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A New Chapter in Translational Neurology and Neurosurgery 认领 引用
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作者 Xunming Ji 《Translational Neurology and Neurosurgery》 2026年第1期1-2,共2页
This new title signifies far more than a formal change in name.It marks a renewed commitment to advancing translational scholarship in neurology and neurosurgery at a time when scientific discovery is accelerating at ... This new title signifies far more than a formal change in name.It marks a renewed commitment to advancing translational scholarship in neurology and neurosurgery at a time when scientific discovery is accelerating at an unprecedented pace,while the pathway from laboratory insight to clinical implementation remains both challenging and essential.In adopting this title,we reaffirm our mission to serve as an international platform for rigorous,high-impact research that bridges basic science,clinical investigation,and patient-centred medical practice. 展开更多
关键词 scientific discovery translational scholarship laboratory insight clinical implementation advancing translational scholarship neurology neurosurgery rigorous research
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Research framework for scientific innovation and translational application of original acupuncture theories:a review based on Hand Twelve Jing-Well Points stimulation therapy 认领 引用
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作者 Yu Luo Zheng Zhu +10 位作者 Feifei Gao Dan Zhou Ningcen Li Zhongxi Lyu Liang Zhou Siru Qin Yuanzhen Yang Baoming Dou Ning Ma Yi Guo Zhifang Xu 《Acupuncture and Herbal Medicine》 CAS CSCD 2026年第1期42-55,共14页
The field of acupuncture is currently facing paradigmatic issues,including the difficulty of turning theoretical strengths into technical discourse power,a gap between mechanistic research and clinical imperatives,and... The field of acupuncture is currently facing paradigmatic issues,including the difficulty of turning theoretical strengths into technical discourse power,a gap between mechanistic research and clinical imperatives,and the fragmentation of research activities.Therefore,constructing a research paradigm grounded in traditional Chinese medicine theory and validated through contemporary scientific methods is essential.Hand Twelve Jing-Well Points(HTWP)acupuncture,an ancient therapy known for its rapid efficacy and practical application,offers an optimal solution for these challenges.In this study,the theoretical foundations,clinical effectiveness,biological explanations,and Translational applications of HTWP acupuncture were consolidated by integrating a four-step research framework.Initially,we developed the“Well point-Brain Connection”framework rooted in classical theories and informed by the“Root-Knot”concept.Subsequent clinical practice provided evidence of its effectiveness in modulating awareness and facilitating motor-cognitive rehabilitation for patients with central nervous system issues.Moreover,mechanistic research provides scientific verification of a“Sensation-Transmission-Effect”cascade that encompasses the activation of arousal circuits and the repair of the blood-brain barrier.Ultimately,the promotion of translation,standardization of systems,and the use of wearable technologies have aided the transition from passive therapy to proactive health management.This closed-loop concept offers compelling evidence for the“Well point-Brain Connection”and provides an applicable framework for scientific innovation and global distribution of innovative acupuncture hypotheses. 展开更多
关键词 Acupuncture Central nervous system diseases Hand Twelve Jing-Well Points Research paradigm Translational medicine Well point-brain connection
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GrpE-like 1-engineered synovial mesenchymal stromal cell exosomes:Mechanistic and translational priorities in osteoarthritis 认领 引用
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作者 Zhen Shi Hao-Yu Li +5 位作者 Bo-Kang Lv Dong Li Peng-Yu Lu Xin-Yu Zhou Meng-En Xue Rui-Bo Wang 《World Journal of Stem Cells》 SCIE 2026年第5期9-21,共13页
Osteoarthritis(OA)remains a highly prevalent degenerative joint disorder for which truly disease-modifying therapies are still lacking.Accumulating evidence positions mitochondrial dysfunction and impaired mitochondri... Osteoarthritis(OA)remains a highly prevalent degenerative joint disorder for which truly disease-modifying therapies are still lacking.Accumulating evidence positions mitochondrial dysfunction and impaired mitochondrial quality control as central drivers of chondrocyte failure,extracellular matrix breakdown,and inflammation amplification.Mitophagy—particularly the phosphatase and tensin homolog-induced kinase 1(PINK1)/Parkin axis—has therefore emerged as an attractive,mechanistically grounded intervention point.In this