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The evolving burden of heart failure in China:a 34-year subnational analysis of trends and causes from the Global Burden of Disease Study 2023 认领 引用 被引量：8
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作者 Xuan Yang Zhen-Ping Zhao +4 位作者 Yu Shi Gui-Yuan Han Yan Xu Yi-Chong Li Mai-Geng Zhou 《Military Medical Research》 SCIE CAS CSCD 2026年第3期413-425,共13页
Background:Heart failure(HF)continues to be a public health issue in China with population aging and increasing disease drivers.The burden,spatial patterns,temporal trends,and underlying causes of HF in China at subna... Background:Heart failure(HF)continues to be a public health issue in China with population aging and increasing disease drivers.The burden,spatial patterns,temporal trends,and underlying causes of HF in China at subnational levels remain inadequately understood.This study aims to assess the disease burden and causes of HF,and their regional disparities in China from 1990 to 2023.Methods:Utilizing the estimates from the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2023,we assessed the prevalence and years lived with disability(YLDs)of HF and their trends in China at both national and subnational levels.Estimates were also compared by disease severity,sex,age group,cause,and region.Results:In 2023,China had an estimated 14.3 million HF cases,marking a significant 208.4% increase over the past three decades.Ischemic heart disease(IHD)has become the top cause of HF,compared with 1990,with hypertensive heart disease(HHD)at the top.Alongside chronic obstructive pulmonary disease(COPD),these three leading causes accounted for 77.4%of all HF cases.The burden of HF due to IHD and COPD exhibited distinct regional patterns and substantial disparities:regions in northern China exhibited notably higher age-standardized YLDs rates for HF due to IHD,while provinces in the western regions faced the highest burden from COPD.Six provinces with the highest tertile of YLDs rates in 2023 also experienced the most pronounced increases between 1990 and 2023.Conclusions:HF remains a significant public health challenge in China,with a marked increase in prevalence over the past three decades.The substantial regional variations highlight the need for targeted and region-specific public health strategies.Enhanced nationwide efforts should be made to reduce the geographical disparities in the burden of HF. 展开更多
关键词 Heart failure(HF) China Global Burden of Diseases Epidemiology
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Experimental study on damage evolution and failure precursor characteristics of granite under thermal shock cycles 认领 引用 被引量：2
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作者 Zhenjiang Huang Mingxuan Shen +5 位作者 Yu Zhao Chaolin Wang Jing Bi Yongfa Zhang Shuang Dang Yuhang Zhao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2026年第1期125-148,共24页
Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens un... Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens under varying temperature and cycle conditions,employing acoustic emission monitoring,digital image correlation,and three-dimensional scanning technology.A systematic analysis was conducted on the patterns of damage evolution,failure precursor,and response mechanisms under combined thermal and cyclic loading.Experimental results show that both P-wave velocity and tensile strength degrade significantly with increasing temperature and cycle count,with temperature having a more pronounced effect than cycle count.Notably,damage evolution exhibits a dual-threshold behavior in which degradation accelerates markedly above 400℃ and stabilizes after 5 thermal cycles.Fracture surfaces evolve from initially planar to rugged morphologies,with peak-valley height differences at 600℃ being approximately three times greater than those at 200℃.Furthermore,based on acoustic emission energy entropy analysis,we introduce a novel failure precursor indicator where the sustained increase and critical surge in average entropy serve as reliable early-warning signals for impending rock failure.These findings establish a solid theoretical basis and practical methodology for damage assessment and instability early-warning systems in high-temperature rock engineering. 展开更多
关键词 Granite Thermal shock cycles Acoustic emission Thermal damage Failure precursor
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Effect of dynamic disturbance frequency on brittle failure of granite in deep excavation 认领 引用 被引量：2
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作者 Ben-Guo He Hanyi Liu +1 位作者 Xia-Ting Feng Hongyuan Fu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第2期1002-1015,共14页
