“What are you/we talking about?”是英语口语交际中常见的习语构式,不仅具有规约意义和语境制约下的语用意义,而且用来调节和管理前述话语与交际行为,属于元语用意识指示语。本文基于元语用理论,通过分析美国当代英语语料库口语子库...“What are you/we talking about?”是英语口语交际中常见的习语构式,不仅具有规约意义和语境制约下的语用意义,而且用来调节和管理前述话语与交际行为,属于元语用意识指示语。本文基于元语用理论,通过分析美国当代英语语料库口语子库中构式“What are you/we talking about?”的语用意义,揭示其在不同语境下说话人的元语用意识体现。研究发现,构式“What are you/we talking about?”体现说话人对交际中语篇、信息、发话人和交际双方四个维度的元语用意识,具体表现在管理话语组织结构,为听话人提供认知解读框架,构建权威身份,管理人际亲疏关系。本研究拓展了构式研究的理论视角,对构式的元语用阐释有助于我们更全面地推理和解读说话人的交际意图。展开更多
OBJECTIVE Mu-Xiang-You-Fang(MXYF)is a classic prescription of Hui medicine,composed of five herbs,which has been used to treat ischemic stroke for many years.However,the potential pharmacological mecha⁃nisms of MXYF r...OBJECTIVE Mu-Xiang-You-Fang(MXYF)is a classic prescription of Hui medicine,composed of five herbs,which has been used to treat ischemic stroke for many years.However,the potential pharmacological mecha⁃nisms of MXYF remain unclear.The present research is to investigate the neuroprotective effect of MXYF and its role in modulating autophagy via AMPK/mTOR signaling pathway in the PC12 oxygen-glucose deprivation and reperfusion(OGD/R)injury model.METHODS MXYF was extracted by supercritical CO2 fluid extraction apparatus.PC12 OGD/R injury model was established by oxygen-glucose deprivation for 2 h and reperfusion for 24 h.The effects of MXYF on the viability and cytotoxicity of PC12 cells were determined through cell counting kit(CCK-8)assay.Colorimetric method was performed to determine the LDH leakage rate.The calcium concentration was determined by chemical fluorescence method and the mitochondrial membrane potential was determined through flow cytometry.Monodansylcadaverine(MDC)staining was conducted to detect autophagosome formation.The expression of LC3,Beclin1,p62,p-AMPK,ULK1,p-mTOR and p-p70s6k proteins were determined by immunofluorescence and Western blotting analyses.RESULTS MXYF(1,2 and 4 mg·L^-1)could significantly increase the cell viability and mitochondrial membrane potential,while decreased the release of lactate dehydrogenase(LDH)and calcium concentration in PC12 cells.Mechanistic studies showed that MXYF reduced the LC3-II/LC3-I ratio and inhibited the expression of beclin1,p-AMPK and ULK1.In comparison,the expres⁃sion of p-mTOR,p-p70s6k and p62 were significantly enhanced.CONCLUSION MXYF inhibits autophagy after OGD/Rinduced PC12 cell injury through AMPK-mTOR pathway,thus MXYF might have therapeutic potential for treating the ischemic stroke.展开更多
针对基于You Only Look Once v2算法的目标检测存在精度低及稳健性差的问题,提出一种车辆目标实时检测的You Only Look Once v2优化算法;该算法以You Only Look Once v2算法为基础,通过增加网络深度,增强特征提取能力,同时,通过添加残...针对基于You Only Look Once v2算法的目标检测存在精度低及稳健性差的问题,提出一种车辆目标实时检测的You Only Look Once v2优化算法;该算法以You Only Look Once v2算法为基础,通过增加网络深度,增强特征提取能力,同时,通过添加残差模块,解决网络深度增加带来的梯度消失或弥散问题;该方法将网络结构中低层特征与高层特征进行融合,提升对小目标车辆的检测精度。结果表明,通过在KITTI数据集上进行测试,优化后的算法在检测速度不变的情况下,提高了车辆目标检测精度,平均精度达到0.94,同时提升了小目标检测的准确性。展开更多
由吉米.戴维斯和查尔斯.米切尔合作谱曲填词、吉米.戴维斯在1940年2月4日录制的英语歌曲You Are My Sunshine在当时非常流行,甚至成了英国国王乔治六世的最爱。它为什么那么成功?目前,歌曲的语言学研究有一些,但尚无对这首歌词的分析。...由吉米.戴维斯和查尔斯.米切尔合作谱曲填词、吉米.戴维斯在1940年2月4日录制的英语歌曲You Are My Sunshine在当时非常流行,甚至成了英国国王乔治六世的最爱。它为什么那么成功?目前,歌曲的语言学研究有一些,但尚无对这首歌词的分析。本文运用系统功能语法的经验功能对它进行分析后发现,与现有研究发现的歌曲以物质过程为主不同,这首歌词的过程类型以心理过程和关系过程为主,所有过程都是表达爱意的心理活动和双方关系的典型动词,令人倍感亲切和难忘,这是这首歌曲成功的语言因素之一。此外,文章还就分析结论及其不足等方面进行了一些简单的讨论。展开更多
