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Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk:Key regulator of obesity pathophysiology and metabolic dysregulation 认领 引用
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作者 Ao-Yun Zhang Cong-Yi Xie +6 位作者 Xiao Song Zi-Han Guo Yu-Rou Shi Shuai-Yan Wang Guan-Hu Yang Yun Liu Tian-Cheng Xu 《World Journal of Biological Chemistry》 2026年第2期47-57,共11页
Obesity,a global epidemic,is closely linked to metabolic complications like insulin resistance and type 2 diabetes.Pancreatic dysfunction(impaired islet secretion and local inflammation)is central to this deterioratio... Obesity,a global epidemic,is closely linked to metabolic complications like insulin resistance and type 2 diabetes.Pancreatic dysfunction(impaired islet secretion and local inflammation)is central to this deterioration,yet the underlying mechanisms remain unclear.Pancreatic macrophages regulate tissue inflammation and metabolic homeostasis,but their context-specific polarization in obesity is undefined.This review discusses the role of triggering receptor expressed on myeloid cells 2(TREM2)in modulating pancreatic macrophage behavior in the context of obesity,based on findings from diet-induced obese mouse models and ex vivo pancreatic analyses.Emerging evidence indicates that TREM2 expression is markedly upregulated in pancreatic macrophages of obese subjects,where TREM2-driven macrophage activation promotes pro-inflammatory cytokine release and disrupts macrophage-islet β-cell crosstalk.Transcriptomic profiling reveals that TREM2 signaling reshapes macrophage transcriptional landscapes,enhancing proinflammatory phenotypes while impairing islet-supporting capacity.Notably,macrophage-specific TREM2 ablation has been shown to ameliorate pancreatic inflammation,restore islet insulin secretion,and alleviate systemic metabolic disorders in obese mice.Collectively,these findings identify TREM2 as a pivotal molecular switch governing pancreatic macrophage-mediated metabolic dysfunction in obesity,highlighting TREM2+pancreatic macrophages as a potential therapeutic target.These findings advance the understanding of immunemetabolic crosstalk in the pancreas,laying a foundation for developing novel immunometabolic interventions. 展开更多
关键词 Triggering receptor expressed on myeloid cells 2 Obesity Pancreatic macrophages Pancreatic inflammation Immunometabolism
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Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease 认领 引用 被引量：1
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作者 Li-Hui Zhang Su-Tong Liu +5 位作者 Qing Zhao Xiao-Yan Liu Tong Liu Qiang Zhang Ming-Hao Liu Wen-Xia Zhao 《World Journal of Hepatology》 2025年第2期31-46,共16页
Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellula... Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2. 展开更多
关键词 Triggering receptor expressed on myeloid cells 2 Non-alcoholic fatty liver disease Macrophage Lipid metabolism Inflammation
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Static Stress Triggering Effect on the Surrounding Major Faults and Aftershocks of the 2024 M 7.4 Earthquake in Hualien,Taiwan,China 认领 引用 被引量：1
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作者 Sheng Shu-Zhong Mi Zi-Fei +1 位作者 Zhang Xiao-Juan Ge Kun-Peng 《Applied Geophysics》 SCIE CSCD 2025年第2期511-522,560,561,共12页
Earthquakes not only release the long-term accumulated stress on the seismogenic fault but may also increase the stress on some surrounding faults or other segments of the seismogenic fault,thereby raising the seismic... Earthquakes not only release the long-term accumulated stress on the seismogenic fault but may also increase the stress on some surrounding faults or other segments of the seismogenic fault,thereby raising the seismic risk on these faults.This study investigates the impact of the April 2,2024,Mw 7.4 earthquake in Hualien,Taiwan,China,on the surrounding faults and aftershocks.We analyze stress-triggering effects by calculating Coulomb stress changes(ΔCFS)using rupture models and focal mechanism data.Historical focal mechanism nodal planes serve as receiver fault parameters forΔCFS calculations.Our findings indicate signifi cant Coulomb stress loading on the Longitudinal Valley fault and Central Range structure due to the mainshock,promoting their seismic activity.Loading effects vary by fault type,with thrust and strike-slip faults experiencing more stress loading than normal and odd faults.Conversely,the rupture’s coseismic slip concentration area shows predominant stress unloading,inhibiting seismic activity in the region.Aftershocks mainly experience increasedΔCFS,suggesting that the stress-triggering induced by the mainshock considerably influences the earthquake sequence evolution.These insights are crucial for understanding aftershock patterns and enhancing seismic hazard assessments. 展开更多
关键词 Taiwan,China The Hualien earthquake static stress triggering focal mechanism receiver fault aftershock
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Triggering Relationship between Mud Volcanoes and Seismicity:Implications from Offshore Southwest Taiwan,China 认领 引用 被引量：1