context,synovial mesenchymal stem cell-derived exosomes(SMSC-Exos)represent a compelling cell-free platform capable of delivering functional biomolecules into inflamed cartilage microenvironments.Recent experimental work demonstrates that engineering SMSC-Exos to deliver the mitochondrial co-chaperone GrpE-like 1(GRPEL1)restores chondrocyte proliferative and migratory capacity under interleukin-1βstress,preserves anabolic extracellular matrix markers(collagen type II alpha 1/aggrecan),suppresses catabolic mediators(matrix metalloproteinase 13/A disintegrin and metalloproteinase with thrombospondin motifs 5),and mitigates oxidative damage while enhancing mitophagy signatures.Mechanistically,GRPEL1 directly associates with PINK1,and PINK1 knockdown attenuates the protective phenotype,supporting a GRPEL1-PINK1 coupling model.In vivo,intra-articular administration of GRPEL1-enriched SMSC-Exos improves histological cartilage integrity and mitophagy-related readouts in a rat OA model.Here,we synthesize mechanistic implications,highlight interpretive nuances(e.g.,mitophagy activation concurrent with membrane potential recovery),and outline translational priorities,including cargo quantification,mitophagy flux validation,dosingetention kinetics,manufacturing standardization,and biomarker-driven patient stratification. 展开更多
关键词 Cartilage regeneration Engineered exosomes GrpE-like 1 Mesenchymal stromal cells Mitophagy Mitochondrial homeostasis Mitochondrial quality control Osteoarthritis Phosphatase and tensin homolog-induced kinase 1 Translational therapeutics
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Recent advances in the construction of humanized animal models and applications in translational medicine 认领 引用
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作者 Yanan Lyu Yong-Guang Yang Zheng Hu 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期914-931,共18页
Over the past several decades,humanized mouse models have undergone significant refinement and become essential tools in biomedical research.Advances in genetic engineering,particularly the targeted knock-in of human ... Over the past several decades,humanized mouse models have undergone significant refinement and become essential tools in biomedical research.Advances in genetic engineering,particularly the targeted knock-in of human cytokines,have enabled robust development and function of human immune cells in these models.Recent breakthroughs-including the directed differentiation of human pluripotent stem cells into thymic epithelial cells and the efficient expansion of hematopoietic stem cells-have alleviated the constraint of scarce human tissue sources.Furthermore,the reconstruction of lymph node structures and successful engraftment of solid organ tissues have significantly improved the efficiency and physiological relevance of human immune system reconstitution.These models now provide a unique plat-form for in vivo studies in cancer immunotherapy,infectious diseases,regenerative medicine,and autoimmune disorders under near-physiological conditions.Beyond rodents,substantial progress in humanized large animals,such as pigs,offers prom-ising avenues for large-scale immune system reconstruction and mass production of immunotherapeutic cells.This review presents a comprehensive overview of the development,optimization,and expanding applications of humanized animal models,highlighting their transformative role in advancing translational medicine. 展开更多
关键词 cancer immunotherapy disease models humanized animal models regenerative medicine translational medicine
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Digital neuroplasticity modulation of the brain-immune axis:Translational strategies for neurodegenerative,psychiatric,and aging-related conditions 认领 引用
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作者 Merav Catalogna Amir Amedi 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4914-4915,共2页
The brain-immune axis:The dynamic interplay between neural and immune systems is emerging as a fundamental regulator of cognitive processes,affective balance,and resilience to pathological challenges(Castellani et al.... The brain-immune axis:The dynamic interplay between neural and immune systems is emerging as a fundamental regulator of cognitive processes,affective balance,and resilience to pathological challenges(Castellani et al.,2023).Although these systems detect and respond to distinct types of stimuli,their domains of perception and response substantially overlap. 展开更多
关键词 psychiatric conditions translational strategies brain immune axis digital neuroplasticity modulation neural immune systems affective balance cognitive processes neurodegenerative conditions
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Preface to Special Issue: AI-driven comprehensive cancer therapy: Strategy construction, basic and translational research 认领 引用
