OBJECTIVE:To observe the effects of the flower of Edgeworthia gardneri(Wall.)Meisn(EWM)on glucose and lipid metabolism in KK/upj-Ay/J(KKAy)mice and investigate the possible mechanism of EWM in the liver of KKAy mice b...OBJECTIVE:To observe the effects of the flower of Edgeworthia gardneri(Wall.)Meisn(EWM)on glucose and lipid metabolism in KK/upj-Ay/J(KKAy)mice and investigate the possible mechanism of EWM in the liver of KKAy mice by transcriptome analysis.METHODS:Forty KKAy mice were fed a high-sugar and high-fat diet for 3 weeks to establish the animal model of metabolic syndrome.After 5 weeks of continuous administration of EWM,serum high-density lipoprotein(HDL),low-density lipoprotein(LDL),triglycerides(TG),total cholesterol(TC),and free fatty acids(FFA)were detected by radioimmunoassay.Serum fasting insulin(Fins)and adiponectin levels were measured by enzymelinked immunosorbent assay.Liver tissue fixed with paraformaldehyde was stained with hematoxylineosin and oil red O.Transcriptome analysis was used to evaluate the liver tissue.The expressions of lipoprotein lipase(LPL),peroxisome proliferator-activated receptor-γ(PPARγ),adenosine 5‘-monophosphate-activated protein kinase(AMPK),sterol regulatory element binding protein1c(SREBP-1c),and fatty acid synthase(Fas)mRNA and protein in liver tissue were detected by reverse transcription-polymerase chain reaction(RT-PCR)and Western blot analysis.RESULTS:EWM slightly reduced FBG and Fins in KKAy mice.Furthermore,EWM was able to downregulate serum LDL,TG,TC,and FFA and upregulate the expression of serum HDL and adiponectin.Transcriptome analysis revealed the following differential pathways:the peroxisome proliferator-activated receptor(PPAR)signaling pathway and the AMPK signaling pathway.RT-PCR and western blot analysis detected the associated genes and proteins.In addition,EWM was able to upregulate the expression of AMPK and downregulate the expression of PPARγ,SREBP1c,and Fas mRNA and protein and upregulate the expression of LPL mRNA.CONCLUSIONS:EWM can alleviate lipid metabolism disorders and to some extent improve glucose metabolism disorders in KKAy mice.These effects may be related to regulating PPARγ/LPL and activating the AMPK/SREBP1c/Fas pathway.展开更多
[Objective] This research aimed to establish an inductively coupled plasma mass spectrometry (ICP-MS) method for determination of five kinds of heavy metals (Pb, Cd, Cu, As and Hg) in Dendrobium candidium Wall. ex...[Objective] This research aimed to establish an inductively coupled plasma mass spectrometry (ICP-MS) method for determination of five kinds of heavy metals (Pb, Cd, Cu, As and Hg) in Dendrobium candidium Wall. ex Lindl. [Method] The samples were digested in HNO3-H202 acids system by closed vessel microwave di- gestion. At the same time, internal standard was added to avoid the matrix effect. [Result] The five kinds of heavy meals all showed good linear relationships, and the correlation coefficients ranged from 0.998 2 to 0.999 9. The detection limits of the five kinds of heavy metals were in the range of 0.008-0.750 μg/L, while the stan- dard recovery rates were in the range of 90.4%-96.9%. The relative standard devi- ations ranged from 1.6% to 8.2%. The heavy metals in the Ginseng and Astragalus national standard samples were determined by the established ICP-MS method, and the results were in conformity with the standard values. [Conclusion] The established method has simple and convenient operation and accurate and reliable results, and it meets the requirements by determination of heavy metals in Dendrobium candididium Wall. ex Lindl.展开更多
[Objectives]To investigate the anti-inflammatory effect of Embelia parviflora Wall.polysaccharide on rheumatoid arthritis(RA)in rats.[Methods]RA rat model was induced by type II collagen.After successful modeling,the ...[Objectives]To investigate the anti-inflammatory effect of Embelia parviflora Wall.polysaccharide on rheumatoid arthritis(RA)in rats.[Methods]RA rat model was induced by type II collagen.After successful modeling,the rats were divided into model group,positive group,low,medium and high dose of E.parviflora Wall.polysaccharide groups,and normal control group.Body mass,toe volume and arthritis index were measured,and thymus index and spleen index were calculated.The levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin serum and synovial tissue of ankle joint were detected by ELISA.[Results]Compared with the normal control group,the pathological changes such as synovial hyperplasia and unclear layer were observed in the model group,the body mass was decreased(P0.05).[Conclusions]E.parviflora Wall.polysaccharide can reduce the body's inflammatory response and improve RA,which may be related to the inhibition of the activation of inflammatory cytokines IL-1β,IL-6 and TNF-α.展开更多
[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) ch...[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) chromatographic column was adopted,and the mobile phase was acetonitrile-0. 1% phosphoric acid aqueous solution for gradient elution,the detection wavelength was 328 nm,the column temperature was 25 ℃,the similarities of 18 different batches of medicinal materials were evaluated,and the HPLC fingerprint chromatogram of S. paniculata Wall. ex DC. was set up. [Results] The RSDs of precision,repeatability and stability of HPLC fingerprint of 18 batches of S. paniculata Wall. ex DC. medicine materials were all less than 3%;HPLC reference fingerprint of the medicine materials was established.[Conclusions]HPLC fingerprint was established,its data were stable and reliable,and the method was simple and efficient,which could provide reference for the quality evaluation of Zhuang medicine S. paniculata Wall. ex DC.展开更多
[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to pro...[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora.展开更多
Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been use...Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier times.The medicinal uses of Delphinium denudatum Wall.date back to over 1,000 years ago.Rhazes(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum Wall.as a herbal remedy.During the following centuries,the usages of Delphinium denudatum Wall.in the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and poisoning.According to modern studies,the dried roots of Delphinium denudatum Wall.have antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving properties.Biomolecules from roots of Delphinium denudatum Wall.were also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine addiction.Delphinium denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory disorders.The effective therapeutic influence of root extract of Delphinium denudatum Wall.against several diseases needs to be confirmed through controlled clinical trials.This article reviews the different features of Delphinium denudatum Wall.and focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.展开更多
Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhiz...Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhizome for medicine and habitat destruction. The species has very poor adaptive power to the synthetic environment and fails to grow and propagate. Present study was undertaken to develop suitable low cost propagation technique and produce clonal planting materials through rhizome splitting and root cutting. Rhizomes and roots were cut into segments and sowed in the raised soil bed prepared by mixing decayed wood powder, sand and top black soil at 1:1:3 ratios in a shaded poly house. Of the sowed rhizome segments ~55% segments remained recalcitrant to morphogenetic response in the first year of the study and the response improved in the subsequent years. In the third year ~51% rhizome segments responded positively. The horizontal root cuts mostly remained morphogenetically dormant but inclined root cuts exhibited better response. The morphogenetic response from the roots was comparatively very poor compare to rhizome segments. The plantlets formed both rhizome segments and root cuttings were maintained for three years in the bed/pots followed by transferring in the cultivated plots.展开更多
[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata(Wall.)Moq.and evaluate its antioxidant capacity in vitro.[Methods]The single factor orthogonal design was ap...[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata(Wall.)Moq.and evaluate its antioxidant capacity in vitro.[Methods]The single factor orthogonal design was applied to explore the effects of ultrasonic time,solid-to-liquid ratio,extraction time and ethanol precipitation concentration on the extraction rate of crude polysaccharides from C.Capitata,to obtain the optimal extraction process;DPPH and ABTS^+free radical scavenging ability was detected to evaluate its in vitro antioxidant activity.[Results]The optimal extraction process of C.Capitata crude polysaccharide was as follows:solid-to-liquid ratio was 40∶1,the extraction temperature was 50℃,the ultrasonic time was 80 min.Under such conditions,the extraction rate of C.Capitata crude polysaccharide was 10.51%,and the purity was 56.9%;C.Capitata crude polysaccharide has good scavenging ability to DPPH and ABTS^+free radicals,and its IC50values are 0.468 and 0.231 mg/mL,respectively.[Conclusions]The optimized process is simple and feasible,and the C.Capitata polysaccharide has good antioxidant activity in vitro.This experiment provides a basis for the further development and utilization of the C.Capitata polysaccharide.展开更多
[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chrom...[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chromatography and other modern separation methods and techniques were used to separate and purify the chemical components of the ethyl acetate fraction of the fruit of E.undulata(Wall.)Mez,and based on the physical and chemical properties and spectral data,their structure was identified.[Results]Six compounds were isolated from the fruit of E.undulata(Wall.)Mez,including trimethyl citrate(1),vanillic acid(2),5-hydroxymethylfurfural(3),1,5-dimethyl citrate(4),1,6-dimethyl-5-ethyl citrate(5)and 3,4-dihydroxybenzoic acid(6).[Conclusions]Compounds 1-6 are all isolated from E.undulata(Wall.)Mez for the first time.展开更多
Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D. sandidium Wall. et Lindl. could grow at temperature 5 -35 ℃and pH v...Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D. sandidium Wall. et Lindl. could grow at temperature 5 -35 ℃and pH value of 2 - 10, the optimal temperature and pH value were 25℃ and 7 for its growth and sporulation, respectively. Starch was the optimal carbon sources and peptone was the optimal nitrogen source for the growth and sporulation of bacterial colony, re- spectively; PSA and PCA were the optimal media for its growth and sporalation, respectively.展开更多
[Objectives] In order to develop Triplostegia glandulifera Wall.ex DC. into foromula granules, a high performance liquid chromatography (HPLC) determination method and a TLC identification method for loganic acid in d...[Objectives] In order to develop Triplostegia glandulifera Wall.ex DC. into foromula granules, a high performance liquid chromatography (HPLC) determination method and a TLC identification method for loganic acid in decoction pieces, standard decoction and formula granules of T. glandulifera were established, and the quantity value transfer relationship of T. glandulifera pieces-standard decoction-formula granules was investigated.[Methods] An Agilent 1260 II high performance liquid chromatograph and a Waters Symmetry C18 column (4.6 mm×250 mm, 5 μm) were used to perform gradient elution with acetonitrile-0.1%phosphoric acid solution as the mobile phase at a column temperature of 30 ℃ and a flow rate of 1 mL/min, and the detection wavelength was 240 nm. The TLC identification method of T. glandulifera was established using ethyl acetate-methanol-water (10 : 2 : 1) as the developer, and examination was carried out under a UV lamp (254 nm). The quantity value transfer law was analyzed by using the extract yield, the content of loganic acid and TLC chromatograms as the main evaluation indexes.[Results] The method for the determination and identification of loganic acid is stable, reproducible and reliable. The average yield, average loganic acid content and average loganic acid content transfer rate of 3 batches of T. glandulifera formula granules were, respectively, 18.7%, 41.1 mg/g and 43.1%, each of which was within corresponding range of mean±3SD of the 15 batches of standard decoction.[Conclusions] The content determination and TLC identification methods of loganic acid can be used to evaluate the quality of T. glandulifera formula granules. This study provides data basis for further research on T. glandulifera formula granules, and promotes the modernization of medicines for ethnic minorities.展开更多
In this study,the dynamic characteristics of microscale floating bubbles near the vertical wall are studied.This occurrence is common in industrial and natural phenomena.Although many studies have been conducted on mi...In this study,the dynamic characteristics of microscale floating bubbles near the vertical wall are studied.This occurrence is common in industrial and natural phenomena.Although many studies have been conducted on microscale bubbles,few studies investigate floating bubbles with very small Reynolds number(Re)near the wall,which is the main research goal of this study.Therefore,this study establishes a model for the ascent of small-scale bubbles near a vertical wall using the interFoam solver in OpenFOAM.This study investigates the influences of diverse viscosity parameters,varying distances from the wall,and different gas flow rates on the terminal velocity,deformation,and motion trajectory of bubbles.The results reveal that as liquid viscosity increases,the Re of bubbles gradually decreases and reaches a minimum of 0.012,which is similar to the Re of micrometer-sized bubbles in water.The characteristics of the wall-induced force in the longitudinal direction are closely related to the changes in liquid viscosity.Under low-viscosity conditions,the induced lift is the principal form of action,whereas under high-viscosity conditions,it is primarily manifested as induced drag.展开更多
