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Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway 认领 引用 被引量：4
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作者 Jiawei He Anhui Yang +3 位作者 Xuyu Zhao Yang Liu Shuyan Liu Di Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2021年第4期460-470,共11页
The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated i... The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated in this study that the anti-colon cancer effect of polysaccharides purifi ed from GI(GIPS)in ApcMinC/Gpt mice(an in situ colon cancer mouse model).Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without infl uencing the animals’body weight and organ functions.According to the proteomics performing by antibody array,among 308 detected cytokines,GIPS significantly regulated 89 of them.Compared with vehicle-treated mice,GIPS effectively reduced the levels of interleukin(IL)-1β,IL-4,IL-6,IL-17,IL-22,tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-2,and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues,which suggested its anti-inflammation of GIPS.GIPS suppressed nuclear aggregation of β-catenin,affected the expression of WNT1 and related proteins,thereby regulated the activation of the Wnt signaling.Altogether,GIPS can inhibit the growth of colon cancer,at least partially,via inhibiting the Wnt/β-catenin signaling pathway. 展开更多
关键词 Gloeostereum incarnatum Water-soluble polysaccharides Colon cancer Wnt/β-catenin
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Structural Analysis of Water-soluble Polysaccharide PIP_1 Extracted from the Cultured Mycelium of Phellinus igniarius 认领 引用 被引量：9
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作者 WU Ming-jiang JIANG De-zhi +1 位作者 LIU Tie-mei ZHANG Li-ping 《Chemical Research in Chinese Universities》 SCIE EI CAS 2006年第6期708-711,共4页
Water-soluble crude polyseccharide（PIP） was extracted from cultured mycelium of the fungus Phellinus igniarius. After ethanol precipitation and sepharose CL-6B gel filtration, the fraction of PIP1 was obtained, whic... Water-soluble crude polyseccharide（PIP） was extracted from cultured mycelium of the fungus Phellinus igniarius. After ethanol precipitation and sepharose CL-6B gel filtration, the fraction of PIP1 was obtained, which was shown to be a homogeneous polysaccharide by means of high-performance liquid chromatography. The structure of PIPt was determined by using several methods. C.,C analysis indicates that PIP1 is composed of the monosaccharides of glucose, galactose, and mannose. Their malar ratio is 3. 70： 4. 06： 1.00. The molar weight was estimated to be 17 kd via HPLC. IR, GC, partial hydrolysis with acid, pefiedate oxidation, Smith degradation, methylation, and GC-MS analysis were used for the structural analyses of PIP1. The results show that PIP1 has a small quantity of branch structure, The main glycosidic linkage of PIP1 has a β-configurafion. The main chain is made up of a large mass of glucose （ 1→3 ） and few mannose （ 1→4 ） ; the side chain is composed of glucose （ 1 →3 ） and galactose （ 1→6 ） ; the nonreduced end is composed of galactose and glucose. The side chains are branched at 6-0 of glucose（ 1→3,6） and mannose（1→4,6）. On an average, there are three branches among 20 residues. It is presumable that the existence of 1,3-linked Glc in the main and side chains is the main reason for its higher antitumor activity. 展开更多
关键词 Phellinus igniarus Cultured mycelium Polysaccharide Structural analysis
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Extraction of Water-soluble Polysaccharide from Pumpkin and Its Antioxidant Activity 认领 引用 被引量：9
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作者 孙婕 尹国友 +2 位作者 李文建 吕灵娟 吉晓辉 《Agricultural Science & Technology》 CAS 2010年第11期54-55,106,共2页
In this study,an orthogonal experiment was performed to explore the optimal extraction technique of water-soluble polysaccharides from pumpkin.Moreover,the polysaccharides＇ capabilities to scavenge ·OH and DPPH&... In this study,an orthogonal experiment was performed to explore the optimal extraction technique of water-soluble polysaccharides from pumpkin.Moreover,the polysaccharides＇ capabilities to scavenge ·OH and DPPH· and their gross reducing power was measured with Vc and BHT as references.In the orthogonal experiment,various factors including temperature,extraction time,solid-liquid ratio,were optimized.The results showed that the polysaccharides extracted from pumpkin are endowed with strong in vitro antioxidant properties.Our study provided references for the extraction of pumpkin polysaccharides and for their use as antioxidants. 展开更多