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作者 Lei Zhu 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2026年第2期119-120,共2页
Welcome to the special issue entitled AI-driven comprehensive cancer therapy:Strategy construction,basic and translational research at the Chinese Journal of Cancer Research.Artificial intelligence(AI)is systematicall... Welcome to the special issue entitled AI-driven comprehensive cancer therapy:Strategy construction,basic and translational research at the Chinese Journal of Cancer Research.Artificial intelligence(AI)is systematically revolutionizing comprehensive cancer treatment strategies,driving breakthroughs in diagnosis and treatment models at multiple levels. 展开更多
关键词 diagnosis treatment models cancer treatment strategiesdriving basic research translational research diagnosis treatment models strategy construction artificial intelligence
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Comprehensive modeling of the Correa cascade in precancerous lesions of gastric cancer:Leveraging animal,cellular,and organoid systems for translational insights 认领 引用
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作者 Li-Jie Zhou Xin-Yu Hao +2 位作者 Chen Wang Ning-Ning Ren Yan-Gang Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第3期238-261,共24页
BACKGROUND Precancerous lesions of gastric cancer(PLGC),including chronic atrophic gastritis,intestinal metaplasia,and dysplasia,constitute key transitional stages in the Correa cascade toward gastric cancer.Understan... BACKGROUND Precancerous lesions of gastric cancer(PLGC),including chronic atrophic gastritis,intestinal metaplasia,and dysplasia,constitute key transitional stages in the Correa cascade toward gastric cancer.Understanding these stages is essential for early detection,prevention,and therapeutic intervention.AIM To provide a comprehensive and critical overview of current animal,cellular,and organoid models used in PLGC research,emphasizing their applications,translational relevance,and emerging technologies.METHODS A scoping systematic review was performed according to the PRISMA-ScR framework.Literature was identified from PubMed and Web of Science up to June 2025 using predefined keywords and Boolean operators.Eligible studies included experimental reports describing animal,cellular,or organoid models of PLGC.Two authors independently screened titles,abstracts,and full texts,and relevant data were charted and synthesized narratively.RESULTS This study delineates the modeling strategies for PLGC across various platforms.Animal models,including chemical induction with N-methyl-N’-nitro-N-nitrosoguanidine,N-nitroso-N-methylurea,Helicobacter pylori infection,transgenic approaches,and composite modeling,recapitulate the histopathological spectrum of PLGC and facilitate mechanistic discovery.Cellular models simulate chronic inflammation and carcinogen exposure,enabling high-throughput mechanistic screening.Gastric organoids derived from patients or animals offer a physiologically relevant three-dimensional culture system,reproducing epithelial transformation and Helicobacter pylori-induced pathology,with recent advances in co-culture systems and immune-organoid interactions.Integration of gene editing,single-cell transcriptomics,and organoid-on-chip platforms is expected to further refine PLGC modeling and accelerate clinical translation.CONCLUSION Integrated PLGC models provide a robust framework for elucidating the cellular and molecular basis of early gastric tumorigenesis.Their continued evolution will enhance biomarker discovery,immunologic investigation,and therapeutic development. 展开更多
关键词 Precancerous lesions of gastric cancer Correa cascade Animal model Cellular model Organoid Helicobacter pylori Tumor microenvironment Translational research
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Ferroptosis as a Translational Axis in Small Cell Lung Cancer:A Systematic Review of Redox Pathways and Precision Oncology Prospects 认领 引用
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作者 Donatella Coradduzza Anna La Salvia +1 位作者 Giuseppe Fanciulli Maria Rosaria De Miglio 《Oncology Research》 SCIE 2026年第4期122-157,共36页