During the construction of underground caverns,the rock masses of intermediate wall between closelyspaced caverns are easy to be destroyed due to excessive blast-induced damage.Limited to the current measurement techn...During the construction of underground caverns,the rock masses of intermediate wall between closelyspaced caverns are easy to be destroyed due to excessive blast-induced damage.Limited to the current measurement technology,we cannot achieve rapid assessment of the rock damage,making it difficult to realize real-time adjustments to the blast design.Given that the blast vibration is relatively easy to acquire,the study establishes a correlation between the peak particle velocity(PPV)and the damage depth within the intermediate wall.A field measurement of the blast vibration was conducted in a scenario of excavating closely-spaced caverns.A dynamic finite element model was thereafter established and loaded via the equivalent elastic boundary(EEB)method.The model was verified based on the measurement data of blast vibration,together with an appropriate load amplification coefficient.Then,a series of small dimensional models with single-borehole were created to obtain the rock damage extent under various charge quantity in the near-blast area,while a large dimensional EEB model was applied to capture the PPV distribution in the far-field of blasting under the corresponding charge quantities.Finally,the blast-induced damage depth of the intermediate wall and the PPV at a certain blast center distance were correlated by the charge quantity.The relationships between PPV and damage depth at different blast center distance were fitted.The results indicate that deploying vibration monitoring at about 40 m or 50 m from the blasting face can estimate in advance the damage depth of intermediate wall,which can help provide some guidance to the blast of closely-spaced caverns.展开更多
Recovering palladium(Pd)from low-concentration metallurgical wastewater still poses significant challenges.In this study,triaminoguanidine hydrochloride was used as the key functional site,and three guanidine-function...Recovering palladium(Pd)from low-concentration metallurgical wastewater still poses significant challenges.In this study,triaminoguanidine hydrochloride was used as the key functional site,and three guanidine-functionalized covalent organic frameworks(GCOFs)were successfully constructed by adjusting the substituents(-H,-OH,and-OCH3)on terephthalaldehyde molecules,and their extraction performance towards palladium was explored.First,multiple characterization techniques,including scanning electron microscopy,zeta potential analysis,and contact angle measurement,were employed to systematically investigate the regulatory rules of substituents on the physicochemical properties of GCOFs,such as their micromorphology,surface potential,and hydrophilicity.Second,static adsorption experiments were conducted to systematically study the adsorption behavior of GCOFs with different substituents toward Pd(Ⅱ),and the maximum sorption capacity of COF-H is up to 180 mg g-1.Furthermore,this study successfully fabricated GCOFs into aerogels by means of freeze-drying technology and conducted dynamic adsorption experiments with actual metallurgical wastewater.Specifically,70.0 mg of COF-H/aerogel is capable of continuously treating 12.5 L of metallurgical wastewater.In conclusion,by regulating the types of substituents,this study clarified the influence rules of substituent effects on the Pd(Ⅱ)adsorption performance of GCOFs in metallurgical wastewater.The developed GCOFs/aerogels hold broad application potential in the fields of precious metal resource recovery and environmental protection.展开更多
To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation ra...To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation rate initially increased during HT(0-8 d),but subsequently decreased,resulting in a significant decrease in cotton fiber length at harvest.At 3 and 6 d under HT,cell turgor pressure increased;additionally,the auxin and ethylene content in fiber significantly increased,promoting cell wall loosening and increasing elongation rate through regulating xyloglucan endoglycosyltransferases/hydrolases and expansin.At 12 d under HT,cellulose and hemicellulose decomposition were inhibited in fiber,which hindered cell wall loosening and restricted fiber elongation.Meanwhile,the lipid and callose content in fiber was increased,and the enhanced abscisic acid and H2O2content promoted lignin synthesis by up-regulating the expression of WLIM1a gene.Both changes accelerated the initiation of secondary wall synthesis.Consequently,the transition stage that coincides with fiber elongation and secondary wall thickening was reduced by 0.3-0.5 d,leading to a decrease in fiber length.In summary,fiber length was reduced under HT,accompanied by restricted cell wall loosening and accelerated secondary wall synthesis.展开更多
The deformation and failure of coal walls in front of a working face cause significant difficulties during mining operations.This study reveals the nonuniform distribution of bearing pressure in front of coal walls ba...The deformation and failure of coal walls in front of a working face cause significant difficulties during mining operations.This study reveals the nonuniform distribution of bearing pressure in front of coal walls based on in situ monitoring data and numerical simulation.Therefore,an eccentric compression mechanical model was established to study the deformation and failure characteristics of a coal wall.The slenderness ratio of the compression bar is introduced to define coal walls.The results showed that instability failure occurs when λ>λc and material failure occurs when λ≤λc.The instability failure-type coal wall spalling was related to the mining height,eccentricity of roof pressure,the horizontal force,and the reaction moment of the floor.The material failure-type coal wall spalling was related to the cohesion,the internal friction angle of the coal,the upper pressure,and the horizontal force of coal walls.Unstable and destructive coal wall peeling usually occurs at a height of 0.5–0.6 times the mining height,while material damage to coal wall peeling is determined to occur within the range of 0.4-0.6 times the mining depth.The findings contribute to the understanding of the deformation and failure of coal walls.展开更多
