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Comment on“Advances in the application of virtual reality technology in ophthalmic surgical skills training” 认领 引用
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作者 Van C.Lansingh Nicoletta Fynn-Thompson +2 位作者 Akshay Gopinathan Nair Minal ShahBaldota Stephen Chai 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第6期1216-1218,共3页
Dear Editor,We read with interest the article titled“Advances in the application of virtual reality technology in ophthalmic surgical skills training”[1].We congratulate the authors on their comprehensive review ... Dear Editor,We read with interest the article titled“Advances in the application of virtual reality technology in ophthalmic surgical skills training”[1].We congratulate the authors on their comprehensive review of an important and rapidly evolving topic:the use of virtual reality(VR)in cataract surgical training.We would like to expand on the discussion surrounding the“assessment of the cataract surgery training system’s effectiveness”. 展开更多
关键词 ophthalmic surgical skills training we ophthalmic surgical skills training virtual reality virtual reality vr training system effectiveness technological advancement cataract surgical trainingwe virtual reality technology
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Adaptive power and virtual resistance cooperation control strategy of VSG-based GFM converters for grid transient stability enhancement 认领 引用
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作者 Zhang Wen Liangzhong Yao +4 位作者 Fan Cheng Shuai Liang Junpeng Deng Siyang Liao Beilin Mao 《Global Energy Interconnection》 EI CSCD 2026年第3期489-504,共16页
With the increasing penetration level of renewable energy sources(RES)interfaced with the grids by power electronic converters,the grid forming(GFM)control of converters is recognized as one of the promising solutions... With the increasing penetration level of renewable energy sources(RES)interfaced with the grids by power electronic converters,the grid forming(GFM)control of converters is recognized as one of the promising solutions in dealing with challenges such as grid transient stability enhancement required for future power electronic converter-dominated power grids.However,the physical nature of the limited overcurrent capability of GFM converter constrains its application including grid transient stability enhancement during grid faults.To address this problem,this paper first analyzes the mechanism of grid transient stability and overcurrent of GFM converter during grid faults.Then,an adaptive power and virtual resistance cooperation control strategy of VSG-based GFM converter for grid transient stability enhancement is proposed,which can suppress the overcurrent of the GFM converter and enhance the grid transient stability simultaneously during grid faults.Meanwhile,a detailed quantitative analysis of parameter tuning of the proposed control is conducted,ensuring the robustness of the proposed control strategy in different fault depths and fault duration times.Finally,case studies are simulated in the PSCAD/EMTDC software to verify the effectiveness of the proposed control strategy. 展开更多
关键词 Transient stability control Virtual synchronous generator(VSG) Grid-forming(GFM)converter Current limiting strategy Virtual resistance
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Advances in the application of virtual reality technology in ophthalmic surgical skills training 认领 引用 被引量：1
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作者 Jia-Wen Wei Qing Zhang +4 位作者 Xiao-Yan Wang Ming-Xue Huang Jin-Hua Gan Wei-Hua Yang Wei Chi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第2期393-404,共12页
Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid adv... Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid advancement of computer technology has enabled the integration of virtual reality(VR)into medical training,thereby revolutionizing ophthalmic surgical education through VRbased educational methods.VR technology offers a safe,risk-free environment for trainees to practice repeatedly,enhancing surgical skills and accelerating the learning curve without compromising patient safety.This research outlines the application of VR technology in ophthalmic surgical skills training,particularly in cataract and vitreoretinal surgery.Including assessing the effectiveness of intraocular surgery training systems,evaluating skills transfer to the operating room,comparing it with wet lab cataract surgery training,and enhancing non-dominant hand training for cataract surgery,among other aspects.Additionally,this paper will identify the limitations of VR technology in ocular surgical skills training,offer improvement strategies,and detail the advantages and prospects,with the objective of guiding subsequent researchers. 展开更多
关键词 virtual reality ophthalmology ophthalmic surgical skills training surgical simulation cataract surgery vitreoretinal surgery
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Virtual Synchronous Generator Control Strategy Based on Parameter Self-Tuning 认领 引用
