期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到19篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Emerging approaches to probing ion channel structure and function 认领 引用 被引量：1
1
作者 Wei-Guang Li Tian-Le Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2012年第4期351-374,共24页
Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into ... Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity. 展开更多
关键词 ion channel structure and function mutagenesis covalent modification voltage-clamp fluorometry computational chemistry
暂未订购 下载PDF
Effects of Aluminum Trichloride on Structure and Function of Kidney in Chickens 认领 引用
2
作者 Zhang Ji-hong Luo Ji-long +4 位作者 Yu Hong-xiang Bai Chong-sheng Han Yan-fei Xia Shi-liang Li Yan-fei 《Journal of Northeast Agricultural University(English Edition)》 CAS 2012年第3期83-86,共4页
To investigate the effects of aluminum trichloride （AlCl3） on renal structure and function in chickens, the chickens were injected continuously with different gradient AlCl3 for 60 days to establish sub-chronic alum... To investigate the effects of aluminum trichloride （AlCl3） on renal structure and function in chickens, the chickens were injected continuously with different gradient AlCl3 for 60 days to establish sub-chronic aluminum （Al） intoxication model. The AI concentration in serum and kidney, contents of creatinine （Cr） and blood urea nitrogen （BUN） in serum were detected, and the renal structure was also observed by optical microscope. The results showed that the A1 concentration in serum and kidney, the contents of Cr and BUN in serum were significantly higher in Al-treated chickens than those in the control group （P〈0.05; P〈0.01） and there was an AlCl3 dose-depended manner. Histopathologically, in the low dose group, acinus renis swelled mildly and there were no apparent pathological changes in nephric tubule and proximal convoluted tubule. In the middle and high dose group, acinus renis swelled, glomerular cells increased, nephric tubule cloudy swelled, and epithelial cells of proximal convoluted tubule swelled. The results indicated that sub-chronic Al exposure impaired the renal structure and function in chickens. 展开更多
关键词 aluminum trichloride structure and function kidney chicken
暂未订购 下载PDF
Mechanical Properties of Living Adherent Cells :Relationship with Structure and Function 认领 引用
3
作者 R. FODIL S. Féréol +3 位作者 E. PLANUS V.M. LAURENT B. LOUIS D. ISABEY 《生物医学工程学杂志》 EI CAS 北大核心 2005年第S1期9-10,共2页
关键词 Relationship with Structure and Function Mechanical Properties of Living Adherent Cells PBM cell
暂未订购 下载PDF
Effects of Gd on Microstructure and Mechanical Properties of Duplex Stainless Steels for Neutron Absorbing 认领 引用
4
作者 Jia Dongxiao Zhao Pengfei +3 位作者 Liang Tian Hou Kunlei Jiang Yuefeng Ma Yingche 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2026年第7期1632-1640,共9页
The effects of different Gd contents on microstructure and mechanical properties of 00Cr23Ni8Mo1.4Mn1.4Si0.5alloy were researched.Results indicate that element Gd exists mainly in three forms in the alloy:Gd2O3,... The effects of different Gd contents on microstructure and mechanical properties of 00Cr23Ni8Mo1.4Mn1.4Si0.5alloy were researched.Results indicate that element Gd exists mainly in three forms in the alloy:Gd2O3,M12Gd,and M3Gd phases(M=Fe,Cr,Ni).With the increase in Gd content,the contents of Gd-containing precipitate and ferrite phase are increased,whereas the austenite phase content is decreased.The Gd oxide and precipitation of two Gd-containing phases are the main causes of cracking in the alloy during the hot deformation process.The partially aggregated Gd oxide particles and the difficult-to-deform Gd-containing precipitates on the grain boundary jointly decrease the hot ductility of the alloy.With the increase in amount of Gd addition,the tensile strength and section shrinkage ratio of the alloy are decreased.Furthermore,M3Gd is harder and more brittle,compared with M12Gd,resulting in a more detrimental impact on the mechanical properties of alloy. 展开更多
关键词 integration of structure and function Gd duplex stainless steel neutron absorbing material mechanical properties
暂未订购 下载PDF
Structures and Functions of Cuticular Wax in Postharvest Fruit and Its Regulation:A Comprehensive Review with Future Perspectives 认领 引用 被引量：13
5
作者 Weijie Wu Bo Jiang +9 位作者 Ruiling Liu Yanchao Han Xiangjun Fang Honglei Mu Mohamed A.Farag Jesus Simal-Gandara Miguel A.Prieto Hangjun Chen Jianbo Xiao Haiyan Gao 《Engineering》 SCIE EI CAS CSCD 2023年第4期118-129,M0006,共12页