Background:An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer(SCLC).The systematic review aimed to summarize the characteristics of ferro... Background:An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer(SCLC).The systematic review aimed to summarize the characteristics of ferroptosis from its pathogenetic role to translational therapeutic implications in SCLC.Methods:This systematic review,registered in PROSPERO(CRD420251090058),followed PRISMA 2020 guidelines.Comprehensive research of PubMed,Scopus,and Web of Science was performed for studies published between January 2010 and July 2025 investigating ferroptosis mechanisms,genetic or pharmacological modulation,or molecular profiling in SCLC.Two reviewers independently performed data extraction and quality assessment.Results:Nineteen preclinical studies met the inclusion criteria.Key regulators included solute carrier family 7 member 11(SLC7A11),glutathione peroxidase 4(GPX4),ferroptosis suppressor protein 1(FSP1),and acyl-CoA synthetase long chain family member 4(ACSL4).The molecular subtypes of SCLC,achaete-scute homolog 1(ASCL1),neuronal differentiation 1(NEUROD1),POU class 2 homeobox 3(POU2F3),and Yes1 associated transcriptional regulator(YAP1)exhibit differential ferroptosis gene expressions,influencing therapeutic responsiveness.Non-neuroendocrine subtypes are more ferroptosis-prone,whereas neuroendocrine variants display enhanced antioxidant defenses.Ferroptosis induction also promotes immune activation through stimulator of interferon genes(STING)-mediated CD8+T-cell recruitment.Conclusions:Ferroptosis constitutes a promising therapeutic axis in SCLC.Integrating ferroptosis biomarkers into molecular stratification frameworks could refine patient selection and support precision oncology strategies,warranting further translational and clinical validation. 展开更多
关键词 Small cell lung cancer ferroptosis lipid peroxidation glutathione peroxidase 4 solute carrier family 7 member 11 molecular subtypes immunotherapy oxidative stress regulated cell death translational oncology systematic review
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Equine models in translational medicine:A comparative approach to human health 认领 引用
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作者 Shayan Boozarjomehri Amnieh Katarzyna Ropka-Molik 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期898-913,共16页
The horse is a distinctive translational model for bridging mechanistic discovery and clinically relevant investigation because of its physiological complexity,long lifespan,athletic phenotype,and broad spectrum of na... The horse is a distinctive translational model for bridging mechanistic discovery and clinically relevant investigation because of its physiological complexity,long lifespan,athletic phenotype,and broad spectrum of naturally occurring conditions that parallel aspects of human health and disease.Its utility extends from musculoskeletal and joint research to immunology,metabolic disorders,and exercise physiology,particularly where naturally developed disease,clinically applicable imaging,and longitudinal sampling are required.Additionally,it offers opportunities to examine both chronic and acute pathological processes in a setting that closely approximates clinical reality.Advances in molecular profiling,imaging technologies,and biomarker discovery have expanded the scope of equine-based studies,enabled refined mechanistic insights,and facilitated translational strategies.The integration of equine research into comparative medicine frameworks holds promise for accelerating therapeutic innovation within comparative and One-Health,improving health outcomes across species. 展开更多
关键词 animal models comparative medicine equine model One Health translational research
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Preclinical Models of Colorectal Cancer Liver Metastasis:Therapeutic Evaluation and Translational Implications 认领 引用
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作者 Ye Ri Han Sang Bong Lee 《Oncology Research》 SCIE 2026年第7期205-233,共29页
Colorectal cancer liver metastasis(CRLM)remains a leading cause of cancer-related mortality,with clinical outcomes limited by biological heterogeneity and inconsistent therapeutic responses.Despite advances in systemi... Colorectal cancer liver metastasis(CRLM)remains a leading cause of cancer-related mortality,with clinical outcomes limited by biological heterogeneity and inconsistent therapeutic responses.Despite advances in systemic chemotherapy,targeted agents,immunotherapy,and liver-directed interventions,the translation of preclinical efficacy into clinical benefit remains suboptimal,highlighting the need for predictive experimental models.However,therapeutic efficacy in CRLM is highly model-dependent,and discrepancies between preclinical findings and clinical outcomes often arise from differences in biological fidelity across experimental platforms.This review critically examines preclinical platforms used to study CRLM,with emphasis on orthotopic and metastatic models that recapitulate hepatic colonization,tumor–microenvironment interactions,and immune regulation.We evaluate methodological innovations that enhance anatomical fidelity and reproducibility,including tissue adhesive–based implantation and biomaterial-assisted strategies.Importantly,we analyze how different models influence therapeutic assessment across systemic,immune-based,metabolic,and liver-directed treatments,and discuss their ability to predict clinical responses.By integrating insights from experimental studies with key clinical evidence,we delineate the strengths and limitations of current platforms and propose principles for rational model selection to improve translational success in CRLM research. 展开更多