Dynamic disturbances with various frequencies could trigger different failure modes of deep excavations.Superimposed on this static stress are dynamic disturbances due to various dynamic vibrations,e.g.excavation blas... Dynamic disturbances with various frequencies could trigger different failure modes of deep excavations.Superimposed on this static stress are dynamic disturbances due to various dynamic vibrations,e.g.excavation blasting,blasting,tunnel boring machine(TBM)vibration,rockburst wave,earthquakes.Specifically,these dynamic sources are characterized by a wide range of wave frequencies f,resulting in differences in failure modes.A series of true-triaxial compression tests were conducted on granite to simulate the excavation-induced stress path in three-dimensional(3D)stresses.Subsequently,a dynamic disturbance with various frequencies was applied to a cuboid specimen,to reveal the behavior associated with brittle failure.The dynamic disturbance with frequencies f of 5 Hz,10 Hz,and 40 Hz generates less disturbed energy components in the granite together with higher peak strength.However,dynamic disturbances with f of 20 Hz and 30 Hz resulted in a lower peak strength;the peak strength of the rock increases sp albeit it decreases at first,then increases.This U-shaped phenomenon relates to the natural frequency of the granite under such stress conditions.Different rock lithologies consisting of diverse mineral composition,respond differently to each sensitive resonance frequency.Interestingly,the weak disturbance stress with a high frequency f and low amplitude A increases the ratio of crack damage to peak strength(scd/sp)in the granite.This leads to the inhibition of the expansion of the granite during the dynamic disturbance process.Multiple penetrating tensileeshear cracks appear in the s3-direction as the disturbance frequency f increases. 展开更多
关键词 True-triaxial compression Disturbance frequency Brittle failure Characteristic strength Deep excavation
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Pullout response and failure characteristics of anchorage system in hard rocks 认领 引用 被引量：1
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作者 Chuanqing Zhang Qiangqiang Zhang +2 位作者 Qiang Cui Xunguo Zhu Qiming Xie 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第3期1966-1991,共26页
The axial load-bearing capacity of grouted anchorage systems is critical for rock reinforcement and reflects the interactions among system components.Hence,the mechanical response and failure characteristics of the an... The axial load-bearing capacity of grouted anchorage systems is critical for rock reinforcement and reflects the interactions among system components.Hence,the mechanical response and failure characteristics of the anchorage system under axial loading are of vital importance.They serve as the foundation for establishing the mechanical model of the anchorage system and provide significant guidance for the optimization design of bolts and the assessment of anchorage conditions.However,as the most widely used research method,current pullout tests have not paid sufficient attention to simulating actual rock mass stiffness,have not fully revealed the radial mechanical response during the pullout process,and have not clarified the locations and modes of pullout failure.To address these issues,a testing method simulating hard rock stiffness and strength was developed using elasticity and stiffness equivalence theories.Tests revealed three anchorage failure modes under equivalent hard rock stiffness:tooth cutting,sliding,and sliding-tooth cutting composite failure,with the composite failure being dominant.The pullout load-displacement curves exhibited bimodal patterns for composite failure and single peaks for tooth cutting and sliding failures.Post-peak softening showed up-convex curves for tooth cutting and down-concave curves for sliding failure,while bolt yielding displayed distinct plateaus.The radial stress trends at the rock-grout interface paralleled pullout load curves,with sliding failure exhibiting approximately 10 MPa lower peak radial stress compared to tooth cutting failure.Anchorage length most strongly affected peak load,while grout properties predominantly governed failure mode. 展开更多
关键词 Anchorage system Pullout test Failure characteristics Mechanical responses Stiffness
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Prediction model for indoor rock compression failure time based on ensemble learning and optimization algorithms 认领 引用 被引量：1
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作者 Boyang Zhang Xiancheng Wang +5 位作者 Fei Ding Liyuan Yu Luyuan Wu Shuai Zhao Yingkang Weng Zhaoyang Feng 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第7期2437-2453,共17页
