Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is sig...Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.展开更多
Energy supply and ventilation for isolated offices in rural areas are strongly recommended to be powered by renewable or standalone energy systems under the concept of net-zero-energy building(netZEB).A rooftop solar ...Energy supply and ventilation for isolated offices in rural areas are strongly recommended to be powered by renewable or standalone energy systems under the concept of net-zero-energy building(netZEB).A rooftop solar chimney is one of the adopted methods for space ventilation to improve thermal comfort.This approach has not been investigated under forced convection to support the netZEB.The objective of the current work is to experimentally assess the effectiveness of natural and forced ventilation methods for a prototype net-zero-energy office with a rooftop solar chimney.The prototype is a low-cost office constructed in the solar research site at University Teknologi PETRONAS,Malaysia.The weather is typical of a tropical climate.Three cases have been investigated.Case-1 with closed-door natural ventilation,Case-2 with open-door natural ventilation,and Case-3 with forced ventilation.Many ventilation parameters have been evaluated to compare the three ventilation cases.The measurement results show that,whether natural or forced,the installed chimney created a stack effect that reduced the temperature inside the office,but not to the required comfortable ventilation temperature.The mean measured indoor temperatures are higher than the proposed ventilation comfort temperatures,with differences of 6,5.2,and 3.35°C for Case-1,Case-2,and Case-3,respectively.In natural ventilation,Case-2 reduced the indoor-to-outdoor temperature ratio by 2.7%and improved thermal comfort by 32.4%compared to Case-1.With forced ventilation,Case-3 reduced the indoor-to-outdoor temperature ratio by 27.3%and improved thermal comfort by 65.2%compared to Case-1.The large,unshaded glass windows have a significant negative effect on ventilation,and it is recommended to avoid such a design for netZEB in the tropical climate.展开更多
Phrenic nerve stimulation(PNS)may preserve diaphragm activation and mitigate multiorgan injury during mechanical ventilation(MV);however,a minimal invasive rat model integrating PNS with MV is lacking.We established a...Phrenic nerve stimulation(PNS)may preserve diaphragm activation and mitigate multiorgan injury during mechanical ventilation(MV);however,a minimal invasive rat model integrating PNS with MV is lacking.We established an omohyoid muscle-based PNS rat model combined with MV.Bilateral nerves were exposed within 20±2 min by transection at the intermediate tendon of omohyoid muscle,minimizing trauma and bleeding.Threshold stimulation(0.6±0.2 mA)correlated with body weight.Ventilator-synchronized stimulation increased compound muscle action potentials by~30%,whereas histology confirmed intact nerve.Physiological parameters remained stable throughout ventilation.This model provides a safe and scalable platform for mechanistic and preclinical studies on PNS-mediated protection against MV-induced organ injury.展开更多
Objective: To investigate the efficacy of optimizing the prone positioning ventilation care regimen in improving oxygenation status and clinical outcomes in patients with severe acute respiratory distress syndrome (AR...Objective: To investigate the efficacy of optimizing the prone positioning ventilation care regimen in improving oxygenation status and clinical outcomes in patients with severe acute respiratory distress syndrome (ARDS). Methods: A total of 100 severe ARDS patients were randomly divided into an observation group and a control group, each comprising 50 cases. The control group received conventional care, while the observation group received the optimized prone positioning ventilation care regimen. Comparison was made between the two groups regarding oxygenation index, blood gas parameters (PaCO₂, SaO₂, PaO₂), treatment-related metrics (frequency of mechanical ventilation support, duration of mechanical ventilation, length of hospital stay), and complication rates. Results: Post-treatment, the oxygenation index in the observation group (453.73 ± 12.84 mmHg) was significantly higher than that in the control group (411.05 ± 17.73 mmHg) (P = 0.007). The PaCO₂ level in the observation group was lower than that in the control group (P = 0.007), and both SaO₂ and PaO₂ values were statistically significantly lower (P = 0.007). The frequency of mechanical ventilation support (1.19 ± 0.12 episodes), duration of mechanical ventilation (6.42 ± 2.24 days), and length of hospital stay (17.42 ± 2.18 days) in the observation group were all markedly lower than those in the control group (P = 0.0035). The complication rate in the observation group was 10.00%, significantly lower than that in the control group (34.00%) (P = 0.0235). Conclusion: Optimized prone positioning ventilation care significantly improves oxygenation status, reduces mechanical ventilation duration and hospital stay time, and decreases complication incidence in severe ARDS patients, demonstrating high clinical applicability.展开更多
The accumulation of carbon monoxide(CO)in underground spaces poses a significant health hazard;therefore,effective ventilation is essential.This study presents a transient numerical analysis under turbulent flow condi...The accumulation of carbon monoxide(CO)in underground spaces poses a significant health hazard;therefore,effective ventilation is essential.This study presents a transient numerical analysis under turbulent flow conditions to evaluate CO dispersion,and identify optimal ventilation configurations.Both during normal operation and in scenarios with high localized concentrations,such as a fire event.The governing equations were solved using the finite volume method with the standard k-ε.Turbulence model.Three configurations were analyzed by varying the outlet location:Case A with an upper-left outlet,Case B with a mid-left outlet,and Case C with a lower-left outlet.The Reynolds number(Re)ranged from 500 to 10,000 to represent different flow velocities.The results showed that the time required to purge the interior region ranged from 11 to 16 s for Re=5000 and Re=10,000,achieving minimum average(CO)concentrations of 1 ppm.Case C exhibited cross-ventilation that enhanced contaminant removal,whereas Case A demonstrated the highest overall distribution efficiency(εC=14.364).In the localized fire scenario,crossventilation minimized CO propagation into the interior,with removal times ranging from 11 to 191 s.This depended on the fire location and the Reynolds number.This study demonstrates that outlet positioning,flow velocity,and the presence of thermal plumes significantly influence CO dispersion and removal.The findings provide practical design and operational guidelines for ventilation systems in confined underground environments,ensuring occupant safety and maintaining indoor air quality during both normal and emergency conditions.展开更多
BACKGROUND Auditory hallucinations are common among patients undergoing mechanical ventilation,are often linked to sedation and stress,and may prolong recovery.As such,effective nonpharmacological nursing strategies a...BACKGROUND Auditory hallucinations are common among patients undergoing mechanical ventilation,are often linked to sedation and stress,and may prolong recovery.As such,effective nonpharmacological nursing strategies are required.AIM To explore and evaluate the clinical effectiveness of non-pharmacological psychiatric nursing interventions for auditory hallucinations in patients undergoing mechanical ventilation.METHODS Retrospective clinical data from 110 patients with auditory hallucinations while undergoing mechanical ventilation were divided into 2 groups(n=55 each):study(bundled rehabilitation nursing),and control(routine care).The Auditory Hallucination Rating Scale and Hamilton Anxiety and Depression Scales(HAM-A and HAM-D,respectively)were used to assess changes in hallucinations and psychological status.Duration of mechanical ventilation,single auditory hallucinations,and hospital stay were compared.Sedation levels were assessed using the Richmond Agitation-Sedation Scale.RESULTS The study group exhibited significantly shorter mean duration of mechanical ventilation(6.56±1.13 days),single hallucinations(3.34±1.08 minutes),and hospital stay(12.22±1.07 days)compared with the control group(8.03±1.04 days,5.13±1.22 min,and 14.18±1.27 days,respectively)(P0.05).The study group exhibited lower Richmond Agitation-Sedation Scale scores both at and after extubation(P<0.05).Satisfaction with nursing care was higher in the intervention group(92.72%)than in the control group(76.36%)(P<0.05).CONCLUSION Bundled rehabilitation nursing interventions for auditory hallucinations in patients undergoing mechanical ventilation effectively improve hallucination symptoms and psychological status,shorten mechanical ventilation and hospitalization,promote recovery,and enhance patient satisfaction.展开更多
