Intergrown ferromanganese ore resources are typical strategic mineral resources with huge reserves and abundant hematite,pyrolusite,and other valuable minerals,which is of great significance for its development and ut...Intergrown ferromanganese ore resources are typical strategic mineral resources with huge reserves and abundant hematite,pyrolusite,and other valuable minerals,which is of great significance for its development and utilization.This paper adopts a combination of phase transformation and magnetic separation to explore the phase transformation mechanism of Fe minerals and Mn minerals during the roasting process.The analysis of the properties of the raw ore shows that the Fe-containing and Mn-containing minerals of the intergrown ferromanganese ore are hematite and pyrolusite,respectively.The optimal conditions for controlling the mineral phase were obtained,including roasting temperature of 600℃ for 30 min,and a grinding fineness of<0.074 mm accounting for 50%.Meanwhile,a Fe grade of 61.05% with a recovery of 80.77%,and a Mn grade of 61.60% with a recovery of 87.81% were acquired.The precise mineral phase transformation(MPT)could be realized via adjusting the roasting conditions.Hematite is transformed into magnetite,while pyrolusite is transformed into manganosite,and then they were effectively separated and concentrated via magnetic separation.展开更多
Red mud is an alkaline solid waste generated by the alumina industry.Its annual global emissions have exceeded 180 million tons,and its prolonged open storage is prone to causing soil alkalization and air pollution.Re...Red mud is an alkaline solid waste generated by the alumina industry.Its annual global emissions have exceeded 180 million tons,and its prolonged open storage is prone to causing soil alkalization and air pollution.Red mud is considered to be a potential secondary resource given its rich valuable metal content.To realize the efficient resource utilization of red mud and convert solid waste into useful resources as much as possible,related researchers have carried out various studies on the recovery of iron from red mud.The relevant literature in recent years was summarized and analyzed.The research progress of iron resource recovery technology from red mud and the resource utilization of its tailings were also reviewed.In terms of iron recovery technologies,the process principles,technical characteristics,and limitations of these technologies for traditional methods such as physical sorting,pyrometallurgy,and hydrometallurgy,as well as emerging technologies including bioleaching,biomass pyrolysis reduction,and electrochemistry,are highlighted.A comparative analysis of the applicability of various technologies provides theoretical support for the selection of iron recovery processes under different conditions.At the same time,for the characteristics of the tailings produced after iron extraction from red mud,the ways of resource utilization in the fields of building materials and cementitious materials are discussed in depth,so as to realize the efficient utilization of the components of red mud.Finally,based on the research results obtained above and the current problems of red mud resource utilization,the sustainable development direction of red mud resource utilization in the future is prospected.展开更多
Compressed carbon dioxide(CO2)energy storage(CCES)has emerged as a promising large-scale energy storage technology,characterized by high energy density,moderate critical temperature,and operational flexibility.Conc...Compressed carbon dioxide(CO2)energy storage(CCES)has emerged as a promising large-scale energy storage technology,characterized by high energy density,moderate critical temperature,and operational flexibility.Concurrently,carbon capture,utilization and storage(CCUS)technology represents a critical pathway toward carbon neutrality for energy systems.The integration of CCES with CCUS is attracting growing research interests due to its unique potential to synergize energy and carbon flows within a closed-loop framework.This paper provides a comprehensive literature review of technological advancements in CCES and offers a perspective on its integration with CCUS.First,the fundamental working principle,system configurations,key performance indicators,and emerging demonstration projects of CCES are introduced.Subsequently,cutting-edge research and key challenges of CCES system are reviewed,focusing on optimization of CO2-based mixed working media,efficient liquefaction of low-pressure CO2,development of low-cost and safe CO2 storage facilities,enhancement of system performance through integration,and evaluation of dynamic behaviors.A central focus is placed on the integration of CCES with CCUS,highlighting how this synergy transforms CCES from a pure storage technology into a multi-functional tool for carbon management.This integration enables infrastructure sharing,dual-function storage(for energy and CO2),and improved economics.Finally,this review identifies key directions for future research,including advancing efficient system integration,developing high-precision transient simulation models and dynamic control algorithms,ensuring long-term safety of geological reservoirs under cyclic injectionextraction operations,and establishing multi-objective optimization and multicriteria assessment frameworks to support the commercial deployment of integrated CCES-CCUS systems.展开更多
The comprehensive pattern of the natural environment constitutes a complex system shaped by interactions among multiple natural elements,including geology,terrain,climate,hydrology,soil,and biodiversity.The regional s...The comprehensive pattern of the natural environment constitutes a complex system shaped by interactions among multiple natural elements,including geology,terrain,climate,hydrology,soil,and biodiversity.The regional structure that embodies this complexity is defined as the comprehensive natural terrestrial system.Consequently,this system provides an integrated perspective for understanding the overall characteristics of the natural environment and resources.Pakistan,with agriculture as its core economic sector,has a natural environment that is inherently linked to its topographic and climatic conditions.Its geographical environmental conditions are similar to those of China.Through analysis of Pakistan's geological,geomorphological,climatological,hydrological,and vegetation conditions,we adopted the methodology of China's comprehensive natural regionalization to establish a comprehensive natural terrestrial system scheme for Pakistan.Hierarchically,this scheme is divided into 3 major regions,5 temperature zones,8 humidity areas,and 23 natural regions.The scheme reveals the diversity of Pakistan's natural environment and its three-dimensional geographical zonality characteristics.Furthermore,this study analyzes the ecological advantages,constraints,and resource development potential of each regional unit and proposes targeted strategies for ecological conservation and socioeconomic development.The scheme provides a scientific basis for the sustainable socioeconomic development of Pakistan.展开更多
The role of organic carbon source as electron donor in incomplete denitrification,particularly in nitrite(NO2−)accumulation,remains crucial yet poorly understood.A detailed understanding of carbon and nitrogen m...The role of organic carbon source as electron donor in incomplete denitrification,particularly in nitrite(NO2−)accumulation,remains crucial yet poorly understood.A detailed understanding of carbon and nitrogen metabolic interactions is essential for advancing technologies that integrate partial denitrification(PD)with anammox.In this study,the carbon transformation and gradient utilization of various volatile fatty acids(VFAs)were explored to elucidate their impacts on nitrate(NO3−)and NO2−reduction during PD.Long-term experiments revealed that composite VFAs(a mixture of acetate,propionate and butyrate)achieved the highest nitrate-to-nitrite transformation ratio(NTR)of 79.1%,outperforming single VFA(69.5%with acetate and 69.4%with propionate).The NO2−accumulation during PD was strongly influenced by the utilization of exogenous,endogenous and extracellular carbon,which varied significantly with VFAs type and dosage.Polyhydroxybutyrate(PHB)served as the primary endogenous electron donor in acetate-driven PD,promoting modest NO2−accumulation,while polyhydroxyvalerate(PHV)along with glycogen(Gly)was the key contributor in propionate-driven PD,supporting complete NO3−reduction.In contrast to single VFA-driven PD,the lower levels and delayed utilization of PHB and PHV in composite VFAs-driven PD enabled more stable and efficient NO2−accumulation.Furthermore,metagenomic analysis illuminated that the transition from single VFA to composite VFAs strengthened the potential for both electron production and their transport to NO3−reductase.Thauera was always the core denitrifier demonstrating strong adaptability to various VFAs.This study provides mechanistic insights into organic carbon-regulated NO2−accumulation,filling the gap regarding dynamic changes in carbon utilization during PD.展开更多