Cuticular wax plays a major role in the growth and storage of plant fruits.The cuticular wax coating,which covers the outermost layer of a fruit’s epidermal cells,is insoluble in water.Cuticular wax is mainly compose... Cuticular wax plays a major role in the growth and storage of plant fruits.The cuticular wax coating,which covers the outermost layer of a fruit’s epidermal cells,is insoluble in water.Cuticular wax is mainly composed of very long-chain fatty acids(VLCFAs);their derivatives,including esters,primary alcohols,secondary alcohols,aldehydes,and ketones;and triterpenoids.This complex mixture of lipids is probably biosynthesized in the epidermal cells of most plants and exuded onto the surface.Cuticular wax not only makes the fruit less susceptible to microbial infection but also reduces mechanical damage to the fruit,thereby maintaining the fruit’s commodity value.To date,research has mostly focused on the changes,function,and regulation of fruit wax before harvest,while ignoring the changes and functions of wax in fruit storage.This paper reviews on the composition,structure,and metabolic regulation of cuticular wax in fruits.It also focuses on postharvest factors affecting wax composition,such as storage temperature,relative humidity(RH),gas atmosphere,and as exogenous hormones;and the effects of wax on fruit postharvest quality,including water dispersion,fruit softening,physiological disorders,and disease resistance.These summaries may be of assistance in better understanding the changes in cuticular wax in postharvest fruit and the resulting effects on fruit quality. 展开更多
关键词 Cuticular wax Structure and function Postharvest Fruit quality
暂未订购 下载PDF
Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro 认领 引用 被引量：2
6
作者 Min Li Xin Wang +7 位作者 Qihui Wang Lei Yu Lanfeng Wang Jinghua Yan Fuchun Zhang Linqi Zhang George F.Gao Xia Jin 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第12期1396-1398,共3页
Dear Editor,Antibody-dependent enhancement（ADE）has long been recognized for dengue virus（DENV）in vitro and in vivo.It is now clear that antibodies to DENV can also enhance Zika virus（ZIKV）infection in vitro,and ... Dear Editor,Antibody-dependent enhancement（ADE）has long been recognized for dengue virus（DENV）in vitro and in vivo.It is now clear that antibodies to DENV can also enhance Zika virus（ZIKV）infection in vitro,and vice versa（Dejnirattisai et al.,2016;Stettler et al.,2016）.The characteristics of enhancing antibodies,however,remain elusive. 展开更多
关键词 Both structure and function human monoclonal
暂未订购 下载PDF
Effects of cadmium perturbation on the microbial community structure and heavy metal resistome of a tropical agricultural soil 认领 引用 被引量：4
7
作者 Lateef B.Salam Oluwafemi S.Obayori +1 位作者 Mathew O.Ilori Olukayode O.Amund 《Bioresources and Bioprocessing》 SCIE EI 2020年第1期513-531,共19页
The effects of cadmium(Cd)contamination on the microbial community structure,soil physicochemistry and heavy metal resistome of a tropical agricultural soil were evaluated in field-moist soil microcosms.A Cd-contamina... The effects of cadmium(Cd)contamination on the microbial community structure,soil physicochemistry and heavy metal resistome of a tropical agricultural soil were evaluated in field-moist soil microcosms.A Cd-contaminated agricultural soil(SL5)and an untreated control(SL4)were compared over a period of 5 weeks.Analysis of the physicochemical properties and heavy metals content of the two microcosms revealed a statistically significant decrease in value of the soil physicochemical parameters(P<0.05)and concentration of heavy metals(Cd,Pb,Cr,Zn,Fe,Cu,Se)content of the agricultural soil in SL5 microcosm.Illumina shotgun sequencing of the DNA extracted from the two microcosms showed the predominance of the phyla,classes,genera and species of Proteobacteria(37.38%),Actinobacteria(35.02%),Prevotella(6.93%),and Conexibacter woesei(8.93%)in SL4,and Proteobacteria(50.50%),Alphaproteobacteria(22.28%),Methylobacterium(9.14%),and Methylobacterium radiotolerans(12,80%)in SL5,respectively.Statistically significant(P<0.05)difference between the metagenomes was observed at genus and species delineations.Functional annotation of the two metagenomes revealed diverse heavy metal resistome for the uptake,transport,efflux and detoxification of various heavy metals.It also revealed the exclusive detection in SL5 metagenome of members of RND(resistance nodulation division)protein czcCBA efflux system(czcA,czrA,czrB),CDF(cation diffusion facilitator)transporters(czcD),and genes for enzymes that protect the microbial cells against cadmium stress(sodA,sodB,ahpC).The results obtained in this study showed that Cd contamination significantly affects the soil microbial community structure and function,modifies the heavy metal resistome,alters the soil physicochemistry and results in massive loss of some autochthonous members of the community not adapted to the Cd stress. 展开更多