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作者 Jin Lin BinYu +3 位作者 Chao Chen Jiezhen Cai Yifan Wu Cunping Wang 《Energy Engineering》 EI 2026年第1期181-203,共23页
With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided b... With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided by synchronous generators.To address this critical issue,Virtual Synchronous Generator(VSG)technology has emerged as a highly promising solution by emulating the inertia and damping characteristics of conventional synchronous generators.To enhance the operational efficiency of virtual synchronous generators(VSGs),this study employs smallsignal modeling analysis,root locus methods,and synchronous generator power-angle characteristic analysis to comprehensively evaluate how virtual inertia and damping coefficients affect frequency stability and power output during transient processes.Based on these analyses,an adaptive control strategy is proposed:increasing the virtual inertia when the rotor angular velocity undergoes rapid changes,while strengthening the damping coefficient when the speed deviation exceeds a certain threshold to suppress angular velocity oscillations.To validate the effectiveness of the proposed method,a grid-connected VSG simulation platform was developed inMATLAB/Simulink.Comparative simulations demonstrate that the proposed adaptive control strategy outperforms conventional VSGmethods by significantly reducing grid frequency deviations and shortening active power response time during active power command changes and load disturbances.This approach enhances microgrid stability and dynamic performance,confirming its viability for renewable-dominant power systems.Future work should focus on experimental validation and real-world parameter optimization,while further exploring the strategy’s effectiveness in improvingVSG low-voltage ride-through(LVRT)capability and power-sharing applications in multi-parallel configurations. 展开更多
关键词 New power system grid-connected inverter virtual synchronous generator(VSG) virtual inertia damping coefficient adaptive control
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Unity-based virtual reality for detector and event visualization in JUNO experiment 认领 引用
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作者 Kai-Xuan Huang Tian-Zi Song +4 位作者 Yu-Ning Su Cheng-Xin Wu Xue-Sen Wang Yu-Mei Zhang Zheng-Yun You 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2026年第4期127-138,共12页
Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effect... Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effects and flexible extensibility for visualization in HEP experiments.In this study,we present a VR-based method for detector and event displays in the Jiangmen Underground Neutrino Observatory(JUNO)experiment.This method shares the same detector geometry descriptions and event data model as those in the offline software and provides the necessary data conversion interfaces.The VR methodology facilitates an immersive exploration of the virtual environment in JUNO,enabling users to investigate the detector geometry,visualize event data,and tune the detector simulation and event reconstruction algorithms.Additionally,this approach supports applications in data monitoring,physics data analysis,and public outreach initiatives. 展开更多
关键词 Virtual reality Event display Unity Detector geometry JUNO
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ICU nurses’experiences with virtual reality technology for workrelated stress reduction:A qualitative study 认领 引用
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作者 Yufeng Liang Xuepei Hong +2 位作者 Yihong Cai Xiuwan Chen Fuhong Chen 《International Journal of Nursing Sciences》 CSCD 2026年第2期149-155,I0002,共7页
Objectives:To explore experiences of ICU nurses with a virtual reality(VR)-based stress reduction intervention and identify the factors influencing its acceptance,guided by the Technology Acceptance Model.Methods:A qu... Objectives:To explore experiences of ICU nurses with a virtual reality(VR)-based stress reduction intervention and identify the factors influencing its acceptance,guided by the Technology Acceptance Model.Methods:A qualitative descriptive study was conducted in the ICU of a tertiary hospital in China.Fifteen nurses who had completed a VR intervention were recruited using purposive sampling.Data were collected through in-depth,semi-structured interviews between September and October 2025.The interviews were transcribed verbatim and analyzed using Colaizzi’s phenomenological method.Results:The analysis yielded five key themes.1)Perceived usefulness:nurses recognized VR’s effectiveness in reducing stress,primarily through mechanisms of immediate relaxation and psychological detachment from the high-pressure clinical environment.2)Perceived ease of use:the adoption process was hindered not only by technical issues but,more fundamentally,by a persistent inability to disengage from patient care responsibilities during use mentally.3)Influence of external variables:a critical barrier identified was the absence of structured organizational support,encompassing protected time,dedicated private spaces,and clear implementation policies.4)Behavioral