The utilization of water-cooled electric furnace ferronickel slag(EFFS)in concrete remains constrained by its intrinsically low pozzolanic reactivity as a supplementary cementitious material(SCM)and its inadequate vol...The utilization of water-cooled electric furnace ferronickel slag(EFFS)in concrete remains constrained by its intrinsically low pozzolanic reactivity as a supplementary cementitious material(SCM)and its inadequate volumetric stability when employed as aggregate.This study systematically investigates the compositional characteristics of this slag across different particle-size fractions and proposes a wet-grinding activation strategy to enhance its pozzolanic performance.In particular,cement pastes incorporating 10%,30%,and 50%ultrafine EFFS derived from three original size fractions are comprehensively evaluated in terms of rheological behavior,compressive strength,hydration characteristics,and microstructural evolution.The results demonstrate pronounced size-dependent differences in phase composition.The amorphous phase content of EFFS particles smaller than 1.0 mm(EFFS0)reaches 54.04%,which is 19.72%higher than that of particles larger than 1.8 mm(EFFS2).The higher amorphous content leads to enhanced pozzolanic activity and improved mechanical performance.Mortars containing 30%ultrafine EFFS0 exhibit favorable strength development,with the 28-day compressive strength reaching 96%of that of the plain cement control and showing a 29%increase relative to the corresponding EFFS2 mixture.Based on these findings,a graded utilization strategy for water-cooled EFFS is proposed:The finer and more reactive fractions are suitable for SCM applications after activation,whereas the coarser fractions are more appropriate for non-cementitious applications,such as aggregate utilization.展开更多
Liver transplantation(LT)faces persistent organ shortages driving innovations like split liver transplantation(SLT),domino liver transplantation(DLT)and auxiliary liver transplantation(ALT).SLT emerges as a transforma...Liver transplantation(LT)faces persistent organ shortages driving innovations like split liver transplantation(SLT),domino liver transplantation(DLT)and auxiliary liver transplantation(ALT).SLT emerges as a transformative approach,enabling the transplantation of a solitary donor liver into two beneficiaries-a pediatric and an adult,an undertaking that curbs waiting list mortality rates for both demographics(1).Complementing this breakthrough,the advent of DLT permits the utilization of a liver from one transplant recipient as the donor organ for another patient,effectively facilitating the transplantation of two recipients using a“conventional”donor(2).ALT was initially used as the treatment for reversible fulminant liver failure(3).ALT has also been reported to have effective and long-term favorable results in patients with noncirrhotic metabolic liver disease and chronic cirrhotic liver disease(4,5).By amalgamating diverse transplantation methodologies,these advances serve to mitigate the organ shortage conundrum and,consequently,abate mortality on the transplant waiting list.Remarkably,we report an innovative clinical practice of LT encompassing three techniques:SLT,DLT,and ALT.These combined techniques materialize a remarkable achievement,wherein a single donor liver breathes life into three patients afflicted by end-stage liver disease,including one patient with massive liver cancer.展开更多
Brittleness Index(BI),while not universally standardized,is one of the most critical parameters in the assessment of rock failure behavior,drillability,and excavation efficiency in mining;however,its applicability to ...Brittleness Index(BI),while not universally standardized,is one of the most critical parameters in the assessment of rock failure behavior,drillability,and excavation efficiency in mining;however,its applicability to extraterrestrial environments remains poorly constrained for the In-Situ Resource Utilization(ISRU)mission on Mars.This study qualitatively and quantitatively investigated the mechanistic attributes(compressive strength,σc;tensile strength,σt)and BI of simulated Martian rocks under distinct conditions.Martian analog rock specimens,developed using Mars Global Simulant,were subjected to controlled bulk-scale mechanical tests(uniaxial compression and Brazilian disc tests)to determineσcandσt,supported by SEM-EDS analyses,to validate mineralogical similarity with Martian samples.Results revealed that the simulated Martian rocks are representative of Jezero crater lithologies and exhibit behavior characterized by linear elastic deformation followed by abrupt failure under stress.A gravity-modified brittleness index(BIM1,BIM2,BIM3,and BIM4)was proposed,which yielded lower brittleness thresholds consistent with a mechanically weaker Martian lithosphere.Further,the Martian-specific brittleness classification indicated that the analog Martian rocks fall predominantly within low-tomoderately brittle categories(0.1<BIM4<9.3)under Martian conditions,suggesting favorable drillability and relatively low energy requirements for excavation.These findings offer novel insights into the feasibility of predicting Martian excavation performance for ISRU.展开更多
CO2 capture and utilization(CCU)technologies have been recognized as crucial strategies for mitigating global warming,reducing carbon emission,and promoting resource circularity.As such,the design and development o...CO2 capture and utilization(CCU)technologies have been recognized as crucial strategies for mitigating global warming,reducing carbon emission,and promoting resource circularity.As such,the design and development of related materials have attracted considerable research attention.Carbon-based materials,characterized by tunable pore structures,abundant active sites,high specific surface area,and excellent chemical stability,demonstrate significant potential for applications in CO2 capture and utilization.This review systematically analyzes the adsorption behaviors and performance variations of typical carbon materials,including activated carbon,porous carbon,graphene,and carbon nanotubes during CO2 capture processes.Concerning CO2 utilization,emphasis is placed on recent advances in the catalytic applications of carbon-based materials in key reactions such as methanation,reverse water-gas shift,dry reforming of methane,and alcohol synthesis.Moreover,the benefits and drawbacks of carbon materials in terms of CO2 adsorption capacity,catalytic activity,and stability are thoroughly evaluated,and their potential applications in integrated CO2 capture and utilization technologies are discussed.Finally,key strategies for enhancing the performance of carbonaceous materials through structural modulation and surface modification are elucidated.This review aims to provide theoretical guidance for the future development and large-scale implementation of carbon-based materials in CCU technologies.展开更多
In view of the problems such as the low utilization efficiency of copper tailings solid waste,which leads to severe environmental pollution,and the easy combustibility of rigid polyurethane foam(RPUF)along with the ge...In view of the problems such as the low utilization efficiency of copper tailings solid waste,which leads to severe environmental pollution,and the easy combustibility of rigid polyurethane foam(RPUF)along with the generation of a large amount of toxic smoke during combustion,copper tailings were combined with melamine polyphosphate to prepare RPUF composites.The flame-retardant properties were investigated,and the structure–property relationship was clarified.It was found that when 16.7 g of copper tailings and 33.3 g of melamine polyphosphate were added,the limiting oxygen index increased to 23.0 vol.%,and the vertical burning rating(UL-94)reached V-0.The peak heat release rate was reduced by 27.79%compared to pure RPUF,and the fire growth index decreased to 4.54 kW/(m2s),representing a 75.42%reduction.The char residue rate at 750℃ increased from 17.6% to 28.51%.Moreover,the addition of copper tailings and melamine polyphosphate effectively promoted the charring of RPUF,forming a dense char layer with good fire resistance performance.展开更多