关键词 Colorectal cancer liver metastasis(CRLM) orthotopic tumor models liver-directed therapy tumor microenvironment immunotherapy translational research
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The medicinal value of ginseng:phytochemistry,pharmacological actions,and translational applications 认领 引用
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作者 Xiao-Ke Li Jun Kang 《Traditional Medicine Research》 2026年第11期66-85,共20页
Panax ginseng C.A.Meyer,a foundational medicinal plant in traditional medicine,exhibits broad pharmacological effects primarily mediated by structurally diverse ginsenosides and bioactive polysaccharides.These constit... Panax ginseng C.A.Meyer,a foundational medicinal plant in traditional medicine,exhibits broad pharmacological effects primarily mediated by structurally diverse ginsenosides and bioactive polysaccharides.These constituents orchestrate multi-target regulation through key molecular hubs,including Nrf2/ARE,AMPK/SIRT,NF-κB/MAPK signaling,and microbiota–bile acid axes,contributing to hepatoprotective,neuroprotective,antitumor,and metabolic functions.Clinical translation remains constrained by major challenges:low oral bioavailability of primary ginsenosides(<5%),variability in phytochemical composition due to cultivation and processing,and incomplete understanding of synergistic multi-component mechanisms.Emerging technologies are now actively addressing these bottlenecks.Advanced nanodelivery systems enhance solubility,prolong systemic circulation,and promote targeted tissue accumulation.Ginsenoside-integrated liposomes mitigate accelerated blood clearance,while exosome-mimetic nanoparticles improve penetration across biological barriers,enabling precise delivery.Concurrently,precision bioengineering leverages CRISPR-based metabolic pathway optimization and engineered microbial platforms to achieve scalable,standardized production of rare ginsenosides at gram-per-liter levels.Artificial intelligence further accelerates translational research by guiding target identification,metabolic pathway analysis,and cultivation optimization.The integrated application of nanotechnology,synthetic biology,and AI establishes a next-generation translational framework,transforming ginseng into a source of molecularly defined,evidence-based therapeutics. 展开更多
关键词 Ginsenosides nanodelivery precision bioengineering molecular targets translational medicine
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Human umbilical cord mesenchymal stem cells in irritable bowel syndrome:Mechanistic and translational insights 认领 引用
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作者 Eric Michael Kunz Joseph Patrick Carroll +1 位作者 Russell James Schoeller III Brandon Lucke-Wold 《World Journal of Stem Cells》 SCIE 2026年第7期21-28,共8页
Diarrhea-predominant irritable bowel syndrome(IBS-D)is a prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and loose stools,increasingly recognized as a condition driven by low-gra... Diarrhea-predominant irritable bowel syndrome(IBS-D)is a prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and loose stools,increasingly recognized as a condition driven by low-grade inflammation,epithelial barrier dysfunction,and disturbances of the gut microbiota rather than purely disordered motility.In the recent issue of World Journal of Stem Cells,Zhang et al report that human umbilical cord-derived mesenchymal stem cells(hUCMSCs)ameliorate IBS-D-like disease in rats by attenuating mucosal inflammation,restoring tight junction protein expression,and stabilizing the intestinal microbiome.This editorial critically appraises their work from a translational perspective,highlighting the novelty of targeting the gut-immune-microbiome axis with hUC-MSCs in a functional bowel disorder.We discuss potential mechanisms of action,including paracrine immunomodulation,epithelial repair,and microbiome-short chain fatty acid-immune cross-talk,and relate these to current concepts of IBS-D pathophysiology.Key limitations of the animal data,gaps in human evidence,and challenges for clinical translation-such as patient selection,optimal dosing and delivery,and regulatory demands for advanced therapy medicinal products-are addressed.Finally,we propose priorities for early-phase clinical trials that integrate mechanistic biomarkers with patient-centered outcomes to determine whether hUC-MSCs can transition from experimental therapy to a realistic,disease-modifying option for IBS-D. 展开更多
关键词 Irritable bowel syndrome Mesenchymal stem cells Umbilical cord Intestinal mucosa Diarrhea Microbiota Translational medical research Cell-and tissue-based research