intention and usage patterns:despite existing barriers,participants expressed a conditional willingness to adopt VR,integrating it flexibly into their routines for in-shift respite or post-shift recovery.5)Recommendations for improvement:practical suggestions for optimization focused on three areas,including diversifying VR content,improving hardware ergonomics,and establishing essential institutional enablers.Conclusions:VR technology has the potential to alleviate stress among ICU nurses.However,its sustainable integration into clinical practice requires a systemic approach that addresses multifaceted barriers,with organizational policy and support being the most critical enabling factor.Future initiatives must extend beyond technological optimization to include protected time,dedicated spaces,and supportive policies to ensure effectiveness and long-term adoption. 展开更多
关键词 Intensive care unit Nurse Occupational stress Qualitative research Virtual reality
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Blockchain-Enabled Trusted Virtual Network Embedding in Intelligent Cyber-Physical Systems 认领 引用
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作者 Zhu Hailong Huang Tao +2 位作者 Zhang Yi Chen Ning Zhang Peiying 《China Communications》 SCIE EI CSCD 2026年第1期175-188,共14页
With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Further... With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate. 展开更多
关键词 blockchain cyber-physical system trusted embedding virtual network
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Adaptive rehabilitation training for vestibular semicircular canal injury based on virtual reality technology 认领 引用
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作者 Xiaohua Sun Chengwei Fan +7 位作者 Senzhe Xu Yueyao Fu Wenjing Chen Sichao Liang Qian Li Yi Fan Songhai Zhang Xin Li 《Journal of Otology》 CSCD 2026年第2期90-95,共6页
Objective To evaluate the clinical efficacy of an adaptive vestibular rehabilitation training system based on Virtual Reality(VR)technology for patients with semicircular canal injury.Methods A randomized controlled t... Objective To evaluate the clinical efficacy of an adaptive vestibular rehabilitation training system based on Virtual Reality(VR)technology for patients with semicircular canal injury.Methods A randomized controlled trial was conducted with 60 patients diagnosed with peripheral vestibular vertigo.Participants were randomly assigned to either an Intervention Group(n=30),which received VR-based adaptive vestibular rehabilitation using the PICO 4 Pro system,or a Control Group(n=30),which underwent traditional vestibular rehabilitation.Both groups received training for four weeks.The primary outcome measure was the Dizziness Handicap Inventory(DHI).Secondary outcomes included balance performance assessed via the Activities-specific Balance Confidence(ABC)Scale and static posturography(Maximum Sway Path Length and Sway Area).Vestibular function was objectively evaluated using the Video Head Impulse Test(vHIT)and the Bithermal Caloric Test.Psychological status was assessed using the Hospital Anxiety and Depression Scale(HADS).Results Post-intervention analysis revealed that the Intervention Group achieved significantly lower DHI scores compared to the Control Group.In terms of balance,the Intervention Group demonstrated significantly higher ABC Scale scores and reduced Maximum Sway Path Length and Sway Area compared to controls.Furthermore,the Intervention Group showed a significantly lower rate of abnormal findings in both vHIT and Bithermal Caloric Tests,indicating improved physiological function.Improvements in psychological well-being were also observed,with the Intervention Group exhibiting significantly lower HADS scores.Conclusion VR-based adaptive vestibular rehabilitation is effective in alleviating vertigo symptoms,enhancing balance function,and improving psychological well-being.The intervention also promotes the physiological recovery of semicircular canal function,demonstrating superior clinical efficacy compared to traditional rehabilitation methods. 展开更多
关键词 vertigo vestibular rehabilitation virtual reality damage to semicircular canals
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Revealing the potential geographic convergence of global water scarcity risk and virtual water trade inequality:A three-module integrated analytical approach 认领 引用
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作者 Qiting Zuo Zhizhuo Zhang +2 位作者 Junxia Ma Qingsong Wu Yihu Ji 《Geography and Sustainability》 CSCD 2026年第1期141-154,共14页