关键词 Pumpkin polysaccharides Extraction Antioxidation
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Structural characterization and immunostimulatory activity of a water-soluble polysaccharide from abalone(Haliotis discus hannai Ino)muscle 认领 引用 被引量：4
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作者 Linfan Shi Gengxin Hao +2 位作者 Jun Chen Junling Wang Wuyin Weng 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第2期495-502,共8页
A water-soluble polysaccharide from abalone muscle(AMPP)was isolated.The contents of carbohydrate,protein,uronic acid,and sulfate in AMPP were 83.5%,0.5%,2.7%,and 2.6%,respectively.High-performance liquid chromatograp... A water-soluble polysaccharide from abalone muscle(AMPP)was isolated.The contents of carbohydrate,protein,uronic acid,and sulfate in AMPP were 83.5%,0.5%,2.7%,and 2.6%,respectively.High-performance liquid chromatography analysis indicated that AMPP was homogeneous and had an average molecular weight of approximately 3.2 kDa.The main monosaccharides of AMPP were glucose(Glc)and mannose with a molar ratio of 99.7:0.3.The structural characteristics of AMPP were elucidated through methylation analysis,Fourier transform infrared spectroscopy,and nuclear magnetic resonance spectroscopy.The linkages of AMPP consisted of terminal,1,4-linked,1,6-linked,and 1,4,6-linked Glcp with a molar ratio of 3.1:7.2:1.0:2.5.In one repeat unit of the proposed AMPP structure,the backbone chain was composed of eight 1→4 glycosidic bonds and one 1→6 glycosidic bond,with three branch chains linked by 1→6 glycosidic bond.In addition,AMPP was found to possess potent immunostimulatory activity via rising phagocytosis of RAW264.7 cells and promoting secretion of TNF-α. 展开更多
关键词 Polysaccharide Abalone muscle Structural characterization Immunostimulatory activity Nuclear magnetic resonance spectra
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Antioxidant activity of water-soluble polysaccharide extracted from Eucalyptus cultivated in Lebanon 认领 引用 被引量：1
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作者 Marianne Haddad Salam Zein +3 位作者 Hawraa Shahrour Kamar Hamadeh Nadine Karaki Hussein Kanaan 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2017年第2期157-160,共4页
Objective: To extract and identify the chemical composition of the polysaccharide isolated from the Eucalyptus cultivated in Lebanon and to evaluate its antioxidant activity.Materials: The water-soluble polysaccharide... Objective: To extract and identify the chemical composition of the polysaccharide isolated from the Eucalyptus cultivated in Lebanon and to evaluate its antioxidant activity.Materials: The water-soluble polysaccharide was isolated from Eucalyptus leaves, and its structure was identified by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, and carbon-13 nuclear magnetic resonance. The antioxidant activity of the active ingredient was screened for its radical scavenging ability using 2,2-diphenyl-1-picryl-hydrazyl radical(DPPH) test.Results: The results of the DPPH test have shown that fucoidan, the polysaccharide isolated from Eucalyptus, exhibited almost the same antioxidant activity against DPPH$as the ascorbic acid did at 100 mg/mL.Conclusions: This natural molecule extracted from a medicinal plant has a promising antioxidant activity and could be used in pharmaceutical and medical applications. 展开更多
关键词 Eucalyptus Polysaccharide Fucoidan Antioxidant
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Isolation, purification and structural characterization of a water-soluble polysaccharide HM41 from Halenia elliptica D.Don 认领 引用
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作者 Chun-Lan Liu Yang Li +1 位作者 Gui-Yun Xu Ya-Shuang Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第6期979-983,共5页