Air Conditioning and Mechanical Ventilation(ACMV)Systems are often used to maintain the thermal comfort and the indoor air qualityin office buildings in tropical climates.These ACMVs usually account for more than 5O%o...Air Conditioning and Mechanical Ventilation(ACMV)Systems are often used to maintain the thermal comfort and the indoor air qualityin office buildings in tropical climates.These ACMVs usually account for more than 5O%of the total energy consumption of the buildings.Compared to other available technologies,use of Phase Change Materials(PCMs)has been identified as an attractive innovative technology to reduce the peak cooling load and also to shift the peak cooling load to after office-hours.Temperature of building envelopes constructed using conventional materials such as bricks and concrete tend to vary with the surrounding environmental conditions,as they only absorb or release the sensible heat.On the contrary,PCMs can absorb or release much larger amount of thermal energy fromo the surrounding as latent heat,while maintaining the building envelope temperature unaffected under varying environmental conditions.Thus,conventional building envelopes accompanied with PCMs are able to significantly reduce the external heat gains into the conditioned spaces of the buildings,resulting a significant reduction in the peak cooling load.This study is mainly focused on exploring the applicability of PCMs for hot and humid tropical climates.Numerical analysis supported and validated by an experimental program and a case study revealed that by covering exterior of building envelop with 5 mm-10 mm thick PCMs can reduce the building peak cooling load by 8%-12%.Moreover,it was found that the peak cooling load could be easily shifted to after office hours by increasing the PCM thickness.Economic analysis showed that the PCMs with higher thermal cycles reduces the pay back periods up to 2-3 years and,further supported the use of low-temperature PCMs for building applications.Findings of this study recommend to incorporate the PCMs on the building envelops of the sunlit walls to reduce the peak cooling load of the building with the aim of reducing the energy consumption by the ACMV system.展开更多
Objective: To investigate the clinical efficacy of a risk-based, full-cycle hierarchical collaborative nursing model in patients receiving prone positioning ventilation in the ICU. Methods: A total of 62 patients who ...Objective: To investigate the clinical efficacy of a risk-based, full-cycle hierarchical collaborative nursing model in patients receiving prone positioning ventilation in the ICU. Methods: A total of 62 patients who underwent prone positioning ventilation in the ICU of Baoying County People's Hospital from December 2023 to January 2025 and met the study's inclusion/exclusion criteria were enrolled as subjects. They were randomly divided into a control group and an observation group (n=31 each) using a random number table. The control group received standard routine care for ICU prone positioning ventilation, while the observation group additionally received a risk-based, full-cycle hierarchical collaborative nursing approach encompassing comprehensive pressure ulcer prevention measures during position transitions, phased psychological support, sleep interventions, tiered health guidance, and multidisciplinary collaboration. Outcomes were compared regarding pressure ulcer incidence, anxiety/depression levels, sleep quality, health beliefs, and nursing satisfaction. Results: The observation group exhibited significantly lower pressure ulcer incidence than the control group (P<0.05). Post-intervention, the observation group showed superior improvements in anxiety/depression scores, sleep quality, and health belief scores compared to the control group (P<0.05). Nursing satisfaction was also higher in the observation group, with all intergroup differences being statistically significant (P<0.05). Conclusion: Implementing a risk-based, full-cycle hierarchical collaborative nursing approach for ICU patients on prone positioning ventilation effectively reduces pressure ulcer incidence, alleviates negative emotions in critical conditions, improves sleep quality, enhances patient health beliefs and nursing satisfaction, and contributes to better overall recovery outcomes, demonstrating substantial clinical value.展开更多
Objective: To investigate the efficacy of invasive mechanical ventilation followed by high-flow oxygen therapy in patients with respiratory failure. Methods: A total of 100 patients were enrolled and randomly divided ...Objective: To investigate the efficacy of invasive mechanical ventilation followed by high-flow oxygen therapy in patients with respiratory failure. Methods: A total of 100 patients were enrolled and randomly divided into a study group (n=50) and a control group (n=50). The control group received conventional invasive mechanical ventilation, while the study group received high-flow oxygen therapy sequentially after invasive mechanical ventilation. The overall clinical efficacy rates and blood gas parameters at baseline (T0),24 hours post-treatment (T1), and 72 hours post-treatment (T2) were compared between the two groups. Results: The overall efficacy rate in the study group was significantly higher than that in the control group. At T1 and T2, the pH and PaO₂ levels in the study group were significantly higher than those in the control group, while the PaCO₂ level was significantly lower;all differences were statistically significant. Conclusion: Sequential high-flow oxygen therapy following invasive mechanical ventilation can effectively improve clinical outcomes and blood gas parameters in patients with respiratory failure.展开更多
Objective:To investigate the application effect of intelligent empowerment standardized airway management process in patients receiving mechanical ventilation.Methods:A retrospective analysis was conducted on the clin...Objective:To investigate the application effect of intelligent empowerment standardized airway management process in patients receiving mechanical ventilation.Methods:A retrospective analysis was conducted on the clinical data of 79 EICU inpatients who underwent tracheal intubation and mechanical ventilation treatment at our hospital from January 2023 to May 2025.The patients were divided into a control group(conventional airway management process,n=40)and a study group(intelligent empowerment standardized airway management process,n=39)based on the intervention protocols they received.Oral health scores,dental plaque index,oral odor,serum inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)],clinical pulmonary infection score(CPIS),as well as the incidence of ventilator-associated pneumonia(VAP),duration of mechanical ventilation,and length of stay in the EICU were assessed before and after treatment.Results:The baseline values of all indicators were consistent between the two groups before intervention(p>0.05).After corresponding interventions,both groups showed significant improvements in Beck oral health scores,dental plaque index,and oral odor,with more pronounced improvements observed in the study group(p<0.05).After the intervention,the research group showed a significant decrease in serum CRP and PCT levels,as well as CPIS scores(p<0.05).In contrast,the control group experienced an increase in these three indicators to a certain extent(p<0.05).Moreover,the incidence of ventilator-associated pneumonia(VAP),duration of mechanical ventilation,and length of stay in the EICU were all lower in the research group compared to the control group,while the nurse’s compliance rate with the protocol was higher in the research group(p<0.05).Conclusion:The standardized airway management protocol empowered by intelligent technology can significantly improve nursing compliance,benefit oral health status,reduce the risk of pulmonary infection and systemic inflammation levels,and promote rapid patient recovery,demonstrating considerable potential for widespread adoption.展开更多