Excavation-induced retaining wall deflection(RWD)significantly influences the safety of surrounding built environment.To predict the three-dimensional RWD in heterogeneous strata,a new partial differential equation(PD...Excavation-induced retaining wall deflection(RWD)significantly influences the safety of surrounding built environment.To predict the three-dimensional RWD in heterogeneous strata,a new partial differential equation(PDE)is derived in this study,and two prediction models are proposed,i.e.the physics-informed neural network(PINN)model and the data-driven PINN model.As a physical constraint,the new PDE is crucial to the loss functions of these models.Then,the validity of the models is verified and analysed using a subway deep-foundation pit.The results show that the training times of both models are controlled within 900 s,which is a significant reduction compared to that of the conventional numerical model.In addition,the prediction accuracy of the data-driven PINN model is higher than that of the numerical model,while that of the PINN model is slightly lower than that of the numerical simulation.However,in contrast to the data-driven PINN model,the PINN model can identify irregular soil interfaces in heterogeneous strata to learn the deflection continuity conditions at irregular interfaces and realize RWD prediction in non-uniform distributed strata.In practical applications in foundation pit engineering,the selection of the PINN and data-driven PINN models can be conducted according to the in situ distribution conditions of the strata to enable the early prediction of potential RWD,thereby providing a reliable basis for the further optimisation of retaining structures design.展开更多
Spherical and capsule-shaped surface tension tanks are widely used in satellite,spacecraft,and other fields due to their advantages of lightweight structure,high efficiency,and high reliability.With the advancement of...Spherical and capsule-shaped surface tension tanks are widely used in satellite,spacecraft,and other fields due to their advantages of lightweight structure,high efficiency,and high reliability.With the advancement of space exploration,the demands for thinner walls,more complex structures,and uniform overall performance in the hemispherical shells of these tanks present significant challenges for hemispherical shell forming technique.A hemispherical shell with uniform wall thickness was prepared using the rapid direct-and-reverse superplastic forming method.Results reveal that the properties and microstructure of each section of the formed hemisphere shell are consistent with those of the initial plate,and the overall shell thickness is highly uniform.展开更多
The negative pressure near-wall particle collection method employs suction flow to circulate the medium along the inner wall of the collection port,creating flow separation that affects flow characteristics and partic...The negative pressure near-wall particle collection method employs suction flow to circulate the medium along the inner wall of the collection port,creating flow separation that affects flow characteristics and particle forces.This investigation utilizes a CFD simulation method,validated through Zhao’s experiments,and implements a“circular pipe suction model”to examine how collection port parameters-specifically wall thickness and shape-influence the flow field and particle collection efficiency across different Reynolds numbers.The findings demonstrate that wall thickness and port shape substantially affect flow separation,as evidenced by recirculation zones that compress the flow and modify the particle force coefficient.Typically,greater wall thickness results in decreased particle force coefficients,with variations up to 15%.Moreover,collection ports with inward-pointing sharp angles demonstrate the highest particle force coefficients,while those with outward-pointing angles show the lowest,exhibiting variations up to 23%.These results indicate that optimizing collection port design through wall thickness and shape modifications can improve particle collection efficiency,enhancing practical applications.展开更多
In the past decade,the discovery of robust ferroelectricity in scandium-doped aluminum nitride(Al1−xScxN)[1]has ignited a new wave of research in the semiconductor community.Unlike traditional perovskite ferroel...In the past decade,the discovery of robust ferroelectricity in scandium-doped aluminum nitride(Al1−xScxN)[1]has ignited a new wave of research in the semiconductor community.Unlike traditional perovskite ferroelectrics(such as PbZrTiO3 or PZT)[2],wurtzite-structured materials are fully compatible with modern CMOS fabrication processes[3].展开更多
基金Supported by the Key Laboratory of TCM Health Cultivation of Beijing(grant No.BZ0259)the Creation and Talent Introduction Base of Prevention and Treatment of Diabetes and Its Complications with Traditional Chinese Medicine(No.B20055)。
摘要OBJECTIVE:To observe the effects of the flower of Edgeworthia gardneri(Wall.)Meisn(EWM)on glucose and lipid metabolism in KK/upj-Ay/J(KKAy)mice and investigate the possible mechanism of EWM in the liver of KKAy mice by transcriptome analysis.METHODS:Forty KKAy mice were fed a high-sugar and high-fat diet for 3 weeks to establish the animal model of metabolic syndrome.After 5 weeks of continuous administration of EWM,serum high-density lipoprotein(HDL),low-density lipoprotein(LDL),triglycerides(TG),total cholesterol(TC),and free fatty acids(FFA)were detected by radioimmunoassay.Serum fasting insulin(Fins)and adiponectin levels were measured by enzymelinked immunosorbent assay.Liver tissue fixed with paraformaldehyde was stained with hematoxylineosin and oil red O.Transcriptome analysis was used to evaluate the liver tissue.The expressions of lipoprotein lipase(LPL),peroxisome proliferator-activated receptor-γ(PPARγ),adenosine 5‘-monophosphate-activated protein kinase(AMPK),sterol regulatory element binding protein1c(SREBP-1c),and fatty acid synthase(Fas)mRNA and protein in liver tissue were detected by reverse transcription-polymerase chain reaction(RT-PCR)and Western blot analysis.RESULTS:EWM slightly reduced FBG and Fins in KKAy mice.Furthermore,EWM was able to downregulate serum LDL,TG,TC,and FFA and upregulate the expression of serum HDL and adiponectin.Transcriptome analysis revealed the following differential pathways:the peroxisome proliferator-activated receptor(PPAR)signaling pathway and the AMPK signaling pathway.RT-PCR and western blot analysis detected the associated genes and proteins.In addition,EWM was able to upregulate the expression of AMPK and downregulate the expression of PPARγ,SREBP1c,and Fas mRNA and protein and upregulate the expression of LPL mRNA.CONCLUSIONS:EWM can alleviate lipid metabolism disorders and to some extent improve glucose metabolism disorders in KKAy mice.These effects may be related to regulating PPARγ/LPL and activating the AMPK/SREBP1c/Fas pathway.