Targeting Chang'E-8 mission'in-situ resource utilization(ISRU)for sustainable lunar habitats,laser powder bed fusion(LPBF)provides a viable pathway for in-situ additive manufacturing of lunar regolith.To eluci...Targeting Chang'E-8 mission'in-situ resource utilization(ISRU)for sustainable lunar habitats,laser powder bed fusion(LPBF)provides a viable pathway for in-situ additive manufacturing of lunar regolith.To elucidate mission relevant mechanical behavior and failure mechanisms of LPBF fabricated lunar regolith simulants,mare type and highland type simulant specimens were produced.Microstructural characterization,mechanical test coupled with three-dimensional digital image correlation(3D-DIC),and an energy-dissipation framework were employed for comprehensive analysis.The pristine highland specimens achieved 5.79 MPa and a peak strain of 0.13(50 mm×50 mm×30 mm),significantly outperforming their mare counterparts.Wire-cutting to 20 mm×20 mm×20 mm lowered strength by~20%and peak strain to 0.04,indicating cutting-induced defects reduce ductility.All specimens displayed multipeaked stress–strain curves.3D-DIC revealed band-type strain localization in pristine highland samples,diffuse strain patterns in cut highland samples,and highly tortuous,network-type bands in mare samples;the anisotropy index was also quantified.Fragmented particles exhibited fractal dimensions ranging from 1.6 to 2.0(size 1.25–9 mm).Energy evolution progressed through three distinct stages:elastic energy storage,progressive energy dissipation delaying crack propagation,and final unstable collapse.An energy-based damage model was established and validated.The data and methods developed support Chang'E-8 missions'ISRU demonstrations and establish a transferable framework toward sustainable lunar habitats.展开更多
Electrochemical carbon dioxide(CO2)reduction(ECO2R)is an increasingly valuable technology that converts CO2into useful chemicals using various catalyst materials.This review underlines the advantages of ECO_(...Electrochemical carbon dioxide(CO2)reduction(ECO2R)is an increasingly valuable technology that converts CO2into useful chemicals using various catalyst materials.This review underlines the advantages of ECO2R electrolyzers that use low-temperature electrolysis(25-80℃)over other high-temperature electrolysis methods,particularly for applications in outer space.The potential of this technology for Mars missions is particularly intriguing,opening up new possibilities for in-situ resource utilization(ISRU)processes in upcoming space missions.This review also explores technology's commercial potential and the importance of utilizing gas diffusion electrodes(GDEs)to enhance the ECO2R process,ECO2R has the potential to transform outer-space activities and space exploration by significantly reducing the use of Earth's resources.It offers a sustainable alternative for continuous fuel and chemical production by utilizing gaseous CO2,thereby reducing its carbon footprint on Earth,and presents a promising process for outer-space applications.展开更多
Carbon dioxide(CO2)is the main greenhouse gas(GHG)released by human activities.The substitution of fossil resources by biomass as a bio-renewable resource,has significant potential to reduce GHG emissions.The appro...Carbon dioxide(CO2)is the main greenhouse gas(GHG)released by human activities.The substitution of fossil resources by biomass as a bio-renewable resource,has significant potential to reduce GHG emissions.The approach to biomass,as the only true full-scale alternative to fossil resources,is progressing rapidly.Converting biomass into furanic compounds,as versatile platform chemicals for synthesizing a wide range of bio-based products is the cornerstone of sustainable technologies.The extensive body of this review combines the biomass valorization to furanic compounds by CO2utilization and furanic compounds conversion by CO2fixation.These processes can be strategically applied through both‘thermochemical’and‘electrochemical’pathways,by utilizing CO2from the atmosphere or industrial emission point and returning it to the natural carbon cycle.In the thermochemical pathway CO2acts as a carbon source(carboxylation and polymerization)or active reaction assistant in the biomass conversion(CO2-assisted conversion),without altering its oxidation state,facilitating the synthesis of valuable products and polymers.Conversely,in the electrochemical pathway,CO2can be used as a carbon source(electrocarboxylation)to give the corresponding carboxylic acid,or it can undergo reduction,yielding methanol,carbon monoxide(CO),formic acid,and analogous compounds,while on the other side,furanic compounds undergo oxidation yielding high-value-added chemicals.Finally,potential future research directions are suggested to promote CO2utilization and fixation in the valorization of biomass-derived furanic compounds,and challenges facing further research are highlighted.展开更多
In this study,we examine China’s partially marketized wholesale power generation sector.A political economy approach is adopted to understand the“dual-track”system in which electricity production is coordinated thr...In this study,we examine China’s partially marketized wholesale power generation sector.A political economy approach is adopted to understand the“dual-track”system in which electricity production is coordinated through a combination of government planning and market transactions.By reviewing and synthesizing China’s policies and institutions that govern the dispatch of power generation,we develop a competitive bargaining model,under which power plants compete for production quotas by bargaining with government superiors using both market and nonmarket leverage.First,we hypothesize that power plants that are larger,cleaner,more fuel-efficient,and more politically powerful can bargain for more production quotas.Second,we hypothesize that long-term power purchase contracts can increase eligible power plants’production and profitability.Then,we analyze data on the operational characteristics of China’s coal-fired power plants,and the empirical results largely verify the two hypotheses.Overall,this study demonstrates that even though China’s mixed wholesale generation market does not explicitly internalize fuel and environmental costs,it can promote energy conservation and pollution reduction when supported by the right policies.In addition,this“dual-track”approach is more politically viable than the fully marketized economic dispatch model because it more accurately aligns with China’s long-standing institutions of economic transition and governance.展开更多
BACKGROUND Patient education remains an underdeveloped component of care in abdominal transplantation.Despite the benefits of improved health literacy,most educational materials remain inaccessible to the average pati...BACKGROUND Patient education remains an underdeveloped component of care in abdominal transplantation.Despite the benefits of improved health literacy,most educational materials remain inaccessible to the average patient.AIM To evaluate the impact of educational booklets on comprehension,anxiety,satisfaction,and healthcare utilization among abdominal transplant recipients and donors.METHODS An observational,single-center quality improvement study was conducted in transplant recipients and living donors.Patients received booklets during transplant evaluation,preoperative clinic,or hospital admission.Booklets were developed by transplant surgeons and revised with health literacy experts.Postoperative surveys assessed comprehension,satisfaction,anxiety,and feedback.Patient-reported demographic data and postoperative outcomes were collected from the electronic medical record were analyzed.RESULTS Eighty-three patients completed the survey,of which nine were excluded for duplicate entries.Satisfaction with content was high,with 81%reporting reduced feelings of overwhelm and 74%reporting less fear of surgery.The average recommendation rating was 9.4/10,with frequent praise for illustrations,glossary,and surgical explanations.Postoperative outcomes improved following booklet implementation,with reductions in readmission rates,emergency department visits,and coordinator calls.Compared with historical data,readmissions decreased significantly(12.2%vs 22.1%;P=0.049).CONCLUSION Illustrated educational booklets significantly improved patient comprehension,anxiety,and satisfaction,and reduced unplanned care use.Integrating tailored education into routine transplant care enhances patient experiences and outcomes.展开更多
BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