Objective: This study explores the impact of single-port thoracoscopic lobectomy on pulmonary ventilation-related indicators in patients with non-small cell lung cancer, aiming to provide evidence-based basis for opti...Objective: This study explores the impact of single-port thoracoscopic lobectomy on pulmonary ventilation-related indicators in patients with non-small cell lung cancer, aiming to provide evidence-based basis for optimizing clinical surgical plans. A total of 80 patients with stage I-II NSCLC who underwent surgery were selected and randomly divided into the observation group (SP-VATS) and the control group (traditional three-port thoracoscopic surgery). The pulmonary function and arterial blood gas indicators of the two groups before 1 day, 3 days, 7 days, and 1 month after surgery were compared, and the surgical-related indicators and complications were recorded. Results: The operation time, intraoperative blood loss, chest tube retention time, and hospital stay of the observation group were significantly better than those of the control group (P < 0.05);at each postoperative time point, the lung function indicators such as FEV₁, FVC, MVV, PEF, and DLCO and the PaO₂, SaO₂ of the observation group were significantly higher than those of the control group, and PaCO₂ was significantly lower than that of the control group (P < 0.05);the total incidence of complications in the observation group was lower than that in the control group (P < 0.05). Conclusion: SP-VATS treatment for NSCLC causes less trauma, causes less damage to the patient's pulmonary function, leads to faster postoperative recovery and fewer complications, is more conducive to postoperative respiratory rehabilitation of patients, and is worthy of clinical promotion.展开更多
Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respi...Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO2 and oxygenation index, significantly lower PaCO2, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.展开更多
Objective:To investigate the application effect of nursing intervention based on Failure Mode and Effects Analysis(FMEA)in Non-Invasive Positive Pressure Ventilation(NPPV)treatment for patients with Chronic Obstructiv...Objective:To investigate the application effect of nursing intervention based on Failure Mode and Effects Analysis(FMEA)in Non-Invasive Positive Pressure Ventilation(NPPV)treatment for patients with Chronic Obstructive Pulmonary Disease(COPD)complicated by Type II respiratory failure.Methods:Eighty patients with COPD complicated by Type II respiratory failure admitted from January 2024 to December 2025 were selected and randomly divided into a control group receiving conventional nursing and a study group receiving FMEA-based nursing intervention,with 40 cases in each group.Blood gas indicators,the incidence of adverse events,and quality of life scores were compared between the two groups after intervention.Results:After intervention,the blood gas indicators in the study group[PaO2(69.58±5.21)mmHg,PaCO2(46.83±4.56)mmHg,SaO2(93.87±2.75)%]were significantly better than those in the control group[PaO2(63.12±5.07)mmHg,PaCO2(52.15±4.89)mmHg,SaO2(90.36±2.89)%](p<0.05).The incidence of adverse events in the study group was significantly lower than that in the control group(p<0.05).After intervention,the scores of all dimensions of the St.George’s Respiratory Questionnaire(SGRQ)in the study group were significantly lower than those in the control group(p<0.05),indicating a more significant improvement in quality of life.Conclusion:The FMEA-based nursing intervention constructed in this study can effectively improve blood gas indicators during NPPV treatment for patients with COPD complicated by Type II respiratory failure,reduce the incidence of adverse events,and significantly improve patients’quality of life,providing a widely applicable prospective risk prevention and control plan for specialized nursing management in clinical NPPV treatment.展开更多
BACKGROUND:In this study,we aimed to evaluate the impact of mechanical ventilator(MV)utilizaton during cardiopulmonary resuscitation(CPR)on out-of-hospital cardiac arrest(OHCA)patient clinical outcomes in the emergenc...BACKGROUND:In this study,we aimed to evaluate the impact of mechanical ventilator(MV)utilizaton during cardiopulmonary resuscitation(CPR)on out-of-hospital cardiac arrest(OHCA)patient clinical outcomes in the emergency department.METHODS:This single-centered,retrospective,case-control study analyzed electronic medical records.Patients aged>18 years with non-traumatic OHCA who were treated at an emergency medical center between January 2019 and December 2023 were included.These patients were accessed according to the ventilatory method used:MV ventilation(volume control,tidal volume 6-8 mL/kg,frequency 10 beat per minute,inspiratory time 1 s)and manual resuscitator bag valve(BV)ventilation.The primary outcome was the return of spontaneous circulation(ROSC).After 1:1 propensity score matching,the clinical outcomes were analyzed.RESULTS:A total of 649 patients were enrolled in this study.Before matching,the clinical outcomes and pneumothorax incidence did not differ between the MV and BV groups.After 1:1 matching between the two groups using propensity scores,522 patients(261 MV and 261 BV)were analyzed.Propensity score matching yielded an adequate balance(standardized mean difference<0.10)for all covariates.The estimated odds ratio(OR)for ROSC was 1.23(95%confidence interval[CI]:0.85-1.77;P=0.267),for survival at hospital admission was 1.02(95%CI:0.68-1.53;P=0.918),for survival at hospital discharge was 2.31(95%CI:1.10-5.20;P=0.033),and for good neurologic outcome was 2.56(95%CI:0.84-9.43;P=0.116).CONCLUSION:In patients with OHCA admitted to the emergency department,MV ventilation during CPR showed clinical outcomes similar to those of BV ventilation in most measures.However,survival at hospital discharge was significantly higher in the MV group,suggesting potential benefits of MV use in selected patients.展开更多
During the train meeting events,train equipment compartments are exposed to the worst pressure changes,potentially affecting the ventilation performance of equipment,particularly for electrical facilities equipped wit...During the train meeting events,train equipment compartments are exposed to the worst pressure changes,potentially affecting the ventilation performance of equipment,particularly for electrical facilities equipped with independent air ducts.In this paper,a two-step method is used for numerical computation:(1)obtaining the temporal and spatial transient node data of the flow field sections during the train-passing simulation and(2)using the data as the input data for the equipment compartment simulation.In addition,this paper also compares the difference in equipment ventilation between the single-train and trainpassing scenarios in real vehicle tests.The results indicate that the primary factors influencing ventilation effectiveness are the aerodynamic compression and deceleration of airflow induced by the other train's nose,as well as the instability of the external flow field in the wake of the other train.During train crossing,the air is forced into the air duct,with a maximum ratio of the airflow in-duct to the airflow out-duct reaching 3.2.The average mass flow falls below the rated mass flow for the converter.Compared to the rated air volume of converter,the maximum suppression rates obtained from testing and simulation are-24.5%and-16.8%,respectively.Compared to the single-train operation,the maximum suppression rates obtained from testing and simulation are-15%and-18%,respectively.These findings provide valuable insights into the design and operation of high-speed trains.展开更多