Unequal virtual water transfer may aggravate local water scarcity risk.However,the quantitative confirmation of a clear geographic convergence between virtual water transfer and water scarcity risk remains undetermine... Unequal virtual water transfer may aggravate local water scarcity risk.However,the quantitative confirmation of a clear geographic convergence between virtual water transfer and water scarcity risk remains undetermined.We present an analytical framework that reveals the spatial matching between global water scarcity risk and virtual water trade inequality.This framework integrates a three-dimensional water scarcity risk assessment,hybrid input-output analysis,pollution trade term construction,and geographic convergence identification.The framework is applied to 123 countries for long-term validation from 1991 to 2021.We show that despite global improvements in water efficiency and security,countries exceeding the maximum water vulnerability threshold have increased by 50%.South Asia is the largest net exporter of virtual water.Central Asia exhibits the most pronounced virtual water trade inequality.To achieve the same economic growth,Central Asia needs to pay several times the local water consumption costs of developed regions(15.9−83.6 times,2021).In the past 30 years,the average geographic convergence index exceeded 0.8.Countries facing severe water scarcity also exhibit pronounced inequalities in virtual water trade,indicating that a significant geographic convergence relationship exists.Effectively responding to this unsustainable relationship necessitates balancing both domestic resource risk management and global virtual water trade regulation. 展开更多
关键词 Water scarcity risk Virtual water transfer Global inequity Geographic convergence Water resources management
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Research on cooperative operation optimization of Nash-Stackelberg game in multiple virtual power plants under multiple uncertainties 认领 引用
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作者 Lei Dong Shuaibo Zhang +4 位作者 Yang Li Zibo Wang Binwen Zhang Hong Zhu Wenlu Ji 《Global Energy Interconnection》 EI CSCD 2026年第1期186-207,共22页
This paper suggests a way to improve teamwork and reduce uncertainties in operations by using a game theory approach involving multiple virtual power plants(VPP).A generalized credibility-based fuzzy chance constraint... This paper suggests a way to improve teamwork and reduce uncertainties in operations by using a game theory approach involving multiple virtual power plants(VPP).A generalized credibility-based fuzzy chance constraint programming approach is adopted to address uncertainties stemming from renewable generation and load demand within individual VPPs,while robust optimization techniques manage electricity and thermal price volatilities.Building upon this foundation,a hierarchical Nash-Stackelberg game model is established across multiple VPPs.Within each VPP,a Stackelberg game resolves the strategic interaction between the operator and photovoltaic prosumers(PVP).Among VPPs,a cooperative Nash bargaining model coordinates alliance formation.The problem is decomposed into two subproblems:maximizing coalitional benefits,and allocating cooperative surpluses via payment bargaining,solved distributively using the alternating direction method of multipliers(ADMM).Case studies demonstrate that the proposed strategy significantly enhances the economic efficiency and uncertainty resilience of multi-VPP alliances. 展开更多
关键词 Virtual power plant Fuzzy chance constraint Generalized credibility Robust optimization Nash-Stackelberg game Nash Bargaining
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AgeStyle:Dynamic age-guided motion transfer in virtual reality 认领 引用
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作者 Feng ZHOU Chao LIU +2 位作者 Yiqing HUANG Ju DAI Senzhe XU 《虚拟现实与智能硬件（中英文）》 EI CSCD 2026年第3期283-300,共18页
Age significantly influences human motor patterns,yet existing virtual reality(VR)systems lack dynamic modelling of these variations.This paper introduces AgeStyle,a versatile framework that integrates age-guided styl... Age significantly influences human motor patterns,yet existing virtual reality(VR)systems lack dynamic modelling of these variations.This paper introduces AgeStyle,a versatile framework that integrates age-guided style selection with motion style transfer to convert user-uploaded videos into interactive 3D motion models.Utilizing 2D joint detection and 3D pose estimation,AgeStyle constructs motion representations enhanced by a CLIP-driven Cross-Attention module,capturing the distinct traits of different age groups—child flexibility,adult efficiency,and elderly stability.Our system enables real-time switching between motion styles and perspectives through voice commands,offering an immersive exploration of age-related movements.Quantitative experiments on the XIA dataset demonstrate AgeStyle’s competitive performance in both content preservation and style consistency,achieving average CC and SC++scores of 7.4 and 14.8,respectively.AgeStyle represents a meaningful advancement in VR character design,with broad potential applications in education,healthcare,rehabilitation,and interactive entertainment.For the demo,please refer to http://gffzz6712f30e645c4b03sx9pbnbcvb5qv6wk5.ffgz.tsg.suse.edu.cn/eo7Shy0Ukps.The source code of AgeStyle is available at http://gffzz188fe103f8f1460asx9pbnbcvb5qv6wk5.ffgz.tsg.suse.edu.cn/codeozzz/ageStyle. 展开更多
关键词 Style transfer Virtual reality Motion analysis Stylized motion
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Dynamic virtual power plants:A comprehensive review of architectures,control strategies,and grid support capabilities 认领 引用