关键词 Cadmium Agricultural soil Heavy metals Soil microcosm Shotgun metagenomics Microbial community structure and function Heavy metal resistome
暂未订购 下载PDF
Impacts of methamidophos,copper,and their combinations on bacterial community structure and function in black soil 认领 引用
8
作者 ZHANG Huiwen ZHOU Qixing +1 位作者 ZHANG Qianru ZHANG Chenggang 《Science China(Life Sciences)》 EI CAS 2005年第Z1期14-25,共12页
The potential ecotoxicologial risks of methamidophos,copper,and their combinations on microbial community of black soil ecosystem in the Northeast China were assessed in species richness and structures by using 16S rD... The potential ecotoxicologial risks of methamidophos,copper,and their combinations on microbial community of black soil ecosystem in the Northeast China were assessed in species richness and structures by using 16S rDNA-PCR-DGGE analysis approach,and functional characteristics at community levels by using BIOLOGGN system analysis method as well as two conventional methods(DHA and SIR).All results of DGGE banding fingerprint patterns(amplified by bacterial specific 16S rDNA V3 high variable region universal primer)indicated that the species richness of bacterial community in tested soil was significantly decreased to different extents by using different concentrations of single methamidophos,copper,especially some of their combinations had worse effects than their corresponding single factors.In addition,the structures of soil bacterial community had been disturbed under all stresses applied in this study because of the enrichment of some species and the disappearance of other species from the bacterial community.The effects of the single factors with lower concentrations on the communiy structure were weaker than those with higher concentrations.Moreover,the bacterial community structures under the combined stresses of methamidophos and copper were significantly different from those of control and their corresponding single factors.The change of DHA and carbon source substrate utilizing fingerprint patterns based on BIOLOGGNsystem were two relatively sensitive directors corresponding to the stress presented in this study.Between methamodophos and copper,there happened the significant joint-toxic actions when they were used in combination on DHA and carbon source substrate utilizing fingerprint patterns of soil bacterial communities.The DHA of soil under the combined stresses was lower than that of the control and that under the single factors,and the BIOLOGGN substrate utilizing patterns of soil treated by combinations were distinctively differentiated from the control and their corresponding single factors.From all of above,the methamidophos,copper,especially their combinations had the clearly potential ecotoxicological risks to influence the natural soil microbial ecological system by changing the structure,richness,and the functional characteristics of microbial community. 展开更多
关键词 and their combinations on bacterial community structure and function in black soil Impacts of methamidophos copper
暂未订购 下载PDF
Abnormal energy metabolism and tau phosphorylation in the brains of middle-aged mice in response to atmospheric PM2.5 exposure 认领 引用 被引量：9
9
作者 Rui Gao Tingting Ku +3 位作者 Xiaotong Ji Yingying Zhang Guangke Li Nan Sang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2017年第12期145-153,共9页