A water-soluble polysaccharide, HM（41）, was obtained from Halenia elliptica D. Don by acidic ethanol fractionation and gel filtration. Its homogeneity was confirmed by chromatography using multiple systems. HM（41）... A water-soluble polysaccharide, HM（41）, was obtained from Halenia elliptica D. Don by acidic ethanol fractionation and gel filtration. Its homogeneity was confirmed by chromatography using multiple systems. HM（41） was composed of rhamnose（Rha）, arabinose（Ara）, xylose（Xyl）, mannose（Man）,galactose（Gal）, glucose（Glc） with a molar ratio of 1.0：5.5：1.8：3.0：9.4：21. The average molecular weight of HM（41） was approximately 1.17 ＊ 10~4. Periodate oxidation, Smith degradation, methylation and GC, IR,NMR, XRD, GC–MS analysis were used for the structural analysis of HM（41）. Its main chain was composed mainly of β-（1→4）Gal, β-（1→4）Glc and β-（1→6）Glc. β-（1 →4）Gal were substituted at 6-O and on average there were 14 branches among 23 main chain residues;（1→ 4）Glc had no branch;（1→6）Glc were substituted at 3-O and on average there were 9 branches among 14 main chain residues. The side chain was composed of（1→3,6）-Rha,（1→4）/（1→5）-Ara,（1 →4）/（1→5）-Xyl,（1→4,6）-Man and（1→2）-Glc. The terminal residue was composed of Ara, Xyl, Man, Gal, and Glc. Then, we demonstrated that HM and HM（41） had strong scavenging activities in vitro hydroxyl. Overall, HM and HM（41） may have potential applications in the antioxidants for medical and food industry. 展开更多
关键词 Halenia elliptica D.Don Polysaccharide Isolation purification Structural analysis Antioxidant activities
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Inquiry of Water-Soluble Polysaccharide Extraction Conditions from Grapefruit Skin 认领 引用 被引量：9
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作者 Ziping Luo Zilin Liu +3 位作者 Shiyu Tan Qiliang Xu Haiyan Yang Lingli Yang 《Engineering（科研）》 2011年第11期1090-1094,共5页
Water-soluble polysaccharide was isolated from grapefruit with the method of water-dissolving and ethanol-precipitating. By single factor test and orthogonal experimental method, the extraction conditions of the water... Water-soluble polysaccharide was isolated from grapefruit with the method of water-dissolving and ethanol-precipitating. By single factor test and orthogonal experimental method, the extraction conditions of the water-soluble polysaccharide were investigated, which contained liquid-solid ratio, temperature, time and pH. The results showed that pH was the most important factor of polysaccharide extraction, followed by temperature. The optimized extraction technology conditions were obtained. The liquid-solid ratio was 1:40, temperature was 90?C, time was 2.0 h, and pH was 2. The highest extraction rate of crude polysaccharide was 8.30%. 展开更多
关键词 Grapefruit Water-Soluble Polysaccharide Extracting Condition Single Factor Experiment and Orthogonal Experiment
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Identification of Two Cold Water-Soluble Polysaccharides from the Stems of Ephedra sinica Stapf 认领 引用 被引量：5
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作者 Yonggang Xia Jun Liang +2 位作者 Bingyou Yang Qiuhong Wang Haixue Kuang 《Chinese Medicine》 CAS 2010年第3期63-68,共6页
Two polysaccharides (ESP-A1 and ESP-A2) were isolated from the cold water extract of Ephedra sinica Stapf and purified through ethanol precipitation, deproteinization and by ion exchange and gel-filtration chromatogra... Two polysaccharides (ESP-A1 and ESP-A2) were isolated from the cold water extract of Ephedra sinica Stapf and purified through ethanol precipitation, deproteinization and by ion exchange and gel-filtration chromatography. Their molecular weight was determined using high performance size exclusion chromatog-raphy and evaporative light scattering detector (HPSEC-ELSD) and their monosaccharide composition was analyzed by high performance capillary electrophoresis (HPCE) based on pre-column derivatization with 1-phenyl-3-methyl-5-pyrazolone (PMP). It was shown that ESP-A1 consisted of xylose, arabinose, glucose, mannose and galactose and ESP-A2 consisted of xylose, arabinose, rhamnose and galactose, in a molar ratio (%) of 3.2: 61.1: 11.1: 12.9: 11.6 and 20.6: 67.7: 5.0: 6.7, respectively. The molecular weights (Mw) of ESP-A1 and ESP-A2 were 5.83 × 104 Da and more than 200 × 104 Da, respectively. To the best of our knowledge, two neutral polysaccharides are now being reported for the first time in this study. 展开更多
关键词 Ephedra sinica Stapf Polysaccharides Isolation and Purification Molecular Weight Monosaccharide Composition
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Phellodendron amurense Rupr.Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota 认领 引用 被引量：1
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作者 Mei Mei Huawei Sun +3 位作者 Kai Zhang Feng Zhang Shiqing Sun Yu Zhang 《Natural Products and Bioprospecting》 CSCD 2026年第1期212-229,共18页