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作者 Navid Vafamand Abbas Rabiee Innocent Kamwa 《iEnergy》 EI 2026年第1期7-21,共15页
The increasing penetration of inverter-based resources(IBRs)and renewable energy resources poses significant challenges to the stability and controllability of modern power systems.Dynamic virtual power plants(DVPPs)h... The increasing penetration of inverter-based resources(IBRs)and renewable energy resources poses significant challenges to the stability and controllability of modern power systems.Dynamic virtual power plants(DVPPs)have emerged as a transformative solution for aggregating and controlling heterogeneously distributed energy resources(DERs)flexibly and dynamically.This paper presents a comprehensive review of DVPPs,covering their conceptual evolution—from microgrids to virtual power plants(VPPs)and fast-acting VPPs—culminating in the dynamic DVPP paradigm.This review explores key architectural frameworks,including grid-forming and grid-following roles,as well as AC/DC interfacing strategies.Emphasis is placed on secondary frequency and voltage control mechanisms,dynamic-based and market-based disaggregation,and control methodologies tailored to DERs. 展开更多
关键词 Dynamic virtual power plants(DVPPs) Inverter-based resources(IBRs) Distributed energy resources(DERs) Disaggregation techniques Control of DERs
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Bridging the gap:Virtual psychiatric transition of care from acute to outpatient settings 认领 引用
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作者 Jason Roberge Nicole Blair +2 位作者 Alyssa Hajjar John Waller Oleg V Tcheremissine 《World Journal of Psychiatry》 SCIE 2026年第7期454-461,共8页
BACKGROUND Timely and successful transition to outpatient care following inpatient behavioral health treatment or emergency department discharge is critical to reducing suicide risk and preventing mental health deteri... BACKGROUND Timely and successful transition to outpatient care following inpatient behavioral health treatment or emergency department discharge is critical to reducing suicide risk and preventing mental health deterioration.To address this,the virtual psychiatric transition of care(VPTC)program was developed by the Department of Psychiatry at Atrium Health.AIM To provide virtual,multidisciplinary support to patient’s post-discharge,facilitating access to appropriate outpatient services.METHODS Patients enrolled between August 2021 and August 2023 were included in a retrospective evaluation of the VPTC program’s implementation.The program provided support across six inpatient Behavioral Health facilities,a Department of Behavioral Health Emergency with an Observation Unit,and a Consult Liaison Unit.All participating sites operate within a single,large,fully integrated healthcare system located in the southeastern United States.Outcomes include compliance with follow-up care,acute care utilization,and patient well-being.RESULTS Over 1500 patients were supported,with 205 follow-up visits completed through VPTC,including 84 hospital follow-ups.The hospital follow-up rate of 63%exceeded both the national average(40%-50%)and comparable internal benchmarks(37%).The program also surpassed targets for reducing symptoms of depression and anxiety,while patients reported high satisfaction,citing convenience,privacy,and ease of access.CONCLUSION The VPTC program is feasible and has shown early positive effects in supporting continuity of care and reducing acute service use.A virtual program can address patient well-being and potentially drive reductions in avoidable utilization of high-cost services.This program is a model for promoting recovery and supporting patients in navigating their transition to community-based behavioral health care. 展开更多
关键词 Virtual psychiatric transition of care Virtual care Behavioral health Telepsychiatry Post-discharge support Care coordination,Mental health services
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The use of virtual reality in cancer patient health education:A scoping review 认领 引用 被引量：1
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作者 Fangping Chen Xingyue Guo +5 位作者 Dingyuan Wei Mengxing Wang Jiayan Wang Didi Xu Luyang Jin Xuemei Xian 《International Journal of Nursing Sciences》 CSCD 2026年第1期27-35,I0003,共9页
Objectives This scoping review aimed to identify and summarize the current research on virtual reality(VR)technologies used for health education in cancer patients,as well as to identify key areas of application.Metho... Objectives This scoping review aimed to identify and summarize the current research on virtual reality(VR)technologies used for health education in cancer patients,as well as to identify key areas of application.Methods In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines,a comprehensive literature search was performed across 11 electronic databases and gray literature sources from inception to 12 September 2025.Studies employing immersive VR tools to improve health education outcomes in cancer patients were included.Data extraction and thematic synthesis were conducted to map evidence regarding VR modalities,educational