With different structural forms of ventilation pipes have various attenuation effects on incident shock waves while meeting ventilation requirements.The attenuation mechanism and the propagation law of shock waves in ...With different structural forms of ventilation pipes have various attenuation effects on incident shock waves while meeting ventilation requirements.The attenuation mechanism and the propagation law of shock waves in ventilation pipes of different structures are investigated by experiments and numerical simulations.Furthermore,for the same structure,the effects of peak pressure and positive pressure time on the attenuation rate are discussed.It is found that the attenuation rate increases with the incident shock wave pressure,and the shock wave attenuation rate tends to reach its limiting value k for the same structure and reasonably short positive pressure time.Under the same conditions,the attenuation rate is calculated using the pressure of the shock wave as follows:diffusion chamber pipe,branch pipe and selfconsumption pipe;the attenuation rate per unit volume is calculated as follows:self-consumption pipe,branch pipe and diffusion chamber pipe.In addition,an easy method is provided to calculate the attenuation rate of the shock wave in single and multi-stage ventilation pipes.Corresponding parameters are provided for various structures,and the margin of error between the formulae and experimental results is within 10%,which is significant for engineering applications.展开更多
Variable air volume systems are widely used in trains as they provide effective energy savings for air conditioning.However,the design phase is usually carried out at a certain fixed airflow,resulting in a difference ...Variable air volume systems are widely used in trains as they provide effective energy savings for air conditioning.However,the design phase is usually carried out at a certain fixed airflow,resulting in a difference between the expected and actual flow fields.In this study,we first analyzed the flow field characteristics at variable airflow rates under isothermal conditions,and subsequently established a correlation equation between the airflow and the flow field parameters.The results show that the airflow just entering the compartment conforms to the characteristics of an attached jet,and then,after converging in the middle,conforms to the characteristics of a free jet.The flow field characteristics are significantly correlated with the Reynolds number(Re)and are limited by the small space inside the vehicle.When Re≥2650,the axial velocities all conform to the classical um/u0−(x/b)r or um/u0−(y/b)r law,the sectional velocities conform to the exponential and Gaussian distributions,and the characteristic thicknesses of the jets conform to a linear distribution.Derivation shows that the entrainment suction flow rate is related mainly to the initial flow rate and the air opening width.The results of this study will inform the design of ventilation systems for high-speed trains.展开更多
BACKGROUND There has been a growing interest in noninvasive ventilation(NIV)in comparison to invasive mechanical ventilation(IMV)as a standard of care for acute respiratory failure(ARF),especially in the post-covid er...BACKGROUND There has been a growing interest in noninvasive ventilation(NIV)in comparison to invasive mechanical ventilation(IMV)as a standard of care for acute respiratory failure(ARF),especially in the post-covid era,but direct head-to-head cost comparisons between the two modalities are not available in literature.AIM To compare the cost along with the clinical effectiveness of NIV in comparison to IMV in ARF.METHODS A prospective observational single-center case control study including adult patients with ARF(PaO2/FiO2 ratio<300)admitted from January 1,2024 to December 31,2024 in medical intensive care unit(ICU)of a tertiary care hospital requiring either NIV or invasive ventilation.NIV and IMV groups were compared based on average length of ICU and hospital stay,mortality,net cost of ICU treatment,need for intubation and tracheostomy.RESULTS A total of 319 patients were included in the study(197 in NIV,122 in IMV group).Statistically significant difference in length of ICU stay(NIV group:5±3.25 days,IMV group:9±2.6 days;P<0.05)and mortality rate was seen(11%NIV vs 34%IMV;P<0.01).On multivariate analyses,mortality showed a stronger association with IMV[odds ratio(OR)=7.73;95%CI:3.12-19.18]as compared to ICU stay(OR=2.73;95%CI:2.15-3.48).A total of 33 patients(17%)in NIV group required intubation of which 3 were tracheostomized,while 14 patients(11%)in IMV group needed tracheostomy.The net average cost of ICU stay was₹83902 in NIV group while in IMV group,the net ICU cost was₹476216.The average cost of ICU stay was five times higher with IMV.CONCLUSION NIV has potential economic and clinical benefits as compared to invasive ventilation in ARF.展开更多
BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains rela...BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains relatively limited.This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.AIM To determine whether pressure-controlled ventilation(PCV)can lower peak airway pressures(PAPs)and reduce the incidence of barotrauma compared to volume-controlled ventilation(VCV),without compromising clinical outcomes and oxygenation parameters.METHODS We have evaluated 600 patients who were hospitalized due to a severe COPD exacerbation,with 400 receiving mechanical ventilation for the respiratory failure.The participants were divided into two different groups,who were administered either VCV or PCV,along with appropriate management.We thereafter observed patients'attributes,clinical factors,and laboratory,radiographic,and arterial blood gas evaluations at the start and during their stay in the intensive care unit(ICU).We have also employed appropriate statistical methods for the data analysis.RESULTS Both the VCV and PCV groups experienced significant enhancements in the respiratory rate,tidal volume,and arterial blood gas values during their time in the ICU.However,no significant distinctions were detected between the groups in terms of oxygenation indices(partial pressures of oxygenaction of inspired oxygen ratio)and partial pressures of carbon dioxide improvements.There was no considerable disparity observed between the VCV and PCV groups in the hospital mortality(32%vs 28%,P=0.53),the number of days of ICU stay[median interquartile range(IQR):9(6-14)d vs 8(5-13)d,P=0.41],or the duration of the mechanical ventilation[median(IQR):6(4-10)d vs 5(3-9)d,P=0.47].The PCV group displayed lower PAPs compared to the VCV group(P<0.05)from the beginning of mechanical ventilation until extubation or ICU departure.The occurrence of barotrauma was considerably lower in the PCV group in comparison to the VCV group(6%vs 16%,P=0.03).CONCLUSION Both VCV and PCV were found to be effective in treating patients with acute COPD exacerbation.However,PCV was associated with lower PAPs and a significant decrease in barotrauma,thus indicating that it might be a safer ventilation method for this group of patients.However,further large-scale study is necessary to confirm these findings and to identify the best ventilation approach for patients experiencing an acute COPD exacerbation.展开更多
Mechanical ventilation is a specialized oxygen therapy and life support technology with significant importance for critically ill patients.In fact,40%–66%of patients in the intensive care unit(ICU)require mechanical ...Mechanical ventilation is a specialized oxygen therapy and life support technology with significant importance for critically ill patients.In fact,40%–66%of patients in the intensive care unit(ICU)require mechanical ventilation.[1,2]However,the mechanical ventilation can lead to ventilatorassociated lung injury(VALI),[3]ultimately resulting in difficulties in weaning from mechanical ventilation,prolonged hospital stays,and even increased mortality.展开更多
摘要Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.