Among the “three data rights,” the data utilization right has been persistently overlooked, and is similar to a neglected “middle child” in the context of the data rights family. However, it is precisely during th...Among the “three data rights,” the data utilization right has been persistently overlooked, and is similar to a neglected “middle child” in the context of the data rights family. However, it is precisely during the stages of processing and utilization that data undergoes its transformations and where its economic value is ultimately created. A series of recent policy documents on treating data as a factor of production have emphasized that the building of a scientific data property rights system requires a fair and efficient mechanism for benefit distribution, which provides reasonable preference for creators of data value and use value in terms of the income generated by data elements. Constrained by the inertial thinking of property right logic, the data utilization right is often regarded as a “transitional fulcrum” wherein the holders of data resources have to authorize the operators of data products to realize data value thereby. In the future structural design and implementation of the coordination mechanism for the property right system against the backdrop of the data factor-oriented reform, the establishment of data processing and utilization as an independent right will require the implementation of two core initiatives: first, attaching importance to the independent protection of the benefit distribution;second, implementing risk regulation for data security through optimization of governance. These two initiatives will serve as the key for optimizing the data factor governance system and accelerating the release of data value.展开更多
BACKGROUND Atrial fibrillation(AF)is a prevalent arrhythmia associated with increased stroke risk,morbidity,and healthcare burden.Oral anticoagulation(OAC)is essential for stroke prevention,but adherence is often subo...BACKGROUND Atrial fibrillation(AF)is a prevalent arrhythmia associated with increased stroke risk,morbidity,and healthcare burden.Oral anticoagulation(OAC)is essential for stroke prevention,but adherence is often suboptimal.Smartphone-based mobile health(mHealth)applications offer potential to enhance adherence,quality of life(QoL),and reduce healthcare utilization.AIM To systematically review randomized controlled trials(RCTs)evaluating the impact of smartphone-based mHealth interventions on OAC adherence,health-related QoL,and healthcare utilization in adults with AF.METHODS Following PRISMA guidelines and a PROSPERO-registered protocol(CRD420251169904),databases(PubMed,Scopus,Web of Science,EMBASE,Cochrane CENTRAL,CINAHL,ClinicalTrials.gov)were searched from January 1,2000,to July 30,2025.Eligible studies were RCTs of mHealth apps for AF management in adults(≥18 years).Two reviewers screened records,extracted data,and assessed risk of bias using Cochrane risk of bias 2.Narrative synthesis was used due to heterogeneity.RESULTS Of 968 records,16 RCTs(n=209-3324 participants)were included,primarily from China,United States,Taiwan,and South Korea.Integrated interventions(e.g.,mAFA-II aligning with AF better care pathway)improved OAC adherence(e.g.,higher self-reported scores,P<0.05;increased OAC persistence,P<0.001),enhanced QoL(e.g.,EQ-5D improvements,P<0.001),and reduced healthcare utilization(e.g.,rehospitalizations hazard ratio=0.32,P<0.001)without increasing bleeding risks.Simpler apps showed inconsistent benefits.Heterogeneity in designs,adherence measures,and follow-up(3 months to 2 years)limited generalizability.Risk of bias was high in 10 studies due to open-label designs and post-hoc analyses.CONCLUSION mHealth apps,especially comprehensive ones,can improve OAC adherence,QoL,and reduce utilization in AF patients.Future research should focus on long-term efficacy,cost-effectiveness,and equitable implementation for diverse populations.展开更多
Antimicrobial resistance(AMR)is a critical public health threat.As a densely populated megacity,Shanghai exhibits complex patterns of antibiotic consumption.This study evaluated temporal trends and hierarchical dispar...Antimicrobial resistance(AMR)is a critical public health threat.As a densely populated megacity,Shanghai exhibits complex patterns of antibiotic consumption.This study evaluated temporal trends and hierarchical disparities in antibiotic use across Shanghai's public hospitals(2017-2024)to inform targeted stewardship.Antibiotics were classified and quantified using the Anatomical Therapeutic Chemical/Defined Daily Dose(ATC/DDD)methodology.Comparative analyses were conducted across hospital tiers for the following metrics:DDDs,DDDs per 1000 inhabitants per day(DID),daily dose cost(DDC),and proportions of broad-spectrum antibiotics and parenteral formulations.Temporal trends were evaluated using compound annual growth rate(CAGR).From 2017 to 2024,public hospitals in Shanghai procured 257 distinct antimicrobial agents.DDDs demonstrated an initial decline followed by an increase,representing an overall reduction of 29.42%(CAGR=-4.86%).Meanwhile,DID fell by 29.90%(CAGR=-4.95%),with seasonal peaks in January,September,and December.Notably,the proportion of J01D antibiotics decreased by 35.78%,and the proportion of broad-spectrum anti-biotic use rose from 74.47%to 78.40%(CAGR=0.74%).Parenteral antibiotic use dropped substantially from 58.81%to 25.47%(CAGR=-11.27%),while its share of total expenditure remained high at 75%-80%.Considerable heterogeneity was observed across hospital levels:secondary and tertiary hospitals showed de-clining DDDs,the greatest reductions in parenteral and broad-spectrum antibiotic use,and increasing DDC,whereas primary hospitals had relatively stable utilization and lower DDC.Policy-related analyses indicated that National Essential Medicines List(NEML)drugs maintained lower DDC than non-NEML drugs but had a de-clining utilization share,while NRDL drugs increased their shares in both use and expenditure.Overall,total antibiotic consumption and the proportion of parenteral formulations in Shanghai have declined;however,the persistently high proportion of broad-spectrum antibiotics highlights ongoing challenges in antibiotic stew-ardship.Significant disparities across hospital tiers emphasize the need for tier-specific strategies and enhanced diagnostic precision to mitigate resistance.展开更多
The citrus processing industry in China generates a large amount of pomace by-products every year,and its resource utilization has become a research hotspot in the fields of food science,agricultural product processin...The citrus processing industry in China generates a large amount of pomace by-products every year,and its resource utilization has become a research hotspot in the fields of food science,agricultural product processing,and agroecology.Citrus pomace is rich in various high-value bioactive components such as pectin,polyphenols and flavonoids,carotenoids,and limonoids,and has functional properties including antioxidant,anti-inflammatory,and antibacterial activities.At present,the utilization of citrus pomace has formed three main pathways:direct crude utilization,extraction and utilization of active components,and microbial conversion utilization.Breakthroughs have also been made in emerging fields such as novel materials,asphalt modifiers,and active packaging films.However,core problems remain,including low comprehensive utilization efficiency,difficulties in industrializing processing techniques,poor stability of active components,low added value of products,and challenges in the collection,storage,and transportation of raw materials.Future research should focus on full-component cascade utilization,green and efficient processing technologies,stabilization techniques for active components,and the development of high value-added products,so as to promote the efficient transformation of citrus pomace from"waste"to"renewable resources"and support the green and sustainable development of the citrus industry.展开更多
基金Project(2023YFC2909000)supported by the National Key R&D Program Youth Scientist,ChinaProject(2024M751861)supported by the China Postdoctoral Science Foundation。
摘要Intergrown ferromanganese ore resources are typical strategic mineral resources with huge reserves and abundant hematite,pyrolusite,and other valuable minerals,which is of great significance for its development and utilization.This paper adopts a combination of phase transformation and magnetic separation to explore the phase transformation mechanism of Fe minerals and Mn minerals during the roasting process.The analysis of the properties of the raw ore shows that the Fe-containing and Mn-containing minerals of the intergrown ferromanganese ore are hematite and pyrolusite,respectively.The optimal conditions for controlling the mineral phase were obtained,including roasting temperature of 600℃ for 30 min,and a grinding fineness of<0.074 mm accounting for 50%.Meanwhile,a Fe grade of 61.05% with a recovery of 80.77%,and a Mn grade of 61.60% with a recovery of 87.81% were acquired.The precise mineral phase transformation(MPT)could be realized via adjusting the roasting conditions.Hematite is transformed into magnetite,while pyrolusite is transformed into manganosite,and then they were effectively separated and concentrated via magnetic separation.