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作者 Gege Hui 《Journal of Earth Science》 SCIE CAS CSCD 2025年第3期960-974,共15页
The release of accumulated stress through earthquakes is known to devote to the mud volcanism occurrence,which may in turn affect subsequent regional seismicity.Mud volcanoes have been observed on the northeast contin... The release of accumulated stress through earthquakes is known to devote to the mud volcanism occurrence,which may in turn affect subsequent regional seismicity.Mud volcanoes have been observed on the northeast continental margin of the South China Sea as well.Based on the mud volcanoes and earthquakes catalogue,we measured the spatial and temporal distribution of z and b values,to explore the geodynamic process of the repeated eruptions of mud volcanoes influence on the regional seismicity.The results suggest a close correlation between the b-z values and mud volcanism occurrence in the SW Taiwan.Generally,the z-value anomalies in where the mud volcanoes eruptions show unchanged negative values and indicate seismic quiescence before a big earthquake,whereas the b-values often show periodicity fluctuations around the value of 0.5.This may indicate a mutual triggering relationship between the mud volcanoes and earthquakes.We infer that mud volcano eruptions help to partition and release part of the regional stress accumulation from the seismogenic structures,thus balancing the local stress and mitigating large-magnitude seismicity occurring probability. 展开更多
关键词 mud volcano SW Taiwan coulomb stress change b-z-value mutual triggering relationship earthquakes geodynamics
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Numerical investigation of dynamic response and rupture properties of rock slopes subjected to earthquake triggering 认领 引用 被引量：1
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作者 MA Ke JIANG Zhengchun +3 位作者 LIAO Zhiyi GAO Zhiliang WANG Longjiang KE Hu 《Journal of Mountain Science》 SCIE CSCD 2025年第2期710-728,共19页
Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain... Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain poorly understood.In this study,finite element method-based numerical simulations were conducted based on the rock slope at Dagangshan Hydropower Station in Sichuan province,China.Firstly,systematic analysis in both the time and frequency domains were performed to examine the seismic dynamic characteristics of the slope.Subsequently,the transfer function method and the multiple stepwise linear regression method were employed to clarify the underlying mechanism and determine critical factors influencing the slope instability during earthquakes.Time-domain analysis reveals that rock slope dynamic response exhibits notable elevation,surface,and local amplification effects.Specifically,the Peak Ground Acceleration(PGA)amplification coefficient(MPGA)is significantly higher at elevated locations,near the slope surface and in areas with protrusions.Moreover,the existence of fracture zones and anti-shear galleries minimally influences the dynamic responses but considerably affect the rupture.Specifically,fracture zones exacerbate rupture,while anti-shear galleries mitigate it.Frequency-domain analysis indicates that the dynamic responses of the slope are closely correlated with the degree of slope rupture.As earthquake magnitude increases,the rupture degree of the slope intensifies,and the dominant frequency of the response within the slope decreases,e.g.,its value shifts from 3.63 to 2.75 Hz at measurement point 9near the slope surface.The transfer function of rock slope,calculated under the excitation of wide flat spectrum white noise can reflect the interrelationships between the inherent properties and the rupture degree.Notably,the peak of the transfer function undergoes inversion as the degree of rupture increases.Furthermore,through multiple stepwise linear regression analysis,four key factors influencing the surface dynamic response of the slope were identified:rock strength,slope angle,elevation,and seismic dominant frequency.These findings provide valuable insights into the underlying mechanisms of rock slope dynamic responses triggered by earthquakes,offering essential guidance for understanding and mitigating seismic impacts on rock slopes. 展开更多
关键词 Numerical simulation Rock slope Earthquake trigger Dynamic response Rupture properties
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Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage 认领 引用 被引量：1
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作者 Fan Yi Hao Wu Hai-Kang Zhao 《World Journal of Clinical Cases》 2025年第9期1-12,共12页
Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially... Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially among patients with poor functional outcomes.ICH is often accompanied by decreased consciousness and limb dysfunction.This seriously affects patients’ability to live independently.Although rapid advances in neurosurgery have greatly improved patient survival,there remains insufficient evidence that surgical treatment significantly improves long-term outcomes.With in-depth pathophysiological studies after ICH,increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after ICH.In basic and clinical studies of various systemic inflammatory diseases,triggering receptor expressed on myeloid cells 1/2(TREM-1/2),and the TREM receptor family is closely related to the inflammatory response.Various inflammatory diseases can be upregulated and downregulated through receptor intervention.How the TREM receptor functions after ICH,the types of results from intervention,and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are unknown.An analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response,significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage,and thus improve the ability of patients to live independently. 展开更多
关键词 Cerebral hemorrhage Secondary injury Triggering receptor expressed on myeloid cells 1/2 Neurosurgery Inflammatory response
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Possible triggering relationship of six Mw > 6 earthquakes in 2018–2019 at Philippine archipelago 认领 引用
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作者 Qiu Zhong Yangfan Deng +1 位作者 Zhigang Peng Lingyuan Meng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2021年第7期142-158,共17页
Philippine archipelago (PA) has strong background seismicity,but there is no systematic study of earthquake triggering in this region. There are six earthquakes (Mw > 6) occurred between 2018/12/29 and 2019/09/2... Philippine archipelago (PA) has strong background seismicity,but there is no systematic study of earthquake triggering in this region. There are six earthquakes (Mw > 6) occurred between 2018/12/29 and 2019/09/29 in PA,which provides an excellent opportunity to investigate the triggering relationship among these events. We calculate the static Coulomb stress changes of the first five events,and find that the local seismicity after the 2018/12/29 Mw 7.0 earthquake is mostly associated with positive Coulomb stress changes,including the 2019/05/31 Mw 6.1 event,suggesting a possible triggering relationship. However,we cannot rule out the dynamic triggering mechanism,due to increased microseismicity in both positive and negative stress change regions,and an incomplete local catalog,especially right after the first Mw 7.0 mainshock. The dynamic stresses from these Mw > 6 events are large enough (from 5 kPa to 3532 kPa) to trigger subsequent events,but a lack of seismicity and waveform evidence does not support delayed dynamic triggering among these events,even the shortest time interval is less than 24 hours. In the past 45 years,the released seismic energy shows certain peaks every 5–10 years. However,earthquakes with Mw > 6.0 were relatively infrequent between 2004 and 2018 at PA. Hence,it is possible that several regions are relatively late in their earthquake cycles,which would enhance their susceptibility of being triggered by earthquakes at nearby and regional distances. 展开更多
关键词 static triggering dynamic triggering seismicity ETAS model Philippine archipelago
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Research on seismic stress triggering 认领 引用
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作者 万永革 吴忠良 +2 位作者 周公威 黄静 秦立新 《Acta Seismologica Sinica(English Edition)》 2002年第5期559-577,共19页
This paper briefly reviews basic theory of seismic stress triggering. Recent development on seismic stress triggering has been reviewed in the views of seismic static and dynamic stress triggering, application of visc... This paper briefly reviews basic theory of seismic stress triggering. Recent development on seismic stress triggering has been reviewed in the views of seismic static and dynamic stress triggering, application of viscoelastic model in seismic stress triggering, the relation between earthquake triggering and volcanic eruption or explosion, other explanation of earthquake triggering, etc. And some suggestions for further study on seismic stress triggering in near future are given. 展开更多
关键词 Coulomb failure stress change seismic static stress triggering seismic dynamic stress triggering viscoelastic medium
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Avalanche activity and characteristics of its triggering factors in the western Tianshan Mountains,China 认领 引用 被引量：22
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作者 HAO Jian-sheng HUANG Fa-rong +2 位作者 LIU Yang Amobichukwu Chukwudi AMANAMBU LI Lan-hai 《Journal of Mountain Science》 SCIE CSCD 2018年第7期1397-1411,共15页
Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the... Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the characteristics of triggering factors for avalanche activity in this region to improve road safety and the management of natural hazards. Based on the observation of avalanche activity along the national road G218 in the western Tianshan Mountains, avalanche event data in combination with meteorological, snowpack and earthquake data were collected and analyzed. The snow climate of the mountain range was examined using a recently developed snow climate classification scheme, and triggering conditions of snow avalanche in different snow climate regions were compared. The results show that snowfall is the most common triggering factor for a natural avalanche and there is high probability of avalanche release with snowfall exceeding 20.4 mm during a snowfall period. Consecutive rise in temperature within three days and daily mean temperature reaching 0.5℃ in the following day imply a high probability of temperaturerise-triggered avalanche release. Earthquakes have a significant impact on the formation of large size avalanches in the area. For the period 2011-2017, five cases were identified as a consequence of earthquake with magnitudes of 3.3≤M_L≤5.1 and source-to-site distances of 19~139 km. The Tianshan Mountains are characterized by a continental snow climate with lower snow density, lower snow shear strength and high proportion depth hoar, which explains that both the snowfall and temperature for triggering avalanche release in the continental snow climate of the Tianshan Mountains are lower than that in maritime snow climate and transitional snow climate regions. The findings help forecast avalanche release for mitigating avalanche disaster and assessing the risk of avalanche disaster. 展开更多
关键词 Snow avalanche Snow properties Snow climate Triggering conditions Risk management
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Mechanisms involved in triggering debris flows,within a cohesive gravel soil mass on a slope:a case in SW China 认领 引用 被引量：7
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作者 CHEN Ning-sheng ZHU Yun-hua +3 位作者 HUANG Qi IQBAL Javed DENG Ming-feng HE Na 《Journal of Mountain Science》 SCIE CSCD 2017年第4期611-620,共10页
The triggering mechanisms of debris flows were explored in the field using artificial rainfall experiments in two gullies, Dawazi Gully and Aizi Gully, in Yunnan and Sichuan Provinces, China,respectively. The soils at... The triggering mechanisms of debris flows were explored in the field using artificial rainfall experiments in two gullies, Dawazi Gully and Aizi Gully, in Yunnan and Sichuan Provinces, China,respectively. The soils at both sites are bare, loose and cohesive gravel-dominated. The results of a direct shear test, rheological test and back-analysis using soil mass stability calculations indicate that the mechanisms responsible for triggering debris flows involved the decreases in static and dynamic resistance of the soil. The triggering processes can be divided into 7 stages: rainfall infiltration, generation of excess runoff, high pore water pressure, surface erosion, soil creep, soil slipping, debris flow triggering and debris flow increment. In addition, two critical steps are evident:(i) During the process of the soil mass changing from a static to a mobile state, its cohesion decreased sharply(e.g., the cohesion of the soil mass in Dawazi Gully decreased from 0.520 to0.090 k Pa, a decrease of 83%). This would have reduced the soil strength and the kinetic energy during slipping, eventually triggered the debris flow.(ii) When the soil mass began to slip, the velocity and the volume increment of the debris flow fluctuated as a result of the interaction of soil resistance and the sliding force. The displaced soil mass from the source area of the slope resulted in the deposition of a volume of soil more than 7-8 times greater than that in the source area. 展开更多
关键词 Debris flow Cohesive gravel soil Triggering mechanism Slip Soil erosion
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Spatiotemporal deformation characteristics of Outang landslide and identification of triggering factors using data mining 认领 引用 被引量：7
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作者 Beibei Yang Zhongqiang Liu +1 位作者 Suzanne Lacasse Xin Liang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4088-4104,共17页
Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landsli... Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas. 展开更多
关键词 Landslide Deformation characteristics Triggering factor Data mining Three gorges reservoir
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Comparison of Production-Triggering Strategies for Manufacturing Enterprises under Random Orders 认领 引用 被引量：4
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作者 Longfei Zhou Lin Zhang Yajun Fang 《Engineering》 SCIE EI CAS CSCD 2021年第6期798-806,共9页