In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism o... In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism of Phellodendron amurense Rupr.Polysaccharides(PAP)in ameliorating DN.Results demonstrated that PAP,a neu-tral homogeneous polysaccharide with molecular weight of 1.98 × 105 Da composed of Rha,GalA,Gal,and D-Xyl,exerted renal protective effects through multiple pathways.It enhanced renal antioxidant capacity and alleviated oxidative damage in DN by upregulating PI3K/AKT pathway-related protein expression.Simultaneously,PAP acti-vated theTGF-β/Smad pathway via Nrf2 to mitigate renal fibrosis symptoms in DN,while inhibiting cellular apoptosis.Furthermore,PAP suppressed renal inflammation through gut microbiota reduction,thereby protecting against renal injury in DN rats.This study reveals that PAP alleviates DN symptoms by modulating gut microbiota,enhancing anti-oxidant and anti-fibrotic capacities,and inhibiting apoptotic pathways,comprehensively elucidating its multifaceted therapeutic mechanisms against DN. 展开更多
关键词 Phellodendron amurense Rupr.Polysaccharides Diabetic nephropathy Gut microbiota
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Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging 认领 引用
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作者 Ping-Ting Gong Jiao-Jiao Guo +7 位作者 Chang Gao Wei-Tao Yang Chun-Sheng Xiao Yi Xu Yue Yao Irshad Hussain Wen Fan Wei Yan 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第2期407-415,I0011,共9页
Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity an... Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T2-weighted MRI contrast agent. 展开更多
关键词 Iron oxide nanoparticles Water-soluble polymer ligand Magnetic resonance imaging
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Antiradiation effects of ginseng polysaccharide and its application prospects in future food 认领 引用
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作者 Ming Jiang Dan Xiao +4 位作者 Xin Li Yukun Ma Yueming Lin Yu Jiao Hui Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2039-2051,共13页
Panax ginseng,a foundational herb in traditional East Asian medicine,has been extensively studied for its therapeutic and nutritional properties.Among its bioactive constituents,ginseng polysaccharides(GPs)stand out f... Panax ginseng,a foundational herb in traditional East Asian medicine,has been extensively studied for its therapeutic and nutritional properties.Among its bioactive constituents,ginseng polysaccharides(GPs)stand out for their potent antioxidant,anti-inflammatory,and immunomodulatory effects.These polysaccharides,primarily composed of monosaccharides such as glucose,galactose(Gal),and arabinose(Ara),demonstrate promising potential in alleviating oxidative stress and immune suppression.With increasing exposure to ionizing radiation from medical and industrial sources,the demand for effective radioprotective agents has grown.Ionizing radiation induces DNA damage and excessive reactive oxygen species(ROS)production,resulting in oxidative stress and immune dysfunction.Research suggests that GPs mitigate radiation-induced cellular damage by enhancing antioxidant enzyme activity,suppressing inflammatory cytokines,and regulating immune responses.Despite these encouraging findings,further investigations are needed to elucidate their mechanisms of action and optimize their clinical applications.This review provides a comprehensive analysis of the composition,biological activities,and radioprotective mechanisms of GPs,highlighting their potential as functional agents for safeguarding human health against radiation-induced damage. 展开更多
关键词 Antiradiation Ginseng polysaccharide Future food
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Characterization of a pectic heteropolysaccharide isolated from persimmon peel and its anti-inflammatory activity 认领 引用
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作者 Yanlong Cui Siyue Cao +3 位作者 Qinghuan Yu Xin Wang Mohamedelfatieh Ismael Xin Lü 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2294-2309,共16页
A main component,pectic polysaccharide(PPP-4),was isolated from persimmon peel.PPP-4 had the molecular weight of 56.48 kDa and primarily consisted of galacturonic acid,arabinose,galactose,rhamnose with the molar ratio... A main component,pectic polysaccharide(PPP-4),was isolated from persimmon peel.PPP-4 had the molecular weight of 56.48 kDa and primarily consisted of galacturonic acid,arabinose,galactose,rhamnose with the molar ratios of 60.80:32.12:3.67:2.20.The backbone of PPP-4 was formed by→4)-α-D-GalpA-(1→and→2,4)-α-L-Rhap-(1→with branches of 3)-α-L-Araf-(1→,and→3)-β-L-Galp-(1→,→5)-α-L-Araf-(1→,→3,5)-α-L-Araf-(1→residues and terminals of 4-β/α-D-GalpA and T-α-L-Araf