The prediction of rock failure,a key fundamental research for addressing mining safety issues(such as mine slope stability and rockburst),faces challenges with traditional methods due to their complex generalization a... The prediction of rock failure,a key fundamental research for addressing mining safety issues(such as mine slope stability and rockburst),faces challenges with traditional methods due to their complex generalization and computational processes that struggle to describe the entire failure process.Consequently,12 prediction models integrating ensemble learning and optimization algorithms were established to predict rock peak stress and failure time using strain,elastic modulus,density,mass,and confining pressure as inputs.Fivefold cross-validation was used to optimize hyperparameters,significantly improving the model's generalization ability,robustness,and stability.Dataset was established through rock mechanics experiments,with strain increments configured at 0.008‰,0.01‰,and 0.012‰ in the test set.The cross-validation optimized particle swarm optimization eXtreme gradient boosting(CV-PSO-XGBoost)model performed best under a strain increment of 0.01‰,and its stress prediction achieved coefficient of determination R2=0.904,mean absolute error(MAE)=4.315,and root mean square error(RMSE)=5.435;while the failure time prediction demonstrated R2=0.811,mean absolute percentage error(MAPE)=7.842%,and MAE=30.343.Finally,SHapley Additive explanations(SHAP)analysis showed strain and stress significantly impact the model,with strain positively predicting failure time,aligning with traditional rock validating reliability.This study provides insights into the research on rock strata stability in mining. 展开更多
关键词 rock failure strain increment failure time ensemble learning SHapley Additive exPlanations interpretation
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Study on the failure mechanism of the shield excavation face in the sandy cobble stratum under different buried depths 认领 引用 被引量：1
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作者 Hua Jiang Chongyang Liu +2 位作者 Ao Zhang Xiaoyan Zhang Yuhang Li 《Deep Underground Science and Engineering》 EI CAS CSCD 2026年第2期410-425,共16页
One of the significant challenges faced in shield tunnel construction is the risk of collapse resulting from abrupt changes in soil conditions in advance of the working face,particularly within the sandy cobble stratu... One of the significant challenges faced in shield tunnel construction is the risk of collapse resulting from abrupt changes in soil conditions in advance of the working face,particularly within the sandy cobble stratum.This study aims to effectively manage these sudden variations and to further investigate the failure mechanisms associated with shield tunneling.The limit support pressure,instability patterns,and soil arch ranges at the excavation face under varying burial depths were analyzed using PFC3D discrete element software,specifically in relation to the shield section of the Beijing Subway New Airport Line 06 cigezhuang~1#wind shaft project.The findings of this research indicate the following:(1)The limit support pressure at the shield excavation face in sandy cobble strata increases with the burial depth ratio;however,the ratio of the limit support pressure decreases as the burial depth ratio increases.(2)A burial depth ratio threshold of 1.0–1.5 suggests that no soil arch forms in the stratum ahead of the excavation face when the burial depth ratio is below this range.Conversely,a soil arch develops when the burial depth ratio exceeds this threshold.(3)When the burial depth ratio is less than the threshold range of 1.0–1.5,the longitudinal instability zone transitions from a wedge shape to a barrel shape,extending to the surface.Conversely,when the burial depth ratio surpasses this range,the longitudinal instability zone changes from a wedge shape to a bulb shape and does not extend to the surface.(4)This paper proposes a calculation model for determining the limit support pressure of the excavation face under both shallow and deep burial conditions in the sandy cobble stratum,providing a calculation formula for the limit support pressure and establishing a reference range for the calculation parameters. 展开更多
关键词 calculation model failure mechanism numerical simulation sandy cobble stratum shield excavation face
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Anisotropic failure characteristics of slate tunnels under large in situ stress 认领 引用 被引量：1
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作者 Song Lu Dingli Zhang +4 位作者 Zhenyu Sun Xuanhao Chen Jiachen Wang Xu Chen Jianlin Zhu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第4期2634-2652,共19页
Significantsqueezing deformation in deep soft-rock tunnels often arises from large stress concentrations around underground excavations,threatening support integrity in layered rock masses with pronounced anisotropy.T... Significantsqueezing deformation in deep soft-rock tunnels often arises from large stress concentrations around underground excavations,threatening support integrity in layered rock masses with pronounced anisotropy.This study firstinvestigated the physical and mechanical properties of the carbonaceous slate interbedded with sandstone,identifying four failure modes:splitting,shearing,sliding,and rotation.The discrete element method was subsequently employed to calibrate the numerical models based on the derived ratio relationships of rock mass parameters and fieldobservations.The model was then applied to reproduce the tunnel excavation process and quantify the anisotropic deformation.The impact of critical parameters on the distribution of deformation and failure modes(i.e.jointed and