Although new technologies have been deeply applied in manufacturing systems,manufacturing enterprises are still encountering difficulties in maintaining efficient and flexible production due to the random arrivals of ... Although new technologies have been deeply applied in manufacturing systems,manufacturing enterprises are still encountering difficulties in maintaining efficient and flexible production due to the random arrivals of diverse customer requirements.Fast order delivery and low inventory cost are fundamentally contradictory to each other.How to make a suitable production-triggering strategy is a critical issue for an enterprise to maintain a high level of competitiveness in a dynamic environment.In this paper,we focus on production-triggering strategies for manufacturing enterprises to satisfy randomly arriving orders and reduce inventory costs.Unified theoretical models and simulation models of different production strategies are proposed,including time-triggered strategies,event-triggered strategies,and hybrid-triggered strategies.In each model,both part-production-triggering strategies and product-assembly-triggering strategies are considered and implemented.The time-triggered models and hybrid-triggered models also consider the impact of the period on system performance.The results show that hybrid-triggered and time-triggered strategies yield faster order delivery and lower inventory costs than event-triggered strategies if the period is set appropriately. 展开更多
关键词 Collaborative manufacturing Production triggering Optimization Simulation Enterprise
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Electrical triggering of earthquakes:results of laboratory experiments at spring-block models 认领 引用 被引量：3
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作者 Victor A.Novikov Vladimir I.Okunev +3 位作者 Vadim N.Klyuchkin Jing Liu Yuri Ya.Ruzhin Xuhui Shen 《Earthquake Science》 CSCD 2017年第4期167-172,共6页
Recently published results of field and laboratory experiments on the seismic/acoustic response to injection of direct current （DC） pulses into the Earth crust or stressed rock samples raised a question on a possibi... Recently published results of field and laboratory experiments on the seismic/acoustic response to injection of direct current （DC） pulses into the Earth crust or stressed rock samples raised a question on a possibility of electrical earthquake triggering. A physical mechanism of the considered phenomenon is not clear yet in view of the very low current density （10-7-10-s A/m^2） generated by the pulsed power systems at the epicenter depth （5-10 km） of local earthquakes occurred just after the current injection. The paper describes results of laboratory ＂earthquake＂ triggering by DC pulses under conditions of a spring-block model simulated the seismogenic fault. It is experimentally shown that the electric triggering of the laboratory ＂earthquake＂ （sharp slip of a movable block of the spring-block system） is possible only within a range of subcritical state of the system, when the shear stress between the movable and fixed blocks obtains 0.98-0.99 of its critical value. The threshold of electric triggering action is about 20 A/m^2 that is 7-8 orders of magnitude higher than estimated electric current density for Bishkek test site （Northern Tien Shan, Kirghizia） where the seismic response to the man-made electric action was observed. In this connection, the electric triggering phenomena may be explained by contraction of electric current in the narrow conductive areas of the faults and the corresponding increase in current density or by involving the secondary triggering mechanisms like electromagnetic stimulation of conductive fluid migration into the fault area resulted in decrease in the fault strength properties. 展开更多
关键词 Earthquake simulation Spring-block model Electric pulse Triggering threshold
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Static Stress Triggering Effects Related with M_s8.0 Wenchuan Earthquake 认领 引用 被引量：11
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作者 朱航 闻学泽 《Journal of Earth Science》 SCIE CAS 2010年第1期32-41,共10页
In this article, firstly, we calculated and analyzed the patterns of Coulomb stress changes induced by a sequence of strong earthquakes that occurred in Songpan （松藩）, Sichuan （四川） Province in 1973 and 1976, an... In this article, firstly, we calculated and analyzed the patterns of Coulomb stress changes induced by a sequence of strong earthquakes that occurred in Songpan （松藩）, Sichuan （四川） Province in 1973 and 1976, and discovered that the Ms8.0 Wenchuan （汶川） earthquake of 2008 was epicentered in a relevant Coulomb stress triggering zone. This suggests that the Coulomb stress on the middle and southern segments of the Longmenshan （龙门山） fault zone increased after the Songpan sequence of strong earthquakes, and the stress increment might cause the 2008 Wenchuan earthquake having al- ready occurred somewhat ahead of time. Further, we calculated and analyzed Coulomb stress changes coinduced by both the Songpan sequence and the Ms8.0 Wenchuan mainshock. The result shows that the Ms6.4 Qingchuan （青川） earthquake of May 25, 2008 on the northeastern segment of the Longmenshan fault zone was triggered by the Wenchuan mainshock, and that the southwestern segment of the fault zone is also in the stress triggering zone. Besides, the Maoxian （茂县）-Wenchuan fault （i.e., the back-range fault of the Longmenshan fault zone）, which extends parallel to the seismogenic fault of the Wenchuan earthquake, is in a shadow zone of the Coulomb stress changes, and therefore, its potential hazard for producing a strong or large earthquake in the near future could be reduced relatively. 展开更多
关键词 2008 Wenchuan earthquake Songpan strong earthquake sequence static stress triggering Coulomb failure stress change seismic hazard.