applications,and outcome measures.Results Twenty-eight studies met the inclusion criteria.VR was applied across four primary educational scenarios,including radiotherapy,chemotherapy,surgery,and healthy behavior(including rehabilitation,smoking cessation,and self-management).Eight distinct VR modalities were identified,namely VR videos,virtual environments,virtual environment for radiotherapy training(VERT),VR interactions,3D models,VR games,VR non-player characters(VR NPCs),and virtual libraries.Among these,VR videos(50.0%),virtual environments(46.4%),and VR interactions(28.6%)were the most frequently employed.The interventions led to significant improvements in patient knowledge,skills,attitudes,health behaviors,and psychological well-being.A clear evolution in VR educational approaches has been observed,shifting from static environmental familiarization toward interactive,gamified,and intelligence-driven experiences.Nevertheless,notable gaps remain regarding safety protocols and data privacy protections,with only a minority of studies addressing these issues.Conclusions VR technologies demonstrate considerable promise as an innovative educational tool in oncology care,enhancing patient understanding,psychological preparedness,and engagement throughout the cancer journey.Future implementation must address infrastructural,ethical,and user-centered design barriers to facilitate the scalable and sustainable integration of this approach into clinical practice. 展开更多
关键词 Health education Neoplasms Nursing Scoping review Virtual reality
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Pix2Pix-driven virtual pathology staining based on phase contrast microscopy:A low-cost strategy for rapid intraoperative assessment of breast cancer 认领 引用 被引量：1
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作者 Yunhong Li Jianbo Zhu +5 位作者 Huijie Wang Jing Pei Zichen Ling Sheng Ding Linwei Shang Jianhua Yin 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第4期114-122,共9页
Intraoperative pathological assessment requires rapid,high-quality stained sections to support surgical decisions.Currently,however,this area lacks cost-effective and rapid staining methods for intraoperative procedur... Intraoperative pathological assessment requires rapid,high-quality stained sections to support surgical decisions.Currently,however,this area lacks cost-effective and rapid staining methods for intraoperative procedures.This study integrated a low-cost phase contrast microscope(PCM)imaging and Pix2Pix Generative Adversarial Network(GAN)to take the microimages and create a virtual staining framework of intraoperative sample-frozen sections for converting label-free phase contrast images(PCIs)into H&E-stained equivalents for thefirst time.PCIs and H&Estained whole-slide images were captured from sample-frozen sections of 15 registered patients with breast cancer and compared with their autofluorescence image results.Pix2Pix and CycleGAN models were trained on these images.It's found that the Pix2Pix GAN excels in PCI and generates a clear nuclear boundary and accurate tissue structure without staining artifacts.Quantitatively,Pix2Pix model provides a higher structural similarity index(SSIM?0.57)and peak signal-to-noise ratio(PSNR?21.65)in phase contrast mode than CycleGAN in the comparison study.The virtual staining results of PCM integrated with Pix2Pix are clearly superior to those of autofluorescence with Pix2Pix,as well as with CycleGAN.Additionally,the approach offers fast processing(1.5 s/mm2T and can generate a standard WSI virtual stained section in 3 min.This low-cost virtual staining approach bypasses the cumbersome H&E staining process in conventional pathology,significantly accelerating diagnostic procedures.It's very possible and of significance for this intelligent intraoperative technology to be extended to other intraoperative pathological assessment scenarios requiring rapid histological assessment. 展开更多
关键词 Breast cancer diagnosis phase contrast microscope Pix2Pix intraoperative virtual staining
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Virtual medicine: medical AI in human health and diseases 认领 引用 被引量：1
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作者 Chen Zhang Fu-Xiao Wang +6 位作者 Xuan Tang Ji-Long Li Ning Ding Yang Hong Pei-Ran Song Long Bai Jia-Can Su 《Military Medical Research》 SCIE CAS CSCD 2026年第4期659-681,共23页