摘要Energy supply and ventilation for isolated offices in rural areas are strongly recommended to be powered by renewable or standalone energy systems under the concept of net-zero-energy building(netZEB).A rooftop solar chimney is one of the adopted methods for space ventilation to improve thermal comfort.This approach has not been investigated under forced convection to support the netZEB.The objective of the current work is to experimentally assess the effectiveness of natural and forced ventilation methods for a prototype net-zero-energy office with a rooftop solar chimney.The prototype is a low-cost office constructed in the solar research site at University Teknologi PETRONAS,Malaysia.The weather is typical of a tropical climate.Three cases have been investigated.Case-1 with closed-door natural ventilation,Case-2 with open-door natural ventilation,and Case-3 with forced ventilation.Many ventilation parameters have been evaluated to compare the three ventilation cases.The measurement results show that,whether natural or forced,the installed chimney created a stack effect that reduced the temperature inside the office,but not to the required comfortable ventilation temperature.The mean measured indoor temperatures are higher than the proposed ventilation comfort temperatures,with differences of 6,5.2,and 3.35°C for Case-1,Case-2,and Case-3,respectively.In natural ventilation,Case-2 reduced the indoor-to-outdoor temperature ratio by 2.7%and improved thermal comfort by 32.4%compared to Case-1.With forced ventilation,Case-3 reduced the indoor-to-outdoor temperature ratio by 27.3%and improved thermal comfort by 65.2%compared to Case-1.The large,unshaded glass windows have a significant negative effect on ventilation,and it is recommended to avoid such a design for netZEB in the tropical climate.
基金Outstanding Young Investigator Program of Capital Medical University,Grant/Award Number:A2308。
摘要Phrenic nerve stimulation(PNS)may preserve diaphragm activation and mitigate multiorgan injury during mechanical ventilation(MV);however,a minimal invasive rat model integrating PNS with MV is lacking.We established an omohyoid muscle-based PNS rat model combined with MV.Bilateral nerves were exposed within 20±2 min by transection at the intermediate tendon of omohyoid muscle,minimizing trauma and bleeding.Threshold stimulation(0.6±0.2 mA)correlated with body weight.Ventilator-synchronized stimulation increased compound muscle action potentials by~30%,whereas histology confirmed intact nerve.Physiological parameters remained stable throughout ventilation.This model provides a safe and scalable platform for mechanistic and preclinical studies on PNS-mediated protection against MV-induced organ injury.
摘要Objective: To investigate the efficacy of optimizing the prone positioning ventilation care regimen in improving oxygenation status and clinical outcomes in patients with severe acute respiratory distress syndrome (ARDS). Methods: A total of 100 severe ARDS patients were randomly divided into an observation group and a control group, each comprising 50 cases. The control group received conventional care, while the observation group received the optimized prone positioning ventilation care regimen. Comparison was made between the two groups regarding oxygenation index, blood gas parameters (PaCO₂, SaO₂, PaO₂), treatment-related metrics (frequency of mechanical ventilation support, duration of mechanical ventilation, length of hospital stay), and complication rates. Results: Post-treatment, the oxygenation index in the observation group (453.73 ± 12.84 mmHg) was significantly higher than that in the control group (411.05 ± 17.73 mmHg) (P = 0.007). The PaCO₂ level in the observation group was lower than that in the control group (P = 0.007), and both SaO₂ and PaO₂ values were statistically significantly lower (P = 0.007). The frequency of mechanical ventilation support (1.19 ± 0.12 episodes), duration of mechanical ventilation (6.42 ± 2.24 days), and length of hospital stay (17.42 ± 2.18 days) in the observation group were all markedly lower than those in the control group (P = 0.0035). The complication rate in the observation group was 10.00%, significantly lower than that in the control group (34.00%) (P = 0.0235). Conclusion: Optimized prone positioning ventilation care significantly improves oxygenation status, reduces mechanical ventilation duration and hospital stay time, and decreases complication incidence in severe ARDS patients, demonstrating high clinical applicability.
摘要The accumulation of carbon monoxide(CO)in underground spaces poses a significant health hazard;therefore,effective ventilation is essential.This study presents a transient numerical analysis under turbulent flow conditions to evaluate CO dispersion,and identify optimal ventilation configurations.Both during normal operation and in scenarios with high localized concentrations,such as a fire event.The governing equations were solved using the finite volume method with the standard k-ε.Turbulence model.Three configurations were analyzed by varying the outlet location:Case A with an upper-left outlet,Case B with a mid-left outlet,and Case C with a lower-left outlet.The Reynolds number(Re)ranged from 500 to 10,000 to represent different flow velocities.The results showed that the time required to purge the interior region ranged from 11 to 16 s for Re=5000 and Re=10,000,achieving minimum average(CO)concentrations of 1 ppm.Case C exhibited cross-ventilation that enhanced contaminant removal,whereas Case A demonstrated the highest overall distribution efficiency(εC=14.364).In the localized fire scenario,crossventilation minimized CO propagation into the interior,with removal times ranging from 11 to 191 s.This depended on the fire location and the Reynolds number.This study demonstrates that outlet positioning,flow velocity,and the presence of thermal plumes significantly influence CO dispersion and removal.The findings provide practical design and operational guidelines for ventilation systems in confined underground environments,ensuring occupant safety and maintaining indoor air quality during both normal and emergency conditions.