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Stress triggering effect on the 2022 Honghe MS5.0 earthquake with historical strong earthquakes 认领 引用 被引量：4
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作者 Mingce Wang Zifeng Liu Ruijie Luo 《Geodesy and Geodynamics》 EI CSCD 2024年第2期107-113,共7页
The 2022 Honghe MS5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than MS5.0.To elucidate the seismogenic mechani... The 2022 Honghe MS5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than MS5.0.To elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 bar.Noteworthy seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe earthquake.Areas of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang faults.Additionally,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings. 展开更多
关键词 Honghe Ms5.0 earthquake Coulomb failurestress Stress triggering Historical strongearthquakes
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Triggering mechanism and dynamic process of water-rock flow in Nanfen waste dump in 2010 认领 引用 被引量：3
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作者 CAO Chun-hui FENG Ji-li TAO Zhi-gang 《Journal of Mountain Science》 SCIE CSCD 2021年第10期2565-2579,共15页
Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mi... Water-rock flow is a kind of debris flow with more coarse particles and low viscosity, which occurs in many areas of the world. In this work, the water-rock flow that occurred on May 24, 2010, at Nanfen’s open-pit mine of China was investigated by combining field investigation, meteorological and hydrological survey with numerical simulation to understand its triggering mechanism and dynamic process. The field data shows that the short-term high-intensity rainfall is the most direct inducement to trigger water-rock flow in the waste dump. The loose shallow gravel soil and the V-shaped valley with a certain slope provide the necessary conditions of the occurrence of water-rock flow in the waste dump. Moreover, the possibility criterion of water-rock flow is presented by analyzing the historical rainfall data. In addition, the smoothed particle hydrodynamics(SPH) method was employed to simulate the waterrock flow under the conditions of Newtonian fluid with uniform distribution of water and coarse-grained materials. The simulating results show that the flow distance, velocity, shape, and deposition profile of water-rock flow are in good agreement with the field observation. The present work is beneficial to the risk assessment and mitigation design of water-rock flow disaster in the waste dump. 展开更多
关键词 Water-rock flow Waste dump Triggering mechanism Smoothed particle hydrodynamics Rainfall intensity
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Stress triggering of the Lushan M7. 0 earthquake by the Wenchuan Ms8. 0 earthquake 认领 引用 被引量：3
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作者 Wu Jianchao Yu Song +2 位作者 Cai Yongjian Lei Dongning Li Heng 《Geodesy and Geodynamics》 2013年第3期35-39,共5页
The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the We... The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt, respectively. Based on the focal mechanism and finite fault model of the Wenchuan Ms8.0 earthquake, we calculated the coulomb failure stress change. The inverted coulomb stress changes based on the Nishimura and Chenji models both show that the Lushan MT. 0 earth- quake occurred in the increased area of coulomb failure stress induced by the Wenchuan Ms8. 0 earthquake. The coulomb failure stress increased by approximately 0. 135 - 0. 152 bar in the source of the Lushan M7.0 earthquake, which is far more than the stress triggering threshold. Therefore, the Lushan M7.0 earthquake was most likely triggered by the coulomb failure stress change. 展开更多
关键词 focal mechanism finite fault model coulomb failure stress stress triggering threshold
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Seismic stress perturbation and triggering patterns induced by the 2016 Central Italy earthquake sequences 认领 引用 被引量：1
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作者 ZHANG Lu-peng HUANG Ding-fa +2 位作者 JIANG Zhong-shan FENG Wei HASSAN Abubakr 《Journal of Mountain Science》 SCIE CSCD 2021年第6期1424-1438,共15页
Numerous shallow earthquakes, including 24 th August Amatrice, 26 th October Visso, and 30 th October Norcia earthquakes, ruptured the segments of Mount Vettore-Gorzano fault system in the central Apennines(Italy) in ... Numerous shallow earthquakes, including 24 th August Amatrice, 26 th October Visso, and 30 th October Norcia earthquakes, ruptured the segments of Mount Vettore-Gorzano fault system in the central Apennines(Italy) in 2016. In order to investigate the stress perturbation and triggering patterns among the earthquake sequences, we introduce a more realistic nonplanar coseismic fault geometry model, which improve the rupture model by assimilating relocated aftershocks and the GPS observations. We adopt the seismic slip inversion program of the steepest descent method(SDM) to create the detailed coseismic rupture models and optimize Coulomb Failure Stress model by varying the coefficient of friction and received fault parameters. The results