摘要[Objective] This research aimed to establish an inductively coupled plasma mass spectrometry (ICP-MS) method for determination of five kinds of heavy metals (Pb, Cd, Cu, As and Hg) in Dendrobium candidium Wall. ex Lindl. [Method] The samples were digested in HNO3-H202 acids system by closed vessel microwave di- gestion. At the same time, internal standard was added to avoid the matrix effect. [Result] The five kinds of heavy meals all showed good linear relationships, and the correlation coefficients ranged from 0.998 2 to 0.999 9. The detection limits of the five kinds of heavy metals were in the range of 0.008-0.750 μg/L, while the stan- dard recovery rates were in the range of 90.4%-96.9%. The relative standard devi- ations ranged from 1.6% to 8.2%. The heavy metals in the Ginseng and Astragalus national standard samples were determined by the established ICP-MS method, and the results were in conformity with the standard values. [Conclusion] The established method has simple and convenient operation and accurate and reliable results, and it meets the requirements by determination of heavy metals in Dendrobium candididium Wall. ex Lindl.
基金Supported by State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine-Ethnic Minority Pharmacy (Zhuang Pharmacy) (zyyzdxk-2023165)Young Talent Cultivation Program of Guangxi International Zhuang Medicine Hospital (2022001)+4 种基金Key R&D Project of Guangxi Science and Technology Department (Guike AB21196057)Guangxi Traditional Chinese Medicine Interdisciplinary Innovation Team Project (GZKJ2309)Funding Project of High-level Talent Cultivation and Innovation Team of Guangxi University of Chinese Medicine (2022A008)The Third Batch of"Qihuang Project"High-Level Talent Team Training Project of Guangxi University of Chinese Medicine (202414)Three-year Action Plan for the Construction of High-level Talents Team of Guangxi International Zhuang Medicine Hospital in 2023 (GZCX20231203).
摘要[Objectives]To investigate the anti-inflammatory effect of Embelia parviflora Wall.polysaccharide on rheumatoid arthritis(RA)in rats.[Methods]RA rat model was induced by type II collagen.After successful modeling,the rats were divided into model group,positive group,low,medium and high dose of E.parviflora Wall.polysaccharide groups,and normal control group.Body mass,toe volume and arthritis index were measured,and thymus index and spleen index were calculated.The levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin serum and synovial tissue of ankle joint were detected by ELISA.[Results]Compared with the normal control group,the pathological changes such as synovial hyperplasia and unclear layer were observed in the model group,the body mass was decreased(P0.05).[Conclusions]E.parviflora Wall.polysaccharide can reduce the body's inflammatory response and improve RA,which may be related to the inhibition of the activation of inflammatory cytokines IL-1β,IL-6 and TNF-α.
基金Supported by"Collaborative Innovation Center in Guangxi in 2011-Study on Fingerprint of Three Kinds of Zhuang Medicine:Gynura crepidioides Benth.,Spilanthes paniculata Wall. ex DC.Lindernia ruellioides(Colsm)Pennell.,Program of Guangxi Scientific Research and Technology Development(Gui Ke Chong 1598005-10)+3 种基金Zhuang Yao Medicine Collaborative Innovation Center(No.20,Gui Jiao Ke Yan[2013])Guangxi Zhuang Yao Medicine Key Laboratory(No.32,Gui Ke Ji Zi[2014])Guangxi Zhuang Pharmacy Key Discipline(No.16,Gui Jiao Ke Yan[2013])Research on the Innovation Theory and Pharmacodynamics of Traditional Chinese Medicine by Guangxi Bagui Scholars(J13162)
摘要[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) chromatographic column was adopted,and the mobile phase was acetonitrile-0. 1% phosphoric acid aqueous solution for gradient elution,the detection wavelength was 328 nm,the column temperature was 25 ℃,the similarities of 18 different batches of medicinal materials were evaluated,and the HPLC fingerprint chromatogram of S. paniculata Wall. ex DC. was set up. [Results] The RSDs of precision,repeatability and stability of HPLC fingerprint of 18 batches of S. paniculata Wall. ex DC. medicine materials were all less than 3%;HPLC reference fingerprint of the medicine materials was established.[Conclusions]HPLC fingerprint was established,its data were stable and reliable,and the method was simple and efficient,which could provide reference for the quality evaluation of Zhuang medicine S. paniculata Wall. ex DC.
基金National Natural Science Foundation of China(81660701)Natural Science Foundation of Guangxi(2016GXNSFAA380148)+1 种基金Scientific Research Innovation Program of Guangxi University of Chinese Medicine(YJSZ201712)Program of Key Laboratory for Purification and Quality Analysis of TCM Extraction in Guangxi Universities(Gui Jiao Ke Yan[2014]No.6).