This article presents a comprehensive analysis of the current state of research on the English translation of Lu You’s poetry, utilizing a data sample comprising research papers published in the CNKI Full-text Databa...This article presents a comprehensive analysis of the current state of research on the English translation of Lu You’s poetry, utilizing a data sample comprising research papers published in the CNKI Full-text Database from 2001 to 2022. Employing rigorous longitudinal statistical methods, the study examines the progress achieved over the past two decades. Notably, domestic researchers have displayed considerable interest in the study of Lu You’s English translation works since 2001. The research on the English translation of Lu You’s poetry reveals a diverse range of perspectives, indicating a rich body of scholarship. However, several challenges persist, including insufficient research, limited translation coverage, and a noticeable focus on specific poems such as “Phoenix Hairpin” in the realm of English translation research. Consequently, there is ample room for improvement in the quality of research output on the English translation of Lu You’s poems, as well as its recognition within the academic community. Building on these findings, it is argued that future investigations pertaining to the English translation of Lu You’s poetry should transcend the boundaries of textual analysis and encompass broader theoretical perspectives and research methodologies. By undertaking this shift, scholars will develop a more profound comprehension of Lu You’s poetic works and make substantive contributions to the field of translation studies. Thus, this article aims to bridge the gap between past research endeavors and future possibilities, serving as a guide and inspiration for scholars to embark on a more nuanced and enriching exploration of Lu You’s poetry as well as other Chinese literature classics.展开更多
摘要“What are you/we talking about?”是英语口语交际中常见的习语构式,不仅具有规约意义和语境制约下的语用意义,而且用来调节和管理前述话语与交际行为,属于元语用意识指示语。本文基于元语用理论,通过分析美国当代英语语料库口语子库中构式“What are you/we talking about?”的语用意义,揭示其在不同语境下说话人的元语用意识体现。研究发现,构式“What are you/we talking about?”体现说话人对交际中语篇、信息、发话人和交际双方四个维度的元语用意识,具体表现在管理话语组织结构,为听话人提供认知解读框架,构建权威身份,管理人际亲疏关系。本研究拓展了构式研究的理论视角,对构式的元语用阐释有助于我们更全面地推理和解读说话人的交际意图。
基金National Natural Science Foundation of China(8166070081260679)Ningxia College FirstClass Discipline Construction Project(Chinese Medicine)Funded Project(NXYLXK2017A06)
摘要OBJECTIVE Mu-Xiang-You-Fang(MXYF)is a classic prescription of Hui medicine,composed of five herbs,which has been used to treat ischemic stroke for many years.However,the potential pharmacological mecha⁃nisms of MXYF remain unclear.The present research is to investigate the neuroprotective effect of MXYF and its role in modulating autophagy via AMPK/mTOR signaling pathway in the PC12 oxygen-glucose deprivation and reperfusion(OGD/R)injury model.METHODS MXYF was extracted by supercritical CO2 fluid extraction apparatus.PC12 OGD/R injury model was established by oxygen-glucose deprivation for 2 h and reperfusion for 24 h.The effects of MXYF on the viability and cytotoxicity of PC12 cells were determined through cell counting kit(CCK-8)assay.Colorimetric method was performed