In light of the accelerated aging of the global population and the deterioration of the atmosphere pollution, we sought to clarify the potential mechanisms by which fine particulate matter（PM_（2.5）） can cause cogn... In light of the accelerated aging of the global population and the deterioration of the atmosphere pollution, we sought to clarify the potential mechanisms by which fine particulate matter（PM_（2.5）） can cause cognitive impairment and neurodegeneration through the alteration of mitochondrial structure and function. The results indicate that PM_（2.5） inhalation reduces ATP production by disrupting the aerobic tricarboxylic acid cycle and oxidative phosphorylation, thereby causing the hypophosphorylation of tau in the cortices of middle-aged mice. Furthermore, excessive reactive oxygen species generation was involved in the impairment. Interestingly, these alterations were partially reversed after exposure to PM_（2.5） ended. These findings clarify the mechanism involved in mitochondrial abnormality-related neuropathological dysfunction in response to atmospheric PM_（2.5） inhalation and provide an optimistic sight for alleviating the adverse health outcomes in polluted areas. 展开更多
关键词 Fine particulate matter（PM_（2.5）） Mitochondrial structure and function Energy metabolism Reactive oxygen species（ROS） Tau phosphorylation
暂未订购 下载PDF
Co-regulator NCOA5 and cancer 认领 引用
10
作者 YUANYUAN CHEN SHUAISHUAI CUI +1 位作者 YUNFEI GUO DAHU CHEN 《BIOCELL》 SCIE 2022年第7期1643-1650,共8页
NCOA5 encodes a co-regulator for estrogen receptors(ERαand ERβ),orphan nuclear receptors(REV-ERBαand REV-ERBβ)and liver X receptor.It can influence many cellular processes by either promoting or inhibiting gene ex... NCOA5 encodes a co-regulator for estrogen receptors(ERαand ERβ),orphan nuclear receptors(REV-ERBαand REV-ERBβ)and liver X receptor.It can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs:LxxLL(co-activator)andΦxxΦΦ(co-repressor).Many reports have revealed the important roles of NCOA5 in diseases,such as diabetes,reproductive defects and autoimmune disease.In this review,we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers. 展开更多
关键词 NCOA5 Co-regulator Structure and function Nuclear receptors Cancer
暂未订购 下载PDF
Flavivirus RNA cap methyltransferase:structure,function,and inhibition 认领 引用 被引量：1
11
作者 Lihui LIU Hongping DONG +5 位作者 Hui CHEN Jing ZHANG Hua LING Zhong LI Pei-Yong SHI Hongmin LI 《Frontiers in Biology》 2010年第4期286-303,共18页
Many flaviviruses are significant human pathogens.The plus-strand RNA genome of a flavivirus contains a 5′terminal cap 1 structure(m7GpppAmG).The flavivirus encodes one methyltransferase(MTase),located at the Ntermin... Many flaviviruses are significant human pathogens.The plus-strand RNA genome of a flavivirus contains a 5′terminal cap 1 structure(m7GpppAmG).The flavivirus encodes one methyltransferase(MTase),located at the Nterminal portion of the NS5 RNA-dependent RNA polymerase(RdRp).Here we review recent advances in our understanding of flaviviral capping machinery and the implications for drug development.The NS5 MTase catalyzes both guanine N7 and ribose 2'-OH methylations during viral cap formation.Representative flavivirus MTases,from dengue,yellow fever,and West Nile virus(WNV),sequentially generate GpppA!m7GpppA!m7GpppAm.Despite the existence of two distinct methylation activities,the crystal structures of flavivirus MTases showed a single binding site for S-adenosyl-L-methionine(SAM),the methyl donor.This finding indicates that the substrate GpppA-RNA must be repositioned to accept the N7 and 2'-O methyl groups from SAM during the sequential reactions.Further studies demonstrated that distinct RNA elements are required for the methylations of guanine N7 on the cap and of ribose 2'-OH on the first transcribed nucleotide.Mutant enzymes with different methylation defects can trans complement one another in vitro,demonstrating that separate molecules of the enzyme can independently catalyze the two cap methylations in vitro.In the context of the infectious virus,defects in both methylations,or a defect in the N7 methylation alone,are lethal to WNV.However,viruses defective solely in 2'-O methylation are attenuated and can protect mice from later wild-typeWNV challenge.The results demonstrate that the N7 methylation activity is essential for the WNV life cycle and,thus,methyltransferase represents a novel and promising target for flavivirus therapy. 展开更多
关键词 Flavivirus NS5 RNA cap methylation methyltransferase structure and function inhibitor
暂未订购 下载PDF
Review of forest ecology studies in China 认领 引用 被引量：5
12
作者 王庆礼 邓红兵 +1 位作者 王绍先 李杨 《Journal of Forestry Research》 CAS 2002年第3期231-234,252,共4页