基金supported by Guizhou Science and Technology Support Program Project(Grant No.Guizhou Science and Technology Cooperation Support(2025)General 079)Guizhou Provincial Department of Education’s“Top 100 Schools and Thousand Enterprises in Science and Technology Research and Development”Project in 2025(Grant No.Guizhou Education and Technology(2025)No.009)+3 种基金Guizhou Provincial Basic Research Program(Natural Science)Research Grants(Grant No.Qiankehe Foundation MS(2026)471)Guizhou Province Qianxinan Prefecture Science and Technology Support Program Project(Grant No.KJZC-2025-20)Hebei Provincial Natural Science Foundation(Grant No.H2022209089)Basic Scientific Research Business Expenses of Colleges and Universities in Hebei Province(Grant No.JYG2022001).
摘要Red mud is an alkaline solid waste generated by the alumina industry.Its annual global emissions have exceeded 180 million tons,and its prolonged open storage is prone to causing soil alkalization and air pollution.Red mud is considered to be a potential secondary resource given its rich valuable metal content.To realize the efficient resource utilization of red mud and convert solid waste into useful resources as much as possible,related researchers have carried out various studies on the recovery of iron from red mud.The relevant literature in recent years was summarized and analyzed.The research progress of iron resource recovery technology from red mud and the resource utilization of its tailings were also reviewed.In terms of iron recovery technologies,the process principles,technical characteristics,and limitations of these technologies for traditional methods such as physical sorting,pyrometallurgy,and hydrometallurgy,as well as emerging technologies including bioleaching,biomass pyrolysis reduction,and electrochemistry,are highlighted.A comparative analysis of the applicability of various technologies provides theoretical support for the selection of iron recovery processes under different conditions.At the same time,for the characteristics of the tailings produced after iron extraction from red mud,the ways of resource utilization in the fields of building materials and cementitious materials are discussed in depth,so as to realize the efficient utilization of the components of red mud.Finally,based on the research results obtained above and the current problems of red mud resource utilization,the sustainable development direction of red mud resource utilization in the future is prospected.
基金supported by BHP and China Baowu under their Climate Change Partnership‘Carbon Capture,Utilization,and Storage Technology Roadmap for Steel Industry’.
摘要Compressed carbon dioxide(CO2)energy storage(CCES)has emerged as a promising large-scale energy storage technology,characterized by high energy density,moderate critical temperature,and operational flexibility.Concurrently,carbon capture,utilization and storage(CCUS)technology represents a critical pathway toward carbon neutrality for energy systems.The integration of CCES with CCUS is attracting growing research interests due to its unique potential to synergize energy and carbon flows within a closed-loop framework.This paper provides a comprehensive literature review of technological advancements in CCES and offers a perspective on its integration with CCUS.First,the fundamental working principle,system configurations,key performance indicators,and emerging demonstration projects of CCES are introduced.Subsequently,cutting-edge research and key challenges of CCES system are reviewed,focusing on optimization of CO2-based mixed working media,efficient liquefaction of low-pressure CO2,development of low-cost and safe CO2 storage facilities,enhancement of system performance through integration,and evaluation of dynamic behaviors.A central focus is placed on the integration of CCES with CCUS,highlighting how this synergy transforms CCES from a pure storage technology into a multi-functional tool for carbon management.This integration enables infrastructure sharing,dual-function storage(for energy and CO2),and improved economics.Finally,this review identifies key directions for future research,including advancing efficient system integration,developing high-precision transient simulation models and dynamic control algorithms,ensuring long-term safety of geological reservoirs under cyclic injectionextraction operations,and establishing multi-objective optimization and multicriteria assessment frameworks to support the commercial deployment of integrated CCES-CCUS systems.
基金The International Partnership Program of Chinese Academy of Sciences,No.046GJHZ2023071MI。
摘要The comprehensive pattern of the natural environment constitutes a complex system shaped by interactions among multiple natural elements,including geology,terrain,climate,hydrology,soil,and biodiversity.The regional structure that embodies this complexity is defined as the comprehensive natural terrestrial system.Consequently,this system provides an integrated perspective for understanding the overall characteristics of the natural environment and resources.Pakistan,with agriculture as its core economic sector,has a natural environment that is inherently linked to its topographic and climatic conditions.Its geographical environmental conditions are similar to those of China.Through analysis of Pakistan's geological,geomorphological,climatological,hydrological,and vegetation conditions,we adopted the methodology of China's comprehensive natural regionalization to establish a comprehensive natural terrestrial system scheme for Pakistan.Hierarchically,this scheme is divided into 3 major regions,5 temperature zones,8 humidity areas,and 23 natural regions.The scheme reveals the diversity of Pakistan's natural environment and its three-dimensional geographical zonality characteristics.Furthermore,this study analyzes the ecological advantages,constraints,and resource development potential of each regional unit and proposes targeted strategies for ecological conservation and socioeconomic development.The scheme provides a scientific basis for the sustainable socioeconomic development of Pakistan.
基金funded by the National Natural Science Foundation of China(No.52470023)Beijing Nova Program,China(No.20240484634)the Cooperation Program of Scientific and Technological Innovation in Sichuan and Chongqing,China(No.CSTB2024TIAD-CYKJCXX0012).
摘要The role of organic carbon source as electron donor in incomplete denitrification,particularly in nitrite(NO2−)accumulation,remains crucial yet poorly understood.A detailed understanding of carbon and nitrogen metabolic interactions is essential for advancing technologies that integrate partial denitrification(PD)with anammox.In this study,the carbon transformation and gradient utilization of various volatile fatty acids(VFAs)were explored to elucidate their impacts on nitrate(NO3−)and NO2−reduction during PD.Long-term experiments revealed that composite VFAs(a mixture of acetate,propionate and butyrate)achieved the highest nitrate-to-nitrite transformation ratio(NTR)of 79.1%,outperforming single VFA(69.5%with acetate and 69.4%with propionate).The NO2−accumulation during PD was strongly influenced by the utilization of exogenous,endogenous and extracellular carbon,which varied significantly with VFAs type and dosage.Polyhydroxybutyrate(PHB)served as the primary endogenous electron donor in acetate-driven PD,promoting modest NO2−accumulation,while polyhydroxyvalerate(PHV)along with glycogen(Gly)was the key contributor in propionate-driven PD,supporting complete NO3−reduction.In contrast to single VFA-driven PD,the lower levels and delayed utilization of PHB and PHV in composite VFAs-driven PD enabled more stable and efficient NO2−accumulation.Furthermore,metagenomic analysis illuminated that the transition from single VFA to composite VFAs strengthened the potential for both electron production and their transport to NO3−reductase.Thauera was always the core denitrifier demonstrating strong adaptability to various VFAs.This study provides mechanistic insights into organic carbon-regulated NO2−accumulation,filling the gap regarding dynamic changes in carbon utilization during PD.