The evolution of medicine has progressed through distinct ages: from empirical observation and evidence-based practice to the current era of precision medicine. However, traditional healthcare paradigms remain constra... The evolution of medicine has progressed through distinct ages: from empirical observation and evidence-based practice to the current era of precision medicine. However, traditional healthcare paradigms remain constrained by data fragmentation, scalability limits, and the overwhelming complexity of multi-omics integration. In the rapid explosion of artificial intelligence (AI), a transformative paradigm is emerging. This review introduces the concept of “Virtual Medicine”, which is defined as a comprehensive ecosystem of AI-empowered medical practice that transcends physical limitations. This review systematically summarizes the technological foundations, historical evolution, and core applications of AI in medicine, including electronic health records (EHRs) analysis, medical imaging, multimodal diagnostics, drug discovery, precision oncology, intelligent surgery, and clinical decision support systems. It further highlights the role of medical AI in health management, public health surveillance, and healthcare delivery in resource-limited settings. Special attention is given to the transformative emergence of large language models (LLMs), such as medical large language models (MedLLM) and generative pre-trained transformer (GPT) architectures, emphasizing their potential to revolutionize virtual medical interaction, clinical reasoning, and documentation. Despite these advances, significant challenges remain regarding model transparency, data bias, fairness, and patient privacy. Overcoming these limitations necessitates standardized evaluation frameworks, interpretable algorithm designs, and strengthened privacy protections. Ultimately, these efforts aim to foster a trustworthy and equitable future for virtual medicine. 展开更多
关键词 Medical artificial intelligence(AI) Clinical decision support Virtual Medicine Precision medicine Large language models(LLMS)
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Design of Virtual Driving Test Environment for Collecting and Validating Bad Weather SiLS Data Based on Multi-Source Images Using DCU with V2X-Car Edge Cloud 认领 引用 被引量：1
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作者 Sun Park JongWon Kim 《Computers, Materials & Continua》 SCIE EI 2026年第3期448-467,共20页
In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to... In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to dangerous situations.Furthermore,autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS.Driving simulators,which replicate driving conditions nearly identical to those in the real world,can drastically reduce the time and cost required for market entry validation;consequently,they have become widely used.In this paper,we design a virtual driving test environment capable of collecting and verifying SiLS data under adverse weather conditions using multi-source images.The proposed method generates a virtual testing environment that incorporates various events,including weather,time of day,and moving objects,that cannot be easily verified in real-world autonomous driving tests.By setting up scenario-based virtual environment events,multi-source image analysis and verification using real-world DCUs(Data Concentrator Units)with V2X-Car edge cloud can effectively address risk factors that may arise in real-world situations.We tested and validated the proposed method with scenarios employing V2X communication and multi-source image analysis. 展开更多
关键词 Virtual driving test DCU bad weather SiLS autonomous environment V2X-Car edge cloud
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Equivariant graph neural network-based accurate and ultra-fast virtual screening of small molecules targeting miRNA-protein complex 认领 引用
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作者 Huabei Wang Zhimin Zhang +2 位作者 Guangyang Zhang Ming Wen Hongmei Lu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期775-786,共12页
MicroRNAs(miRNAs)are small RNA molecules with significant therapeutic potential for treating various diseases,underscoring the need for effective methods to screen drugs targeting disease-associated miRNAs.In this stu... MicroRNAs(miRNAs)are small RNA molecules with significant therapeutic potential for treating various diseases,underscoring the need for effective methods to screen drugs targeting disease-associated miRNAs.In this study,we introduce miRPVS,a rapid virtual screening approach designed to identify small molecule drugs targeting miRNA-protein complex.miRPVS identifies binding pockets on the surface of these complexes,expanding the scope of potential small molecule targets.It employs an equivariant graph neural network model to extract three-dimensional(3D)structure features of small molecules,enabling accurate prediction of docking scores.Using miRPVS,four complexes involved in primiRNA cleaving,pre-miRNA transport,and mRNA depress were identified as promising targets.For each target,hit compounds were screened from the ZINC20 database,which contains approximately 600 million drug-like small molecules.MiRPVS predicted the docking score for these compounds,with Pearson correlation coefficients between predicted and experimentally docked scores comparable to those obtained through twice docking.Notably,the average deviation was only 0.67%across the four complexes.Remarkably,the entire screening process for all four complexes was completed in 14 h using just four V100 GPUs.Additionally,we integrated AlphaFold3-predicted structures into the miRPVS workflow,enabling virtual screening of small molecules against miRNA-protein complexes without experimentally determined structures.miRPVS demonstrated performance comparable to traditional docking methods while significantly reducing computational time and resource requirements.This innovative approach holds great promise for accelerating the discovery of small molecule drugs targeting miRNA-regulated pathways,addressing a critical gap in miRNA therapeutics. 展开更多