摘要[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora.
摘要Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier times.The medicinal uses of Delphinium denudatum Wall.date back to over 1,000 years ago.Rhazes(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum Wall.as a herbal remedy.During the following centuries,the usages of Delphinium denudatum Wall.in the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and poisoning.According to modern studies,the dried roots of Delphinium denudatum Wall.have antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving properties.Biomolecules from roots of Delphinium denudatum Wall.were also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine addiction.Delphinium denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory disorders.The effective therapeutic influence of root extract of Delphinium denudatum Wall.against several diseases needs to be confirmed through controlled clinical trials.This article reviews the different features of Delphinium denudatum Wall.and focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.
摘要Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhizome for medicine and habitat destruction. The species has very poor adaptive power to the synthetic environment and fails to grow and propagate. Present study was undertaken to develop suitable low cost propagation technique and produce clonal planting materials through rhizome splitting and root cutting. Rhizomes and roots were cut into segments and sowed in the raised soil bed prepared by mixing decayed wood powder, sand and top black soil at 1:1:3 ratios in a shaded poly house. Of the sowed rhizome segments ~55% segments remained recalcitrant to morphogenetic response in the first year of the study and the response improved in the subsequent years. In the third year ~51% rhizome segments responded positively. The horizontal root cuts mostly remained morphogenetically dormant but inclined root cuts exhibited better response. The morphogenetic response from the roots was comparatively very poor compare to rhizome segments. The plantlets formed both rhizome segments and root cuttings were maintained for three years in the bed/pots followed by transferring in the cultivated plots.
基金Supported by Open Fund Project of Key Laboratory of Higher Education in Sichuan Province in 2017 for Development of Characteristic Biological Resources in Dry and Hot Valley(GR-2017-C-01)
摘要[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata(Wall.)Moq.and evaluate its antioxidant capacity in vitro.[Methods]The single factor orthogonal design was applied to explore the effects of ultrasonic time,solid-to-liquid ratio,extraction time and ethanol precipitation concentration on the extraction rate of crude polysaccharides from C.Capitata,to obtain the optimal extraction process;DPPH and ABTS^+free radical scavenging ability was detected to evaluate its in vitro antioxidant activity.[Results]The optimal extraction process of C.Capitata crude polysaccharide was as follows:solid-to-liquid ratio was 40∶1,the extraction temperature was 50℃,the ultrasonic time was 80 min.Under such conditions,the extraction rate of C.Capitata crude polysaccharide was 10.51%,and the purity was 56.9%;C.Capitata crude polysaccharide has good scavenging ability to DPPH and ABTS^+free radicals,and its IC50values are 0.468 and 0.231 mg/mL,respectively.[Conclusions]The optimized process is simple and feasible,and the C.Capitata polysaccharide has good antioxidant activity in vitro.This experiment provides a basis for the further development and utilization of the C.Capitata polysaccharide.
基金Independent Research Project of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards(Gui Zhong Zhong Zi 201503).
摘要[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chromatography and other modern separation methods and techniques were used to separate and purify the chemical components of the ethyl acetate fraction of the fruit of E.undulata(Wall.)Mez,and based on the physical and chemical properties and spectral data,their structure was identified.[Results]Six compounds were isolated from the fruit of E.undulata(Wall.)Mez,including trimethyl citrate(1),vanillic acid(2),5-hydroxymethylfurfural(3),1,5-dimethyl citrate(4),1,6-dimethyl-5-ethyl citrate(5)and 3,4-dihydroxybenzoic acid(6).[Conclusions]Compounds 1-6 are all isolated from E.undulata(Wall.)Mez for the first time.
摘要Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D. sandidium Wall. et Lindl. could grow at temperature 5 -35 ℃and pH value of 2 - 10, the optimal temperature and pH value were 25℃ and 7 for its growth and sporulation, respectively. Starch was the optimal carbon sources and peptone was the optimal nitrogen source for the growth and sporulation of bacterial colony, re- spectively; PSA and PCA were the optimal media for its growth and sporalation, respectively.
基金Supported by Yunnan Provincial Science and Technology Major Project(202102AA310027).
摘要[Objectives] In order to develop Triplostegia glandulifera Wall.ex DC. into foromula granules, a high performance liquid chromatography (HPLC) determination method and a TLC identification method for loganic acid in decoction pieces, standard decoction and formula granules of T. glandulifera were established, and the quantity value transfer relationship of T. glandulifera pieces-standard decoction-formula granules was investigated.[Methods] An Agilent 1260 II high performance liquid chromatograph and a Waters Symmetry C18 column (4.6 mm×250 mm, 5 μm) were used to perform gradient elution with acetonitrile-0.1%phosphoric acid solution as the mobile phase at a column temperature of 30 ℃ and a flow rate of 1 mL/min, and the detection wavelength was 240 nm. The TLC identification method of T. glandulifera was established using ethyl acetate-methanol-water (10 : 2 : 1) as the developer, and examination was carried out under a UV lamp (254 nm). The quantity value transfer law was analyzed by using the extract yield, the content of loganic acid and TLC chromatograms as the main evaluation indexes.[Results] The method for the determination and identification of loganic acid is stable, reproducible and reliable. The average yield, average loganic acid content and average loganic acid content transfer rate of 3 batches of T. glandulifera formula granules were, respectively, 18.7%, 41.1 mg/g and 43.1%, each of which was within corresponding range of mean±3SD of the 15 batches of standard decoction.[Conclusions] The content determination and TLC identification methods of loganic acid can be used to evaluate the quality of T. glandulifera formula granules. This study provides data basis for further research on T. glandulifera formula granules, and promotes the modernization of medicines for ethnic minorities.