residues.Besides,PPP-4consumption could relieve colonic pathological damage,inhibit the expression of proinlammatory cytokines(IL-1β,IL-6,and TNF-α)in serum,increase the fecal short chain fatty acids(SCFAs)and improve antioxidant capacity in dextran sodium sulfate(DSS)-induced colitis mice.Simultaneously,PPP-4 was revealed to regulate flora disorder,reduce the relative abundance of harmful microbe(Dubosiella,Odoribacter,Parasutterella,and Turicibacter,etc.)and increase the relative abundance of beneficial microbe(such as Akkermansia and Lactobacillus)in colitis mice.Overall,these data would furnish new theoretical basis for the structural information of PPP-4 and highlight its potentiality to be considered as a natural anti-inflammation reagent. 展开更多
关键词 Persimmon peel polysaccharide Inflammation Gut microbiota
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Recent Advances in Natural Polysaccharide-Based Materials for Wound Healing:Chitosan,Konjac Glucomannan and Cellulose 认领 引用
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作者 Jin Shang Weimin Zhang +4 位作者 Landuo Zhang Xiangwen Li Qi Wang Peng Zhao Liangliang Duan 《Journal of Renewable Materials》 EI CAS 2026年第4期49-98,共50页
Wound healing is a complex and dynamic process essential for restoring the integrity of damaged skin.It requires wound dressings that actively regulate the wound microenvironment by preventing infection,maintaining mo... Wound healing is a complex and dynamic process essential for restoring the integrity of damaged skin.It requires wound dressings that actively regulate the wound microenvironment by preventing infection,maintaining moisture balance,allowing gas exchange,and managing exudate.Natural polysaccharides,such as konjac glucomannan(KGM),chitosan,and cellulose,are well suited to this role because of their biocompatibility,biodegradability,and intrinsic bioactivity.Extensive research has focused on developing polysaccharide-based wound dressings with enhanced functionality to promote healing.This review examines recent scientific research published mostly in the past five years on the development and application of chitosan,KGM and cellulose-based macromolecules for wound dressing fabrication,including hydrogels,sponges,fibers,and other forms.It explores how their structure-propertyfunction relationships connect primary composition and inter-component interactions(e.g.,hydrogen bonding,ionic complexation,covalent crosslinking)to key performance metrics(antibacterial efficacy,hemostatic activity,moisture management such as swelling and water vapor transmission rate,and mechanical robustness).The advantages and disadvantages of various methods for preparing materials of the same type using the same polysaccharide are also discussed with quantitative comparisons across studies to provide clear insights into the healing effects of different wound dressings.For relatively mature cellulose-based wound dressings,we integrate their therapeutic efficacy,functional mechanisms,clinical evidence and marketed products with typical indications.Additionally,we summarize the advantages and limitations of these polysaccharides inwound healing,while identifying future trends and challenges that should guide the rational design of polysaccharide-based wound dressings. 展开更多
关键词 Wound healing polysaccharide chitosan konjac glucomannan wound dressing cellulose
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A review of food-derived polysaccharides in intervening in disorders of glucose and lipid metabolism:an inter-organ crosstalk between gut,liver,adipose tissue,and nervous system 认领 引用
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作者 Weijun Cui Xiangyang Zhu +5 位作者 Chunli Hu Xueping Li Xinling Song Shiwei Yu Dapeng Li Chen Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期508-519,共12页
The diseases caused by disorders in glucose and lipid metabolism have become one of the prevalent health issues,posing a serious threat to human health.Previous studies have shown that food-derived polysaccharides hav... The diseases caused by disorders in glucose and lipid metabolism have become one of the prevalent health issues,posing a serious threat to human health.Previous studies have shown that food-derived polysaccharides have a certain intervention effect on disorders in glucose and lipid metabolism.This article reviewed the structure-function relationship of food-derived polysaccharides and elucidated their role in regulating glucose and lipid metabolism.Some new evidence suggests that