摘要BACKGROUND Auditory hallucinations are common among patients undergoing mechanical ventilation,are often linked to sedation and stress,and may prolong recovery.As such,effective nonpharmacological nursing strategies are required.AIM To explore and evaluate the clinical effectiveness of non-pharmacological psychiatric nursing interventions for auditory hallucinations in patients undergoing mechanical ventilation.METHODS Retrospective clinical data from 110 patients with auditory hallucinations while undergoing mechanical ventilation were divided into 2 groups(n=55 each):study(bundled rehabilitation nursing),and control(routine care).The Auditory Hallucination Rating Scale and Hamilton Anxiety and Depression Scales(HAM-A and HAM-D,respectively)were used to assess changes in hallucinations and psychological status.Duration of mechanical ventilation,single auditory hallucinations,and hospital stay were compared.Sedation levels were assessed using the Richmond Agitation-Sedation Scale.RESULTS The study group exhibited significantly shorter mean duration of mechanical ventilation(6.56±1.13 days),single hallucinations(3.34±1.08 minutes),and hospital stay(12.22±1.07 days)compared with the control group(8.03±1.04 days,5.13±1.22 min,and 14.18±1.27 days,respectively)(P0.05).The study group exhibited lower Richmond Agitation-Sedation Scale scores both at and after extubation(P<0.05).Satisfaction with nursing care was higher in the intervention group(92.72%)than in the control group(76.36%)(P<0.05).CONCLUSION Bundled rehabilitation nursing interventions for auditory hallucinations in patients undergoing mechanical ventilation effectively improve hallucination symptoms and psychological status,shorten mechanical ventilation and hospitalization,promote recovery,and enhance patient satisfaction.
摘要Air Conditioning and Mechanical Ventilation(ACMV)Systems are often used to maintain the thermal comfort and the indoor air qualityin office buildings in tropical climates.These ACMVs usually account for more than 5O%of the total energy consumption of the buildings.Compared to other available technologies,use of Phase Change Materials(PCMs)has been identified as an attractive innovative technology to reduce the peak cooling load and also to shift the peak cooling load to after office-hours.Temperature of building envelopes constructed using conventional materials such as bricks and concrete tend to vary with the surrounding environmental conditions,as they only absorb or release the sensible heat.On the contrary,PCMs can absorb or release much larger amount of thermal energy fromo the surrounding as latent heat,while maintaining the building envelope temperature unaffected under varying environmental conditions.Thus,conventional building envelopes accompanied with PCMs are able to significantly reduce the external heat gains into the conditioned spaces of the buildings,resulting a significant reduction in the peak cooling load.This study is mainly focused on exploring the applicability of PCMs for hot and humid tropical climates.Numerical analysis supported and validated by an experimental program and a case study revealed that by covering exterior of building envelop with 5 mm-10 mm thick PCMs can reduce the building peak cooling load by 8%-12%.Moreover,it was found that the peak cooling load could be easily shifted to after office hours by increasing the PCM thickness.Economic analysis showed that the PCMs with higher thermal cycles reduces the pay back periods up to 2-3 years and,further supported the use of low-temperature PCMs for building applications.Findings of this study recommend to incorporate the PCMs on the building envelops of the sunlit walls to reduce the peak cooling load of the building with the aim of reducing the energy consumption by the ACMV system.
摘要Objective: To investigate the clinical efficacy of a risk-based, full-cycle hierarchical collaborative nursing model in patients receiving prone positioning ventilation in the ICU. Methods: A total of 62 patients who underwent prone positioning ventilation in the ICU of Baoying County People's Hospital from December 2023 to January 2025 and met the study's inclusion/exclusion criteria were enrolled as subjects. They were randomly divided into a control group and an observation group (n=31 each) using a random number table. The control group received standard routine care for ICU prone positioning ventilation, while the observation group additionally received a risk-based, full-cycle hierarchical collaborative nursing approach encompassing comprehensive pressure ulcer prevention measures during position transitions, phased psychological support, sleep interventions, tiered health guidance, and multidisciplinary collaboration. Outcomes were compared regarding pressure ulcer incidence, anxiety/depression levels, sleep quality, health beliefs, and nursing satisfaction. Results: The observation group exhibited significantly lower pressure ulcer incidence than the control group (P<0.05). Post-intervention, the observation group showed superior improvements in anxiety/depression scores, sleep quality, and health belief scores compared to the control group (P<0.05). Nursing satisfaction was also higher in the observation group, with all intergroup differences being statistically significant (P<0.05). Conclusion: Implementing a risk-based, full-cycle hierarchical collaborative nursing approach for ICU patients on prone positioning ventilation effectively reduces pressure ulcer incidence, alleviates negative emotions in critical conditions, improves sleep quality, enhances patient health beliefs and nursing satisfaction, and contributes to better overall recovery outcomes, demonstrating substantial clinical value.
摘要Objective: To investigate the efficacy of invasive mechanical ventilation followed by high-flow oxygen therapy in patients with respiratory failure. Methods: A total of 100 patients were enrolled and randomly divided into a study group (n=50) and a control group (n=50). The control group received conventional invasive mechanical ventilation, while the study group received high-flow oxygen therapy sequentially after invasive mechanical ventilation. The overall clinical efficacy rates and blood gas parameters at baseline (T0),24 hours post-treatment (T1), and 72 hours post-treatment (T2) were compared between the two groups. Results: The overall efficacy rate in the study group was significantly higher than that in the control group. At T1 and T2, the pH and PaO₂ levels in the study group were significantly higher than those in the control group, while the PaCO₂ level was significantly lower;all differences were statistically significant. Conclusion: Sequential high-flow oxygen therapy following invasive mechanical ventilation can effectively improve clinical outcomes and blood gas parameters in patients with respiratory failure.