to determine the LDH leakage rate.The calcium concentration was determined by chemical fluorescence method and the mitochondrial membrane potential was determined through flow cytometry.Monodansylcadaverine(MDC)staining was conducted to detect autophagosome formation.The expression of LC3,Beclin1,p62,p-AMPK,ULK1,p-mTOR and p-p70s6k proteins were determined by immunofluorescence and Western blotting analyses.RESULTS MXYF(1,2 and 4 mg·L^-1)could significantly increase the cell viability and mitochondrial membrane potential,while decreased the release of lactate dehydrogenase(LDH)and calcium concentration in PC12 cells.Mechanistic studies showed that MXYF reduced the LC3-II/LC3-I ratio and inhibited the expression of beclin1,p-AMPK and ULK1.In comparison,the expres⁃sion of p-mTOR,p-p70s6k and p62 were significantly enhanced.CONCLUSION MXYF inhibits autophagy after OGD/Rinduced PC12 cell injury through AMPK-mTOR pathway,thus MXYF might have therapeutic potential for treating the ischemic stroke.
摘要针对基于You Only Look Once v2算法的目标检测存在精度低及稳健性差的问题,提出一种车辆目标实时检测的You Only Look Once v2优化算法;该算法以You Only Look Once v2算法为基础,通过增加网络深度,增强特征提取能力,同时,通过添加残差模块,解决网络深度增加带来的梯度消失或弥散问题;该方法将网络结构中低层特征与高层特征进行融合,提升对小目标车辆的检测精度。结果表明,通过在KITTI数据集上进行测试,优化后的算法在检测速度不变的情况下,提高了车辆目标检测精度,平均精度达到0.94,同时提升了小目标检测的准确性。
摘要由吉米.戴维斯和查尔斯.米切尔合作谱曲填词、吉米.戴维斯在1940年2月4日录制的英语歌曲You Are My Sunshine在当时非常流行,甚至成了英国国王乔治六世的最爱。它为什么那么成功?目前,歌曲的语言学研究有一些,但尚无对这首歌词的分析。本文运用系统功能语法的经验功能对它进行分析后发现,与现有研究发现的歌曲以物质过程为主不同,这首歌词的过程类型以心理过程和关系过程为主,所有过程都是表达爱意的心理活动和双方关系的典型动词,令人倍感亲切和难忘,这是这首歌曲成功的语言因素之一。此外,文章还就分析结论及其不足等方面进行了一些简单的讨论。
摘要This article presents a comprehensive analysis of the current state of research on the English translation of Lu You’s poetry, utilizing a data sample comprising research papers published in the CNKI Full-text Database from 2001 to 2022. Employing rigorous longitudinal statistical methods, the study examines the progress achieved over the past two decades. Notably, domestic researchers have displayed considerable interest in the study of Lu You’s English translation works since 2001. The research on the English translation of Lu You’s poetry reveals a diverse range of perspectives, indicating a rich body of scholarship. However, several challenges persist, including insufficient research, limited translation coverage, and a noticeable focus on specific poems such as “Phoenix Hairpin” in the realm of English translation research. Consequently, there is ample room for improvement in the quality of research output on the English translation of Lu You’s poems, as well as its recognition within the academic community. Building on these findings, it is argued that future investigations pertaining to the English translation of Lu You’s poetry should transcend the boundaries of textual analysis and encompass broader theoretical perspectives and research methodologies. By undertaking this shift, scholars will develop a more profound comprehension of Lu You’s poetic works and make substantive contributions to the field of translation studies. Thus, this article aims to bridge the gap between past research endeavors and future possibilities, serving as a guide and inspiration for scholars to embark on a more nuanced and enriching exploration of Lu You’s poetry as well as other Chinese literature classics.