genetic diversity,and creation of stress-resistant cultivars and hybrids”,funded by the Ministry of Education and Science of Ukraine(registration number 0125U003530)supported by the Ministry of Agriculture of the Czech Republic,Grant number QL26010208.
摘要Low temperature is a major abiotic stress factor inducing the accumulation of dehydrins in plants.Dehydrins are hydrophilic,heat-stable proteins implicated in plant stress responses;however,their synthesis under cold conditions during the early stages of wheat development has not been sufficiently studied.This study investigated the relationship between cold-induced dehydrin accumulation in etiolated seedlings and frost tolerance in wheat cultivars differing in their level of frost tolerance.Three-day-old seedlings of high frost-tolerant(high-FT)cultivars(Antonivka,Doskonala,and Nordika)and low frost-tolerant(low-FT)cultivars(Tobak,Tonnage,and Altigo)of Triticum aestivum L.were hardened at+3℃ for six days.Dehydrin accumulation was analyzed by electrophoretic separation,while frost tolerance was assessed based on seedling survival following freezing at−4,−9,and−12℃.Cold-induced oxidative damage was evaluated by determining malondialdehyde(MDA)content in seedling shoots after freezing at−4℃.In control seedlings,dehydrins were barely detectable in all cultivars.Cold hardening at+3℃ induced pronounced accumulation of dehydrins with molecular masses of approximately 46,49.6,and 68 kDa in both high-FT and low-FT cultivars.In contrast,low-molecular-weight dehydrins(14–16 kDa)were detected predominantly in high-FT cultivars.Seedling survival after freezing at−12℃ showed a strong positive correlation with total dehydrin content(r=0.82).Even stronger correlations were observed between the content of low-molecular-weight dehydrins(14–16 kDa)and seedling survival after freezing at−9 and−12℃(r=0.84 and 0.94,respectively).An inverse correlation was found between 14–16 kDa dehydrin content and MDA accumulation following freezing at−4℃(r=−0.87).These results indicate that low-molecular-weight dehydrins play an important role in protecting etiolated wheat seedlings from cold-induced oxidative stress and may serve as reliable biochemical markers of frost tolerance.
基金supported by the National Natural Science Foundation of China(Nos.42174074,and 41674055).
摘要We investigated the influence of historical earthquakes on the 2022 Luding MS6.8 earthquake and its subsequent effects.We computed the viscoelastic Coulomb stress changes induced by these historical seismic events using the rupture model of historical earthquakes and the layered Maxwell viscoelastic medium model.Our findings indicate that the Luding earthquake was brought forward approximately 29 years because of several historical earthquakes.Specifically,the 1923 Renda MS7.3 earthquake,the 1933 Diexi MS7.5 earthquake,the 1973 Luhuo MS7.3 earthquake,the 2008 Kangding MS5.1 earthquake,the 2008 Wenchuan MS8.0 earthquake,the 2014 Kangding MS6.3 earthquake,and the 2014 Kangding MS5.8 earthquake advanced the occurrence of the event by 117.61,26.67,84.51,0.27,0.91,7.64,and 3.17 years,respectively.Conversely,the 1936 Mabian earthquake swarm,the 1948 Litang MS7.3 earthquake,the 1955 Kangding MS7.5 earthquake,and the 2013 Lushan MS7.0 earthquake delayed its occurrence by 39.89,22.43,144.23,and 4.89 years,respectively.Furthermore,by employing the halfspace homogeneous elastic model and the rupture characteristics of the Luding earthquake,we computed the coseismic Coulomb stress changes in neighboring faults.Our results reveal increased Coulomb stress on the Xianshuihe fault(excluding its southern segment),the Anninghe fault,the Zemuhe fault,the Daliangshan fault,the southern segment of the Longmenshan fault,the northern segment of the Mabian-Yanjin fault,and the Xiaojinhe fault.Conversely,we observed stress decreases in the southern segment of the Jinshajiang fault,the central and eastern segments of the Longriba fault,the Mabian-Yanjin fault(excluding its northern segment),and the southern segment of the Xianshuihe fault.