indicate that the nonplanar fault geometry model is more reflective of the deep slip of the coseismic rupture than planar model. As evidenced by the coseismic Coulomb stress changes caused by the three mainshocks at different depth slices, the stress loading mainly distributes on the active fault zones and the stress changes can well explain the spatial distribution of aftershocks. The first large Amatrice mainshock accelerates the occurrence of the Mw 5.9 Visso and Mw 6.6 Norcia earthquakes, with the positive stress changes at the hypocenter exceeding the stress triggering threshold(0.010×106 Pa) and up to 0.015×106 and 0.257×106 Pa, respectively. Furthermore, the Mw 5.9 Visso earthquake as well encourages the occurrence of the Mw 6.6 Norcia event with the increased stress changes of 0.052×106 Pa on the hypocenter. It is concluded that the stress transfer and accumulation play crucial roles on the linkage triggering mechanism among the mainshock-mainshock and mainshockaftershocks. Noteworthily, the cumulative stress changes on the southwest segment of the Norcia Fault(NF), the southeast parts of the Montereale Fault System(MFS) and Mount Gorzano Fault(MGF) of the main regions are up to(1.5~3.5) ×106 Pa. The cumulative stress changes have not been released sufficiently by aftershocks, which may increase the seismic hazard in those regions. 展开更多
关键词 GPS Relocated aftershocks Nonplanar fault geometry Stress perturbation Seismic triggering patterns Seismic risk assessment
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Expression of triggering receptor-1 in myeloid cells of mice with acute lung injury 认领 引用 被引量：2
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作者 Ning Liu Qin Gu Yi-shan Zheng 《World Journal of Emergency Medicine》 CAS 2010年第2期144-148,共5页
BACKGROUND:Myeloid cell(TREM-1)is an important mediator of the signal transduction pathway in inflammatory response.In this study,a mouse model of acute lung injury(ALl)by intraperitoneal injection of lipopolysacchari... BACKGROUND:Myeloid cell(TREM-1)is an important mediator of the signal transduction pathway in inflammatory response.In this study,a mouse model of acute lung injury(ALl)by intraperitoneal injection of lipopolysaccharide(LPS)was established to observe the expression pattern of TREM-1 in lung tissue and the role of TREM-1 in pulmonary inflammatory response to ALl.METHODS:Thirty BALB/C mice were randomly divided into a normal control group(n=6)and an ALl group(n=24).The model of ALl was made by intraperitonal injection of LPS in dose of 10 mg/kg.Specimens from peripheral blood and lung tissue were collected 6,12,24 and 48 hours after LPS injection.RT-PCR was used to detect TREM-1 mRNA,and ELISA was employed for detection of TREM-1 protein and TNF-a protein,and HE staining was performed for the pathological Smith lung scoring under a light microscope.RESULTS:The expressions of TREM-1 mRNAin lung tissue and blood of the ALl group 6,12,24,and 48 hours after injection of LPS were higher than those in the control group.The levels of TREM-1 protein and the levels of TNF-a protein in lung tissue of the ALl group 6,12,24,and 48 hours after LPS injection were higher than those of the control group;the level of TREM-1 protein peaked 12 hours after LPS injection,but it was not significantly correlated with the expression of TREM-1 mRNA(P=0.14);the TNF-a concentration was positively correlated with TREM-1 levels in lung tissue and with Smith pathological score(r=0.795,P=0.001:r=0.499,P=0.034),but not with the expression of TREM-1 mRNA(P=0.176).CONCLUSION:The expression of TREM-1 mRNA in lung tissue of mice with ALl is elevated,and the expression of TREM-1 mRNA is related to the level of TNF-a and the severity of inflammatory response to ALl.The expressions of the TREM-1 gene are not consistent with the levels of TREM-1 protein,suggesting a new functional protein involved in immune regulation. 展开更多
关键词 Acute lung injury Triggering receptor-1 Myeloid cell Expression Tumor necrosis factor Pathological scoring
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Characteristics and triggering mechanisms of early negative Indian Ocean Dipole 认领 引用 被引量：1
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作者 Yue Fang Shuangwen Sun +2 位作者 Yongcan Zu Jianhu Wang Lin Feng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第3期59-65,共7页
Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in... Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related nIOD.However,the characteristics and triggering mechanisms of early nIOD are unclear.Our results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six decades.These two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal cycles.The early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related nIOD.The spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian Ocean.Opposite to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon onset.The results of this study are helpful for improving the prediction skill of IOD and its climate impacts. 展开更多
关键词 Indian Ocean Dipole(IOD) triggering mechanism Indian summer monsoon seasonal cycle negative IOD
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