non-jointed yielding plastic zones)was investigated.Ultimately,fieldmonitoring of the primary support was conducted to validate the numerical simulation predictions regarding the mechanical behavior of the surrounding rock and support performance.The results indicated that both larger bedding angle and increased lateral pressure coefficientcontributed to the amplificationof haunch convergence.When the bedding angle exceeded 45◦,the non-jointed yielding plastic zone was more sensitive to changes in lateral pressure coefficient.For bedding angles at or below 45◦,the jointed yielding plastic zone was more affected.The haunch convergence and jointed failure intensifiedwith increasing excavation-bedding intersection angles.Sensitivity analyses revealed that block cohesion exerted greater control on deformation and failure than joint cohesion did.These insights advance the management of large anisotropic deformations in slate tunnels and provide a foundation for proactive risk-mitigation measures. 展开更多
关键词 Large anisotropic deformation Layered slate property Large in situ stress Failure mode Tunnel response Field test
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Failure mechanism of the coal wall at the working face based on an eccentric compression mechanical model 认领 引用
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作者 Maolin Tian Jiabao Wang +4 位作者 Changsheng Wang Shijie Sun Lijun Han Qingbin Meng Sunhao Zhang 《Deep Underground Science and Engineering》 EI CAS CSCD 2026年第1期127-143,共17页
The deformation and failure of coal walls in front of a working face cause significant difficulties during mining operations.This study reveals the nonuniform distribution of bearing pressure in front of coal walls ba... The deformation and failure of coal walls in front of a working face cause significant difficulties during mining operations.This study reveals the nonuniform distribution of bearing pressure in front of coal walls based on in situ monitoring data and numerical simulation.Therefore,an eccentric compression mechanical model was established to study the deformation and failure characteristics of a coal wall.The slenderness ratio of the compression bar is introduced to define coal walls.The results showed that instability failure occurs when λ>λc and material failure occurs when λ≤λc.The instability failure-type coal wall spalling was related to the mining height,eccentricity of roof pressure,the horizontal force,and the reaction moment of the floor.The material failure-type coal wall spalling was related to the cohesion,the internal friction angle of the coal,the upper pressure,and the horizontal force of coal walls.Unstable and destructive coal wall peeling usually occurs at a height of 0.5–0.6 times the mining height,while material damage to coal wall peeling is determined to occur within the range of 0.4-0.6 times the mining depth.The findings contribute to the understanding of the deformation and failure of coal walls. 展开更多
关键词 coal wall spalling eccentric compression mechanical model failure mechanism instability failure shear failure
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System reliability analysis of jointed bedding rock slopes under seismic loading:Integrating multiple failure modes 认领 引用
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作者 ZHANG Yingbin CHEN Haiping +3 位作者 FU Junwen LI Dejian LI Hekai YU Qiangshan 《Journal of Mountain Science》 SCIE CSCD 2026年第5期2074-2087,I0007-I0010,共14页
Jointed bedding rock slopes are susceptible to multiple failure modes under seismic loading,yet conventional stability assessments relying on a single mode are insufficient and may introduce significant errors,potenti... Jointed bedding rock slopes are susceptible to multiple failure modes under seismic loading,yet conventional stability assessments relying on a single mode are insufficient and may introduce significant errors,potentially underestimating slope instability risk.This study established a novel system reliability framework,integrating four key failure modes—translational(TM),rotational(RM),upper rotationallower translational(URLTM),and upper translationallower rotational(UTLRM)—for seismic stability assessment.Utilizing Monte Carlo simulation,the framework explicitly accounted for inherent randomness and uncertainty in the strength parameters of joint surfaces and rock bridges.System reliability was evaluated using the minimum safety factor(FS)to identify the dominant failure mode.The analysis reveals that using only a single failure model can introduce maximum errors in Fs exceeding 10%;with increasing cr(cohesion)andφr(internal friction angle),the dominant failure mode changes from RM(not affected by the joint surface)to UTLRM/TM(controlled by the joint surface);as Kc(cohesion weakening coefficient)and Kφ(friction coefficient(tanφr)weakening coefficient)increase,failure is more likely atδ/β(joint surface angle/slope angle)=0.40~0.65;seismic action further increases the likelihood of joint-surface-controlled failure,increasing seismic action shifts the dominant failure mode from UTLRM to TM.These results offer direct support for the efficient determination of the dominant failure mode and sliding surface position in stability assessments of jointed bedding rock slopes. 展开更多
