Drug discovery has begun to move beyond traditional targets,turning instead to more complex target landscapes.These complex targets,including membrane proteins,are characterized by their environment and conformational...Drug discovery has begun to move beyond traditional targets,turning instead to more complex target landscapes.These complex targets,including membrane proteins,are characterized by their environment and conformational mobility.A limitation of traditional in vitro screening is that the target protein is not in its native environment.As a result,there is a need to go beyond current methods,this will allow you to study a target proteins functional activity in their native environment.展开更多
A fast algorithm based on the grayscale distribution of infrared target and the weighted kernel function was proposed for the moving target detection(MTD) in dynamic scene of image series. This algorithm is used to de...A fast algorithm based on the grayscale distribution of infrared target and the weighted kernel function was proposed for the moving target detection(MTD) in dynamic scene of image series. This algorithm is used to deal with issues like the large computational complexity, the fluctuation of grayscale, and the noise in infrared images. Four characteristic points were selected by analyzing the grayscale distribution in infrared image, of which the series was quickly matched with an affine transformation model. The image was then divided into 32×32 squares and the gray-weighted kernel(GWK) for each square was calculated. At last, the MTD was carried out according to the variation of the four GWKs. The results indicate that the MTD can be achieved in real time using the algorithm with the fluctuations of grayscale and noise can be effectively suppressed. The detection probability is greater than 90% with the false alarm rate lower than 5% when the calculation time is less than 40 ms.展开更多
Parkinson's disease (PD) is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases a...Parkinson's disease (PD) is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity (bradykinesia), and postural instability and pathological- ly by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of Lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.展开更多
摘要Drug discovery has begun to move beyond traditional targets,turning instead to more complex target landscapes.These complex targets,including membrane proteins,are characterized by their environment and conformational mobility.A limitation of traditional in vitro screening is that the target protein is not in its native environment.As a result,there is a need to go beyond current methods,this will allow you to study a target proteins functional activity in their native environment.
基金Project(61101185)supported by the National Natural Science Foundation of China
摘要A fast algorithm based on the grayscale distribution of infrared target and the weighted kernel function was proposed for the moving target detection(MTD) in dynamic scene of image series. This algorithm is used to deal with issues like the large computational complexity, the fluctuation of grayscale, and the noise in infrared images. Four characteristic points were selected by analyzing the grayscale distribution in infrared image, of which the series was quickly matched with an affine transformation model. The image was then divided into 32×32 squares and the gray-weighted kernel(GWK) for each square was calculated. At last, the MTD was carried out according to the variation of the four GWKs. The results indicate that the MTD can be achieved in real time using the algorithm with the fluctuations of grayscale and noise can be effectively suppressed. The detection probability is greater than 90% with the false alarm rate lower than 5% when the calculation time is less than 40 ms.
基金supported by the Ministry of Health and Department of Educational Assistance,University and Research of the Autonomous Province of Bolzano
摘要Parkinson's disease (PD) is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity (bradykinesia), and postural instability and pathological- ly by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of Lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.