基金the financial support from Natural Science Funds of Hubei Province(2024AFB835).
摘要The utilization of water-cooled electric furnace ferronickel slag(EFFS)in concrete remains constrained by its intrinsically low pozzolanic reactivity as a supplementary cementitious material(SCM)and its inadequate volumetric stability when employed as aggregate.This study systematically investigates the compositional characteristics of this slag across different particle-size fractions and proposes a wet-grinding activation strategy to enhance its pozzolanic performance.In particular,cement pastes incorporating 10%,30%,and 50%ultrafine EFFS derived from three original size fractions are comprehensively evaluated in terms of rheological behavior,compressive strength,hydration characteristics,and microstructural evolution.The results demonstrate pronounced size-dependent differences in phase composition.The amorphous phase content of EFFS particles smaller than 1.0 mm(EFFS0)reaches 54.04%,which is 19.72%higher than that of particles larger than 1.8 mm(EFFS2).The higher amorphous content leads to enhanced pozzolanic activity and improved mechanical performance.Mortars containing 30%ultrafine EFFS0 exhibit favorable strength development,with the 28-day compressive strength reaching 96%of that of the plain cement control and showing a 29%increase relative to the corresponding EFFS2 mixture.Based on these findings,a graded utilization strategy for water-cooled EFFS is proposed:The finer and more reactive fractions are suitable for SCM applications after activation,whereas the coarser fractions are more appropriate for non-cementitious applications,such as aggregate utilization.
基金supported by National Natural Science Foundation of China(No.U23A20449)Central Guidance on Local Science and Technology Development Fund of Zhejiang Province(No.2024ZY01006).
摘要Liver transplantation(LT)faces persistent organ shortages driving innovations like split liver transplantation(SLT),domino liver transplantation(DLT)and auxiliary liver transplantation(ALT).SLT emerges as a transformative approach,enabling the transplantation of a solitary donor liver into two beneficiaries-a pediatric and an adult,an undertaking that curbs waiting list mortality rates for both demographics(1).Complementing this breakthrough,the advent of DLT permits the utilization of a liver from one transplant recipient as the donor organ for another patient,effectively facilitating the transplantation of two recipients using a“conventional”donor(2).ALT was initially used as the treatment for reversible fulminant liver failure(3).ALT has also been reported to have effective and long-term favorable results in patients with noncirrhotic metabolic liver disease and chronic cirrhotic liver disease(4,5).By amalgamating diverse transplantation methodologies,these advances serve to mitigate the organ shortage conundrum and,consequently,abate mortality on the transplant waiting list.Remarkably,we report an innovative clinical practice of LT encompassing three techniques:SLT,DLT,and ALT.These combined techniques materialize a remarkable achievement,wherein a single donor liver breathes life into three patients afflicted by end-stage liver disease,including one patient with massive liver cancer.
基金supported by the Faculty Development Internal Grant from the Newark College of Engineering,New Jersey Institute of Technology(NJIT),USA。
摘要Brittleness Index(BI),while not universally standardized,is one of the most critical parameters in the assessment of rock failure behavior,drillability,and excavation efficiency in mining;however,its applicability to extraterrestrial environments remains poorly constrained for the In-Situ Resource Utilization(ISRU)mission on Mars.This study qualitatively and quantitatively investigated the mechanistic attributes(compressive strength,σc;tensile strength,σt)and BI of simulated Martian rocks under distinct conditions.Martian analog rock specimens,developed using Mars Global Simulant,were subjected to controlled bulk-scale mechanical tests(uniaxial compression and Brazilian disc tests)to determineσcandσt,supported by SEM-EDS analyses,to validate mineralogical similarity with Martian samples.Results revealed that the simulated Martian rocks are representative of Jezero crater lithologies and exhibit behavior characterized by linear elastic deformation followed by abrupt failure under stress.A gravity-modified brittleness index(BIM1,BIM2,BIM3,and BIM4)was proposed,which yielded lower brittleness thresholds consistent with a mechanically weaker Martian lithosphere.Further,the Martian-specific brittleness classification indicated that the analog Martian rocks fall predominantly within low-tomoderately brittle categories(0.1<BIM4<9.3)under Martian conditions,suggesting favorable drillability and relatively low energy requirements for excavation.These findings offer novel insights into the feasibility of predicting Martian excavation performance for ISRU.
基金Supported by National Key R&D Program of China(2025YFE0109700)the National Natural Science Foundation of China(52106150)。
摘要CO2 capture and utilization(CCU)technologies have been recognized as crucial strategies for mitigating global warming,reducing carbon emission,and promoting resource circularity.As such,the design and development of related materials have attracted considerable research attention.Carbon-based materials,characterized by tunable pore structures,abundant active sites,high specific surface area,and excellent chemical stability,demonstrate significant potential for applications in CO2 capture and utilization.This review systematically analyzes the adsorption behaviors and performance variations of typical carbon materials,including activated carbon,porous carbon,graphene,and carbon nanotubes during CO2 capture processes.Concerning CO2 utilization,emphasis is placed on recent advances in the catalytic applications of carbon-based materials in key reactions such as methanation,reverse water-gas shift,dry reforming of methane,and alcohol synthesis.Moreover,the benefits and drawbacks of carbon materials in terms of CO2 adsorption capacity,catalytic activity,and stability are thoroughly evaluated,and their potential applications in integrated CO2 capture and utilization technologies are discussed.Finally,key strategies for enhancing the performance of carbonaceous materials through structural modulation and surface modification are elucidated.This review aims to provide theoretical guidance for the future development and large-scale implementation of carbon-based materials in CCU technologies.
基金supported by the National Natural Science Foundation of China(U23A20605,22075053)Anhui Provincial Natural Science Foundation(No.2108085ME178)Student Research Training Program(No.S202410360232).
摘要In view of the problems such as the low utilization efficiency of copper tailings solid waste,which leads to severe environmental pollution,and the easy combustibility of rigid polyurethane foam(RPUF)along with the generation of a large amount of toxic smoke during combustion,copper tailings were combined with melamine polyphosphate to prepare RPUF composites.The flame-retardant properties were investigated,and the structure–property relationship was clarified.It was found that when 16.7 g of copper tailings and 33.3 g of melamine polyphosphate were added,the limiting oxygen index increased to 23.0 vol.%,and the vertical burning rating(UL-94)reached V-0.The peak heat release rate was reduced by 27.79%compared to pure RPUF,and the fire growth index decreased to 4.54 kW/(m2s),representing a 75.42%reduction.The char residue rate at 750℃ increased from 17.6% to 28.51%.Moreover,the addition of copper tailings and melamine polyphosphate effectively promoted the charring of RPUF,forming a dense char layer with good fire resistance performance.