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Pleiotropic regulation of mitochondrial translational factors in governing proliferation,apoptosis and metastasis during cancer progression 认领 引用
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作者 Nikita Agarwal Uttam Sharma +13 位作者 Akshi Shree Rajiv Ranjan Kumar Jaya Kanta Gorain Vaishnavi Vishwas Farhana Jahan Archna Singh Jayanth Kumar Palanichamy Deepam Pushpam Radhika Bakhshi Anita Chopra Ranjit Kumar Sahoo Atul Batra Surender K Sharawat Sameer Bakhshi 《World Journal of Clinical Oncology》 2026年第1期53-73,共21页
Mitochondrial translation relies on the coordinated activity of mitoribosomes,mitochondrial ribosome proteins,mitochondria-specific transfer RNAs,and dedicated translation factors,including mitochondrial initiation fa... Mitochondrial translation relies on the coordinated activity of mitoribosomes,mitochondrial ribosome proteins,mitochondria-specific transfer RNAs,and dedicated translation factors,including mitochondrial initiation factor 2/3,mitochondrial elongation factor Tu,mitochondrial elongation factor Ts,mitochondrial elongation factor G1/G2,mitochondrial elongation factor 4,mitochondrial ribosome recycling factor,and mitochondrial release factor 1A.These components collectively drive the synthesis of 13 essential polypeptides encoded by mitochondrial DNA,all constituting subunits of the oxidative phosphorylation complexes.Although mitochondrial metabolism is increasingly recognized as a key player in cancer,the specific contribution of mitochondrial translation to cancer progression remains poorly explored.This gap in knowledge limits our understanding of how mitochondrial dysfunction contributes to tumor initiation,progression,and therapy resistance.Herein,in this review,we highlight how dysregulation of mitochondrial translation factors can influence major cancer hallmarks such as sustained proliferative signaling,resistance to apoptosis,and increased invasion and metastasis.In addition,we discuss the known molecular mechanisms that link defects in mitochondrial translation to oncogenic features.We also consolidate current insights into the mitochondrial translation machinery and discuss recent evidence of its role in cancer,aiming to emphasize mitochondrial translation as a contributor to malignancy and a potential therapeutic target. 展开更多
关键词 Mitochondrial translation Hallmark Cancer Mitochondrial translation factors Mitochondrial ribosomal proteins
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Recent advances in animal models for pathological scar research:A comprehensive review of experimental approaches and translational relevance 认领 引用
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作者 Diana-Larisa Ancuța Mariana Văduva +1 位作者 Cristin Coman Iuliana Caraș 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第1期59-71,共13页
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul... Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies. 展开更多
关键词 animal model experiment hypertrophic scar keloid scar translation
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Post-translational modifications in osteogenic differentiation of oralderived stem cells:Mechanisms and clinical implications 认领 引用
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作者 Zhuo-Jin Shi Wei Liu 《World Journal of Stem Cells》 SCIE 2025年第9期79-96,共18页
Osteogenesis is driven by the differentiation of osteoblasts and the mineralization of the bone matrix,with oral-derived stem cells playing a significant role in this process.Various post-translational modifications(P... Osteogenesis is driven by the differentiation of osteoblasts and the mineralization of the bone matrix,with oral-derived stem cells playing a significant role in this process.Various post-translational modifications(PTMs),such as phosphorylation,acetylation,methylation,and glycosylation,regulate osteogenic differentiation(OD).These modifications influence the expression of osteogenic genes by modulating the activity of key transcription factors like runt-related transcription factor 2 and osterix.While the molecular mechanisms behind OD are increasingly understood,many questions remain,particularly regarding how PTMs control the specificity and efficiency of stem cell differentiation.Recent research into these modifications has underscored the potential of stem cell therapy for bone regeneration and treating bone-related diseases.This review summarizes the role of PTMs in the OD of oral-derived stem cells,discusses their clinical applications,and suggests future research directions. 展开更多
关键词 Oral-derived stem cells Post-translational modifications Osteogenic differentiation Bone regeneration Signaling pathways Clinical translation
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Personalized translational medicine:Investigating YKL-40 as early biomarker for clinical risk stratification in hepatocellular carcinoma recurrence post-liver transplantation 认领 引用 被引量：1