关键词 Jointed bedding rock slopes Multiple failure modes System reliability Monte Carlo Dominant failure mode
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Transmission patterns of progressive damage and reliability analysis of reservoir-induced landslides considering local tensile failure 认领 引用
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作者 Minghao Miao Huiming Tang +5 位作者 Yinlong Jiang Kun Fang Changdong Li Cheng He Peng Cao Sha Lu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第2期913-931,共19页
Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the ten... Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk. 展开更多
关键词 Reliability analysis Tensile failure Reservoir landslide Progressive damage Failure mode Tensile crack
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Navigating the therapeutic tightrope:Precision use of plasmapheresis and continuous renal replacement therapy in liver failure 认领 引用
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作者 Manish Manrai Aditya V Pachisia +2 位作者 Saurabh Dawra Siddharth Shukla Atul A Jha 《World Journal of Hepatology》 2026年第5期69-88,共20页
Liver failure,which includes acute liver failure(ALF)and acute-on-chronic liver failure(ACLF),is a life-threatening condition characterised by severe loss of hepatocytes,systemic inflammation,and multi-organ dysfuncti... Liver failure,which includes acute liver failure(ALF)and acute-on-chronic liver failure(ACLF),is a life-threatening condition characterised by severe loss of hepatocytes,systemic inflammation,and multi-organ dysfunction,often leading to mortality rates exceeding 50%.Therapeutic plasma exchange(TPE,also known as plasmapheresis)and continuous renal replacement therapy(CRRT)are essential extracorporeal treatments that detoxify the blood,stabilise patients,and act as a bridge to recovery or transplantation.The debate surrounding the use of TPE and CRRT in liver failure(ALF and ACLF)is ongoing,with a recognised need to clearly define the patient groups,timing,and modality of application.This minireview synthesises evidence from 2016 to 2025,obtained from PubMed,EMBASE,and the Cochrane databases,and examines the mechanisms,indications,protocols,and outcomes of TPE and CRRT in ALF and ACLF.Correct patient selection,timing,and monitoring are essential to optimise benefits while minimising risks such as bleeding,infections,or citrate toxicity.This review examines various aspects of both therapies to help determine the most suitable treatment for liver failure.It highlights the importance of standardised guidelines to improve outcomes across different settings. 展开更多
关键词 Acute liver failure Acute-on-chronic liver failure Therapeutic plasma exchange Continuous renal replacement therapy Extracorporeal therapies Multiorgan failure
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Dual-function oral nanotherapeutic mitigates sepsis-like multi-organ failure by targeting inflammatory and fibrotic pathways 认领 引用
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作者 James Asenso Neha Choudhury +3 位作者 Raghu Ganugula Tyler Posey Meenakshi Arora M.N.V.Ravi Kumar 《Bioactive Materials》 SCIE CSCD 2026年第8期34-46,共13页
Sepsis,a life-threatening condition,often leads to multi-organ failure and has limited treatment options.We developed a novel dual-function nanoparticle,P2Ns-NAR(NAR),which utilizes naringenin(NAR)as both a targeting ... Sepsis,a life-threatening condition,often leads to multi-organ failure and has limited treatment options.We developed a novel dual-function nanoparticle,P2Ns-NAR(NAR),which utilizes naringenin(NAR)as both a targeting ligand for gut folate receptors and an encapsulated therapeutic agent to overcome its poor oral bioavailability.Here,we investigated the efficacy of this oral formulation in a mouse model of lipopolysaccharide-induced sepsis.We observed a significant reduction in the mRNA expression of pro-inflammatory(Tlr4,NF-κB,and IL-18),apoptotic(p53,and Fas),fibrosis(TGFβ1 and Smad3)and inflammasome-related(P2x7,gasdermin D,Nlrp3,Caspase 1,Nek7)markers.Histological analyses showed a prevention of tissue injury in the lungs,liver,kidney,heart,brain,intestines,and spleen.Additionally,Masson's trichrome staining revealed a remarkable reduction in collagen deposition,a hallmark of fibrosis,across multiple organs such as the lungs,liver,kidney,and heart.Our findings establish this dual-function nanoparticle platform as a highly effective oral therapy to prevent multi-organ failure. 展开更多
关键词 Immunomodulation Multi-organ failure Naringenin Oral nanoparticle Sepsis
Mitochondrial dysfunction: a new target for traditional Chinese medicine in the treatment of chronic heart failure 认领 引用
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作者 Fuyun Jia Yadong Wang +8 位作者 Shengwei Gao Rui Zhang Shichuan Chen Hui Zhang Yinan Ma Zhengwei Zhang Junchi Guo Xi Zhang Qiang Xu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期289-299,共11页