关键词 microRNA-protein complex Deep learning Drug discovery Virtual screening
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Discovery of N-phenyl-isoindole-1,3-dione derivatives as potent insect chitinase Of Chi-h inhibitors through virtual screening 认领 引用
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作者 Jiahao Zhang Shenmeng Bai +10 位作者 Jiaxin Chu Baokang Ding Bohou Li Yanzhu Li Jingwen Guo Fengyue Suo Shujie Ma Jingao Dong Lihui Zhang Shengqiang Shen Lili Dong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第8期3341-3351,共11页
Ostrinia furnacalis represents a destructive lepidopteran pest causing up to 30%yield losses in maize crops globally.Its larvae penetrate plant tissues,disrupt nutrient transport,and transmit viral and microbial patho... Ostrinia furnacalis represents a destructive lepidopteran pest causing up to 30%yield losses in maize crops globally.Its larvae penetrate plant tissues,disrupt nutrient transport,and transmit viral and microbial pathogens,exacerbating food security concerns.Current management approaches for O.furnacalis primarily rely on synthetic pesticides.Targeting chitin metabolism presents a promising strategy for green insecticide development.Specifically,Of Chi-h,an essential chitinase for O.furnacalis molting and survival,has emerged as a viable target.This study identified a N-phenyl-isoindole-1,3-dione(PI)scaffold as a novel class of Of Chi-h inhibitor through virtual screening strategy.Notably,compound PI-17 demonstrated potent inhibitory activity against Of Chi-h with a Kivalue of 2.3μmol L-1.PI-17 exhibited significant insecticidal activity against lepidopteran pests O.furnacalis,comparable to the control drug hexaflumuron.Scanning electron microscopy(SEM)analysis revealed morphological alterations in the cuticles of O.furnacalis larvae treated with PI-series compounds.Electrostatic potential(ESP)and density functional theory(DFT)calculations explored the variations in biological activities of the PI-series compounds at atomic and electronic levels.Additionally,comprehensive safety evaluations assessed the impact on the natural enemy Trichogramma ostriniae and nontarget organisms.These findings introduce a novel class of lead compounds,PI derivatives,showing significant potential for developing eco-friendly insect growth regulators to control O.furnacalis. 展开更多
关键词 insect growth regulators chitinase inhibitors OfChi-h N-phenyl-isoindole-1 3-dione virtual screening
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Numerical calculation method of virtual nodes in complex structural composites: mechanical properties characterization and numerical simulation of combined Wbraid/Al/Epoxy functional structural materials 认领 引用
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作者 Zhenhui He Enling Tang +3 位作者 Zhe Zhai Wenjin Yao Ruizhi Wang Yafei Han 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第3期149-165,共17页
Existing numerical methods for complex composites, such as multiscale simulation and neural network algorithms, face significant limitations. Multiscale techniques are often prohibitively expensive for large models, w... Existing numerical methods for complex composites, such as multiscale simulation and neural network algorithms, face significant limitations. Multiscale techniques are often prohibitively expensive for large models, while neural networks struggle to represent underlying microscopic material properties. To overcome these challenges, a meso-micro scale numerical method using a virtual node approach is developed in this study. A Wbraid/Al/Epoxy functional structural material is fabricated, and a representative periodic unit cell is identified based on its architecture. The complex structure is then discretized into nodes, and mechanical interactions are governed by pre-defined computation rules. This virtual node method is systematically compared against both multiscale simulation and a neural network algorithm, with validation provided through mechanical experiments. The results demonstrate that the nodal operation strategy significantly reduces computational resource requirements. By quantifying microscopic bonding with coefficients, explicit interface treatment is avoided, granting the method strong adaptability to lattice materials. The method can simulate extremely complex structures using parameters from simple tests and is suited for large systems. Compared to three-point bending experiments, errors for multiscale, virtual node, and neural network methods were 12.4%, 6.9%, and 34.5%, respectively. Under dynamic compression, the errors were 2.7%, 9.3%, and 15.43%. The virtual node method demonstrated superior accuracy under static conditions, enabling efficient prediction and auxiliary development of complex structural materials. 展开更多
关键词 Functional composites Complex structure Meso-micro scale Virtual node calculation method Numerical simulation
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