As the most important type or component in the terrestrial ecosystems, forest ecosystem makes its role obviously prominent and important on environment and human being. It possesses non-substitutable functions in the ... As the most important type or component in the terrestrial ecosystems, forest ecosystem makes its role obviously prominent and important on environment and human being. It possesses non-substitutable functions in the process of sustainable development. However, due to the complexity of the forest ecosystem and the relatively delay or lack of the related research technology, the science is still in the case of immature and questions. This paper summarized and reviewed briefly the development and the present case of the forest ecology, then pointed out the existing problems in the forest ecosystem researches. In the end, we discussed several fields that need to pay more attention to in future researches. 展开更多
关键词 Forest Ecosystem Forest ecology Structure and function Management Health Watershed
暂未订购 下载PDF
Instant Effects of Radiofrequency Electromagnetic Wave on Hemoglobin in Single Living Intact Red Blood Cell 认领 引用 被引量：1
13
作者 Cheng Can YAO Xiao Kun LI Yao Xiong HUANG 《Chinese Chemical Letters》 SCIE CAS 2005年第8期1121-1124,共4页
The absorption spectrum of the hemoglobin （Hb） in single riving intact red blood cell（RBC）, exposed in 900 MHz radiofrequency electromagnetic wave （RF-EMW）, was non-invasive,in situ, real-time measured by employ... The absorption spectrum of the hemoglobin （Hb） in single riving intact red blood cell（RBC）, exposed in 900 MHz radiofrequency electromagnetic wave （RF-EMW）, was non-invasive,in situ, real-time measured by employing a highly sensitive fast multi-channel microspectrophotometer system. Both the absorption intensity and site of intracellular Hb were altered after RBCs were exposed in 900 MHz RF-EMW with power density at 5 mW/cm^2. It was indicated that not only the concentration of Hb in living RBCs was decreased, but the molecular structure of Hb was changed by the RF-EMW action. 展开更多
关键词 Radiofrequency electromagnetic wave hemoglobin absorption spectrum structure and function.
暂未订购 下载PDF
Soil micro-food web composition determines soil fertility and crop growth 认领 引用 被引量：2
14
作者 Yaping Lin Qing Yi +6 位作者 Dandan Gao Jiangnan Li Wei Zhang Kelin Wang Dan Xiao Peilei Hu Jie Zhao 《Soil Ecology Letters》 CSCD 2025年第1期145-157,共13页
Soil fertility is one of the key determinants of agricultural productivity.Soil food webs play an important role in driving soil nutrient cycling and plant health.However,it is poorly known how the soil food web compo... Soil fertility is one of the key determinants of agricultural productivity.Soil food webs play an important role in driving soil nutrient cycling and plant health.However,it is poorly known how the soil food web composition and complexity affect plant growth and soil fertility.In this study,soil microorganisms and nematodes isolated from two soil types(i.e.,calcareous soil and red soil)and two land use types(i.e.,corn-soybean cultivation and natural grass-shrubland)were used to sequentially establish four soil microfood webs(FW1,FW2,FW3,and FW4)with increasing levels of community complexity based on food web complexity.The four micro-food webs were inoculated to sterilized soils which were then planted with soybeans for three months in a pot experiment under ambient environment.The sterilized soil without food web inoculation was employed as control(C)and unsterilized soil with its original food web was also regarded as a treatment(US)in the experiment.The effects of soil micro-food web complexity on soil nutrient and soybean growth were explored.The results showed that soil total nitrogen(TN)and phosphorus(TP),soil microbial biomasses,and plant nitrogen and phosphorus were generally higher in the four food web inoculation treatments than in the control or unsterilized soil.Surprisingly,the original soil food web treatment(i.e.,unsterilized soil)had lower soil or soybean nutrient than the no food web treatment(i.e.,sterilized soil).In addition,the complexity of inoculated food webs was positively correlated with soil TN,TP,and total potassium(TK).These results suggest that soil micro-food web complexity is an important driver of soil fertility and affects crop growth.Particularly,complex soil micro-food web maintains higher soil fertility and crop growth.This study provides solid evidence of the roles of soil food web in controlling ecosystem services;and the findings could provide a better understanding of the soil food web structure and soil fertility relationships. 展开更多
关键词 network complexity microbes and nematodes soil fertility soil community inoculation structure and function relationship
Advancements and future perspectives in the study of oligosaccharides derived from edible-medicinal mushrooms 认领 引用 被引量：2