Chronic heart failure(CHF) remains a global health challenge with limited therapeutic options. Mitochondrial dysfunction is a key pathological feature, and traditional Chinese medicine(TCM) shows unique potential in t... Chronic heart failure(CHF) remains a global health challenge with limited therapeutic options. Mitochondrial dysfunction is a key pathological feature, and traditional Chinese medicine(TCM) shows unique potential in targeting this mechanism. Evidence from human and animal models of heart failure indicates that TCM can restore mitochondrial function by regulating mitochondrial Ca2+ homeostasis, oxidative stress, energy metabolism, mitochondrial dynamics, and mitophagy. TCM-based treatment of CHF offers notable clinical advantages, including improved therapeutic efficacy, enhanced cardiac function, and reduced incidence of major cardiovascular events. Experimental studies demonstrate that TCM decoctions and monomers modulate signaling pathways such as PPAR–RXRα, NF-κB, and PI3K/AKT to alleviate oxidative stress. TCM also increases AMPK activity via phosphorylation of PGC-1α, indirectly promoting mitochondrial biogenesis;attenuates calcium influx and enhances Ca2+ reuptake, thereby ameliorating myocardial mitochondrial dysfunction in CHF;and improves CHF by rebalancing mitochondrial dynamics and autophagy. 展开更多
关键词 Mitochondrial dysfunction Traditional Chinese medicine Chronic heart failure
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Synergistic effects on damage behavior and failure mechanisms of pre-tensioned hybrid laminates subjected to ballistic impacts 认领 引用
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作者 Jian Deng Xuan Gao +5 位作者 Zhenxing Wang Xin Xiong Zhibo Wu Rui Zhang Chuwei Zhou Xinwei Wang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第5期231-242,共12页
Understanding the synergistic effects of preload and impact on damage behavior is critical for composite structures under service conditions,yet it remains inadequate characterization.This study systematically investi... Understanding the synergistic effects of preload and impact on damage behavior is critical for composite structures under service conditions,yet it remains inadequate characterization.This study systematically investigates mechanical responses and failure mechanisms of pre-tensioned hybrid carbon/glass fabric laminates subjected to ballistic impacts with varying velocities and angles.A preload-impact coupled testing platform is developed to perform ballistic impact tests.A rate-dependent numerical model is also proposed to capture detailed damage evolution along with comparative analysis of experimental data.Results show that fiber shearing and interlaminar delamination dominate the failure of laminates.Pretension fundamentally reconfigures damage mechanisms where thresholds exist.Pretension below 10%of the ultimate tensile strength(UTS)enhance energy absorption via stable damage propagation,whereas one exceeding 30%UTS triggers unstable failure.Compared to normal impacts,oblique impacts induce substantially greater delamination,generating distinctive asymmetric damage morphologies through amplified interlaminar shear.Increasing impact velocity reduces delamination,shifting the dominant energy dissipation mechanism from interlaminar fracture to fiber failure.Variations of in-plane impact angles,on the other hand,show infinitesimal influence on failure characteristics.Conclusively,these findings can guide further investigation into specific design guidelines under preload to enhance structural survivability. 展开更多
关键词 Composites Preloads Ballistic impact Failure mechanisms Energy dissipation
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Deformation and progressive failure behavior of silty sand stabilized with waterborne polyurethane:A stress-strain-strength perspective 认领 引用
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作者 BAI Yuxia SONG Zezhuo +4 位作者 CHE Wenyue HE Chengzong BU Fan ZHANG Chenyang DENG Yongfeng 《Journal of Mountain Science》 SCIE CSCD 2026年第6期2874-2890,共17页
Polymers present a promising avenue for soil stabilization,yet the full deformation process and progressive failure characteristics of polymer-treated soils remain insufficiently understood.This study investigates the... Polymers present a promising avenue for soil stabilization,yet the full deformation process and progressive failure characteristics of polymer-treated soils remain insufficiently understood.This study investigates the strength and deformation mechanisms of silty sand stabilized with a widely used waterborne polyurethane(WPU)through unconfined compression tests.Key aspects evaluated include axial stress–strain response,strength parameters,energy absorption capacity(E10 and E20),failure behavior,and post-failure integrity.The effects of curing time and WPU content were systematically examined,supported by microstructural analyses.Results indicate that WPU forms a cohesive three-dimensional polymer network within the soil matrix,fundamentally enhancing