摘要Objective:To investigate the application effect of intelligent empowerment standardized airway management process in patients receiving mechanical ventilation.Methods:A retrospective analysis was conducted on the clinical data of 79 EICU inpatients who underwent tracheal intubation and mechanical ventilation treatment at our hospital from January 2023 to May 2025.The patients were divided into a control group(conventional airway management process,n=40)and a study group(intelligent empowerment standardized airway management process,n=39)based on the intervention protocols they received.Oral health scores,dental plaque index,oral odor,serum inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT)],clinical pulmonary infection score(CPIS),as well as the incidence of ventilator-associated pneumonia(VAP),duration of mechanical ventilation,and length of stay in the EICU were assessed before and after treatment.Results:The baseline values of all indicators were consistent between the two groups before intervention(p>0.05).After corresponding interventions,both groups showed significant improvements in Beck oral health scores,dental plaque index,and oral odor,with more pronounced improvements observed in the study group(p<0.05).After the intervention,the research group showed a significant decrease in serum CRP and PCT levels,as well as CPIS scores(p<0.05).In contrast,the control group experienced an increase in these three indicators to a certain extent(p<0.05).Moreover,the incidence of ventilator-associated pneumonia(VAP),duration of mechanical ventilation,and length of stay in the EICU were all lower in the research group compared to the control group,while the nurse’s compliance rate with the protocol was higher in the research group(p<0.05).Conclusion:The standardized airway management protocol empowered by intelligent technology can significantly improve nursing compliance,benefit oral health status,reduce the risk of pulmonary infection and systemic inflammation levels,and promote rapid patient recovery,demonstrating considerable potential for widespread adoption.
摘要Objective: This study explores the impact of single-port thoracoscopic lobectomy on pulmonary ventilation-related indicators in patients with non-small cell lung cancer, aiming to provide evidence-based basis for optimizing clinical surgical plans. A total of 80 patients with stage I-II NSCLC who underwent surgery were selected and randomly divided into the observation group (SP-VATS) and the control group (traditional three-port thoracoscopic surgery). The pulmonary function and arterial blood gas indicators of the two groups before 1 day, 3 days, 7 days, and 1 month after surgery were compared, and the surgical-related indicators and complications were recorded. Results: The operation time, intraoperative blood loss, chest tube retention time, and hospital stay of the observation group were significantly better than those of the control group (P < 0.05);at each postoperative time point, the lung function indicators such as FEV₁, FVC, MVV, PEF, and DLCO and the PaO₂, SaO₂ of the observation group were significantly higher than those of the control group, and PaCO₂ was significantly lower than that of the control group (P < 0.05);the total incidence of complications in the observation group was lower than that in the control group (P < 0.05). Conclusion: SP-VATS treatment for NSCLC causes less trauma, causes less damage to the patient's pulmonary function, leads to faster postoperative recovery and fewer complications, is more conducive to postoperative respiratory rehabilitation of patients, and is worthy of clinical promotion.
摘要Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO2 and oxygenation index, significantly lower PaCO2, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.
摘要Objective:To investigate the application effect of nursing intervention based on Failure Mode and Effects Analysis(FMEA)in Non-Invasive Positive Pressure Ventilation(NPPV)treatment for patients with Chronic Obstructive Pulmonary Disease(COPD)complicated by Type II respiratory failure.Methods:Eighty patients with COPD complicated by Type II respiratory failure admitted from January 2024 to December 2025 were selected and randomly divided into a control group receiving conventional nursing and a study group receiving FMEA-based nursing intervention,with 40 cases in each group.Blood gas indicators,the incidence of adverse events,and quality of life scores were compared between the two groups after intervention.Results:After intervention,the blood gas indicators in the study group[PaO2(69.58±5.21)mmHg,PaCO2(46.83±4.56)mmHg,SaO2(93.87±2.75)%]were significantly better than those in the control group[PaO2(63.12±5.07)mmHg,PaCO2(52.15±4.89)mmHg,SaO2(90.36±2.89)%](p<0.05).The incidence of adverse events in the study group was significantly lower than that in the control group(p<0.05).After intervention,the scores of all dimensions of the St.George’s Respiratory Questionnaire(SGRQ)in the study group were significantly lower than those in the control group(p<0.05),indicating a more significant improvement in quality of life.Conclusion:The FMEA-based nursing intervention constructed in this study can effectively improve blood gas indicators during NPPV treatment for patients with COPD complicated by Type II respiratory failure,reduce the incidence of adverse events,and significantly improve patients’quality of life,providing a widely applicable prospective risk prevention and control plan for specialized nursing management in clinical NPPV treatment.
摘要BACKGROUND:In this study,we aimed to evaluate the impact of mechanical ventilator(MV)utilizaton during cardiopulmonary resuscitation(CPR)on out-of-hospital cardiac arrest(OHCA)patient clinical outcomes in the emergency department.METHODS:This single-centered,retrospective,case-control study analyzed electronic medical records.Patients aged>18 years with non-traumatic OHCA who were treated at an emergency medical center between January 2019 and December 2023 were included.These patients were accessed according to the ventilatory method used:MV ventilation(volume control,tidal volume 6-8 mL/kg,frequency 10 beat per minute,inspiratory time 1 s)and manual resuscitator bag valve(BV)ventilation.The primary outcome was the return of spontaneous circulation(ROSC).After 1:1 propensity score matching,the clinical outcomes were analyzed.RESULTS:A total of 649 patients were enrolled in this study.Before matching,the clinical outcomes and pneumothorax incidence did not differ between the MV and BV groups.After 1:1 matching between the two groups using propensity scores,522 patients(261 MV and 261 BV)were analyzed.Propensity score matching yielded an adequate balance(standardized mean difference<0.10)for all covariates.The estimated odds ratio(OR)for ROSC was 1.23(95%confidence interval[CI]:0.85-1.77;P=0.267),for survival at hospital admission was 1.02(95%CI:0.68-1.53;P=0.918),for survival at hospital discharge was 2.31(95%CI:1.10-5.20;P=0.033),and for good neurologic outcome was 2.56(95%CI:0.84-9.43;P=0.116).CONCLUSION:In patients with OHCA admitted to the emergency department,MV ventilation during CPR showed clinical outcomes similar to those of BV ventilation in most measures.However,survival at hospital discharge was significantly higher in the MV group,suggesting potential benefits of MV use in selected patients.
基金support by Technology R&D Program of China State Railway Group Co.,Ltd(Grant number N2022J013)the Hunan Provincial Innovation Foundation for Postgraduate(Grant number CX20220279)+1 种基金the Fundamental Research Funds for the Central Universities of Central South University(Grant number 2022ZZTS0193)China Scholarship Council(202106370112)。
摘要During the train meeting events,train equipment compartments are exposed to the worst pressure changes,potentially affecting the ventilation performance of equipment,particularly for electrical facilities equipped with independent air ducts.In this paper,a two-step method is used for numerical computation:(1)obtaining the temporal and spatial transient node data of the flow field sections during the train-passing simulation and(2)using the data as the input data for the equipment compartment simulation.In addition,this paper also compares the difference in equipment ventilation between the single-train and trainpassing scenarios in real vehicle tests.The results indicate that the primary factors influencing ventilation effectiveness are the aerodynamic compression and deceleration of airflow induced by the other train's nose,as well as the instability of the external flow field in the wake of the other train.During train crossing,the air is forced into the air duct,with a maximum ratio of the airflow in-duct to the airflow out-duct reaching 3.2.The average mass flow falls below the rated mass flow for the converter.Compared to the rated air volume of converter,the maximum suppression rates obtained from testing and simulation are-24.5%and-16.8%,respectively.Compared to the single-train operation,the maximum suppression rates obtained from testing and simulation are-15%and-18%,respectively.These findings provide valuable insights into the design and operation of high-speed trains.