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作者 Ileana Lulic Dinka Lulic +2 位作者 Jadranka Pavicic Saric Iva Bacak Kocman Dunja Rogic 《World Journal of Transplantation》 2025年第2期1-7,共7页
Hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)presents a significant challenge,with recurrence rates ranging from 8%to 20%globally.Current biomarkers,such as alpha-fetoprotein(AFP)and des-gamm... Hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)presents a significant challenge,with recurrence rates ranging from 8%to 20%globally.Current biomarkers,such as alpha-fetoprotein(AFP)and des-gamma-carboxy prothrombin(DCP),lack specificity,limiting their utility in risk strati-fication.YKL-40,a glycoprotein involved in extracellular matrix remodeling,hepatic stellate cell activation,and immune modulation,has emerged as a promising biomarker for post-LT surveillance.Elevated serum levels of YKL-40 are associated with advanced liver disease,tumor progression,and poorer post-LT outcomes,highlighting its potential to address gaps in early detection and personalized management of HCC recurrence.This manuscript synthesizes clinical and mechanistic evidence to evaluate YKL-40’s predictive utility in post-LT care.While preliminary findings demonstrate its specificity for liver-related pathologies,challenges remain,including assay standardization,lack of pro-spective validation,and the need to distinguish between malignant and non-malignant causes of elevated levels.Integrating YKL-40 into multi-biomarker panels with AFP and DCP could enhance predictive accuracy and enable tailored therapeutic strategies.Future research should focus on multicenter studies to validate YKL-40’s clinical utility,address confounding factors like graft rejection and systemic inflammation,and explore its role in predictive models driven by emerging technologies such as artificial intelligence.YKL-40 holds transformative potential in reshaping post-LT care through precision medicine,providing a pathway for better outcomes and improved management of high-risk LT recipients. 展开更多
关键词 Hepatocellular carcinoma recurrence Liver transplantation Personalized translational medicine Biomarkers YKL-40 Risk stratification
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The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast 认领 引用
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作者 Claudia Elizabeth Vera-Tizatl Arturo Vera-Hernández +4 位作者 Lorenzo Leija-Salas Marco Antonio Vega-López María del Carmen Ramírez-Estudillo German Isauro Garrido Fariña Adriana Leticia Vera-Tizatl 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第11期1997-2007,共11页
Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is... Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is highly comparable to that of humans and is histologically indistinguishable.Leveraging these advantages through the chemical induction of carcinogenesis in this model offers a robust approach to mimic human exposure to carcinogenic compounds.Methods:This study elaborates on a protocol for developing a representative model of MNU-induced invasive breast carcinoma in three Vietnamese swine,validated histologically and immunologically.It evaluates not only the tissue similarity with humans,but also the development of chemically induced mammary tumors in an immunologically competent animal.Moreover,this study addresses the existing gap in histological knowledge regarding mammary tissue in the porcine model.Results:Our findings suggest that this model encompasses the full spectrum of cancer.It incorporates the key elements of a tumor microenvironment that enable tumor growth and propagation,such as immune cells,blood vessels,fibroblasts,extracellular matrix,fatty acids,and signaling molecules.Conclusions:This model offers significant potential to advance the understanding of cancer pathogenesis and facilitate the development of innovative therapeutic strategies by closely replicating human tumor biology. 展开更多
关键词 breast cancer N-methyl-N-nitrosourea translational medicine Vietnamese swine
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Response of the Yellow and East China seas low-trophic ecosystems to two typhoons at different translational speeds 认领 引用
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作者 Lei ZHU Jing ZHANG +6 位作者 Changcen SHI Wei YANG Haiyan ZHANG Yucheng WANG Guangliang LIU Changwei BIAN Liang ZHAO 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2025年第5期1441-1461,共21页