基金Supported by the National Natural Science Foundation of China(Grant No.52271319)the Jiangsu Funding Program for Excellent Postdoctoral Talent,and the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(Grant No.GZC20240618)the Natural Science Foundation of Jiangsu Province of China(BK20231525).
摘要In this study,the dynamic characteristics of microscale floating bubbles near the vertical wall are studied.This occurrence is common in industrial and natural phenomena.Although many studies have been conducted on microscale bubbles,few studies investigate floating bubbles with very small Reynolds number(Re)near the wall,which is the main research goal of this study.Therefore,this study establishes a model for the ascent of small-scale bubbles near a vertical wall using the interFoam solver in OpenFOAM.This study investigates the influences of diverse viscosity parameters,varying distances from the wall,and different gas flow rates on the terminal velocity,deformation,and motion trajectory of bubbles.The results reveal that as liquid viscosity increases,the Re of bubbles gradually decreases and reaches a minimum of 0.012,which is similar to the Re of micrometer-sized bubbles in water.The characteristics of the wall-induced force in the longitudinal direction are closely related to the changes in liquid viscosity.Under low-viscosity conditions,the induced lift is the principal form of action,whereas under high-viscosity conditions,it is primarily manifested as induced drag.
摘要During the construction of underground caverns,the rock masses of intermediate wall between closelyspaced caverns are easy to be destroyed due to excessive blast-induced damage.Limited to the current measurement technology,we cannot achieve rapid assessment of the rock damage,making it difficult to realize real-time adjustments to the blast design.Given that the blast vibration is relatively easy to acquire,the study establishes a correlation between the peak particle velocity(PPV)and the damage depth within the intermediate wall.A field measurement of the blast vibration was conducted in a scenario of excavating closely-spaced caverns.A dynamic finite element model was thereafter established and loaded via the equivalent elastic boundary(EEB)method.The model was verified based on the measurement data of blast vibration,together with an appropriate load amplification coefficient.Then,a series of small dimensional models with single-borehole were created to obtain the rock damage extent under various charge quantity in the near-blast area,while a large dimensional EEB model was applied to capture the PPV distribution in the far-field of blasting under the corresponding charge quantities.Finally,the blast-induced damage depth of the intermediate wall and the PPV at a certain blast center distance were correlated by the charge quantity.The relationships between PPV and damage depth at different blast center distance were fitted.The results indicate that deploying vibration monitoring at about 40 m or 50 m from the blasting face can estimate in advance the damage depth of intermediate wall,which can help provide some guidance to the blast of closely-spaced caverns.
基金supported by the project of the National Natural Science Foundation of China(Grant Nos.22568052 and 22466038)Yunnan Provincial Science and Technology Project at Southwest United Graduate School(Grant No.202402AO370002)+2 种基金the Project of Yunnan Provincial Department of Education Science Research Fund(Grant No.2026Y0053)the Scientific Research and Innovation Project of Postgraduate Students in the Academic Degree of Yunnan University(Grant No.KC-252512353)Yunnan University Undergraduate Innovation Training Program(Provincial-level Project)(Grant No.S202510673275)。
摘要Recovering palladium(Pd)from low-concentration metallurgical wastewater still poses significant challenges.In this study,triaminoguanidine hydrochloride was used as the key functional site,and three guanidine-functionalized covalent organic frameworks(GCOFs)were successfully constructed by adjusting the substituents(-H,-OH,and-OCH3)on terephthalaldehyde molecules,and their extraction performance towards palladium was explored.First,multiple characterization techniques,including scanning electron microscopy,zeta potential analysis,and contact angle measurement,were employed to systematically investigate the regulatory rules of substituents on the physicochemical properties of GCOFs,such as their micromorphology,surface potential,and hydrophilicity.Second,static adsorption experiments were conducted to systematically study the adsorption behavior of GCOFs with different substituents toward Pd(Ⅱ),and the maximum sorption capacity of COF-H is up to 180 mg g-1.Furthermore,this study successfully fabricated GCOFs into aerogels by means of freeze-drying technology and conducted dynamic adsorption experiments with actual metallurgical wastewater.Specifically,70.0 mg of COF-H/aerogel is capable of continuously treating 12.5 L of metallurgical wastewater.In conclusion,by regulating the types of substituents,this study clarified the influence rules of substituent effects on the Pd(Ⅱ)adsorption performance of GCOFs in metallurgical wastewater.The developed GCOFs/aerogels hold broad application potential in the fields of precious metal resource recovery and environmental protection.
基金supported by the Key Research and Development Program of Xinjiang Uygur Autonomous Region(2024B02004)China Agriculture Research System of MOF and MARA(CARS-15-14)+1 种基金Fundamental Research Funds for the Central Universities(KYLH2023004,XUEKEN2023028)Collaborative Innovation Center for Modern Crop Production co-sponsored by Province and Ministry(CIC-MCP)。
摘要To determine how high temperature(HT)impairs cotton fiber elongation,greenhouse experiments compared two temperature regimes(CT,28℃HT,38℃)for 12 d.The findings indicated that compared with CT,the fiber elongation rate initially increased during HT(0-8 d),but subsequently decreased,resulting in a significant decrease in cotton fiber length at harvest.At 3 and 6 d under HT,cell turgor pressure increased;additionally,the auxin and ethylene content in fiber significantly increased,promoting cell wall loosening and increasing elongation rate through regulating xyloglucan endoglycosyltransferases/hydrolases and expansin.At 12 d under HT,cellulose and hemicellulose decomposition were inhibited in fiber,which hindered cell wall loosening and restricted fiber elongation.Meanwhile,the lipid and callose content in fiber was increased,and the enhanced abscisic acid and H2O2content promoted lignin synthesis by up-regulating the expression of WLIM1a gene.Both changes accelerated the initiation of secondary wall synthesis.Consequently,the transition stage that coincides with fiber elongation and secondary wall thickening was reduced by 0.3-0.5 d,leading to a decrease in fiber length.In summary,fiber length was reduced under HT,accompanied by restricted cell wall loosening and accelerated secondary wall synthesis.