secondary metabolites such as short-chain fatty acids,secondary bile acids,and lipopolysaccharide act as signaling molecules,activating pathways related to glucose and lipid metabolism,alleviating oxidative stress,inhibiting inflammation in the body,and regulating the homeostasis of glucose and lipid metabolism.These results indicated that food-derived polysaccharides have a positive impact on the regulation of glucose and lipid metabolism by improving the gut microbiota environment.On the other hand,gut microbiota disturbance can affect the host’s health through the gut-liver,gut-brain and gut-adipose tissue axes.Therefore,it is speculated that food-derived polysaccharides may intervene in glucose and lipid metabolism through the inter-organ crosstalk between gut,liver,adipose tissue,and nervous system.This essay provides a theoretical basis for the development and utilization of food-derived polysaccharides as prebiotics in intervening disorders in glucose and lipid metabolism. 展开更多
关键词 Food-derived polysaccharides Glucose and lipid metabolism Anti-inflammatory Intestinal flora
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Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2,AMPK pathways and reshaping gut microbiota 认领 引用
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作者 Huajie Zhao Liang Liu +6 位作者 Ningning Liu Baoguo Deng Min Li Duan Li Le Jia Ge Wang Fan Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1323-1342,共20页
One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column... One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD. 展开更多
关键词 Laetiporus sulphureus polysaccharides Alcoholic liver disease Lipid metabolism Oxidative stress Gut microbiota
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Polygonatum sibiricum Red.and its polysaccharides in cognitive improvement:Pharmacological mechanisms and therapeutic potential 认领 引用
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作者 Cong Lu Xiangfei Zhang +3 位作者 Lifang Chen Jing Sun Bei Fan Fengzhong Wang 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2026年第2期139-149,共11页
Cognitive impairment is a growing public health concern associated with aging,neurodegenerative diseases,and chronic stress.Polygonatum sibiricum Red.(P.sibiricum,Huang Jing),a traditional Chinese medicinal herb,is us... Cognitive impairment is a growing public health concern associated with aging,neurodegenerative diseases,and chronic stress.Polygonatum sibiricum Red.(P.sibiricum,Huang Jing),a traditional Chinese medicinal herb,is used to reinforce qi,strengthen the spleen,and nourish yin.Recent studies have suggested that P.sibiricum polysaccharides(PSP),its major bioactive constituents,exert neuroprotective effects through antioxidant and anti-inflammatory actions,modulation of the gut-brain axis,and improvement of synaptic plasticity.This review summarizes recent advances in the pharmacological activities of P.sibiricum and PSP related to cognitive improvement,highlights findings from behavioral,cellular,and molecular studies,and examines the clinical evidence supporting their therapeutic potential.Understanding the mechanism of action of P.sibiricum offers new insights into its potential development as a functional food or complementary therapeutic agent for cognitive decline. 展开更多
关键词 Polygonati rhizoma Polysaccharides Medicine and food homology Cognitive impairment Neuroprotection
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Structural analysis of a neutral polysaccharide ATP-1 from the red seaweed Asparagopsis taxiformis and its immunomodulatory effects on RAW264.7 macrophages 认领 引用
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作者 Kun Yang Baojun Xu +3 位作者 Wei Hu Yifan Tang Amy Hui-Mei Lin Saiyi Zhong 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1851-1864,共14页
As a seaweed supplement,the powdered,entire herb of Asparagopsis taxiformis can effectively promote immune response in animals.However,the active factors responsible for this effect are currently unknown.A novel polys... As a seaweed supplement,the powdered,entire herb of Asparagopsis taxiformis can effectively promote immune response in animals.However,the active factors responsible for this effect are currently unknown.A novel polysaccharide,ATP-1,was isolated and purified from the red alga A.taxiformis,and its structural and immunomodulatory properties were determined.ATP-1 is a neutral polysaccharide with a molecular weight of 307.978 k Da and is primarily composed of galactose(94.07%),glucose(1.27%),and