15
作者 Shuo Wang Jiajie Qi +6 位作者 Xiaoming Cai Weijie Wu Zhuo AWang Siming Jiao Caihong Dong Yi Li Zhenquan Yang 《Food Bioscience》 SCIE 2024年第5期578-592,共15页
Recent studies have underscored the unique biological activities of oligosaccharides derived from ediblemedicinal mushrooms,highlighting their superiority over polysaccharides due to their simpler structures and incre... Recent studies have underscored the unique biological activities of oligosaccharides derived from ediblemedicinal mushrooms,highlighting their superiority over polysaccharides due to their simpler structures and increased bioavailability.Investigating the structure-activity relationship of oligosaccharides could help overcome the technical challenges associated with the intricate structural analysis of polysaccharides.Despite numerous studies on oligosaccharide compounds,our understanding of oligosaccharides from edible-medicinal mushrooms remains limited.This review aims to outline current trends in oligosaccharide research and clarify the health-promoting characteristics of oligosaccharides derived from edible-medicinal mushrooms.It offers a comprehensive analysis of the glycan chain structures and biological activities of oligosaccharides and advocates for the establishment of an oligosaccharide compound library specific to edible-medicinal mushrooms.This approach might expedite the high-throughput screening of active oligosaccharides,thus stimulating the development of related health foods and products,and facilitating industrial advancement. 展开更多
关键词 oligosaccharide Edible-medicinal mushroom Plant polysaccharide Biological activity Structure and function
In the flow of connectivity:A dynamic network analysis of Europe’s air transportation system 认领 引用
16
作者 Katrin Kolker Emily Stoebke Klaus Lütjens 《Journal of the Air Transport Research Society》 2025年第1期268-283,共16页
The topological structure of the air transport network is complex and can be analyzed with different approaches,measures and perspectives.In this study a dynamic network analysis is utilized and an additional function... The topological structure of the air transport network is complex and can be analyzed with different approaches,measures and perspectives.In this study a dynamic network analysis is utilized and an additional functional layer,passenger flows,is defined to analyze the flow of connectivity.Therefore,the approach provides additional and differentiated results to assess the European air transport network.The study is based on a time series of monthly European demand and schedule data for the years 2010-2023.This makes the study relevant for the recent evaluation of the European air transport network.The study aims to measure the connectivity of the intra-European network and how this connectivity changes over time.The view on connectivity is extended from accessibility and connectivity to two additional perspectives,competition and robustness.The flow of connec-tivity is assessed using dynamic network analysis,which identifies trends,standard deviation and mean absolute change.This allows comparison of the entire network over time as well as comparisons between airports.This paper introduces a framework that integrates and categorizes a broad range of network analysis measures.It provides a foundation for future developments and practical applications across diverse use cases and other networks.The study demonstrates that the connectivity of the network undergoes changes over time,both in terms of trend and in terms of similarity between airports,with differences evident in the four different perspectives.The accessibility among airports is becoming more uniform,indicating a convergence in connectivity measures.At the same time,airports are becoming increasingly interconnected with less relative importance of hubs.How-ever,the passenger utilization becomes more diverse.Competition among airports has been steadily increasing.Additionally,there is a correlation between demand,competition,and the network’s structure.In less competitive markets,there are fewer travelers and reduced capacity,and airports often exhibit weaker centrality within the network. 展开更多
关键词 Dynamic network analysis Structure and function of airline networks Connectivity of European air transport network
Gastrointestinal tract(gut) health in the young pig 认领 引用 被引量：53
17
作者 John R.Pluske Diana L.Turpin Jae-Cheol Kim 《Animal Nutrition》 SCIE CAS 2018年第2期187-196,共10页