基金Youth Innovation Team of Shandong Higher Education Institutions,Grant/Award Number:2022KJ214Shandong Postdoctoral Science Foundation,Grant/Award Number:SDCXZG‐202303031+2 种基金China Postdoctoral Science Foundation,Grant/Award Number:2023M732109National Natural Science Foundation of China,Grant/Award Number:52209141Natural Science Foundation of Shandong Province,China,Grant/Award Number:ZR2021QE069。
摘要The deformation and failure of coal walls in front of a working face cause significant difficulties during mining operations.This study reveals the nonuniform distribution of bearing pressure in front of coal walls based on in situ monitoring data and numerical simulation.Therefore,an eccentric compression mechanical model was established to study the deformation and failure characteristics of a coal wall.The slenderness ratio of the compression bar is introduced to define coal walls.The results showed that instability failure occurs when λ>λc and material failure occurs when λ≤λc.The instability failure-type coal wall spalling was related to the mining height,eccentricity of roof pressure,the horizontal force,and the reaction moment of the floor.The material failure-type coal wall spalling was related to the cohesion,the internal friction angle of the coal,the upper pressure,and the horizontal force of coal walls.Unstable and destructive coal wall peeling usually occurs at a height of 0.5–0.6 times the mining height,while material damage to coal wall peeling is determined to occur within the range of 0.4-0.6 times the mining depth.The findings contribute to the understanding of the deformation and failure of coal walls.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.2242023K5006)the Jiangsu Civil Defense Office Program(Grant No.7605009117).
摘要Excavation-induced retaining wall deflection(RWD)significantly influences the safety of surrounding built environment.To predict the three-dimensional RWD in heterogeneous strata,a new partial differential equation(PDE)is derived in this study,and two prediction models are proposed,i.e.the physics-informed neural network(PINN)model and the data-driven PINN model.As a physical constraint,the new PDE is crucial to the loss functions of these models.Then,the validity of the models is verified and analysed using a subway deep-foundation pit.The results show that the training times of both models are controlled within 900 s,which is a significant reduction compared to that of the conventional numerical model.In addition,the prediction accuracy of the data-driven PINN model is higher than that of the numerical model,while that of the PINN model is slightly lower than that of the numerical simulation.However,in contrast to the data-driven PINN model,the PINN model can identify irregular soil interfaces in heterogeneous strata to learn the deflection continuity conditions at irregular interfaces and realize RWD prediction in non-uniform distributed strata.In practical applications in foundation pit engineering,the selection of the PINN and data-driven PINN models can be conducted according to the in situ distribution conditions of the strata to enable the early prediction of potential RWD,thereby providing a reliable basis for the further optimisation of retaining structures design.
基金National Natural Science Foundation of China(52203378,52301143)。
摘要Spherical and capsule-shaped surface tension tanks are widely used in satellite,spacecraft,and other fields due to their advantages of lightweight structure,high efficiency,and high reliability.With the advancement of space exploration,the demands for thinner walls,more complex structures,and uniform overall performance in the hemispherical shells of these tanks present significant challenges for hemispherical shell forming technique.A hemispherical shell with uniform wall thickness was prepared using the rapid direct-and-reverse superplastic forming method.Results reveal that the properties and microstructure of each section of the formed hemisphere shell are consistent with those of the initial plate,and the overall shell thickness is highly uniform.
基金financially supported by the National Key Research and Development Program of China(Grant No.2022YFC2806604)the National Natural Science Foundation of China(Grant No.52101359)+1 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX24_4069)the Jiangsu Marine Technology Innovation Center“Key Technology Research and Development of Deep-sea Polymetallic Nodule Seafloor Mining Equipment”(Grant No.MTIC-2023-IRD-0001).
摘要The negative pressure near-wall particle collection method employs suction flow to circulate the medium along the inner wall of the collection port,creating flow separation that affects flow characteristics and particle forces.This investigation utilizes a CFD simulation method,validated through Zhao’s experiments,and implements a“circular pipe suction model”to examine how collection port parameters-specifically wall thickness and shape-influence the flow field and particle collection efficiency across different Reynolds numbers.The findings demonstrate that wall thickness and port shape substantially affect flow separation,as evidenced by recirculation zones that compress the flow and modify the particle force coefficient.Typically,greater wall thickness results in decreased particle force coefficients,with variations up to 15%.Moreover,collection ports with inward-pointing sharp angles demonstrate the highest particle force coefficients,while those with outward-pointing angles show the lowest,exhibiting variations up to 23%.These results indicate that optimizing collection port design through wall thickness and shape modifications can improve particle collection efficiency,enhancing practical applications.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFA0715600)the National Natural Science Foundation of China(Grant Nos.62425408,12574085,and 62522413)the Natural Science Foundation of Jilin Province(Grant No.SKL202602020JC).
摘要In the past decade,the discovery of robust ferroelectricity in scandium-doped aluminum nitride(Al1−xScxN)[1]has ignited a new wave of research in the semiconductor community.Unlike traditional perovskite ferroelectrics(such as PbZrTiO3 or PZT)[2],wurtzite-structured materials are fully compatible with modern CMOS fabrication processes[3].