摘要With different structural forms of ventilation pipes have various attenuation effects on incident shock waves while meeting ventilation requirements.The attenuation mechanism and the propagation law of shock waves in ventilation pipes of different structures are investigated by experiments and numerical simulations.Furthermore,for the same structure,the effects of peak pressure and positive pressure time on the attenuation rate are discussed.It is found that the attenuation rate increases with the incident shock wave pressure,and the shock wave attenuation rate tends to reach its limiting value k for the same structure and reasonably short positive pressure time.Under the same conditions,the attenuation rate is calculated using the pressure of the shock wave as follows:diffusion chamber pipe,branch pipe and selfconsumption pipe;the attenuation rate per unit volume is calculated as follows:self-consumption pipe,branch pipe and diffusion chamber pipe.In addition,an easy method is provided to calculate the attenuation rate of the shock wave in single and multi-stage ventilation pipes.Corresponding parameters are provided for various structures,and the margin of error between the formulae and experimental results is within 10%,which is significant for engineering applications.
基金supported by the National Natural Science Foundation of China(No.12372049)the Independent Project of State Key Laboratory of Rail Transit Vehicle System(No.2025RVL-QY-T24),China.
摘要Variable air volume systems are widely used in trains as they provide effective energy savings for air conditioning.However,the design phase is usually carried out at a certain fixed airflow,resulting in a difference between the expected and actual flow fields.In this study,we first analyzed the flow field characteristics at variable airflow rates under isothermal conditions,and subsequently established a correlation equation between the airflow and the flow field parameters.The results show that the airflow just entering the compartment conforms to the characteristics of an attached jet,and then,after converging in the middle,conforms to the characteristics of a free jet.The flow field characteristics are significantly correlated with the Reynolds number(Re)and are limited by the small space inside the vehicle.When Re≥2650,the axial velocities all conform to the classical um/u0−(x/b)r or um/u0−(y/b)r law,the sectional velocities conform to the exponential and Gaussian distributions,and the characteristic thicknesses of the jets conform to a linear distribution.Derivation shows that the entrainment suction flow rate is related mainly to the initial flow rate and the air opening width.The results of this study will inform the design of ventilation systems for high-speed trains.
摘要BACKGROUND There has been a growing interest in noninvasive ventilation(NIV)in comparison to invasive mechanical ventilation(IMV)as a standard of care for acute respiratory failure(ARF),especially in the post-covid era,but direct head-to-head cost comparisons between the two modalities are not available in literature.AIM To compare the cost along with the clinical effectiveness of NIV in comparison to IMV in ARF.METHODS A prospective observational single-center case control study including adult patients with ARF(PaO2/FiO2 ratio<300)admitted from January 1,2024 to December 31,2024 in medical intensive care unit(ICU)of a tertiary care hospital requiring either NIV or invasive ventilation.NIV and IMV groups were compared based on average length of ICU and hospital stay,mortality,net cost of ICU treatment,need for intubation and tracheostomy.RESULTS A total of 319 patients were included in the study(197 in NIV,122 in IMV group).Statistically significant difference in length of ICU stay(NIV group:5±3.25 days,IMV group:9±2.6 days;P<0.05)and mortality rate was seen(11%NIV vs 34%IMV;P<0.01).On multivariate analyses,mortality showed a stronger association with IMV[odds ratio(OR)=7.73;95%CI:3.12-19.18]as compared to ICU stay(OR=2.73;95%CI:2.15-3.48).A total of 33 patients(17%)in NIV group required intubation of which 3 were tracheostomized,while 14 patients(11%)in IMV group needed tracheostomy.The net average cost of ICU stay was₹83902 in NIV group while in IMV group,the net ICU cost was₹476216.The average cost of ICU stay was five times higher with IMV.CONCLUSION NIV has potential economic and clinical benefits as compared to invasive ventilation in ARF.
摘要BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains relatively limited.This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.AIM To determine whether pressure-controlled ventilation(PCV)can lower peak airway pressures(PAPs)and reduce the incidence of barotrauma compared to volume-controlled ventilation(VCV),without compromising clinical outcomes and oxygenation parameters.METHODS We have evaluated 600 patients who were hospitalized due to a severe COPD exacerbation,with 400 receiving mechanical ventilation for the respiratory failure.The participants were divided into two different groups,who were administered either VCV or PCV,along with appropriate management.We thereafter observed patients'attributes,clinical factors,and laboratory,radiographic,and arterial blood gas evaluations at the start and during their stay in the intensive care unit(ICU).We have also employed appropriate statistical methods for the data analysis.RESULTS Both the VCV and PCV groups experienced significant enhancements in the respiratory rate,tidal volume,and arterial blood gas values during their time in the ICU.However,no significant distinctions were detected between the groups in terms of oxygenation indices(partial pressures of oxygenaction of inspired oxygen ratio)and partial pressures of carbon dioxide improvements.There was no considerable disparity observed between the VCV and PCV groups in the hospital mortality(32%vs 28%,P=0.53),the number of days of ICU stay[median interquartile range(IQR):9(6-14)d vs 8(5-13)d,P=0.41],or the duration of the mechanical ventilation[median(IQR):6(4-10)d vs 5(3-9)d,P=0.47].The PCV group displayed lower PAPs compared to the VCV group(P<0.05)from the beginning of mechanical ventilation until extubation or ICU departure.The occurrence of barotrauma was considerably lower in the PCV group in comparison to the VCV group(6%vs 16%,P=0.03).CONCLUSION Both VCV and PCV were found to be effective in treating patients with acute COPD exacerbation.However,PCV was associated with lower PAPs and a significant decrease in barotrauma,thus indicating that it might be a safer ventilation method for this group of patients.However,further large-scale study is necessary to confirm these findings and to identify the best ventilation approach for patients experiencing an acute COPD exacerbation.
摘要Mechanical ventilation is a specialized oxygen therapy and life support technology with significant importance for critically ill patients.In fact,40%–66%of patients in the intensive care unit(ICU)require mechanical ventilation.[1,2]However,the mechanical ventilation can lead to ventilatorassociated lung injury(VALI),[3]ultimately resulting in difficulties in weaning from mechanical ventilation,prolonged hospital stays,and even increased mortality.