xylose(4.66%).Scanning electron microscopy and atomic force microscopy revealed that ATP1 had an amorphous structure and was composed of molecular chain entanglement and intramolecular hydrogen bonding interactions.The microstructure of ATP-1 exhibited asymmetric sheet–like cracks and pores.Results from immunomodulatory activity showed that ATP-1 promoted inducible nitric oxide(NO)synthase and cyclooxygenase(COX)-2 protein expression in RAW264.7 macrophages,improved macrophage phagocytic ability,and stimulated cytokine production(NO,tumor necrosis factor(TNF)-α,and interleukin(IL)-6).Quantitative proteome analysis identified 178 differentially expressed proteins(70 upregulated and 108 downregulated)that were involved in various molecular pathways,among which,TNF was one of the 20 most common and significant signaling pathways in inflammation and immunoregulation.Western blotting indicated that ATP-1 significantly upregulated the expression of IKKα,IKKβ,COX-2,and TNF-αproteins in the TNF pathway.In contrast,ATP-1 downregulated the expression of IκBα,Fas,and AIP1.Results from molecular docking suggested that hydrogen bonding predominantly contributed to the affinity between TNF-αand galactose,glucose,and xylose.These findings indicated that ATP-1 may play an immunomodulatory role by activating the TNF signaling pathway.ATP-1 enhanced macrophage phagocytic capacity and stimulated the production of cytokines NO,TNF-α,and IL-6,thereby exerting immunoregulatory effects.Our findings highlight the potential of ATP-1 as a natural immune modulator with applications as a functional food. 展开更多
关键词 Red seaweed Asparagopsis taxiformis Structural characterization Immune regulation TNF signaling pathway Polysaccharide
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Anti-inflammatory mechanisms of Hedysarum polybotrys polysaccharide in endotoxin-induced uveitis:insights into candidate genes and pathways 认领 引用
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作者 Shuo Yu Jin-Yi Yu +3 位作者 Xin-Li Liu Jing Wang Shi-Lan Feng Hong Lu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第2期230-238,共9页
AIM:To identify key genes and inflammatory signaling pathways involved in the anti-inflammatory effects of Hedysarum polybotrys polysaccharide(HPS)in a rat model of endotoxin-induced uveitis(EIU).METHODS:EIU was induc... AIM:To identify key genes and inflammatory signaling pathways involved in the anti-inflammatory effects of Hedysarum polybotrys polysaccharide(HPS)in a rat model of endotoxin-induced uveitis(EIU).METHODS:EIU was induced in Wistar rats through subcutaneous injection of lipopolysaccharide(LPS,200μg)and the rats were then randomly assigned to EIU group(n=5)and the HPS intervention group(n=5).HPS(400 mg/kg,intraperitoneally)or its carrier was administered 24h and 1h prior to EIU induction.Eyes were examined and enucleated 24h post-induction,and total RNA was extracted from the iris-ciliary body.Gene expression microarrays were used to identify differentially expressed genes(DEGs),followed by bioinformatics analyses,including gene ontology(GO)and pathway analysis.Key findings were not experimentally validated at the mRNA or protein level.RESULTS:A total of 322 DEGs were identified,comprising 254 mRNA and 68 lncRNA genes.GO analysis revealed significant functional categories,including response to LPS.Pathway analysis identified key signaling pathways involved in uveitis,such as cytokine-cytokine receptor interactions.Notably,16 mRNA and 7 lncRNA DEGs emerged as central nodes in the gene correlation network.CONCLUSION:HPS exerts its anti-inflammatory effects through coordinated signaling pathways,offering insights into potential therapeutic targets for managing uveitis. 展开更多
关键词 differentially expressed genes Hedysarum polybotrys polysaccharide endotoxin-induced uveitis lncRNA gene expression microarray
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Nephroprotective effects and antioxidant mechanisms of a novel polysaccharide from Poria cocos sclerotia in chemotherapy-induced kidney injury 认领 引用
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作者 Daolun Yu Kai Ge +3 位作者 Naidong Chen Zhiqiang He Yinuo Gong Zongmeng Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2453-2473,共21页