基金supported by the Young Student Project of National Natural Science Foundation of China(No.525B2139)the National Key Research and Development Program of China(Nos.2023YFB3711300 and 2021YFF0500301)the Space Application System of China Manned Space Program(No.KJZ-YYWCL404)。
摘要Targeting Chang'E-8 mission'in-situ resource utilization(ISRU)for sustainable lunar habitats,laser powder bed fusion(LPBF)provides a viable pathway for in-situ additive manufacturing of lunar regolith.To elucidate mission relevant mechanical behavior and failure mechanisms of LPBF fabricated lunar regolith simulants,mare type and highland type simulant specimens were produced.Microstructural characterization,mechanical test coupled with three-dimensional digital image correlation(3D-DIC),and an energy-dissipation framework were employed for comprehensive analysis.The pristine highland specimens achieved 5.79 MPa and a peak strain of 0.13(50 mm×50 mm×30 mm),significantly outperforming their mare counterparts.Wire-cutting to 20 mm×20 mm×20 mm lowered strength by~20%and peak strain to 0.04,indicating cutting-induced defects reduce ductility.All specimens displayed multipeaked stress–strain curves.3D-DIC revealed band-type strain localization in pristine highland samples,diffuse strain patterns in cut highland samples,and highly tortuous,network-type bands in mare samples;the anisotropy index was also quantified.Fragmented particles exhibited fractal dimensions ranging from 1.6 to 2.0(size 1.25–9 mm).Energy evolution progressed through three distinct stages:elastic energy storage,progressive energy dissipation delaying crack propagation,and final unstable collapse.An energy-based damage model was established and validated.The data and methods developed support Chang'E-8 missions'ISRU demonstrations and establish a transferable framework toward sustainable lunar habitats.
基金financially supported through Research Foundation Flanders(FWO)'s PhD Fellowship Strategic Basic Research(1SHCA24N),Brusselssupport from Flanders Innovation and Entrepreneurship(VLAIO)(HBC.2021.0586(CLUE))。
摘要Electrochemical carbon dioxide(CO2)reduction(ECO2R)is an increasingly valuable technology that converts CO2into useful chemicals using various catalyst materials.This review underlines the advantages of ECO2R electrolyzers that use low-temperature electrolysis(25-80℃)over other high-temperature electrolysis methods,particularly for applications in outer space.The potential of this technology for Mars missions is particularly intriguing,opening up new possibilities for in-situ resource utilization(ISRU)processes in upcoming space missions.This review also explores technology's commercial potential and the importance of utilizing gas diffusion electrodes(GDEs)to enhance the ECO2R process,ECO2R has the potential to transform outer-space activities and space exploration by significantly reducing the use of Earth's resources.It offers a sustainable alternative for continuous fuel and chemical production by utilizing gaseous CO2,thereby reducing its carbon footprint on Earth,and presents a promising process for outer-space applications.
基金the National Key R&D Program of China(No.2021YFC2101604)National Natural Science Foundation of China(Nos.U23A20123,22278339)+1 种基金Fujian Provincial Key Science and Technology Program of China(No.2022YZ037013)Xiamen University for the financial support.
摘要Carbon dioxide(CO2)is the main greenhouse gas(GHG)released by human activities.The substitution of fossil resources by biomass as a bio-renewable resource,has significant potential to reduce GHG emissions.The approach to biomass,as the only true full-scale alternative to fossil resources,is progressing rapidly.Converting biomass into furanic compounds,as versatile platform chemicals for synthesizing a wide range of bio-based products is the cornerstone of sustainable technologies.The extensive body of this review combines the biomass valorization to furanic compounds by CO2utilization and furanic compounds conversion by CO2fixation.These processes can be strategically applied through both‘thermochemical’and‘electrochemical’pathways,by utilizing CO2from the atmosphere or industrial emission point and returning it to the natural carbon cycle.In the thermochemical pathway CO2acts as a carbon source(carboxylation and polymerization)or active reaction assistant in the biomass conversion(CO2-assisted conversion),without altering its oxidation state,facilitating the synthesis of valuable products and polymers.Conversely,in the electrochemical pathway,CO2can be used as a carbon source(electrocarboxylation)to give the corresponding carboxylic acid,or it can undergo reduction,yielding methanol,carbon monoxide(CO),formic acid,and analogous compounds,while on the other side,furanic compounds undergo oxidation yielding high-value-added chemicals.Finally,potential future research directions are suggested to promote CO2utilization and fixation in the valorization of biomass-derived furanic compounds,and challenges facing further research are highlighted.
基金financial support provided by the Major Program of the National Social Science Fund of China“Research on the Practical Pathways for High-Quality Development of New Energy and Energy System Transformation”[Grant No.25&ZD189]。
摘要In this study,we examine China’s partially marketized wholesale power generation sector.A political economy approach is adopted to understand the“dual-track”system in which electricity production is coordinated through a combination of government planning and market transactions.By reviewing and synthesizing China’s policies and institutions that govern the dispatch of power generation,we develop a competitive bargaining model,under which power plants compete for production quotas by bargaining with government superiors using both market and nonmarket leverage.First,we hypothesize that power plants that are larger,cleaner,more fuel-efficient,and more politically powerful can bargain for more production quotas.Second,we hypothesize that long-term power purchase contracts can increase eligible power plants’production and profitability.Then,we analyze data on the operational characteristics of China’s coal-fired power plants,and the empirical results largely verify the two hypotheses.Overall,this study demonstrates that even though China’s mixed wholesale generation market does not explicitly internalize fuel and environmental costs,it can promote energy conservation and pollution reduction when supported by the right policies.In addition,this“dual-track”approach is more politically viable than the fully marketized economic dispatch model because it more accurately aligns with China’s long-standing institutions of economic transition and governance.
基金Supported by Donor Alliance Foundation Grant,No.2023-2024-6024171170.
摘要BACKGROUND Patient education remains an underdeveloped component of care in abdominal transplantation.Despite the benefits of improved health literacy,most educational materials remain inaccessible to the average patient.AIM To evaluate the impact of educational booklets on comprehension,anxiety,satisfaction,and healthcare utilization among abdominal transplant recipients and donors.METHODS An observational,single-center quality improvement study was conducted in transplant recipients and living donors.Patients received booklets during transplant evaluation,preoperative clinic,or hospital admission.Booklets were developed by transplant surgeons and revised with health literacy experts.Postoperative surveys assessed comprehension,satisfaction,anxiety,and feedback.Patient-reported demographic data and postoperative outcomes were collected from the electronic medical record were analyzed.RESULTS Eighty-three patients completed the survey,of which nine were excluded for duplicate entries.Satisfaction with content was high,with 81%reporting reduced feelings of overwhelm and 74%reporting less fear of surgery.The average recommendation rating was 9.4/10,with frequent praise for illustrations,glossary,and surgical explanations.Postoperative outcomes improved following booklet implementation,with reductions in readmission rates,emergency department visits,and coordinator calls.Compared with historical data,readmissions decreased significantly(12.2%vs 22.1%;P=0.049).CONCLUSION Illustrated educational booklets significantly improved patient comprehension,anxiety,and satisfaction,and reduced unplanned care use.Integrating tailored education into routine transplant care enhances patient experiences and outcomes.