strength and transforming the failure mode to progressive ductile bulging.This polymer architecture enables a high unconfined compressive strength(UCS)of up to 812.39 kPa,substantial deformability with failure strains(εf)reaching 12.35%,and notable energy absorption(E₂₀ up to 137.62 kPa).Both strength and toughness increase linearly with curing time and WPU content.An optimal WPU dosage of approximately 3%combined with curing beyond 24 hours is identified to maximize the strength-ductility synergy.Microstructurally,the failure process is delineated into six consecutive stages,governed by the evolution of polymer bridging and interfacial bonding.These findings advance the understanding of the overall deformation-failure behavior of polymer-treated soil and provide deeper insights for the tailored design of polymer-based soil stabilization. 展开更多
关键词 Waterborne polyurethane Silty sand Strength Deformation Progressive failure Soil stabilization
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Precursor characterization of granite biaxial loading failure using the velocity critical slowing down theory 认领 引用
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作者 PEI Zhong-wei DONG Long-jun +1 位作者 ZHANG Yi-han SUN Dao-yuan 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第2期682-702,共21页
Rock failure is accompanied by abnormal stress accumulation and sudden release.However,the invisible internal structure and complex stress environment make it challenging to effectively capture temporal precursors and... Rock failure is accompanied by abnormal stress accumulation and sudden release.However,the invisible internal structure and complex stress environment make it challenging to effectively capture temporal precursors and spatial distribution of stress mutation in the failure process.This paper integrates acoustic emission(AE),traveltime tomography,and critical slowing down theory as a method for investigating granite failure under biaxial compression.The proposed method is applied to monitor the spatial-temporal evolution of stress and identify precursors to stress mutations during rock failure.It not only can investigate expansion trend of micro-cracks and reveal stress evolution patterns through velocity,but also can characterize temporal precursors and spatial distribution of stress mutation.Experiment results show:(1)Traveltime tomography reveals stress-velocity correlations that velocity increases(crack closure/elastic stages)reflect micro-crack compaction and stress concentration,while velocity decreases(stable/unstable stages)indicate fracture propagation;(2)Intermediate principal stress critically modulates these patterns that higher intermediate principal stress amplifies early-stage velocity heterogeneity(local stress concentration)but induces premature micro-fracturing in elastic stages(local velocity drops),resulting in diminished overall velocity changes;(3)Autocorrelation coefficient and spatial variance effectively characterize stress mutation thresholds in time-and space domain respectively.The autocorrelation coefficient detects critical slowing phenomena prior to instability,while spatial variance pinpoints stress anomaly localization.These indexes provide earlier warnings than conventional AE rate thresholds,validated by spatial-temporal alignment with macroscopic fractures.The proposed method enhances real-time monitoring of stress redistribution,offering technical support for early warning and risk mitigation in deep mining engineering. 展开更多
关键词 rock failure traveltime tomography velocity field acoustic emission
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Spatiotemporal water distribution governs anisotropic mechanical weakening and localized tensile failure in sandstone 认领 引用
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作者 Shun Ding Shibin Tang +3 位作者 Hailiang Jia Zhongrui Zhao Heping Xiao Peizhao Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第6期4179-4196,共18页
The mechanical behavior of sandstone is particularly sensitive to changes in water distribution,as water can easily permeate the pore structure.This study investigates the weakening effects and failure modes in sandst... The mechanical behavior of sandstone is particularly sensitive to changes in water distribution,as water can easily permeate the pore structure.This study investigates the weakening effects and failure modes in sandstone using both experiments and numerical simulations under uniform and imbibition conditions.T2spectra were measured to examine the spatiotemporal alterations in pore water types.The uniaxial compressive strength and elastic modulus(Young's modulus)were tested,while stress fields were derived from numerical simulations to analyze the damage mechanism and tensile failure of sandstone.Key findings:(1)The film thickness of bound water progressively increased to transform into capillary and bulk water under uniform conditions,whereas all types of pore water increased concurrently during imbibition.