kidney injury is one of the common side effects in cancer patients receiving chemotherapy.Enhancement of renal antioxidant and anti-inflammation function are important strategies to combat chemotherapy-induced kidney ... kidney injury is one of the common side effects in cancer patients receiving chemotherapy.Enhancement of renal antioxidant and anti-inflammation function are important strategies to combat chemotherapy-induced kidney injury.In this study,we successfully isolated a novel water-soluble polysaccharide from Poria cocos sclerotia)Poria cocos polysaccharides(PCP),molecular weight:55.245 kDa),which features anα-1,4-D-Glcp backbone with branches linked at the O-6 positions.In vitro,PCP significantly relieved oxidative damage and apoptosis caused by the chemotherapeutic agent cisplatin in renal tubular epithelial cells(RTECs).In vivo,pretreatment with PCP attenuated cisplatin-induced kidney injury by mitigating oxidative stress,apoptosis,and inflammation.Furthermore,post-treatment with PCP facilitated the recovery of renal function following kidney injury.In chronic kidney injury model,PCP exhibited a persistent nephroprotective effect in inhibiting the progression of chronic kidney disease and fibrosis.Mechanistically,PCP protected RTECs from cisplatin by activating the nuclear transcription factor E2-related factor 2(Nrf2)signaling pathway.Importantly,PKCζwas identified as the upstream kinase responsible for initiating the phosphorylation activation of Nrf2.Taken together,PCP confers protection against cisplatin-induced kidney injury by activating the PKCζ-Nrf2 signaling pathway,suggesting that PCP may be a promising clinical candidate for the treatment of chemotherapyinduced kidney injury. 展开更多
关键词 Poria cocos polysaccharides Antioxidant Cisplatin Kidney injury Nuclear transcription factor E2-related factor 2
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Agrocybe cylindracea polysaccharides repair the intestinal mucosal barrier in DSS-induced colitis by modulating the gut microbiota-macrophage axis 认领 引用
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作者 Zaoxuan Wu Shujian Wu +6 位作者 Xiuying Liu Shuze Chen Senbao Xu Yunying Gong Qiujuan Ye Xuefeng Gao Ye Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1702-1717,共16页
The Agrocybe cylindracea polysaccharides(ACP)have been shown to possess various health benefits.However,the anti-inflammatory effects of ACP and the mechanisms underlying these effects remain poorly understood.In this... The Agrocybe cylindracea polysaccharides(ACP)have been shown to possess various health benefits.However,the anti-inflammatory effects of ACP and the mechanisms underlying these effects remain poorly understood.In this study,we delved into the potential of ACP in mitigating colitis induced by dextrose sodium sulfate(DSS)in C57BL/6J mice and explored the associated mechanisms.ACP demonstrated notable antiinflammatory effects in the intestines,as evidenced by the restoration of various indicators such as increased body weight and colon length,decreased disease activity index(DAI)score,and alleviation of pathological damage in the colon.Additionally,ACP upregulated the expression of ZO-1,Occludin,and Muc2,suggesting a restoration of the mechanical and mucus barriers of the intestinal mucosa.Furthermore,ACP facilitated the polarization of M2 macrophages and preserved intestinal immune balance.The impact of ACP on the biological barrier was further scrutinized.ACP ameliorated disruptions in the gut microbiota,particularly by enhancing the relative abundance of bacteria that produce short-chain fatty acids(Anaerostipes,Romboutsia,and Butyricicoccus).Remarkably,the ameliorative effects of ACP on colitis were compromised upon the removal of the microbial community,but were restored post fecal microbiota transplantation(FMT),indicating that the efficacy of ACP in alleviating colitis is dependent on the gut microbiota.Intriguingly,the regulatory influence of ACP on macrophages also hinged on the gut microbiota.In essence,ACP exhibits the potential to modulate the composition of the gut microbiota,fostering the growth of beneficial bacteria,which in turn promotes the polarization of colonic M2 macrophages and facilitates the repair of the intestinal mucosal barrier in DSS-induced colitis.These findings underscore the capacity of ACP to enhance the intestinal mucosal barrier and ameliorate colitis by modulating the gut microbiota-macrophage axis,suggesting that ACP could serve as a functional food supplement for preserving intestinal homeostasis and preventing colitis. 展开更多
关键词 Agrocybe cylindracea polysaccharides Ulcerative colitis Gut microbiota M2 macrophage polarization Intestinal mucosal barrier
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