基于Web of Science(科学引文索引数据库)核心合集收录的160篇论文,运用CiteSpace(可视化文献分析软件)进行可视化分析,探求国外服刑人员未成年子女研究的现状和发展脉络。当前国外服刑人员未成年子女研究大致可分为萌芽期(1990年至2000...基于Web of Science(科学引文索引数据库)核心合集收录的160篇论文,运用CiteSpace(可视化文献分析软件)进行可视化分析,探求国外服刑人员未成年子女研究的现状和发展脉络。当前国外服刑人员未成年子女研究大致可分为萌芽期(1990年至2000年)、起步期(2001年至2010年)、发展期(2011年至今)三个阶段。研究机构呈现分散的状态,多为独立研究,各机构之间的合作较少。研究的主题和热点为父母服刑对其子女的影响、对策建议,服刑人员未成年子女心理问题的干预研究。今后的研究应关注该群体心理创伤影响及创伤的干预治疗。展开更多
In accordance with previous reports, the sequences related to phosporylated protein segments occur in conserved variable domains of immunoglobulins including first of all certain N-terminally located segments. Consequ...In accordance with previous reports, the sequences related to phosporylated protein segments occur in conserved variable domains of immunoglobulins including first of all certain N-terminally located segments. Consequently, we look here for the sequences 1) composing human and mouse proteins different from antigen receptors, 2) identical with or highly similar to nucleotide sequence representatives of conserved variable immunoglobulin segments and 3) identical with or closely related to phosphorylation sites. More precisely, we searched for the corresponding actual pairs of DNA and protein sequence segments using five-step bilingual approach employing among others a) different types of BLAST searches, b) two in-principle-different machine-learning methods predicting phosphorylated sites and c) two large databases recording existing phosphorylation sites. The approach identified seven existing phosphorylation sites and thirty-seven related human and mouse segments achieving limits for several predictions or phylogenic parameters. Mostly serines phosporylated with ataxia-telangiectasia-related kinase (involved in regulation of DNA-double-strand-break repair) were indicated or predicted in this study. Hypermutation motifs, located in effective positions of the selected sequence segments, occurred significantly less frequently in transcribed than non-transcribed DNA strands suggesting thus the incidence of mutation events. In addition, marked differences between the numbers and proportions of human and mouse cancer-related sequence items were found in different steps of selection process. The possible role of hypermutation changes within the selected segments and the observed structural relationships are discussed here with respect to DNA damage, carcinogenesis, cancer vaccination, ageing and evolution. Taken together, our data represent additional and sometimes perhaps complementary information to the existing databases of empirically proven phosphorylation sites or pathogenically important spots.展开更多
摘要基于Web of Science(科学引文索引数据库)核心合集收录的160篇论文,运用CiteSpace(可视化文献分析软件)进行可视化分析,探求国外服刑人员未成年子女研究的现状和发展脉络。当前国外服刑人员未成年子女研究大致可分为萌芽期(1990年至2000年)、起步期(2001年至2010年)、发展期(2011年至今)三个阶段。研究机构呈现分散的状态,多为独立研究,各机构之间的合作较少。研究的主题和热点为父母服刑对其子女的影响、对策建议,服刑人员未成年子女心理问题的干预研究。今后的研究应关注该群体心理创伤影响及创伤的干预治疗。
摘要In accordance with previous reports, the sequences related to phosporylated protein segments occur in conserved variable domains of immunoglobulins including first of all certain N-terminally located segments. Consequently, we look here for the sequences 1) composing human and mouse proteins different from antigen receptors, 2) identical with or highly similar to nucleotide sequence representatives of conserved variable immunoglobulin segments and 3) identical with or closely related to phosphorylation sites. More precisely, we searched for the corresponding actual pairs of DNA and protein sequence segments using five-step bilingual approach employing among others a) different types of BLAST searches, b) two in-principle-different machine-learning methods predicting phosphorylated sites and c) two large databases recording existing phosphorylation sites. The approach identified seven existing phosphorylation sites and thirty-seven related human and mouse segments achieving limits for several predictions or phylogenic parameters. Mostly serines phosporylated with ataxia-telangiectasia-related kinase (involved in regulation of DNA-double-strand-break repair) were indicated or predicted in this study. Hypermutation motifs, located in effective positions of the selected sequence segments, occurred significantly less frequently in transcribed than non-transcribed DNA strands suggesting thus the incidence of mutation events. In addition, marked differences between the numbers and proportions of human and mouse cancer-related sequence items were found in different steps of selection process. The possible role of hypermutation changes within the selected segments and the observed structural relationships are discussed here with respect to DNA damage, carcinogenesis, cancer vaccination, ageing and evolution. Taken together, our data represent additional and sometimes perhaps complementary information to the existing databases of empirically proven phosphorylation sites or pathogenically important spots.