(2)The increase in saturation degree induced a three-stage variation in physical and mechanical properties.At the same saturation degree,the bearing capacity of sandstone under imbibition conditions was higher than that under uniform conditions.(3)The differences in pore water types,elastic modulus,stress thresholds,and acoustic emission(AE)counts were remarkable at the medium saturation stage(20%–60%).(4)AE localization and numerical simulations corroborated that the sudden drop of tensile stress at the wet-dry interface facilitated localized damage accumulation under imbibition conditions.Through analysis of microscopic damage and the spring model inferred,it was inferred that,under uniform conditions,the weakening effects impacted all mineral particles.However,under imbibition conditions,the anisotropic weakening effect(directional damage due to saturation gradient)was only restricted to the wet zone,where short-term damage at the wet-dry interface led to localized tensile failure. 展开更多
关键词 Weakening Different saturation degrees Failure mode Numerical simulation Damage mechanism
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Moxibustion alleviates autophagy and inhibits ferroptosis to improve cardiac function in rats with post-myocardial infarction heart failure 认领 引用
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作者 GAO Bing LIU Pan +7 位作者 LI Lan GONG Tiantian ZHU Ling LI Lingji XIA Ran MA Qiang HU Jing WANG Jing 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第2期339-349,共11页
OBJECTIVE:To explore the mechanism by which moxibustion alleviates autophagy and inhibits ferroptosis,thereby improving myocardial fibrosis in rats with postmyocardial infarction heart failure(post-MI HF).METHODS:We u... OBJECTIVE:To explore the mechanism by which moxibustion alleviates autophagy and inhibits ferroptosis,thereby improving myocardial fibrosis in rats with postmyocardial infarction heart failure(post-MI HF).METHODS:We used a rat model of post-MI HF rats.Interventions included moxibustion and intraperitoneal injection of rapamycin(RAPA)along with assessing echocardiography,cardiac pathology,myocardial mitochondrial morphology,co-immunofluorescence,transmission electron microscope,Western blotting,and reverse transcriptase-quantitative polymerase chain reaction.RESULTS:Moxibustion improves the left ventricular ejection fraction and fractional shortening,myocardial cell morphology,and myocardial fibrosis levels induced by post-MI HF.In addition,it reduces the immunofluorescence co-localization intensity of nuclear receptor coactivator 4(NCOA4)and microtubuleassociated protein 1A/1B light chain 3 and decreases the level of intracellular free iron.It suppresses autophagy and ferroptosis-related indicators,downregulates NCOA4 expression,upregulates glutathione peroxidase 4 expression,and decreases lipid peroxidation levels.The activation of autophagy increases NCOA4 expression and promotes ferroptosis.Furthermore,moxibustion counteracts the effects of RAPA.CONCLUSIONS:Moxibustion can alleviate myocardial fibrosis and exert cardioprotective effects by regulating autophagy and inhibiting ferroptosis.Our findings indicate that targeting autophagy-induced ferroptosis may serve as a novel therapeutic approach for the treatment of postMI HF. 展开更多
关键词 moxibustion nuclear receptor coactivator 4 ferroptosis autophagy heart failure myocardial fibrosis
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An index for evaluating rock failure using energy release and rock brittleness 认领 引用
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作者 Jian Liu Quan Jiang +4 位作者 Tianbing Xiang Yong Xia Dongqi Hou Guangliang Feng Dingping Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第7期5259-5272,共14页
Brittle failures such as rockbursts,stress-induced collapses,and spalling pose major risks in deep hard rock engineering,leading to safety incidents,project delays,and increased costs.While conventional brittleness in... Brittle failures such as rockbursts,stress-induced collapses,and spalling pose major risks in deep hard rock engineering,leading to safety incidents,project delays,and increased costs.While conventional brittleness indices are widely used to assess brittle failure susceptibility,they provide only qualitative assessments and cannot quantify the severity or extent of failure.To address these limitations,we conducted compressive tests on multiple rock types and developed a new brittleness index that captures post-peak ductile to brittle transition characteristics.Based on this index,the brittleness-based relative energy release(BRER)parameter was proposed,which integrates rock brittleness and confiningpressure effects into post-peak energy release calculations.Field validation using acoustic testing and microseismic monitoring demonstrates that BRER reliably predicts both the risk and extent of surrounding rock failure,providing a comprehensive and practical tool for assessing and mitigating brittle failure in deep hard rock environments. 展开更多
关键词 Brittle failure Rockburst Energy index Microseismic monitoring Ductile-brittle transition
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