An optimally functioning gastrointestinal tract(GIT) clearly is of importance to the overall metabolism,physiology, disease status and performance of pigs of all stages of growth and development.Recently, the‘health... An optimally functioning gastrointestinal tract(GIT) clearly is of importance to the overall metabolism,physiology, disease status and performance of pigs of all stages of growth and development.Recently, the‘health’ of the GIT(‘gut health’) has attracted much attention despite the lack of a clear definition to the term or its aetiology, although in broad terms, ‘gut health’ encompasses a number of physiological and functional features including nutrient digestion and absorption, host metabolism and energy generation, a stable and appropriate microbiota/microbiome, defence mechanisms including barrier function and mucosal immune mechanisms, and the interactions between these components.‘Gut health’ in the newlyweaned(young) pig is of obvious interest due to changes in GIT structure and function associated with the post-weaning transition, and more recently to the upsurge in interest in different feed additives as dietary alternativeseplacements caused by banseductions in certain antimicrobial compounds being available in some parts of the world.In the presence of enteric disease(s) after weaning, a deterioration in ‘gut health’ may be synonymous to the overall health of the pig, and although some direct relationships can be drawn between pig performance and efficiency and a ‘healthy' GIT, sometimes this connection is subtler and less obvious, especially in the absence of overt enteric disease(s).The factors and conditions involved in ‘gut health’ are multifactorial, complex, often poorly described and sometimes incorrectly interpreted,although it is evident that perturbations of the GIT can cause an imbalance and disturb the generalized homeostasis.In addition to any enteric diseases or conditions that might arise as a result of these disturbances, other influences will also impact such as the responses occurring in the GIT in the period immediately after weaning, any changes that might occur after a change in diet, and(or) disruptions to meal patterns and hence the flow of nutrients.Ultimately, ‘gut health’ represents the outcome of the GIT in response to its capacity and ability to respond and adapt to the insults and challenges it encounters. 展开更多
关键词 Gastrointestinal tract Gut health Structure and function Pig Piglet Weaning
暂未订购 下载PDF
The perinucleolar compartment associates with malignancy 认领 引用
18
作者 Yiping WEN Chen WANG Sui HUANG 《Frontiers in Biology》 CSCD 2013年第4期369-376,共8页
The perinucleolar compartment （PNC） is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence （percentage of cells containing at least one PNC） has been foun... The perinucleolar compartment （PNC） is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence （percentage of cells containing at least one PNC） has been found to positively correlate with disease progression in several cancers （breast, ovarian, and colon）. While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells. 展开更多
关键词 PNC cancer nuclear substructure gene expression regulation structure and function
暂未订购 下载PDF
Human catalase: looking for complete identity 认领 引用 被引量：18
19
作者 Madhur M.Goyal Anjan Basak 《Protein & Cell》 SCIE 2010年第10期888-897,共10页
Catalases are well studied enzymes that play critical roles in protecting cells against the toxic effects of hydrogen peroxide.The ubiquity of the enzyme and the availability of substrates made heme catalases the focu... Catalases are well studied enzymes that play critical roles in protecting cells against the toxic effects of hydrogen peroxide.The ubiquity of the enzyme and the availability of substrates made heme catalases the focus of many biochemical and molecular biology studies over 100 years.In human,this has been implicated in various physiological and pathological conditions.Advancement in proteomics revealed many of novel and previously unknown features of this mysterious enzyme,but some functional aspects are yet to be explained.Along with discussion on future research area,this mini-review compile the information available on the structure,function and mechanism of action of human catalase. 展开更多
关键词 human catalase structure and function mechanism of action futuristic research area
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