Frequent typhoons can significantly change the temperature,nutrient availability,and phytoplankton biomass in marginal seas.The oceanic response to typhoons is usually influenced by the features of the typhoon,among w... Frequent typhoons can significantly change the temperature,nutrient availability,and phytoplankton biomass in marginal seas.The oceanic response to typhoons is usually influenced by the features of the typhoon,among which the translational speed is critically important.By using a high resolution coupled physical-biological model,we investigated the response of the Yellow and East China seas(YECS)to two typhoons at different translational speeds,Muifa in August 2011 and Bolaven in August 2012.The model well reproduced the spatial and temporal variations of temperature,chlorophyll-a concentration over the YECS.Results show that typhoons with slower translational speeds uplift more deep water,leading to a more significant oceanic response.Divergence and convergence caused nutrient fluxes in opposite directions in the surface and bottom layers.Moreover,the nutrient flux in the bottom layer was greater than that in the surface layer.These phenomena are closely related to the spatial distribution of nutrients.Further studies show that the degree of ocean response to typhoons is highly correlated with the initial conditions of physical and biological elements of the upper ocean before the typhoon,as well as with ocean structure.Pretyphoon initial conditions of oceanic physical and ecological elements,mixed layer depth,and potential energy anomalies can all alter the degree of typhoon-induced oceanic response.This study emphasizes the important roles of the translational speed of typhoons and the initial oceanic conditions in the oceanic response to typhoons. 展开更多
关键词 typhoon Yellow and East China seas(YECS) translational speed Ekman pumping
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Immune biomarkers as early indicators of renal damage in type 1 diabetic children: A step toward translational medicine 认领 引用
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作者 Jian-Wen Fan Su-Yi Xu +1 位作者 Jun Wu Yong-Wei Yu 《World Journal of Diabetes》 SCIE 2025年第6期357-361,共5页
An article recently published in the World Journal of Diabetes,provides valuable insights into using immune biomarkers to identify renal damage in pediatric patients with newly diagnosed type 1 diabetes(T1D).Although ... An article recently published in the World Journal of Diabetes,provides valuable insights into using immune biomarkers to identify renal damage in pediatric patients with newly diagnosed type 1 diabetes(T1D).Although these findings are promising,clinical translation of these immune markers into routine diagnostics and preventive care remains challenging.In this letter,we propose building on the authors’work by exploring the integration of immune biomarkers into a more comprehensive dynamic risk stratification model for early renal injury.Com-bining immune system indicators with metabolic and genetic factors could enhance the predictive accuracy and support more personalized interventions.Longitudinal studies are needed to evaluate temporal changes in immune biomarkers and their association with long-term renal outcomes in children with T1Ds.Immunomodulatory therapies targeting early immune dysfunction can prevent or slow the progression of diabetic nephropathy.By incorporating these aspects,we hope to translate immune biomarkers from research into practical clinical tools,ultimately improving patient outcomes and reducing the burden of kidney-related complications in pediatric diabetes. 展开更多
关键词 Type 1 diabetes Immune biomarkers Renal damage Risk stratification Translational medicine
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Advances in precision diagnosis and treatment,and translational medicine research for refractory relapsed multiple myeloma 认领 引用
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作者 Wei Fu Jun-Li Wang +2 位作者 Guo-Bin Cheng Lin-Ya Lyu Hu-Lin Wang 《Cancer Advances》 2025年第6期1-9,共9页
Multiple myeloma is a complex and challenging blood cancer,particularly in cases where the disease has relapsed or become resistant to treatment.These situations often have a significant impact on both patient surviva... Multiple myeloma is a complex and challenging blood cancer,particularly in cases where the disease has relapsed or become resistant to treatment.These situations often have a significant impact on both patient survival and quality of life.Over recent years,advances in precision medicine and translational medicine have brought about a shift in treatment strategies,moving toward more personalized and targeted approaches.This review highlights the latest developments in the management of refractory and relapsed multiple myeloma,focusing on the current state of precision diagnosis and treatment,the role of translational medicine,and potential future directions in research.By reviewing key studies and clinical trial data,we aim to offer fresh perspectives and strategies that could improve clinical outcomes. 展开更多
关键词 multiple myeloma refractory relapsed precision medicine translational medicine treatment strategies
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