摘要BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
摘要Among the “three data rights,” the data utilization right has been persistently overlooked, and is similar to a neglected “middle child” in the context of the data rights family. However, it is precisely during the stages of processing and utilization that data undergoes its transformations and where its economic value is ultimately created. A series of recent policy documents on treating data as a factor of production have emphasized that the building of a scientific data property rights system requires a fair and efficient mechanism for benefit distribution, which provides reasonable preference for creators of data value and use value in terms of the income generated by data elements. Constrained by the inertial thinking of property right logic, the data utilization right is often regarded as a “transitional fulcrum” wherein the holders of data resources have to authorize the operators of data products to realize data value thereby. In the future structural design and implementation of the coordination mechanism for the property right system against the backdrop of the data factor-oriented reform, the establishment of data processing and utilization as an independent right will require the implementation of two core initiatives: first, attaching importance to the independent protection of the benefit distribution;second, implementing risk regulation for data security through optimization of governance. These two initiatives will serve as the key for optimizing the data factor governance system and accelerating the release of data value.
摘要BACKGROUND Atrial fibrillation(AF)is a prevalent arrhythmia associated with increased stroke risk,morbidity,and healthcare burden.Oral anticoagulation(OAC)is essential for stroke prevention,but adherence is often suboptimal.Smartphone-based mobile health(mHealth)applications offer potential to enhance adherence,quality of life(QoL),and reduce healthcare utilization.AIM To systematically review randomized controlled trials(RCTs)evaluating the impact of smartphone-based mHealth interventions on OAC adherence,health-related QoL,and healthcare utilization in adults with AF.METHODS Following PRISMA guidelines and a PROSPERO-registered protocol(CRD420251169904),databases(PubMed,Scopus,Web of Science,EMBASE,Cochrane CENTRAL,CINAHL,ClinicalTrials.gov)were searched from January 1,2000,to July 30,2025.Eligible studies were RCTs of mHealth apps for AF management in adults(≥18 years).Two reviewers screened records,extracted data,and assessed risk of bias using Cochrane risk of bias 2.Narrative synthesis was used due to heterogeneity.RESULTS Of 968 records,16 RCTs(n=209-3324 participants)were included,primarily from China,United States,Taiwan,and South Korea.Integrated interventions(e.g.,mAFA-II aligning with AF better care pathway)improved OAC adherence(e.g.,higher self-reported scores,P<0.05;increased OAC persistence,P<0.001),enhanced QoL(e.g.,EQ-5D improvements,P<0.001),and reduced healthcare utilization(e.g.,rehospitalizations hazard ratio=0.32,P<0.001)without increasing bleeding risks.Simpler apps showed inconsistent benefits.Heterogeneity in designs,adherence measures,and follow-up(3 months to 2 years)limited generalizability.Risk of bias was high in 10 studies due to open-label designs and post-hoc analyses.CONCLUSION mHealth apps,especially comprehensive ones,can improve OAC adherence,QoL,and reduce utilization in AF patients.Future research should focus on long-term efficacy,cost-effectiveness,and equitable implementation for diverse populations.
基金funded by the National Natural Science Foundation of China Scientists Fund(Grant No.:72174041).
摘要Antimicrobial resistance(AMR)is a critical public health threat.As a densely populated megacity,Shanghai exhibits complex patterns of antibiotic consumption.This study evaluated temporal trends and hierarchical disparities in antibiotic use across Shanghai's public hospitals(2017-2024)to inform targeted stewardship.Antibiotics were classified and quantified using the Anatomical Therapeutic Chemical/Defined Daily Dose(ATC/DDD)methodology.Comparative analyses were conducted across hospital tiers for the following metrics:DDDs,DDDs per 1000 inhabitants per day(DID),daily dose cost(DDC),and proportions of broad-spectrum antibiotics and parenteral formulations.Temporal trends were evaluated using compound annual growth rate(CAGR).From 2017 to 2024,public hospitals in Shanghai procured 257 distinct antimicrobial agents.DDDs demonstrated an initial decline followed by an increase,representing an overall reduction of 29.42%(CAGR=-4.86%).Meanwhile,DID fell by 29.90%(CAGR=-4.95%),with seasonal peaks in January,September,and December.Notably,the proportion of J01D antibiotics decreased by 35.78%,and the proportion of broad-spectrum anti-biotic use rose from 74.47%to 78.40%(CAGR=0.74%).Parenteral antibiotic use dropped substantially from 58.81%to 25.47%(CAGR=-11.27%),while its share of total expenditure remained high at 75%-80%.Considerable heterogeneity was observed across hospital levels:secondary and tertiary hospitals showed de-clining DDDs,the greatest reductions in parenteral and broad-spectrum antibiotic use,and increasing DDC,whereas primary hospitals had relatively stable utilization and lower DDC.Policy-related analyses indicated that National Essential Medicines List(NEML)drugs maintained lower DDC than non-NEML drugs but had a de-clining utilization share,while NRDL drugs increased their shares in both use and expenditure.Overall,total antibiotic consumption and the proportion of parenteral formulations in Shanghai have declined;however,the persistently high proportion of broad-spectrum antibiotics highlights ongoing challenges in antibiotic stew-ardship.Significant disparities across hospital tiers emphasize the need for tier-specific strategies and enhanced diagnostic precision to mitigate resistance.
基金Supported by National Innovation and Entrepreneurship Training Program for College Students(202610580007)Science and Technology Innovation Guidance Project of Zhaoqing(241223100090425)+1 种基金Key Projects of the Second Round Project of High-quality Development in Hundred Counties,Thousands Towns and Ten Thousand Villages for Rural Science and Technology Special Commissioners Dispatched by the Guangdong Provincial Department of Science and Technology(KTP20240684)Doctoral Scientific Research Initiation Fund Project of Zhaoqing University(611/230009).
摘要The citrus processing industry in China generates a large amount of pomace by-products every year,and its resource utilization has become a research hotspot in the fields of food science,agricultural product processing,and agroecology.Citrus pomace is rich in various high-value bioactive components such as pectin,polyphenols and flavonoids,carotenoids,and limonoids,and has functional properties including antioxidant,anti-inflammatory,and antibacterial activities.At present,the utilization of citrus pomace has formed three main pathways:direct crude utilization,extraction and utilization of active components,and microbial conversion utilization.Breakthroughs have also been made in emerging fields such as novel materials,asphalt modifiers,and active packaging films.However,core problems remain,including low comprehensive utilization efficiency,difficulties in industrializing processing techniques,poor stability of active components,low added value of products,and challenges in the collection,storage,and transportation of raw materials.Future research should focus on full-component cascade utilization,green and efficient processing technologies,stabilization techniques for active components,and the development of high value-added products,so as to promote the efficient transformation of citrus pomace from"waste"to"renewable resources"and support the green and sustainable development of the citrus industry.